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Journal articles on the topic 'Axe HPA'

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Published: 4 June 2021

Last updated: 9 February 2022

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1

Anani Sarab, Gholamreza, Michael Moss, Robert N. Barker, and Stanislaw J. Urbaniak. "Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101–positive antigen-presenting cells." Blood 114, no. 9 (2009): 1954–57. http://dx.doi.org/10.1182/blood-2009-04-211839.

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AbstractIn neonatal alloimmune thrombocytopenia, almost all human platelet antigen (HPA)–1b1b mothers who produce anti–HPA-1a antibody through carrying an HPA-1a fetus are human histocompatibility leukocyte antigen (HLA)–DRB3*0101 positive. It is predicted that the HPA-1a Leu33 polymorphism forms part of an HLA-DRB3*0101–restricted T-helper epitope, and acts as an anchor residue for binding this class II molecule. However, it is not known whether any corresponding peptides are naturally processed and presented from platelet glycoprotein. In this study, peptides displayed by a homozygous HLA-DR

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2

Salomon, Ophira, Ron Loewenthal, Rivka Kalt, et al. "HLADRB3*0101 Combined with DRB4*0101 Are Potential Predictor of Neonatal Alloimmune Thrombocytopenia (NAIT) Development." Blood 118, no. 21 (2011): 2221. http://dx.doi.org/10.1182/blood.v118.21.2221.2221.

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Abstract Abstract 2221 Neonatal alloimmune thrombocytopenia (NAIT) is a life-threatening bleeding disorder in the fetus/ neonate caused by maternal alloantibodies directed against fetal platelet antigens inherited from the father. Of the 21 allonatigens described up to date http://www.ebi.ac.uk/ipd/hpa/table2.html, the human platelet antigen (HPA) −1 defined as a leucine /proline polymorphism at residue 33 in b3 integrin is the immune-dominant antigen leading to severe NAIT. Immunization to HPA-1a occurs only in 10% of HPA-1bb pregnant women, 90% of them carrying histocompatibility leukocyte a

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Ricotti, Roberta, Marilisa De Feudis, Caterina Peri, et al. "Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity." International Journal of Endocrinology 2020 (July 9, 2020): 1–8. http://dx.doi.org/10.1155/2020/6035138.

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Purpose. Haptoglobin (Hp) is a protein involved in the acute-phase reaction of inflammation. Humans have three major phenotypes (Hp1-1, Hp1-2, and Hp2-2). Several studies have shown altered Hp regulation in adults with obesity and metabolic alterations. The Hp2-2 phenotype is associated with a high cardiovascular risk. Our aim was to investigate if Hp levels and the Hp2-2 phenotype are associated with glucose metabolism in pediatric obesity. Methods. We retrospectively studied 192 participants (92 males and 100 females), aged 4–18 years. Clinical and biochemical data were collected. The Hp phe

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Kjeldsen-Kragh, Jens, Dean A. Fergusson, Mette Kjaer, et al. "Fetal/neonatal alloimmune thrombocytopenia: a systematic review of impact of HLA-DRB3*01:01 on fetal/neonatal outcome." Blood Advances 4, no. 14 (2020): 3368–77. http://dx.doi.org/10.1182/bloodadvances.2020002137.

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Abstract The most common, severe cases of fetal and neonatal alloimmune thrombocytopenia among whites are caused by antibodies against human platelet antigen 1a (HPA-1a). The aims of this systematic review and meta-analysis are to determine the association between maternal HLA-DRB3*01:01 and: (1) HPA-1a-alloimmunization and (2) neonatal outcome in children born of HPA-1a-immunized women. A systematic literature search identified 4 prospective and 8 retrospective studies. Data were combined across studies to estimate pooled odds ratios (ORs) and the associated 95% confidence intervals (CIs). Th

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5

Sarab, Gholamreza Anani, Robert N. Barker, Michael Moss, and Stanislaw Urbaniak. "Analysis of Naturally Processed HPA-1a Peptides Bound to Human MHC Class II Molecules." Blood 112, no. 11 (2008): 290. http://dx.doi.org/10.1182/blood.v112.11.290.290.

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Abstract Background: Human platelet HPA-1a and HPA-1b alloantigens are determined respectively by the polymorphism Leu or Pro at position 33 of the β3 chain (GPIIIa) of the platelet integrin αIIbβ3. In neonatal alloimmune thrombocytopenia (NAITP) the HPA-1b1b mothers who are at risk of producing anti-HPA-1a antibody through carrying an HPA-1a fetus are almost always HLA-DRB3*0101 (DR52a) positive. The T-helper response that drives anti-HPA-1a production remains to be fully characterized. The Th epitope(s) must include the Leu33 polymorphism, which is also predicted to be an anchor residue for

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6

Nogueira-Silva, Leandra Christina, Samira Ali Abbas, Larissa Barbosa Lopes, et al. "Simultaneous Occurrence of Neonatal Alloimmune Thrombocytopenia and Neutropenia Associated with Multiple Maternal Antibodies." Blood 124, no. 21 (2014): 2779. http://dx.doi.org/10.1182/blood.v124.21.2779.2779.

