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Journal articles on the topic 'As-Resistance Bacteria'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Nazarov, Pavel, Marina Kuznetsova, and Marina Karakozova. "Multidrug resistance pumps as a keystone of bacterial resistance." Vestnik Moskovskogo universiteta. Seria 16. Biologia 77, no. 4 (2023): 215–23. http://dx.doi.org/10.55959/msu0137-0952-16-2022-77-4-215-223.

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Antibiotic resistance is a global problem of modern medicine. A harbinger of the onset of the post-antibiotic era is the complexity and high cost of developing new antibiotics, as well as their ineffi ciency due to the rapidly developing resistance of bacteria. The cornerstone of bacterial protection against antibiotics are multidrug resistance pumps (MDR), which are involved in the formation of resistance to xenobiotics, the export of toxins, the maintenance of cellular homeostasis, the formation of biofilms and persistent cells. MDR pumps are the basis for the nonspecific protection of bacte

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Dawan, Jirapat, and Juhee Ahn. "Bacterial Stress Responses as Potential Targets in Overcoming Antibiotic Resistance." Microorganisms 10, no. 7 (2022): 1385. http://dx.doi.org/10.3390/microorganisms10071385.

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Bacteria can be adapted to adverse and detrimental conditions that induce general and specific responses to DNA damage as well as acid, heat, cold, starvation, oxidative, envelope, and osmotic stresses. The stress-triggered regulatory systems are involved in bacterial survival processes, such as adaptation, physiological changes, virulence potential, and antibiotic resistance. Antibiotic susceptibility to several antibiotics is reduced due to the activation of stress responses in cellular physiology by the stimulation of resistance mechanisms, the promotion of a resistant lifestyle (biofilm or

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Zhivich, Alexander. "Fighting bacterial resistance: approaches, challenges, and opportunities in the search for new antibiotics. Part 1. Antibiotics used in clinical practice: mechanisms of action and the development of bacterial resistance." Microbiology Independent Research Journal 4, no. 1 (2017): 31–51. https://doi.org/10.18527/2500-2236-2017-4-1-31-51.

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   Hundreds of thousands of people are dying every year in the world from infections caused by drug resistant bacteria. Antibiotic resistance is a rapidly increasing problem mostly as a result of the worldwide overuse and misuse of antibiotics for conditions that do not require them. The rapid spread of antibiotic resistance in bacteria makes it necessary to intensify the development of new antibiotics and new methods to combat drug resistant bacteria. The goal of this publication is to review the approaches to finding new antibiotics that are active against drug resistant bacteria.

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Nazarov, Pavel A. "MDR Pumps as Crossroads of Resistance: Antibiotics and Bacteriophages." Antibiotics 11, no. 6 (2022): 734. http://dx.doi.org/10.3390/antibiotics11060734.

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At present, antibiotic resistance represents a global problem in modern medicine. In the near future, humanity may face a situation where medicine will be powerless against resistant bacteria and a post-antibiotic era will come. The development of new antibiotics is either very expensive or ineffective due to rapidly developing bacterial resistance. The need to develop alternative approaches to the treatment of bacterial infections, such as phage therapy, is beyond doubt. The cornerstone of bacterial defense against antibiotics are multidrug resistance (MDR) pumps, which are involved in antibi

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Stojanov, Igor, Aleksandar Milovanović, Tomislav Barna, et al. "Antimicrobial Resistance as a Problem for the Quality of Boar Semen." Acta Veterinaria 70, no. 1 (2020): 136–46. http://dx.doi.org/10.2478/acve-2020-0010.

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AbstractThe aim of the study was to determine whether the bacteria from the environment and from the mucous membrane of the boar prepuce have antimicrobial resistance and whether the result obtained is similar/same to the bacteria that can be found in native boar semen. The study addresses the problem of the presence of primarily resistant bacterial strains in the boar sperm, which, due to their reduced sensitivity, cannot be suppressed by antibiotics used in the semen dilution agent, as well as to emphasize the importance of microbiological monitoring of the boar mucous membranes and ambient

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6

Bockstael, Katrijn, and Arthur Aerschot. "Antimicrobial resistance in bacteria." Open Medicine 4, no. 2 (2009): 141–55. http://dx.doi.org/10.2478/s11536-008-0088-9.

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AbstractThe development of antimicrobial resistance by bacteria is inevitable and is considered as a major problem in the treatment of bacterial infections in the hospital and in the community. Despite efforts to develop new therapeutics that interact with new targets, resistance has been reported even to these agents. In this review, an overview is given of the many therapeutic possibilities that exist for treatment of bacterial infections and how bacteria become resistant to these therapeutics.

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Ombašić, A. "An Insight into Antibiotic Resistance Mechanisms: Microbiological Implications for Public Health." Acta Microbiologica Bulgarica 40, no. 2 (2024): 131–41. http://dx.doi.org/10.59393/amb24400201.

