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Journal articles on the topic 'Antimicrobial Resistance AMR Antibiotics'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Madhuri, Patel1 Akash Golaviya2* Bharat Bhanderi2 and Harshrajsinh Joddha2. "Mechanisms of Antimicrobial Resistance (AMR) in Bacteria." Science World a monthly e magazine 2, no. 11 (2022): 1918–22. https://doi.org/10.5281/zenodo.7373277.

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Antimicrobial resistance (AMR) is recognized as one of the major global health challenges and “ticking time bomb” of the 21<sup>st</sup> century. The resistance of bacteria to antibiotics hinders the efficiency of antibiotic use in the health care, and there is significant evidence to prove that the misuse of antibiotics will eventually result in the development of resistance. The clinical pipeline of new antimicrobials is dry, the last new class of antibiotic (daptomycin) approved in 2003 by the US FDA. This fact confirms that antimicrobial agents found on the market in the last 3

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Enshaie, Elliot, Sankalp Nigam, Shaan Patel, and Vikrant Rai. "Livestock Antibiotics Use and Antimicrobial Resistance." Antibiotics 14, no. 6 (2025): 621. https://doi.org/10.3390/antibiotics14060621.

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Background/Objectives: Antibiotic resistance or antimicrobial resistance (AMR) in livestock is a growing global concern that threatens both human and animal health. The overuse and misuse of antibiotics in livestock production have led to an increased propensity for the development of AMR bacterial strains in animals, which can be spread to humans through the consumption of contaminated animal products, direct contact, or environmental exposure. This review aims to summarize the development and transmission of AMR in livestock, explore its underlying mechanisms and impact on human and animal h

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Jolaoso, Adeyemi Olufunmilayo, Michael Agbaje, Olajoju Awoyomi, Bernard Onoja, and Olufemi Ernest Ojo. "Awareness of Antimicrobial Resistance and Antimicrobial Drugs Prescription Pattern in Small Animal Clinical Practice in Ogun State, Nigeria." Nigerian Veterinary Journal 45, no. 1 (2024): 1–11. http://dx.doi.org/10.4314/nvj.v45i1.2.

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Antimicrobial resistance (AMR) is a global health challenge in veterinary and human health, leading to monitoring of resistance and promotion of responsible antimicrobial use. This survey assessed the use of antimicrobials among government veterinarians in Ogun state, Nigeria. Clinicians were requested to fill questionnaires designed to extract information on the frequency of antibiotics use, antibiotic prescription patterns and evaluation of perception on AMR and use of antibiotics with compromised efficacy in veterinary practice in the last three years. Fifty-two (52) questionnaires were adm

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AB, Upaganlawar. "Impact of Antimicrobial Resistance in Health and Economic Outcomes: A Review." Advances in Pharmacology and Clinical Trials 9, no. 2 (2024): 1–10. http://dx.doi.org/10.23880/apct-16000234.

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Background: Antimicrobial resistance (AMR) observed when microorganism adapt and multiply in the presence of drugs to which they are exposed. Antibiotic resistance is a global health problem, with the current trend of inappropriate and overuse of antibiotics predicted to cause 10 million deaths by 2050. However, resistant bacteria are multiplying worldwide, infecting healthy people, animals, and human environment, affecting countries with low- and middle-income countries. Although the discovery of antibiotics has saved many lives in recent years, increasing bacterial resistance to antibiotics

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Shraddha, Shinde* Jha Urmilesh Mansukh G. A. Chetana Padekar Pratiksha Bhosale Sarika Pawar Ganesh Gosavi Amol Darade. "Antimicrobial Resistance: Challenges And Future Prospects." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 492–500. https://doi.org/10.5281/zenodo.15143021.

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Antibiotic abuse and misuse across a range of industries contribute to the creation of resistant bacteria, which in turn causes antimicrobial resistance (AMR), a serious worldwide health concern. The discovery of penicillin marked the beginning of antimicrobial resistance (AMR), and the emergence of multidrug-resistant bacteria has presented serious problems for healthcare systems around the globe. A "Silent Pandemic" that may outnumber other causes of death by 2050 is being created by the overuse of antibiotics in agriculture, human health, and animal health. This adds to the spread of resist

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Alam, Mohammad Morshad, Muzahidul Islam, Abrar Wahab, and Mamun Billah. "Antimicrobial Resistance Crisis and Combating Approaches." Journal of Medicine 20, no. 1 (2019): 38–45. http://dx.doi.org/10.3329/jom.v20i1.38842.

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Antimicrobial resistance is a major global public health challenge threatening the utility of antibiotics. Inappropriate antibiotic prescribing and sales, using outside of the health sectors, and genetic factors are mainly influencing the development of antimicrobial resistance (AMR). Antibiotics abuse in human, wildlife, and farming practices have an enormous health impact. Recently approved antibiotics are anticipated to help stem this crisis. To fight against antibiotic resistance crisis, development of collaboration among concerned stakeholders to establish policies, initiatives, and inves

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Kalın, Gamze, Emine Alp, Arthur Chouaikhi, and Claire Roger. "Antimicrobial Multidrug Resistance: Clinical Implications for Infection Management in Critically Ill Patients." Microorganisms 11, no. 10 (2023): 2575. http://dx.doi.org/10.3390/microorganisms11102575.