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Abstract Background: Neonatal alloimmune thrombocytopenia (NAIT) results from feto-maternal platelet antigen incompatibility leading to the production of maternal antibodies and destruction of fetal platelets during pregnancy. Similarly neonatal alloimmune neutropenia (NAN) is caused by maternal alloimmunization to incompatible fetal neutrophil antigens followed by transplacental transfer of the maternal anti-neutrophil antibody causing fetal or neonatal neutropenia. Although there are many reports in the literature describing these rare disorders, the simultaneous occurrence of NAIT and NAN h

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7

Vazmitsel, Maryna, Dong Chen, Barbara Gruner, and Emily Coberly. "An Unusual Case of Fetal/Neonatal Alloimmune Thrombocytopenia." American Journal of Clinical Pathology 152, Supplement_1 (2019): S151—S152. http://dx.doi.org/10.1093/ajcp/aqz131.002.

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Abstract Objectives Fetal/neonatal alloimmune thrombocytopenia (FNAIT) occurs when maternal IgG alloantibodies against paternal human platelet antigens (HPA) cross the placenta and cause the destruction of fetal platelets. The vast majority (up to 95%) of FNAIT cases are caused by antibodies against HPA-1a or HPA-5b antigens, while the remaining cases are usually due to antibodies against a variety of other HPA antigens. Cases of FNAIT due to anti-HLA antibodies are extremely uncommon and have only rarely been reported. We present a case of FNAIT suspected to be caused by anti-HLA class I allo

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8

Kang, Ramanjot S., Peter J. Keefe, and James B. Bussel. "Development of Autoimmune Diseases in Women with HPA-1a Alloimmunization and Fetal-Neonatal Alloimmune Thrombocytopenia (FNAIT)." Blood 128, no. 22 (2016): 2556. http://dx.doi.org/10.1182/blood.v128.22.2556.2556.

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Abstract Introduction: Fetal-NeonatalAlloimmune Thrombocytopenia (FNAIT) is the result of an incompatibility between maternal and fetal human platelet alloantigens (HPA). Affecting 1 in 1000 births, it is one of the most common causes of thrombocytopenia in the neonate. Prospective studies reveal that only 5-10% of pregnancies with HPA-1a incompatibilities result in maternalalloimmunization. The association of HPA-1a incompatibility andalloimmunization is largely based on an immune response gene: the Human Leukocyte Antigen (HLA) class II DRB3*0101 haplotype. Clinical studies have shown that &

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9

Sharpe, Christopher J., Robert S. Liwski, Stephen Couban, Irene Sadek, and Eiad B. Kahwash. "HLA- and HPA-Alloimmunization Rate In the Setting of Refractoriness to Platelet Transfusion: A Single Center Study,." Blood 118, no. 21 (2011): 3366. http://dx.doi.org/10.1182/blood.v118.21.3366.3366.

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Abstract Abstract 3366 Background: Refractoriness to platelet transfusion is a common clinical problem occurring in up to 34% of hematology/oncology patients (Hod and Schwartz 2008). While often non-immunologic in etiology, alloimmunization to human leukocyte antigens (HLA) or human platelet antigens (HPA) may contribute to this phenomenon. If patients are refractory to pooled, random donor platelets, most institutions have an explicit algorithm which facilitates a supply of single-donor (SD) apheresis and/or HLA-matched platelets. At our institution, platelet refractoriness is defined as a pl

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10

Rathore, Vipul, Matthew Meyers, and Bryan Ray. "PAKTM-Lx: A New Luminex*®-Based Assay to Detect and Identify Antibodies to Human Platelet Antigens (HPA) in Patient Serum." Blood 114, no. 22 (2009): 4187. http://dx.doi.org/10.1182/blood.v114.22.4187.4187.

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Abstract Abstract 4187 Platelets express a variety of glycoproteins (GPIIb-IIIa, GPIa-IIa, GPIb/IX, GPIV, CD109 and Class I HLA). Human Platelet Antigens (HPA) represent polymorphisms of these platelet surface glycoproteins. While these polymorphisms do not alter the function of the proteins, they can become target of the immune system in mismatched individuals. Alloantibodies against HPA are involved in the pathogenesis of Neonatal Allo-Immune Thrombocytopenia (NAIT), Post-Transfusion Purpura (PTP) and refractoriness to random donor platelets. In addition to generating anti-HPA antibodies, th

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Peterson, Julie A., Adam Kanack, Dhirendra Nayak, et al. "Prevalence and Clinical Significance of Low Avidity HPA-1a Antibodies in Women Exposed to HPA-1a During Pregnancy." Blood 120, no. 21 (2012): 266. http://dx.doi.org/10.1182/blood.v120.21.266.266.

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Abstract Abstract 266 Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal antibodies specific for fetal platelet antigens and is the most common cause of intracranial hemorrhage in full term infants. The antigen HPA-1a, carried on beta 3 integrin (GPIIIa), is the most common trigger for NAIT and the 2% of women who are HPA-1a-negative are at risk to produce such antibodies. Most HPA-1a antibodies causing NAIT can be easily detected but it is not rare for an HPA-1a negative mother who lacks detectable antibodies to give birth to an infant with thrombocytopenia. Several recent repo

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Hashmi, Ghazala, Dipika Patel, Yi Zhang, et al. "Preventing Platelet Alloimmunization for Patients with Hematologic Malignancies: Rapid HLA-class I and HPA Immunogenetic Profiling to Enable Selection of Optimally Matched Platelets." Blood 120, no. 21 (2012): 4691. http://dx.doi.org/10.1182/blood.v120.21.4691.4691.

