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Journal articles on the topic 'Cardiac experiments'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Mohiuddin, Muhammad, Gary Kline, Zhenya Shen, Vincent Ruggiero, Susan Rostami, and Verdi J. DiSesa. "Experiments in cardiac xenotransplantation." Journal of Thoracic and Cardiovascular Surgery 106, no. 4 (1993): 632–35. http://dx.doi.org/10.1016/s0022-5223(19)33704-3.

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2

Li, Wen-jing, Han Yan, Zi-ying Zhou, et al. "Cryptotanshinone Attenuated Pathological Cardiac Remodeling In Vivo and In Vitro Experiments." Oxidative Medicine and Cellular Longevity 2023 (January 27, 2023): 1–17. http://dx.doi.org/10.1155/2023/4015199.

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Objective. Cardiac remodeling has been demonstrated to be the early stage and common pathway for various types of cardiomyopathy, but no specific treatment has been suggested to prevent its development and progress. This study was aimed at assessing whether Cryptotanshinone (CTS) treatment could effectively attenuate cardiac remodeling in vivo and in vitro. Methods. Aortic banding (AB) surgery was performed to establish a pressure-overload-induced mouse cardiac remodeling model. Echocardiography and pressure-volume proof were used to examine mouse cardiac function. Hematoxylin and eosin (HE) a

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3

Pruski, Jan C., Amir Abduljalil, and Pierre-Marie Robitaille. "Improved cardiac gating and ventilation timing in animal experiments." Magnetic Resonance in Medicine 27, no. 2 (1992): 329–37. http://dx.doi.org/10.1002/mrm.1910270212.

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4

Kamali Shahri, Seyed Mehdi, Christian Contarino, Francesco Chifari, Morteza Mahmoudi, and Simon Gelman. "Function of arteries and veins in conditions of simulated cardiac arrest." BioImpacts 11, no. 2 (2021): 157–64. http://dx.doi.org/10.34172/bi.2021.13.

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Introduction: The study examined the behavior of vasculature in conditions of eliminated cardiac function using mathematical modeling. In addition, we addressed the question of whether the stretch-recoil capability of veins, at least in part accounts for the slower response to simulated cardiac arrest. Methods: In the first set of computational experiments, blood flow and pressure patterns in veins and arteries during the first few seconds after cardiac arrest were assessed via a validated multi-scale mathematical model of the whole cardiovascular system, comprising cardiac dynamics, arterial

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5

JACOB, R., H. RUPP, M. BRANDLE, and K. NOMA. "Factors responsible for manifestation of cardiac failure in chronic experiments." Journal of Molecular and Cellular Cardiology 19 (1987): S37. http://dx.doi.org/10.1016/s0022-2828(87)80119-0.

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6

Ankersmit, Hendrik J. "From xenograft experiments to xenograft immune responses in cardiac surgery*." Xenotransplantation 19, no. 5 (2012): 271–72. http://dx.doi.org/10.1111/j.1399-3089.2012.00720.x.

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7

Chen, Olivia, and Li Qian. "Direct Cardiac Reprogramming: Advances in Cardiac Regeneration." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/580406.

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Heart disease is one of the lead causes of death worldwide. Many forms of heart disease, including myocardial infarction and pressure-loading cardiomyopathies, result in irreversible cardiomyocyte death. Activated fibroblasts respond to cardiac injury by forming scar tissue, but ultimately this response fails to restore cardiac function. Unfortunately, the human heart has little regenerative ability and long-term outcomes following acute coronary events often include chronic and end-stage heart failure. Building upon years of research aimed at restoring functional cardiomyocytes, recent advanc

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Watson, P. A., R. Hannan, L. L. Carl, and K. E. Giger. "Desmin gene expression in cardiac myocytes is responsive to contractile activity and stretch." American Journal of Physiology-Cell Physiology 270, no. 4 (1996): C1228—C1235. http://dx.doi.org/10.1152/ajpcell.1996.270.4.c1228.

