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Journal articles on the topic 'Amphipathic'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Hilgemann, Donald W., and Michael Fine. "Mechanistic analysis of massive endocytosis in relation to functionally defined surface membrane domains." Journal of General Physiology 137, no. 2 (2011): 155–72. http://dx.doi.org/10.1085/jgp.201010470.

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A large fraction of endocytosis in eukaryotic cells occurs without adaptors or dynamins. Here, we present evidence for the involvement of lipid domains in massive endocytosis (MEND) activated by both large Ca transients and amphipathic compounds in baby hamster kidney and HEK293 cells. First, we demonstrate functional coupling of the two MEND types. Ca transients can strongly facilitate detergent-activated MEND. Conversely, an amphipath with dual alkyl chains, ditridecylphthalate, is without effect in the absence of Ca transients but induces MEND to occur within seconds during Ca transients. C

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2

Ivanov, Andrei I., Alexandre A. Steiner, Shreya Patel, Alla Y. Rudaya та Andrej A. Romanovsky. "Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of α1-acid glycoprotein". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, № 4 (2005): R872—R878. http://dx.doi.org/10.1152/ajpregu.00514.2004.

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In view of the potential involvement of peripherally synthesized, circulating amphipathic mediators [such as platelet-activating factor (PAF) and prostaglandin E2] in the systemic inflammatory response to lipopolysaccharide (LPS), we hypothesized that transport of amphipaths by albumin is essential for conveying peripheral inflammatory signals to the brain. Our first specific aim was to test this hypothesis by studying LPS-induced fever and hypothermia in Nagase analbuminemic rats (NAR). NAR from two different colonies and normalbuminemic Sprague-Dawley rats were preimplanted with jugular cath

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3

Jin, Yi, Janet Hammer, Michelle Pate та ін. "Antimicrobial Activities and Structures of Two Linear Cationic Peptide Families with Various Amphipathic β-Sheet and α-Helical Potentials". Antimicrobial Agents and Chemotherapy 49, № 12 (2005): 4957–64. http://dx.doi.org/10.1128/aac.49.12.4957-4964.2005.

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ABSTRACT Many naturally occurring antimicrobial peptides comprise cationic linear sequences with the potential to adopt an amphipathic α-helical conformation. We designed a linear 18-residue peptide that adopted an amphipathic β-sheet structure when it was bound to lipids. In comparison to a 21-residue amphipathic α-helical peptide of equal charge and hydrophobicity, this peptide possessed more similar antimicrobial activity and greater selectivity in binding to and inducing leakage in vesicles composed of bacterial membrane lipids than vesicles composed of mammalian membrane lipids (J. Blazyk

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4

Elliott, W. L., C. J. Stille, L. J. Thomas, and R. E. Humphreys. "An hypothesis on the binding of an amphipathic, alpha helical sequence in Ii to the desetope of class II antigens." Journal of Immunology 138, no. 9 (1987): 2949–52. http://dx.doi.org/10.4049/jimmunol.138.9.2949.

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Abstract When we investigated the hypothesis that amphipathic alpha helical peptides digested from foreign antigen bind to class II major histocompatability complex (MHC) molecules' binding site (desetope) for foreign antigen to be presented to T cell receptors, we found such an extended amphipathic helix in Ii. This amphipathic helix was hypothesized to bind Ii to class II MHC antigens until release in endosomes containing digested foreign antigen. Then these amphipathic Ii polypeptides might polymerize so as not to compete with foreign antigen for binding to class II MHC molecules. Various s

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5

Varkey, Jobin, Jiantao Zhang, Junghyun Kim, et al. "An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles." Viruses 12, no. 12 (2020): 1466. http://dx.doi.org/10.3390/v12121466.

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Positive-strand RNA viruses universally remodel host intracellular membranes to form membrane-bound viral replication complexes, where viral offspring RNAs are synthesized. In the majority of cases, viral replication proteins are targeted to and play critical roles in the modulation of the designated organelle membranes. Many viral replication proteins do not have transmembrane domains, but contain single or multiple amphipathic alpha-helices. It has been conventionally recognized that these helices serve as an anchor for viral replication protein to be associated with membranes. We report her

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6

Gulsevin, Alican, and Jens Meiler. "Prediction of amphipathic helix—membrane interactions with Rosetta." PLOS Computational Biology 17, no. 3 (2021): e1008818. http://dx.doi.org/10.1371/journal.pcbi.1008818.

