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Dissertations / Theses on the topic 'Cardiac experiments'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Carrick, Richard T. "A Mechanistically Guided Approach to Treatment of Multi-Wavelet Reentry: Experiments in a Computational Model of Cardiac Propagation." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/539.

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Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States today. However, treatment options remain limited despite the enormous magnitude of both AF prevalence and the associated economic cost. Of those treatment options that are available, ablation-based interventional methods have demonstrated the highest rates of long-term cure. Unfortunately, these methods have substantially lower efficacy in patients with heavier burdens of disease, thus leaving the most affected individuals with the least hope for successful treatment. The focus of this research is to develop a

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2

Devenyi, Ryan Allyn. "Quantifying the Affairs of the Heart| Combining Population-based Modeling and Experiments to Understand the Roots of Key Behaviors in Cardiac Myocytes." Thesis, Icahn School of Medicine at Mount Sinai, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10809290.

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<p> Electrophysiological behaviors in cardiomyocytes, such as the action potential and calcium transient, are emergent properties arising from the interaction of an ensemble of ion channels, transporters, and pumps. In this Thesis, I integrate mathematical modeling with experiments to gain new insight into cardiac electrophysiology. Cardiomyocyte models are probed using population-based parameter sensitivity analysis to comprehensively generate quantitative predictions of how key behaviors are determined by the levels of ion channels, transporters, and pumps. Experimental tests ground these pr

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3

de, Julien de Zelicourt Diane Alicia. "A Mechanical Fluid Assessment of Anatomical Models of the Total Cavopulmonary Connection (TCPC)." Thesis, Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/4882.

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BACKGROUND: Understanding the hemodynamics of the total cavopulmonary connection (TCPC) may lead to further optimization of the connection design and surgical planning, which in turn may lead to improved surgical outcome. While most experimental and numerical investigations have mainly focused on somewhat simplified geometries, the investigation of the flow field of true TCPC configurations is necessary for a true understanding. METHODS: This study details a manufacturing methodology yielding more accurate in vitro models that would provide a better understanding of the TCPC hemodynamics and

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4

Du, Dongping. "Physical-Statistical Modeling and Optimization of Cardiovascular Systems." Scholar Commons, 2002. http://scholarcommons.usf.edu/etd/5875.

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Heart disease remains the No.1 leading cause of death in U.S. and in the world. To improve cardiac care services, there is an urgent need of developing early diagnosis of heart diseases and optimal intervention strategies. As such, it calls upon a better understanding of the pathology of heart diseases. Computer simulation and modeling have been widely applied to overcome many practical and ethical limitations in in-vivo, ex-vivo, and whole-animal experiments. Computer experiments provide physiologists and cardiologists an indispensable tool to characterize, model and analyze cardiac function

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5

Bezuidenhout, Nicole Joy. "A study of the early changes in hearts from diet-induced obese rats that may lead to cardiac dysfunction." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6757.

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Thesis (MScMedSc)--University of Stellenbosch, 2011.<br>ENGLISH ABSTRACT: INTRODUCTION: Obesity and its associated complications such as diabetes and cardiovascular disease are escalating worldwide. Cardiovascular mortality and the occurrence of heart failure following a myocardial infarction are increased among diabetics. A high caloric diet has been associated with specific metabolic alterations such as increased FA utilization and decreased glucose utilization. We therefore hypothesized that, in a rat model of diet-induced obesity, pathways involved in myocardial glucose utilization would b

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6

Чайковська, О. В., Н. С. Барзак, О. В. Власенко та М. В. Йолтухівський. "Багатоканальний електрофізіологічний комплекс для оцінки дії фармакологічних препаратів на міокард". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/55122.

