Relevant bibliographies by topics / Cytochrome P-450 Genetic aspects

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  2. Dissertations / Theses
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Academic literature on the topic 'Cytochrome P-450 Genetic aspects'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 January 2023

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Journal articles on the topic "Cytochrome P-450 Genetic aspects"

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Setko, N. P., I. I. Berezin, T. V. Gorohova, A. G. Setko, and S. V. Movergoz. "Molecular-genetic and physiological aspects of workers’ adaptation to industrial environment factors." Sanitarnyj vrač (Sanitary Doctor), no. 9 (September 12, 2022): 673–79. http://dx.doi.org/10.33920/med-08-2209-06.

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Molecular genetic studies of cytochrome P-450 genes and assessment of biological adaptation were carried out in 243 machinists and 202 sinkers employed in underground works. It is shown that the processes of adaptation to the factors of the production environment depend on the functionality of regulatory systems and on the characteristics of genetic associations. It was found that 15.3 % of machinists and 15.3 % of sinkers had a satisfactory level of adaptation, tension and an unsatisfactory level — 38.5 % of machinists and 84.6 % of sinkers; only 46.2 % of machinists failed to adapt. At the s
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Roumak, V. S., N. V. Umnova, and G. A. Sofronov. "MOLECULAR AND CELLULAR ASPECTS OF DIOXIN TOXICITY." Annals of the Russian academy of medical sciences 69, no. 3-4 (August 21, 2015): 77–84. http://dx.doi.org/10.15690/vramn.v69.i3-4.1000.

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Background: Using methods of molecular toxicology to study dioxin intoxication consequences the contribution was accessed of pathologic alterations induced and manifested by specific biomarkers and ecogenetic effects among Vietnamese population living on contaminated territories. The causes of variability in individual sensitivity to toxic activity were also evaluated. Materials and methods: Individual biomedical indices were compared between those living in contaminated with dioxins (n =8142) and control (n =4421) regions. Dioxin concentrations were measured by high resolution chromato-mass s
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Sychev, Dmitry A., Igor N. Sychev, Karin B. Mirzaev, Eric I. Rytkin, Dmitriy V. Ivashchenko, Irina V. Bure, and Vitaliy A. Otdelenov. "Clinical pharmacology technologies for personalization of cardiovascular diseases drug treatment: focus on direct oral anticoagulants." Annals of the Russian academy of medical sciences 74, no. 5 (December 4, 2019): 299–306. http://dx.doi.org/10.15690/vramn1214.

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One of the main causes for adverse reactions development is not taking into account the pharmacokinetics of drugs and the dose. Pharmacokinetics of drugs is mostly defined by the cytochrome P-450 isoenzymes activity, carboxylesterases and many other isoenzymes of drug metabolism, as well as ADME transporters (P-gp etc.) which take part in the process of drug metabolism. The activity of these isoenzymes is defined by the genetic aspects of patients and non-genetic aspects such as comorbidity and drug-drug interactions. The development of complex algorithms for personalization of therapy based o
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Resál, T., K. Farkas, and T. Molnár. "P546 The safety and efficacy of the new-generation budesonide-MMX in the aspect of the cytochrome P-450 enzyme genotype." Journal of Crohn's and Colitis 15, Supplement_1 (May 1, 2021): S516. http://dx.doi.org/10.1093/ecco-jcc/jjab076.667.

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Abstract Background Unlike previous forms of budesonide absorbing from the ileal and ascending colon region, the new-generation budesonide-MMX contains a formula, that allows absorption throughout the whole colon. Budesonide is degraded in the liver by cytochrome P450 3A enzyme, but so far, there is no study examining the relationship between the budesonide’s effect and the enzyme activity. CYP3A5 is absent in 90% of the European/caucasian population due to a functional loss mutation (CYP3A5*3), whereas patients with the wild-type CYP3A5*1 allele may be expected to have increased metabolism. T
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Savelyeva, Marina I., Ekaterina O. Golubenko, Zhannet A. Sozaeva, Irina V. Poddubnaya, and Vera V. Korennaya. "Analysis of the complications of endocrine therapy with tamoxifen in breast cancer: clinical and pharmacogenetic aspects. Prospective pharmacogenetic cohort study." Journal of Modern Oncology 24, no. 3 (November 25, 2022): 361–67. http://dx.doi.org/10.26442/18151434.2022.3.201783.