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The increasing incidence of antimicrobial resistance (AMR) worldwide represents a serious threat in the management of sepsis. Due to resistance to the most common antimicrobials prescribed, multidrug-resistant (MDR) pathogens have been associated with delays in adequate antimicrobial therapy leading to significant increases in mortality, along with prolonged hospital length of stay (LOS) and increases in healthcare costs. In response to MDR infections and the delay of microbiological results, broad-spectrum antibiotics are frequently used in empirical antimicrobial therapy. This can contribute

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Manjunath, BC, BR Chandrashekar, RRM Vatchala, et al. "Addressing Antimicrobial Resistance in Dentistry." Journal of Oral Health and Community Dentistry 7, no. 2 (2013): 101–7. http://dx.doi.org/10.5005/johcd-7-2-101.

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ABSTRACT Background Antimicrobial agents are life saving drugs which are used in management of various life threatening infections but irrational use of antibiotics have led to resurgence of multidrug resistant bacteria which are associated with global increase in mortality due to various infections. Dentists are one among important health care personnel who prescribe antibiotics routinely to treat various oral infections. Objectives To summarise the evidence of antimicrobial resistance (AMR) encountered in dental practice, discuss factors associated with it and suggest measures to prevent ant

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Akshat, Markam* Swati Khare Dr. Jitendra Banweer. "Antimicrobial Resistance: Impacts, Challenges, and Future Prospects." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4527–35. https://doi.org/10.5281/zenodo.15535325.

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Antimicrobial resistance (AMR) is a global health concern driven by the misuse and overuse of antibiotics in various industries, leading to the emergence of resistant microorganisms. The history of AMR dates back to the discovery of penicillin, with the emergence of multidrug-resistant pathogens posing serious challenges to healthcare systems worldwide. Antibiotic abuse in human and veterinary medicine, agriculture, and animal husbandry contributes to the spread of resistance genes, causing a "Silent Pandemic" that can be larger than other mortality causes by 2050. Humans and animals are both

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Nojek, Paweł, Mariusz Zimonczyk, Monika Zawół, Wiktoria Pawlik, Gustaw Błaszczyński, and Agnieszka Nowotarska. "The Impact of prolonged antibiotic use on the development of bacterial resistance - a literature review." Journal of Education, Health and Sport 71 (November 21, 2024): 56137. http://dx.doi.org/10.12775/jehs.2024.71.56137.

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Abstract Introduction and Objective. Antimicrobial resistance (AMR) arises when pathogens no longer respond to antimicrobials, including antibiotics, making infections harder to treat and increasing the risks of severe illness and death. Although AMR is a natural evolutionary process, human activities, especially the misuse of antimicrobials in healthcare, agriculture, and animal care, accelerate its spread. This review examines the impact of prolonged antibiotic use on bacterial resistance and analyzes global trends and strategies to combat AMR. Methods. A literature review was conducted usin

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Fadia, Falah Hassan*, Alaa Al Aamery Rana, and Khalil Ibrahim Marwa. "DRUG RESISTANCE: THE ALARM OF NEW CHALLENGE AND ALTERNATIVE APPROACHES." World Journal of Pharmaceutical Science and Research 2, no. 6 (2023): 121–33. https://doi.org/10.5281/zenodo.10935493.

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The significant morbidity and mortality resulting from antimicrobial resistance in bacterial infections is a concern within the medical community. The emergence of multidrug-resistant Gram-positive and Gram-negative bacteria poses a considerable challenge in treatment, as these strains may exhibit resistance even toward conventional medications. Given the lack of efficacious treatments, preventative measures, and novel antibiotics, bacterial infections and their associated diseases present formidable obstacles that necessitate the exploration and development of innovative therapeutic alternati

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Dr., Prasad Katare* Sourav Singh Aryan Niraj Kumar Nangare Mahesh Mande Sandip. "Pharmacological Approaches to Combatting Antimicrobial Resistance (Amr)." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 1923–32. https://doi.org/10.5281/zenodo.14722593.

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Antimicrobial resistance (AMR) has emerged as a critical global health challenge, threatening the effectiveness of many commonly used antibiotics and complicating the treatment of infections. The overuse and misuse of antibiotics in human medicine, agriculture and veterinary practice have led to the accelerated development of resistant pathogens. This review paper explores the pharmacological approaches to combat AMR, including current strategies such as drug modifications, combination therapies and beta-lactamase inhibitors. These approaches aim to restore the efficacy of existing antibiotics

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Zgliczyński, Wojciech Stefan, Jarosław Bartosiński, and Olga Maria Rostkowska. "Knowledge and Practice of Antibiotic Management and Prudent Prescribing among Polish Medical Doctors." International Journal of Environmental Research and Public Health 19, no. 6 (2022): 3739. http://dx.doi.org/10.3390/ijerph19063739.