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Experiments were performed to assess the ability of mechanical stimuli, experienced by ventricular cardiac myocytes during the progression of hypertrophic and dilated pathology, to increase the expression of desmin in cultured neonatal rat cardiac myocytes. Results indicate that both contractile activity and load due to passive stretch increase desmin content in neonatal rat cardiac myocytes through increased desmin gene transcription. Western blot analysis demonstrated that contraction induced a selective increase in desmin protein content in neonatal rat cardiac myocytes above increases obse

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9

Rismani Yazdi, Saeed, Amir Shadmani, Sebastian C. Bürgel, Patrick M. Misun, Andreas Hierlemann, and Olivier Frey. "Adding the ‘heart’ to hanging drop networks for microphysiological multi-tissue experiments." Lab on a Chip 15, no. 21 (2015): 4138–47. http://dx.doi.org/10.1039/c5lc01000d.

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10

Drovandi, C. C., N. Cusimano, S. Psaltis, et al. "Sampling methods for exploring between-subject variability in cardiac electrophysiology experiments." Journal of The Royal Society Interface 13, no. 121 (2016): 20160214. http://dx.doi.org/10.1098/rsif.2016.0214.

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Between-subject and within-subject variability is ubiquitous in biology and physiology, and understanding and dealing with this is one of the biggest challenges in medicine. At the same time, it is difficult to investigate this variability by experiments alone. A recent modelling and simulation approach, known as population of models (POM), allows this exploration to take place by building a mathematical model consisting of multiple parameter sets calibrated against experimental data. However, finding such sets within a high-dimensional parameter space of complex electrophysiological models is

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11

ZHANG, H., D. NOBLE, M. CANNELL, et al. "DYNAMICS OF CARDIAC INTRACELLULAR Ca2+ HANDLING — FROM EXPERIMENTS TO VIRTUAL CELLS." International Journal of Bifurcation and Chaos 13, no. 12 (2003): 3535–60. http://dx.doi.org/10.1142/s0218127403008843.

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Intracellular cardiac Ca 2+ handling involves interactions of numerous distinct cellular and macromolecular structures. Such interactions coordinate the complicated behaviors of individual processes into spatial and temporal coherent patterns of Ca 2+ sparks, oscillations and traveling waves. Understanding the dynamical behaviors and functional roles of intracellular Ca 2+ handling requires not only detailed experimental information about subcellular structures and dynamics, but also useful tools to integrate and analyze this information. This requires interactions between experimental and sim

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12

Babini, Giovanni, Luigi Grassi, Ilaria Russo, et al. "Duration of Untreated Cardiac Arrest and Clinical Relevance of Animal Experiments." SHOCK 49, no. 2 (2018): 205–12. http://dx.doi.org/10.1097/shk.0000000000000914.

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13

Konstantinov, B. A., S. L. Dzemeshkevich, S. M. Krasovskaya, et al. "New cardiac bioprostheses: Theory, experiments, and 10 years of clinical use." Annals of Thoracic Surgery 48, no. 3 (1989): S79—S80. http://dx.doi.org/10.1016/0003-4975(89)90649-8.

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14

MALIK, MAREK, and A. JOHN CAMM. "Cardiac Electrophysiological Experiments in Numero, Part II: Models of Electrophysiological Processes." Pacing and Clinical Electrophysiology 14, no. 11 (1991): 1648–71. http://dx.doi.org/10.1111/j.1540-8159.1991.tb02741.x.

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15

Brady, A. J., J. B. Warren, P. A. Poole-Wilson, T. J. Williams, and S. E. Harding. "Nitric oxide attenuates cardiac myocyte contraction." American Journal of Physiology-Heart and Circulatory Physiology 265, no. 1 (1993): H176—H182. http://dx.doi.org/10.1152/ajpheart.1993.265.1.h176.

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Cardiac muscle fibers have microvessels in close proximity, the distance from the nearest capillary being no greater than 8 microns. We performed experiments on isolated, electrically stimulated, contracting guinea pig cardiac myocytes to test whether NO from endothelium or nitrovasodilators or directly superfused in solution might affect myocyte contractility. In endothelium-myocyte coculture experiments, 10(-7) M bradykinin reduced myocyte shortening by 11 +/- 3.5%. This effect was abolished in the presence of NG-nitro-L-arginine methyl ester and was unaffected by indomethacin. Sodium nitrop

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16

Jacob, G., N. Nassar, G. Hayam, et al. "Cardiac function and responsiveness to beta-adrenoceptor agonists in rats with obstructive jaundice." American Journal of Physiology-Gastrointestinal and Liver Physiology 265, no. 2 (1993): G314—G320. http://dx.doi.org/10.1152/ajpgi.1993.265.2.g314.