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Abstract Abstract 4691 Reflecting the lack of an adequate supply of product, the current clinical practice of routinely administering single donor platelets chosen at random – that is: without regard for the specific antigens, primarily HLA and HPA, on donor platelets - exposes patients to a significant risk of alloimmunization and refractoriness in the course of induction chemotherapy. Refractoriness is a serious condition that not only diminishes the effectiveness of the primary treatment, but increases utilization of hospital services during prolonged stays, as shown in Meehan2000 (Meehan K

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13

Rayment, Rachel, Nick Willcox, David Roberts, et al. "Mapping of Helper Epitopes to HPA-1a in Neonatal Alloimmune Thrombocytopenia with T-Cell Clones." Blood 112, no. 11 (2008): 3040. http://dx.doi.org/10.1182/blood.v112.11.3040.3040.

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Abstract Background: The major cause of severe neonatal allo-immune thrombocytopenia (NAITP) in Caucasians is fetal-maternal incompatibility for the human platelet antigen-1 (HPA-1), which is determined by the dimorphism Leu (HPA-1a) or Pro (HPA-1b) at amino acid position 33 of β3 integrin glycoprotein IIIa. Maternal responsiveness to HPA-1a shows a very strong association with DR52a (DRB3*0101) and 33Leu is thought to create a binding motif for this MHC class II molecule, thereby conferring helper T-cell responsiveness. At present, there are no preventative measures, reliable predictors of se

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Zhang, Nanyan, and Peter Newman. "Generation of iPSC-Derived Human Megakaryocytes for Flow Cytometric Detection of Platelet-Specific Alloantibodies." Blood 132, Supplement 1 (2018): 740. http://dx.doi.org/10.1182/blood-2018-99-111594.

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Abstract Antibodies that form against human platelet alloantigens (HPAs) are responsible for several clinically important alloimmune bleeding disorders, including fetal and neonatal alloimmune thrombocytopenia, posttransfusion purpura, and multitransfusion platelet refractoriness. Some of HPAs are relatively rare in the population, and difficult to obtain for purposes of transfusion therapy and diagnostic testing. In addition, HPA alloantisera often contain antibodies against human leucocyte antigen (HLA) class I, thereby limiting antibody detection to glycoprotein (GP)-specific assays such as

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15

Choi, Jun Young, and Jin Soo Suh. "Radiographic Measurements on Hindfoot Alignment View in 1,128 Asymptomatic Subjects." Foot & Ankle Orthopaedics 5, no. 4 (2020): 2473011420S0016. http://dx.doi.org/10.1177/2473011420s00166.

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Category: Hindfoot Introduction/Purpose: The primary aim of this study was to calculate the mean values of three most frequently measured parameters for hindfoot alignment determination in asymptomatic subjects - hindfoot alignment angle (HAA), hindfoot alignment ratio (HAR), and hindfoot moment arm (HMA). The secondary aim was to determine the relationship between HAR and HAA or HMA using statistical methods. Methods: From January 2014 to June 2019, a total of 1128 asymptomatic subjects were enrolled in this study. With the hindfoot alignment view by Saltzman and el-Khoury, HAA, HAR, and HMA

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Karwiński, A., R. Haratym, and R. Biernacki. "Accuracy of Ceramic Mould Filling with Liquid AlSi9 Aluminium Alloy in the Process Using Back-Pressure." Archives of Foundry Engineering 13, no. 1 (2013): 73–76. http://dx.doi.org/10.2478/afe-2013-0014.

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Abstract The paper presents the effect of suction pressure exerted on the liquid AlSi alloy when it is introduced into a ceramic mould made in the investment process and the results compared with data obtained on gravity poured castings. The study used special pattern sets and ceramic moulds made with the alternately applied soluble silicate binder and ethyl silicate. Additionally, self-supported moulds based entirely on the Ekosil binder were used. In the analysis of castings, the following parameters were examined: a linear dimensional accuracy, the state of surface microgeometry and the pos

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Ito, Sadayuki, Hiroaki Nakashima, Kei Ando, et al. "Human Nonmercaptalbumin Is a New Biomarker of Motor Function." Journal of Clinical Medicine 10, no. 11 (2021): 2464. http://dx.doi.org/10.3390/jcm10112464.

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The ratio of human nonmercaptalbumin (HNA) and reduced albumin (HMA) may be a new marker for oxidative stress. Locomotive syndrome (LS) is reduced mobility due to impairment of locomotive organs. We investigated whether the HNA/HMA ratio could be a new biomarker of LS. This study included 306 subjects (mean age 64.24 ± 10.4 years) who underwent LS tests, grip strength, walking speed, and tests for HNA and HMA. Oxidative stress was measured by the ratio of HMA (f(HMA) = (HMA/(HMA + HNA) × 100)), and the subjects were divided into normal (N group; f[HMA] ≥ 70%) and low (L group; f[HMA] < 70%)

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Lopes, Larissa Barbosa, Samira Ali Abbas, Elyse Moritz, et al. "Neonatal Alloimmune Neutropenia Due to Maternal Alloimmunization Against Human Neutrophil Alloantigen-1 and -3." Blood 124, no. 21 (2014): 4948. http://dx.doi.org/10.1182/blood.v124.21.4948.4948.

