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1

Malm, Torsten. Absorbable patches in cardiac surgery: An experimental study. Uppsala Universitet, 1991.

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2

Nathalie, Virag, Blanc Olivier MS, and Kappenberger Lukas, eds. Computer simulation and experimental assessment of cardiac electrophysiology. Futura, 2001.

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3

Nathalie, Virag, Blanc Olivier MS, Kappenberger Lukas, and International Workshop on Computer Simulation and Experimental Assessment of Electrical Cardiac Function (2nd : 2000 : Lausanne, Switzerland), eds. Computer simulation and experimental assessment of cardiac electrophysiology. Futura Publishing Company, 2001.

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4

Pedersen, Hans Kristian. Electrolyte addition to nonionic contrast media: Cardiac effects during experimental coronary arteriography. Munksgaard, 1996.

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5

Green, Nicola Kim. Regulation of rat myocardial gene expression by thyroid status and in experimental models of cardiac hypertrophy. University of Birmingham, 1991.

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6

Forum, on Investigational and Experimental Modalities (1st 1990 Chicago Ill ). Proceedings of the Forum on Investigational and Experimental Modalities: Clinical applications of positron emission tomography to cardiac imaging, October 30-November 1, 1990. Health Insurance Association of America, 1991.

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7

Kamenskaya, Valentina, and Leonid Tomanov. The fractal-chaotic properties of cognitive processes: age. INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1053569.

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In the monograph the literature information about the nature of stochastic processes and their participation in the work of the brain and human behavior. Established that the real cognitive processes and mental functions associated with the procedural side of external events and the stochastic properties of the internal dynamics of brain systems in the form of fluctuations of their parameters, including cardiac rhythm generation and sensorimotor reactions. Experimentally proved that the dynamics of the measured physiological processes is in the range from chaotic regime to a weakly determinist
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8

L, Harwood John, and Walton T. J, eds. Plant membranes: Structure, assembly and function : a meeting organized by the Phytochemical Society of Europe, the Membrane Group of the Biochemical Society and the Plant Metabolism Group of the Society for Experimental Biology and held at University College Cardiff in April 1988. Biochemical Society, 1988.

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9

Greeff, K. Cardiac Glycosides : Part I: Experimental Pharmacology. Springer London, Limited, 2011.

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10

Greeff, Kurt. Cardiac Glycosides : Part I: Experimental Pharmacology. Springer, 2011.

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11

Nagano, Makoto, Naranjan S. Dhalla, and Bohuslav Ost'ádal. Cardiac Development (Progress in Experimental Cardiology). Springer, 2002.

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12

Jacob, Ruthard. Experimental Cardiac Hypertrophy and Heart Failure. Steinkopff, Dietrich, 2013.

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13

Greeff, Kurt. Cardiac Glycosides : Part I: Experimental Pharmacology. Springer, 2012.

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14

Aranega, A., and T. Pexieder. Correlations between experimental cardiac embryology and teratology and congenital cardiac defects. Editorial Universidad de Granada, 1989.

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15

(Editor), Pawan K. Singal, Ian M.C. Dixon (Editor), Lorrie A. Kirshenbaum (Editor), and Naranjan S. Dhalla (Editor), eds. Cardiac Remodeling and Failure (Progress in Experimental Cardiology). Springer, 2003.

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16

Blanc, Olivier, Dayi Hu, Shigeru Saito, Lukas Kappenberger, Thach Nguyen, and Lukas Kappenbberger. Computer Simulation and Experimental Assessment of Cardiac Electrophysiology. Blackwell Publishing Limited, 2001.

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17

Pepper, John. Cardioprotection During Cardiac Surgery. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199544769.003.0007.

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• Overall early mortality for cardiac surgery is low at 2–3% but in high risk patients it can be high as 10–15%• The demography of cardiac surgical patients is changing to older and sicker patients• Myocardial ischaemia-reperfusion injury and the systemic inflammatory response are closely related• Several pharmacological agents that have been demon-strated to confer cardioprotection in the experimental setting have been applied to the clinical setting of cardiac surgery. However, the transfer of these findings from the bench to the bedside has been largely disappointing• Potential cardioprotec
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18

(Editor), Naranjan S. Dhalla, Larry Hryshko (Editor), Elissavet Kardami (Editor), and Pawan K. Singal (Editor), eds. Signal Transduction and Cardiac Hypertrophy (Progress in Experimental Cardiology). Springer, 2003.

