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Relevant bibliographies by topics / Cephalosporin C

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Academic literature on the topic 'Cephalosporin C'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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Journal articles on the topic "Cephalosporin C"

1

Hardianto, Dudi, Bima Wedana Isdiyono, and Fransiskus Xaverius Ivan. "BIOKONVERSI SEFALOSPORIN C MENJADI ASAM 7-AMINOSEFALOSPORANAT DENGAN SEFALOSPORIN ASILASE." Jurnal Bioteknologi & Biosains Indonesia (JBBI) 3, no. 2 (2016): 89. http://dx.doi.org/10.29122/jbbi.v3i2.139.

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Cephalosporins are the most widely used class of β-lactam antibiotic in the world and clinically active against gram positive and gram negative bacteria. Cephalosporin C (CPC) is naturally produced by fungus Cephalosporiun acremonium. CPC has moderate antibacterial activity with minimum inhibitory concentration values of 25-100 µg/mL and 12-25 µg/mL for gram-positive and for gram-negative bacteria, respectively. CPC can be converted into 7-aminocephalosporonic acid (7-ACA) as intermediate compound for cephalosporin derivatives by two-steps or one-step enzymatic method. Two-step enzymatic metho

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2

Xiao, X., S. Wolfe та A. L. Demain. "Purification and characterization of cephalosporin 7α-hydroxylase from Streptomyces clavuligerus". Biochemical Journal 280, № 2 (1991): 471–74. http://dx.doi.org/10.1042/bj2800471.

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Cephalosporin 7 alpha-hydroxylase, which catalyses the conversion of cephalosporins into their 7 alpha-hydroxy derivatives, was purified nearly 390-fold from Streptomyces clavuligerus through ion-exchange chromatography, (NH4)2SO4 fractionation, gel filtration and dye chromatography, with the use of h.p.l.c. to monitor enzyme activity. The nearly pure enzyme migrates as a single major band, with an Mr of 32,000 in SDS/PAGE. Its optimum pH is in the range 7.3-7.7. Under our conditions the reaction was fastest at temperatures in the range 20-30 degrees C. The Km for cephalosporin C is 0.72 mM, a

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3

Nour El-Din,, Mona, M. Saleh, M. Rasmy, and G. Ibrahim. "ANTIMICROBIAL EFFECT OF CEPHALOSPORIN-C PRODUCED BY Cephalosporium maydis." Journal of Plant Production 26, no. 11 (2001): 6813–23. http://dx.doi.org/10.21608/jpp.2001.257991.

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Balakrishnan, Nataraj, Sadhasivam Ganesan, Padma Rajasekaran, Lingeshwaran Rajendran, Sivaprasad Teddu, and Micheal Durairaaj. "Modified Deacetylcephalosporin C Synthase for the Biotransformation of Semisynthetic Cephalosporins." Applied and Environmental Microbiology 82, no. 13 (2016): 3711–20. http://dx.doi.org/10.1128/aem.00174-16.

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ABSTRACTDeacetylcephalosporin C synthase (DACS), a 2-oxoglutarate-dependent oxygenase synthesized byStreptomyces clavuligerus, transforms an inert methyl group of deacetoxycephalosporin C (DAOC) into an active hydroxyl group of deacetylcephalosporin C (DAC) during the biosynthesis of cephalosporin. It is a step which is chemically difficult to accomplish, but its development by use of an enzymatic method with DACS can facilitate a cost-effective technology for the manufacture of semisynthetic cephalosporin intermediates such as 7-amino-cephalosporanic acid (7ACA) and hydroxymethyl-7-amino-ceph

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5

Braña, Alfredo F., Saul Wolfe, and Arnold L. Demain. "Ammonium repression of cephalosporin production by Streptomyces clavuligerus." Canadian Journal of Microbiology 31, no. 8 (1985): 736–43. http://dx.doi.org/10.1139/m85-138.

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Production of β-lactam antibiotics took place during growth of Streptomyces clavuligerus in chemically defined medium. The specific activities of isopenicillin N synthetase ("cyclase"), isopenicillin N epimerase, and deacetoxycephalosporin C synthetase ("expandase") increased during the exponential phase of growth. Specific cephalosporin productivity during fermentation followed a similar pattern, reaching a maximum near the end of the growth phase and decaying rapidly in the stationary phase. Ammonium chloride depressed cephalosporin production, presumably as a result of repression of cyclase

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6

Botnarciuc, Mihaela, Irina Stan, and Sorina Ispas. "Cephalosporin resistant bacterial strains isolated from respiratory infections." ARS Medica Tomitana 21, no. 1 (2015): 7–11. http://dx.doi.org/10.1515/arsm-2015-0012.