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Antimicrobial resistance (AMR) is an urgent public health issue. The role of medical doctors in proper antibiotic use is crucial. The aim of this study was to evaluate the knowledge and practices of Polish doctors of antimicrobial prescribing and antibiotic resistance. The study group consisted of 504 medical doctors with an average age 32.8 ± 5.9 years, mostly women (65%). The paper questionnaire was developed on the basis of a survey tool developed by the European Centre for Disease Prevention and Control (ECDC) and Public Health England (PHE). According to our study, physicians were aware t

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Dr., Shalini Pandey &. Dr. R.P. Diwakar. "ANTIMICROBIAL RESISTANCE: A SERIOUS THREAT FOR ALL." MULTILOGIC IN SCIENCE XXXXVIII, Oct 2023 (2023): 1062–63. https://doi.org/10.5281/zenodo.8409689.

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Antimicrobial Resistance (AMR) occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines making infections harder to treat and increasing the risk of disease spread, severe illness and death. As a result of drug resistance, antibiotics and other antimicrobial medicines become ineffective and infections become increasingly difficult or impossible to treat. The emergence and spread of drug-resistant pathogens that have acquired new resistance mechanisms, leading to antimicrobial resistance, continues to threaten our ability to treat common infections.

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Sanika, Chougule. "The Evaluation of Antibiotic Resistance: Mechanisms, Challenges, and Future Directions." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 749–56. https://doi.org/10.5281/zenodo.14173879.

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An antibiotic is a type of medication designed to kill or inhibit the growth of bacteria, helping to treat bacterial infections in humans, animals, and sometimes plants. Antibiotics work by targeting specific components of bacterial cells, such as cell walls, protein synthesis, or DNA replication, thereby preventing bacteria from growing or killing them directly. Antibiotics are not effective against viruses, so they should not be used to treat viral infections like the flu or common cold. Antibiotic resistance has become a major global health concern that threatens the efficacy of treatments

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C.S., Baiju, and Pandey Diya. "Antimicrobial Resistance (AMR) and Dentistry: A lethal connect." World Journal of Advanced Research and Reviews 22, no. 3 (2024): 1600–1610. https://doi.org/10.5281/zenodo.14755759.

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In the unfolding narrative of global health, the ominous spectre of antimicrobial resistance (AMR) looms large, presenting an ever more urgent challenge to public health systems worldwide. Antibiotics are a primary tool in the field of therapeutic medicine & dentistry & they saturate the Indian pharmaceutical markets. Dentistry places substantial reliance on use of antibiotics in prophylaxis & therapy, but this dependence contributes to the overuse & misuse of these drugs. A significant number of prescriptions are frequently deemed superfluous.  Furthermore, antibiotics ar

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Ćirković, Ivana, and Milena Švabić-Vlahović. "Nosocomial antibiotic strain resistance." Galenika Medical Journal 1, no. 3 (2022): 60–68. http://dx.doi.org/10.5937/galmed2203060c.

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Antimicrobial resistance (AMR) is the ability of a microorganism to acquire resistance to various antimicrobial drugs (antibiotics, antiviral drugs, antifungals and antiparasitic drugs). The greatest attention of the world public in the previous decades was on the resistance of bacteria to antibiotics, and the forecast for the next decades that we will "wear out the existing antibiotics" and return to the pre-antibiotic era. Excessive use or abuse of antibiotics is associated with the emergence and spread of antibiotic resistance among bacteria, making treatment ineffective and posing a seriou

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Bhavani, Puvvala1 Esha sinha2 Koppu Vasavi3 Poloju Deepa4 Madineni Kavitha5. "Antimicrobial resistance: what is it?" Science World a monthly e magazine 2, no. 11 (2022): 1953–59. https://doi.org/10.5281/zenodo.7387252.

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Antimicrobial resistance is an important concern for public health authorities at a global level. When bacteria, fungi, viruses, and parasites (as well as other microbes) are subjected to antimicrobial drugs that are intended to either kill them or restrict their growth, they develop the ability to resist such drugs, which is known as antimicrobial resistance (such as antibiotics, antifungals, antivirals, antimalarials, and anthelmintics). As a result, the medications stop working and diseases continue to exist in the body, raising the possibility that they will spread to other people. Antibio

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Marzaman, Ardiyah Nurul Fitri, Tri Puspita Roska, Sartini Sartini, et al. "Recent Advances in Pharmaceutical Approaches of Antimicrobial Agents for Selective Delivery in Various Administration Routes." Antibiotics 12, no. 5 (2023): 822. http://dx.doi.org/10.3390/antibiotics12050822.

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Globally, the increase of pathogenic bacteria with antibiotic-resistant characteristics has become a critical challenge in medical treatment. The misuse of conventional antibiotics to treat an infectious disease often results in increased resistance and a scarcity of effective antimicrobials to be used in the future against the organisms. Here, we discuss the rise of antimicrobial resistance (AMR) and the need to combat it through the discovery of new synthetic or naturally occurring antibacterial compounds, as well as insights into the application of various drug delivery approaches delivered

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Ko, Humphrey H. T., Ricky R. Lareu, Brett R. Dix, and Jeffery D. Hughes. "Statins: antimicrobial resistance breakers or makers?" PeerJ 5 (October 24, 2017): e3952. http://dx.doi.org/10.7717/peerj.3952.

