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Relevant bibliographies by topics / Corneal keratoconus

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Academic literature on the topic 'Corneal keratoconus'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Corneal keratoconus"

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Huseynli, Samira, José Salgado-Borges, and Jorge L. Alio. "Comparative evaluation of Scheimpflug tomography parameters between thin non-keratoconic, subclinical keratoconic, and mild keratoconic corneas." European Journal of Ophthalmology 28, no. 5 (2018): 521–34. http://dx.doi.org/10.1177/1120672118760146.

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Purpose: To evaluate and compare the topographic and topometric parameters, thickness profile data, and data from enhanced elevation maps of thin non-keratoconic, subclinical keratoconic, and mild keratoconic corneas with the Pentacam Scheimpflug corneal tomography and to study the usefulness of different parameters to differentiate keratoconus from topographically normal thin corneas. Methods: The study included 30 eyes with subclinical keratoconus, 30 eyes with mild-stage keratoconus, and 54 healthy eyes with minimal pachymetry ≤500 µm, with a mean age of 21.19 ± 2.97, 21.75 ± 1.93, and 21.5

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Tian, Lei, Yi-Fei Huang, Li-Qiang Wang, et al. "Corneal Biomechanical Assessment Using Corneal Visualization Scheimpflug Technology in Keratoconic and Normal Eyes." Journal of Ophthalmology 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/147516.

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Purpose. To compare the corneal biomechanical properties of keratoconic patients and age-matched controls using corneal visualization Scheimpflug technology (Corvis ST).Methods. Sixty keratoconic eyes from 47 keratoconus patients and 60 normal eyes from 60 controls were enrolled in this prospective study. Tomography and biomechanical parameters of all eyes were obtained with the Pentacam and Corvis ST, respectively. Intraocular pressure was measured using a Goldmann applanation tonometer.Results.The tomography and biomechanical parameters of the keratoconic corneas were significantly different

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García, Beatriz, Olivia García-Suárez, Jesús Merayo-Lloves, et al. "Heparanase Overexpresses in Keratoconic Cornea and Tears Depending on the Pathologic Grade." Disease Markers 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/3502386.

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Background. Keratoconus has classically been defined as a noninflammatory disorder, although recent studies show elevated levels of inflammatory markers suggesting that keratoconus could be, at least in part, an inflammatory condition. Heparanase upregulation has been described in multiple inflammatory disorders. In this article, we study the differential expression of heparanase in cornea and tears from keratoconus patients and healthy controls. Methods. A transcriptomic approach was used employing quantitative polymerase chain reaction to analyze the expression of heparanase and heparanase 2

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Varshney, Ankit. "EVALUATION OF ANTERIOR SEGMENT IMAGING TECHNIQUES IN DIAGNOSIS OF KERATOCONUS." Kadakia International Journal of Research in Multidiscipline 1, no. 3 (2014): 16–25. https://doi.org/10.5281/zenodo.13894030.

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Abstract: Keratoconus, which was first described in detail in 1854 (derived from the Greek terms kerato, meaning cornea, and konos meaning cone) is a bilateral, noninflammatory,1 progressive disorder characterized by corneal ectasia, thinning, protrusion and asymmetric corneal degenerative disease that compromises the structural integrity of the collagen matrix within the corneal stroma. The hallmark characteristic is the development of a localized, cone-shaped ectasia (bulge or hernia) that is accompanied by thinning of the stroma in the area of the cone.2,3

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Revta, A. M., A. A. Pikhtulov, N. A. Derevtsova, D. V. Startseva, and D. M. Ugryumova. "Clinical cases of acute keratoconus." Modern technologies in ophtalmology, no. 4 (September 29, 2023): 138–43. http://dx.doi.org/10.25276/2312-4911-2023-4-138-143.

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During the ten-year follow-up period, hydrops corneae was diagnosed in 5 (6 eyes) out of 266 patients (1.8%) with keratoconus. The age of the patients ranged from 14 to 57 years. In 2 patients, acute keratoconus was the first manifestation of corneal ectasia. Decompensation of chronic keratoconus was observed in the period from 1 to 19 years from the onset of the disease. In all patients, autologous blood injection into the anterior chamber in the acute period of the disease made it possible to stop corneal edema and corneal syndrome in a short time. Hemoplombing of the anterior chamber in acu

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Silver, Frederick H., Tanmay Deshmukh, Dominick Benedetto, et al. "The Contribution of the Limbus and Collagen Fibrils to Corneal Biomechanical Properties: Estimation of the Low-Strain In Vivo Elastic Modulus and Tissue Strain." Biomimetics 9, no. 12 (2024): 758. https://doi.org/10.3390/biomimetics9120758.

