Academic literature on the topic 'Amphipathic'

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Journal articles on the topic "Amphipathic"

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Hilgemann, Donald W., and Michael Fine. "Mechanistic analysis of massive endocytosis in relation to functionally defined surface membrane domains." Journal of General Physiology 137, no. 2 (2011): 155–72. http://dx.doi.org/10.1085/jgp.201010470.

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A large fraction of endocytosis in eukaryotic cells occurs without adaptors or dynamins. Here, we present evidence for the involvement of lipid domains in massive endocytosis (MEND) activated by both large Ca transients and amphipathic compounds in baby hamster kidney and HEK293 cells. First, we demonstrate functional coupling of the two MEND types. Ca transients can strongly facilitate detergent-activated MEND. Conversely, an amphipath with dual alkyl chains, ditridecylphthalate, is without effect in the absence of Ca transients but induces MEND to occur within seconds during Ca transients. C
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Ivanov, Andrei I., Alexandre A. Steiner, Shreya Patel, Alla Y. Rudaya та Andrej A. Romanovsky. "Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of α1-acid glycoprotein". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, № 4 (2005): R872—R878. http://dx.doi.org/10.1152/ajpregu.00514.2004.

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In view of the potential involvement of peripherally synthesized, circulating amphipathic mediators [such as platelet-activating factor (PAF) and prostaglandin E2] in the systemic inflammatory response to lipopolysaccharide (LPS), we hypothesized that transport of amphipaths by albumin is essential for conveying peripheral inflammatory signals to the brain. Our first specific aim was to test this hypothesis by studying LPS-induced fever and hypothermia in Nagase analbuminemic rats (NAR). NAR from two different colonies and normalbuminemic Sprague-Dawley rats were preimplanted with jugular cath
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Jin, Yi, Janet Hammer, Michelle Pate та ін. "Antimicrobial Activities and Structures of Two Linear Cationic Peptide Families with Various Amphipathic β-Sheet and α-Helical Potentials". Antimicrobial Agents and Chemotherapy 49, № 12 (2005): 4957–64. http://dx.doi.org/10.1128/aac.49.12.4957-4964.2005.

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ABSTRACT Many naturally occurring antimicrobial peptides comprise cationic linear sequences with the potential to adopt an amphipathic α-helical conformation. We designed a linear 18-residue peptide that adopted an amphipathic β-sheet structure when it was bound to lipids. In comparison to a 21-residue amphipathic α-helical peptide of equal charge and hydrophobicity, this peptide possessed more similar antimicrobial activity and greater selectivity in binding to and inducing leakage in vesicles composed of bacterial membrane lipids than vesicles composed of mammalian membrane lipids (J. Blazyk
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Elliott, W. L., C. J. Stille, L. J. Thomas, and R. E. Humphreys. "An hypothesis on the binding of an amphipathic, alpha helical sequence in Ii to the desetope of class II antigens." Journal of Immunology 138, no. 9 (1987): 2949–52. http://dx.doi.org/10.4049/jimmunol.138.9.2949.

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Abstract When we investigated the hypothesis that amphipathic alpha helical peptides digested from foreign antigen bind to class II major histocompatability complex (MHC) molecules' binding site (desetope) for foreign antigen to be presented to T cell receptors, we found such an extended amphipathic helix in Ii. This amphipathic helix was hypothesized to bind Ii to class II MHC antigens until release in endosomes containing digested foreign antigen. Then these amphipathic Ii polypeptides might polymerize so as not to compete with foreign antigen for binding to class II MHC molecules. Various s
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Varkey, Jobin, Jiantao Zhang, Junghyun Kim, et al. "An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles." Viruses 12, no. 12 (2020): 1466. http://dx.doi.org/10.3390/v12121466.

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Positive-strand RNA viruses universally remodel host intracellular membranes to form membrane-bound viral replication complexes, where viral offspring RNAs are synthesized. In the majority of cases, viral replication proteins are targeted to and play critical roles in the modulation of the designated organelle membranes. Many viral replication proteins do not have transmembrane domains, but contain single or multiple amphipathic alpha-helices. It has been conventionally recognized that these helices serve as an anchor for viral replication protein to be associated with membranes. We report her
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Gulsevin, Alican, and Jens Meiler. "Prediction of amphipathic helix—membrane interactions with Rosetta." PLOS Computational Biology 17, no. 3 (2021): e1008818. http://dx.doi.org/10.1371/journal.pcbi.1008818.

