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Relevant bibliographies by topics / Drug-receptor interaction

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Academic literature on the topic 'Drug-receptor interaction'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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Journal articles on the topic "Drug-receptor interaction"

1

Al-Qaaneh, Ayman. "Effect of antibiotics' electromagnetic spectrums on the bacterial growths: beyond drug-receptor interaction." Journal of Medical pharmaceutical and allied sciences 12, no. 6 (2023): 6241–46. http://dx.doi.org/10.55522/jmpas.v12i6.5904.

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Electromagnetic frequencies (EF) generated from different laboratory devices and appliances can interact with biological systems, including humans. Several studies have assessed the effect of electromagnetic frequencies on the growth of microorganisms, which revealed that EF could inhibit bacterial growth, decrease colony-forming units, or decrease viability depending on the field strength and frequency. Accordingly, in this study, we aimed to assess the effect of the antibiotics extracted electromagnetic spectrums on the growth of Staphylococcus aureus (S. aureus). Drugs digital electromagnet

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Kenakin, Kenakin T. "Pharmacologic Analysis of Drug Receptor Interaction." Therapeutic Drug Monitoring 10, no. 3 (1988): 365–66. http://dx.doi.org/10.1097/00007691-198803000-00029.

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Neidle, Stephen. "Molecular foundations of drug-receptor interaction." FEBS Letters 233, no. 1 (1988): 215. http://dx.doi.org/10.1016/0014-5793(88)81394-2.

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Netter, K. J. "Pharmacologic analysis of drug-receptor interaction." Toxicology 93, no. 2-3 (1994): 301–2. http://dx.doi.org/10.1016/0300-483x(94)90086-8.

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Gago, Federico. "Molecular foundations of drug-receptor interaction." Journal of Molecular Graphics 5, no. 4 (1987): 223. http://dx.doi.org/10.1016/0263-7855(87)80032-2.

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Leff, Paul. "Pharmacologie analysis of drug-receptor interaction." Trends in Pharmacological Sciences 8, no. 12 (1987): 516–17. http://dx.doi.org/10.1016/0165-6147(87)90052-6.

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Short, Angela L. "Pharmacologic analysis of drug-receptor interaction." Toxicology Letters 78, no. 1 (1995): 83. http://dx.doi.org/10.1016/0378-4274(95)90240-6.

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Kietzmann, M. "Pharmacological analysis of drug-receptor interaction." Toxicon 32, no. 3 (1994): 377. http://dx.doi.org/10.1016/0041-0101(94)90098-1.

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Muzammil, Mahreen, and Syed Saad Hussain. "Drug-Drug Interaction between Non-Steroidal Anti-Inflammatory and Angiotensin Receptor Blocker." National Journal of Health Sciences 6, no. 2 (2022): 88–89. http://dx.doi.org/10.21089/njhs.62.0088.

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Abstract: Objective: In pharmacotherapy, factors such as mode of administration, dose, and contraindications play a significant part in determining the optimal pharmacotherapeutic strategy. A drug’s ability to influence the safety or efficacy of another drug (drug-drug interaction) is another factor to consider when choosing the best pharmacotherapy [1]. When multiple medications are prescribed at the same time, they may interact [2]. Drug-drug interactions (DDIs) can have a variety of outcomes, and adverse DDIs might result in patient death or drug withdrawal. Drug interactions can alter the

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Gupta, Satya Prakash. "Roles of Fluorine in Drug Design and Drug Action." Letters in Drug Design & Discovery 16, no. 10 (2019): 1089–109. http://dx.doi.org/10.2174/1570180816666190130154726.

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The article discusses the basic properties of fluorine atom that have made it so useful in drug development. It presents several examples of therapeutically useful drugs acting against many life-threatening diseases along with the mechanism as to how fluorine influences the drug activity. It has been pointed out that fluorine, due to its ability to increase the lipophilicity of the molecule, greatly affects the hydrophobic interaction between the drug molecule and the receptor. Because of its small size, it hardly produces any steric effect, rather due to electronic properties enters into elec

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Dissertations / Theses on the topic "Drug-receptor interaction"

1

Lähdesmäki, Ilkka Johannes. "Flow injection methods for drug-receptor interaction studies, based on probing cell metabolism /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8590.

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Zheng, Yujuan. "The role of aryl hydrocarbon receptor (AHR) in drug-drug interaction and the expression of AHR in Pichia Pastoris." Scholarly Commons, 2019. https://scholarlycommons.pacific.edu/uop_etds/3580.