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Antibiotics are antimicrobial agents that target bacteria to treat and prevent bacterial infections. They work by interfering with vital bacterial functions, such as the synthesis of nucleic acid, cell wall, and folate, but also disrupting the plasma membrane and ribosome function. Bacteriostatic antibiotics inhibit bacterial growth and those that are bactericidal kill bacteria. Unfortunately, over time, bacteria have become resistant to antibiotics. This resistance can occur through intrinsic or acquired mechanisms, and bacteria may contain more than one type of bacterial resistance. Bacteria

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Vetrova, Anna A., Anastasia A. Ivanova, Kirill V. Petrikov, Olga Gavrichkova, Maria V. Korneykova, and Olesya I. Sazonova. "Antibiotic Resistance as a Functional Characteristic of Urban Dust Particles’ Microbial Communities." Biology 13, no. 12 (2024): 1022. https://doi.org/10.3390/biology13121022.

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Urban dust samples were collected in Moscow (Russia) in June 2021. The samples were collected in three functional zones of Moscow (traffic, residential, and recreational) and included air microparticles, leaf dust, and paved dust. Data on the taxonomic composition of bacterial communities were obtained for dust samples, and their functional characteristics were predicted using PICRUSt2 2.5.0 and FAPROTAX 1.8.0 software. The culturable part of the bacterial community was examined for the presence of antibiotic-resistant strains with respect to β-lactams, tetracyclines, amphenicols, and aminogly

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9

Uddin, Md Jalal, Jirapat Dawan, Gibeom Jeon, Tao Yu, Xinlong He, and Juhee Ahn. "The Role of Bacterial Membrane Vesicles in the Dissemination of Antibiotic Resistance and as Promising Carriers for Therapeutic Agent Delivery." Microorganisms 8, no. 5 (2020): 670. http://dx.doi.org/10.3390/microorganisms8050670.

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The rapid emergence and spread of antibiotic-resistant bacteria continues to be an issue difficult to deal with, especially in the clinical, animal husbandry, and food fields. The occurrence of multidrug-resistant bacteria renders treatment with antibiotics ineffective. Therefore, the development of new therapeutic methods is a worthwhile research endeavor in treating infections caused by antibiotic-resistant bacteria. Recently, bacterial membrane vesicles (BMVs) have been investigated as a possible approach to drug delivery and vaccine development. The BMVs are released by both pathogenic and

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Aya Talib jawad, Hanan Saadon, Sarah Ghalib Khudhur, et al. "Detection of Antibiotic Resistance among Gram-Negative Bacteria Isolated from Urinary Tract Infections." University of Thi-Qar Journal of Science 11, no. 1 (2024): 83–87. http://dx.doi.org/10.32792/utq/utjsci/v11i1.1195.

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This study showed all isolates of bacteria are identified by many testes , such as morphological, biochemical, and API20E testes, as, the results confirmed that the Gram-negative bacteria in Thi-Qar government during the period of June and July 2023-2024. A total of 60 non-duplicate urine samples from patients are collected and examined for detection of Gram-negative bacteria. The results show that out of 60 urine samples 35(58.33%) samples are positive for bacterial growth of Gram negative. The results of bacterial diagnosis depending on testing showed that the frequency of bacterial pathogen

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Kačániová, Miroslava, Margarita Terentjeva, Simona Kunová, Petra Borotová, Peter Haščík, and Jana Štefániková. "Slovak Sheep Cheese Bryndza as a Reservoir of Antimicrobial-Resistant Bacteria." Advanced Research in Life Sciences 4, no. 1 (2020): 79–86. http://dx.doi.org/10.2478/arls-2020-0022.

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Abstract The aim of this study was to determine antibiotic resistance of bacteria isolated from sheep cheese “bryndza”. The cheese samples were obtained from five Slovak farms and different groups of bacteria isolated from cheese samples. Enterobacteriaceae and Lactobacillaceae were the most distributed bacterial families with other bacterial families as Enterococcaceae, Staphylococcaceae and Moraxellaceae were identified. Enterobacteriaceae were tested to cefepime (cephalosporins) and imipenem (carbapenems), Lactobacillaceae family were tested for resistance to vancomycin (glycosides) and to

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Aruhomukama, Dickson, Ivan Sserwadda, and Gerald Mboowa. "Investigating colistin drug resistance: The role of high-throughput sequencing and bioinformatics." F1000Research 8 (February 4, 2019): 150. http://dx.doi.org/10.12688/f1000research.18081.1.

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Bacterial infections involving antibiotic resistant gram-negative bacteria continue to increase and represent a major global public health concern. Resistance to antibiotics in these bacteria is mediated by chromosomal and/or acquired resistance mechanisms, these give rise to multi-drug resistant (MDR) or extensive drug resistant (XDR) bacterial strains. Most recently, a novel acquired plasmid mediated resistance mechanism to colistin, an antibiotic that had been set apart as the last resort antibiotic in the treatment of infections involving MDR and XDR gram-negative bacteria, has been report

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Aruhomukama, Dickson, Ivan Sserwadda, and Gerald Mboowa. "Investigating colistin drug resistance: The role of high-throughput sequencing and bioinformatics." F1000Research 8 (May 20, 2019): 150. http://dx.doi.org/10.12688/f1000research.18081.2.

