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Dissertations / Theses on the topic 'Benzodiazepines'

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1

Rizzo, Michael L. "The Prescribing Knowledge, Attitudes, and Practices among Nurse Practitioners in Maine towards Benzodiazepines." Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/RizzoML2004.pdf.

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2

Riond, Joëlle. "Benzodiazepines peripheriques." Lyon, INSA, 1990. http://www.theses.fr/1990ISAL0094.

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Les benzodiazépines sont sédatives, anxiolytiques et anti-convulsantes. Leurs s'exercent par l'intermédiaire de récepteurs dans le système nerveux central. Cependant, certaines benzodiazépines se fixent aussi sur un récepteur pharmacologiquement distinct (BPBS), dans les organes périphériques. Celui-ci semble être impliqué dans l'immuno-modulation : nous avons observé un effet des benzodiazépines périphériques sur la prolifération lymphocytaire in vitro. Afin de caractériser le récepteur de ces ligands, nous l'avons purifié à partir de la l ignée cellulaire CHO (hamster), puis clivé, pour en d
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3

Bentes, Ana Paula Guerreiro 1985. "Estudo comparativo dos efeitos do alprazolam e midazolam no controle da ansiedade em implantodontia." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290773.

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Orientador: Eduardo Dias de Andrade<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-20T06:28:38Z (GMT). No. of bitstreams: 1 Bentes_AnaPaulaGuerreiro_M.pdf: 1168135 bytes, checksum: ca31fffb62b345249aeec51b5df67d0c (MD5) Previous issue date: 2012<br>Resumo: A sedação mínima deve ser considerada como parte do protocolo farmacológico nas cirurgias implantodônticas, já que os pacientes podem apresentar um grau aumentado de ansiedade, interrompendo o curso da intervenção, entre outras possíveis intercorr
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4

SEROR, PAULE-MICHELE. "Les antagonistes des benzodiazepines." Lyon 1, 1989. http://www.theses.fr/1989LYO1M257.

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5

DEFOUR, ERIC. "Reactions cutanees aux benzodiazepines." Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR1M132.

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6

NICOLAI, LAURENT. "Effets amnesiants des benzodiazepines." Strasbourg 1, 1992. http://www.theses.fr/1992STR15003.

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7

Guenoux, Charles-Albert. "Benzodiazepines : aspects pharmacologiques actuels." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20952.

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8

MOUSSY, HUBERT CORINNE. "Etudes psychometriques des benzodiazepines." Nantes, 1992. http://www.theses.fr/1992NANT042M.

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9

Braun, Ivan Mario. "Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/.

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INTRODUÇÃO: O midazolam é uma imidazobenzodiazepina usada para induzir o sono, produzir sedação antes de procedimentos dolorosos e no tratamento do estado de mal epiléptico. Seu uso pela via intranasal proporciona um rápido início de ação e esta via, em muitos casos, pode substituir as vias endovenosa e intramuscular, mais invasivas. Assim, o midazolam intranasal tem sido sugerido no tratamento extra-hospitalar de crises epilépticas e ataques de pânico. Por outro lado, os benzodiazepínicos possuem um potencial para serem abusados, principalmente em usuários de outras drogas. OBJETIVO: o presen
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10

STITI, SALADIN. "Les benzodiazepines et leurs paradoxes." Toulouse 3, 1988. http://www.theses.fr/1988TOU31061.

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11

COISSARD, ANNE-NADINE. "Benzodiazepines et grossesse : complications neonatales." Lyon 1, 1993. http://www.theses.fr/1993LYO1M193.

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12

MALOGNE, HERVE. "La toxicite hepatique des benzodiazepines." Amiens, 1993. http://www.theses.fr/1993AMIEM013.

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13

NEYMEYER, NATHALIE. "Benzodiazepines et induction de l'anesthesie." Strasbourg 1, 1987. http://www.theses.fr/1987STR10709.

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14

NOEUVEGLISE, ERIC. "Embryofoetopathie par benzodiazepines : une entite ?" Lille 2, 1994. http://www.theses.fr/1994LIL2M100.

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15

GAGET, YVES. "Les hepatites dues aux benzodiazepines." Nice, 1992. http://www.theses.fr/1992NICE6535.

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16

Tancredi, Francisco Bernardini. "Consumo de medicamentos benzodiazepínicos no Brasil - 1970 a 1985: estudo comparativo de tendências." Universidade de São Paulo, 1986. http://www.teses.usp.br/teses/disponiveis/6/6135/tde-26072016-172521/.

