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Dissertations / Theses on the topic 'Amphipathic'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Charbonneau, Sophie. "The hemostatic effects of amphipathic helices." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86625.

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The amphipathic helix structural motif is often found in biologically active peptides and proteins. On one side of the helix, polar residues are aligned, whereas the other side is composed of hydrophobic residues. Ideal Amphipathic Peptides (IAP) composed of only lysine and leucine residues, in a 1:2 ratio (KLLKLLL sequences) were developed in the 1990's as bacteriocidal agents. These peptides are helical, with a positively charged hydrophilic side composed of lysine residues, and a hydrophobic face composed of the leucine residues.<br>We demonstrate that a 22-mer IAP possesses procoagulant pr
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2

Giménez, Andrés Manuel. "Interaction of perilipin amphipathic helices with lipid droplets The Many Faces of Amphipathic Helices A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL006.

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Les gouttelettes lipidiques (LDs) sont des réservoirs d'énergie et des compartiments membranaires. Elles sont composées d'un noyau des lipides neutres et d'une monocouche de phospholipides associées à des protéines. Les hélices amphipathiques (AHs), sont des structures protéiques secondaires qui interagissent avec les membranes des organelles. La manière dont les AHs interagissent avec la surface des LDs reste largement méconnue. Les périlipines sont une famille de protéines abondantes dans les LDs. Elles utilisent les AHs pour cibler les LDs. Certains de leurs membres ont des fonctions bien d
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3

Ismail, F. M. D. "Inhibition of lipid autoxidation in amphipathic systems." Thesis, University of Salford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234723.

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4

Shyam, Radhe. "Cationic amphipathic peptoid oligomers as antimicrobial peptide mimics." Thesis, Université Clermont Auvergne‎ (2017-2020), 2018. http://www.theses.fr/2018CLFAC048/document.

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Les organismes vivants produisent des peptides antimicrobiens (PAMs) pour se protéger contre les microbes. La résistance croissante aux antibiotiques nécessite le développement de nouvelles stratégies thérapeutiques et les PAMs sont des candidats prometteurs pour résoudre ce problème. Ils possèdent une activité à large spectre et leur principal mécanisme d'action par perméation de la membrane engendre peu de phénomènes de résistance. Néanmoins, leur faible biodisponibilité empêche leur utilisation. Certaines limitations peuvent être surmontées en développant des mîmes de PAMs qui conservent le
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5

Lynch, Andrew Lee. "Amphipathic polymers for cell membrane permeabilisation and biopreservation." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609895.

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6

Cherry, Melissa A. "Sequence dependence of the activity of amphipathic peptides." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-2/rp/cherrym/melissacherry.pdf.

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7

Wessolowski, Axel. "Amphipathische Hexapeptide - Interaktion mit Membranen Amphipathic hexapeptides - interaction with membranes /." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/150/index.html.

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8

Tena, Solsona Marta. "Hydrogels based on short amphipathic peptides: self-assembly studies and apllications." Doctoral thesis, Universitat Jaume I, 2015. http://hdl.handle.net/10803/669007.

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I. Tema y objetivos de la tesis Debido a la estrecha relación entre el auto-ensamblaje de péptidos y proteínas con las enfermedades de tipo amiloide,(1) entender los principios que gobiernan este fenómeno resulta de gran interés en la actualidad. El uso de pequeños péptidos como modelos o inhibidores del proceso de fibrilación es considerado una de las mejores aproximaciones debido a su facilidad de síntesis, versatilidad y biocompatibilidad.(2) Se conoce además que la organización jerárquica de estas fibrillas peptídicas da lugar a menudo a redes auto-ensambladas que retienen el disolvent
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9

Ahmed, S. "Pulse radiolysis and fluorescence studies of #alpha#-tocopherol in amphipathic systems." Thesis, University of Salford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376851.

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10

Liang, Wanling, and 梁婉玲. "Formulation of nucleic acid with pH-responsive amphipathic peptides for pulmonary delivery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207996.

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11

McCaffrey, J. "Gene delivery via polymeric microneedles : the use of a novel amphipathic peptide." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.679228.