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The aryl hydrocarbon receptor is a ligand-activated transcription factor that is involved in many important functions in the body. To study the role and function of AHR, an abundant amount of in vitro expressed and purified protein is needed. A baculovirus insect expression system is commonly employed to express AHR, however, there are several drawbacks with this method, such as mutation potential and high cost. A better in overexpression system is needed and we hypothesize that Pichia pastoris, a yeast expression system, could stably express AHR and ARNT (aryl hydrocarbon receptor nuclear tra

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AIROLDI, CRISTINA. "Development of new potential antitumor drugs based on Ras protein inhibition." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2007. http://hdl.handle.net/10281/116562.

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Because of their role in oncogenesis, inhibition of Ras proteins, particularly of their tumorigenic variants, represents today one of the principal strategies finalized to the obtainment of new antitumoral therapies. Among the different possible approaches, one of the most innovative and less explored is represented by the inhibition of this protein activation, key event for the explication of their biological activity, but also for the Ras-induced tumoral cell transformation. Objective of this thesis has been the development of new small molecules able to inhibit, at least partially (total i

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Rimondini-Giorgini, Roberto. "Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3617-X/.

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Mitchell, T. J. "Theoretical investigations into some drug-receptor interactions." Thesis, University of Surrey, 1988. http://epubs.surrey.ac.uk/847811/.

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This study investigates some interactions of agonists with the adrenergic receptor using theoretical and computational chemistry methods. In Chapter 1, the effect of ring fluorination of noradrenaline on the specificity for the a and B receptor is considered. Using a simple receptor model, a conformational difference is found which can explain the experimental observations. In Chapter 2, various theoretical methods are applied to clonidine and a series of similar compounds. The results of these calculations are compared with the differing affinity and activity of these compounds with the adren

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Saunders, Martin. "Some theoretical aspects of drug receptor interactions." Thesis, University of Surrey, 1986. http://epubs.surrey.ac.uk/847992/.

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This thesis describes some attempts to model the effect of environment on a molecule, in particular, the effect of solvent and of the receptor site on the properties of a drug molecule. Chapter 1 describes the basic principles of drug activity, the forces responsible for binding of a drug to a receptor, and some of the consequences for drug design. Chapter 2 briefly reviews some of the quantitative structure-activity data available for angiotensin converting enzyme, and describes the design of a postulated active site by drawing an analogy with other zinc peptidases with known crystal structur

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Kruger, Karen. "A critical appraisal of intrinsic activity, efficacy and intrinsic efficacy with reference to the development and the current meaning / Karen Krüger." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1088.

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It has been observed that confusion exists in literature concerning the meaning and use of the term efficacy. Confusion is worsened by the use of the term as a general term describing agonist activity. The meaning of the terms intrinsic activity, efficacy and intrinsic efficacy as used in theoretical models of drug action was investigated. The classical occupation model, the two-state model, the ternary complex model (including conformational change and ideas surrounding G-proteins) and the operational model were studied in order to understand the historical and current usage of these terms. A

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Shearer, Jacqueline A. "The synthesis and biological evaluation of conformationally restricted analogues of octopamine." Thesis, University of Strathclyde, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278492.

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Plummer, Christopher John. "Studies of dopamine receptor and monoamine concentrations in the rat central nervous system." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.232929.

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Lewis, Richard Alan. "Molecular recognition and the development of an expert system for the design of novel drug molecules at specified binding sites." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253802.

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Books on the topic "Drug-receptor interaction"

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G, Cannon Joseph, ed. Advances in CNS Drug-receptor interactions: A research annual. JAIPress, 1991.

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Malmberg, Åsa. Dopamine D2 and D3 receptor-ligand interactions: Molecular pharmacology and medicinal chemistry. Acta Universitatis Upsaliensis, 1996.

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Kjell, Fuxe, and Agnati Luigi Francesca, eds. Receptor-receptor interactions: A new intramembrane integrative mechanism : proceedings of an international symposium held at the Wenner-Gren Center, Stockholm, October 9th-11th, 1986. Plenum Press, 1987.

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4

Robert, Rein, and Golombek Amram, eds. Computer-assisted modeling of receptor-ligand interactions: Theoretical aspects and applications to drug design : proceedings of the 1988 OHOLO Conference held in Eilat, Israel, April 24-28, 1988. Liss, 1989.

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5

Takao, Kumazawa, Kruger Lawrence, and Mizumura Kazue, eds. The polymodal receptor: A gateway to pathological pain. Elsevier, 1996.

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6

Molecular foundations of drug-receptor interaction. Cambridge University Press, 1987.

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7

Pharmacologic analysis of drug-receptor interaction. 2nd ed. Raven, 1993.