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Background. Tamoxifen is the drug of choice in ER-positive breast cancer (BC) therapy for perimenopausal women and one of the endocrine therapy options for menopausal patients. The pharmacological effect of tamoxifen can be influenced by the activity of cytochrome P450 (CYP) enzymes and P-glycoprotein transporters (Pg), and the genes encoding them have broad polymorphism, affecting serum concentrations of active metabolites. This article presents the overall results of a prospective population-based study of the clinical significance of genetic polymorphism of tamoxifen metabolic enzymes and t
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Mancilla-Morales, Misael D., Santiago Romero-Fernández, Araceli Contreras-Rodríguez, José J. Flores-Martínez, Víctor Sánchez-Cordero, L. Gerardo Herrera M., María F. López, and Enrico A. Ruiz. "Diverging Genetic Structure of Coexisting Populations of the Black Storm-Petrel and the Least Storm-Petrel in the Gulf of California." Tropical Conservation Science 13 (January 2020): 194008292094917. http://dx.doi.org/10.1177/1940082920949177.

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Estimations on the influence of evolutionary and ecological forces as drivers of population gene diversity and genetic structure have been performed on a growing number of colonial seabirds, but many remain poorly studied. In particular, the population genetic structure of storm-petrels (Hydrobatidae) has been evaluated in only a few of the 24 recognized species. We assessed the genetic diversity and population structure of the Black Storm-Petrel ( Hydrobates melania) and the Least Storm-Petrel ( Hydrobates microsoma) in the Gulf of California. The two species were selected because they are pe
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Setsune, J. I., and D. Dolphin. "Organometallic aspects of cytochrome P-450 metabolism." Canadian Journal of Chemistry 65, no. 3 (March 1, 1987): 459–67. http://dx.doi.org/10.1139/v87-080.

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Carbeneiron porphyrins, (N,Fe)-bridged methyleneiron porphyrins, N-alkyliron porphyrins and σ-alkyliron porphyrins have all been shown to occur in nature and to be interconvertible via redox reactions. The chemistry of the naturally occurring iron porphyrins and model iron, cobalt, and ruthenium porphyrins is reviewed emphasizing their organometallic chemistry.
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Miles, J. S., A. W. Munro, B. N. Rospendowski, W. E. Smith, J. McKnight, and A. J. Thomson. "Domains of the catalytically self-sufficient cytochrome P-450 BM-3. Genetic construction, overexpression, purification and spectroscopic characterization." Biochemical Journal 288, no. 2 (December 1, 1992): 503–9. http://dx.doi.org/10.1042/bj2880503.

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1. The gene CYP102 encoding cytochrome P-450 BM-3 and subgenes encoding the cytochrome P-450 and cytochrome P-450 reductase domains have been cloned in Escherichia coli. 2. The protein products of these genes have been overexpressed and purified to homogeneity. 3. The cytochrome P-450 domain is purified in the ferric low-spin state, but is readily converted into the high-spin state by addition of the substrate palmitate (Ks = 1 microM). The cytochrome P-450 reductase domain readily reduces cytochrome c. Mixing the two domains reconstitutes only about one-thousandth of the fatty acid hydroxylas
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Cusato, J., D. G. Ribaldone, L. Bertani, M. Antonucci, C. Tomasello, G. P. Caviglia, S. Dibetto, M. Mangia, M. Astegiano, and A. D’Avolio. "DOP20 Genetic of vitamin D as predictor of response to adalimumab in Crohn’s Disease." Journal of Crohn's and Colitis 15, Supplement_1 (May 1, 2021): S058—S061. http://dx.doi.org/10.1093/ecco-jcc/jjab073.059.

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Abstract Background Personalised medicine is the direction towards are converging many efforts of experts in inflammatory bowel diseases (IBDs). The advent of biological drugs, with anti-TNF as first category, have revolutionized the managements of these patients. Unfortunately, several unmet needs are present, like an efficacy in about two third of the patients, onset of side effects like infections, paradoxical IMIDs. Being able to treat with these drugs only patients who will respond would avoid losing time without disease improvement and possible side effects. Vitamin D is important for se
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Abdalwahhab, Omir, Asmaa Galal-Khallaf, Samy Abd El-Latif Saber, Alaa GM Osman, and Khaled Mohammed-Geba. "A case study for application of DNA barcoding in identifying species and genetic diversity of fish from the Suez city market, Egypt." Aquatic Living Resources 33 (2020): 11. http://dx.doi.org/10.1051/alr/2020012.

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The Red Sea is one of the key areas of biodiversity in the world. It is a hotspot for speciation and biological invasions. In the current work, a pilot, random sampling trial was carried out to characterize some species in the landings reaching the fish market in Suez city, which is one of the largest fish markets in the Northern Red Sea. Samples of different fish species were subjected to the standard procedures of DNA barcoding, applying the sequencing of the cytochrome oxidase subunit 1 mitochondrial gene (COI). DNA barcoding could successfully identify all the targeted fishes to the specie
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Dissertations / Theses on the topic "Cytochrome P-450 Genetic aspects"

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Hansen, Antony James. "Regulation of the expression of phenobarbital-inducible P450 genes." Title page, contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09PH/09phh2491.pdf.