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Abstract Introduction: Neonatal alloimmune neutropenia (NAN) is a potentially lethal disorder that results from maternal alloimmunization to human neutrophil antigens (HNAs) present in the fetus. The alloantibodies more frequently involved in NAN are against the HNA-1 and -2 systems; however HNA-3, HNA-4 and HNA-5 systems have also been associated with cases of NAN. In this study we examined the frequency of neonatal neutropenia and investigated the presence of maternal anti-HNA-1, anti-HNA-3 and anti-HLA alloantibodies when neonatal neutropenia and maternal-fetal incompatibility to HNA-1 and

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Katagiri, Takamasa, Aiko Sato-Otsubo, Koichi Kashiwase, et al. "Frequent Loss of HLA Alleles From Hematopoietic Stem Cells in Patients with Hepatitis-Associated Aplastic Anemia." Blood 118, no. 21 (2011): 2407. http://dx.doi.org/10.1182/blood.v118.21.2407.2407.

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Abstract Abstract 2407 Background: Hepatitis-associated aplastic anemia (HAA), a subset of acquired AA which accounts for 5% of all AA, is thought to have an immune-mediated pathogenesis. Although the attack by CD8+ T cells may be responsible for both hepatitis and bone marrow failure, the exact mechanisms underlying the development of HAA, as well as the reason for the time lag from its onset to that of hepatitis remain unclear. We recently found HLA-class I allelic loss from leukocytes due to copy-number neutral LOH in chromosome 6p (6pLOH) in 15% of AA patients, and identified four class I

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Bonstein, Lilach, Nardeen Atweh, Nuhad Haddad, and Yariv Fruchtman. "Anti-HLA Antibodies in Neonatal Alloimmune Thrombocytopenia - Is There Any Clinical Significance?" Blood 126, no. 23 (2015): 4647. http://dx.doi.org/10.1182/blood.v126.23.4647.4647.

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Abstract Background: Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal alloantibodies raised against paternally inherited alloantigens carried on fetal platelets. Platelets express both HLA class I and specific human platelet antigens (HPA). Although anti-HLA class I antibodies are often detectable in pregnant women, NAIT is considered to be mainly associated with antibodies against HPA. Cases where NAIT has been caused by antibodies against HLA class I are relatively rare and the role of these antibodies in NAIT remains debatable. We hereby describe a sample case of NAIT prove

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Garraud, Olivier, Fabrice Cognasse, and Pierre Moncharmont. "Immunological Features in the Process of Blood Platelet-Induced Alloimmunisation, with a Focus on Platelet Component Transfusion." Diseases 7, no. 1 (2019): 7. http://dx.doi.org/10.3390/diseases7010007.

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Alloimmunisation to platelet antigens is not uncommon; a large number of females, having had pregnancies, developed antibodies to Human Leukocyte Antigen (HLA) moieties harboured on their foetuses’ cells (inherited from the father(s)) that may conflict with further pregnancies and transfused Platelet Components occasionally. This is possible since platelets constitutionally express HLA class I molecules (though in copy numbers that consistently differ among individuals). Platelets also express HPA moieties that are variants of naturally expressed adhesion and aggregation molecules; HPA differe

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Gulmira Zharmakhanova, Gulmira Zharmakhanova, Victoria Kononetc Victoria Kononetc, Lyazzat Syrlybayeva Lyazzat Syrlybayeva, Eleonora Nurbaulina Eleonora Nurbaulina, and Lyazzat Baikadamova Lyazzat Baikadamova. "HYPERPHENYLALANINEMIA: CASE REPORT." Ambiance in Life International Scientific Journal in Medicine of Southern Caucasus 06, no. 01 (2021): 96–97. http://dx.doi.org/10.36962/0601202196.

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Background: Hyperphenylalaninemia (HPA) is a group of autosomal recessive diseases caused by impaired metabolism of the essential amino acid phenylalanine (Phe), which enters the human body with protein food [1]. HFA combines several genetically heterogeneous forms of phenylalanine metabolism disorders similar in clinical features: classical phenylketonuria (PKU), caused by phenylalanine-4-hydroxylase (PAH) deficiency and hyperphenylalaninemia (HPA), associated with tetrahydrobiopterin (BH4) metabolic disorders [2]. The pterin-dependent form of hyperphenylalaninemia accounts for about 2% of al

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Silva, Anisia J., Kim Pham, and Jorge A. Benitez. "Haemagglutinin/protease expression and mucin gel penetration in El Tor biotype Vibrio cholerae." Microbiology 149, no. 7 (2003): 1883–91. http://dx.doi.org/10.1099/mic.0.26086-0.

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Vibrio cholerae of both biotypes produce a soluble Zn2+-dependent metalloprotease: haemagglutinin/protease (Hap), encoded by hapA. Hap has been shown to have mucinolytic and cytotoxic activity. These activities are likely to play an important role in the pathogenesis of cholera and the reactogenicity of attenuated vaccine strains. Production of Hap requires transcriptional activation by the HapR regulator and is repressed by glucose. The present study shows that mucin purified from two sources, bile salts, and growth at 37 °C enhanced Hap protease production. Analysis of hapA and hapR promoter

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KHASPEKOVA, S. G., L. L. GOLOVKINA, E. K. DONUSH, N. V. GOLUBEVA, O. N. SHUSTOVA, and A. V. MAZUROV. "Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia." Terapevticheskii arkhiv 90, no. 7 (2018): 65–69. http://dx.doi.org/10.26442/terarkh201890765-69.