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Um aspecto marcante do mercado brasileiro de medicamentos benzodiazepínicos é o largo emprego das associações medicamentosas de venda livre conhecidas genericamente como \"antidistônicos\". Sua composição só difere daquela dos ansiolíticos e hipnóticos de venda controlada pelo acréscimo de pequenas doses anticolinárgico e/ou antiespasmódico; as razões da ausência de controle sobre suas vendas são essencialmente não-médicas. Assim, quando se discute o consumo de benzodiazepínicos no Brasil, deve-se fazer distinçã entre os ansiolíticos e hipnóticos de venda livre ou controlada. No período de 197
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17

Duran, i. Hortalà Màrius. "Permeació transdèrmica d'una sèrie de benzodiazepines." Doctoral thesis, Universitat de Barcelona, 2002. http://hdl.handle.net/10803/1613.

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INTRODUCCIÓ: <br/><br/>Les benzodiazepines figuraren entre els grups terapèutics de més consum (en import) del Sistema Nacional de Salud de l'estat Espanyol durant els anys 1999 i 2000 (Ministerio Sanidad y Consumo, 2000; 2001).<br/>L'administració d'aquests fàrmacs a l'organisme es realitza majoritàriament per via oral. Una alternativa a la via oral, per a fàrmacs idònis, és la via transdèrmica. Els avenços en tecnologia farmacèutica han cristal·litzat en l'obtenció, per a determinats fàrmacs, de sistemes d'alliberament transdèrmic (SAT) coneguts amb el nom de pegats transdèrmics.<br/>Les car
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18

Wixson, Sarah E. "Medication misadventures: the case of benzodiazepines." UKnowledge, 2015. http://uknowledge.uky.edu/pharmacy_etds/49.

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For patients afflicted with symptoms of anxiety and insomnia, benzodiazepines are generally a safe and effective short-term pharmacological treatment option. Although considered safer than other sedative-hypnotic medications, substantial concern exists regarding the addictive nature and abuse potential of benzodiazepines along with potentially inappropriate prescribing and utilization in clinically vulnerable populations. These medication misadventures can have a significant impact on public health. Examples of medication misadventures as they pertain to benzodiazepines include the prescribing
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19

Richardson, Peter J. "Formulation of benzodiazepines for parenteral delivery." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334488.

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20

Fee, John Patrick Howard. "Pharmocokinetic and other studies with benzodiazepines." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335496.

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21

MacQuarrie, Stephanie Lee. "Design and Synthesis of Novel Benzodiazepines." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/30209.

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Bivalent drug design is an efficient strategy for increasing potency and selectivity of many drugs. We devised a strategy to prepare agonist-benzodiazepine heterodimers that could simultaneously bind to agonist and BZD sites of the GABAAR. We synthesized a benzodiazepine-MPEG model compound that relied on physiological GABA to elicit flux. We established that a tether at the N1 position of the BZD would not prevent binding to the receptor. However, coupling of GABA amides with long chain PEG tethers studied by another group member resulted in complete loss of agonist activity. We therefore cea
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22

Jonot, André. "Les benzodiazepines : usage, abus et intoxications." Université Louis Pasteur (Strasbourg) (1971-2008), 1990. http://www.theses.fr/1990STR1M117.

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23

Witt, Anette. "Synthetic development towards benzodiazepine alkaloids : total synthesis of circumdatin F and C /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-077-6/.

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24

Jones, Garry B. "Design, synthesis and evaluation of DNA-binding oxazolo[2,3-c][1,4]benzodiazepines and pyrrolo[2,1-c][1,4]benzodiazepines." Thesis, University of Portsmouth, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293269.

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25

Alyami, A. M. "Pharmacology of benzodiazepines and GABA in intestine." Thesis, University of Bradford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384251.

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26

BACHERT, BLANC CATHY. "Pharmacodependance aux benzodiazepines et syndrome de sevrage." Lille 2, 1991. http://www.theses.fr/1991LIL2P069.

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27

Chen, Andrew David. "ISOLATION AND IN VITRO CHARACTERIZATION OF MAMMALIAN CEREBRAL CORTICAL FACTORS INTERACTIVE WITH THE CENTRAL NERVOUS SYSTEM BENZODIAZEPINE RECEPTOR (ENDOGENOUS LIGANDS)." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275444.

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28

Wilson, Katherine. "Benzodiazepines for conscious sedation in paediatric dental patients." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419997.

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29

SUIRE, CHRISTIAN. "Etat de mal convulsif apres sevrage des benzodiazepines." Angers, 1991. http://www.theses.fr/1991ANGE1046.