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The function and role of the heart and the contribution of cardiac beta-adrenoceptors in the pathogenesis of circulatory failure in obstructive jaundice were studied in the 3-day bile duct-ligated (BDL) rat using three different techniques to measure cardiac function and beta-adrenoceptor activity, number, and affinity. The techniques were the pithed rat preparation, the isolated working heart preparation, and a competitive radioligand binding assay for beta-adrenoceptors. The results of these experiments were compared with those obtained in 3-day bile duct-manipulated (sham operated; SO) rats

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17

Rajapaksha, Lahiru Theekshana Weerasinghe, Sugandima Mihirani Vidanagamachchi, Sampath Gunawardena, and Vajira Thambawita. "An Open-Access Dataset of Hospitalized Cardiac-Arrest Patients: Machine-Learning-Based Predictions Using Clinical Documentation." BioMedInformatics 4, no. 1 (2023): 34–49. http://dx.doi.org/10.3390/biomedinformatics4010003.

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Cardiac arrest is a sudden loss of heart function with serious consequences. In developing countries, healthcare professionals use clinical documentation to track patient information. These data are used to predict the development of cardiac arrest. We published a dataset through open access to advance the research domain. While using this dataset, our work revolved around generating and utilizing synthetic data by harnessing the potential of synthetic data vaults. We conducted a series of experiments by employing state-of-the-art machine-learning techniques. These experiments aimed to assess

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18

Svorc, Pavol. "Acknowledging Sex Differences in In vivo Experiments: Dilemma." Trends in Anatomy and Physiology 4, no. 1 (2021): 1–3. http://dx.doi.org/10.24966/tap-7752/100012.

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The role of the Autonomic Nervous System (ANS) and its organ-specific functions are largely elucidated. Heart Rate Variability (HRV) analysis is a popular tool for the assessment of autonomic cardiac control. Heart rate and its changes are a sensitive indicator of ANS function, therefore cardiovascular autonomic regulation is considered to be the most reliable indicator of ANS activity and status. HRV refers to beat to beat variation in the heart rate that quantifies the interplay between sympathetic and parasympathetic activity of the ANS. Although patterns of HRV hold considerable promise fo

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19

Dick, W. F., E. Traub, K. Engels, and K. H. Lindner. "Animal Experiments on the Effects of PEEP and Different Ventilation-Compression Ratios in Neonatal Cardiopulmonary Resuscitation." Prehospital and Disaster Medicine 1, S1 (1985): 214–15. http://dx.doi.org/10.1017/s1049023x00044526.

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The physiological range of respiratory rates and heart rates in neonates is approximately 40 per min and 120 per min, respectively, which yields a theoretical ventilation-compression ratio of 1:3ratherthan 1:5.Thirty-six anesthetized pigs with an average body weight of 4–5 kg were used in the study. After establishing a steady state by artificial ventilation with 100% oxygen, a cardiac arrest was induced by an intravenous injection of potassium chloride. Following the cardiac arrest, the animals were resuscitated with ventilation rates of 30 and 40 per min, respectively, while external cardiac

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20

Horackova, M., and J. A. Armour. "ANG II modifies cardiomyocyte function via extracardiac and intracardiac neurons: in situ and in vitro studies." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 3 (1997): R766—R775. http://dx.doi.org/10.1152/ajpregu.1997.272.3.r766.

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To determine whether angiotensin II (ANG II) affects cardiac performance via neurons in intrathoracic cardiac ganglia, studies were performed on anesthetized dogs. To exclude possible vascular regulatory effects of ANG II, experiments were also performed using long-term cultures of adult guinea pig ventricular cardiomyocytes with or without intrathoracic neurons. 1) In in situ experiments in 10 anesthetized dogs, cardiac augmentation occurred when ANG II (10 microl or 0.1 ml; 10-100 microM) was administered into limited loci within acutely decentralized stellate or middle cervical ganglia that

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21

Hasegawa, Tomomi, Koichiro Iwanaga, Donald E. Hultquist, Hui Liao, Scott H. Visovatti, and David J. Pinsky. "Suppression of nitrosative and oxidative stress to reduce cardiac allograft vasculopathy." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 4 (2009): H1007—H1016. http://dx.doi.org/10.1152/ajpheart.00498.2008.

