Academic literature on the topic 'Artificial chromosomes'

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Journal articles on the topic "Artificial chromosomes"

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Csonka, E., I. Cserpan, K. Fodor, et al. "Novel generation of human satellite DNA-based artificial chromosomes in mammalian cells." Journal of Cell Science 113, no. 18 (2000): 3207–16. http://dx.doi.org/10.1242/jcs.113.18.3207.

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An in vivo approach has been developed for generation of artificial chromosomes, based on the induction of intrinsic, large-scale amplification mechanisms of mammalian cells. Here, we describe the successful generation of prototype human satellite DNA-based artificial chromosomes via amplification-dependent de novo chromosome formations induced by integration of exogenous DNA sequences into the centromeric/rDNA regions of human acrocentric chromosomes. Subclones with mitotically stable de novo chromosomes were established, which allowed the initial characterization and purification of these ar
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Ross, L. O., D. Treco, A. Nicolas, J. W. Szostak, and D. Dawson. "Meiotic recombination on artificial chromosomes in yeast." Genetics 131, no. 3 (1992): 541–50. http://dx.doi.org/10.1093/genetics/131.3.541.

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Abstract We have examined the meiotic recombination characteristics of artificial chromosomes in Saccharomyces cerevisiae. Our experiments were carried out using minichromosome derivatives of yeast chromosome III and yeast artificial chromosomes composed primarily of bacteriophage lambda DNA. Tetrad analysis revealed that the artificial chromosomes exhibit very low levels of meiotic recombination. However, when a 12.5-kbp fragment from yeast chromosome VIII was inserted into the right arm of the artificial chromosome, recombination within that arm mimicked the recombination characteristics of
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Rudd, M. Katharine, Robert W. Mays, Stuart Schwartz, and Huntington F. Willard. "Human Artificial Chromosomes with Alpha Satellite-Based De Novo Centromeres Show Increased Frequency of Nondisjunction and Anaphase Lag." Molecular and Cellular Biology 23, no. 21 (2003): 7689–97. http://dx.doi.org/10.1128/mcb.23.21.7689-7697.2003.

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ABSTRACT Human artificial chromosomes have been used to model requirements for human chromosome segregation and to explore the nature of sequences competent for centromere function. Normal human centromeres require specialized chromatin that consists of alpha satellite DNA complexed with epigenetically modified histones and centromere-specific proteins. While several types of alpha satellite DNA have been used to assemble de novo centromeres in artificial chromosome assays, the extent to which they fully recapitulate normal centromere function has not been explored. Here, we have used two kind
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Singchat, Worapong, Thitipong Panthum, Syed Farhan Ahmad, et al. "Remnant of Unrelated Amniote Sex Chromosomal Linkage Sharing on the Same Chromosome in House Gecko Lizards, Providing a Better Understanding of the Ancestral Super-Sex Chromosome." Cells 10, no. 11 (2021): 2969. http://dx.doi.org/10.3390/cells10112969.

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Comparative chromosome maps investigating sex chromosomal linkage groups in amniotes and microsatellite repeat motifs of a male house gecko lizard (Hemidactylus frenatus, HFR) and a flat-tailed house gecko lizard (H. platyurus, HPL) of unknown sex were examined using 75 bacterial artificial chromosomes (BACs) from chicken and zebra finch genomes. No massive accumulations of microsatellite repeat motifs were found in either of the gecko lizards, but 10 out of 13 BACs mapped on HPL chromosomes were associated with other amniote sex chromosomes. Hybridization of the same BACs onto multiple differ
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Huxley, Clare. "Mammalian artificial chromosomes and chromosome transgenic." Trends in Genetics 13, no. 9 (1997): 345–47. http://dx.doi.org/10.1016/s0168-9525(97)01256-0.

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Monaco, Z. Larin, and D. Moralli. "Progress in artificial chromosome technology." Biochemical Society Transactions 34, no. 2 (2006): 324–27. http://dx.doi.org/10.1042/bst0340324.

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Artificial chromosomes is an exciting technology which has developed rapidly since the late 1990s. HACs (human artificial chromosomes) are autonomous molecules that can function and segregate as normal chromosomes in human cells. The advantages of an artificial-chromosome-based system are 2-fold. First, HACs are an excellent research tool for investigating the requirements for normal chromosome structure and function during the cell cycle. They are important in defining the sequence requirements of functional chromosomes, and investigating the organization and composition of the chromatin. Sec
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Murray, Andrew W., and Jack W. Szostak. "Artificial Chromosomes." Scientific American 257, no. 5 (1987): 62–68. http://dx.doi.org/10.1038/scientificamerican1187-62.