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The focus of this thesis was to develop a two-tier delivery system suitable for DNA delivery in vivo. Firstly, 4 peptides were investigated to determine their ability to overcome the intracellular and extracellular barriers which inhibit the expression of 'naked' DNA when administered in vivo. The RALA peptide was identified as the most efficient DNA delivery vehicle, eliciting greater gene expression in vitro and in vivo following intradermal injection compared to the delivery of 'naked' DNA. The RALA delivery vehicle was also significantly less toxic than the current commercially available g
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12

Kaner, Rebecca A. "Amphipathic α-helix mimetics through asymmetric self-assembly on a metal scaffold". Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/66673/.

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Chapter 1 | Reviews innate host-defence α-helices and their mimetics as potential anticancer chemotherapeutics. Introduces biologically relevant bimetallic triple metallohelices as potential non-peptide mimics, and reviews the known flexicates. Discusses the criteria such compounds would need to satisfy in order to be successful anticancer agents. Chapter 2 | Describes the discovery, synthesis and characterisation of nineteen new class Ib flexicates with varying ligand functionality. These compounds are found to be highly active and selective in cancer, with no observed activity in bacteria. P
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13

Kamo, Tomoari. "Lipid membrane structure modulated by nonlamellar-forming lipids and interaction with amphipathic peptide." 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/137121.

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14

Polozov, Ivan V. "Interactions of class A and class L amphipathic helical peptides with model membranes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0006/NQ30110.pdf.

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15

Martyna, Agnieszka. "Structure and function of the M2 amphipathic helix in influenza virus membrane scission." Thesis, University of Kent, 2016. https://kar.kent.ac.uk/56663/.

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Influenza A is an enveloped, negative sense RNA virus which causes annual epidemics and major pandemics. Assembly and budding of new viral particles is a complex and multistep process, of which many aspects remain unclear despite many years of research. The Influenza virus M2 protein is a homotetrameric transmembrane protein, containing three domains: ecto domain, transmembrane domain and cytoplasmic tail (CT). In the final stage of budding it has been shown that M2 mediates membrane scission through an amphipathic helix (AH), which is formed by the first 17 amino acids of the protein's CT, ho
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16

Tanaka, Masafumi. "Membrane Structure of Lipid Particles and Binding of Amphipathic α-Helices of Plasma Apolipoproteins". 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/147925.

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17

Leswin, Joost Sieger Kaspar. "Particle Formation in RAFT-mediated Emulsion Polymerization." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2176.

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Particle formation in RAFT-mediated emulsion polymerization has been studied using reaction calorimetry. By measuring the heat flow during controlled feed ab-initio emulsion polymerization in the presence of amphipathic RAFT agents, particle formation by self-assembly of these species could be observed. Two different monomer systems, i.e. styrene and n-butyl acrylate, and various degrees of hydrophobicity of the initial macro-RAFT agents have been studied and compared. The different macro-RAFT agents were synthesized by first forming a hydrophilic block of poly(acrylic acid) that would later o
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18

Leswin, Joost Sieger Kaspar. "Particle Formation in RAFT-mediated Emulsion Polymerization." University of Sydney, 2007. http://hdl.handle.net/2123/2176.

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Doctor of Philosophy(PhD)<br>Particle formation in RAFT-mediated emulsion polymerization has been studied using reaction calorimetry. By measuring the heat flow during controlled feed ab-initio emulsion polymerization in the presence of amphipathic RAFT agents, particle formation by self-assembly of these species could be observed. Two different monomer systems, i.e. styrene and n-butyl acrylate, and various degrees of hydrophobicity of the initial macro-RAFT agents have been studied and compared. The different macro-RAFT agents were synthesized by first forming a hydrophilic block of poly(acr
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19

Scott, Brian R. "Structure-function relationships of human apolipoprotein A-I: Role of the amino-terminal amphipathic alpha-helices." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6328.