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Amphipathic helices have hydrophobic and hydrophilic/charged residues situated on opposite faces of the helix. They can anchor peripheral membrane proteins to the membrane, be attached to integral membrane proteins, or exist as independent peptides. Despite the widespread presence of membrane-interacting amphipathic helices, there is no computational tool within Rosetta to model their interactions with membranes. In order to address this need, we developed the AmphiScan protocol with PyRosetta, which runs a grid search to find the most favorable position of an amphipathic helix with respect to
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Kokeguchi, Susumu, Hiroyuki Ohta, Kazuhiro Fukui, Keijiro Kato, and Masachika Tsujimoto. "Amphipathic antigen fromEubacterium nodatum." FEMS Microbiology Letters 41, no. 1 (1987): 13–17. http://dx.doi.org/10.1111/j.1574-6968.1987.tb02133.x.

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McLean, L. R., J. L. Krstenansky, R. L. Jackson, K. A. Hagaman, K. A. Olsen, and J. E. Lewis. "Mixtures of synthetic peptides and dipalmitoylphosphatidylcholine as lung surfactants." American Journal of Physiology-Lung Cellular and Molecular Physiology 262, no. 3 (1992): L292—L300. http://dx.doi.org/10.1152/ajplung.1992.262.3.l292.

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Synthetic peptides that differ in their lipid-peptide interactions were combined with dipalmitoylphosphatidylcholine (DPPC) and tested in an adult rat lavaged lung model in vitro for efficacy as totally synthetic lung surfactants. The putative amphipathic alpha-helical region of the major lung surfactant apoprotein (SP-A81-102), an analogue with increased amphipathic alpha-helical potential ([Lys88,97,Glu99,Trp102]-SP-A81-102]), and the hydrophobic peptide gramicidin D were all ineffective. Three water-soluble lipid-binding peptides that contain amphipathic alpha-helical regions were also test
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Yu, Lianyuan, Yan Hu, Jinhong Duan, and Xian-Da Yang. "A Novel Approach of Targeted Immunotherapy against Adenocarcinoma Cells with Nanoparticles Modified by CD16 and MUC1 Aptamers." Journal of Nanomaterials 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/316968.

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Mucin 1 (MUC1) is a potentially important target of cancer therapy, being a glycoprotein that is overexpressed on cell surface of many types of adenocarcinomas, including breast, ovarian, colon, lung, and prostatic cancers. Several MUC1-targeted drug delivery systems have been developed and reported, but mobilizing natural killer cells (NK) to fight against MUC1-positive tumor has not been attempted. In this study, we introduced a novel amphipathic nanoparticle (NP) for enhancing the NK cytotoxicity to MUC1-positive cancer cells. The amphipathic NP had CD16 and MUC1 aptamers on its surface and
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Yang, Feng, Tiantian Li, Ziqing Peng, Yang Liu, and Yusong Guo. "The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations." Journal of Biological Chemistry 295, no. 49 (2020): 16643–54. http://dx.doi.org/10.1074/jbc.ra120.014999.

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The subcellular localization of Arf family proteins is generally thought to be determined by their corresponding guanine nucleotide exchange factors. By promoting GTP binding, guanine nucleotide exchange factors induce conformational changes of Arf proteins exposing their N-terminal amphipathic helices, which then insert into the membranes to stabilize the membrane association process. Here, we found that the N-terminal amphipathic motifs of the Golgi-localized Arf family protein, Arfrp1, and the endosome- and plasma membrane–localized Arf family protein, Arl14, play critical roles in spatial
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Dissertations / Theses on the topic "Amphipathic"

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Charbonneau, Sophie. "The hemostatic effects of amphipathic helices." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86625.

