Relevant bibliographies by topics / Drugs Crystallization

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Academic literature on the topic 'Drugs Crystallization'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 February 2022

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Journal articles on the topic "Drugs Crystallization"

1

Kovačič, Borut, Franc Vrečer, and Odon Planinšek. "Spherical crystallization of drugs." Acta Pharmaceutica 62, no. 1 (2012): 1–14. http://dx.doi.org/10.2478/v10007-012-0010-5.

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Spherical crystallization of drugs Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo-co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, such as temperature, stirring rate, type and amount of solvents, or excipient selection, it is possible to control the formation of agglomerates and obtain spherical part
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Sibik, Juraj, Korbinian Löbmann, Thomas Rades, and J. Axel Zeitler. "Predicting Crystallization of Amorphous Drugs with Terahertz Spectroscopy." Molecular Pharmaceutics 12, no. 8 (2015): 3062–68. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00330.

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Konar, Atheni, Tandra Sarkar, Nirmal Chandra Sukul, and Anirban Sukul. "Drugs in ultra-high dilution induce changes in the enthalpy associated with loss of crystallization water in lactose." International Journal of High Dilution Research - ISSN 1982-6206 17, no. 1 (2021): 14. http://dx.doi.org/10.51910/ijhdr.v17i1.905.

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Drugs in ultra-high dilution (UHD) are used in homeopathy. Lactose is used as a binding medium for UHD drugs. FTIR and Raman spectroscopy revealed that although devoid of molecules of the starting substance, different UHD drugs exhibit different amounts of free water molecules and variation in hydrogen bond strength. The aim of the present study was to establish whether specific water structures in UHD could specifically modify the water structure in lactose, particularly the water of crystallization. 3 UHD’s (potencies), 30cH, 200cH and 1000cH, of 2 drugs, Natrum muriaticum and Sulphur were
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Wang, Andrew H. J., and Yi-Gui Gao. "Crystallization of oligonucleotides and their complexes with antitumor drugs." Methods 1, no. 1 (1990): 91–99. http://dx.doi.org/10.1016/s1046-2023(05)80151-3.

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Biscaia, Isabela Fanelli Barreto, Samantha Nascimento Gomes, Larissa Sakis Bernardi, and Paulo Renato Oliveira. "Obtaining Cocrystals by Reaction Crystallization Method: Pharmaceutical Applications." Pharmaceutics 13, no. 6 (2021): 898. http://dx.doi.org/10.3390/pharmaceutics13060898.

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Cocrystals have gained attention in the pharmaceutical industry due to their ability to improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble drugs. Conceptually, cocrystals are multicomponent solids that contain two or more neutral molecules in stoichiometric amounts within the same crystal lattice. There are several techniques for obtaining cocrystals described in the literature; however, the focus of this article is the Reaction Crystallization Method (RCM). This method is based on the generation of a supersaturated solution with respect to the cocr
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Patel, M. Siddik N., Mohd Hasib Ahmed, Mohammad Saqib, and Siraj N. Shaikh. "Chemical Modification: A unique solutions to Solubility problem." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 542–46. http://dx.doi.org/10.22270/jddt.v9i2.2432.

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Almost 40% of the new chemical entities at present self find out poorly water soluble drugs. Badly water soluble drugs have solubility and dissolution related bioavailability problems. Solubility is one of the most important parameter to give desired concentration of drug in systemic circulation to get its pharmacological response. Orally administered drugs obtained completely absorb only when they show fair solubility in gastric medium and such drugs shows good bioavailability. The solubility and dissolution properties of drugs perform an valuable role in the process of formulation developmen
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Alhalaweh, Amjad, Ahmad Alzghoul, and Christel A. S. Bergström. "Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions." Journal of Pharmaceutical Sciences 108, no. 1 (2019): 252–59. http://dx.doi.org/10.1016/j.xphs.2018.11.006.

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Park, Su‐Jin, and Sang‐Do Yeo. "Antisolvent Crystallization of Sulfa Drugs and the Effect of Process Parameters." Separation Science and Technology 42, no. 12 (2007): 2645–60. http://dx.doi.org/10.1080/01496390701512976.

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Loth, H., and E. Hemgesberg. "Properties and dissolution of drugs micronized by crystallization from supercritical gases." International Journal of Pharmaceutics 32, no. 2-3 (1986): 265–67. http://dx.doi.org/10.1016/0378-5173(86)90188-2.

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Yao, Xin, Amy Lan Neusaenger, and Lian Yu. "Amorphous Drug-Polymer Salts." Pharmaceutics 13, no. 8 (2021): 1271. http://dx.doi.org/10.3390/pharmaceutics13081271.