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Abstract Objectives: The objective of the study is the evaluation of the actual resistance to second, third, and fourth generation cephalosporins over bacterial strains isolated from respiratory infections. The main causes for cephalosporin resistance of pathogenic and conditioned pathogen bacteria are: widespread usage, and impair immune response. Materials and methods: The analyzed specimens were throat swabs and sputum, from adult patients. The tests were performed using disk diffusion technique. We tested the following cephalosporin: From second generation: cefuroxime axetil; from third ge

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7

Mustika, Indria Puti, and Ahmad Wibisana. "PERAN MUTASI GEN ACY II TERHADAP PRODUKSI ANTIBIOTIK SEFALOSPORIN." Jurnal Bioteknologi & Biosains Indonesia (JBBI) 4, no. 2 (2017): 96. http://dx.doi.org/10.29122/jbbi.v4i2.2272.

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The Roles of AcyII Gene Mutations for Production of Antibiotics Derived From CephalosporinSemisynthetic antibiotics cephalosporins are widely used to treat infectious diseases, especially those caused by gram-negative bacteria. Various types of semisynthetic antibiotics could be synthesized using 7-aminocephalosporanic acid (7-ACA) as the main raw material. 7-ACA is obtained by conversion of cephalosporin C, either chemically or enzymatically. Converting cephalosporin C to 7-ACA enzymatically in one step involves the cephalosporin acylase enzyme. Currently, all of cefalosporin acylase enzymes

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8

Baldwin, Jack E., Robert M. Adlington, Nicholas P. Crouch, and Christopher J. Schofield. "The enzymatic conversion of exomethylene cephalosporin c into deacetyl cephalosporin c and the role of molecular oxygen in cephalosporin c biosynthesis." Tetrahedron 44, no. 2 (1988): 643–50. http://dx.doi.org/10.1016/s0040-4020(01)85852-x.

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9

Hano, Tadashi, Michiaki Matsumoto, Takaaki Ohtake, and Fumiaki Hori. "Reactive extraction of cephalosporin C." JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 25, no. 3 (1992): 293–97. http://dx.doi.org/10.1252/jcej.25.293.

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10

Atroshenko, Denis L., Mikhail D. Shelomov, Sophia A. Zarubina, et al. "Multipoint TvDAAO Mutants for Cephalosporin C Bioconversion." International Journal of Molecular Sciences 20, no. 18 (2019): 4412. http://dx.doi.org/10.3390/ijms20184412.

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d-amino acid oxidase (DAAO, EC 1.4.3.3) is used in many biotechnological processes. The main industrial application of DAAO is biocatalytic production of 7-aminocephalosporanic acid from cephalosporin C with a two enzymes system. DAAO from the yeast Trigonopsis variabilis (TvDAAO) shows the best catalytic parameters with cephalosporin C among all known DAAOs. We prepared and characterized multipoint TvDAAO mutants to improve their activity towards cephalosporin C and increase stability. All TvDAAO mutants showed better properties in comparison with the wild-type enzyme. The best mutant was TvD

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Dissertations / Theses on the topic "Cephalosporin C"

1

Weisenberger, Klaus. "Downstream processing of cephalosporin c." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330236.

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2

Norman, Elizabeth. "Biochemical genetics of Cephalosporin C production." Thesis, University of Nottingham, 1988. http://eprints.nottingham.ac.uk/14317/.

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The biosynthetic pathway which leads, in Cephalosporium acremonium, to the production of the commercially important β-lactam antibiotic Cephalosporin C (CPC) has been the subject of extensive biochemical studies and is now well characterized. In contrast, genetic analysis in this organism was limited until the application of protoplast fusion techniques facilitated parasexual analysis and allowed a genetic map to be established. (Hamlyn 1982; Hamlyn et al 1985). Subsequently, work leading to our understanding of the genetic basis of the CPC biosynthetic pathway in C. acremonium began. (Perez-M

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3

Yang, Su-an. "Fundamental studies and mathematical modelling of an adsorptive purification process for cephalosporin-C." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265180.

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Takimoto, Akio. "Studies of production of deacetyl 7-aminocephalosporanic acid with recombinant cephalosporin-C deacetylase." Kyoto University, 2004. http://hdl.handle.net/2433/145437.

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Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(農学)<br>乙第11556号<br>論農博第2543号<br>新制||農||901(附属図書館)<br>学位論文||H16||N3979(農学部図書室)<br>22816<br>UT51-2004-T200<br>(主査)教授江﨑信芳, 教授清水昌, 教授加藤暢夫<br>学位規則第4条第2項該当

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Antonio, Tatiana. "Estudo da composição de meios de cultura para a produção de cefamicina C por Streptomuces clavuligerus /." Araraquara : [s.n.], 2007. http://hdl.handle.net/11449/88044.