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Amphipathic helices have hydrophobic and hydrophilic/charged residues situated on opposite faces of the helix. They can anchor peripheral membrane proteins to the membrane, be attached to integral membrane proteins, or exist as independent peptides. Despite the widespread presence of membrane-interacting amphipathic helices, there is no computational tool within Rosetta to model their interactions with membranes. In order to address this need, we developed the AmphiScan protocol with PyRosetta, which runs a grid search to find the most favorable position of an amphipathic helix with respect to

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7

Kokeguchi, Susumu, Hiroyuki Ohta, Kazuhiro Fukui, Keijiro Kato, and Masachika Tsujimoto. "Amphipathic antigen fromEubacterium nodatum." FEMS Microbiology Letters 41, no. 1 (1987): 13–17. http://dx.doi.org/10.1111/j.1574-6968.1987.tb02133.x.

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8

McLean, L. R., J. L. Krstenansky, R. L. Jackson, K. A. Hagaman, K. A. Olsen, and J. E. Lewis. "Mixtures of synthetic peptides and dipalmitoylphosphatidylcholine as lung surfactants." American Journal of Physiology-Lung Cellular and Molecular Physiology 262, no. 3 (1992): L292—L300. http://dx.doi.org/10.1152/ajplung.1992.262.3.l292.

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Synthetic peptides that differ in their lipid-peptide interactions were combined with dipalmitoylphosphatidylcholine (DPPC) and tested in an adult rat lavaged lung model in vitro for efficacy as totally synthetic lung surfactants. The putative amphipathic alpha-helical region of the major lung surfactant apoprotein (SP-A81-102), an analogue with increased amphipathic alpha-helical potential ([Lys88,97,Glu99,Trp102]-SP-A81-102]), and the hydrophobic peptide gramicidin D were all ineffective. Three water-soluble lipid-binding peptides that contain amphipathic alpha-helical regions were also test

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9

Yu, Lianyuan, Yan Hu, Jinhong Duan, and Xian-Da Yang. "A Novel Approach of Targeted Immunotherapy against Adenocarcinoma Cells with Nanoparticles Modified by CD16 and MUC1 Aptamers." Journal of Nanomaterials 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/316968.

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Mucin 1 (MUC1) is a potentially important target of cancer therapy, being a glycoprotein that is overexpressed on cell surface of many types of adenocarcinomas, including breast, ovarian, colon, lung, and prostatic cancers. Several MUC1-targeted drug delivery systems have been developed and reported, but mobilizing natural killer cells (NK) to fight against MUC1-positive tumor has not been attempted. In this study, we introduced a novel amphipathic nanoparticle (NP) for enhancing the NK cytotoxicity to MUC1-positive cancer cells. The amphipathic NP had CD16 and MUC1 aptamers on its surface and

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10

Yang, Feng, Tiantian Li, Ziqing Peng, Yang Liu, and Yusong Guo. "The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations." Journal of Biological Chemistry 295, no. 49 (2020): 16643–54. http://dx.doi.org/10.1074/jbc.ra120.014999.

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The subcellular localization of Arf family proteins is generally thought to be determined by their corresponding guanine nucleotide exchange factors. By promoting GTP binding, guanine nucleotide exchange factors induce conformational changes of Arf proteins exposing their N-terminal amphipathic helices, which then insert into the membranes to stabilize the membrane association process. Here, we found that the N-terminal amphipathic motifs of the Golgi-localized Arf family protein, Arfrp1, and the endosome- and plasma membrane–localized Arf family protein, Arl14, play critical roles in spatial

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11

Pinigin, Konstantin V., and Sergey A. Akimov. "The Membrane-Mediated Interaction of Liquid-Ordered Lipid Domains in the Presence of Amphipathic Peptides." Membranes 13, no. 10 (2023): 816. http://dx.doi.org/10.3390/membranes13100816.