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Fachinetti, Daniele, Hiroshi Masumoto, and Natalay Kouprina. "Artificial chromosomes." Experimental Cell Research 396, no. 1 (2020): 112302. http://dx.doi.org/10.1016/j.yexcr.2020.112302.

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Serafim, Lazaro, Jarbson Henrique Silva, Sibelle Dias, et al. "“End-to-End Chromosome Fusion” as the Main Driver of Descending Dysploidy in Vigna lasiocarpa (Mart. ex Benth.) Verdc. (Leguminosae Juss.)." Plants 14, no. 12 (2025): 1872. https://doi.org/10.3390/plants14121872.

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The genus Vigna Savi (Leguminosae Juss.) comprises approximately 150 species, classified into five subgenera, most of which exhibit a diploid chromosome number of 2n = 22. However, the wild species Vigna lasiocarpa (Benth) Verdc. (V. subg. Lasiospron) is notable for its dysploid chromosome number of 2n = 20. This study aimed to elucidate the chromosomal events involved in the karyotype evolution of V. lasiocarpa (Vla). We used oligopainting probes from chromosomes 1, 2, 3, and 5 of Phaseolus vulgaris L. and two barcode probes from the genome of V. unguiculata (L.) Walp. Additionally, bacterial
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Perez, Carl, Gary de Jong, Jan Drayer, and Gyula Hadlaczky. "Satellite DNA-based artificial chromosomes – chromosomal vectors." Trends in Biotechnology 18, no. 10 (2000): 402–3. http://dx.doi.org/10.1016/s0167-7799(00)01487-6.

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Dissertations / Theses on the topic "Artificial chromosomes"

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Morroll, Shaun Michael. "Mapping of yeast artificial chromosomes from Arabidopsis chromosome 5." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308922.

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Heller, Raoul. "Engineering of human artificial mini-chromosomes." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360317.

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Mandegar, Mohammad Ali. "Analysis of artificial chromosomes in human embryonic stem cells." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:81d118c3-dd01-40e4-9fea-2c335d9f3101.

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The development of safe and efficient gene delivery systems in pluripotent human embryonic stem cells (hESc) is essential to realising their full potential for basic and clinical research. The purpose of this study was to develop an efficient, non-integrating gene expression system in pluripotent hESc using human artificial chromosomes (HAC). Similar to endogenous chromosomes, HAC are capable of gene expression, replication and segregation during cell division. Unlike retroviral-mediated gene delivery vectors, HAC do not integrate into the host genome and can encompass large genomic regions fo
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Mann, Kathryn Louise. "Investigation of possible cloning hosts for mammalian artificial chromosomes." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393888.

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Meaney, Paul James. "Mapping the Plasmodium falciparum genome with yeast artificial chromosomes." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/12640.

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Yeast Artificial Chromosome cloning vectors, with their capacity to maintain up to 1 Mb of cloned DNA in a stable form, have proved extremely useful in mapping the genomes of higher eukaryotes. These vectors possess features which can circumvent some of the problems associated with classical molecular manipulation in <I>Plasmodium falciparum. </I>The research presented in this thesis is aimed at contributing to genome mapping in <I>P. falciparum. </I>The primary objective is the construction of a complete, detailed YAC- based physical map of chromosome 6, with a resolution of 10 Kb. To accompl
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Chan, David Yiu Leung. "Analysis of artificial chromosomes and factors affecting stability in murine and human cultured and embryonic stem cells." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568074.

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Human Artificial Chromosomes (HAC) are fascinating extrachromosomal molecules that stay independently from the host genome and are capable of segregating as efficiently as endogenous chromosomes. It has been proven that HAC are potential tools for both basic chromosome behavioural research and agents for gene therapy purposes. My DPhil project is divided into two main themes. The first theme was to develop a novel artificial chromosome in mouse embryonic stem cells. The second theme was to understand the factors affecting chromosome stability which may also affect the efficiency of artificial
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Alazami, Anas Muhammad. "The establishment and validation of artificial chromosomes in mammalian cells." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400456.

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Tonga, Lavon Paongo Hutt-Fletcher Lindsey M. "Development of an Akata-based bacterial artificial chromosome." Diss., UMK access, 2006.

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Thesis (Ph. D.)--School of Biological Sciences. University of Missouri--Kansas City, 2006.<br>"A dissertation in molecular biology and biochemistry and cell biology and biophysics." Advisor: Lindsey M. Hutt-Fletcher. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Nov. 9, 2007. Includes bibliographical references (leaves 89-103). Online version of the print edition.
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Howe, Steven James. "orip-EBNA-1 artificial chromosomes as expression vectors for gene therapy." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271147.

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Francis, Michael J. "Physical mapping around the SMA gene using yeast artificial chromosomes (YACs)." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259879.