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The aim. Mechanisms underlying the development of neonatal alloimmune thrombocytopenia (NAIT) in in Russia have been studied. Materials and methods. Genetic polymorphisms of human platelet alloantigens (HPA) -1, -2, -3, -4, -5, and -15 were evaluated in 27 families having the newborns with NAIT. NAIT was diagnosed according to the following criteria: (1) newborn with thrombocytopenia; (2) mother with no thrombocytopenia and no increase of platelet associated IgG, (3) presence of antibodies reacting with paternal platelets in maternal plasma / serum. HPA genotyping revealed incompatibilities in

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Hostettler, Isabel Charlotte, Matthew J. Morton, Gareth Ambler, et al. "Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage." Journal of Neurology, Neurosurgery & Psychiatry 91, no. 3 (2020): 298–304. http://dx.doi.org/10.1136/jnnp-2019-321774.

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ObjectiveHaptoglobin is a haemoglobin-scavenging protein that binds and neutralises free haemoglobin and modulates inflammation and endothelial progenitor cell function. A HP gene copy number variation (CNV) generates HP1 and HP2 alleles, while the single-nucleotide polymorphism rs2000999 influences their levels. The HP1 allele is hypothesised to improve outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH). We investigated the associations of the HP CNV genotype and rs2000999 with haematoma volume, perihaematomal oedema (PHO) volume, functional outcome and mortality after

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Honda, Shinji, Vincent T. Bicocca, Jordan D. Gessaman, et al. "Dual chromatin recognition by the histone deacetylase complex HCHC is required for proper DNA methylation in Neurospora crassa." Proceedings of the National Academy of Sciences 113, no. 41 (2016): E6135—E6144. http://dx.doi.org/10.1073/pnas.1614279113.

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DNA methylation, heterochromatin protein 1 (HP1), histone H3 lysine 9 (H3K9) methylation, histone deacetylation, and highly repeated sequences are prototypical heterochromatic features, but their interrelationships are not fully understood. Prior work showed that H3K9 methylation directs DNA methylation and histone deacetylation via HP1 in Neurospora crassa and that the histone deacetylase complex HCHC is required for proper DNA methylation. The complex consists of the chromodomain proteins HP1 and chromodomain protein 2 (CDP-2), the histone deacetylase HDA-1, and the AT-hook motif protein CDP

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Adam, Emma K., Jonathan M. Sutton, Leah D. Doane, and Susan Mineka. "Incorporating hypothalamic–pituitary–adrenal axis measures into preventive interventions for adolescent depression: Are we there yet?" Development and Psychopathology 20, no. 3 (2008): 975–1001. http://dx.doi.org/10.1017/s0954579408000461.

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AbstractAltered functioning of the hypothalamic–pituitary–adrenal (HPA) axis is a robust correlate of major depression in adults, and to a lesser extent, in adolescents. Premorbid differences in HPA axis function have been found to prospectively predict the onset of adolescent depression. To what extent might our knowledge of HPA axis function in adolescents with, or at risk for, depression, help guide efforts to prevent depression in this age group? We review evidence regarding the role of the HPA axis in the development of adolescent depression, and examine whether and which HPA axis measure

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Muvhali, Pfunzo, Maud Bonato, Anel Engelbrecht, et al. "The Effect of Extensive Human Presence at an Early Age on Stress Responses and Reactivity of Juvenile Ostriches towards Humans." Animals 8, no. 10 (2018): 175. http://dx.doi.org/10.3390/ani8100175.

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The effect of extensive human presence and regular gentle handling performed at an early age (0–3 months old) on stress responses and reactivity of juvenile ostriches towards humans was investigated. A total of 416 ostrich chicks over two years were exposed to one of three treatments for three months after hatching; namely, Human Presence 1 (HP1, N = 144): extensive/prolonged human presence with physical contact (touch, stroking), gentle human voice, and visual stimuli; Human Presence 2 (HP2, N = 136): extensive/prolonged human presence without physical contact, but with gentle human voice and

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Bonstein, Lilach, Roy Lauterbach, and Nuhad Haddad. "High Incidence of Alloimmunization to Platelets and Platelet Transfusion Refractoriness during Induction Therapy in Patients Diagnosed with Acute Myeloid Leukemia." Blood 126, no. 23 (2015): 3484. http://dx.doi.org/10.1182/blood.v126.23.3484.3484.

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Abstract Introduction: Patients with acute myeloid leukemia (AML) are treated with intensive chemotherapeutic protocols. They are known to suffer from protracted pancytopenia and need prolonged transfusion support. Despite the administration of leukocyte-reduced and irradiated blood products, long-term transfusion dependency predisposes these patients to alloimmunization to both leukocyte (HLA) and platelet (HPA) antigens, leading to immune platelet transfusion refractoriness, which is a major risk factor for bleeding-associated morbidity and mortality, to longer hospitalizations and higher in

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Mourilhe, P., P. E. Stokes, B. Lasley, et al. "HPA response to ECT as a function of age and basal HPA activity." Biological Psychiatry 37, no. 9 (1995): 613. http://dx.doi.org/10.1016/0006-3223(95)94487-h.

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Meijer, O. C., B. Topic, P. J. Steenbergen, G. Jocham, J. P. Huston, and M. S. Oitzl. "Correlations between Hypothalamus-Pituitary-Adrenal Axis Parameters Depend on Age and Learning Capacity." Endocrinology 146, no. 3 (2005): 1372–81. http://dx.doi.org/10.1210/en.2004-0416.