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We have compared the biomechanical properties of human and porcine corneas using vibrational optical coherence tomography (VOCT). The elastic modulus of the cornea has been previously reported in the literature to vary from about several kPa to more than several GPa based on the results of different techniques. In addition, the formation of corneal cones near the central cornea in keratoconus has been observed in the clinic. Measurements of the resonant frequency and morphology of human and porcine corneas were used to evaluate the role of the limbus in corneal stabilization, the effect of Bow

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Subbot, A. M., Yu M. Efremov, P. S. Timashev, et al. "Biomechanical properties of keratoconus model – corneal fibrocytes cell culture in zinc depleted growth medium." Acta Biomedica Scientifica 10, no. 1 (2025): 179–88. https://doi.org/10.29413/abs.2025-10.1.19.

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Background. Etiology and pathogenesis research of such a corneal disease as keratoconus is rather difficult due to the impossibility to study the underlying ultrastructural and molecular cornea changes in vivo and in animal models.The aim. To evaluate zinc relevance in the biomechanical properties of the corneal stroma – by means of in vitro keratoconus cell model.Materials and methods. In this experimental study, normal and keratoconic cell models of the corneal stroma were exampled – three-dimensional tissue-engineered structures of corneal fibrocytes obtained from healthy donors keratocytes

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Kwok, Sunny, Xueliang Pan, William Liu, Andrew Hendershot, and Jun Liu. "High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade." PLOS ONE 17, no. 7 (2022): e0271749. http://dx.doi.org/10.1371/journal.pone.0271749.

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In vivo biomechanical characterization of the cornea remains a challenge. We have developed a high-frequency ultrasound elastography method, the ocular pulse elastography (OPE), to measure corneal axial displacement (CAD) induced by the ocular pulse. Here we compared CAD and a stiffness index derived from CAD between keratoconus patients and normal controls. We also explored the trend of these parameters with keratoconus grade. Twenty normal subjects and twenty keratoconus patients were recruited in this study. Corneal topography, tomography, intraocular pressure (IOP) and ocular pulse amplitu

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Arnalich-Montiel, Francisco, Carlota Fuente, Clara Auladell, and Sara Ortiz-Toquero. "Detecting True Change in Keratoconus after Intracorneal Ring Segment Implantation." Life 13, no. 4 (2023): 978. http://dx.doi.org/10.3390/life13040978.

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Confirming the progression of keratoconus is of paramount relevance to providing the appropriate treatment. Real change should be considered consistent over time. It must be greater than the variability of the measurement of the device used to monitor the cornea. The present study aimed to assess the intraobserver repeatability and intersession reproducibility of a Scheimpflug camera in measuring corneal parameters in virgin keratoconus and intrastromal corneal ring segments (ICRS) implantation eyes to discriminate real change from measurement noise. Sixty keratoconus and 30 ICRS eyes were inc

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Mamikonyan, V. R., E. E. Kazaryan, E. V. Evdokimova, and M. Jourieh. "Effect of intraocular pressure level on topographic and biomechanical parameters of the cornea in keratoconus." Modern technologies in ophtalmology 60, no. 2 (2025): 281–82. https://doi.org/10.25276/2312-4911-2025-2-281-282.

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Relevance In studying the causes of keratectasia development in keratoconus (KK), the study of the relationship between the strength characteristics of the cornea and the level of intraocular pressure (IOP) remains an urgent task, the balance between which, as is known, ensures the stability of the cornea configuration in the norm [1, 2]. Objective To study changes in the biomechanical and topographic parameters of the cornea at different levels of ophthalmotonus. Material and methods Studies of corneal parameters were conducted under experimental conditions on cadaver eyes with imitation of t

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Dissertations / Theses on the topic "Corneal keratoconus"

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Parkin, Ben. "The role of matrix metalloproteinase-2 and its inhibitors in keratoconus." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343282.

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Mannion, Maria Luisa Simó. "Corneal nerve morphology and function in keratoconus." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493938.

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Keratoconus is a bilateral non-inflammatory corneal ectatic disorder characterised by corneal thinning which leads to distortion and progressive impairmient of vision. There are still many unanswered questions relating to its aetiology, clinical course and the factors affecting its progression. Increased visibility of the corneal nerves appears to be an early sign of the disease and there are reports of reduced corneal sensitivity in keratoconic patients. Early detection of keratoconus is of increasing importance, especially in refractive surgery to avoid the possibility of inducing iatrogenic

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Colling, Amber J. "A comparison of three methods of measuring central corneal thickness in normal and thinned corneas." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1275058650.

