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Dissertations / Theses on the topic 'Cephalosporin C'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Weisenberger, Klaus. "Downstream processing of cephalosporin c." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330236.

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2

Norman, Elizabeth. "Biochemical genetics of Cephalosporin C production." Thesis, University of Nottingham, 1988. http://eprints.nottingham.ac.uk/14317/.

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The biosynthetic pathway which leads, in Cephalosporium acremonium, to the production of the commercially important β-lactam antibiotic Cephalosporin C (CPC) has been the subject of extensive biochemical studies and is now well characterized. In contrast, genetic analysis in this organism was limited until the application of protoplast fusion techniques facilitated parasexual analysis and allowed a genetic map to be established. (Hamlyn 1982; Hamlyn et al 1985). Subsequently, work leading to our understanding of the genetic basis of the CPC biosynthetic pathway in C. acremonium began. (Perez-M

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3

Yang, Su-an. "Fundamental studies and mathematical modelling of an adsorptive purification process for cephalosporin-C." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265180.

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4

Takimoto, Akio. "Studies of production of deacetyl 7-aminocephalosporanic acid with recombinant cephalosporin-C deacetylase." Kyoto University, 2004. http://hdl.handle.net/2433/145437.

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Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(農学)<br>乙第11556号<br>論農博第2543号<br>新制||農||901(附属図書館)<br>学位論文||H16||N3979(農学部図書室)<br>22816<br>UT51-2004-T200<br>(主査)教授江﨑信芳, 教授清水昌, 教授加藤暢夫<br>学位規則第4条第2項該当

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5

Antonio, Tatiana. "Estudo da composição de meios de cultura para a produção de cefamicina C por Streptomuces clavuligerus /." Araraquara : [s.n.], 2007. http://hdl.handle.net/11449/88044.

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Orientador: Maria Lucia Gonsales da Costa Araujo<br>Banca: Oswaldo Garcia Junior<br>Banca: Alberto Colli Baldino Junior<br>Resumo: Os grupos de antibióticos mais importantes clinicamente são os dos b-lactâmicos, aminoglicosídeos e tetraciclinas. Streptomyces clavuligerus produz vários compostos b- lactâmicos, com destaque para os antibióticos envolvidos na rota biossintética da cefalosporina C (penicilina N, deacetoxicefalosporina C e cefamicina C) e o ácido clavulânico (AC) que, embora não tenha atividade biológica significativa, é um potente inibidor de b-lactamases (penicilinases e cefalosp

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6

Antonio, Tatiana [UNESP]. "Estudo da composição de meios de cultura para a produção de cefamicina C por Streptomuces clavuligerus." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/88044.

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Made available in DSpace on 2014-06-11T19:23:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-12-12Bitstream added on 2014-06-13T19:08:57Z : No. of bitstreams: 1 antonio_t_me_araiq.pdf: 609701 bytes, checksum: da17caf99f88297148973c0dd3d64e83 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Os grupos de antibióticos mais importantes clinicamente são os dos b-lactâmicos, aminoglicosídeos e tetraciclinas. Streptomyces clavuligerus produz vários compostos b- lactâmicos, com destaque para os antibióticos envolvidos na rota biossintética da cefalosporina C

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7

Lejon, Sara. "Evasion and Attack: Structural Studies of a Bacterial Albumin-binding Protein and of a Cephalosporin Biosynthetic Enzyme." Doctoral thesis, Uppsala : University Library Universitetsbiblioteket, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8399.

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8

Seidel, Guido. "Kultivierungen mit einem Hochleistungsstamm von Acremonium chrysogenum in komplexen und synthetischen Medien Strategien zur Produktivitätssteigerung unter Berücksichtigung der Enzymaktivitäten der Cephalosporin-C-Biosynthese /." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=962098469.

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9

Pereira, Inês Antunes Cardoso. "Studies on deacetoxy/deacetylcephalosporin C synthase." Thesis, University of Oxford, 1993. http://ora.ox.ac.uk/objects/uuid:d00c6130-a9ec-44f8-a1f5-0465dbaeb4f9.

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This thesis describes an investigation of the mechanism of the bifunctional, a-ketoglutarate dependent dioxygenase, deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS), which catalyses the ring-expansion of penicillin N to deacetoxycephalosporin C (DAOC) and the hydroxylation of this to deacetylcephalosporin C (DAC). The conversion of the unnatural substrate 3-exomethylene cephalosporin C by DAOC/DACS has been investigated in detail. A new metabolite was isolated from incubations of the deuterated [4-<sup>2</sup>H]-3-exomethylene cephalosporin C, and was identified as the 3β-spiroepoxide ce

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10

Andrietta, Maria da Graça Stupiello 1963. "Estudo de meio de cultivo industrial para produção de cefalosporina C por C Cephalosporium acremonium." [s.n.], 1998. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256135.

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Orientador: Gil Eduardo Serra<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-07-23T22:32:53Z (GMT). No. of bitstreams: 1 Andrietta_MariadaGracaStupiello_D.pdf: 4521244 bytes, checksum: 4888bd9055f2da9976f68ec3bac3eafd (MD5) Previous issue date: 1998<br>Resumo: Este trabalho teve como objetivo estudar um meio de cultivo industrial para produção de cefalosporina C, utilizando a linhagem C-1 O de Cephalosporium acremonium (A TCC 11550) em experimentos conduzidos em frascos agitados. Foram testadas diferentes font

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11

Crouch, Nicholas. "The mechanism of the enzymatic ring expansion of penicillin N to deacetoxycephalosporin C." Thesis, University of Oxford, 1988. http://ora.ox.ac.uk/objects/uuid:de3e54eb-b4b5-4673-a863-3c094cc1456d.

