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1

Bañuls, Anne-Laure, Thi Van Ahn Nguyen, Quang Huy Nguyen, Thi Ngoc Anh Nguyen, Hoang Huy Tran, and Sylvain Godreuil. Antimicrobial resistance: the 70-year arms race between humans and bacteria. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789833.003.0006.

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Antimicrobial resistance started to become a human health issue in the 1940s, following the discovery of the first antibiotics. The golden age of antibiotics (the 1950s through 1970s) marked the beginning of the arms race between humans and bacteria. Antimicrobial resistance is now among the greatest threats to human health; occurring in every region of the world and with the potential to affect anyone, anywhere. We describe the main mechanisms of antimicrobial resistance, as well as how the bacteria evolve into “superbugs.” We detail the role of human activities on the emergence and spread of
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2

Amyes, Sebastian G. B. Bacteria: A Very Short Introduction. 2nd ed. Oxford University Press, 2022. http://dx.doi.org/10.1093/actrade/9780192895240.001.0001.

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Bacteria: A Very Short Introduction explores the nature of bacteria, which are the most abundant form of life on the planet. The first organisms to evolve, they include forms that can survive the toughest environments, from deep rocks to frozen wastes. No other organisms are as adaptable. We are most familiar with them as agents of disease, but benign bacteria are critical to ecosystems, as well as to human health. Bacteria play a significant role in the environment and in disease. We cannot ignore the growing resistance of bacteria to antibiotics.
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3

Iversen, Les. 3. Drugs as medicines. Oxford University Press, 2016. http://dx.doi.org/10.1093/actrade/9780198745792.003.0003.

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‘Drugs as medicines’ highlights the principles behind the successful use of medicines to cure or ameliorate the symptoms of many illnesses. These range from infectious diseases, such as bacterial and viral infections; innate conditions, such as mental illness or autoimmune disorders; or those caused by lifestyle, such as coronary heart disease. Despite successes, problems still remain. Many bacteria and viruses are rapidly evolving resistance to drug strategies. Also, those in the developing world, who are most at risk from infection, often benefit least from drugs due to prohibitive costs and
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4

Soulsby, Lord. Antimicrobial resistance: animal use of antibiotics. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0005.

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The evolution of resistance to microbes is one of the most significant problems in modern medicine, posing serious threats to human and animal health. The early work on the use of antibiotics to bacterial infections gave much hope that infectious diseases were no longer a problem, especially in the human field. However, as their use, indeed over use, progressed, resistance (both mono-resistance and multi-resistance), which was often transferable between different strains and species of bacteria, emerged. In addition, the situation is increasingly complex, as various mechanisms of resistance, i
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5

Gardea, Alfonso A. Freeze damage of Pinot Noir (Vitis vinifera L.) as affected by bud development, INA-bacteria, and a bacterial inhibitor. 1987.

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6

Walton, Katherine E., and Sally Ager. Antimicrobial agents. Edited by Rob Pickard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0002.

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Antimicrobial resistance is a growing problem, which can be exacerbated by inappropriate use of antimicrobial agents. An understanding of the judicious use of antimicrobial agents, also known as antimicrobial stewardship, is therefore of fundamental importance to safe clinical practice. Patient factors should also be considered, including age, clinical status, special factors such as pregnancy or immunosuppression, co-morbidities, allergies, medication which may result in potential drug interactions, previous microbiology results, and antimicrobial treatment history. Important antimicrobial ch
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7

Bacterial Enzymes As Targets for Drug Discovery: Meeting the Challenges of Antibiotic Resistance. Elsevier Science & Technology, 2024.

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8

Bacterial Enzymes As Targets for Drug Discovery: Meeting the Challenges of Antibiotic Resistance. Elsevier Science & Technology Books, 2024.

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9

Wilson, Mary E. Antibiotics. Oxford University Press, 2019. http://dx.doi.org/10.1093/wentk/9780190663414.001.0001.

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A STIRRING EXAMINATION OF A LOOMING CRISIS Virtually everyone has taken antibiotics. They can be lifesavers -- or they can be useless. But what are they? How are they used? And what happens as the effectiveness of antibiotics begins to decline? Antibiotics: What Everyone Needs to Know® examines the personal and societal implications of our planet's most important -- and arguably most overused -- medications. In a question-and-answer format, it unpacks the most complicated aspects of this issue, including: · How antibiotics are used (and overused) in humans, plants, and livestock · The conseque
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10

Wilson, A. P. R., and Preet Panesar. Antimicrobial drugs in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0053.

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The pharmacokinetics of antimicrobials are altered in critically-ill patients, particularly in the presence of renal or hepatic failure. Maintaining a choice or diversity of antibiotics is important due to the emergence of resistance. Antibiotic use should also be kept to the minimum and local protocols need to be established. For community-acquired infection, co-amoxiclav or a parenteral cephalosporin can be used, while for hospital-acquired infection, piperacillin/tazobactam, ciprofloxacin, or ceftazidime are recommended. For suspected vascular catheter infection or methicillin-resistant Sta
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11

Hansoti, Bhakti. Pulmonary Tuberculosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0028.