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Oxidant injury occurs when an organ is severed from its native blood supply and then reperfused and continues during subsequent periods of immune attack. Experiments here test the hypothesis that an antioxidant given only in the peri-reperfusion period protects against not only oxidative but also nitrosative stress, leading to reduced vasculopathy long after cardiac allotransplantation. Experiments were performed using a murine heterotopic cardiac transplantation model. An antioxidant, in the form of intraperitoneal high-dose riboflavin, was given to recipients during the initial 3 days after

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22

SACHSE, F. B., K. G. GLÄNZEL, and G. SEEMANN. "MODELING OF PROTEIN INTERACTIONS INVOLVED IN CARDIAC TENSION DEVELOPMENT." International Journal of Bifurcation and Chaos 13, no. 12 (2003): 3561–78. http://dx.doi.org/10.1142/s0218127403008855.

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Modeling of protein interactions responsible for cardiac tension development can enhance the understanding of physiological and pathophysiological phenomena of the heart. Principal components of muscular tension development are the proteins actin, myosin, troponin and tropomyosin. The tension is produced by cross-bridge cycling of actin and myosin using adenosine triphosphate as energy source. The cross-bridge cycling is initiated by binding of intracellular calcium to troponin, resulting in configuration changes of tropomyosin. In this work a hybrid model of protein interactions in cardiac te

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23

Corrias, A., X. Jie, L. Romero, et al. "Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368, no. 1921 (2010): 3001–25. http://dx.doi.org/10.1098/rsta.2010.0083.

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In this paper, we illustrate how advanced computational modelling and simulation can be used to investigate drug-induced effects on cardiac electrophysiology and on specific biomarkers of pro-arrhythmic risk. To do so, we first perform a thorough literature review of proposed arrhythmic risk biomarkers from the ionic to the electrocardiogram levels. The review highlights the variety of proposed biomarkers, the complexity of the mechanisms of drug-induced pro-arrhythmia and the existence of significant animal species differences in drug-induced effects on cardiac electrophysiology. Predicting d

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24

Seidenberg, Jemima, Mara Stellato, Amela Hukara, et al. "The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis." International Journal of Molecular Sciences 22, no. 4 (2021): 1861. http://dx.doi.org/10.3390/ijms22041861.

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Background: Pathological activation of cardiac fibroblasts is a key step in development and progression of cardiac fibrosis and heart failure. This process has been associated with enhanced autophagocytosis, but molecular mechanisms remain largely unknown. Methods and Results: Immunohistochemical analysis of endomyocardial biopsies showed increased activation of autophagy in fibrotic hearts of patients with inflammatory cardiomyopathy. In vitro experiments using mouse and human cardiac fibroblasts confirmed that blockade of autophagy with Bafilomycin A1 inhibited fibroblast-to-myofibroblast tr

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25

Watson, P. A., R. Hannan, L. L. Carl, and K. E. Giger. "Contractile activity and passive stretch regulate tubulin mRNA and protein content in cardiac myocytes." American Journal of Physiology-Cell Physiology 271, no. 2 (1996): C684—C689. http://dx.doi.org/10.1152/ajpcell.1996.271.2.c684.

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Accumulation of tubulin protein and an increased array of microtubules have been associated with contractile dysfunction in cardiac myocytes after pressure overload in vivo. Experiments were performed to assess the ability of mechanical stimuli experienced by ventricular cardiac myocytes during the progression of hypertrophic and dilated pathology to increase beta-tubulin production in cultured neonatal rat cardiac myocytes. Results indicate that both contractile activity and load due to passive stretch increase beta-tubulin protein content in neonatal rat cardiac myocytes through accumulation

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26

Rampoldi, Antonio, Rajneesh Jha, Jordan Fite, Gene Boland, and Chunhui Xu. "Cryopreservation and CO2-independent culture of 3D cardiac progenitors for spaceflight experiments." Biomaterials 269 (February 2021): 120673. http://dx.doi.org/10.1016/j.biomaterials.2021.120673.

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27

Stefanie Heyden, Andreas Nagler, Cristóbal Bertoglio, et al. "Material modeling of cardiac valve tissue: Experiments, constitutive analysis and numerical investigation." Journal of Biomechanics 48, no. 16 (2015): 4287–96. http://dx.doi.org/10.1016/j.jbiomech.2015.10.043.