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Актуальність: Серцево-судинні захворювання на сьогоднішній день є основною причиною смертності, а розробка нових препаратів – пріоритетним напрямком досліджень. Традиційно провідність в міокарді оцінюють за тривалістю інтервалу PQ на електрокардіограмі. Вдосконалення можливостей технічних засобів реєстрації електричної активності та роботи серця дає можливість детальніше дослідити та проаналізувати параметри міжклітинної взаємодії кардіоміоцитів та проведення імпульсу по провідній системі. Використання нових методів експериментальної фізіології дасть можливість деталізувати наявні моделі карді

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7

Beraldo, Oswaldo Antonio. "Processamento digital do sinal de eletrocardiograma para aplicação em experimentos de fisiologia cardíaca." Universidade de São Paulo, 1997. http://www.teses.usp.br/teses/disponiveis/18/18133/tde-27112017-142134/.

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Neste trabalho é descrito um sistema para aquisição e processamento do sinal de eletrocardiograma (ECG) para uso em experimentos de fisiologia cardíaca adaptativa de animais aquáticos (peixes). A aplicação imediata destina-se ao Laboratório de Zoofisiologia e Bioquímica Comparativa do Departamento de Ciências Fisiológicas da Universidade Federal de São Carlos. Um algoritmo de processamento do sinal de ECG é proposto, implementado e comparado com outros dois algoritmos, descritos na literatura especializada, tendo demonstrado ótimo desempenho. Um sistema de controle de experimentação, onde as c

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8

Nikam, Shantanu P. "LOCALIZED ANTIBIOTIC DELIVERY VIA VALINE BASED POLY(ESTER UREA)." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1522931095020122.

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9

Kelloniemi, A. (Annina). "Novel factors regulating cardiac remodeling in experimental models of cardiac hypertrophy and failure." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526220291.

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Abstract Cardiac loading induces left ventricular hypertrophy and cardiac remodeling which when prolonged, leads to heart failure, a complex syndrome affecting approximately 1-2% of the adult population of the Western world with a prevalence increasing with age. Pathological remodeling involves functional and structural changes that are associated with fetal gene expression, sarcomeric re-organization, hypertrophy of cardiomyocytes, fibrosis, inflammation, oxidative stress and impairment of metabolism. The aim of this study was to investigate the role of three novel factors during the cardiac

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10

Brosnan, Mary Julia. "Experimental models of cardiomyopathy in the rat." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253329.

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11

Löwbeer, Christian. "Cardiac troponin T in clinical and experimental studies /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-426-6/.

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12

Lygate, Craig Alexander. "Comparative studies in experimental hypertension and cardiac failure." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312137.

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13

Chen, Jiamin. "Sepsis-induced cardiac dysfunction : pathophysiology and experimental treatments." Thesis, Queen Mary, University of London, 2016. http://qmro.qmul.ac.uk/xmlui/handle/123456789/23200.

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The severity of cardiac dysfunction predicts mortality in septic patients. In this thesis, I have investigated the pathophysiology and the novel therapeutic strategy to attenuate cardiac dysfunction in experimental sepsis. I have developed a model of cardiac dysfunction caused by lipopolysaccharide (LPS)/peptidoglycan (PepG) co-administration or polymicrobial sepsis in young and old, male and female mice. There is good evidence that females tolerate sepsis better than males. Here, I have demonstrated for the first time that the cardiac dysfunction caused by sepsis was less pronounced in female

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14

Smith, Joseph Martin. "The stochastic nature of cardiac electrical instability : theory and experiment." Thesis, Massachusetts Institute of Technology, 1985. http://hdl.handle.net/1721.1/14339.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Harvard-MIT Division of Health Sciences and Technology, 1986.<br>Vita.<br>Includes bibliographical references (leaves 190-206).<br>by Joseph Martin Smith.<br>Ph.D.

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15

Rysä, J. (Jaana). "Gene expression profiling in experimental models of cardiac load." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514287664.