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IntroductionThe repurposing of non-antibiotic drugs as adjuvant antibiotics may help break antimicrobial resistance (AMR). Statins are commonly prescribed worldwide to lower cholesterol. They also possess qualities of AMR “breakers”, namely direct antibacterial activity, synergism with antibiotics, and ability to stimulate the host immune system. However, statins’ role as AMR breakers may be limited. Their current extensive use for cardiovascular protection might result in selective pressures for resistance, ironically causing statins to be AMR “makers” instead. This review examines statins’ p

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C.S. Baiju and Diya Pandey. "Antimicrobial Resistance (AMR) and Dentistry: A lethal connect." World Journal of Advanced Research and Reviews 22, no. 3 (2024): 1600–1610. http://dx.doi.org/10.30574/wjarr.2024.22.3.1905.

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In the unfolding narrative of global health, the ominous spectre of antimicrobial resistance (AMR) looms large, presenting an ever more urgent challenge to public health systems worldwide. Antibiotics are a primary tool in the field of therapeutic medicine & dentistry & they saturate the Indian pharmaceutical markets. Dentistry places substantial reliance on use of antibiotics in prophylaxis & therapy, but this dependence contributes to the overuse & misuse of these drugs. A significant number of prescriptions are frequently deemed superfluous. Furthermore, antibiotics are read

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Yadav, Shailendra Kumar, Himanshu Dandu, Prashant Gupta, Anuradha Nischal, and Virendra Atam. "Antimicrobial resistance and antimicrobial stewardship program: Need of the hour." Journal of Internal Medicine of India 16, no. 2 (2022): 21–25. http://dx.doi.org/10.4103/upjimi.upjimi_12_24.

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Abstract: Appropriate antibiotic prescribing and stewardship techniques must be developed to support logical therapy and avoid the unintended effects of antimicrobial resistance (AMR). To combat resistance and safeguard global health, this review emphasizes the scope and ramifications of AMR as well as the significance and implications of the AMSP. The worldwide public health is being threatened by AMR. Because of the increased strain on health care, it raises morbidity and mortality and is linked to significant economic expenses. The clinical and financial consequences of multidrug-resistant

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Oloso, Nurudeen O., Ismail A. Odetokun, Ibraheem Ghali-Mohammed, Folorunso O. Fasina, Isaac Olufemi Olatoye, and Victoria O. Adetunji. "Knowledge, Attitudes, and Risk Perception of Broiler Grow-Out Farmers on Antimicrobial Use and Resistance in Oyo State, Nigeria." Antibiotics 11, no. 5 (2022): 567. http://dx.doi.org/10.3390/antibiotics11050567.

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Assessing knowledge, attitudes, and risk perception of Nigerian broiler grow-out farmers (n = 152) to antimicrobial resistance (AMR) with a five sectional purposive-structured-questionnaire: demographics; knowledge; attitudes; risk-perception; and response to regulation of antimicrobial practices. Data were analyzed using descriptive statistics, chi-square test, and binary logistic regression. Respondents’ knowledge score, in total, was lower than average, with all (100%) respondents having the understanding that antibiotics kill/reduce bacteria, most participants (>73%) believing that feed

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Oloso, Nurudeen O., Ismail A. Odetokun, Ibraheem Ghali-Mohammed, Folorunso O. Fasina, Isaac Olufemi Olatoye, and Victoria O. Adetunji. "Knowledge, Attitudes, and Risk Perception of Broiler Grow-Out Farmers on Antimicrobial Use and Resistance in Oyo State, Nigeria." Antibiotics 11, no. 5 (2022): 567. http://dx.doi.org/10.3390/antibiotics11050567.

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Assessing knowledge, attitudes, and risk perception of Nigerian broiler grow-out farmers (n = 152) to antimicrobial resistance (AMR) with a five sectional purposive-structured-questionnaire: demographics; knowledge; attitudes; risk-perception; and response to regulation of antimicrobial practices. Data were analyzed using descriptive statistics, chi-square test, and binary logistic regression. Respondents’ knowledge score, in total, was lower than average, with all (100%) respondents having the understanding that antibiotics kill/reduce bacteria, most participants (>73%) believing that feed

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Varshney, Shruti, Karthika P, Sameena Ahmad, and Saira Mehnaz. "Knowledge, Attitude and Practices Regarding Antimicrobial Resistance among Undergraduate Students." Indian Journal of Community Health 36, no. 4 (2024): 556–64. http://dx.doi.org/10.47203/ijch.2024.v36i04.009.

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Background: Antimicrobial resistance (AMR) poses a significant global health threat, driven by factors such as irrational antibiotic use and limited healthcare infrastructure. Addressing knowledge gaps and promoting responsible antibiotic use among medical professionals is crucial to combat this growing problem. Objectives: This study aimed to assess the knowledge, attitudes, and practices (KAP) regarding antibiotics and antimicrobial resistance among medical students at a medical college in North India. Methods: A cross-sectional study was conducted between October to December 2023, involving

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Najmul, Haque Barbhuiya, Das Deepjyoti, and Adak Asok. "Antimicrobials and antimicrobial resistance: Causes and remedies – A short review." Journal of Indian Chemical Society Vol. 96, Apr 2019 (2019): 441–46. https://doi.org/10.5281/zenodo.5637804.