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28

Greillier, Paul, Bénédicte Ankou, Francis Bessière, et al. "Transoesophageal HIFU for cardiac ablation: In-vivo experiments in non-human primates." Journal of the Acoustical Society of America 141, no. 5 (2017): 4013. http://dx.doi.org/10.1121/1.4989221.

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29

Awada, Hassan K., Louis A. Johnson, T. Kevin Hitchens, Lesley M. Foley, and Yadong Wang. "Factorial Design of Experiments to Optimize Multiple Protein Delivery for Cardiac Repair." ACS Biomaterials Science & Engineering 2, no. 5 (2016): 879–86. http://dx.doi.org/10.1021/acsbiomaterials.6b00146.

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30

MALIK, MAREK, and A. JOHN CAMM. "Cardiac Electrophysiological Experiments in Numero, Part III: Simulation of Arrhythmias and Pacing." Pacing and Clinical Electrophysiology 14, no. 12 (1991): 2167–86. http://dx.doi.org/10.1111/j.1540-8159.1991.tb06487.x.

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31

Carusi, Annamaria, Kevin Burrage, and Blanca Rodríguez. "Bridging experiments, models and simulations: an integrative approach to validation in computational cardiac electrophysiology." American Journal of Physiology-Heart and Circulatory Physiology 303, no. 2 (2012): H144—H155. http://dx.doi.org/10.1152/ajpheart.01151.2011.

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Computational models in physiology often integrate functional and structural information from a large range of spatiotemporal scales from the ionic to the whole organ level. Their sophistication raises both expectations and skepticism concerning how computational methods can improve our understanding of living organisms and also how they can reduce, replace, and refine animal experiments. A fundamental requirement to fulfill these expectations and achieve the full potential of computational physiology is a clear understanding of what models represent and how they can be validated. The present

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32

Zhou, Weiguo, Jerrel H. Fontenot, Shi Liu, and Richard H. Kennedy. "Modulation of Cardiac Calcium Channels by Propofol." Anesthesiology 86, no. 3 (1997): 670–75. http://dx.doi.org/10.1097/00000542-199703000-00020.

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Background Propofol elicits a rapid depression of transsarcolemmal Ca2+ influx and myocardial contractility. However, the mechanism underlying this action has not been well described. The present study was designed to test the hypothesis that propofol acts as an antagonist of L-type calcium channels. Methods Experiments monitored effects of propofol on (1) the binding of [3H]nitrendipine (a 1,4-dihydropyridine calcium channel antagonist) to rat myocardial membranes; (2) L-type calcium current (ICa,L) as determined using whole-cell patch-clamp techniques in intact rat cardiomyocytes; and (3) my

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Si, Rui, Qian Zhang, Atsumi Tsuji-Hosokawa, et al. "Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes." Cardiovascular Research 116, no. 6 (2019): 1186–98. http://dx.doi.org/10.1093/cvr/cvz216.

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Abstract Aims We previously reported that increased protein O-GlcNAcylation in diabetic mice led to vascular rarefaction in the heart. In this study, we aimed to investigate whether and how coronary endothelial cell (EC) apoptosis is enhanced by protein O-GlcNAcylation and thus induces coronary microvascular disease (CMD) and subsequent cardiac dysfunction in diabetes. We hypothesize that excessive protein O-GlcNAcylation increases p53 that leads to CMD and reduced cardiac contractility. Methods and results We conducted in vivo functional experiments in control mice, TALLYHO/Jng (TH) mice, a p

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34

Ma, Junjie, Xucheng Zhu, Suryanarayanan Kaushik, et al. "Qualitative and Quantitative Evaluation of a Deep Learning-Based Reconstruction for Accelerated Cardiac Cine Imaging." Bioengineering 12, no. 3 (2025): 231. https://doi.org/10.3390/bioengineering12030231.

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Two-dimensional (2D) cine imaging is essential in routine clinical cardiac MR (CMR) exams for assessing cardiac structure and function. Traditional cine imaging requires patients to hold their breath for extended periods and maintain consistent heartbeats for optimal image quality, which can be challenging for those with impaired breath-holding capacity or irregular heart rhythms. This study aims to systematically assess the performance of a deep learning-based reconstruction (Sonic DL Cine, GE HealthCare, Waukesha, WI, USA) for accelerated cardiac cine acquisition. Multiple retrospective expe

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35

Prandini, Mirto Nelso, Anita L. R. Saldanha, and André Luis Varela Gasparoto. "Induced Hypothermia: From Bench to Bedside in Systemic and Neurological Protection After Resuscitation From Cardiac Arrest." Japan Journal of Clinical & Medical Research 1, no. 2 (2021): 1–5. http://dx.doi.org/10.47363/jjcmr/2021(1)107.