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Tang, Maolong. "Corneal mean curvature mapping application in laser refractive surgery /." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1094593446.

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Ferdi, Alexander Charles. "Developing technology to improve health outcomes in corneal disease." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27407.

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Background Modern keratoconus monitoring and management centres around tomography. Large scale studies that inform practice on the natural history of keratoconus were carried out in the 1990s and predate tomography. Natural history studies using tomography are needed to effectively inform current clinical practice. Corneal cross-linking (CXL) is the only treatment that can stabilise keratoconus progression. High quality randomised controlled trials (RCTs) of CXL have been carried out but large scale real-world studies are needed, to provide further evidence of outcomes and safety. Regist

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Beshtawi, Ithar. "The structural and functional effects of corneal collagen cross-linking on human corneal tissue." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-structural-and-functional-effects-of-corneal-collagen-crosslinking-on-human-corneal-tissue(12f210fe-82b6-4855-a3ea-c5abd828642d).html.

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The aim of this project was to analyse the cellular and biomechanical changes after collagen cross-linking (CXL) treatment on postmortem eye-banked human corneas using different UVA intensities and repeated treatments, and to explore the effects of standard collagen cross-linking on keratoconic corneal buttons, in-vitro. Preliminary studies were conducted to assess the feasibility of using eye-banked corneas to assess the effects of collagen cross-linking, and the possibility of applying scanning acoustic microscopy (SAM) to measure the speed of sound/elasticity of corneal tissue. Eye-banked h

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Giacomin, Natalia Torres. "Análise da eficácia e segurança do crosslinking corneano em pacientes com ceratocone avançado." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-09042018-100655/.

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OBEJTIVOS: Analisar a segurança e eficácia da cirurgia de crosslinking (CXL) de córnea em pacientes com ceratocone em estágios avançados após um seguimento de 4 anos. MÉTODOS: Trata-se de um estudo retrospectivo de pacientes com ceratocone avançado em progressão (Estágio 3 e 4 da classificação de Amsler-Krumeich) que foram submetidos a cirurgia de CXL seguindo o protocolo padrão. Os parâmetros examinados foram acuidade visual com (AVCC) e sem (AVSC) correção, valores ceratométricos (média, plana, curva e apical), paquimetria, e contagem de células endoteliais no préoperatório e após 12, 24 e 4

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Haque, Sameena. "In Vivo Imaging of Corneal Conditions using Optical Coherence Tomography." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2976.

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Purposes: To use optical coherence tomography (OCT) to image and quantify the effect of various corneal conditions, in terms of corneal, stromal and epithelial thickness, and light backscatter. To assess the changes caused by overnight orthokeratology (Corneal Refractive Therapy; CRT<sup>TM</sup>) lens wear, keratoconus and laser in-situ keratomileusis (LASIK) refractive surgery, each of which may lead to topographical alterations in corneal thickness either by temporary moulding, degeneration, or permanent laser ablation, respectively. <br /><br /> Methods: Topographical thickness of

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Väisänen, T. (Timo). "Cellular localisation of type XIII collagen, and its induced expression in human neoplasias and corneal diseases." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514279107.

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Abstract Type XIII collagen belongs to the group of transmembrane collagens. In this thesis the plasma membrane localisation and function of type XIII collagen have been studied using cell biological methods. Type XIII collagen was found to reside in focal adhesions. It appeared in these structures at a very early stage of their assembly and disappeared from them concurrently with focal adhesion proteins talin and vinculin. Insect cells expressing type XIII collagen showed an enhanced adhesion to certain matrix components. These localisation and adhesion data suggested that the function of ty

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Motta, Lorenzo. "Confronto dei risultati visivi e topografici in pazienti con cheratocono sottoposti a cross-linking corneale: tecnica tradizionale Vs transepiteliale." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1006.

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ABSTRACT Obiettivo. Confronto dei risultati visivi e topografici in pazienti con cheratocono in evoluzione, sottoposti a cross-linking corneale (CCL) con procedura epi-off ed epi-on. Materiali e metodi. 72 pazienti; 36 tecnica standard e 36 tecnica transepiteliale, da gennaio 2010 a luglio 2011. Pachimetria > 400 ìm. Follow-up dopo trattamento (1,3 e 6 mesi) eseguito con: visus naturale e corretto, refrazione, biomicroscopia alla lampada a fessura, topografia corneale. Risultati. 36 trattati con CCL standard dopo 6 mesi si dimostra riduzione del Kmax di 2 D e aumento visus di 3/10. Complicanze

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Books on the topic "Corneal keratoconus"

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MD, Wang Ming, and Swartz Tracy Schroeder, eds. Keratoconus & keratoectasia: Prevention, diagnosis, and treatment. SLACK, 2009.