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To investigate the role(s) of the globular domain (residues 1-43) and the first class A helix (residues 44-65) of apolipoprotein A-I (apoA-I) in the metabolism of high density lipoproteins (HDL), we have taken a combined in vitro and in vivo approach. This work demonstrates that both the globular domain and helix 1 of apoA-I are important for the maturation of HDL. Deletions of these domains were associated with progressive impairments in the ability of apoA-I to activate lecithin:cholesterol acyltransferase (LCAT) and form cholesterol ester rich HDL. While phospholipid binding was significant
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20

TUBB, MATTHEW ROBERT. "Apolipoprotein A-IV Structural Models and Functional Implications." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1218826062.

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21

Pinto, Marta Heidtmann. "Produção de biossurfactantes bacteriano e fúngico por fermentação em estado sólido e submersa utilizando resíduos agroindustriais." reponame:Repositório Institucional da FURG, 2008. http://repositorio.furg.br/handle/1/2737.

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Dissertação(mestrado) - Universidade Federal do Rio Grande, Programa de Pós-Graduação em Engenharia e Ciência de Alimentos, Escola de Química e Alimentos, 2008.<br>Submitted by Caroline Silva (krol_bilhar@hotmail.com) on 2012-09-24T17:43:54Z No. of bitstreams: 1 dissertao marta.pdf: 2219216 bytes, checksum: dabe85cdb78a95658dc970cbd0e37ce1 (MD5)<br>Approved for entry into archive by Bruna Vieira(bruninha_vieira@ibest.com.br) on 2012-11-09T13:16:33Z (GMT) No. of bitstreams: 1 dissertao marta.pdf: 2219216 bytes, checksum: dabe85cdb78a95658dc970cbd0e37ce1 (MD5)<br>Made available in DSpace on 2012
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He, Jing. "Design and Study of Novel Antimicrobial Peptides with Proline Substitution." Ohio University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1257779581.

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23

Gonzalez-Rubio, Garrido Paula. "Nouvelles perspectives pour comprendre la reconnaissance des défauts d'empaquetage lipidique par le senseur de courbure membranaire ALPS (Amphipathic Lipid Packing Sensor)." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2009. http://tel.archives-ouvertes.fr/tel-00813418.

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Des motifs structuraux largement impliqués dans les processus de modulation de la courbure membranaire sont les hélices amphipathiques. Parmi eux, un senseur de la courbure exhibant des propriétés particulières a été identifiée récemment : ALPS (ArfGAP1 Amphipathic lipid packing sensor). Il a été montré que son interaction avec la membrane était indépendante des charges Žlectrostatiques En effet, le modèle actuel suggère que les résidus hydrophobes soient les responsables de l'ancrage d'ALPS ˆ la membrane en reconaissant les défauts d'empaquetage lipidique. Par simulations par dynamique molécu
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Felizatti, Ana Paula. "MEGs de S. mansoni contendo hélices anfipáticas: caracterização da interação com bicamadas lipídicas." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-15092017-075924/.

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A classe de proteínas das MEGs (codificadas por genes de micro-éxon) presente em Schistosoma mansoni, ganhou evidência após a publicação do genoma deste parasita, principalmente por ser majoritariamente secretada, estando em contato direito com moléculas do hospedeiro, e possuir alta taxa de variação, o que poderia ter relação com um possível um mecanismo de evasão do sistema imune. Assim, foram escolhidas proteínas da classe das MEGs, todas com predição de hélice anfipática em sua estrutura, para investigação neste trabalho. Hélices anfipáticas são amplamente descritas na literatura como tend
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25

Brady, Jacob Peter. "The molecular basis for ER tubule formation." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:fb5ce78d-0bc8-46dd-9552-04f1f1ec1d0f.

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Integral membrane proteins of the DP1 and reticulon families are responsible for maintaining the high membrane curvature required for both smooth ER tubules and the edges of ER sheets. Mutations in these proteins lead to motor neurone diseases such as hereditary spastic paraplegia. Reticulon/DP1 proteins contain Reticulon Homology Domains (RHD) that have unusually long (&asymp;30 aa) hydrophobic segments and are proposed to adopt intramembrane helical hairpins that stabilise membrane curvature. I have uncovered the secondary structure and dynamics of the DP1 protein Yop1p and identified a C-te
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26

Gebus, Adrien. "From lipid-mediated molecular interactions to a synergistic antimicrobial activity : a study of PGLa and magainin 2 amphipathic peptides using NMR spectroscopy and in silico molecular dynamics simulations." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF017.