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Abstract Cardiac hypertrophy provides an adaptive mechanism to maintain cardiac output in response to increased workload, and although initially beneficial, hypertrophy eventually leads to heart failure, a major cause of morbidity and mortality in Western countries. The hypertrophic response in cardiac myocytes is accompanied by e.g. activation of signal transduction pathways, such as mitogen-activated protein kinases (MAPKs), and complex changes in gene programming. The purpose of this study was to characterize gene expression patterns in experimental models of cardiac load by using high-thro

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16

Al, Zoubi Sura Yahia Yosef. "Diabetes and the cardiac dysfunction caused by experimental sepsis." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/43943.

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Sepsis is the leading cause of death in ICU patients. Patients with sepsis may develop sepsis-related cardiac dysfunction. The presence of this cardiac dysfunction can increase the mortality rate from 40% to 70%. Diabetes is a chronic disease that manifests as an elevation in blood glucose. Patients with diabetes are more susceptible to, and at increasing risk of developing, infections and subsequently sepsis. Activation of the NF-ĸB pathway plays a crucial role in the pathophysiology of sepsis-associated cardiac dysfunction and diabetic cardiomyopathy. The effect of diabetes on outcomes in pa

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17

Bazan, Ovandir. "Estudo experimental de escoamento pulsátil através de biopróteses valvulares cardíacas mitrais a partir do desenvolvimento de um simulador do lado esquerdo do coração." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/3/3150/tde-26122014-115259/.

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Uma vez que a maioria das complicações relacionadas ao funcionamento das próteses de válvulas cárdicas é devida aos distúrbios de escoamento, a sua caracterização hidrodinâmica é um auxílio útil no projeto de novas válvulas. Simulações do escoamento pulsátil através de próteses de válvulas cardíacas começaram há cerca de 60 anos, por meio do desenvolvimento de diferentes simuladores cardíacos, melhorando a interpretação dos resultados clínicos. Para o presente estudo, um simulador cardíaco foi desenvolvido completamente na Escola Politécnica da Universidade de São Paulo, no Departamento de Eng

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18

Patel, Vinood Bhagwandas. "Biochemical investigations into experimental alcoholic cardiomyopathy and hypertension." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266477.

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19

Costa, Eunice Cristina da Silva. "Glicogenio cardiaco em diabetes experimental : efeitos do tratamento com metformina e/ou glibenclamida sobre as funções cardiacas em coração isolado." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313912.

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Orientador: Antonio Ari Gonçalves<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-04T15:30:30Z (GMT). No. of bitstreams: 1 Costa_EuniceCristinadaSilva_D.pdf: 2678840 bytes, checksum: 439eb1d320bc5d4828c77cb0e086e763 (MD5) Previous issue date: 2005<br>Resumo: Objetivos: Metformina e glibenclamida são fármacos utilizados para diminuir a glicemia de diabéticos tipo 2. Metformina reduz a absorção gastrintestinal de glicose e a gliconeogênese hepática e aumenta a captação de glicose periférica. Por sua vez, glibenclamida aument

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20

Li, Xing. "Histamine H¦3 activation depresses cardiac function in experimental sepsis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ41733.pdf.

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21

Krimpen, Cornelis van. "Cardiac remodeling and angiotensin II after an experimental myocardial infarction." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1991. http://arno.unimaas.nl/show.cgi?fid=5677.

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22

Dimitrova, Maria. "The effect of experimental diabetes on the cardiac oxytocin system." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86865.

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Objective: To elucidate the effect of type I diabetes mellitus on the cardio-protective oxytocin (OT)-natriuretic peptides (NPs)-nitric oxide (NO) signaling cascade.<br>Methods: 200-250 grams Male Wistar rats injected intraperitoneally with 65 mg/kg streptozotocin (STZ) to induce experimental diabetes were sacrificed 5.5 and 10.5 weeks later. Gene and protein expression levels were determined by Real-Time PCR and Western blot, respectively.<br>Results: A significant increase in the gene expression of OT in the left ventricle (LV) was found after both 5.5 (640%) and 10.5-weeks (420%) of diabete

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23

Araujo, Izilda Esmenia Muglia 1955. "Efeitos da angiotensina-II na parada cardiaca induzida por fibrilação ventricular : estudo experimental." [s.n.], 1992. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311715.