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Bacterial infections involving antibiotic-resistant gram-negative bacteria continue to increase and represent a major global public health concern. Resistance to antibiotics in these bacteria is mediated by chromosomal and/or acquired resistance mechanisms, these give rise to multi-drug resistant (MDR), extensive-drug resistant (XDR) or pan-drug resistant (PDR) bacterial strains. Most recently, plasmid-mediated resistance to colistin, an antibiotic that had been set apart as the last resort antibiotic in the treatment of infections involving MDR, XDR and PDR gram-negative bacteria has been rep

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García-Contreras, Rodolfo, Toshinari Maeda, and Thomas K. Wood. "Resistance to Quorum-Quenching Compounds." Applied and Environmental Microbiology 79, no. 22 (2013): 6840–46. http://dx.doi.org/10.1128/aem.02378-13.

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ABSTRACTBacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching co

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Růžičková, Michaela, Monika Vítězová, and Ivan Kushkevych. "The characterization of Enterococcus genus: resistance mechanisms and inflammatory bowel disease." Open Medicine 15, no. 1 (2020): 211–24. http://dx.doi.org/10.1515/med-2020-0032.

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AbstractThe constantly growing bacterial resistance against antibiotics is recently causing serious problems in the field of human and veterinary medicine as well as in agriculture. The mechanisms of resistance formation and its preventions are not well explored in most bacterial genera. The aim of this review is to analyse recent literature data on the principles of antibiotic resistance formation in bacteria of the Enterococcus genus. Furthermore, the habitat of the Enterococcus genus, its pathogenicity and pathogenicity factors, its epidemiology, genetic and molecular aspects of antibiotic

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Kuyet, Zichat Blessing, Ahmed Akorede Zakarriyah, Adaobi Fiona Nwokeji, et al. "Pyocin as an Alternative for Antibiotic Resistance." International Journal of Pathogen Research 14, no. 2 (2025): 58–69. https://doi.org/10.9734/ijpr/2025/v14i2350.

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Antimicrobial resistance (AMR) poses a major threat to health worldwide. Undermining decades of progress in medical science, pyocin, a bacteriocin synthesized by Pseudomonas aeruginosa, has caught the attention of academics as a viable alternative to conventional antibiotics. In particular, the usefulness of pyocin in combating multidrug-resistant organisms (MDROs), such as methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, is underlined by its properties. This is especially important for pyocin strains that target antibiotic-resistant bacteria. Pyocins are released

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Sarah, Kassab Shandaway Al-Zamali, Saad Mohammed Shahad, Abdul Abbas Naser Salena, and A. Al-fahham Ali. "Bacterial Resistance to Antibiotics: A Review Article." INTERNATIONAL JOURNAL OF HEALTH & MEDICAL RESEARCH 03, no. 08 (2024): 590–93. https://doi.org/10.5281/zenodo.13359555.

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Antibacterial resistance (ABR) is nowadays considered as a public global health problem, with expected mortality rate of 106 yearly by 2050. ABR happens when pathogenic bacteria are not affected to antibacterial therapy, resulting in the spread of the pathogens inside the host. Antibacterial resistance in pathogenic bacteria is a significant concern that is correlated with high rates of deaths and illness. Bacterial resistance to many antibiotics in Gram- negative and – positive bacteria can’t be treated easily and might not be irradicated by conventional antimicrobials. Resistance

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Cepas, Virginio, and Sara M. Soto. "Relationship between Virulence and Resistance among Gram-Negative Bacteria." Antibiotics 9, no. 10 (2020): 719. http://dx.doi.org/10.3390/antibiotics9100719.

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Bacteria present in the human body are innocuous, providing beneficial functions, some of which are necessary for correct body function. However, other bacteria are able to colonize, invade, and cause damage to different tissues, and these are categorised as pathogens. These pathogenic bacteria possess several factors that enable them to be more virulent and cause infection. Bacteria have a great capacity to adapt to different niches and environmental conditions (presence of antibiotics, iron depletion, etc.). Antibiotic pressure has favoured the emergence and spread of antibiotic-resistant ba

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Arooj, Iqra, Alishba Sehar, and Asghar Javaid. "Prevalence and Antibiotic Sensitivity pattern of Bacterial Isolates from Catheterized UTI Patients: A Local Study." Pakistan Journal of Biochemistry and Biotechnology 2, no. 2 (2021): 229–35. http://dx.doi.org/10.52700/pjbb.v2i2.88.

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Prevalence and multidrug resistance among bacteria in catheter-associated urinary tract infections (CAUTIs) has been on the rise in recent times. Hence, the prevalence rate and antibacterial susceptibility of bacteria in CAUTIs in ICU patients was evaluated. A total of 120 patients admitted to the ICU of Nishtar Hospital, Multan, were recruited for this study. Both gram-positive and gram-negative bacterial isolates were characterized based on biochemical tests including catalase test, oxidase test, indole test, TSI test, citrate test, coagulase test and growth on 6.5% NaCl agar. The prevalence

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Adesola, Ridwan Olamilekan. "How Mobility of Resistance Determinants Affects the Dissemination of Antimicrobial Resistance?" International Journal of Travel Medicine and Global Health 10, no. 3 (2022): 90–98. http://dx.doi.org/10.34172/ijtmgh.2022.17.