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30

Billioti, de Gage Sophie. "Benzodiazepines and risk of dementia in the elderly." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0106/document.

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Ce travail porte sur l’étude du risque de démence chez les personnes âgées ayant consommé des benzodiazépines. Ces médicaments méritent une attention particulière du fait de (i) leur utilisation trop systématique et le plus souvent chronique contrairement aux recommandations préconisant des durées d’utilisation courtes (ii) leurs effets délétères sur la cognition demeurant mal évalués à long terme. La plupart des études conduites sur ce sujet ont conclu à une augmentation du risque de démence chez les sujets ayant utilisé des benzodiazépines. Un biais protopathique pouvait cependant, en partie
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31

Alenfall, Jan. "Peripheral benzodiazepine receptors in prostate and prostatic tumors characterization, hormonal regulation and possible role in tumorigenesis /." Lund : Dept. of Pharmacology, University of Lund, 1995. http://books.google.com/books?id=_xlrAAAAMAAJ.

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32

Xu, Zhiwen. "Topology characterization of a benzodiazepine-binding domain of GABAA receptor and anxiolytic-like effect of baicalin acting through the benzodiazepine-binding site /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?BICH%202005%20XUZ.

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Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2005.<br>On t.p. final "A" of GABAA is subscript. Includes bibliographical references (leaves 148-167). Also available in electronic version.
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33

Borel, Anthony Gerard Francis. "The metabolic profiling of clobazam in rats." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28921.

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Clobazam (CLBZ) is a 1,5-benzodiazepine with potent anticonvulsant activity. The metabolism of this drug was investigated in the rat and in vitro with the aid of stable isotope-labelled analogues and gas chromatography-mass spectroscopy (GCMS). Pentadeuteriophenyl CLBZ [²H₅]CLBZ was synthesized in essentially quantitative isotopic purity, and characterized by ¹H-NMR and GCMS. Of the five steps involved in the synthesis of [²H₅]CLBZ, the most susceptible to deuterium exchange was the nucleophilic substitution of 2,4-dichloronitrobenzene by aniline-d₇ to form N-(5-chloro-2-nitrophenyl)pentadeut
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34

Duerson, Kevin Collin 1958. "Subcellular distribution and binding characterization of the peripheral benzodiazepine receptor in the rat liver." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276794.

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The peripheral benzodiazepine receptor (PBZ) population in the rat liver has been kinetically and pharmacologically characterized. These data revealed a receptor with a dissociation constant (Kd) of 5.67 nM and a receptor density of 758 fmoles/ mg protein in a crude membrane preparation. Subcellular distribution studies demonstrated that PBZs were detected in highly purified nuclear, mitochondrial and microsomal fractions. Porphyrins were shown to interact at the PBZ with protoporphyrin IX and hemin having the highest affinity. Preliminary studies on the subnuclear distribution of PBZs are rep
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35

Holt, Robert Andrew. "The effect of benzodiazepines on GABA(A) receptor homeostasis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0003/NQ29049.pdf.

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36

Tenn, Catherine C. "Antidopaminergic effect of benzodiazepines and melatonin in rat striatum." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0018/NQ30175.pdf.

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37

BAUDOIN, PATRICE. "Apport des benzodiazepines dans le sevrage des toxicomanies opiacees." Angers, 1988. http://www.theses.fr/1988ANGE1106.

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38

BOTTLAENDER, MICHEL. "Physiopathologie et pharmacologie in vivo des recepteurs des benzodiazepines." Paris 11, 1994. http://www.theses.fr/1994PA112370.

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Les benzodiazepines sont des substances anxiolytiques, sedatives, anticonvulsivantes et myorelaxantes agissant par l'intermediaire d'un site de liaison specifique faisant partie du complexe recepteur gaba#a: le recepteur des benzodiazepines (rbz). Nous avons etudie differents aspects moleculaires du fonctionnement des rbz au sein du cerveau chez le sujet vivant. La tomographie par emission de positons a ete utilisee pour suivre, in vivo, la liaison cerebrale du #1#1cflumazenil (un radioligand specifique des rbz), dans differentes conditions experimentales: chez le primate infra-humain, nous av
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39

Potier, Marie-Claude. "Heterogeneite des recepteurs des benzodiazepines : etudes biochimiques et pharmacologiques." Paris 6, 1988. http://www.theses.fr/1988PA066488.