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Introduction: Cardiac arrest outside medical center is a major cause of death. The survival rates ranges from 5 percent to 35 percent. In patients who are initially resuscitated, anoxic neurologic injury is the prime cause of morbidity and mortality, besides hazards in multiple organs as the kidneys, for example. Induced hypothermia has proven to improve the prognosis after resuscitation from cardiac arrest. Objective: To demonstrate in experiments where induced mild hypothermia has been able to reduce ischemic and inflammatory damage in animal’s brains and consequently the multiplicity of the

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36

Carreras, David, Rebecca Martinez-Moreno, Mel·lina Pinsach-Abuin, et al. "Epigenetic Changes Governing Scn5a Expression in Denervated Skeletal Muscle." International Journal of Molecular Sciences 22, no. 5 (2021): 2755. http://dx.doi.org/10.3390/ijms22052755.

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The SCN5A gene encodes the α-subunit of the voltage-gated cardiac sodium channel (NaV1.5), a key player in cardiac action potential depolarization. Genetic variants in protein-coding regions of the human SCN5A have been largely associated with inherited cardiac arrhythmias. Increasing evidence also suggests that aberrant expression of the SCN5A gene could increase susceptibility to arrhythmogenic diseases, but the mechanisms governing SCN5A expression are not yet well understood. To gain insights into the molecular basis of SCN5A gene regulation, we used rat gastrocnemius muscle four days foll

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37

Yatskievych, T. A., A. N. Ladd, and P. B. Antin. "Induction of cardiac myogenesis in avian pregastrula epiblast: the role of the hypoblast and activin." Development 124, no. 13 (1997): 2561–70. http://dx.doi.org/10.1242/dev.124.13.2561.

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An in vitro assay has been developed to investigate tissue interactions regulating myocardial cell specification in birds. Explants from the posterior region of stage XI-XIV blastulas were found to form heart muscle at high frequency with a timing that corresponded to onset of cardiac myocyte differentiation in vivo. Isolation and recombination experiments demonstrated that a signal from the hypoblast was required to induce cardiac myogenesis in the epiblast, and regional differences in epiblast responsiveness and hypoblast inductiveness restrict appearance of cardiac myocytes to the posterior

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Abramov, A. A., V. L. Lakomkin, A. V. Prosvirnin, E. V. Lukoshkova, and V. I. Kapelko. "Mitochondrial Antioxidant Plastomitin Improves Cardiac Function in Doxorubicin-Induced Cardiomyopathy." Kardiologiia 59, no. 6 (2019): 35–41. http://dx.doi.org/10.18087/cardio.2019.6.2649.

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The aim of the study was to ascertain whether the use of plastomitin, the mitochondrial antioxidant, can affect the development of systolic dysfunction that occurs in rats after 4 weeks of doxorubicin treatment (2 mg/kg weekly). Materials and methods. Male Wistar rats weighing 320–380 g were used in this work. Echocardiographic study was carried out using Vevo 1100 with linear probe 13–24 MHz frequency. Results. Echocardiographic study of rats through 8 weeks from the beginning of doxorubicin treatment showed the presence of systolic dysfunction with decrease of ejection fraction of the left v

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Cardinal, René, Pierre Savard, J. Andrew Armour, Réginald Nadeau, D. Leigh Carson, and A. Robert LeBlanc. "Mapping of ventricular tachycardia induced by thoracic neural stimulation in dogs." Canadian Journal of Physiology and Pharmacology 64, no. 4 (1986): 411–18. http://dx.doi.org/10.1139/y86-066.

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To investigate ventricular tachycardias produced in healthy canine myocardium by stimulation of sympathetic ganglia or cardiac nerves, we simultaneously recorded a surface ECG and 63 ventricular electrograms in anesthetized open-chest dogs. Isochronal and isopotential maps were generated off-line by computer. Ventricular tachycardia with uniform beat-to-beat morphology was induced in 13 or 22 dogs by electrical stimulation of the left stellate ganglion (five experiments), the left middle cervical ganglion (four experiments), the left caudal pole cardiopulmonary nerve (two experiments), or the

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40

Zou, Xianghua, Bin Li, Cong Wang, Jian Chang, and Yanbin Li. "Simulation and Experiment of Cardiopulmonary Resuscitation Robot." Journal of Physics: Conference Series 2493, no. 1 (2023): 012017. http://dx.doi.org/10.1088/1742-6596/2493/1/012017.