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Pharmacologic analysis of drug-receptor interaction. Raven Press, 1987.

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9

Pharmacologic analysis of drug-receptor interaction. 3rd ed. Lippincott-Raven Publishers, 1997.

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10

Serotonin-dopamine interaction: Experimental evidence and therapeutic relevance. Elsevier, 2008.

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Book chapters on the topic "Drug-receptor interaction"

1

Kenakin, Terry P. "Drug–Receptor Interaction." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_54.

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Kenakin, Terry P. "Drug–Receptor Interaction." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-21573-6_54-1.

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Zhao, Xinfeng, Qian Li, Jing Wang, Qi Liang, and Jia Quan. "Immobilized GPCRs in Drug-Receptor Interaction Analysis." In SpringerBriefs in Molecular Science. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0078-7_5.

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Gómez-Jeria, J. S. "Modeling the Drug-Receptor Interaction in Quantum Pharmacology." In Topics in Molecular Organization and Engineering. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-1173-4_10.

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Poduri, Ramarao, and Gowraganahalli Jagadeesh. "The Concept of Receptor and Molecule Interaction in Drug Discovery and Development." In Drug Discovery and Development. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-5534-3_3.

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Giacomelli, R., V. Filingeri, G. Famularo, et al. "Cyclosporin A — H2 Receptor Antagonists Drug Interaction in the Sprague-Dawley Rat." In Current Therapy in Nephrology. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0865-2_138.

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Ignar, D. M., and S. Rees. "The Study of Drug-Receptor Interaction Using Reporter Gene Systems in Mammalian Cells." In The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57081-0_15.

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Chandrasekaran, Balakumar, Haneen Al-Joubi, Sara Samarneh, et al. "Drug-Receptor Interactions." In Frontiers in Pharmacology of Neurotransmitters. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-3556-7_2.

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Hu, Amy, Lintao Jia, Jean-Christian Maillet, and Xia Zhang. "Tat-3L4F: A Novel Peptide for Treating Drug Addiction by Disrupting Interaction Between PTEN and 5-HT2C Receptor." In 5-HT2C Receptors in the Pathophysiology of CNS Disease. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-941-3_16.

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Soudijn, W., I. Van Wijngaarden, and A. P. Ijzerman. "Enantioselectivity in Drug-Receptor Interactions." In Stereochemical Aspects of Drug Action and Disposition. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-55842-9_7.

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Conference papers on the topic "Drug-receptor interaction"

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Salam, Ahmad, Vincent Hembrick, Jesse Jaynes, Timothy Turner, and Mohamed Abdalla. "Abstract 2170: Molecular modeling of novel peptide-receptor interaction for targeted drug delivery of prostate cancer." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2170.

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Jukić, Marko, and Urban Bren. "Identification of small molecule binding sites using CmDock." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.670j.

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Identification of binding sites for small molecules is critical in light of modern in silico and experimental methods for structure elucidation such as AlfaFold and CryoEM, respectively. The total number of entries in the PDB database is 208,702 through July 2023, and there are a large number of structural data without similar experimental entries and mechanistic or small molecule data. Herein, we report a simple, rapid, and efficient protocol for the identification of drug-like binding sites of small molecules using extended sampling with the self-developed molecular docking software CmDock.

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Liu, Yaling, Samar Shah, Walter Hu, and Jinming Gao. "Influence of Nanoparticle Design on Binding Efficiency." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13073.

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The shape of nanoparticles plays a vital role in their transportation and adhesion in to cardiovascular system. The specific adhesion of nanoparticles to vascular surface has numerous potential applications such targeted drug delivery, biomedical imaging, and cancer treatment. This paper proposes a novel modeling method that provides insights of the dynamic interaction between nanoparticle and vessel wall. The ligand-receptor adhesion kinetics along with brownian dynamics is coupled with hydrodynamics to study the dynamic delivery process. The binding probability of two different shaped nanopa

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Mathew, Shilu M., Fatiha Benslimane, Asmaa A. Althani, and Hadi M. Yassine. "Virtual Screening of Anti-Viral Drugs and Natural Compounds for Potential Inhibition of the Novel SARS-Cov-2 Spike Receptor-Binding Domain." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0281.