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The lipid membranes of living cells are composed of a large number of lipid types and can undergo phase separation with the formation of nanometer-scale liquid-ordered lipid domains, also called rafts. Raft coalescence, i.e., the fusion of lipid domains, is involved in important cell processes, such as signaling and trafficking. In this work, within the framework of the theory of elasticity of lipid membranes, we explore how amphipathic peptides adsorbed on lipid membranes may affect the domain–domain fusion processes. We show that the elastic deformations of lipid membranes drive amphipathic

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12

Puig-Basagoiti, Francesc, Takasuke Fukuhara, Tomokazu Tamura, et al. "Human Cathelicidin Compensates for the Role of Apolipoproteins in Hepatitis C Virus Infectious Particle Formation." Journal of Virology 90, no. 19 (2016): 8464–77. http://dx.doi.org/10.1128/jvi.00471-16.

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ABSTRACTExchangeable apolipoproteins (ApoA, -C, and -E) have been shown to redundantly participate in the formation of infectious hepatitis C virus (HCV) particles during the assembly process, although their precise role in the viral life cycle is not well understood. Recently, it was shown that the exogenous expression of only short sequences containing amphipathic α-helices from various apolipoproteins is sufficient to restore the formation of infectious HCV particles in ApoB and ApoE double-gene-knockout Huh7 (BE-KO) cells. In this study, through the expression of a small library of human s

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13

Pazderková, Markéta, Eva Kočišová, Tomáš Pazderka, et al. "Antimicrobial Peptide from the Eusocial BeeHalictus sexcinctusInteracting with Model Membranes." Spectroscopy: An International Journal 27 (2012): 497–502. http://dx.doi.org/10.1155/2012/840956.

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Halictine-1 (Hal-1)—a linear antibacterial dodecapeptide isolated from the venom of the eusocial beeHalictus sexcinctus—has been subjected to a detailed spectroscopic study including circular dichroism, fluorescence, and vibrational spectroscopy. We investigated Hal-1 ability to adopt an amphipathicα-helical structure upon interaction with model lipid-based bacterial membranes (phosphatidylcholine/phosphatidylglycerol-based large unilamellar vesicles and sodium dodecylsulfate micelles) and helix inducing components (trifluoroethanol). It was found that Hal-1 responds sensitively to the composi

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14

HU, A. Liaoyuan, and C. Steven KING. "Functional sensitivity of polar surfaces on transmembrane helix 8 and cytoplasmic loop 8-9 of the Escherichia coli GABA (4-aminobutyrate) transporter encoded by gabP: mutagenic analysis of a consensus amphipathic region found in transporters from bacteria to mammals." Biochemical Journal 330, no. 2 (1998): 771–76. http://dx.doi.org/10.1042/bj3300771.

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The gab permease (GabP) catalyses transport of GABA (4-aminobutyrate) into Escherichia coli. Although GabP can recognize and transport many GABA analogues that exhibit activity at GABAergic synapses in the nervous system, the protein domains responsible for these transport and ligand recognition properties have not been studied. Here we report that an amphipathic domain extending through putative transmembrane helix 8 and into the adjoining cytoplasmic region (loop 8-9) contains a critical 20 residue zone within which mutagenesis of polar amino acids has a deleterious effect on [3H]GABA transp

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15

Hallett, Barbara P., and J. Derek Bewley. "Membranes and seed dormancy: beyond the anaesthetic hypothesis." Seed Science Research 12, no. 2 (2002): 69–82. http://dx.doi.org/10.1079/ssr200299.

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The breaking of dormancy in seeds can be elicited by many factors, including temperature and short exposure to low molecular weight amphipathic molecules such as primary alcohols, monocarboxylic acids and anaesthetics. Their action has been suggested to be mediated through effecting changes to membranes. Paradoxically, though, these molecules can inhibit the germination of some non-dormant seeds. Here, we review the structure–activity relationships between amphipathic molecules and dormancy breaking and, based on the known responses of membranes to them and to temperature changes, offer an alt

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16

Giangaspero, Anna, Luca Sandri та Alessandro Tossi. "Amphipathic α helical antimicrobial peptides." European Journal of Biochemistry 268, № 21 (2001): 5589–600. http://dx.doi.org/10.1046/j.1432-1033.2001.02494.x.