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19

Ruiz-Villalba, Adrián, Nikolaos Frangogiannis, and José Maria Pérez-Pomares. Origin and diversity of cardiac fibroblasts: developmental substrates of adult cardiac fibrosis. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0012.

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Cardiac connective tissues are primarily formed by cardiac fibroblasts (CF) of diverse embryonic origins. Whereas CF specific roles in cardiac morphogenesis remain under-researched, their involvement in adult cardiac fibrosis is clinically relevant. Cardiac fibrosis is a common element of several chronic cardiac conditions characterized by the loss of ventricular wall mechanical function, ultimately driving to heart failure. In the ischaemic heart early reparative fibrosis evidences the very restricted regenerative potential of the myocardium. In non-ischaemic diseases fibrosis is activated by
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20

(Editor), Robert Kass, and Colleen E. Clancy (Editor), eds. Basis and Treatment of Cardiac Arrhythmias (Handbook of Experimental Pharmacology) (Handbook of Experimental Pharmacology). Springer, 2005.

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21

Tsao, Peter Wing Hoi. Lymphocyte activation as a marker of experimental cardiac transplant rejection. 1992.

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22

De Bono, Christopher, Magali Théveniau-Ruissy, and Robert G. Kelly. Cardiac fields and myocardial cell lineages. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0004.

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We focus on the origin of myocardial cells in the first and second heart fields in splanchnic mesoderm in the early embryo. Genetic lineage tracing using Cre recombinase activated conditional reporter genes has made a major contribution to our understanding of cardiac progenitor cells and will be discussed together with other experimental approaches to analysing cell lineages at the clonal level. Interactions between myocardial, epicardial and endocardial lineages are essential for coordinated function and homeostasis of the normal heart. Perturbation of heart field development and myocardial
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23

(Editor), S. Sideman, and Rafael Beyer (Editor), eds. Interactive Phenomena in the Cardiac System (Advances in Experimental Medicine and Biology). Springer, 1994.

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24

(Editor), George B. Frank, C. Paul Bianchi (Editor), and H.E. Ter Keurs (Editor), eds. Excitation-Contraction Coupling in Skeletal, Cardiac and Smooth Muscle (Advances in Experimental Medicine and Biology). Springer, 2007.

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25

Yoris, Adrián, Adolfo M. García, Paula Celeste Salamone, Lucas Sedeño, Indira García-Cordero, and Agustín Ibáñez. Cardiac interoception in neurological conditions and its relevance for dimensional approaches. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198811930.003.0010.

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Dimensional and transdiagnostic approaches have revealed multiple cognitive/emotional alterations shared by several neuropsychiatric conditions. While this has been shown for externally triggered neurocognitive processes, the disruption of interoception across neurological disorders remains poorly understood. This chapter aims to fill this gap while proposing cardiac interoception as a potential common biomarker across disorders. It focuses on key aspects of interoception, such as the mechanisms underlying different interoceptive dimensions; the relationship among interoception, emotion, and s
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26

Waldenberger, Ferdinand R. Novel Cardiac Assist Devices With Different Unloading Capacities: An Experimental Study (Acta Biomedica Lovaniensia , No 107). Coronet Books Inc, 1995.

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27

Bartels, Karsten, and G. Burkhard Mackensen. Neuroprotection for Valvular and Coronary Artery Bypass Grafting Surgery. Edited by David L. Reich, Stephan Mayer, and Suzan Uysal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190280253.003.0016.