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Elferink, Lisa Anne. "Characterization of the chicken phenobarbital inducible P450 gene family /." Title page, contents and introduction only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phe39.pdf.

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Gerber, Jaclyn. "Cytochrome P450 polymorphisms : relevance in two South African disease populations." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53345.

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Thesis (MSc)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: With knowledge of the human genome increasing constantly we are continually faced with new and potentially groundbreaking methods for managing, treating and/or identifying diseases and predisposition to diseases and conditions at a genetic level. The human cytochrome P450 (CYP) super-family of genes code for enzymes that can participate in metabolism of drugs and foreign chemicals and in steroid synthesis and metabolism. Mutations in these genes may contribute to clinically relevant diseases. In this study, the effects of
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Wang, Jue. "Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-650-6/.

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Truter, Erika. "Genetic association analysis of polymorphisms in four cytochrome P450 genes, the MDR1 gene and treatment-outcome in Xhosa schizophrenia patients." Thesis, Link to online version, 2007. http://hdl.handle.net/10019/350.

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Gooden, Kyna McCullough Schroeder Jane C. "The relationship of uterine leiomyomata and genetic polymorphisms of Cytochrome P-450 1A1, Cytochrome P-450 1B1, and Catechol-O-Methyltransferase." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,303.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology, School of Public Health." Discipline: Epidemiology; Department/School: Public Health.
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Hu, Yin. "Genetic polymorphism and regulation of cytochrome P450 2E1 /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3690-0.

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McLellan, Roman A. "Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3924-1/.

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Oscarson, Mikael. "Genetic polymorphism of human drug metabolising enzymes : structural and functional studies /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3717-6/.

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Vadlamuri, Satya Vijayanand. "Genetic evaluation of cytochrome-P450 expression in smoking and nonsmoking women." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=1806.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains xiv, 150 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 104-120).
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Books on the topic "Cytochrome P-450 Genetic aspects"

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NATO Advanced Study Institute on Molecular Aspects of Drug Metabolizing Enzymes (1993 Kuşadası, Turkey). Molecular aspects of oxidative drug metabolizing enzymes: Their significance in environmental toxicology, chemical carcinogenesis, and health. Berlin: Springer-Verlag,in cooperation with NATO Scientific Affairs Division, 1995.

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Klaus, Ruckpaul, and Rein Horst, eds. Molecular mechanisms of adrenal steroidogenesis and aspects of regulation and application. London: Taylor & Francis, 1990.

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NATO Advanced Study Institute on Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds (1989 Çeşme, Turkey). Molecular aspects of monooxgenases and bioactivation of toxic compounds. New York: Plenum Press, 1991.

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Schlezinger, Jennifer Joy. Involvement of Cytochrome P450 1A in the toxicity of aryl hydrocarbon receptor agonists: Alteration arachidonic acid metabolism and production of reactive oxygen species. Woods Hole, Mass: Massachusetts Institute of Technology, Woods Hole Oceanographic Institution, Joint Program in Oceanography/Applied Ocean Science and Engineering, 1998.

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Klaus, Ruckpaul, and Rein Horst, eds. Basis and mechanisms of regulation of cytochrome P-450. London: Taylor & Francis, 1989.

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Ruckpaul, Klaus, and Horst Rein. Basis and Mechanisms of Regulation of Cytochrome P-450. de Gruyter GmbH, Walter, 2022.

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Ruckpaul, Klaus, and Horst Rein. Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. de Gruyter GmbH, Walter, 2022.

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Costas, Ioannides, ed. Cytochromes P450: Metabolic and toxicological aspects. Boca Raton: CRC Press, 1996.

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Ioannides, Costas. Cytochromes P450: Metabolic and Toxicological Aspects. Taylor & Francis Group, 1996.

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Cytochromes P450: Metabolic and Toxicological Aspects. CRC, 1996.

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Book chapters on the topic "Cytochrome P-450 Genetic aspects"

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Gillner, Mikael, Jan Bergman, and Jan-Åke Gustafsson. "Xenobiotic Regulation of Cytochrome P-450 Gene Expression." In Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds, 283–92. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-7284-4_16.

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Kalow, W. "Genetic Variation in the Hepatic Cytochrome P-450 System." In Human Genetics, 507–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71635-5_67.