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Abstract Aiming at the emergence of patients with outdoor cardiac arrest, to strive for more golden rescue time, a robot suitable for the rescue of patients with outdoor cardiac arrest is proposed. Combined with the medical research on the human thorax, the dynamic model of the human thorax is established, the kinematics and dynamics of the end effector mechanism are analyzed, and the robot is simulated for cardiopulmonary resuscitation in the human thorax with Adams software. The relationship between the stroke, speed, acceleration, driving torque, and time of the end effector is obtained. Se

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41

Jordan, Peter N., and David J. Christini. "Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: implications for repolarization alternans." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 4 (2007): H2109—H2118. http://dx.doi.org/10.1152/ajpheart.00609.2007.

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Experiments have provided suggestive but inconclusive insights into the relative contributions of transmembrane voltage and intracellular calcium handling to the development of cardiac electrical instabilities such as repolarization alternans. In this study, we applied a novel combination of techniques (action potential voltage clamping, calcium-transient clamping, and stability analysis) to cardiac cell models to more clearly determine the roles that voltage- and calcium-dependent coupling play in regulating action potential stability and the development of alternans subsequent to the loss of

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42

Xiu, Xianchao, and Lingchen Kong. "Rank-One and Transformed Sparse Decomposition for Dynamic Cardiac MRI." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/169317.

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It is challenging and inspiring for us to achieve high spatiotemporal resolutions in dynamic cardiac magnetic resonance imaging (MRI). In this paper, we introduce two novel models and algorithms to reconstruct dynamic cardiac MRI data from under-sampledk-tspace data. In contrast to classical low-rank and sparse model, we use rank-one and transformed sparse model to exploit the correlations in the dataset. In addition, we propose projected alternative direction method (PADM) and alternative hard thresholding method (AHTM) to solve our proposed models. Numerical experiments of cardiac perfusion

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Pahor, Marco, Marco Di Gennaro, Roberto Bernabei, Giovanni Gambassi Jr., and Pierugo Carbonin. "Programmed electrical stimulation-induced arrhythmias in isolated hearts from adult and senescent rats." Canadian Journal of Physiology and Pharmacology 67, no. 5 (1989): 472–76. http://dx.doi.org/10.1139/y89-075.

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In isolated hearts from normal rats, we previously demonstrated an age-related increase of spontaneous ventricular arrhythmias. The aim of the present experiments was to test the possible effect of aging on ventricular arrhythmias induced by programmed electrical stimulation. Experiments were performed in isolated cardiac preparations of 6- and 24-month-old normal Wistar rat hearts. Programmed electrical stimulation (single or double premature stimuli following a stimuli train) was tested in isolated Langendorff perfused hearts during control perfusion, after left anterior descending coronary

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Lehman, John J., Sihem Boudina, Natasha Hausler Banke та ін. "The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis". American Journal of Physiology-Heart and Circulatory Physiology 295, № 1 (2008): H185—H196. http://dx.doi.org/10.1152/ajpheart.00081.2008.

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High-capacity mitochondrial ATP production is essential for normal function of the adult heart, and evidence is emerging that mitochondrial derangements occur in common myocardial diseases. Previous overexpression studies have shown that the inducible transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α is capable of activating postnatal cardiac myocyte mitochondrial biogenesis. Recently, we generated mice deficient in PGC-1α (PGC-1α−/− mice), which survive with modestly blunted postnatal cardiac growth. To determine if PGC-1α is essential for normal ca

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Tabata, Tomotsugu, Richard A. Grimm, Junko Asada, et al. "Determinants of LV diastolic function during atrial fibrillation: beat-to-beat analysis in acute dog experiments." American Journal of Physiology-Heart and Circulatory Physiology 286, no. 1 (2004): H145—H152. http://dx.doi.org/10.1152/ajpheart.00588.2003.