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Major cardiac surgery represents a unique biologic stimulus leading to profound perturbations in inflammatory, hemostatic, and oxidative stress pathways, all of which are implicated in the pathogenesis of perioperative cerebral injury. Despite significant advances in surgical, anesthetic, and neuroprotective strategies, these adverse cerebral outcomes have profound personal, clinical, and financial implications. Preventing or treating these adverse outcomes remains difficult because the underlying mechanisms remain incompletely understood, and most neuroprotective strategies generated in exper
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28

Menasché, Philippe. Stem Cell Therapy Post-AMI. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199544769.003.0010.

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• Experimental studies suggest that bone marrow-derived stem cells can improve function of infarcted myocardium• This benefit seems to involve paracrine signalling and limitation of left ventricular remodelling rather than true regeneration of cardiomyocytes from donor cells• These experimental findings have been translated in the clinical setting into significant, although moderate, improvements in cardiac function and LV remodelling but the extent to which these benefits impact on event-free long term survival remains to be determined• Optimisation of this therapeutic strategy will require a
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29

Selim, Bernardo, and Kannan Ramar. Beyond positive airway pressure therapy: experimental and non-conventional treatments in sleep apnoea. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0259.

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With decreased adherence to positive airway pressure therapy to treat sleep apnoeas, non-conventional treatments based on new therapeutic targets are emerging. In central sleep apnoea syndrome associated with heart failure, phrenic nerve stimulation and non-conventional pharmacological treatments such as carbonic anhydrase inhibitors, gas therapies, and cardiac devices are novel alternative therapies. In obstructive sleep apnoea, a better understanding of predominant pathophysiological pathways is characterizing diverse clinical phenotypes. For patients with low arousal threshold, sedatives or
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30

Giacca, Mauro, and Borja Ibáñez. Advanced therapies to treat cardiovascular diseases: controversies and perspectives. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0028.

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There is a pressing need to develop novel therapies for myocardial infarction and heart failure, two conditions that affect over 20% of the world population. Despite important advances in achieving revascularization of the ischaemic myocardium and the usefulness of devices in assisting failing hearts, therapy for these conditions remains poor. The final extent of myocardial tissue loss after infarction is a major determinant of post-infarction mortality due to heart failure. In this chapter we review the current strategies aimed at counteracting injury due to acute myocardial ischaemia–reperfu
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31

Pérez-Pomares, José M., and Robert Kelly, eds. The ESC Textbook of Cardiovascular Development. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.001.0001.

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A rapid inspection of the table of contents shows that we have grouped relevant cardiovascular developmental topics in five different sections, which move progressively from basic research to clinical relevance, concluding with a glance at the near future of this fast-moving field. All of these sections deal with concepts that are critical to understanding from where and how cardiac chambers (atria and ventricles), valves (atrioventricular and arterial), great vessels (aortic and pulmonary trunks), cardiac conduction system (nodes, bundles, and Purkinje fibres), and coronary blood vessels form
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32

The Matter of the Heart: A History of the Heart in Eleven Operations. Penguin Random House UK, 2017.

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33

Harding, Sian E. The Exquisite Machine. The MIT Press, 2022. http://dx.doi.org/10.7551/mitpress/12836.001.0001.

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How science is opening up the mysteries of the heart, revealing the poetry in motion within the machine. Your heart is a miracle in motion, a marvel of construction unsurpassed by any human-made creation. It beats 100,000 times every day—if you were to live to 100, that would be more than 3 billion beats across your lifespan. Despite decades of effort in labs all over the world, we have not yet been able to replicate the heart's perfect engineering. But, as Sian Harding shows us in The Exquisite Machine, new scientific developments are opening up the mysteries of the heart. And this explosion
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34

Stocchetti, Nino, and Marco Carbonara. Pharmacologic Neuroprotection. Edited by David L. Reich, Stephan Mayer, and Suzan Uysal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190280253.003.0002.

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Acute cerebral injury sets into motion a cascade of deleterious biochemical events that cause further neuronal damage and amplify deleterious effects. This cascade develops over time and potentially may be attenuated or limited by pharmacologic manipulation. The neuroprotective properties of several molecules have been clearly demonstrated in experimental models of various pathologies. Based on these findings, many promising compounds have been tested in clinical trials. Large randomized controlled trials, however, have repeatedly failed to provide evidence of clinical efficacy. The authors pr
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35

Downey, James, and Michael Cohen. Endogenous Mechanisms of Cardioprotection. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199544769.003.0008.