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Orientador : Renato G.G. Terzi<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-07-17T10:31:11Z (GMT). No. of bitstreams: 1 Araujo_IzildaEsmeniaMuglia_M.pdf: 1211797 bytes, checksum: 7d4284e99293b1b46cfa9b7086815797 (MD5) Previous issue date: 1992<br>Resumo: O aumento do tônus vascular periférico com drogas alfa-adrenérgicas é vital para a restauração da circulação espontânea (RCE*) durante a ressuscitação cardiopulmonar (RCP). Nós estudamos os efeitos da Angiotensina 11 (A-II), um potente vasoconstrictor não-adr

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24

Gay, Jordi Gemma. "Efecte de l’exercici crònic en el desenvolupament de fibrosi cardíaca: mecanismes implicats." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/36460.

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Recentment s’ha descrit que la pràctica intensa d’exercici pot provocar anomalies en la morfologia, funcionalitat i bioquímica del cor, incrementant el risc de patir arítmies. Tot i aquesta associació entre la pràctica intensa d’exercici físic i l’aparició d’arítmies auriculars i ventriculars, no existeix un consens absolut respecte si aquests fenòmens es deuen a malalties cardíaques no diagnosticades (on l’exercici podria ser un factor desencadenant) o en realitat l’exercici és la causa primària que els origina. Per avaluar la hipòtesi de que l’exercici intens provoca el desenvolupament de fi

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25

Crick, Simon John. "Innervation of the conduction system and other cardiac tissues in men and animal models." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286229.

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26

Axelsson, Birger. "Cardiac effects of non-adrenergic inotropic drugs : clinical and experimental studies." Doctoral thesis, Umeå universitet, Anestesiologi och intensivvård, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68967.

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Background: Myocardial failure and dysfunction is not uncommon during critical illness and following cardiac surgery. For optimal treatment, a better understanding of the effects of inotropic drugs is needed. In this thesis, two non-adrenergic mediated inotropes, milrinone and levosimendan were studied in different models of myocardial dysfunction. The study aims were to assess the following: the effects of milrinone on blood flow in coronary artery bypass grafts during CABG surgery; the effects of milrinone on left ventricular diastolic function during post-ischaemic myocardial dysfunction; w

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27

ShariÌ„f, Ê¿IsÌ£aÌ„m. "Role of endothelin in experimental models of ischaemia induced cardiac arrhythmias." Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249886.

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28

Nascimento, André Ferreira do [UNESP]. "Relação entre diferentes períodos da exposição à obesidade induzida por dieta e lipotoxidade cardíaca: papel do eixo Leptina/OB0R/AMPK/ACC/Malonil CoA." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/102639.

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Made available in DSpace on 2014-06-11T19:32:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-06-15Bitstream added on 2014-06-13T20:03:20Z : No. of bitstreams: 1 nascimento_af_dr_botfm.pdf: 1541050 bytes, checksum: 9fae4f69a9aa734a76ae03632e1bca64 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Acúmulo de lipídeo no citoplasma do miócito é associado com disfunção e morte celular, um processo conhecido como lipotoxicidade cardíaca. Leptina, um hormônio produzido no tecido adiposo, atua como reguladora do metabolismo lipídico e desempenha um papel anti-

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Vilarinho, Karlos Alexandre de Sousa 1976. "Desenvolvimento de modelo experimental de insuficiencia cardiaca em coelhos." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311520.

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Orientador: Orlando Petrucci Junior<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T17:47:29Z (GMT). No. of bitstreams: 1 Vilarinho_KarlosAlexandredeSousa_M.pdf: 5350475 bytes, checksum: 25a2a28e1fa1a21cc4b04d4aa5532e11 (MD5) Previous issue date: 2008<br>Resumo: Introdução: É importante o desenvolvimento de modelos reprodutíveis de insuficiência cardíaca, para melhor entendimento da fisiopatopatologia, desenvolvimento e validação de métodos terapêuticos nessa síndrome. Poucos experimentos comparam os model

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30

Hao, Guoliang. "Imaging of the atria and cardiac conduction system : from experiment to computer modelling." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/imaging-of-the-atria-and-cardiac-conduction-system--from-experiment-to-computer-modelling(3e5dba52-70f3-4fa8-890d-adfe2380086c).html.