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PGLa et magainin 2 sont deux peptides amphiphiles, avec une activité antimicrobienne synergique. Nous avons étudié la structure et la dynamique de ces peptides, ainsi que leurs interactions avec les membranes. Par spectroscopie RMN en phase solide et liquide nous avons obtenu des informations sur la structure de PGLa dans un environnement hydrophobe.Un modèle 3D de PGLa en micelles a été construit, et différentes populations de PGLa en bicouche lipidique on été identifiées. Des simulations de MD ont permis d'étudier l'interaction de PGLa et magainin 2 entre eux et avec avec la membrane. Nous e
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27

Bacle, Amélie. "Etude in silico des gouttelettes lipidiques et de leur interaction avec des protéines périphériques via des hélices amphipathiques." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC235/document.

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Les gouttelettes lipidiques (GL) sont des organites intracellulaire qui jouent un rôle central dans le métabolisme des lipides. Elles sont également impliquées dans des maladies telles que l'obésité ou le diabète. Les GL ont une structure unique : une monocouche de phospholipides (PL) qui entoure un cœur de lipide neutre composé de triglycérides (TAG) et d'esters de cholestérol (CE). Certaines protéines sont recrutées sur les GL mais également à la surface d'autres organites, alors que d'autres protéines ciblent spécifiquement la surface des GL. Il a été montré que quelques une de ces protéine
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Antunes, Stéphanie. "Agents antimicrobiens innovants de type foldamère pour le contrôle de l'infection par des pathogènes du risque biologique : application à Bacillus anthracis." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0304/document.

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Face à l’émergence de pathogènes multi-résistants aux antibiotiques classiques, et au développement des armes biologiques, la découverte de nouveaux agents antimicrobiens reste un enjeu majeur de santé public. Dans ce contexte, la conception d’oligomères peptidomimétiques, capables de mimer le caractère amphiphile et la structure en hélice des peptides antimicrobiens naturels, effecteurs clés de l’immunité innée, offre d’intéressantes perspectives. Il a été établi que des foldamères à base d’urées amphipathiques, structurés en hélice-2,5, possédaient une forte activité bactéricide contre Bacil
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Pranke, Iwona Maria. "Specificity of membrane targeting by ALPS motifs and α-synuclein". Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112265.

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La communication entre les différentes organelles se fait par l’intermédiaire du trafic vésiculaire, un processus qui nécessite un remodelage continu des membranes. Les vésicules fortement courbées bourgeonnent d'un compartiment donneur et fusionnent avec un compartiment accepteur. Les protéines impliquées dans le bourgeonnement et fusion des vésicules ont été largement étudiées. Récemment, la découverte de détecteurs de courbure membranaire a révélé que le trafic membranaire pourrait être régulé à un niveau supplémentaire, par la détection de la forme de la membrane. Le premier détecteur de c
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Bouvet, Samuel. "Lipides et trafic : rôles de GBF1, facteur d’échange de la petite protéine G Arf1." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112172/document.

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La cellule eucaryote compartimentalise ses tâches au sein d’organelles communiquant les unes avec les autres au moyen de vésicules de transport. Le trafic vésiculaire est contrôlé par des petites protéines G de la superfamille Ras, activées par un changement de nucléotide guanidique catalysé par un facteur d’échange (GEF). En particulier, au niveau du cis-Golgi la petite protéine G Arf1 est activée par GBF1, permettant le transport rétrograde des vésicules COPI vers le réticulum endoplasmique. Récemment, GBF1 a été impliqué dans d’autres fonctions, notamment dans le cycle réplicatif de certain
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31

Svangård, Erika. "Cytotoxic Cyclotides : Structure, Activity, and Mode of Action." Doctoral thesis, Uppsala universitet, Institutionen för läkemedelskemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6028.