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Antibiotic resistance is primarily propagated by mobile genetic elements (MGEs) around the world. As a result, antibiotic resistance genes can be found in a wide spectrum of environmental microorganisms. Environmental bacteria are not resistant to all antibiotics now accessible, despite long histories of antibiotic development and exposure. As a result, obtaining a complete resistance arsenal will be challenging. The goal of this study is to look at how the mobility of resistance determinants influences antimicrobial resistance spread. The sources, distribution, and development of resistance m

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Hervin, Vincent, Vincent Roy, and Luigi A. Agrofoglio. "Antibiotics and Antibiotic Resistance—Mur Ligases as an Antibacterial Target." Molecules 28, no. 24 (2023): 8076. http://dx.doi.org/10.3390/molecules28248076.

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The emergence of Multidrug Resistance (MDR) strains of bacteria has accelerated the search for new antibacterials. The specific bacterial peptidoglycan biosynthetic pathway represents opportunities for the development of novel antibacterial agents. Among the enzymes involved, Mur ligases, described herein, and especially the amide ligases MurC-F are key targets for the discovery of multi-inhibitors, as they share common active sites and structural features.

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Roque-Borda, Cesar Augusto, Patricia Bento da Silva, Mosar Corrêa Rodrigues, et al. "Challenge in the Discovery of New Drugs: Antimicrobial Peptides against WHO-List of Critical and High-Priority Bacteria." Pharmaceutics 13, no. 6 (2021): 773. http://dx.doi.org/10.3390/pharmaceutics13060773.

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Bacterial resistance has intensified in recent years due to the uncontrolled use of conventional drugs, and new bacterial strains with multiple resistance have been reported. This problem may be solved by using antimicrobial peptides (AMPs), which fulfill their bactericidal activity without developing much bacterial resistance. The rapid interaction between AMPs and the bacterial cell membrane means that the bacteria cannot easily develop resistance mechanisms. In addition, various drugs for clinical use have lost their effect as a conventional treatment; however, the synergistic effect of AMP

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Khaitovych, M. V. "EFFLUX PUMPS AS A PHARMACOLOGICAL TARGET TO COMBAT ANTIBIOTIC RESISTANCE." Medical Science of Ukraine (MSU) 19, no. 3 (2023): 115–24. http://dx.doi.org/10.32345/2664-4738.3.2023.15.

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Backround. Antibiotic resistance is the resistance of bacteria to antimicrobial drugs to which they were previously sensitive. A particular danger is the spread of multidrug-resistant healthcare-associated infections of "ESKAPE" group. Among the mechanisms of antibiotic resistance of these bacteria, the activation of efflux pumps attracts special attention. Aim: to review the current data on the possibility of using efflux pumps as targets for pharmacological action to overcome antibiotic resistance. Materials and methods. Analysis of the data presented in PubMed by keywords "antim

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Perovic, Svetlana, Gorana Veinovic, and Jelena Antic-Stankovic. "A review on antibiotic resistance: Origin and mechanisms of bacterial resistance as biological phenomenon." Genetika 50, no. 3 (2018): 1123–35. http://dx.doi.org/10.2298/gensr1803123p.

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Antimicrobial resistance is a natural biological phenomenon in their struggle for existence and represents a major health care issue, associated with high mortality and morbidity. The first cases of mass emergence of resistant strains were observed in the middle of the 20th century, and since then cases of resistance have been reported all over the world, and in the last two decades even more frequently are reported multiple bacterial resistance. Factors that contribute to the development of bacteria resistance are abuse in the use of antibacterial agents, in humans or livestock, and releases

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FAN, Xiaojing, Tahira SALEEM, and Huasong ZOU. "Copper resistance mechanisms in plant pathogenic bacteria." Phytopathologia Mediterranea 61, no. 1 (2022): 129–38. http://dx.doi.org/10.36253/phyto-13282.

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Copper is an essential element for microbes as it is involved in many redox reactions. Numerous resistance systems have been evolved in microbes to maintain copper homeostasis under copper stress conditions. These systems are responsible for the influx and efflux of copper ions in the cells. In phytopathogenic bacteria, copper ions play essential roles during disease development in plants. Copper-based chemicals are extensively used for control of diseases caused by bacteria, which leads to induced pathogen resistance derived from various copper resistance systems. Previous studies have shown

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Irawati, Wahyu, Polin P. Ambarita, Vannesa El Shaday, and Sintia Y. Rahmawati. "Bakteri Indigen yang Diisolasi dari Danau Toba: Acinetobacter junii DT2.1 Multiresisten Tembaga, Methylen Blue, dan Basic Fuchine." JURNAL BIOLOGI PAPUA 15, no. 2 (2023): 130–37. http://dx.doi.org/10.31957/jbp.2804.