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The amphipathic helix structural motif is often found in biologically active peptides and proteins. On one side of the helix, polar residues are aligned, whereas the other side is composed of hydrophobic residues. Ideal Amphipathic Peptides (IAP) composed of only lysine and leucine residues, in a 1:2 ratio (KLLKLLL sequences) were developed in the 1990's as bacteriocidal agents. These peptides are helical, with a positively charged hydrophilic side composed of lysine residues, and a hydrophobic face composed of the leucine residues.<br>We demonstrate that a 22-mer IAP possesses procoagulant pr
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Giménez, Andrés Manuel. "Interaction of perilipin amphipathic helices with lipid droplets The Many Faces of Amphipathic Helices A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL006.

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Les gouttelettes lipidiques (LDs) sont des réservoirs d'énergie et des compartiments membranaires. Elles sont composées d'un noyau des lipides neutres et d'une monocouche de phospholipides associées à des protéines. Les hélices amphipathiques (AHs), sont des structures protéiques secondaires qui interagissent avec les membranes des organelles. La manière dont les AHs interagissent avec la surface des LDs reste largement méconnue. Les périlipines sont une famille de protéines abondantes dans les LDs. Elles utilisent les AHs pour cibler les LDs. Certains de leurs membres ont des fonctions bien d
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Ismail, F. M. D. "Inhibition of lipid autoxidation in amphipathic systems." Thesis, University of Salford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234723.

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Shyam, Radhe. "Cationic amphipathic peptoid oligomers as antimicrobial peptide mimics." Thesis, Université Clermont Auvergne‎ (2017-2020), 2018. http://www.theses.fr/2018CLFAC048/document.

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Les organismes vivants produisent des peptides antimicrobiens (PAMs) pour se protéger contre les microbes. La résistance croissante aux antibiotiques nécessite le développement de nouvelles stratégies thérapeutiques et les PAMs sont des candidats prometteurs pour résoudre ce problème. Ils possèdent une activité à large spectre et leur principal mécanisme d'action par perméation de la membrane engendre peu de phénomènes de résistance. Néanmoins, leur faible biodisponibilité empêche leur utilisation. Certaines limitations peuvent être surmontées en développant des mîmes de PAMs qui conservent le
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Lynch, Andrew Lee. "Amphipathic polymers for cell membrane permeabilisation and biopreservation." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609895.

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Cherry, Melissa A. "Sequence dependence of the activity of amphipathic peptides." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-2/rp/cherrym/melissacherry.pdf.

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Wessolowski, Axel. "Amphipathische Hexapeptide - Interaktion mit Membranen Amphipathic hexapeptides - interaction with membranes /." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/150/index.html.

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Tena, Solsona Marta. "Hydrogels based on short amphipathic peptides: self-assembly studies and apllications." Doctoral thesis, Universitat Jaume I, 2015. http://hdl.handle.net/10803/669007.

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I. Tema y objetivos de la tesis Debido a la estrecha relación entre el auto-ensamblaje de péptidos y proteínas con las enfermedades de tipo amiloide,(1) entender los principios que gobiernan este fenómeno resulta de gran interés en la actualidad. El uso de pequeños péptidos como modelos o inhibidores del proceso de fibrilación es considerado una de las mejores aproximaciones debido a su facilidad de síntesis, versatilidad y biocompatibilidad.(2) Se conoce además que la organización jerárquica de estas fibrillas peptídicas da lugar a menudo a redes auto-ensambladas que retienen el disolvent
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Ahmed, S. "Pulse radiolysis and fluorescence studies of #alpha#-tocopherol in amphipathic systems." Thesis, University of Salford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376851.

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Liang, Wanling, and 梁婉玲. "Formulation of nucleic acid with pH-responsive amphipathic peptides for pulmonary delivery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207996.

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Books on the topic "Amphipathic"

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1937-, Epand Richard M., ed. The Amphipathic helix. CRC Press, 1993.

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Epand, Richard M. The Amphipathic Helix. CRC Press, 2024. https://doi.org/10.1201/9781003574378.

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Ismail, Fyaz Mahmood Daud. Inhibition of lipid autoxidation in amphipathic systems. University of Salford, 1989.

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Ahmed, Shabir. Pulse radiolysis and fluorescence studies of a-tocopherol in amphipathic systems. University of Salford, 1986.