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Background: The spike (S) protein of SARS-CoV-2 harbors the receptor-binding domain (RBD) that mediates the virus's entry to host cells. The aim of this study was to identify novel inhibitors that target the RBD domain of S-protein through computational screening of chemical and natural compounds. Method: The S protein was modelled from the recently resolved and the previously described SARS-CoV protein structures. CLC Drug Discovery was used to computationally screen for potential inhibitory effects of currently prescribed drugs (n= 22) anti-viral natural drugs (n=100), natural compounds (n=

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SIMON, M. F., H. CHAP, and L. DOUSTE-BLAZY. "EFFECTS OF SIN 1 ON PLATELET ACTIVATION INDUCED BY THROMBIN IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643423.

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The mechanism of platelet activation is well known. The interaction of agonist such as thrombin, on specific membrane receptor induces phosphatidylinositol-specific phospholipase C activation, with a concomitant formation of two second messengers (from PIP2): inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 is able to induce a rapid discharge of Ca2+ from internal stores and Ca2+ influx through plasma membrane by unidentified Ca2+ channels linked to receptor activation. The increase of cytoplasmic free calcium concentration leads to the activation of the calcium calmodulin depe

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Apitz Castro, R., E. Ledezma, A. Jorquera, and M. K. Jain. "REVERSIBLE BLOCKADE OF PLATELET ACTIVATION DURING CARDIO-PUIMONAR BYPASS IN DOGS AFTER IV ADMINISTRATION OF AJOENE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644820.

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Surgery with extracorporeal circulation (ECC) is associated with platelet activation, which greatly contribute to prolonged postoperative bleeding and increased blood loss after surgery. Antiplatelet ccnpounds which induce rapid and reversible inhibition of platelet function, without affecting platelet adhesiveness would be potentially useful in the management of the platelet-dependent hemostatic disorder observed in ECC. Ajoene, an organosulfur originally obtained from garlic, inhibits platelet release and aggregation induced ex vivo by all know agonists. It does not affect shape change or ad

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Brace, L. D., J. Fareed, and D. Hoppensteadt. "EFFECTS OF THROMBOXANE PATHWAY ANTAGONISTS ON HEPARIN-INDUCED PLATELET AGGREGATION (H-IPA) AND TESTING FOR HEPARIN-INDUCED THROMBOCYTOPENIA (HIT)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643383.

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We have reported that heparin and heparin fractions can induce platelet aggregation (PA) in a substantial number of normal healthy drug-free donors. H-IPA was shown to depend upon the molecular weight and concentration of the heparin preparation used, but its mechanism remains unknown. Therefore, we performed experiments with antagonists of the thromboxane pathway to determine whether arachidonic acid metabolites contribute to H-IPA. When indomethacin or 13-azaprostanoic (a thromboxane receptor anatagonist) was added to the PRP of donors whose platelets had been shown to aggregate in response

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Khan, S. "Activation of pregnane X receptor (PXR) by herbal supplements and risk of Herb-Drug Interactions." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608590.

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Berndt, M. "STRUCTURE AND FUNCTION OF THE GLYCOPROTEIN Ib-IX COMPLEX." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643729.

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At high shear flow, the adhesion of platelets to the exposed vascular subendothelium requires von Willebrand factor (vWF) and is dependent upon a specific platelet membrane adhesion receptor, the human platelet membrane glycoprotein (GP) Ib-IX complex. Recent evidence suggests that vWFbinding to the GP Ib-IX complex plays an important role in other key aspects of hemostasis and thrombosis such as shear-induced platelet aggregation and the interaction of platelets with fibrin.Studies in our laboratory with a seriesof murine monoclonal antibodies directed against epitopes on GP lb, GP IX, or aga

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Warsito, Warsito, Masruri Masruri, Sinta Murlistyarini, Dwika Putri Pangesti, and Asyfariatus Zulfa Azhar. "Screening Multitarget Anticancer Compounds from Salicylic Acid Derivatives: (Without and with Amino Acid Linkage) by <i>In Silico</i> Docking." In International Conference on Chemistry and Material Sciences 2023 (IC2MS). Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-svkm5p.

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This research aims to design anticancer molecules using the hybridization concept based on molecular derivatives of salicylic acid. The investigation explores structures with and without linked amino acid alanine through an in-silico docking approach. The research conducts screenings of the designed salicylic acid derivative molecules against receptors, including MMP9, MMP2, CDK2, P53, BAK EGFR, and ADP Ribose Polymerase. The most promising docking results for multitarget cancer compounds were observed in salicylic acid derivatives with amino acid linkages, specifically salicylic acid-curcumin

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Reports on the topic "Drug-receptor interaction"

1

PENNSYLVANIA UNIV PHILADELPHIA. Discovery of Peptidomimetric Antagonists of Estrogen Receptor - Coactivator Interactions: A Novel Strategy to Combat Tamoxifen Drug Resistance. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada398889.

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