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Lake Toba is one of the industrial waste disposal sites around the location. Copper and dyes are pollutants that are toxic and harmful to organisms. Bioremediation using indigenous bacteria isolated from polluted sites is a promising solution to overcome environmental pollution. Bacteria that have multi-resistance to copper and dyes are expected to increase the efficiency of industrial waste treatment. This study aims to: 1) isolate and characterize copper-resistant bacteria, 2) determine the level of resistance of bacterial isolates to copper, 3) test the resistance of bacteria to dyes. Physi

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Purnawati, Arika, Wiwik Harjani, and Herry Nirwanto. "Selection and Formulation of Endophytic Bacteria as Plant Resistance Elicitor against Wilt Disease of Tomato." Agrotechnology Research Journal 3, no. 2 (2019): 103. http://dx.doi.org/10.20961/agrotechresj.v3i2.33866.

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<p>Wilt disease of <em>Solanaceae</em> caused by <em>Ralstonia solanacearum</em> reduce the crop quality and negatively affect the crop product. The objective of this research was to discover of endophytic bacteria formulation that effectively decreases bacterial which cause wilt disease on <em>Solanaceae</em>. The research consisted of purification of <em>Ralstonia solanacearum</em>, endophytic bacteria were obtained from the sample and the screening of endophytic bacteria using this following assay: antagonist assay, seedling assay and &l

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Djuikoue, Cecile Ingrid, Willy Yamdeu Djonkouh, Cavin Epie Bekolo, et al. "Prevalence and Antibiotic Resistance Pattern of Streptococcus, Staphylococcus, Neisseria meningitidis and Enterobacteriaceae in Two Reference Hospitals of Yaoundé: An Overview before and during COVID-19 Pandemic Era." Antibiotics 12, no. 5 (2023): 929. http://dx.doi.org/10.3390/antibiotics12050929.

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The COVID-19 pandemic led to tremendously use of antimicrobial due to the lack of proper treatment strategies, raising concerns about emergence of antimicrobial resistance (AMR). This study aimed at determining the prevalence and antibiotic resistance pattern of selected bacteria isolates in 02 referral health facilities in Yaoundé before and during the COVID-19 pandemic era. We conducted a retrospective study over a period of 03 years (from 1 January 2019 to 31 December 2021) in the bacteriology units of the Central and General Hospitals of Yaoundé, Cameroon. Data on bacteria genera (Streptoc

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Khaliq, Tayyaba, and Muhammad Imran Qadir. "Phage Therapy as an alternative to Antibiotic Therapy against Urinary Tract Infections to Combat Antibiotic Resistance." JOURNAL OF MICROBIOLOGY AND MOLECULAR GENETICS 2, no. 2 (2021): 9–21. http://dx.doi.org/10.52700/jmmg.v2i2.30.

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Urinary tract infection is the global health problem being 2nd most common bacterial infection. The abuse of antibiotics without bacterial characterization during its treatment results in emergence of highly antibiotic-resistant bacteria. Some biofilm forming bacterial strains are hard to treat using antibiotics. So, an alternative therapy is urgently needed. Phage therapy offers promising results for treatment of these infections in which virulent or lytic phages are used to lyse infection-causing bacterial cells. This review emphasizes several ways in which phage therapy can be carried out a

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Hamadamin, Hamadamin Zrar, Ahmed Farhan Shallal, and Ibrahim Nazem Qader. "Synergistic role of Extended-spectrum beta-lactamases (ESBL) and bacterial structure on antibacterial drugs." Jabirian Journal of Biointerface Research in Pharmaceutics and Applied Chemistry 1, no. 3 (2024): 26–36. https://doi.org/10.55559/jjbrpac.v1i3.293.

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The illnesses induced by pathogenic microorganisms, particularly bacteria, are progressively on the rise at a global scale. Antibiotics, whether derived from specific microorganisms naturally or altered chemically, play a vital role in managing bacterial infections. These pharmaceuticals hinder or eradicate bacteria through a variety of mechanisms, which include impeding the synthesis of cell walls or cell membranes, inhibiting the production of proteins and specific metabolites, as well as thwarting the synthesis of nucleic acids. Nevertheless, bacteria have the ability to acquire resistance

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Hasan, Mahadi, and Juhee Ahn. "Evolutionary Dynamics between Phages and Bacteria as a Possible Approach for Designing Effective Phage Therapies against Antibiotic-Resistant Bacteria." Antibiotics 11, no. 7 (2022): 915. http://dx.doi.org/10.3390/antibiotics11070915.

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With the increasing global threat of antibiotic resistance, there is an urgent need to develop new effective therapies to tackle antibiotic-resistant bacterial infections. Bacteriophage therapy is considered as a possible alternative over antibiotics to treat antibiotic-resistant bacteria. However, bacteria can evolve resistance towards bacteriophages through antiphage defense mechanisms, which is a major limitation of phage therapy. The antiphage mechanisms target the phage life cycle, including adsorption, the injection of DNA, synthesis, the assembly of phage particles, and the release of p

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Patzak, Melanie S., Volker Ellenrieder, and Albrecht Neesse. "Intratumoral bacteria as potential contributor of gemcitabine resistance." Translational Cancer Research 7, S1 (2018): S21—S23. http://dx.doi.org/10.21037/tcr.2017.12.21.

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Ahmed, Nashida. "Vegetables and Fruit as a Reservoir of Mobilized Colistin Resistance (MCR) Positive Gram-Negative Bacteria." International Journal of Clinical Case Reports and Reviews 22, no. 3 (2025): 01–12. https://doi.org/10.31579/2690-4861/659.