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17

HAGA, Kazuo, Yoshiro KASHIZAKI, and Ryohei KANEKO. "Polymerization of an amphipathic monomer." KOBUNSHI RONBUNSHU 46, no. 7 (1989): 421–26. http://dx.doi.org/10.1295/koron.46.421.

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18

Cox, Charles D., and Philip A. Gottlieb. "Amphipathic molecules modulate PIEZO1 activity." Biochemical Society Transactions 47, no. 6 (2019): 1833–42. http://dx.doi.org/10.1042/bst20190372.

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PIEZO proteins are large eukaryotic mechanically-gated channels that function as homotrimers. The basic PIEZO1 structure has been elucidated by CryoEM and it assembles into a protein–lipid dome. A curved lipid region allows for the transition to the lipid bilayer from the dome (footprint). Gating PIEZO1 is mediated by bilayer tension that induces an area change in the lipid dome. The footprint region is thought to be energetically important for changes in lateral tension. Amphipathic molecules can modulate channel function beyond the intrinsic gating properties of PIEZO1. As a result, molecule

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19

Cheng, Yuen-Kit, Wen-Shyan Sheu, and Peter J. Rossky. "Hydrophobic Hydration of Amphipathic Peptides." Biophysical Journal 76, no. 4 (1999): 1734–43. http://dx.doi.org/10.1016/s0006-3495(99)77335-2.

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20

Takeda, Takashi, Shunsuke Yamamoto, Masaya Mitsuishi, and Tomoyuki Akutagawa. "Thermoresponsive Amphipathic Fluorescent Organic Liquid." Journal of Physical Chemistry C 122, no. 17 (2018): 9593–98. http://dx.doi.org/10.1021/acs.jpcc.8b01131.

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21

Drin, Guillaume, and Bruno Antonny. "Amphipathic helices and membrane curvature." FEBS Letters 584, no. 9 (2009): 1840–47. http://dx.doi.org/10.1016/j.febslet.2009.10.022.

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22

Cornut, Isabelle, Klaus Büttner, Jean-Louis Dasseux та Jean Dufourcq. "The amphipathic α-helix concept". FEBS Letters 349, № 1 (1994): 29–33. http://dx.doi.org/10.1016/0014-5793(94)00621-0.

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23

Fernández-Carneado, Jimena, Marcelo J. Kogan, Silvia Pujals, and Ernest Giralt. "Amphipathic peptides and drug delivery." Biopolymers 76, no. 2 (2004): 196–203. http://dx.doi.org/10.1002/bip.10585.

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24

Tossi, Alessandro, Luca Sandri та Anna Giangaspero. "Amphipathic, α-helical antimicrobial peptides". Biopolymers 55, № 1 (2000): 4–30. http://dx.doi.org/10.1002/1097-0282(2000)55:1<4::aid-bip30>3.0.co;2-m.

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25

Klousnitzer, Jessie, Wenyu Xiang, Vania M. Polynice, and Berthony Deslouches. "Comparative Properties of Helical and Linear Amphipathicity of Peptides Composed of Arginine, Tryptophan, and Valine." Antibiotics 13, no. 10 (2024): 954. http://dx.doi.org/10.3390/antibiotics13100954.

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Background: The persistence of antibiotic resistance has incited a strong interest in the discovery of agents with novel antimicrobial mechanisms. The direct killing of multidrug-resistant bacteria by cationic antimicrobial peptides (AMPs) underscores their importance in the fight against infections associated with antibiotic resistance. Despite a vast body of AMP literature demonstrating a plurality in structural classes, AMP engineering has been largely skewed toward peptides with idealized amphipathic helices (H-amphipathic). In contrast to helical amphipathicity, we designed a series of pe

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Hashimoto, Masayoshi, Ken Komatsu, Ryo Iwai, et al. "Cell Death Triggered by a Putative Amphipathic Helix of Radish mosaic virus Helicase Protein Is Tightly Correlated With Host Membrane Modification." Molecular Plant-Microbe Interactions® 28, no. 6 (2015): 675–88. http://dx.doi.org/10.1094/mpmi-01-15-0004-r.