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Orientador: Maria Lucia Gonsales da Costa Araujo<br>Banca: Oswaldo Garcia Junior<br>Banca: Alberto Colli Baldino Junior<br>Resumo: Os grupos de antibióticos mais importantes clinicamente são os dos b-lactâmicos, aminoglicosídeos e tetraciclinas. Streptomyces clavuligerus produz vários compostos b- lactâmicos, com destaque para os antibióticos envolvidos na rota biossintética da cefalosporina C (penicilina N, deacetoxicefalosporina C e cefamicina C) e o ácido clavulânico (AC) que, embora não tenha atividade biológica significativa, é um potente inibidor de b-lactamases (penicilinases e cefalosp

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Antonio, Tatiana [UNESP]. "Estudo da composição de meios de cultura para a produção de cefamicina C por Streptomuces clavuligerus." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/88044.

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Made available in DSpace on 2014-06-11T19:23:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-12-12Bitstream added on 2014-06-13T19:08:57Z : No. of bitstreams: 1 antonio_t_me_araiq.pdf: 609701 bytes, checksum: da17caf99f88297148973c0dd3d64e83 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Os grupos de antibióticos mais importantes clinicamente são os dos b-lactâmicos, aminoglicosídeos e tetraciclinas. Streptomyces clavuligerus produz vários compostos b- lactâmicos, com destaque para os antibióticos envolvidos na rota biossintética da cefalosporina C

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7

Lejon, Sara. "Evasion and Attack: Structural Studies of a Bacterial Albumin-binding Protein and of a Cephalosporin Biosynthetic Enzyme." Doctoral thesis, Uppsala : University Library Universitetsbiblioteket, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8399.

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8

Seidel, Guido. "Kultivierungen mit einem Hochleistungsstamm von Acremonium chrysogenum in komplexen und synthetischen Medien Strategien zur Produktivitätssteigerung unter Berücksichtigung der Enzymaktivitäten der Cephalosporin-C-Biosynthese /." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=962098469.

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9

Pereira, Inês Antunes Cardoso. "Studies on deacetoxy/deacetylcephalosporin C synthase." Thesis, University of Oxford, 1993. http://ora.ox.ac.uk/objects/uuid:d00c6130-a9ec-44f8-a1f5-0465dbaeb4f9.

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This thesis describes an investigation of the mechanism of the bifunctional, a-ketoglutarate dependent dioxygenase, deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS), which catalyses the ring-expansion of penicillin N to deacetoxycephalosporin C (DAOC) and the hydroxylation of this to deacetylcephalosporin C (DAC). The conversion of the unnatural substrate 3-exomethylene cephalosporin C by DAOC/DACS has been investigated in detail. A new metabolite was isolated from incubations of the deuterated [4-<sup>2</sup>H]-3-exomethylene cephalosporin C, and was identified as the 3β-spiroepoxide ce

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10

Andrietta, Maria da Graça Stupiello 1963. "Estudo de meio de cultivo industrial para produção de cefalosporina C por C Cephalosporium acremonium." [s.n.], 1998. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256135.

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Orientador: Gil Eduardo Serra<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-07-23T22:32:53Z (GMT). No. of bitstreams: 1 Andrietta_MariadaGracaStupiello_D.pdf: 4521244 bytes, checksum: 4888bd9055f2da9976f68ec3bac3eafd (MD5) Previous issue date: 1998<br>Resumo: Este trabalho teve como objetivo estudar um meio de cultivo industrial para produção de cefalosporina C, utilizando a linhagem C-1 O de Cephalosporium acremonium (A TCC 11550) em experimentos conduzidos em frascos agitados. Foram testadas diferentes font

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Books on the topic "Cephalosporin C"

1

Radzio, Renate. Heterologe Genexpression in dem Cephalosporin C produzierenden Hyphenpilz Acremonium chrysogenum. J. Cramer, 1997.

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2

Nosek, Jörg. Regulation spezifischer Gene in der Cephalosporin C Biosynthese von Acremonium chrysogenum. J. Cramer, 1997.

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3

Hannover, Universität, ed. Cephalosporin c produktion im rührkessel. 1986.

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Glukoseregulation der Cephalosporin C-biosynthese im Hyphenpilz Acremonium chrysogenum. J. Cramer, 1999.

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Hannover, Universität, ed. Reaktionstechnische Untersuchungen zur Produktion von Cephalosporin C im Mammutsciilaufenreaktor. 1987.

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Der Transkriptionsfaktor CPCR1, ein Regulator der Cephalosporin C-Biosynthesegene in Acremonoim chrysogenum. J. Cramer, 1999.