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Amorphous formulations provide a general approach to improving the solubility and bioavailability of drugs. Amorphous medicines for global health should resist crystallization under the stressful tropical conditions (high temperature and humidity) and often require high drug loading. We discuss the recent progress in employing drug–polymer salts to meet these goals. Through local salt formation, an ultra-thin polyelectrolyte coating can form on the surface of amorphous drugs, immobilizing interfacial molecules and inhibiting fast crystal growth at the surface. The coated particles show improve
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Dissertations / Theses on the topic "Drugs Crystallization"

1

Keats, Clare J. "Crystallization and polymorphism of putative drugs." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404167.

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Ruiz, Guadalupe Natalia. "Relaxation dynamics and crystallization kinetics of glass-forming drugs." Doctoral thesis, Universitat Politècnica de Catalunya, 2018. http://hdl.handle.net/10803/663205.

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Glassy phases play an important role in our daily life and in many industries such as the food, pharmaceutical, and construction and are responsible for certain vital mechanisms in living species. Whereas crystals are solid phases that show periodicity of the constituent atoms or molecules, glasses are disordered solids that lack long-range positional order but behave mechanically like solids. Chapter 1 of the current thesis presents an introduction to the characteristics and dynamics of glassy phases. How they are derived from the liquid phase, and how they transform into the crystalline soli
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Zhou, Jun Hu Zhibing. "Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/permalink/meta-dc-11001.

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OLIVEIRA, MARIA J. A. de. "Sintese, caracterizacao e citotoxicidade de hidrogeis polimericos para imobilizacao de farmaco empregado no tratamento de Leihmaniose." reponame:Repositório Institucional do IPEN, 2008. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11749.

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Made available in DSpace on 2014-10-09T12:55:24Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:04:56Z (GMT). No. of bitstreams: 0<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Dissertação (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP<br>FAPESP:06/53634-3
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Strachan, Clare, and n/a. "Spectroscopic investigation and quantitation of polymorphism and crystallinity of pharmaceutical compounds." University of Otago. School of Pharmacy, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070427.141108.

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Spectroscopy is increasingly used to investigate and monitor the solid state forms of pharmaceutical materials and products. Spectroscopy�s speed, nondestructive sampling, compatibility with fibre optics and safety also make it attractive for in-line monitoring. In this thesis, the spectroscopic techniques Fourier transform Raman spectroscopy, terahertz pulsed spectroscopy and second harmonic generation were used to characterise and quantify polymorphism and crystallinity of pharmaceutical compounds. Where possible, the multivariate analysis technique partial least squares was used for quant
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Nyamayaro, Kudzanai. "Dissolution control of highly soluble active pharmaceutical ingredients via cocrystallisation." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2673.

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Thesis (MTech (Chemistry))--Cape Peninsula University of Technology, 2017.<br>Crystal engineering involves the manipulation of intermolecular interactions to design functionalised crystalline materials and has proved to be an effective tool for the modification of physicochemical properties of active pharmaceutical ingredients (APIs). In the first section of this study, the aim was to systematically influence the rate of dissolution of a highly soluble active pharmaceutical ingredient using crystal engineering principles. Salicylic acid (SA) was employed as a model API to form multicompon
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Ozaki, Shunsuke. "Physicochemical Understanding of Solubility and Supersaturation for the Enhancement of the Oral Absorbability of Poorly Soluble Drugs." Kyoto University, 2015. http://hdl.handle.net/2433/199344.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19020号<br>農博第2098号<br>新制||農||1030(附属図書館)<br>学位論文||H27||N4902(農学部図書室)<br>31971<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授 加納 健司, 教授 宮川 恒, 教授 三上 文三<br>学位規則第4条第1項該当
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Zhou, Jun. "Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc11001/.

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Tissue response to PNIPAM and HPC nanoparticles has been studied by implantation method. The results suggest that both PNIAPM and HPC nanoparticles possess good biocompatibility and they may serve as a good carrier for the applications of controlled delivery. Rheological properties of dispersions of IPN microgels composed of PNIPAM and PAAc have been studied. It is found that the IPN microgel dispersion can undergo a sol-gel transition at temperature above 33°C. In vivo drug release experiments suggest that the gelation procedure creates a diffusion barrier and thus leads to slow release. An e
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Thakare, Kalpana. "THE EVALUATION OF LARCH ARABINOGALACTAN AS A NEW CARRIER IN THE FORMULATION OF SOLID DISPERSIONS OF POORLY WATER- SOLUBLE DRUGS." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/232942.