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Systemic necrosis is one of the most severe symptoms caused by plant RNA viruses. Recently, systemic necrosis has been suggested to have similar features to a defense response referred to as the hypersensitive response (HR), a form of programmed cell death. In virus-infected plant cells, host intracellular membrane structures are changed dramatically for more efficient viral replication. However, little is known about whether this replication-associated membrane modification is the cause of the symptoms. In this study, we identified an amino-terminal amphipathic helix of the helicase encoded b

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Han, S., J. Wang, K. Meng, et al. "Preparation, gradient extraction and surface polarity-dependent antibacterial properties of cockscomb seeds-derived carbon dots." Digest Journal of Nanomaterials and Biostructures 17, no. 3 (2022): 771. http://dx.doi.org/10.15251/djnb.2022.173.771.

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Cockscomb seeds-derived carbon dots (CSCDs) were fabricated by hydrothermal method with common cockscomb seeds. The prepared CSCDs exhibit selectively antibacterial properties towards Gram-positive bacterias, such as Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). Then, the CSCDs were separated to three groups with lipophilic, amphipathic and hydrophilic ones by simple gradient extraction. Interestingly, the three groups of CSCDs exhibited different antibacterial activities, and the amphipathic CSCDs(ACSCDs) showed best bacterial inhibition. This phenomenon m

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Jarrin, Miguel, Alexia A. Kalligeraki, Alice Uwineza, et al. "Independent Membrane Binding Properties of the Caspase Generated Fragments of the Beaded Filament Structural Protein 1 (BFSP1) Involves an Amphipathic Helix." Cells 12, no. 12 (2023): 1580. http://dx.doi.org/10.3390/cells12121580.

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Background: BFSP1 (beaded filament structural protein 1) is a plasma membrane, Aquaporin 0 (AQP0/MIP)-associated intermediate filament protein expressed in the eye lens. BFSP1 is myristoylated, a post-translation modification that requires caspase cleavage at D433. Bioinformatic analyses suggested that the sequences 434–452 were α-helical and amphipathic. Methods and Results: By CD spectroscopy, we show that the addition of trifluoroethanol induced a switch from an intrinsically disordered to a more α-helical conformation for the residues 434–467. Recombinantly produced BFSP1 fragments contain

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29

Fine, Michael, Marc C. Llaguno, Vincenzo Lariccia, Mei-Jung Lin, Alp Yaradanakul, and Donald W. Hilgemann. "Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: a new approach to membrane recycling and lipid domains." Journal of General Physiology 137, no. 2 (2011): 137–54. http://dx.doi.org/10.1085/jgp.201010469.

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The roles that lipids play in endocytosis are the subject of debate. Using electrical and imaging methods, we describe massive endocytosis (MEND) in baby hamster kidney (BHK) and HEK293 cells when the outer plasma membrane monolayer is perturbed by the nonionic detergents, Triton X-100 (TX100) and NP-40. Some alkane detergents, the amphipathic drugs, edelfosine and tamoxifen, and the phospholipase inhibitor, U73122, are also effective. Uptake of the membrane tracer, FM 4–64, into vesicles and loss of reversible FM 4–64 binding confirm that 40–75% of the cell surface is internalized. Ongoing ME

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Hertz, R., and J. Bar−Tana. "The acylation of proteins by xenobiotic amphipathic carboxylic acids in cultured rat hepatocytes." Biochemical Journal 254, no. 1 (1988): 39–44. http://dx.doi.org/10.1042/bj2540039.

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Three xenobiotic amphipathic carboxylates, namely MEDICA 16, nafenopin and bezafibrate, which differ remarkably in their hydrophobic backbones, were found to acylate membrane and cytosolic liver proteins in cultured rat hepatocytes. The acylation patterns observed were time- and dose-dependent, and the acylated residue consisted of the original xenobiotic. The acylation patterns generated by the three xenobiotic carboxylates included common proteins which were acylated by the three xenobiotics (e.g. proteins of 32, 52, 56 and 72 kDa) as well as unique proteins which were specifically acylated

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Teterina, Natalya L., Eric Levenson, Mario S. Rinaudo, et al. "Evidence for Functional Protein Interactions Required for Poliovirus RNA Replication." Journal of Virology 80, no. 11 (2006): 5327–37. http://dx.doi.org/10.1128/jvi.02684-05.