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7

Hilgendorf, Peter. Cephalosporin C-Fermentation mit Cephalosporium acremonium: Versuche zur Reaktionstechnik und Nachweis des [delta]-(L-[alpha]-Aminoadipyl)-L-cystein-synthetisierenden Enzyms. 1987.

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8

Schmidt, Leopoldo. CΞFALΞXlN ANTlBlOTlCS: A Cephalosporin Antibiotic Used to Treat Infection. Independently Published, 2019.

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9

Heterologe Gene Expression in Dem Cephalosporin C Produzierenden Hyphenpilz Acremonium Chrysogenum (Bibliotheca Mycologica). Gebruder Borntraeger Verlagsbuchhandlung, 1997.

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Regulation Spezifischer Gene in Der Cephalosporin C Biosynthese Von Acremonium Chrysogenum (Bibliotheca Mycologica,). Gebruder Borntraeger Verlagsbuchhandlung, 1997.

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Book chapters on the topic "Cephalosporin C"

1

Schomburg, Dietmar, and Margit Salzmann. "Cephalosporin-C deacetylase." In Enzyme Handbook 3. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76463-9_37.

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Schomburg, Dietmar, and Dörte Stephan. "Cephalosporin-C transaminase." In Enzyme Handbook 13. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-59176-1_109.

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WILDFEUER, M. E. "Approaches to Cephalosporin C Purification from Fermentation Broth." In ACS Symposium Series. American Chemical Society, 1985. http://dx.doi.org/10.1021/bk-1985-0271.ch010.

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Cruz, A. J. G., M. L. G. C. Araujo, R. C. Giordano, and C. O. Hokka. "Phenomenological and Neural-Network Modeling of Cephalosporin C Production Bioprocess." In Biotechnology for Fuels and Chemicals. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-4612-1814-2_53.

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Tollnick, C., G. Seidel, M. Beyer, and K. Schügerl. "Investigations of the Production of Cephalosporin C by Acremonium chrysogenum." In New Trends and Developments in Biochemical Engineering. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/b12439.

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Rowatt, Brian, and David C. Sherrington. "Synthesis and Characterisation of Resin Sorbents For Cephalosporin C Recovery." In Ion Exchange Advances. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2864-3_26.

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7

Casillas, J. L., J. L. Garrido, J. Aracil, M. Martinez, F. Addo-Yobo, and C. N. Kenney. "Batch Stirred Tank Adsorption of Impurity of Cephalosporin C, Desacetylcephalosporin C, Using Modified Amberlite XAD-2 Resin." In Separations for Biotechnology 2. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0783-6_31.

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Ejchart, A., A. Zimniak, I. Oszczapowicz, and H. Szatylowicz. "Relaxation of 13-C Nuclei in Structural Study on Isomers of Cephalosporin Cefuroxime Axetil." In Spectroscopy of Biological Molecules: Modern Trends. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5622-6_288.

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Almeida, Renata M. R. G., Antonio J. G. Cruz, Maria Lucia G. C. Araujo, Roberto C. Giordano, and Carlos O. Hokka. "Modeling and Simulation of Cephalosporin C Production in a Fed-Batch Tower-Type Bioreactor." In Twenty-Second Symposium on Biotechnology for Fuels and Chemicals. Humana Press, 2001. http://dx.doi.org/10.1007/978-1-4612-0217-2_46.

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Seidel, G., C. Tollnick, M. Beyer, and K. Schügerl. "On-line and Off-line Monitoring of the Production of Cephalosporin C by Acremonium chrysogenum." In Bioanalysis and Biosensors for Bioprocess Monitoring. Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/3-540-48773-5_4.

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Conference papers on the topic "Cephalosporin C"

1

Shearer, M., K. Andrassy, H. Bechtold, P. McCarthy, J. Koderisch, and H. Koderisch. "CEPHALOSPORIN-INDUCED HYPOPROTHROMBINAEMIA: RELATION TO CEPHALOSPORIN SIDE CHAIN, VITAMIN K METABOLISM AND VITAMIN K STATUS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643076.

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An increased incidence of bleeding episodes due to hypopro-thrombinaemia has been associated with several cephalosporins especially those which contain an N-methyl-thio-tetrazole (NMTT) side chain. To study the etiology of cephalosporin-induced hypo-prothrombinaemia in the clinical situation we have investigated the ability of different cephalosporins to alter the metabolism of vitamin K and the relationship between hypoprothrombinaemia and vitamin K status as assessed from plasma levels of vitamin K. Cephalosporins containing an NMTT side chain (latamoxef, cefmenoxime, cefoperazone, cefotetan

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