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Books on the topic "Artificial chromosomes"

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Shaying, Zhao, and Stodolsky Marvin, eds. Bacterial artificial chromosomes. Humana Press, 2004.

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Sgaramella, Vittorio, and Sandro Eridani. Mammalian Artificial Chromosomes. Humana Press, 2003. http://dx.doi.org/10.1385/1592594344.

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Zhao, Shaying, and Marvin Stodolsky. Bacterial Artificial Chromosomes. Humana Press, 2004. http://dx.doi.org/10.1385/1592597521.

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Zhao, Shaying, and Marvin Stodolsky. Bacterial Artificial Chromosomes. Humana Press, 2004. http://dx.doi.org/10.1385/159259753x.

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Narayanan, Kumaran, ed. Bacterial Artificial Chromosomes. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-1652-8.

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James, Louise Anne. Physical mapping on human chromosome 3 using yeast artificial chromosomes. University of Manchester, 1994.

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V, Sgaramella, and Eridani Sandro, eds. Mammalian artificial chromosomes: Methods and protocols. Humana Press, 2004.

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Tracey, S. M. The effects of yeast artificial chromosomes of the yeast genome. UMIST, 1995.

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Heale, S. M. Factors effecting the utility of yeast artificial chromosomes as cloning vectors. UMIST, 1993.

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Meyer, Knut. Positional cloning of the ABI1 locus of arabidopsis thaliana using yeast artificial chromosomes. Eidgenössische Technische Hochschule Zürich, 1994.

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Book chapters on the topic "Artificial chromosomes"

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Clark, M. S., and W. J. Wall. "Artificial manipulation of genomes." In Chromosomes. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0073-8_10.

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Julin, Douglas. "Artificial Chromosomes." In Molecular Life Sciences. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-6436-5_91-3.

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Julin, Douglas A. "Artificial Chromosomes." In Molecular Life Sciences. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4614-1531-2_91.

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Flannery, Angela, and Rakesh Anand. "Yeast Artificial Chromosomes." In Springer Protocols Handbooks. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-59259-642-3_24.

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Cooke, Howard J. "Artificial Chromosomes — Past, Present and Future." In Chromosomes Today. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-94-017-1033-6_18.

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Gooch, Jan W. "Yeast Artificial Chromosomes (YACs)." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_15129.

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Zeidler, Michael G., and Thomas L. Saunders. "Transgene Recombineering in Bacterial Artificial Chromosomes." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8831-0_3.

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Dewar, Ken, Bruce W. Birren, and Hadi Abderrahim. "Bacterial Artificial Chromosomes and Animal Transgenesis." In Transgenic Animals. CRC Press, 2022. http://dx.doi.org/10.1201/9781003211099-56.

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Tobler, Kurt, and Cornel Fraefel. "Infectious Delivery of Alphaherpesvirus Bacterial Artificial Chromosomes." In Methods in Molecular Biology. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1652-8_10.

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Alonso, Jose M., and Anna N. Stepanova. "Arabidopsis Transformation with Large Bacterial Artificial Chromosomes." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-580-4_15.

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Conference papers on the topic "Artificial chromosomes"

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Zhang, XinXu, HaoXi Zhang, and Edward Szczerbicki. "Interpretable Chromosomal Abnormality Recognition." In 2024 5th International Conference on Computer, Big Data and Artificial Intelligence (ICCBD+AI). IEEE, 2024. https://doi.org/10.1109/iccbd-ai65562.2024.00090.

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Peng, Yifeng, Haoxi Zhang, Fei Li, and Edward Szczerbicki. "Chromosome Straightening via Disentangled Representations: Exploring Semantic Trajectories in GAN’s Latent Space." In 2024 5th International Conference on Computer, Big Data and Artificial Intelligence (ICCBD+AI). IEEE, 2024. https://doi.org/10.1109/iccbd-ai65562.2024.00049.

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Chen, Ran, Haoxi Zhang, and Edward Szczerbickid. "A Hybrid ResNet and ViT Model for Domain Generalization in Chromosome Classification." In 2024 5th International Conference on Computer, Big Data and Artificial Intelligence (ICCBD+AI). IEEE, 2024. https://doi.org/10.1109/iccbd-ai65562.2024.00085.

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Balasubramani, A., and Anitha D. "Intelligent Chromosome Karyotyping: A Cutting-Edge Automated System for Accurate Detection and Analysis." In 2025 2nd International Conference on Research Methodologies in Knowledge Management, Artificial Intelligence and Telecommunication Engineering (RMKMATE). IEEE, 2025. https://doi.org/10.1109/rmkmate64874.2025.11042504.