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MD, Wang Ming, and Swartz Tracy Schroeder, eds. Keratoconus & keratoectasia: Prevention, diagnosis, and treatment. SLACK, 2009.

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Wang, Ming. Keratoconus & keratoectasia: Prevention, diagnosis, and treatment. SLACK, 2010.

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Ming, Wang. Keratoconus & keratoectasia: Prevention, diagnosis, and treatment. SLACK, 2010.

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Rabinowitz, Yaron S. Color atlas of corneal topography: Interpreting videokeratography. Igaku-Shoin, 1993.

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Zimmermann, Dieter Robert. Kollagene in normalen und Keratoconus corneae. [s.n.], 1986.

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Naroo, S. A. Corneal topography of a family with known keratoconic patients. UMIST, 1996.

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Alió, Jorge L. Keratoconus: Recent Advances in Diagnosis and Treatment. Springer London, Limited, 2016.

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Alio, Jorge L. Keratoconus: Recent Advances in Diagnosis and Treatment. Springer International Publishing AG, 2016.

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Alió, Jorge L. Keratoconus: Recent Advances in Diagnosis and Treatment. Springer, 2018.

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Book chapters on the topic "Corneal keratoconus"

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Kane, Jack X. "IOL Power Calculation in Keratoconus." In Intraocular Lens Calculations. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-50666-6_66.

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AbstractThe changes in the keratoconic cornea affect multiple aspects of IOL power calculation. The challenges with keratoconus are the corneal power measurement issues, the IOL formula calculation errors, and the difficulty in refraction. The different formulas used in keratoconus cases are compared. The Kane keratoconus formula utilises modified anterior corneal radii of the curvature that better represents the true anterior/posterior ratio in keratoconic eyes while also minimising the effect of corneal power on the ELP calculation. The Barrett True K formula for keratoconus incorporates the

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Hafezi, Farhad, and Emilio A. Torres-Netto. "Corneal Cross-Linking in Ultrathin Corneas." In Keratoconus. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-84506-3_9.

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O’Brart, David. "Corneal Collagen Cross-Linking for Corneal Ectasias." In Keratoconus. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-43881-8_19.

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Jarade, Elias, Maroun Eid, Reeda Bou Said, and Nicole Mechleb. "Extreme Corneal Remodeling Using Intrastromal Corneal Ring Segments." In Keratoconus. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-85361-7_63.

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Mohammadpour, Mehrdad, and Masoud Khorrami-Nejad. "Corneal Cross-Linking." In Keratoconus. CRC Press, 2024. http://dx.doi.org/10.1201/9781003371601-9.

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Coscarelli, Sandro, and Leonardo Torquetti. "Intrastromal Corneal Ring Segment Implantation After Corneal Graft Surgery." In Keratoconus. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-85361-7_55.

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Kling, Sabine, and Farhad Hafezi. "Pediatric Corneal Cross-Linking." In Keratoconus. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-43881-8_21.

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Gemperli, Daniela Barbosa. "Intrastromal Corneal Ring Types." In Keratoconus. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-85361-7_48.

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Soleimani, Mohammad, and Ahmad Masoumi. "Corneal Transplantation in Keratoconus." In Keratoconus. CRC Press, 2024. http://dx.doi.org/10.1201/9781003371601-20.

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Willoughby, Colin E., and Judith Lechner. "Heredity of Keratoconus." In Corneal Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28747-3_3.

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Conference papers on the topic "Corneal keratoconus"

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Bueno, Juan M., Rosa M. Martínez-Ojeda, Enrique J. Fernández, and Patricia Gallego-Muñoz. "Collagen Arrangement Analysis in an In Vivo Corneal Keratoconus Model Imaged with Second Harmonic Imaging Microscopy." In Bio-Optics: Design and Application. Optica Publishing Group, 2025. https://doi.org/10.1364/boda.2025.jw4a.7.

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Second Harmonic Generation (SHG) imaging microscopy has been used to quantify the corneal changes in a collagenase-induced disease progression keratoconus model. Images reveal changes in collagen organization depending on the enzyme concentration and the temporal follow-up.