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Department of Civil Engineering, Indian Institute of Engineering Science and Technology, Shibpur, Howrah-711 103, West Bengal, India <em>E-mail</em>: najmulcib13@gmail.com <em>Manuscript received online 30 January 2019, accepted 14 March 2019</em> The residuals of pharma wastes have been found to be present in wastewater, surface water, aquifers and even in potable water from treatment plants. The antimicrobial resistance (AMR) has been observed to increase and spread, primarily because of misuse and overuse of antibiotics, thereby threatening our public health, global economy and development.

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Tanga, Coch Tanguy Floyde, Patrice Makouloutou-Nzassi, Pierre Philippe Mbehang Nguema, et al. "Antimicrobial Resistance in African Great Apes." Antibiotics 13, no. 12 (2024): 1140. http://dx.doi.org/10.3390/antibiotics13121140.

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Background/Objectives: Antibiotic-resistant bacteria pose a significant global public health threat that demands serious attention. The proliferation of antimicrobial resistance (AMR) is primarily attributed to the overuse of antibiotics in humans, livestock, and the agro-industry. However, it is worth noting that antibiotic-resistant genes (ARGs) can be found in all ecosystems, even in environments where antibiotics have never been utilized. African great apes (AGAs) are our closest living relatives and are known to be susceptible to many of the same pathogens (and other microorganisms) as hu

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Nemr, Nader, Rania M. Kishk, Noha M. Abu Bakr Elsaid, Nageh Louis, Eman Fahmy, and Sally Khattab. "Knowledge, attitude, and practice (KAP) of antimicrobial prescription and its resistance among health care providers in the COVID-19 era: A cross sectional study." PLOS ONE 18, no. 8 (2023): e0289711. http://dx.doi.org/10.1371/journal.pone.0289711.

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Antimicrobial resistance (AMR) is considered as a global health and development threat. During COVID-19 pandemic, there has been an increase in antimicrobial resistance. Health care providers (HCPs) play the main role in facing antibiotic resistance because they have the authority to prescribe antibiotics during clinical practice as well as in promoting patients’ compliance with therapies and avoid self-medication. So, this study will serve as an important source of information in context with Covid19 pandemic in Egypt. The data was collected using a validated standardized self-administered on

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Konova, Natalia, Andrey Petrov, Diana Pendicheva, Yavor Assyov, and Emil Gatchev. "Key features of hospitals antibiotic stewardship software solutions needed for successfully optimizing patient outcomes while fighting antibiotic resistance on a global scale – a shared experience." Pharmacia 71 (August 16, 2024): 1–6. https://doi.org/10.3897/pharmacia.71.e130414.

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Antimicrobial resistance threatens the very core of modern medicine and currently costs the EU more than 11.7 billion euro per year. In 2050 it is projected that 10 million people will die from infections with the so called "superbugs". In the past few decades, no entirely new antibiotic groups are being discovered which makes of crucial importance to preserve the effectiveness of the antibiotics we have today for future generations. Antimicrobial stewardship programs worldwide aim to optimize the use of antimicrobials to improve effectiveness, safety and economic feasibility of antibiotics wh

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Daulaire, Nils, Abhay Bang, Göran Tomson, Joan N. Kalyango, and Otto Cars. "Universal Access to Effective Antibiotics is Essential for Tackling Antibiotic Resistance." Journal of Law, Medicine & Ethics 43, S3 (2015): 17–21. http://dx.doi.org/10.1111/jlme.12269.

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The right to health is enshrined in the constitution of the World Health Organization and numerous other international agreements. Yet today, an estimated 5.7 million people die each year (Table 1) from treatable infectious diseases, most of which are susceptible to existing antimicrobials if they were accessible. These deaths occur predominantly among populations living in poverty in low- and middle-income countries, and they greatly exceed the estimated 700,000 annual deaths worldwide currently attributed to antimicrobial resistance (AMR). Ensuring universal appropriate access to antimicrobi

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Mishra, Sachchida Nand, Shraddha Singh, Mudit Pandey, Ravi Raj, and Shubham. "Antimicrobial Properties of Plant-Derived Compounds against Multidrug-Resistant Bacteria." Journal of Advances in Biology & Biotechnology 28, no. 4 (2025): 588–96. https://doi.org/10.9734/jabb/2025/v28i42218.

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The worldwide epidemic rise in antimicrobial resistance (AMR) is a result of the careless and excessive use of therapeutically useful antibiotics in the veterinary, medicinal, and agricultural sectors. Researchers and stakeholders are becoming increasingly concerned that the environment serves as a reservoir for antimicrobial resistance genes (AMR) and is crucial to the spread of these genes. The use of antimicrobial drugs in healthcare, agriculture, livestock, and the environment, as well as the release of remnants of antibiotics from various residential settings, are some of the causes that

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Sakalauskienė, Giedrė Valdonė, and Aurelija Radzevičienė. "Antimicrobial Resistance: What Lies Beneath This Complex Phenomenon?" Diagnostics 14, no. 20 (2024): 2319. http://dx.doi.org/10.3390/diagnostics14202319.