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It has been widely acknowledged that “antimicrobial resistance” which makes antibiotic treatment of bacterial disease ineffective, is one of the most urgent health risks that the world is currently facing. Food chain is one of the major pathways of spread of this antibiotic resistance which is a great public health challenge. Colistin, an orally active polypeptide antibiotic has excellent activity against various Gram-negative bacteria and last-resort therapy used against infections caused by these bacteria. In November 2015, a novel plasmid-mediated colistin resistance gene, mcr-1, was identi

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Nobel, Fahim, Hasib Ahammad, Sumita Saha, et al. "Determination of multidrug resistance profile of isolated Gram-positive and Gram-negative bacteria from clinical pus samples in Bangladesh." Journal of Advanced Biotechnology and Experimental Therapeutics 7, no. 1 (2024): 178. http://dx.doi.org/10.5455/jabet.2024.d16.

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Introduction: Antimicrobial resistance (AMR) has been a very concerning issue with consistent rise on a global scale. The rapid spread of drug-resistant pathogenic bacteria is a serious public health concern in both developed and developing countries, including Bangladesh. This study aimed to determine the prevalence of antibiotic resistant pathogenic bacteria in pus samples and their multidrug resistance (MDR) rate. Methods: A total of 891 pus positive samples were collected from the Lab Zone and Hormone center in Tangail, Bangladesh between January 2018 to March 2022. The standard microbiolo

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Dr, Chandra Sekhar Mohapatra, Shilpa Pande Dr., Jain Shreesh, Chahat Shikarwar Dr., Bhavitha Panamareddy, and Vyankatrao Mali Sharad. "Nanotechnology as a Potential Method for Combating Multidrug-Resistant Bacteria: A Comprehensive Analysis & Future Prospects." International Journal of Innovative Science and Research Technology 8, no. 5 (2023): 1657–60. https://doi.org/10.5281/zenodo.7992780.

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Nanotechnology is emerging as new implementations that can be used directly or indirectly to combat lethal bacterial infections & surmount antibiotic resistance. Antibiotic overuse is on the rise due to factors including an ageing population, a rise in infectious illnesses, & the frequency of chronic conditions that need their treatment. The broad distribution of resistance genes at an environmental scale may be traced back to the extra & inadvisable utilisation of antibiotics by humans, which has led to the rise of bacteria resistance to existing antibiotics & the selective gr

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Biyela, P. T., J. Lin, and C. C. Bezuidenhout. "The role of aquatic ecosystems as reservoirs of antibiotic resistant bacteria and antibiotic resistance genes." Water Science and Technology 50, no. 1 (2004): 45–50. http://dx.doi.org/10.2166/wst.2004.0014.

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The widespread and indiscriminate use of antibiotics has led to the development of antibiotic resistance in pathogenic, as well as commensal, microorganisms. Resistance genes may be horizontally or vertically transferred between bacterial communities in the environment. The recipient bacterial communities may then act as a reservoir of these resistance genes. In this study, we report the incidence of antibiotic resistance in enteric bacteria isolated from the Mhlathuze River and the distribution of genetic elements that may be responsible for the observed antibiotic resistance. The resistance

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Okoye, Ebele L., Christian Kemakolam, Emmanuel T. Ugwuoji, and Ifeoma Ogbonna. "Multidrug Resistance Tracing by Plasmid Profile Analysis and the Curing of Bacteria from Different Clinical Specimens." Advanced Gut & Microbiome Research 2022 (October 11, 2022): 1–12. http://dx.doi.org/10.1155/2022/3170342.

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Human-pathogenic bacteria resistant to one or multiple antibiotics have dramatically increased worldwide in the past decades. These bacteria possess great danger, have become a global issue, and it is now impossible to avoid developing strategies for the restoration of treatment options against infections caused by them. This research aims at profiling plasmids of multidrug-resistant bacteria from various clinical specimens such as ear exudate, sputum, urethral swab, wound swab, urine from the catheter, urine, nasal swab, high vaginal swab, stool, eye swab, and blood at Chukwuemeka Odumegwu Oj

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Schjørring, Susanne, and Karen A. Krogfelt. "Assessment of Bacterial Antibiotic Resistance Transfer in the Gut." International Journal of Microbiology 2011 (2011): 1–10. http://dx.doi.org/10.1155/2011/312956.

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We assessed horizontal gene transfer between bacteria in the gastrointestinal (GI) tract. During the last decades, the emergence of antibiotic resistant strains and treatment failures of bacterial infections have increased the public awareness of antibiotic usage. The use of broad spectrum antibiotics creates a selective pressure on the bacterial flora, thus increasing the emergence of multiresistant bacteria, which results in a vicious circle of treatments and emergence of new antibiotic resistant bacteria. The human gastrointestinal tract is a massive reservoir of bacteria with a potential f

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Liu, Yutong, and Xuanrong Xu. "Drug Resistance of Ocular Bacteria Considering Biofilm Mechanism." E3S Web of Conferences 271 (2021): 03041. http://dx.doi.org/10.1051/e3sconf/202127103041.