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Background: Experimental mapping and computer modelling provide important platforms to study the fundamental mechanisms underlying normal and abnormal activation of the heart. However, accurate computer modelling requires detailed anatomical models and needs support and validation from experimental data. Aims: 1) Construction of detailed anatomical heart models with the cardiac conduction system (CCS). 2) Mapping of the electrical activation sequence in rabbit atria to support and validate computer simulation. 3) Mapping of the spontaneous activity in the atrioventricular ring tissues (AV ring

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Nelina, E. V. "Experimental and morphological research of the afferent terminations of different cardiac nerves." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/55333.

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Introduction. Over 80 years the anatomy by request of applied medicine studies a structure of the sensitive terminations of different nerves in heart of mammals. The most in details studied terminations of the wandering nerves. Work purpose. To investigate the afferent terminations of different cardiac nerves.

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32

Mariotti, Erika. "Experimental protocols and analysis methods for real-time assessment of cardiac metabolism." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/experimental-protocols-and-analysis-methods-for-realtime-assessment-of-cardiac-metabolism(1d8de5c5-3d55-43fa-b3f6-38595fce1188).html.

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Cardiovascular disease remains the primary cause of death worldwide. Medical imaging plays a critical and increasing role in both its diagnosis and characterisation. Recent advances in hyperpolarised 13C Magnetic Resonance (MR) allow, for example, imaging an injected molecule and its downstream metabolites to uncover biochemical changes in the myocardium. On the other hand, radionuclide imaging using Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) has significantly higher sensitivity than MR, but the signals from injected tracers and their metabolites

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Britton, Oliver Jonathan. "Combined experimental and computational investigation into inter-subject variability in cardiac electrophysiology." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:6299240d-0528-4662-8e1f-5025f39e730f.

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The underlying causes of variability in the electrical activity of hearts from individuals of the same species are not well understood. Understanding this variability is important to enable prediction of the response of individual hearts to diseases and therapies. Current experimental and computational methods for investigating the behaviour of the heart do not incorporate biological variation between individuals. In experimental studies, experimental results are averaged together to control errors and determine the average behaviour of the studied organism. In computational studies, averaged

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Antonucci, Salvatore. "Relationships between mitochondrial [Ca2+] and ROS in experimental model of cardiac disease." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426675.

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Changes in intracellular [Ca2+] ([Ca2+]I) homeostasis, mitochondrial dysfunction and reactive oxygen species (ROS) are generally intertwined. Therefore, it is difficult to establish sequence of events and causal relationships. For instance, an increase in [Ca2+]I affects mitochondrial [Ca2+] and in most cases it is associated with an increased mitochondrial ROS formation, leading to the opening of the permeability transition pore (PTP), mitochondrial dysfunction and cell death. On the other hand, ROS modify [Ca2+]I homeostasis by acting at various sites involved in intracellular Ca2+ fluxes. T

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Nascimento, André Ferreira do. "Relação entre diferentes períodos da exposição à obesidade induzida por dieta e lipotoxidade cardíaca : papel do eixo Leptina/OB0R/AMPK/ACC/Malonil CoA /." Botucatu : [s.n.], 2010. http://hdl.handle.net/11449/102639.