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• Ischaemic preconditioning is the most powerful endogenous mechanism for limiting myocardial infarct size in the experimental setting. Its clinical application is limited to scenarios in which the index episode of ischaemia and reperfusion can be anticipated such as in the setting of cardiac surgery• Ischaemic postconditioning represents an endogenous cardioprotective strategy which is applied at the onset of myocardial reperfusion, thereby allowing its use as an adjunct to reperfusion in patients presenting with an acute myocardial infarction• Both ischaemic preconditioning and postcondition
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36

Schaub, Mirjam. The Affective Experience of Space. Edited by Yael Kaduri. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199841547.013.21.

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This article investigates the aesthetic conclusions that the Canadian artists Janet Cardiff and George Bures Miller draw from the basic phenomenon of listening—such as the “horizon of simultaneity” of sound and vision—in their own creation of their audio- and video-walks. It describes how their work functions as social experiments in the public sphere. The thesis is that their works “vampirize” sounds and actively assimilate them to natural acoustic tracks and traces, thus becoming affective traps for their pursuers. Cardiff and Miller lead the participants astray in their desire to actually “
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37

Experimental Determination of Paraxial Ray Transfer Matrices and Cardinal Points of Complex Optical Systems by Means of Finite Conjugate Imaging. Storming Media, 2001.

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38

Babo-Rebelo, Mariana, and Catherine Tallon-Baudry. Interoceptive signals, brain dynamics, and subjectivity. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198811930.003.0003.

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The self has long been hypothesized to be rooted in the neural monitoring of bodily signals. We propose here to focus on visceral inputs, which present some key characteristics. Inputs from the heart or the gastrointestinal tract are continuously produced, and can reach multiple cortical targets. In addition, cardiac inputs elicit a neural response at each heartbeat that can be recorded non-invasively in humans, even in the absence of measurable changes in bodily state. We review the recent experimental evidence that neural responses to heartbeats are related to the self, in situations where t
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39

Wagner, Peter D. Gas exchange assessment in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0076.

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Chapter 75 laid out the basic principles that govern pulmonary gas exchange, a step necessary for the appropriate application and interpretation of common clinical tests of gas exchange. The present chapter discusses the several common tests and indices used to analyse and quantify gas exchange abnormalities in critically-ill patients. There is special emphasis on inherent limitations of each technique, as well as on ways to minimize technical and experimental errors when the necessary measurements are made. Limitations and errors are considered to be of major clinical importance because, whil
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40

Price, Susanna, and Pascal Vranckx. Portable (short-term) mechanical circulatory support. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0030.

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Mechanical circulatory support can be used to resuscitate patients, as a stabilizing measure for angiography and prompt revascularization, or to buy time until more definite measures can be taken. In addition, there is experimental evidence that ventricular unloading of the left ventricle can significantly reduce the infarct size. Different systems for mechanical circulatory support are available to the medical community. Treatment options for mechanical circulatory support must be tailored to each patient in order to maximize the potential benefits and minimize the risk of detrimental effects
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41

Price, Susanna, and Pascal Vranckx. Portable (short-term) mechanical circulatory support. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199687039.003.0030_update_001.

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Mechanical circulatory support can be used to resuscitate patients, as a stabilizing measure for angiography and prompt revascularization, or to buy time until more definite measures can be taken. In addition, there is experimental evidence that ventricular unloading of the left ventricle can significantly reduce the infarct size. Different systems for mechanical circulatory support are available to the medical community. Treatment options for mechanical circulatory support must be tailored to each patient in order to maximize the potential benefits and minimize the risk of detrimental effects
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42

Price, Susanna, and Pascal Vranckx. Portable (short-term) mechanical circulatory support. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199687039.003.0030_update_002.