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Orlandi de Oliveira, Lucas, Felipe Marques de Carvalho Taguchi, Renato Feijó Evangelista, et al. "Keratoconus classification using a novel convolutional neural network architecture and corneal curvature maps." In Applications of Machine Learning 2024, edited by Barath Narayanan, Michael E. Zelinski, Tarek M. Taha, Abdul A. Awwal, and Khan M. Iftekharuddin. SPIE, 2024. http://dx.doi.org/10.1117/12.3029894.

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Molladavoodi, Sara, John B. Medley, Maud Gorbet, and H. J. Kwon. "Mechanotransduction in Corneal Epithelial Cells." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-65406.

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Mechanical properties of the cornea can be affected by diseases such as keratoconus. In keratoconus, a decrease in both thickness and rigidity of the cornea is observed. It is currently not clear whether and how changes in mechanical properties of the cornea are associated with corneal epithelial cell behavior. In the present study, polyacrylamide (PAA) gels with different elastic moduli have been prepared and human corneal epithelial cells (HCECs) have been cultured on them. To investigate the effect that changes in elastic modulus may have on adhesion and migration of corneal epithelial cell

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Karnowski, Karol, Jadwiga Milkiewicz, Ewa Mączyńska-Walkowiak, et al. "OCT-based, multi-spot assessment of corneal biomechanical asymmetries – clinical results." In Optical Coherence Tomography. Optica Publishing Group, 2024. http://dx.doi.org/10.1364/oct.2024.cm1e.4.

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In clinical settings, precise biomechanical assessments of the cornea are crucial for early detection of keratoconus. Our study introduces the clinical application of a breakthrough multi-meridian technique that enables simultaneous 3-D deformation measurements, enhancing the diagnostic capabilities of standard air-puff swept-source OCT systems. By implementing a spatial-depth-encoded multiplexing approach, we achieved a detailed 9-spot measurement of dynamic corneal deformations. The system's efficacy was rigorously evaluated through comprehensive ex vivo trials on porcine eyes and corroborat

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Gairola, Siddhartha, Pallavi Joshi, Anand Balasubramaniam, Kaushik Murali, Nipun Kwatra, and Mohit Jain. "Keratoconus Classifier for Smartphone-based Corneal Topographer." In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2022. http://dx.doi.org/10.1109/embc48229.2022.9871744.

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R, Kanimozhi, and R. Gayathri. "Keratoconus Detection based on Corneal Morpho-Geometric Analysis using Correlation." In 2020 3rd International Conference on Intelligent Sustainable Systems (ICISS). IEEE, 2020. http://dx.doi.org/10.1109/iciss49785.2020.9316066.

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Borgia, Alfredo, Samuel Lawman, Colby Hart, et al. "OP-2 Bowman’s layer in health, keratoconus and other corneal conditions." In Proceedings of the Bowman Club Meeting 2024. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/bmjophth-2024-bcm.2.

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Karnowski, Karol, Jadwiga Milkiewicz, Angela Pachacz, et al. "Clinical prototype of multi-spot air-puff OCT for assessment of corneal biomechanical asymmetry." In Bio-Optics: Design and Application. Optica Publishing Group, 2023. http://dx.doi.org/10.1364/boda.2023.dth2a.1.

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The ability to perform multi-meridian, simultaneous measurements of air-induced corneal deformation is expected to highly improve the accuracy of assessing corneal biomechanics. We propose a simplified method targeting 3-D deformation measurements that could be introduced to any swept-source OCT system. We utilize a spatial-depth-encoded multiplexing technique to provide a 9-spot measurement of the deformation. The method is promising for the assessment of corneal deformation asymmetries in the detection and diagnosis of corneal pathologies such as keratoconus. We present in detail the system

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Al-Aqaba, Mouhamed, and Harminder Dua. "OP-6 The involvement of corneal nerves in the pathogenesis of keratoconus." In Proceedings of the Bowman Club Meeting 2024. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/bmjophth-2024-bcm.6.

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Khan, Altaf, Zoujun Dai, and Thomas J. Royston. "Measuring and Modeling Elastography of Human Cornea Using Scanning Laser Doppler Vibrometry." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14566.

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Our interest is in noninvasively mapping the viscoelastic properties of the human cornea with the aid of a Scanning Laser Doppler Vibrometer (SLDV). Mechanical properties of the cornea can be used to predict early onset of diseases, such as glaucoma and keratoconus. By applying mechanical vibration near the cornea and measuring the dynamic wave propagation across the cornea, an elastographic map can be reconstructed. To effectively reconstruct the data, an appropriate analytical solution is needed to interpret the measured motion; in the present article, we review initial measurements and mode

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