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Orientador: Antonio Carlos Cicogna<br>Banca: Ana Lúcia dos Anjos Ferreira<br>Banca: Marina Politi Okoshi<br>Banca: Alessandra Medeiros<br>Banca: Edilamar Menezes de Oliveira<br>Resumo: Acúmulo de lipídeo no citoplasma do miócito é associado com disfunção e morte celular, um processo conhecido como lipotoxicidade cardíaca. Leptina, um hormônio produzido no tecido adiposo, atua como reguladora do metabolismo lipídico e desempenha um papel anti-esteatose; em contraste, resistência à leptina tem sido associada com lipotoxicidade. É incerto se resistência à leptina pode ser um fator de risco para l

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36

Soleimani, Behzad. "Mechanisms of Cardiac Allograft Vasculopathy : Insights from experimental models of transplant intimal hyperplasia." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498247.

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37

Masson, Gustavo Santos. "Efeito de diferentes metodologias de treinamento físico na função cardíaca e no controle barorreflexo cardíaco em modelo experimental de cardiopatia dilatada isquêmica." reponame:Repositório Institucional da FIOCRUZ, 2010. https://www.arca.fiocruz.br/handle/icict/6060.

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Submitted by Tatiana Silva (tsilva@icict.fiocruz.br) on 2012-12-26T17:37:12Z No. of bitstreams: 1 gustavo_s_masson_ioc_bcm_0017_2010.pdf: 411061 bytes, checksum: c24ac1e7c8586dc59e7e02ab251a8183 (MD5)<br>Made available in DSpace on 2012-12-26T17:37:12Z (GMT). No. of bitstreams: 1 gustavo_s_masson_ioc_bcm_0017_2010.pdf: 411061 bytes, checksum: c24ac1e7c8586dc59e7e02ab251a8183 (MD5) Previous issue date: 2010<br>Fundação Oswaldo Cruz.Instituto Oswaldo Cruz. Rio de janeiro, RJ, Brasil<br>Introdução: O treinamento físico contínuo (Cont) é tradicionalmente empregado como estratégia terapêutica n

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Lal, Mark. "Oxidative stress and calcium signalling : implications for diabetes and cardiac glycosides /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-583-2/.

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Xavier, Marcelo Souza. "Efeito do azul de metileno como adjuvante no desfecho da parada cardíaca: estudo experimental em ratos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-02072018-123155/.

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INTRODUÇAO: O uso da epinefrina na ressuscitação cardiopulmonar (RCP) tem sido questionado devido aos efeitos adversos como dano miocárdico e cerebral. Fármacos como azul de metileno têm sido estudados como adjuvantes, objetivando reduzir essas lesões. OBJETIVOS: Neste estudo objetivou-se avaliar o efeito da administração do azul de metileno em bôlus durante a RCP, na lesão miocárdica e cerebral. MÉTODO: Quarenta e nove ratos Wistar machos submetidos a parada cardíaca por fibrilação ventricular foram distribuídos aleatoriamente em quatro grupos com 11 animais: azul de metileno (GA, 2mg/kg), so

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Mantovani, Vittorio. "Myocardial metabolism and ischemia assessed by microdialysis : clinical and experimental studies in cardiac surgery /." Göteborg : Institution of Medicine, Dept. of Metabolic and Cardiovascular Research / Cardiovascular Surgery, Sahlgrenska Academy at Göteborg University, 2006. http://hdl.handle.net/2077/754.

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Asfour, Boulos. "Experimental design for cardiac gene therapy : rat heart transplantation models and gene transfer techniques /." Münster : Schüling, 2000. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=008939687&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Roscani, Meliza Goi [UNESP]. "Evolução das modificações morfo-funcionais cardíacas no processo de adaptação crônica à insuficiência aórtica aguda experimental em ratos." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/102643.

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Made available in DSpace on 2014-06-11T19:32:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-10Bitstream added on 2014-06-13T21:03:38Z : No. of bitstreams: 1 roscani_mg_dr_botfm.pdf: 1793815 bytes, checksum: ef58e271a6e22be8d19da25e6d3d13c8 (MD5)<br>A adaptação cardíaca à insuficiência aórtica resulta em hipertrofia excêntrica seguida de disfunção ventricular e insuficiência cardíaca. A evolução desse processo ainda não é bem compreendida. Avaliar a adaptação cardíaca à insuficiência aórtica aguda experimental por meio de ecocardiografia, identificar os marcadores anatâmicos de

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Carieli, Maria do Carmo Monteiro. "Eficacia da vasopressina isolada e combinada com a adrenalina e noradrenalina na ressuscitação cardorrespiratoria : estudo experimental na fibrilação ventricular." [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/321178.