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Glucocorticoid hormones are released after activation of the hypothalamus-pituitary-adrenal (HPA) axis and in the brain can modulate synaptic plasticity and memory formation. Clear individual differences in spatial learning and memory in the water maze allowed classification of groups of young (3 months) and aged (24 months) male Wistar rats as superior and inferior learners. We tested 1) whether measures of HPA activity are associated with cognitive functions and aging and 2) whether correlations of these measures depend on age and learning performance. Basal ACTH, but not corticosterone, was

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Gassant, Pascale Yola, Marie Immacula Fleury, Genara Santana, et al. "#44: Hand Hygiene during the COVID-19 Pandemic in Three Pediatric Oncology Units in Hispaniola Island." Journal of the Pediatric Infectious Diseases Society 10, Supplement_2 (2021): S20. http://dx.doi.org/10.1093/jpids/piab031.048.

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Abstract Background Hand hygiene (HH) is a basic measure to prevent the spread of infections in healthcare settings. We describe HH practices and resources in three pediatric oncology units (POUs) in Haiti and the Dominican Republic that comprise the Hispaniola Project (HP1: Santiago; HP2: Santo Domingo; HP3: Port-au-Prince). This project, started in January 2019, is a quality improvement initiative in infection care and prevention in pediatric oncology. The POUs are main referral centers for pediatric oncology on the island, HP1 (24 inpatient beds) and HP2 (18 beds) are housed within large pu

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Heinselman, Pamela L., and Alexander V. Ryzhkov. "Validation of Polarimetric Hail Detection." Weather and Forecasting 21, no. 5 (2006): 839–50. http://dx.doi.org/10.1175/waf956.1.

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Abstract This study describes, illustrates, and validates hail detection by a simplified version of the National Severe Storms Laboratory’s fuzzy logic polarimetric hydrometeor classification algorithm (HCA). The HCA uses four radar variables: reflectivity, differential reflectivity, cross-correlation coefficient, and “reflectivity texture” to classify echoes as rain mixed with hail, ground clutter–anomalous propagation, biological scatterers (insects, birds, and bats), big drops, light rain, moderate rain, and heavy rain. Diagnostic capabilities of HCA, such as detection of hail, are illustra

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Greene, M. R., Z. Szczepiorkowski, and K. R. Meehan. "Non-myeloablative peripheral blood stem cell transplant in a patient with platelet (HPA) mismatch and pre-existing anti-donor platelet alloantibodies." Journal of Clinical Oncology 25, no. 18_suppl (2007): 17541. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.17541.

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17541 Background: Platelets display a series of polymorphic epitopes which are known as the human platelet alloantigen (HPA) system. Alloantibodies directed against these HPA epitopes cause platelet destruction resulting in thrombocytopenia and refractoriness to platelet transfusions. We describe the rare and unique clinical course of a 61 year old patient with relapsed Non-Hodgkin’s lymphoma (NHL) who received an HLA matched, sibling, non-myeloablative, peripheral blood stem cell transplant (PBSCT) who had alloantibodies directed against a mismatched donor HPA antigen prior to transplant. Met

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Sasaki, Takahiko, Kelsey L. Lynch, Caitlin V. Mueller, Steven Friedman, Michael Freitag та Zachary A. Lewis. "Heterochromatin Controls γH2A Localization in Neurospora crassa". Eukaryotic Cell 13, № 8 (2014): 990–1000. http://dx.doi.org/10.1128/ec.00117-14.

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ABSTRACTIn response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine. The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote DNA double-strand-break repair. To identify genomic loci that might be prone to replication fork stalling or DNA breakage inNeurospora crassa, we performed chromatin immunoprecipitation (ChIP) of γH2A followed by next-generation sequencing (ChIP-seq). γH2A-containing nucleosomes are enriched inNeurosporaheterochromatin domains. These

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Williams, Bryan J., Miriam Golomb, Thomas Phillips, Joshua Brownlee, Maynard V. Olson, and Arnold L. Smith. "Bacteriophage HP2 of Haemophilus influenzae." Journal of Bacteriology 184, no. 24 (2002): 6893–905. http://dx.doi.org/10.1128/jb.184.24.6893-6905.2002.

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ABSTRACT Temperate bacteriophages effect chromosomal evolution of their bacterial hosts, mediating rearrangements and the acquisition of novel genes from other taxa. Although the Haemophilus influenzae genome shows evidence of past phage-mediated lateral transfer, the phages presumed responsible have not been identified. To date, six different H. influenzae phages are known; of these, only the HP1/S2 group, which lyosogenizes exclusively Rd strains (which were originally encapsulated serotype d), is well characterized. Phages in this group are genetically very similar, with a highly conserved

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Rajasagi, Mohini, Sachet A. Shukla, Edward F. Fritsch, et al. "Tumor Neoantigens Are Abundant Across Cancers." Blood 122, no. 21 (2013): 3265. http://dx.doi.org/10.1182/blood.v122.21.3265.3265.

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Abstract Tumor neoantigens are a promising class of vaccine immunogens as they arise from gene alterations in tumor cells and are hence exquisitely tumor-specific. We recently reported the development of a pipeline that leverages massively parallel sequencing data with HLA-peptide binding predictions to identify candidate neoantigens. By applying this pipeline to cases of chronic lymphocytic leukemia (CLL) with known HLA typing, we described the prediction of personal tumor neoantigens against which long-lived memory T cell responses developed following remission-inducing therapy. Our pipeline

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Lopes, Larissa Barbosa, Samira Ali Abbas, Wilson Baleotti, et al. "A Serologic and Molecular Study of the HNA-3 System-Associated Neonatal Neutropenia." Blood 118, no. 21 (2011): 2168. http://dx.doi.org/10.1182/blood.v118.21.2168.2168.