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Antimicrobial Resistance (AMR) has evolved from a mere concern into a significant global threat, with profound implications for public health, healthcare systems, and the global economy. Since the introduction of antibiotics between 1945 and 1963, their widespread and often indiscriminate use in human medicine, agriculture, and animal husbandry has led to the emergence and rapid spread of antibiotic-resistant genes. Bacteria have developed sophisticated mechanisms to evade the effects of antibiotics, including drug uptake limitation, drug degradation, target modification, efflux pumps, biofilm

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Pandey, Ramendra Pati, Riya Mukherjee, and Chung-Ming Chang. "[Final accepted version, unedited] Antimicrobial resistance surveillance system mapping in different countries." Drug Target Insights 16, no. 1 (2022): 1. http://dx.doi.org/10.33393/dti.2022.2482.

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ObjectivesExcessive use of antibiotics has extensively increased antimicrobial resistance worldwide which is the major public concern among the countries. To control this threat proper monitoring of the antimicrobial usage with the increasing rate of antimicrobial resistance (AMR) is required. Moreover, alternatives for antibiotics are surveyed and are being researched for quick use in the future. Thus, intervention of multisector is highly encouraged for better outcomes. In this research paper, six different European countries are discussed in terms of antimicrobial usage and AMR in the human

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Zhao, Dongqing, Konrad Wojnarowski, Paulina Cholewińska, and Dušan Palić. "Current Trends in Approaches to Prevent and Control Antimicrobial Resistance in Aquatic Veterinary Medicine." Pathogens 14, no. 7 (2025): 681. https://doi.org/10.3390/pathogens14070681.

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The growth of aquaculture production in recent years has revealed multiple challenges, including the rise of antimicrobial resistance (AMR) in aquatic animal production, which is currently attracting significant attention from multiple one-health stakeholders. While antibiotics have played a major role in the treatment of bacterial infections for almost a century, a major consequence of their use is the increase in AMR, including the emergence of AMR in aquaculture. The AMR phenomenon creates a situation where antibiotic use in one system (e.g., aquaculture) may impact another system (e.g., te

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Ashraf, Mohammad Vikas, Shreekar Pant, M. A. Hannan Khan, et al. "Phytochemicals as Antimicrobials: Prospecting Himalayan Medicinal Plants as Source of Alternate Medicine to Combat Antimicrobial Resistance." Pharmaceuticals 16, no. 6 (2023): 881. http://dx.doi.org/10.3390/ph16060881.

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Among all available antimicrobials, antibiotics hold a prime position in the treatment of infectious diseases. However, the emergence of antimicrobial resistance (AMR) has posed a serious threat to the effectiveness of antibiotics, resulting in increased morbidity, mortality, and escalation in healthcare costs causing a global health crisis. The overuse and misuse of antibiotics in global healthcare setups have accelerated the development and spread of AMR, leading to the emergence of multidrug-resistant (MDR) pathogens, which further limits treatment options. This creates a critical need to e

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Sharma, Deeksha, MD Pharmacology, Rpgmc Kangra, and Tanda . "TACKLING ANTIMICROBIAL RESISTANCE: COMPREHENSIVEREVIEW OF MECHANISMS, TRENDS, AND STRATEGIES." International Journal of Advanced Research 12, no. 07 (2024): 910–16. http://dx.doi.org/10.21474/ijar01/19130.

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Background:Antimicrobial resistance (AMR) is a major global issue that leads to more deaths, illnesses, and higher healthcare expenses. This review aims to synthesize the current understanding of AMR, including its mechanisms, prevalence, impact, and strategies to combat it. Objectives: This review gives a complete summary of what we know about AMR, how it develops resistance, and its social and economic effects.. Additionally, it explores current and emerging approaches to combat AMR and antibiotic stewardship programme. Methods: A thorough search of many research papers was done using databa

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Kezia, Gyasi-Darko, Dufie Amofah Akosua, Ugwu Doreen, Narh Apaflo Jehu, and Oware Edward. "Initiatives to promote the responsible use of antibiotics and the development of new antimicrobial agents." World Journal of Advanced Research and Reviews 24, no. 3 (2024): 2187–94. https://doi.org/10.5281/zenodo.15221226.

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Antimicrobial resistance (AMR) is a serious threat to the nation's public health with over 2.8 million antibiotic-resistant infections in the United States annually. The focus of this study is on key initiatives to combat AMR via promoting responsible antibiotic use and antimicrobial development. As a result of wide implementation of antimicrobial stewardship programs (ASPs) in US healthcare settings, antibiotic misuse has been significantly reduced, and clinical outcomes have been improved. Further optimization of antibiotic prescribing practices is achieved by the expansion of ASPs to outpat

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Alamgir, Wasim, and Adnan Haider. "Nanoantibiotics: A Tool Against Antimicrobial Resistance." Life and Science 5, no. 2 (2024): 02. http://dx.doi.org/10.37185/lns.1.1.657.