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Cyclotides are small cyclic plant proteins, and this thesis addresses their cytotoxic structure-activity properties and their mode of action on human cancer cell lines. Cyclotides were isolated from Viola odorata and Viola tricolor; three novel cyclotide sequences and two known sequences, but of new origin, were identified using mass spectrometry, amino acid analysis, and Edman degradation. The cyclotide structure includes three disulphide bonds in a knotted arrangement, which forces hydrophobic amino acid residues to be exposed on the surface of the molecule; 3-D homology models of cyclotides
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Chesarino, Nicholas M. "Defining the Biochemical Factors Regulating IFITM3-Mediated Antiviral Activity." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1480426112676394.

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Moriceau, Lucille. "Caractérisation de la protéine 140K impliquée dans l’adressage aux chloroplastes des complexes de réplication du virus de la mosaïque jaune du navet (TYMV)." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS255/document.

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Le virus de la mosaïque jaune du navet (TYMV) possède un génome monopartite constitué d’ARN de polarité positive codant pour trois protéines, dont seule la polyprotéine 206K est indispensable à la réplication virale.Elle subit une maturation protéolytique, générant les protéines 140K et 66K, localisées au niveau de l’enveloppe des chloroplastes, siège de la réplication virale.Adressée aux chloroplastes, la protéine 140K y recrute la 66K et se comporte comme une protéine intégrale membranaire.Le domaine d’adressage aux chloroplastes (DAC) de la protéine 140K a été défini grâce à la transfection
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Hajhassan, Houssein. "Synthese et etude de la structure et de proprietes de lipopeptides amphipatiques." Orléans, 1987. http://www.theses.fr/1987ORLE2007.

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Des lipopeptides amphipathes ont ete synthetises : suivant la methode utilisee. On obtient des lipsamino-acides ou des lipopeptides ; etude par diffraction x, proprietes tensio-actives, pouvoir emulsifiant. Par le test d'hemolyse, il a ete montre que certains lipopeptides ont une hemocompatibilite similaire a celles des meilleurs tensio-actifs bicatenaires
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Floch, Aurélie. "Mécanismes d'adressage de Pom33, protéine transmembranaire associée aux pores nucléaires chez la levure Saccharomyces cerevisiae levure Saccharomyces cerevisiae." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112182.

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Chez les eucaryotes, les pores nucléaires (NPCs), ancrés dans l’enveloppe nucléaire (EN), régulent les échanges nucléocytoplasmiques. Ces complexes, très conservés, sont composés d’une trentaine de protéines appelées nucléoporines (Nups) présentes en multiples copies au sein de chaque NPC. Chez la levure S. cerevisiae, seules quatre Nups, dont la protéine Pom33, possèdent des domaines transmembranaires. Une étude réalisée en amont de ce projet a permis de caractériser Pom33 et de montrer que le mutant pom33∆ est viable et ne présente pas de défaut apparent de transport nucléocytoplasmique mais
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Yeomans-Maldonado, Larisa. "Glycopeptide and Phosphopeptide Analogs of DAMGO: A Study on the Role of Amphipathicity to Promote Blood Brain Barrier Penetration." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195248.

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Glycosylation may be a general strategy for the transport of biologically active neuro(glyco)peptides into the brain. With that in mind, a series of modified DAMGO analogues were synthesized and subjected to conformational analysis, and in vitro and in vivo studies related to opioid analgesia. Those studies will help to determine the balance of carbohydrate and peptide, to reach maximum BBB transport; in other words this is a study to test the biousian hypothesis. 1) The μ-agonist DAMGO was altered by incorporating moieties of increasing water solubility into the C-terminus, including carboxam
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Tengel, Tobias. "Studies of protein structure, dynamics and protein-ligand interactions using NMR spectroscopy." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1472.

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Lee, Cheng, and 李正. "Styrene Emulsion Polymerization Stabilized by Amphipathic Graft Copolymers." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/58264630282753476253.