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Saranya, S., and S. Lakshmi. "Classification of Chromosomes to Diagnose Chromosomal Abnormalities using CNN." In 2023 International Conference on Artificial Intelligence and Knowledge Discovery in Concurrent Engineering (ICECONF). IEEE, 2023. http://dx.doi.org/10.1109/iceconf57129.2023.10083710.

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Pliszka, Zbigniew, and Olgierd Unold. "Some Remarks on Dynamics of Binary Chromosomes Population." In European Conference on Artificial Life 2013. MIT Press, 2013. http://dx.doi.org/10.7551/978-0-262-31709-2-ch094.

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Pliszka, Zbigniew, and Olgierd Unold. "Some Remarks on Dynamics of Binary Chromosomes Population." In European Conference on Artificial Life 2013. MIT Press, 2013. http://dx.doi.org/10.1162/978-0-262-31709-2-ch094.

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Pei-Chann Chang, Wei-Hsiu Huang, Julie Yu-Chih Liu, Cycer Chen, and Chang-Jung Ting. "Dynamic diversity control by injecting artificial chromosomes for solving TSP problems." In 2008 IEEE Congress on Evolutionary Computation (CEC). IEEE, 2008. http://dx.doi.org/10.1109/cec.2008.4630849.

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Chang, Pei-Chann, Shih-Shin Chen, Qiong-Hui Ko, and Chin-Yuan Fan. "A Genetic Algorithm with Injecting Artificial Chromosomes for Single Machine Scheduling Problems." In 2007 IEEE Symposium on Computational Intelligence in Scheduling. IEEE, 2007. http://dx.doi.org/10.1109/scis.2007.367662.

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Ackovska, Nevena, Liljana Bozinovska, and Stevo Bozinovski. "Artificial chromosomes as genetic disks: A systems software metaphor for genetic engineering." In SOUTHEASTCON 2010. IEEE, 2010. http://dx.doi.org/10.1109/secon.2010.5453861.

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Reports on the topic "Artificial chromosomes"

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Antonarakis, S. E. Human chromosome 21: Linkage mapping and cloning in yeast artificial chromosomes. Office of Scientific and Technical Information (OSTI), 1991. http://dx.doi.org/10.2172/6278130.

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Weier, Heinz-Ulrich G., Karin M. Greulich-Bode, Jenny Wu, and Thomas Duell. Delineating Rearrangements in Single Yeast Artificial Chromosomes by Quantitative DNA Fiber Mapping. Office of Scientific and Technical Information (OSTI), 2009. http://dx.doi.org/10.2172/982923.

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Jean-Michael H. Vos. Final report. Human artificial episomal chromosome (HAEC) for building large genomic libraries. Office of Scientific and Technical Information (OSTI), 1999. http://dx.doi.org/10.2172/764441.

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Dubcovsky, Jorge, Tzion Fahima, and Ann Blechl. Positional cloning of a gene responsible for high grain protein content in tetraploid wheat. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7695875.bard.

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High Grain Protein Content (GPC) is a desirable trait in breadmaking and pasta wheat varieties because of its positive effects on quality and nutritional value. However, selection for GPC is limited by our poor understanding of the genes involved in the accumulation of protein in the grain. The long-term goal of this project is to provide a better understanding of the genes controlling GPC in wheat. The specific objectives of this project were: a) to develop a high-density genetic map of the GPC gene in tetraploid wheat, b) to construct a T. turgidum Bacterial Artificial Chromosome (BAC) libra
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Dubcovsky, Jorge, Tzion Fahima, Ann Blechl, and Phillip San Miguel. Validation of a candidate gene for increased grain protein content in wheat. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7695857.bard.

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High Grain Protein Content (GPC) of wheat is important for improved nutritional value and industrial quality. However, selection for this trait is limited by our poor understanding of the genes involved in the accumulation of protein in the grain. A gene with a large effect on GPC was detected on the short arm of chromosome 6B in a Triticum turgidum ssp. dicoccoides accession from Israel (DIC, hereafter). During the previous BARD project we constructed a half-million clones Bacterial Artificial Chromosome (BAC) library of tetraploid wheat including the high GPC allele from DIC and mapped the G
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Tel-Zur, Neomi, and Jeffrey J. Doyle. Role of Polyploidy in Vine Cacti Speciation and Crop Domestication. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7697110.bard.

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1. Abstract: Over the past 25 years, vine cacti of the genera Hylocereus and Selenicereus have been introduced into Israel and southern California as new exotic fruit crops. The importance of these crops lies in their high water use efficiency and horticultural potential as exotic fruit crops. Our collaboration focused on the cytological, molecular and evolutionary aspects of vine cacti polyploidization to confront the agricultural challenge of genetic improvement, ultimately to improve success of vine cacti as commercial fruit crop plants. More specifically, we worked on the: 1- Identificatio
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