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Antimicrobial Resistance (AMR), is one of the biggest emerging threats to human health and healthcare systems. Experts are suggesting that the post-antibiotic era, in which microbial infections and minor injuries will again become fatal, is near. A report published by the Antibiotics Resistance Collaborators, in the Lancet,reported that 1.27 million people died due to antibiotic-resistant bacterial infections in 2019.1 Deaths could reach 10 million by 2050 if the problem is not addressed. Antimicrobial resistance arises as a natural adaptation of microorganisms to environmental challenges. One

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N, Singh, Das D, Sherwani N, and Sinha A. "Streptomyces: Sources of Novel Discoveries in Antibiotic Research to Combat Antimicrobial Resistance." Virology & Immunology Journal 9, no. 1 (2025): 1–8. https://doi.org/10.23880/vij-16000356.

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Antimicrobial resistance (AMR) is one of the most serious challenges to global public health this century. The first World Health Organization (WHO) Global report on AMR surveillance, published in April 2014, collected data for the first time from national and international surveillance networks, demonstrating the extent of this phenomenon in many parts of the world as well as the presence of significant gaps in existing surveillance. Given the rising reporting of multi-resistant bacteria and the shortage of newly licensed treatments, researchers have started looking into severe and uncommon c

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Debela, Negeri, and Solome Nekahiwot. "Sepsis, Antimicrobial Resistance, and Alternative Therapies." American Journal of Health Research 12, no. 1 (2024): 8–18. http://dx.doi.org/10.11648/j.ajhr.20241201.12.

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Sepsis, a life-threatening condition caused by the body&apos;s excessive response to an infection, has emerged as a global health menace. Around 20% of all global deaths are attributable to sepsis. Conversely, the presence of antimicrobial resistance (AMR) poses a significant peril to the health system. AMR constitutes an escalating pandemic that we must not disregard, as the absence of effective antibiotics would compromise the treatment of even commonplace bacterial infections. Therefore, the increasing prevalence of AMR further adds complexity to the management and outcomes of individua

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Chrysou, Konstantina, Olympia Zarkotou, Vasiliki Mamali, et al. "32. Impact of a Four-Year Antimicrobial Stewardship Program on Antimicrobial Resistance." Open Forum Infectious Diseases 8, Supplement_1 (2021): S138—S139. http://dx.doi.org/10.1093/ofid/ofab466.234.

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Abstract Background Antimicrobial resistance (AMR) is an increasing threat to public health and antimicrobial consumption is a primary driver of resistance. Many studies have shown that the implementation of an antibiotic stewardship program (ASP) improves prescribing of antibiotics and can reduce AMR. Purpose of the study was to assess the impact of a successful ASP, implemented for four years, on AMR in our 427-bed tertiary general hospital. Methods We monitored pharmacy data for the years 2015 (pre-intervention) and 2016-2019 (post-intervention) for antibiotic consumption (DDD/100 bed-days)

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Shang, Zifang, Siew Yin Chan, Qing Song, Peng Li, and Wei Huang. "The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance." Research 2020 (September 28, 2020): 1–32. http://dx.doi.org/10.34133/2020/2016201.

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The emerging antimicrobial resistance (AMR) poses serious threats to the global public health. Conventional antibiotics have been eclipsed in combating with drug-resistant bacteria. Moreover, the developing and deploying of novel antimicrobial drugs have trudged, as few new antibiotics are being developed over time and even fewer of them can hit the market. Alternative therapeutic strategies to resolve the AMR crisis are urgently required. Pathogen-oriented therapy (POT) springs up as a promising approach in circumventing antibiotic resistance. The tactic underling POT is applying antibacteria

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Teague, Elisma, Selente Bezuidenhout, Johanna C. Meyer, Brian Godman, and Deirdré Engler. "Knowledge and Perceptions of Final-Year Nursing Students Regarding Antimicrobials, Antimicrobial Resistance, and Antimicrobial Stewardship in South Africa: Findings and Implications to Reduce Resistance." Antibiotics 12, no. 12 (2023): 1742. http://dx.doi.org/10.3390/antibiotics12121742.

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Antimicrobial resistance (AMR) is being increasingly seen as the next pandemic due to high morbidity and mortality rates, with Sub-Saharan Africa currently having the highest mortality rates driven by high rates of inappropriate prescribing in ambulatory care. In South Africa, nurses typically provide a range of services, including prescribing, in public ambulatory care clinics. However, little is currently known about the perception of final-year nursing students regarding antibiotic use, AMR, and antimicrobial stewardship (AMS). Consequently, we sought to address this important evidence gap.

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Shahpawee, Nurul Shaheera, Li Ling Chaw, Siti Hanna Muharram, Hui Poh Goh, Zahid Hussain, and Long Chiau Ming. "University Students’ Antibiotic Use and Knowledge of Antimicrobial Resistance: What Are the Common Myths?" Antibiotics 9, no. 6 (2020): 349. http://dx.doi.org/10.3390/antibiotics9060349.