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Wiklund, Olov, and Jan Borén. Pathogenesis of atherosclerosis: lipid metabolism. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0011.

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Lipids are carried in plasma as microparticles, lipoproteins, composed of a core of hydrophobic lipids and a surface of amphipathic lipids. In addition, the particles carry proteins (i.e. apolipoproteins). The proteins have key functions in the metabolism as receptor ligands, enzymes or activators. Lipoproteins are classified based on density into: chylomicrons, VLDL, IDL, LDL, and HDL. Retention of apoB-containing lipoproteins (LDL, IDL, and VLDL) in the arterial intima is the initiating event in the development of atherosclerosis. Retention is mediated by binding of apoB to structural proteo
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Book chapters on the topic "Amphipathic"

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Scherrmann, Jean-Michel, Kim Wolff, Christine A. Franco, et al. "Amphipathic." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4050.

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Gooch, Jan W. "Amphipathic." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13111.

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Opella, S. J., J. Gesell, and B. Bechinger. "NMR Spectroscopy of Amphipathic Helical Peptides in Membrane Environments." In The Amphipathic Helix. CRC Press, 2024. https://doi.org/10.1201/9781003574378-8.

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Tomich, John M. "Amphipathic Helices in Channel-Forming Structures." In The Amphipathic Helix. CRC Press, 2024. https://doi.org/10.1201/9781003574378-13.

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Yang, Daniel S. C. "Protein-Ice Interactions: Antifreeze Proteins." In The Amphipathic Helix. CRC Press, 2024. https://doi.org/10.1201/9781003574378-21.

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Waring, Alan J., Larry M. Gordon, H. William Taeusch, and Roberta Bruni. "Amphipathic Helical Segments in Lung Surfactant Proteins." In The Amphipathic Helix. CRC Press, 2024. https://doi.org/10.1201/9781003574378-11.

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Taylor, John W. "Amphiphilic Helices in Neuropeptides." In The Amphipathic Helix. CRC Press, 2024. https://doi.org/10.1201/9781003574378-16.

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Anantharamaiah, G. M., Martin K. Jones, and Jere P. Segrest. "An Atlas of the Amphipathic Helical Domains of Human Exchangeable Plasma Apolipoproteins." In The Amphipathic Helix. CRC Press, 2024. https://doi.org/10.1201/9781003574378-10.

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Mousli, Mousafak, and Yves Landry. "Activation of G Proteins by Membrane Receptors and Peptides: Putative Role for Amphipathic Helices." In The Amphipathic Helix. CRC Press, 2024. https://doi.org/10.1201/9781003574378-17.

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Goormaghtigh, Erick, Véronique Cabiaux, and Jean-Marie Ruysschaert. "Polarized Attenuated Total Reflection Infrared Spectroscopy as a Tool to Investigate the Structure and Orientation of Amphipathic Peptides in a Lipid Bilayer." In The Amphipathic Helix. CRC Press, 2024. https://doi.org/10.1201/9781003574378-7.

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Conference papers on the topic "Amphipathic"

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Kramer, Jeffrey F., Arpita Srivastava, and Steven F. Strba. "Comparative Performance of Biocides versus Corrosion Causing Biofilms." In CORROSION 2010. NACE International, 2010. https://doi.org/10.5006/c2010-10258.

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Abstract Biofilms can cause severe problems in oilfield water systems. The biocidal efficacy of several common oilfield biocides was evaluated versus a defined microbial biofilm. In addition to their biocidal performance, the biofilm removal properties of the biocides were determined using epifluorescent microscopy. The comparative biocidal testing showed that the amphipathic phosphonium quat – tributyl tetradecyl phosphonium chloride (TTPC) was more effective versus biofilm microorganisms than the non-amphipathic THPS. TTPC also showed better biofilm removal properties than THPS and glutarald
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Lemos, Reinier, Luis Almagro, Blanca Tolón Murgía, and Margarita Suárez. "Amphipathic malonates as potential antiviral agents." In 7th International Electronic Conference on Medicinal Chemistry. MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11392.

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Schmitt, Adeline M., and Helma Wennemers. "Amphipathic Proline-Rich Cell Penetrating Peptides for Mitochondria Targeting." In 37th European Peptide Symposium. The European Peptide Society, 2024. http://dx.doi.org/10.17952/37eps.2024.p1231.