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Mycobacterium tuberculosis (TB) is most commonly known for its manifestations in the lungs; symptoms include fever and chest pain (retrosternal pain and/or dull intracapsular pain). In the reactivation stage of TB, typical symptoms may include cough, weight loss, fatigue, fever, night sweats, chest pain, dyspnea, and/or hemoptysis. Symptoms may remain undiagnosed for several years. Poverty, HIV, and drug resistance are major contributors to the resurging global TB epidemic. Two kinds of tests are used to detect TB: the tuberculin skin test or a TB blood test. These tests only tell you if a per
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12

Dawson, Susan. Other bacterial diseasesStaphylococcal zoonoses. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0026.

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Staphylococcal species are common commensals of the skin and mucous membranes of humans and animals but only in very recent years has zoonotic infections been recognised. They can also be associated with infection and disease, especially coagulase positive organisms. Staphylococcus aureus is relatively frequently carried by humans in the nasal passages and is a cause of infections in people including bacteraemias in hospitalised patients. More recently some strains of Staphylococcus aureus have acquired a resistance gene (mecA) which renders them resistant to meticillin (meticillin-resistant S
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13

Nadel, Simon, and Johnny Canlas. Management of meningitis and encephalitis in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0241.

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Management of CNS infections requires specific antimicrobial agents, as well as specific supportive treatment targeted at reducing raised intracranial pressure and other life-threatening complications. It is important that the need for management in an intensive care setting is considered early in the illness. Antibiotic resistance amongst the most common organisms causing bacterial meningitis is becoming more common and antibiotic therapy should be adjusted accordingly. Anti-inflammatory treatment such as steroids should be started as soon as possible in patients with proven acute bacterial m
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14

Temesgen, Zelalem, ed. Mayo Clinic Infectious Diseases Board Review. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199827626.001.0001.

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While infections have always played an important role in the history of mankind, advances in science and technology as well as rapid globalization have resulted in an unprecedented wave of new and old infections thrust into the limelight. The recent pandemic of H1N1 influenza virus infection demonstrates the recurrent theme of emerging and reemerging pathogens that continue to impact public health and patient care areas. Drug resistance among various organisms (not limited to bacteria) has unfortunately become the expectation and, not infrequently, we have been left with few or no efficacious
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15

Gibreel, Amera. Characterization of Resistance to Quinolones, Sulfonamide and Trimethoprim in Campylabacter Jejuni As Well As to Macrolides in the Related Bacterium, (Comprehensive ... from the Faculty of Pharmacy, 202). Uppsala Universitet, 1999.

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16

Gertz, Alida. Tularemia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0067.

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Tularemia, caused by the gram-negative coccobacillus Francisella tularensis, is an extremely infectious bacterial zoonosis. Symptoms depend on site of exposure; they can be nonspecific and may include fever, lymphadenopathy, ulcer or papule, and nausea/vomiting. Natural transmission occurs via small mammals, such as rabbits, or arthropod bites. IV or IM antibiotics are preferred over oral forms. Supportive care is also critical; some patients may require respiratory support. If used as a biological weapon, aerosolized F. tularensis would be the most likely route of transmission. Clinical sympt
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17

Threlfall, E. J., J. Wain, and C. Lane. Salmonellosis. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0030.

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Salmonellosis remains the second most common form of bacterial food-poisoning in the UK and in most of the developed economies. Although the number of isolations per annum has declined since 2000, over 10,000 laboratory-confirmed cases are recognised each year in England and Wales, and over 150,000 in Europe. Most of infections are associated with contaminated food, particularly of poultry origin, but also may originate from cattle and pigs, and to a lesser extent, sheep. The most common serovars from cases of human infection is Enteritidis, followed by Typhimurium. Contact with pets, particul
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18

Paterson, David L., and Yoshiro Hayashi. Antimicrobial selection policies in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0286.

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Antibiotic selection is a crucial drug choice in critically-ill patients. Optimization of empiric antibiotic choice can be gained by knowledge of the site of infection and the probable causative organisms at that site. This should be linked with knowledge of the local epidemiology of antibiotic resistance in the actual intensive care unit housing the patient. Initial empiric antimicrobial choice may need to be broad in order to cover potential antibiotic-resistant pathogens. However, it is important to be prudent in antibiotic strategy since the selection of multiple-resistant organisms by exc
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19

Thomson, Jennifer. Food for Africa: The life and work of a scientist in GM crops. UCT Press, 2022. http://dx.doi.org/10.15641/1-7758-2048-2.

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Jennifer Thomson is one of the world’s leading advisors on genetically modified crops. In Food for Africa she traces, through anecdote and science, her career and the development of this area of research — from the dawn of genetic engineering in the USA in 1974, through the early stages of its testing in Europe and regulation in South Africa, to the latest developments in South Africa, where an updated Bioeconomy Strategy was approved in early 2013. As a young scientist she chose to study bacterial genetics, negotiating her way in a very male-dominated arena. It led to her path-breaking involv
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