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Orientador: Sebastião Araujo<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-03T15:46:42Z (GMT). No. of bitstreams: 1 Carieli_MariadoCarmoMonteiro_M.pdf: 20553600 bytes, checksum: cbe1c1836b2ef84af729ede82e252745 (MD5) Previous issue date: 2002<br>Mestrado

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Fonseca, Eliana Bonetti. "Comparação da variação da pressão sistólica e de pulso nas ventilações com pressão e volume controlados: estudo experimental em coelhos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-28012007-103110/.

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Introdução: A Variação da Pressão Sistólica (VPS) e da Pressão de Pulso (VPP) têm sido propostas como métodos efetivos para monitoração hemodinâmica, em predizer a resposta à reposição da volemia durante a ventilação mecânica. A primeira é calculada pela diferença entre a pressão sistólica máxima e mínima em um ciclo respiratório, e composta pela somatória dos componentes delta up e delta down; e a VPP obtida pela diferença entre a pressão sistólica e diastólica também em um ciclo respiratório. O objetivo deste estudo foi avaliar a VPS e seus componentes, e a VPP durante a ventilação com volum

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Molnar, Maria. "Hyperglycemia in Experimental Cerebral Ischemia." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-247763.

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Cerebral ischemia is a life-threatening condition associated with a substantial morbidity and mortality. Hyperglycemia, a common coexisting phenomenon in both stroke and cardiac arrest (CA), may further aggravate ischemic brain injury. To date, the therapeutic possibilities are lim-ited and the search for new treatment modalities is warranted. One aspect of such a research could be to better understand the cerebral pathogenesis induced by hyperglycemic ischemia-reperfusion. We investigated the combination of ischemia and hyperglycemia in two experimental models of stroke and CA. The aims were

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Scoote, Mark. "Functional characterisation of the intracellular calcium release channel in experimental models of cardiac patho-physiology." Thesis, Imperial College London, 2005. http://hdl.handle.net/10044/1/11249.

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Shiraiwa, Keigo. "Changes in electroencephalography and cardiac autonomic function during craft activities : experimental evidence for the effectiveness of occupational therapy." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263589.

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Thomal, Raquel Agibert. "Avaliação da função cardíaca em modelo experimental de hipotireoidismo." reponame:Repositório Institucional da UFPR, 2010. http://hdl.handle.net/1884/21552.

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Marques, Gustavo Lenci. "Estresse oxidativo no envelhecimento cardíaco : estudo experimental em ratos." reponame:Repositório Institucional da UFPR, 2015. http://hdl.handle.net/1884/38195.

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Orientador: Prof. Dr. Ronaldo da R.L. Bueno<br>Co-orientador : Prof. Dr. Rogério de Fraga<br>Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Medicina Interna. Defesa : Curitiba, 13/02/2015<br>Inclui referências<br>Resumo: Introdução: Diversas teorias já foram propostas para tentar explicar o envelhecimento, mas ainda não temos pleno conhecimento sobre os fatores que afetam esse complexo processo. Entre as teorias elaboradas uma das mais estudadas é a de que o envelhecimento se dá pelo acúmulo de dano oxidativo com o tempo. E um

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Leopoldo, André Soares [UNESP]. "Influência do tempo de exposição à obesidade sobre a função cardíaca de ratos." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/100938.

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Made available in DSpace on 2014-06-11T19:31:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-22Bitstream added on 2014-06-13T20:41:16Z : No. of bitstreams: 1 leopoldo_as_dr_botfm_prot.pdf: 3513369 bytes, checksum: 922f5bbd3b24a15e940c8cfa86cf1680 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>not available

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