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Nilsson, Bradley L., Danielle M. Raymond та Jade J. Welch. "Rippled β-Sheet Fibrils from Coassembled Enantiomeric Amphipathic Peptides as Potential Microbicide Biomaterials". У The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.033.

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Lee, Yeon Sun, Sara M. Hall, Cyf Ramos-Colon, et al. "Amphipathic Non-opioid Dynorphin A Analogs to Inhibit Neuroexcitatory Effects at Central Bradykinin Receptors." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.080.

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Hirano, Motoharu, Hidetomo Yokoo, Makoto Oba, Takashi Misawa, and Yosuke Demizu. "Development of novel amphipathic stapled peptides as DDS carriers for intracellular delivery of nucleic acids." In 37th European Peptide Symposium. The European Peptide Society, 2024. http://dx.doi.org/10.17952/37eps.2024.p1225.

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Eike, Liv-Marie, Brynjar Mauseth, Ketil Camilio, Oystein Rekdal, and Baldur Sveinbjornsson. "Abstract 4274: Anticancer mechanisms of a small amphipathic molecule, LTX-401, against B16 melanoma cancer cells." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4274.

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Rajbhandary, Annada, and Bradley L. Nilsson. "Investigating the Effects of Aromatic Amino Acids on Amphipathic Peptide Self-Assembly and Emergent Hydrogel Viscoelasticity." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.228.

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Creasy, M. Austin, and Donald J. Leo. "Non-Invasive Measurement Techniques for Measuring Bilayers in Droplet-Interface-Bilayers." In ASME 2009 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2009. http://dx.doi.org/10.1115/smasis2009-1321.

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Phospholipids and membrane proteins are two of the fundamental building blocks of cell membranes in living organisms. These molecules are amphipathic and synthetic membranes made of phospholipids, called bilayer lipid membranes (BLMs), are used to understand the characteristics of a cell membrane. Studies of these BLMs have been performed on both solid support and liquid support systems. A droplet interface bilayer (DIB) is a liquid support system where a monolayer is formed around a water droplet placed in oil and a bilayer is formed when two of these droplets are placed in contact. For imped
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Jiang, Ziqing, Adriana I. Vasil, Lajos Gera, Michael L. Vasil та Robert S. Hodges. "Specificity determinants dramatically reduce hemolytic activity in amphipathic α-helical antimicrobial peptides: antimicrobial activity against Gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa". У Proceedings of the International Conference on Antimicrobial Research (ICAR2010). WORLD SCIENTIFIC, 2011. http://dx.doi.org/10.1142/9789814354868_0074.

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Reports on the topic "Amphipathic"

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Naim, Michael, Andrew Spielman, Shlomo Nir, and Ann Noble. Bitter Taste Transduction: Cellular Pathways, Inhibition and Implications for Human Acceptance of Agricultural Food Products. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7695839.bard.

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Historically, the aversive response of humans and other mammals to bitter-taste substances has been useful for survival, since many toxic constituents taste bitter. Today, the range of foods available is more diverse. Many bitter foods are not only safe for consumption but contain bitter constituents that provide nutritional benefits. Despite this, these foods are often eliminated from our current diets because of their unacceptable bitterness. Extensive technology has been developed to remove or mask bitterness in foods, but a lack of understanding of the mechanisms of bitterness perception a
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Wang, X. F., and M. Schuldiner. Systems biology approaches to dissect virus-host interactions to develop crops with broad-spectrum virus resistance. United States-Israel Binational Agricultural Research and Development Fund, 2020. http://dx.doi.org/10.32747/2020.8134163.bard.

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More than 60% of plant viruses are positive-strand RNA viruses that cause billion-dollar losses annually and pose a major threat to stable agricultural production, including cucumber mosaic virus (CMV) that infects numerous vegetables and ornamental trees. A highly conserved feature among these viruses is that they form viral replication complexes (VRCs) to multiply their genomes by hijacking host proteins and remodeling host intracellular membranes. As a conserved and indispensable process, VRC assembly also represents an excellent target for the development of antiviral strategies that can b
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