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碩士<br>國立臺灣科技大學<br>化學工程系<br>88<br>Batch styrene emulsion polymerizations stabilized by ACPEG and four amphipathic graft copolymers were carried out, using sodium persulfate as the initiator. The parameters chosen for this study include the concentration and hydrophilicity of amphipathic graft copolymers, the initiation concentration and temperature. The results show that both the final conversion and polymerization rate increase with increasing concentrations of ACPEG and amphipathic graft copolymers. However, the total scrap and the latex particle size (or number of particles) decre
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"Amphipathic polymer assembly and small-molecule interfacial adsorption." Tulane University, 2020.

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Yu-xin, Xiao, and 蕭煜馨. "Preparation of Amphipathic Cesium Tungsten by Nitroxide Transfer Polymerization." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8c9an2.

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碩士<br>國立高雄應用科技大學<br>化學工程與材料工程系博碩士班<br>106<br>Cesium-tungsten oxide(Cs0.33WO3) nanoparticles have good near-infraed absorption capability and are often used in insulation material. Due to Cs0.33WO3 is easily agglomerated, silane-modified Cs0.33WO3 was used to improve above problem. However, silane-modified Cs0.33WO3 can only disperse in polar (water) or non-polar (toluene) solvent, and that limit its applications. In this study, the amphiphilic polymers were prepared by the nitroxide mediated polymerization. First, the macroinitiator of 2-Ethylhexyl acrylate (2-EHA) was polymerized, and the
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Jafari, Mousa. "Design, Characterization and Application of Amphipathic Peptides for siRNA Delivery." Thesis, 2013. http://hdl.handle.net/10012/7279.

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Short interfering RNAs (siRNAs) are 21-23 nucleotide-long double-stranded RNA molecules that can trigger the RNA interference (RNAi). RNAi is a post-transcriptional gene silencing process whereby siRNAs induce the sequence-specific degradation of complementary messenger RNA (mRNA). Despite their promising therapeutic capabilities, siRNA-based strategies suffer from enzymatic degradation and poor cellular uptake. Several carrier-based approaches have been employed to enhance the stability and efficiency of siRNA delivery. Considering their safety, efficiency, and targeting capabilities, peptide
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Lin, Hau-yu, and 林皓譽. "Synthesis of amphipathic polymer by using cellobiose for gene delivery." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/73682410004663218743.

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碩士<br>國立臺灣科技大學<br>化學工程系<br>96<br>In non-viral vector system, avoided safety and immunity viral vector of viral vector which used liposomes and cationic polymer to be a vector of gene. Hydrophilic highly, stable and biocompatible hightly cellobiose and hydrophobic and biocompatible hightly 12-aminododecanoic acid were formed an amphipathic polymer. Amphipathic polymer were used as major DNA carrier. At first, there were three materials for synthesis formed an amphipathic polymer .We used DNA of 0.5 μg/μl to do DNA electrophoresis, and investigated how the ability of the carrier bound DNA. And
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Lien, Yu-Hsien, and 連育賢. "Micelle formation of amphipathic peptides and membrane insertion - CGMD simulations." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/40936751573575023812.

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碩士<br>國立陽明大學<br>生醫光電研究所<br>103<br>Molecules with amphipathic characteristic tend to form micelles and larger assemblies such as the lipid bilayer in aqueous solution. The molecules aim to minimize the contact of the hydrophobic part with water and maximize the contact with the hydrophilic part. Formation of the micelles affects amphipathic drug molecules which are seen as potential candidates for interacting with targets at the site of the lipid membrane. Micelle formation and membrane insertion of biological relevant peptides is investigated in multi micro second coarse grained molecular dyna
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Wessolowski, Axel [Verfasser]. "Amphipathische Hexapeptide - Interaktion mit Membranen = Amphipathic hexapeptides - interaction with membranes / von Axel Wessolowski." 2004. http://d-nb.info/971639035/34.

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Lin, Chih-Wei, and 林志韋. "Design and Synthesis of Amphipathic Polyproline Peptides with Antibacterial and Cell penetration Activity." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/s6f5e4.