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The order of events in the Deacetoxycephalosporin C/Deacetylcephalosporrn C Synthetase (DAOC/DAC Synthetase) catalysed ring expansion of penicillin N to deacetoxycephalosporin C has been investigated by the use of labelled/unlabelled penicillin N mixed competitive kinetic isotope effect experiments, in which the labelled penicillin N substrates were either labelled in the pro <strong>R</strong>- and pro <strong>S</strong>-methyl groups or at C-3. In addition, to assisting in the determination of the position of the first irreversible event in this reaction, deuteration at C-3 gave rise to a bi

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12

Shallouf, Mohamed Abdusalam. "Identification and characterisation of cephalosporins and carbapenem-resistant Klebsiella pneumoniae isolates from Misrata, Libya." University of the Western Cape, 2018. http://hdl.handle.net/11394/6512.

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Philosophiae Doctor - PhD<br>Background: Extended-spectrum beta-lactamase-producing (ESBL) and carbapenemaseproducing Gram-negative bacilli showing resistance to cephalosporins and carbapenems respectively, have been reported from several countries globally and recently among Libyan combatants who have been transferred to European countries for advanced medical care. However, there is a lack of data about their presence in Misrata and in Libya in general. This is the first documented study aimed at investigating the prevalence and resistance mechanisms of ESBL and carbapenemase-producing

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13

Mackenzie, Alasdair. "Studies on the biosynthetic pathways of clavulanic acid and cephamycin C in Streptomyces clavuligerus /." Uppsala : Department of Molecular Biology, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200719.pdf.

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14

Ferreira, Amauri Alves. "Abordagem estatística e computacional na otimização de meios de cultura para produção de antibióticos: o caso da cefalosporina C." Universidade Federal de São Carlos, 2003. https://repositorio.ufscar.br/handle/ufscar/3894.

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Made available in DSpace on 2016-06-02T19:55:29Z (GMT). No. of bitstreams: 1 DoutAAF.pdf: 3275307 bytes, checksum: f45ed0ce056382979fefde457b9cfe5f (MD5) Previous issue date: 2003-10-10<br>The scope of the current work was to investigate the effect of glucose, amonium acetate, DL-methionine, phosphorus, oleic acid and salt solution on the maximum specific growth rate (µmax), as well as the effect of sucrose and DL-methionine on the specific cefalosporin C production rate (µp), by Cephalosporium acremonium ATCC 48272, using factorial design and response surface techniques. The initial medium

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15

Yang, Wu-Yung, and 楊武勇. "Extraction of Cephalosporin C from Whole Broth and Separation of Desacetyl Cephalosporin C by Aqueous Two Phase Partition." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/13348546118231388595.

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16

"Two-step bioengineered enzyme conversion of cephalosporin C to 7-aminocephalosporanic acid." 2004. http://library.cuhk.edu.hk/record=b6073728.

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Yap Hong Kin.<br>"April 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 102-116)<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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17

郭仲達. "Investigation on Optimal Operating Condition for Cephalosporin C Production by Batch Fermentation." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/30127114769352657247.

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碩士<br>明新科技大學<br>化學工程研究所<br>96<br>This study, at first, investigated the morphology evolution of the aerobic pure culture Acremonium chrysogenum (ATCC 48272), by using five different kinds and concentrations of culture media with/without an inducer. The observation shows that the methiolene-containing media has the best inducing effect of culture mutation. Under which A. chrysogenum swelled up in the beginning 6 to 8 hours of the cultivation, and new spores were secreted from parts of the microorganism. Second, the experiments were carried out to investigate the influence of various operati

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18

LIN, PO-TS'UN, and 林柏村. "Separation of mammal cells and purification of Cephalosporin C by Aqueous two phase and Counter Current Chromatography." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/81406967340422344829.

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19

Amatya, Rameshwari. "Multi-class, multi residue method for determination of penicillins, cephalosporins and quinolones in cow milk and validation in accordance with Commission Decision 2002/657/E C." Master's thesis, 2010. http://hdl.handle.net/10400.1/10746.

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The method was developed to determine simultaneously 19 drugs of three classes (seven Penicillins and Cephalosporins, and five Quinolones) regulated by European legislation 2377/90/EC in cow milk using LC-MS/MS. To make the sample preparation as simple as possible deproteinization step using organic solvent was eliminated. SPE clean up and concentration was done using OASIS HLB cartridge. The separation of 19 antibiotics was achieved in 11 minutes using C8 column with gradient elution. MS data was acquired on MRM mode with two transitions for each compound. Validation procedure was cond

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20

Seidel, Guido [Verfasser]. "Kultivierungen mit einem Hochleistungsstamm von Acremonium chrysogenum in komplexen und synthetischen Medien : Strategien zur Produktivitätssteigerung unter Berücksichtigung der Enzymaktivitäten der Cephalosporin-C-Biosynthese / von Guido Seidel." 1999. http://d-nb.info/962098469/34.

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