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We aimed to assess antibiotic usage and knowledge regarding antibiotics and antimicrobial resistance (AMR) among undergraduate students of the Universiti Brunei Darussalam (UBD), public university located in Brunei Darussalam. A cross-sectional study was performed using a self-administered questionnaire. The questionnaire was adapted from the World Health Organization’s (WHO) “Antibiotic resistance: Multi-country public awareness” survey distributed online. Students at the UBD were invited to participate in the online survey through internal email. The questionnaire consisted of five sections:

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Lajqi Berisha, Njomza, Ana Poceva Panovska, and Zehra Hajrulai-Musliu. "Antibiotic Resistance and Aquatic Systems: Importance in Public Health." Water 16, no. 17 (2024): 2362. http://dx.doi.org/10.3390/w16172362.

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This review focuses on the crucial role of aquatic ecosystems in preserving biodiversity and the biosphere, as well as the connection between antimicrobial resistance (AMR) and these ecosystems. It provides an in-depth analysis of the link between ecological well-being and public health, helping readers understand this complex subject. Aquatic ecosystems are essential for maintaining biodiversity and ecological balance. Additionally, they act as primary reservoirs and pathways for the spread of antimicrobial resistance (AMR). These ecosystems risk antibiotic contamination through various sourc

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Akhiruzzaman. "Antimicrobial Resistance (AMR) and Newer Approaches to Combat against It." Journal of Diabetic Association Medical College, Faridpur 9, Number 1 (2025): 24–28. https://doi.org/10.70357/jdamc.2025.v0901.06.

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Antimicrobial resistance is a global health crisis and a threat to human and animal health, environmental safety, andeconomic stability. Indiscriminate use, overuse or misuse of antibiotics in human body, agriculture product and veterinarypractices have boosted this condition and further worsened by the COVID-19 pandemic, where increase in irrationaluse of antibiotic was noticed. The main sufferer of this condition is low- and middle-income countries due to poor healthinfrastructure, poor regulation, and frequent practices of self-medication, particularly evident in regions such as SouthAsia.T

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Nwafia, I., S. Nwafia, P. Ibeh, et al. "Knowledge of antibiotic resistance and habits of antibiotic use among medical students of University of Nigeria Enugu: a descriptive cross-sectional survey." African Journal of Clinical and Experimental Microbiology 25, no. 3 (2024): 342–49. https://doi.org/10.4314/ajcem.v25i3.11.

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Background: The adverse effects of antimicrobial resistance (AMR) are manifesting worldwide. A major contributing factor to AMR is the inappropriate use of antimicrobials in humans and animals. It is imperative to raise awareness among medical students of the current public health challenges of AMR and make them antibiotic guardians because they are the future medical doctors. This survey was designed to assess the knowledge of AMR and habits of antimicrobial use (AMU) among medical students as a means to guide them in their future practice. Methodology: This descriptive cross-sectional survey

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Malagón-Rojas, Jeadran N., Eliana L. Parra Barrera, and Luisa Lagos. "From environment to clinic: the role of pesticides in antimicrobial resistance." Revista Panamericana de Salud Pública 44 (September 23, 2020): 1. http://dx.doi.org/10.26633/rpsp.2020.44.

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Antimicrobial resistance (AMR) in pathogens has been associated mainly with excessive use of antibiotics. Most studies of resistance have focused on clinical pathogens; however, microorganisms are exposed to numerous anthropogenic substances. Few studies have sought to determine the effects of chemical substances on microorganisms. Exposure to these substances may contribute to increased rates of AMR. Understanding microorganism communities in natural environments and AMR mechanisms under the effects of anthropogenic substances, such as pesticides, is important to addressing the current crisis

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Hamada, Yukihiro, Fumiya Ebihara, and Ken Kikuchi. "A Strategy for Hospital Pharmacists to Control Antimicrobial Resistance (AMR) in Japan." Antibiotics 10, no. 11 (2021): 1284. http://dx.doi.org/10.3390/antibiotics10111284.

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In Japan, there is concern regarding the relation between the inappropriate use of antibiotics and antibiotic resistance (AMR). Increased bacterial resistance is due in part to the inappropriate use of antimicrobial agents. The support of the pharmacist becomes important, and there is growing interest in antimicrobial stewardship to promote the appropriate and safe use of antimicrobials needed for the optimal selection of drugs, doses, durations of therapy, therapeutic drug monitoring (TDM), and implementations of cost containment strategies in Japan. Pharmacists should strive to disseminate t

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Ejike Innocent Nwankwo, Ebube Victor Emeihe, Mojeed Dayo Ajegbile, Janet Aderonke Olaboye, and Chukwudi Cosmos Maha. "Innovative drug delivery methods for combating antimicrobial resistance." International Medical Science Research Journal 4, no. 8 (2024): 834–58. http://dx.doi.org/10.51594/imsrj.v4i8.1454.

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Antimicrobial resistance (AMR) poses a significant threat to global health, complicating the treatment of infectious diseases and leading to increased morbidity and mortality. Innovative drug delivery methods are emerging as critical strategies to combat AMR by enhancing the efficacy of existing antibiotics and facilitating the development of new therapeutic approaches. This paper explores the role of novel drug delivery systems in addressing AMR challenges. One of the primary approaches is the development of targeted drug delivery systems that improve the precision of antibiotic therapy. Nano

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