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Etude de molecules "hybrides" benzodiazepine-beta-carboline concues d'apres les modeles theoriques postulant l'existence de sites de liaison differents pour les benzodiazepines et les beta-carbolines sur un meme recepteur. Seules les molecules hybrides ayant a la fois les elements finis structuraux necessaires a la liaison des benzodiazepines et de beta-carbolines se lient aux recepteurs des benzodiazepines avec une forte affinite
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40

FAVRE, FLORENCE. "Syntheses de pyrrolo2,1-c 1,4 benzodiazepines apparentees a l'anthramycine." Paris 11, 1992. http://www.theses.fr/1992PA112430.

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Les pyrrolo 2,1-c 1,4 benzodiazepines sont des antibiotiques antitumoraux produits par divers streptomyces. Ces composes exercent leur activite antitumorale en alkylant l'adn par attaque nucleophile d'une guanine sur leur fonction imine ou imine potentielle en n-10-c-11. La configuration (s) du carbone en c-11a est necessaire pour l'alkylation. En synthese, cette configuration est obtenue par l'utilisation de l'acide (s) pyroglutamique comme precurseur. En effet, les derives (5s) n-orthonitrobenzoyl-5-hydroxymethyl-2-methoxypyrrolidines, intermediaires utilises anterieurement dans le laboratoi
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41

West, Robert E. 1952. "Confirmation of urinary benzodiazepines by gas chromatography/mass spectrometry." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/277228.

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A new method is described for the quantitative analysis of urinary benzodiazepines by gas chromatography/mass spectrometry. Development work was aimed at satisfying federal requirements for methods used in forensic urine drug testing which have become the standard in the laboratory industry. Trimethylsilyl (TMS), tert-butyl-dimethylsilyl (TBDMS) and benzophenone derivatives were tested in the development of the new assay. TBDMS derivatives were found to be the most suitable for the analysis of six common benzodiazepine metabolites. Precision for all metabolites tested, as measured by the withi
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42

Wiklund, Per. "Synthesis of heterocycles from anthranilic acid and its derivatives /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-913-7/.

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43

Wanderley, Thyago da Costa. "O uso de benzodiazepínicos em populações paraibanos: a influência das relações de parentesco." Universidade Estadual da Paraíba, 2014. http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2556.

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44

Roberts, Caroline Jane. "Development and application of enzyme-linked immunosorbent assays for the detection of drugs in the equine." Thesis, University of Sunderland, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338354.

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45

Mphahlele, Malose Jack. "Synthetic and spectroscopic studies of 1,4-benzodiazepine analogues." Thesis, Rhodes University, 1994. http://hdl.handle.net/10962/d1005049.

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In this project, an extensive range of benzodiazepine analogues have been synthesised via Schmidt reaction of specially prepared flavanone, 4-quinolone and l-thioflavanone precursors; nitrogen insertion being effected by use of trimethylsilyl azide in trifluoroacetic acid. In some cases, several of the benzodiazepine analogues have also been prepared by alternative cyclisation routes. A detailed kinetic-mechanistic study of the Schmidt reaction of flavanones has been carried out using 'H NMR spectroscopy to explain the observed regiochemistry of nitrogen insertion. The reaction rates, for the
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46

Whittal, R. D. "Synthetic and spectrometric investigation of 1,4-benzoxazepines." Thesis, Rhodes University, 1990. http://hdl.handle.net/10962/d1005046.

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Flavanone (2,3-dihydro-2-phenyl-4H-benzopyran-4-one) and a series of 4'- and 7-halogeno derivatives were prepared from the corresponding 2'-hydroxychalcones [1-(2-hydroxyphenyl)-3-phenyl-2-propen-l-ones], which, in turn, were synthesized by aldol condensation of substituted 2'-hydroxacetophenones with various benzaldehydes. A series of 2,3-dihydro-2-phenyl-l,4-benzoxazepin-5(4H)-ones were prepared by ring expansion of the corresponding flavanones, via the Schmidt reaction, using trimethylsilylazide and trifluoroacetic acid. A series of tetrazoles {2,3-dihydro-2-phenyl-tetrazolo[1,5-d]-1,4-benz
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47

Arnot, Michelle Ingrid. "Benzodiazepines and the GABA¦A receptor, effects of chronic exposure." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0023/NQ34729.pdf.

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48

Shimizu, Michael S. "Benzodiazepines as an adjunct in the management of postoperative pain." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0016/MQ49443.pdf.

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49

Adams, Lesley Jane. "Molecular modelling studies on the pyrrolo[2,1-c][1,4]benzodiazepines." Thesis, University of Portsmouth, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368744.

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50

Wright, Jacqueline Lee. "Pediatric Delirium in Mechanically Ventilated Patients and Use of Benzodiazepines." Mount St. Joseph University Dept. of Nursing / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=msjdn1618957346676197.

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