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ABSTRACT Poliovirus protein 2C contains a predicted N-terminal amphipathic helix that mediates association of the protein with the membranes of the viral RNA replication complex. A chimeric virus that contains sequences encoding the 18-residue core from the orthologous amphipathic helix from human rhinovirus type 14 (HRV14) was constructed. The chimeric virus exhibited defects in viral RNA replication and produced minute plaques on HeLa cell monolayers. Large plaque variants that contained mutations within the 2C-encoding region were generated upon subsequent passage. However, the majority of

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Kondrashov, Oleg V., and Sergey A. Akimov. "Alteration of Average Thickness of Lipid Bilayer by Membrane-Deforming Inclusions." Biomolecules 13, no. 12 (2023): 1731. http://dx.doi.org/10.3390/biom13121731.

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Thickness of lipid bilayer membranes is a key physical parameter determining membrane permeability and stability with respect to formation of through pores. Most membrane inclusions or impurities like amphipathic peptides, transmembrane peptides, lipid inclusions of a different molecular shape, lipid domains, and protein-lipid domains, locally deform the membrane. The detailed structure of the locally deformed region of the membrane is a kind of “fingerprint” for the inclusion type. However, most experimental methods allow determining only averaged parameters of membranes with incorporated inc

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Zhang, Linsheng, Jianqun Lin, and Guangyong Ji. "Membrane Anchoring of the AgrD N-terminal Amphipathic Region Is Required for Its Processing to Produce a Quorum-sensing Pheromone inStaphylococcus aureus." Journal of Biological Chemistry 279, no. 19 (2004): 19448–56. http://dx.doi.org/10.1074/jbc.m311349200.

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Quorum-sensing pheromones are signal molecules that are secreted from Gram-positive bacteria and utilized by these bacteria to communicate among individual cells to regulate their activities as a group through a cell density-sensing mechanism. Typically, these pheromones are processed from precursor polypeptides. The mechanisms of trafficking, processing, and modification of the precursor to generate a mature pheromone are unclear. InStaphylococcus aureus, AgrD is the propeptide for an autoinducing peptide (AIP) pheromone that triggers the Agr cell density-sensing system upon reaching a thresh

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Margalit, H., J. L. Spouge, J. L. Cornette, K. B. Cease, C. Delisi, and J. A. Berzofsky. "Prediction of immunodominant helper T cell antigenic sites from the primary sequence." Journal of Immunology 138, no. 7 (1987): 2213–29. http://dx.doi.org/10.4049/jimmunol.138.7.2213.

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Abstract We have used a data base of 23 known immunodominant helper T cell antigenic sites located on 12 proteins to systematically develop an optimized algorithm for predicting T cell antigenic sites. The algorithm is based on the amphipathic helix model in which antigenic sites are postulated to be helices with one face predominantly polar and the opposite face predominantly apolar. Such amphipathic structures can form when the polarity of residues along the sequence varies with a more or less regular period. Hence they can be identified by methods (so called power spectrum procedures) that

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35

Graham, Ben, Alice E. R. Fayter, Judith E. Houston, Rachel C. Evans, and Matthew I. Gibson. "Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization." Journal of the American Chemical Society 140, no. 17 (2018): 5682–85. http://dx.doi.org/10.1021/jacs.8b02066.

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Reddy, Srinivasa T., G. M. Anantharamaiah, Mohamad Navab, et al. "Oral amphipathic peptides as therapeutic agents." Expert Opinion on Investigational Drugs 15, no. 1 (2005): 13–21. http://dx.doi.org/10.1517/13543784.15.1.13.

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Giménez-Andrés, Manuel, Alenka Čopič, and Bruno Antonny. "The Many Faces of Amphipathic Helices." Biomolecules 8, no. 3 (2018): 45. http://dx.doi.org/10.3390/biom8030045.

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Amphipathic helices (AHs), a secondary feature found in many proteins, are defined by their structure and by the segregation of hydrophobic and polar residues between two faces of the helix. This segregation allows AHs to adsorb at polar–apolar interfaces such as the lipid surfaces of cellular organelles. Using various examples, we discuss here how variations within this general scheme impart membrane-interacting AHs with different interfacial properties. Among the key parameters are: (i) the size of hydrophobic residues and their density per helical turn; (ii) the nature, the charge, and the

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Gutnick, D. L., R. Avigad, Y. Blatt, W. Minas, and R. Allon. "Amphipathic microbial capsules as industrial products." Journal of Applied Bacteriology 74 (June 1993): 125S—135S. http://dx.doi.org/10.1111/j.1365-2672.1993.tb04349.x.