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In order to further analyze the relationship between the coating mechanism of microorganisms and their drug resistance, a study of ocular bacterial drug resistance considering the coating mechanism of microorganisms was proposed. Firstly, the mechanism of drug resistance was analyzed, and on this basis, the experimental study was carried out. Staphylococcus aureus DH5 with RP4 was used as the control α( R) Objective to investigate the relationship between drug-resistant bacteria and coating mechanism in the cross genus conjugation system of Pseudomonas aeruginosa PAOi and donor bacteria. The c

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Singh, Sunita, Ruchi Dube, and Arpita Gupte. "Characterization of Multi Heavy Metal Tolerant Bacterial Isolate from Middle Gangetic Plains, India." International Journal of Ecology and Environmental Sciences 50, no. 3 (2024): 349–53. http://dx.doi.org/10.55863/ijees.2024.0009.

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The research focuses on antibiotic resistance profiles and bacterial compatibility in multi-heavy metal-tolerant bacterial strains. It reveals significant concerns about antibiotic resistance in these bacteria, including resistance to penicillin, streptomycin, tetracycline, ampicillin, and vancomycin. Notably, 96% of the isolates exhibited resistance to vancomycin. The study emphasizes the need for prudent antibiotic use to combat its resistance. Conversely, tetracycline and penicillin showed lower resistance levels at 85 and 77%, respectively, in line with previous research showing diverse re

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Khabthani, Sami, Jean-Marc Rolain, and Vicky Merhej. "Whole Genome Analysis of 335 New Bacterial Species from Human Microbiota Reveals a Huge Reservoir of Transferable Antibiotic Resistance Determinants." International Journal of Molecular Sciences 23, no. 4 (2022): 2137. http://dx.doi.org/10.3390/ijms23042137.

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Background: The emergence and diffusion of strains of pathogenic bacteria resistant to antibiotics constitutes a real public health challenge. Antibiotic resistance genes (ARGs) can be carried by both pathogenic and non-pathogenic bacteria, including commensal bacteria from the human microbiota, which require special monitoring in the fight against antimicrobial resistance. Methods: We analyzed the proteomes of 335 new bacterial species from human microbiota to estimate its whole range of ARGs using the BLAST program against ARGs reference databases. Results: We found 278 bacteria that harbor

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Rueda-Robles, Ascensión, Avilene Rodríguez-Lara, Matthew S. Meyers, María José Sáez-Lara, and Ana I. Álvarez-Mercado. "Effect of Probiotics on Host-Microbiota in Bacterial Infections." Pathogens 11, no. 9 (2022): 986. http://dx.doi.org/10.3390/pathogens11090986.

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Diseases caused by bacteria cause millions of deaths every year. In addition, the problem of resistance to antibiotics is so serious that it threatens the achievements of modern medicine. This is a very important global problem as some bacteria can also develop persistence. Indeed, the persistence of pathogenic bacteria has evolved as a potent survival strategy to overcome host organisms’ defense mechanisms. Additionally, chronic or persistent infections may be caused by persisters which could facilitate antibiotic resistance. Probiotics are considered good bacteria. It has been described that

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Miranda, Claudio D., Christopher Concha, Félix A. Godoy, and Matthew R. Lee. "Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance." Antibiotics 11, no. 11 (2022): 1487. http://dx.doi.org/10.3390/antibiotics11111487.

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The disposal of antibiotics in the aquatic environment favors the selection of bacteria exhibiting antibiotic resistance mechanisms. Quinolones are bactericidal antimicrobials extensively used in both human and animal medicine. Some of the quinolone-resistance mechanisms are encoded by different bacterial genes, whereas others are the result of mutations in the enzymes on which those antibiotics act. The worldwide occurrence of quinolone resistance genes in aquatic environments has been widely reported, particularly in areas impacted by urban discharges. The most commonly reported quinolone re

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Koshova, Olena, Nataliia Filimonova, Larysa Mozghova, and Iryna Tishchenko. "Bacterial plasmids: the role in the development of resistance to antimicrobial compounds." ScienceRise: Biological Science, no. 2(39) (October 9, 2024): 4–8. https://doi.org/10.15587/2519-8025.2024.311822.

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The rapid increase in the prevalence of multiple drug resistance of pathogenic microorganisms poses a critical threat to public health worldwide, which significantly contributes to the increase in patient mortality and morbidity. Classical agents, used in the past for treatment, are losing their effectiveness, moreover, many of the newer available drugs have already become targets for bacterial resistance mechanisms. As a result, the treatment of infections becomes more complicated, and the total costs of treatment increase. Purpouse. In this work, we aimed to evaluate the role of plasmids in

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Jiang, S., J. Zeng, X. Zhou, and Y. Li. "Drug Resistance and Gene Transfer Mechanisms in Respiratory/Oral Bacteria." Journal of Dental Research 97, no. 10 (2018): 1092–99. http://dx.doi.org/10.1177/0022034518782659.