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Left ventricular (LV) diastolic function during atrial fibrillation (AF) remains poorly understood due to the complex interaction of factors and beat-to-beat variability. The purpose of the present study was to elucidate the physiological determinants of beat-to-beat changes in LV diastolic function during AF. The RR intervals preceding a given cardiac beat were measured from the right ventricular electrogram in 12 healthy open-chest mongrel dogs during AF. Doppler echocardiography and LV pressure and volume beat-to-beat analyses were performed. The LV filling time (FT) and early diastolic mit

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Sigit, Riyanto, Ali Ridho Barakbah, Indra Adji Sulistijono, and Adam Shidqul Aziz. "Automatic Cardiac Segmentation Using Triangle and Optical Flow." Indonesian Journal of Electrical Engineering and Computer Science 8, no. 2 (2017): 315. http://dx.doi.org/10.11591/ijeecs.v8.i2.pp315-326.

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Cardiac function assessment plays an important role in daily cardiology and ultrasound. Full automatic cardiac segmentation is a challenging study because cardiac ultrasound imaging has low contrast and irregular moves. In this research, full automatic cardiac segmentation for cardiac diseases is presented. The technique used Initial Center Boundary, Pre-processing, Triangle Segmentation and Optical Flow. The first step is determining the initial center boundary. The second step is using Pre-processing to eliminate noise. The third step is Triangle Segmentation to detect cardiac boundary and r

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Gao, Rongrong, Lijun Wang, Yihua Bei, et al. "Long Noncoding RNA Cardiac Physiological Hypertrophy–Associated Regulator Induces Cardiac Physiological Hypertrophy and Promotes Functional Recovery After Myocardial Ischemia-Reperfusion Injury." Circulation 144, no. 4 (2021): 303–17. http://dx.doi.org/10.1161/circulationaha.120.050446.

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Background: The benefits of exercise training in the cardiovascular system have been well accepted; however, the underlying mechanism remains to be explored. Here, we report the initial functional characterization of an exercise-induced cardiac physiological hypertrophy–associated novel long noncoding RNA (lncRNA). Methods: Using lncRNA microarray profiling, we identified lncRNAs in contributing the modulation of exercise-induced cardiac growth that we termed cardiac physiological hypertrophy–associated regulator (CPhar). Mice with adeno-associated virus serotype 9 driving CPhar overexpression

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Le Guennec, Jean-Yves, Christophe Vandier, and Gilles Bedfer. "SIMPLE EXPERIMENTS TO UNDERSTAND THE IONIC ORIGINS AND CHARACTERISTICS OF THE VENTRICULAR CARDIAC ACTION POTENTIAL." Advances in Physiology Education 26, no. 3 (2002): 185–94. http://dx.doi.org/10.1152/advan.00061.2001.

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Electrophysiological experiments are helpful for students to understand the role of electrical activity in heart function. Papillary muscle, which belongs to the ventricle, offers the advantage of being easily studied using glass microelectrodes. In addition, there is commercially available software that simulates ventricular electrical activity and can help overcome some difficulties, such as voltage clamp experiments, which need expensive apparatus when used for studies on living preparations. Here, we present a class practical session that is taken by undergraduate students at our Universit

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Lindsey, Merry L., Lisandra E. de Castro Brás, Kristine Y. DeLeon-Pennell, et al. "Reperfused vs. nonreperfused myocardial infarction: when to use which model." American Journal of Physiology-Heart and Circulatory Physiology 321, no. 1 (2021): H208—H213. http://dx.doi.org/10.1152/ajpheart.00234.2021.

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There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This Perspectives summarizes the consensus of the authors regarding how to select the optimum model for your experiments and is a part of ongoing efforts to establish rigor and reproducibility in cardiac physiology research.

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Fang, H. R., T. Tang, X. M. Zhang, Zhuo Zhuang, Wei Yang, and Ying Zhao. "Finite Element Modeling of Cardiac Pacing/Defibrillation Lead Interaction with Heart." Key Engineering Materials 306-308 (March 2006): 1271–76. http://dx.doi.org/10.4028/www.scientific.net/kem.306-308.1271.

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The hyperelastic constitutive model of cardiac muscle is developed based on the animal surgical operation and mechanical experiments from the heart of the dogs, and the relaxation phenomena is also studied based on the Hill three elements model which is viscoelastic. Some numerical simulations are presented by finite element for the cardiac pacing/defibrillation lead interaction with muscles of the heart.

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