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Abstract Abstract 2168 Background: Neonatal alloimmune neutropenia (NAN) is a potentially lethal disorder that results of maternal alloimmunization to fetal human neutrophil antigens (HNAs). The alloantibodies more frequently involved in NAN are directed against the HNA-1 and -2 systems, however anti-HNA-3 has also been associated with cases of NAN. Therefore, in this study we investigated the presence of maternal anti-HNA-3 antibodies in HNA-3 allele genotypic maternal-fetal incompatibility cases of neonatal neutropenia. Material and Methods: A cross sectional study included samples from 10,0

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Carvalho, Laura M. L., Cláudia N. Ferreira, Daisy K. D. de Oliveira, et al. "Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome." Journal of Assisted Reproduction and Genetics 34, no. 12 (2017): 1691–98. http://dx.doi.org/10.1007/s10815-017-1030-3.

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Gafarov, V. V., E. A. Gromova, D. O. Panov, et al. "15-year risk of developing type 2 diabetes mellitus and its relationship with personal anxiety, sleep disturbance among men 45-69 years old in Russia /Siberia (international epidemiological study “HAPIEE”)." Diabetes mellitus 23, no. 3 (2020): 204–9. http://dx.doi.org/10.14341/dm10073.

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BACKGROUND:Determine the effect of personal anxiety, sleep disorders on the 15-year risk of developing (RR) diabetes mellitus (DM) type 2 among men (M) 45-69 years in Russia / Siberia (Novosibirsk). METHODS:In 20032005 As part of the IV screening of the international epidemiological study HAPIEE, a representative sample of m 4569 years was examined (n=781 M, mean age-56.480.20 years, response 61.00%). The level of personal anxiety (PA) was assessed using the Spielberger scale (HPA high, MPA medium, LPA low). With the help of the scale Knowledge and attitude to ones health, the level of s

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Kaller, Markus, Ursula Euteneuer, and Wolfgang Nellen. "Differential Effects of Heterochromatin Protein 1 Isoforms on Mitotic Chromosome Distribution and Growth in Dictyostelium discoideum." Eukaryotic Cell 5, no. 3 (2006): 530–43. http://dx.doi.org/10.1128/ec.5.3.530-543.2006.

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ABSTRACT Heterochromatin protein 1 (HP1) is a well-characterized heterochromatin component conserved from fission yeast to humans. We identified three HP1-like genes (hcpA, hcpB, and hcpC) in the Dictyostelium discoideum genome. Two of these (hcpA and hcpB) are expressed, and the proteins colocalized as green fluorescent protein (GFP) fusion proteins in one major cluster at the nuclear periphery that was also characterized by histone H3 lysine 9 dimethylation, a histone modification so far not described for Dictyostelium. The data strongly suggest that this cluster represents the centromeres.

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Lazalde, Brissia, Héctor M. Huerta-Guerrero, Luis E. Simental-Mendía, Martha Rodríguez-Morán та Fernando Guerrero-Romero. "Haptoglobin 2-2 Genotype Is Associated with TNF-αand IL-6 Levels in Subjects with Obesity". Disease Markers 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/912756.

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Objective. To evaluate the association between Haptoglobin (HP) gene polymorphisms with inflammatory status in obese subjects.Materials and Methods. A cross-sectional study was carried out. A total of 276 apparently healthy men and nonpregnant obese women were enrolled and allocated according to theHPgenotype into theHP1/HP1,HP2/HP1, andHP2/HP2groups. Distribution ofHPgenotypes was 49, 87, and 140 for theHP1/HP1,HP2/HP1, andHP2/HP2, respectively. TheHPgenotype was determined using the polymerase chain reaction method. A multiple linear regression analysis adjusted by age, sex, waist circumfere

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Bora, Komal, Kavita Natarajan, Ferdane Kutlar, et al. "In Vitro Exploratory Studies of Haptoglobin Polymorphisms and Their Effect on Cytokine Release from Cultured Mononuclear Cells in Sickle Cell Disease." Blood 112, no. 11 (2008): 1441. http://dx.doi.org/10.1182/blood.v112.11.1441.1441.

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Abstract The deleterious effects of hemolysis through its end product cell free hemoglobin(Hb) as a nitric oxide (NO) scavenger is well established and has been incriminated in the pathogenesis of some complications of SCD such as pulmonary hypertension, leg ulcers, renal dysfunction, and possibly stroke. These observations have led some investigators to hypothesize that these complications form a subphenotype of SCD related predominantly to hemolysis and endothelial dysfunction. In hemolytic states Hb released from RBC complexes with Haptoglobin (Hp) and is removed from the circulation by mac

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Kim, Samin, Dindo Reyes, Marie Beaume, Patrice Francois, and Ambrose Cheung. "Contribution of teg49 Small RNA in the 5′ Upstream Transcriptional Region ofsarAto Virulence in Staphylococcus aureus." Infection and Immunity 82, no. 10 (2014): 4369–79. http://dx.doi.org/10.1128/iai.02002-14.