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Mechanical circulatory support can be used to resuscitate patients, as a stabilizing measure for angiography and prompt revascularization, or to buy time until more definite measures can be taken. In addition, there is experimental evidence that ventricular unloading of the left ventricle can significantly reduce the infarct size. Different systems for mechanical circulatory support are available to the medical community. Treatment options for mechanical circulatory support must be tailored to each patient in order to maximize the potential benefits and minimize the risk of detrimental effects
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43

Bellomo, Rinaldo, and John R. Prowle. Pathophysiology of oliguria and acute kidney injury. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0211.

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Oliguria and acute kidney injury (AKI) are common in critically-ill patients with studies reporting AKI affecting more than 50% of critically-ill patients. AKI is independently associated with increased mortality and is a potentially modifiable aspect of critical illness. The pathogenesis of AKI is complex and varies according to aetiology. The most common trigger in ICU patients is sepsis—the pathophysiology of septic AKI is poorly understood and probably involves intrarenal haemodynamic and inflammatory processes. In the setting of septic AKI, the classic acute tubular necrosis described in
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44

Brazier, John, Julie Ratcliffe, Joshua A. Salomon, and Aki Tsuchiya. Modelling health state valuation data. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198725923.003.0005.

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This chapter examines the technical issues in modelling health state valuation data. Most measures of health define too many states to directly value all of them (e.g. SF-6D defines 18,000 health states). The solution has been to value a subset and by using modelling to predict the values of all states. This chapter reviews two approaches to modelling: one using multiattribute utility theory to determine health values given an assumed functional form; and the other is using statistical modelling of SF-6D preference data that are skewed, bimodal, and clustered by respondents. This chapter exami
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45

Turim, Maureen, and Michael Walsh. Sound Events. Edited by John Richardson, Claudia Gorbman, and Carol Vernallis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199733866.013.0026.

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This article appears in theOxford Handbook of New Audiovisual Aestheticsedited by John Richardson, Claudia Gorbman, and Carol Vernallis. This chapter is a comprehensive survey of sound practices in avant-garde film, video art, and installation art since the 1960s. It addresses a series of artistic approaches to sound: silence, tone and drone, antic and aleatory, multilayering and cacophony, work with voices, legacies of cinematic exhibition, and resonant spaces in galleries and museums. It is broadly chronological, beginning with major figures of the 1960s and ending with artists currently wor
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46

Frew, Anthony. Air pollution. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0341.

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Any public debate about air pollution starts with the premise that air pollution cannot be good for you, so we should have less of it. However, it is much more difficult to determine how much is dangerous, and even more difficult to decide how much we are willing to pay for improvements in measured air pollution. Recent UK estimates suggest that fine particulate pollution causes about 6500 deaths per year, although it is not clear how many years of life are lost as a result. Some deaths may just be brought forward by a few days or weeks, while others may be truly premature. Globally, household
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47

Guimarães, Thiago Teixeira, Daniel Costa Alves da Silva, Elaine Cristina da Silva Pinto, et al. Excesso de exercício físico? Brazilian Journals Editora, 2022. http://dx.doi.org/10.35587/brj.ed.0001379.

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Nos últimos anos, alguns questionamentos nortearam a minha busca pelo conhecimento nas ciências do exercício e esporte. O exercício físico sempre é benéfico? O excesso de exercícios físicos entre atletas é uma realidade? Do que se trata o overtraining? Qual a diferença entre overtraining e overreaching? Deve-se evitar exercícios extremos? Há uma linha tênue entre benefícios e prejuízos modulados pelo exercício físico? O excesso de exercícios físicos entre atletas de recreação é uma realidade? O exercício físico pode apresentar “efeitos colaterais”? Qual a origem do overtraining? Quanto mais ex
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48

Howard, Colin R. Arenaviruses. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0032.

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There are few groups of viral zoonoses that have attracted such widespread publicity as the arenaviruses, particularly during the 1960’s and 1970’s when Lassa emerged as a major cause of haemorrhagic disease in West Africa. More than any other zoonoses, members of the family are used extensively for the study of virus-host relationships. Thus the study of this unique group of enveloped, single-stranded RNA viruses has been pursued for two quite separate reasons. First, lymphocytic choriomeningitis virus (LCM) has been used as a model of persistent virus infections for over half a century; its
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