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Growing evidence suggests the existence of new antibiotic resistance mechanisms. Recent studies have revealed that quorum-quenching enzymes, such as MacQ, are involved in both antibiotic resistance and cell-cell communication. Furthermore, some small bacterial regulatory RNAs, classified into RNA attenuators and small RNAs, modulate the expression of resistance genes. For example, small RNA sprX, can shape bacterial resistance to glycopeptide antibiotics via specific downregulation of protein SpoVG. Moreover, some bacterial lipocalins capture antibiotics in the extracellular space, contributin

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Yang, Hua, Brittany Dettman, Jonathan Beam, Caroline Mix, and Xiuping Jiang. "Occurrence of ceftriaxone-resistant commensal bacteria on a dairy farm and a poultry farm." Canadian Journal of Microbiology 52, no. 10 (2006): 942–50. http://dx.doi.org/10.1139/w06-049.

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Approximately 40 samples of animal feces, drinking water, feed, bedding, pine wood shavings, compost, and manure slurry were collected from two animal research farms (one dairy and one poultry) and analyzed for ceftriaxone-resistant bacteria. Our study revealed that the total percentage of aerobic bacteria with reduced susceptibility to ceftriaxone (minimal inhibitory concentration (MIC) ≥ 16 µg/mL) ranged from 0.9% to 10.8% in dairy feces and from 0.05% to 3.93% in chicken feces. The percentages of ceftriaxone-resistant bacteria (MIC ≥ 64 µg/mL) were in the range of 0.01%–2.3% in dairy feces

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Stephen, Jashilagari, Abubakar Sadiq Lawan, Stephen Bitrus Balami, et al. "Vaginal Bacterial Isolation and Antimicrobial Susceptibility Patterns from Non-Pregnant Sahel Goats." Sahel Journal of Life Sciences FUDMA 3, no. 1 (2025): 299–303. https://doi.org/10.33003/sajols-2025-0301-36.

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Antimicrobial resistance (AMR) poses a significant global health challenge. The emergence of AMR is particularly disturbing as it can have far-reaching consequences for animal health, human health, and the environment. This study investigated the occurrence of vaginal bacteria and their antimicrobial susceptibility patterns amongst non-pregnant Sahel goats. Sahel goats are a distinct population found in the Sahel region of Africa. Vaginal samples from 25 goats were examined. Fifteen (15) out of 25 samples (60%) had bacterial growth, which yielded Sixty-four (64) bacterial isolates. The isolate

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Indraningrat, Anak Agung Gede, Pande Putu Christine Putri Purnami, Anak Agung Sri Agung Aryastuti, and Made Dharmesti Wijaya. "Antibacterial Activity of Pseudomonas Aeruginosa ISP1RL3 Against Multidrug Resistance Bacteria." Jurnal Penelitian Pendidikan IPA 9, no. 12 (2023): 11126–36. http://dx.doi.org/10.29303/jppipa.v9i12.5643.

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Seaweed-associated bacteria have a pivotal role to synthesize arrays of secondary metabolites. This study described a bacterial isolate encoded as ISP1RL3 that was isolated from seaweed Eucheuma cottonii. Ethyl acetate extracts of ISP1RL3 was screened against non-multidrug bacteria (Staphylococcus aureus ATCC 25923, Streptococcus mutans FNCC 0405, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603) and multi-drug resistance bacteria (Methicilin-resistance S. aureus (MRSA), E. coli ESBL, K. pneumoniae ESBL, dan A.baumanii ESBL). Our result showed that ISP1RL3 displayed rod structure

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Bhutani, Natasha, Chithra Muraleedharan, Deepa Talreja, et al. "Occurrence of Multidrug Resistant Extended Spectrum Beta-Lactamase-Producing Bacteria on Iceberg Lettuce Retailed for Human Consumption." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/547547.

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Antibiotic resistance in bacteria is a global problem exacerbated by the dissemination of resistant bacteria via uncooked food, such as green leafy vegetables. New strains of bacteria are emerging on a daily basis with novel expanded antibiotic resistance profiles. In this pilot study, we examined the occurrence of antibiotic resistant bacteria against five classes of antibiotics on iceberg lettuce retailed in local convenience stores in Rochester, Michigan. In this study, 138 morphologically distinct bacterial colonies from 9 iceberg lettuce samples were randomly picked and tested for antibio

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Jones, Allison, Miriam Geörg, Lisa Maudsdotter, and Ann-Beth Jonsson. "Endotoxin, Capsule, and Bacterial Attachment Contribute to Neisseria meningitidis Resistance to the Human Antimicrobial Peptide LL-37." Journal of Bacteriology 191, no. 12 (2009): 3861–68. http://dx.doi.org/10.1128/jb.01313-08.

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ABSTRACT Pathogenic bacteria have evolved numerous mechanisms to evade the human immune system and have developed widespread resistance to traditional antibiotics. We studied the human pathogen Neisseria meningitidis and present evidence of novel mechanisms of resistance to the human antimicrobial peptide LL-37. We found that bacteria attached to host epithelial cells are resistant to 10 μM LL-37 whereas bacteria in solution or attached to plastic are killed, indicating that the cell microenvironment protects bacteria. The bacterial endotoxin lipooligosaccharide and the polysaccharide capsule

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