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Moussa, D. G., J. A. Kirihara, Z. Ye, et al. "Dentin Priming with Amphipathic Antimicrobial Peptides." Journal of Dental Research 98, no. 10 (2019): 1112–21. http://dx.doi.org/10.1177/0022034519863772.

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The evolution of bonded restorations has undergone great progress over several decades. Nonetheless, life spans of bonded restorations are limited mainly because of the eventual incidence of recurrent caries. Over time, water and waterborne agents (acids, enzymes) degrade the components of the dentin/restoration interface, allowing bacterial colonization and dentin reinfection at the margins of the restoration. We developed a 2-tier protective technology consisting of priming/coating dentin with amphipathic and antimicrobial peptides (AAMPs) to obtain hydrophobic/water-repellent and antibiofil

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Petter, Russell C., and Jeffrey S. Salek. "Cooperative binding by an amphipathic host." Journal of the American Chemical Society 109, no. 25 (1987): 7897–99. http://dx.doi.org/10.1021/ja00259a057.

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Jiang, Xuesong, Jue Luo, and Jie Yin. "A novel amphipathic polymeric thioxanthone photoinitiator." Polymer 50, no. 1 (2009): 37–41. http://dx.doi.org/10.1016/j.polymer.2008.10.038.

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Ramaswamy, C., and A. T. Florence. "Self-assembly of some amphipathic dendrons." Journal of Drug Delivery Science and Technology 15, no. 4 (2005): 307–11. http://dx.doi.org/10.1016/s1773-2247(05)50054-6.

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Wood, Laura A., and Stephen J. Royle. "Zero Tolerance: Amphipathic Helices in Endocytosis." Developmental Cell 33, no. 2 (2015): 119–20. http://dx.doi.org/10.1016/j.devcel.2015.04.007.

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Bach, Horacio, and David L. Gutnick. "Novel polysaccharide–protein-based amphipathic formulations." Applied Microbiology and Biotechnology 71, no. 1 (2006): 34–38. http://dx.doi.org/10.1007/s00253-005-0149-9.

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Nango, Mamoru, Kouji Lida, Tomoki Kawakita, et al. "Characterization of amphipathic fluorinated porphyrin derivatives." Journal of the Chemical Society, Chemical Communications, no. 7 (1992): 545. http://dx.doi.org/10.1039/c39920000545.

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Jensen, Martin Borch, Vikram Kjøller Bhatia, Christine C. Jao, et al. "Membrane Curvature Sensing by Amphipathic Helices." Journal of Biological Chemistry 286, no. 49 (2011): 42603–14. http://dx.doi.org/10.1074/jbc.m111.271130.

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Pujals, Sílvia, and Ernest Giralt. "Proline-rich, amphipathic cell-penetrating peptides." Advanced Drug Delivery Reviews 60, no. 4-5 (2008): 473–84. http://dx.doi.org/10.1016/j.addr.2007.09.012.

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Lyman, Edward, and Alexander J. Sodt. "Amphipathic Helices—Wedge? Or Nae Nae?" Biophysical Journal 110, no. 1 (2016): 1–2. http://dx.doi.org/10.1016/j.bpj.2015.11.3513.

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Segrest, Jere P., Hans De Loof, Jan G. Dohlman, Christie G. Brouillette, and G. M. Anantharamaiah. "Amphipathic helix motif: Classes and properties." Proteins: Structure, Function, and Genetics 8, no. 2 (1990): 103–17. http://dx.doi.org/10.1002/prot.340080202.

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Liu, Jikang, Xiaoguang Zhu, Junli Li, Jiulin Shen, and Guoli Tu. "Enhancing the thermal stability of the bulk-heterojunction photovoltaics based on P3HT/PCBM by incorporating diblock amphipathic P3HT–PEO at D/A interface." RSC Advances 6, no. 66 (2016): 61934–43. http://dx.doi.org/10.1039/c6ra08385d.

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