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Tseng, Ya-Lin, and 曾雅琳. "How C-terminal residue alters the helix folding of an amphipathic antimicrobial peptide: CD and NMR study." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/4wmyjv.

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碩士<br>淡江大學<br>化學學系碩士班<br>102<br>One of the most interesting questions in biophysics is how protein sequences determine their unique three-dimensional structure. Previous studies reported that the residues at C-terminal can have effects on the protein folding behaviors. Since a large protein is highly complex, for simplicity, in this study we use MP-B (14 amino acids) and its analogues in 30% TFE-d3 aqueous solution as a model system. By using circular dichroism (CD) and NMR methods, we can get insight into how the C-terminal segment may influence the folding behavior of proteins. Spectra of CD
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Chou, Hung-Ta, and 周宏達. "Rational design of novel antimicrobial peptides with enhanced activity and selectivity based on structural parameters for amphipathic helical peptides." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/07494506083134834858.

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碩士<br>國立宜蘭大學<br>生物技術研究所碩士班<br>95<br>The extensive use of classical antibiotics has led to the growing emergence of many resistant strains of pathogenic microorganisms. Therefore, the development of novel therapeutic agents that could overcome the resistance problem has become critical. Evidence suggested that antimicrobial peptides (AMPs) are of greatest potential to represent such a new class of antibiotics. Cationic AMPs belong to the innate immune system and host defense mechanism of a wide range of living organisms. The largest group of AMPs comprises peptides which fold into an amphip
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CHUANG, SHUN-SHU, and 莊順淑. "Studies on the Contribution of the Amphipathic a-Helix A of the Abrin-a A Chain to its Structure and Function." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/45229352782757688576.

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碩士<br>國立臺灣大學<br>生化學研究所<br>87<br>SUMMARY Abrin is one of a type II RIPs, and it is composed of an enzymatic A chain with N-glycosidase activity, and a lectin B chain which binds to galactosylated proteins and lipids on the surface of the cells. The two polypeptide chains are linked by a disulfide bond. This hetro-dimeric plant toxins inhibits protein synthesis through depurination of 28S rRNA at position 4324, mediated through the N-glycosidase activity of the A chain, known as one of ribosome inactivating proteins (RIPs) . The N-glycosidase activity causes the impairment of bindin
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Williams, Cecelia V. "Mapping of the rotavirus nonstructural protein-4-caveolin-1 binding site to three hydrophobic residues within the extended, c-terminal amphipathic alpha helix." 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3258.

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Rotavirus NSP4, the first described viral enterotoxin, localizes to the plasma membrane of infected cells, possibly through interaction with caveolin-1. A direct interaction between NSP4 and caveolin-1, the structural protein of caveolae, was shown by yeast two-hybrid, peptide binding, and FRET analyses. To dissect the precise NSP4 binding domain to caveolin-1, mutants were prepared by altering either the charged or hydrophobic face of the NSP4 C-terminal amphipathic alpha-helix and examined for binding to caveolin-1. Replacing six charged residues with alanine (FLNSP4Ala) disrupted the charge
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Hsu, Chung-Yi, and 許鐘乙. "Synthesis, morphology and photophysical properties of amphipathic rod-coil poly[2,7-(9,9- dihexylfluorene)] -block-poly(2-vinyl pyridine) and its blending with inorganic nanoparticles." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/88114808712770458757.

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碩士<br>明志科技大學<br>化工與材料工程研究所<br>97<br>In this study, the amphiphilic PF-b-P2VP block copolymers with three different coil lengths, PF10-b-P2VP35, PF10-b-P2VP55, and PF10-b-P2VP75, were synthesized by ATRP. The effect of coil length, morphology in the dilute THF/MeOH solution, and heating temperature on the microstructure and photophysical properties of PF-b-P2VP was discussed. GPC, FTIR, and 1H NMR analysis indicated the successful synthesis of the desired amphiphilic PF-b-P2VP block copolymer with three different coil lengths. TEM analysis showed that the spherical micelles, worm-like micelles,
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