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Fujii-Kuriyama, Yoshiaki, and Osamu Gotoh. "Molecular Biology of Cytochrome P-450: Evolution, Structure and Regulation." In Molecular Aspects of Oxidative Drug Metabolizing Enzymes, 65–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79528-2_4.

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Schenkman, John B., Kenneth E. Thummel, and Leonard V. Favreau. "Physiological and Pathophysiological Alterations in Rat Hepatic Cytochrome P-450+." In Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds, 233–53. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-7284-4_13.

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Bossche, Hugo Vanden, Henri Moereels, and Paul A. J. Janssen. "Role of Cytochrome P - 450 in the Anabolism and Catabolism of Endobiotics." In Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds, 305–30. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-7284-4_18.

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Gillette, James R., and Kenneth Korzekwa. "Overview: Theoretical Aspects of Isotope Effects on the Pattern of Metabolites Formed by Cytochrome P-450." In Advances in Experimental Medicine and Biology, 87–94. Boston, MA: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4684-5877-0_9.

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Philpot, Richard M., Rodolfo Gasser, and Michael P. Lawton. "Primary Structures and Regulation of Cytochrome P-450 Isozymes 2 (IIB) And 5 (IVB) and the Flavin-Containing Monooxygenase in Rabbit Liver and Lung." In Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds, 55–73. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-7284-4_4.

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Usanov, S. A., V. L. Chashchin, and A. A. Akhrem. "Chapter 1. Cytochrome P-450 Dependent Pathways of the Biosynthesis of Steroid Hormones." In Molecular mechanisms of adrenal steroidogenesis and aspects of regulation and application, 1–57. De Gruyter, 1990. http://dx.doi.org/10.1515/9783112563281-002.

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Takemori, S., and S. Kominami. "Chapter 5. Adrenal Microsomal Cytochrome P-450 Dependent Reactions in Steroidogenesis and Biochemical Properties of the Enzymes Involved therein." In Molecular mechanisms of adrenal steroidogenesis and aspects of regulation and application, 153–203. De Gruyter, 1990. http://dx.doi.org/10.1515/9783112563281-005.

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Morishima, Isao. "Pressure Effects on the Ligand-Binding Kinetics for Hemoproteins and Their Site-Directed Mutants." In High Pressure Effects in Molecular Biophysics and Enzymology. Oxford University Press, 1996. http://dx.doi.org/10.1093/oso/9780195097221.003.0016.

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The effects of high pressure up to 1500 bar on the recombination kinetics of oxygen and carbon monoxide (CO) binding to human hemoglobin (intact and isolated chain forms), human myoglobin (and its mutants), and cytochrome P-450 were studied by the use of millisecond and nanosecond laser photolysis. The activation volumes for the binding of CO to the R- and T-quaternary states of hemoglobin (Hbs) were determined to be –9.0 and –31.7 ml, respectively. The characteristic pressure dependence of the activation volume was observed for the R-state Hb but not for the T-state Hb. More detailed studies were made with isolated α- and β-chains of human Hb. The kinetic data were analyzed on the basis of a simple three-species model, which assumes two elementary reaction processes of bond formation and steps of ligand migration. A pressure-dependent activation volume change from negative lo positive values in the bimolecular CO association reaction was observed for both chains. This is attributed to a change of the rate-limiting step from the bond-formation step to the ligandmigration step. High-pressure ligand-binding kinetics were also examined for site-specific mutants of human myoglobin in which some amino acid residues at the heme distal sites, such as Leu 29, Lys 45, Ala 66, and Thr 67, are substituted by others. The pressure dependence of the CO binding rate for the L29 mutants was unusual: a positive value was obtained unexpectedly for overall CO binding. Corresponding to this anomaly was an unusual geometry of the iron-bound CO, which was determined by IR and NMR spectroscopies. The effects of camphor and camphor analogues as substrates on the CO-binding kinetics for P-450cam were also studied under pressure. The positive activation volumes for CO binding were obtained for substrate-free and norcamphor- and adamantane-bound P-450, whereas other substrate analogue-bound P-450 complexes exhibited the negative activation volumes. All of the present high-pressure results are discussed in relation to (1) the dynamic aspects of the protein conformation, and (2) the specific participation of amino acid residues in the heme distal site in each elementary step of the ligand-binding reaction process.
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Conference papers on the topic "Cytochrome P-450 Genetic aspects"

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Dervisis, Nikolaos G., Maciej Parys, Annet Wenker, Patrick Venta, Barbara E. Kitchell, and Vilma Yuzbasiyan-Gurkan. "Abstract 2661: Evaluation of genetic variability of cytochrome P-450 members in the canine preclinical model." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2661.

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