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ABSTRACTHigh-throughput RNA sequencing technology has found the 5′ untranslated region ofsarAto contain two putative small RNAs (sRNAs), designated teg49 and teg48. Northern blot analysis disclosed that teg49 and teg48 were detectable within the P3-P1 and P1sarApromoter regions, respectively. Focusing on teg49, we found that this sRNA, consisting of 196 nucleotides, is transcribed in the same direction as thesarAP3 transcript. The expression of both P3 and teg49 transcripts is dependent onsigBandcshA, which encodes a DEAD box RNA helicase. Within the sRNA teg49, there are two putative hairpin-

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Sheng, Julietta A., Ashley L. Heck, Alex M. Miller, et al. "Age and Parity Effects in the Hypothalamic Pituitary Adrenal Axis’ Response to Multimodal Stress in Female Mice." Journal of the Endocrine Society 5, Supplement_1 (2021): A531—A532. http://dx.doi.org/10.1210/jendso/bvab048.1082.

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Abstract The hypothalamic pituitary adrenal (HPA) axis responds to environmental perturbations to maintain homeostasis. Pregnancy demands extensive modifications in HPA axis function to prepare for increased energy and metabolic demands required to meet the needs of mother and offspring. Short-term effects of pregnancy on the HPA axis have been shown, but data is lacking regarding the long-term effects in middle-aged female mice no longer breeding. Since changes of the HPA axis are further found with age, in this study, we examined both parity- and age-related interactions on the HPA axis in f

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Perry, Rachel J., Jon M. Resch, Amelia M. Douglass, et al. "Leptin’s hunger-suppressing effects are mediated by the hypothalamic–pituitary–adrenocortical axis in rodents." Proceedings of the National Academy of Sciences 116, no. 27 (2019): 13670–79. http://dx.doi.org/10.1073/pnas.1901795116.

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Leptin informs the brain about sufficiency of fuel stores. When insufficient, leptin levels fall, triggering compensatory increases in appetite. Falling leptin is first sensed by hypothalamic neurons, which then initiate adaptive responses. With regard to hunger, it is thought that leptin-sensing neurons work entirely via circuits within the central nervous system (CNS). Very unexpectedly, however, we now show this is not the case. Instead, stimulation of hunger requires an intervening endocrine step, namely activation of the hypothalamic–pituitary–adrenocortical (HPA) axis. Increased corticos

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Wallace, Jacqueline M., John S. Milne, Lucy R. Green, and Raymond P. Aitken. "Postnatal hypothalamic - pituitary - adrenal function in sheep is influenced by age and sex, but not by prenatal growth restriction." Reproduction, Fertility and Development 23, no. 2 (2011): 275. http://dx.doi.org/10.1071/rd10103.

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The relationship between impaired fetal nutrient supply and postnatal hypothalamic–pituitary–adrenal (HPA) function was examined in ovine models of prenatal growth restriction (GR) caused by small placental size (SP) or by maternal undernutrition (UN). Adrenocorticotrophin (ACTH) and cortisol responses following corticotrophin-releasing hormone (CRH) plus arginine vasopressin (AVP) challenge were examined at 9, 18 and 24 months in growth-restricted (GR-SP) and normal birthweight (control) females (Experiment 1), and at 6 months in growth-restricted (GR-SP, GR-UN) and normal weight males and fe

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Han, Yun, and Su Ting Ma. "The Relationship between THMFP and the Variation of Fluorescence Characteristic of DOM among the Different Bio-Treatment Processes." Advanced Materials Research 356-360 (October 2011): 2042–46. http://dx.doi.org/10.4028/www.scientific.net/amr.356-360.2042.

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Dissolved organic matter (DOM) from different biological treated wastewater in secondary effluent of different municipal wastewater treated plants are isolated and fractionated using resin adsorption into five different fractions: hydrophobic bases (HOB), hydrophobic acids (HOA), hydrophilic bases (HIB), hydrophilic acids (HIA) and hydrophilic neutrals (HIN). The characteristics of three dimensional excitation emission matrix fluorescence spectroscopy (3DEEM) and disinfection by-products formation potential (THMFP) of each fraction are investigated. The objective of this study is to investigat

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Et al., Bazla Mukhtar. "Cognitive Age and Consumption Pattern among Aging Population - Moderating Impact of Self Confidence and Social Involvement." Psychology and Education Journal 58, no. 1 (2021): 1859–70. http://dx.doi.org/10.17762/pae.v58i1.1041.

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Pakistan has become one of the exciting markets for marketers due to the paradigm shift of the market, reduced regulation, and privatization of several enterprises. Despite several research studies on consumer behaviors, few researchers have studied the change in elderly consumers' choices and their behavior in the rapidly changing market. Therefore, this research investigates the influence of cognitive age on loyalty proneness, status consumption, and materialism level for Pakistani elders. It evaluates if social involvement and self-confidence can moderate these relationships. Elderly consum

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Wang, Yanping, Ella R. Rotman, Nadja B. Shoemaker, and Abigail A. Salyers. "Translational Control of Tetracycline Resistance and Conjugation in the Bacteroides Conjugative Transposon CTnDOT." Journal of Bacteriology 187, no. 8 (2005): 2673–80. http://dx.doi.org/10.1128/jb.187.8.2673-2680.2005.

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ABSTRACT The tetQ-rteA-rteB operon of the Bacteroides conjugative transposon CTnDOT is responsible for tetracycline control of the excision and transfer of CTnDOT. Previous studies revealed that tetracycline control of this operon occurred at the translational level and involved a hairpin structure located within the 130-base leader sequence that lies between the promoter of tetQ and the start codon of the gene. This hairpin structure is formed by two sequences, designated Hp1 and Hp8. Hp8 contains the ribosome binding site for tetQ. Examination of the leader region sequence revealed three seq

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