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Pharmaceutical Sciences<br>Ph.D.<br>Advanced drug discovery techniques have produced more lipophilic compounds. Formation of an amorphous solid dispersion of such poorly water-soluble drugs improves their solubility and dissolution. This results in greater in vivo bioavailability. Thus, it is one of the recent trends in the development of oral dosage forms. In solid dispersions, the carrier is crucial for ensuring the functionality and stability of these systems. Larch arabinogalactan FiberAid grade (AGF) is generally recognized as safe (GRAS) designated, amorphous polymer. The objective of th
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Setiawan, Nico. "UNDERSTANDING THE THERMODYNAMICS AND ORAL ABSORPTION POTENTIAL OF PHARMACEUTICAL AMORPHOUS SOLID DISPERSIONS." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacy_etds/85.

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Supersaturating drug delivery systems, such as amorphous solid dispersions (ASDs), have been used extensively to elevate the apparent solubility and oral bioavailability of poorly water-soluble drugs. However, despite the numerous examples of success in increasing solubility and oral bioavailability using ASDs, physical stability challenges remain as formulators seek to employ high drug loading for cost reduction and improved patient compliance. Therefore, stability in both the solid and solution state must be considered for ASDs to be successful. In the solid state, the drug must remain amorp
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Books on the topic "Drugs Crystallization"

1

Membrane-active peptides: Methods and results on structure and function. International University Line, 2009.

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M, Bergfors Terese, ed. Protein crystallization. International University Line, 2008.

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Polymorphism of Pharmaceutical Solids, Second Edition (Drugs and the Pharmaceutical Sciences). 2nd ed. Informa Healthcare, 2009.

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(Editor), Robert E. Babine, Sherin S. Abdel-Meguid (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), and Gerd Folkers (Series Editor), eds. Protein Crystallography in Drug Discovery (Methods and Principles in Medicinal Chemistry). Wiley-VCH, 2004.

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E, Babine R., and Abdel-Meguid S. S, eds. Protein crystallography in drug discovery. Wiley-VCH, 2004.

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Book chapters on the topic "Drugs Crystallization"

1

Skarina, Tatiana, Xiaohui Xu, Elena Evdokimova, and Alexei Savchenko. "High-Throughput Crystallization Screening." In Structural Genomics and Drug Discovery. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0354-2_12.

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Hoffman, Isaac D. "Protein Crystallization for Structure-Based Drug Design." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-520-6_4.

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Yamada, Mitsugu, Kiyohito Kihira, Momi Iwata, et al. "Protein Crystallization in Space and Its Contribution to Drug Development." In Handbook of Space Pharmaceuticals. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-50909-9_40-1.

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Langendorf, Christopher G., Jonathan S. Oakhill, and Bruce E. Kemp. "Visualizing AMPK Drug Binding Sites Through Crystallization of Full-Length Phosphorylated α2β1γ1 Heterotrimer." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7598-3_2.

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Javadzadeh, Yousef, Zhila Vazifehasl, Solmaz Maleki Dizaj, and Masumeh Mokhtarpour. "Spherical Crystallization of Drugs." In Advanced Topics in Crystallization. InTech, 2015. http://dx.doi.org/10.5772/59627.

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Patra, Chinam Niranjan, Suryakanta Swain, Kahnu Charan Panigrahi, and Muddana Eswara Bhanoji Rao. "Spherical crystallization techniques." In Pharmaceutical drug delivery systems and vehicles. WPI Publishing, 2018. http://dx.doi.org/10.1201/9781315364353-4.

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MacWilliams, Maria, and Mark Chiu. "Toward Crystallization of G Protein-Coupled Receptors." In Drug Discovery Series. CRC Press, 2005. http://dx.doi.org/10.1201/9781420028218.ch12.

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"Separation and resolution of enantiomers and their dissociable diastereomers through direct crystallization." In Drug Stereochemistry. CRC Press, 2012. http://dx.doi.org/10.3109/9781420092394-7.

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"Toward Crystallization of G Protein-Coupled Receptors." In G Protein-Coupled Receptors in Drug Discovery. CRC Press, 2005. http://dx.doi.org/10.1201/9781420028218-17.

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Prasad, Mailavaram Raghu, Pran Kishore Deb, Balakumar Chandrasekaran, Rahul Maheshwari, and Rakesh K. Tekade. "Basics of Crystallization Process Applied in Drug Exploration." In Dosage Form Design Parameters. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-814421-3.00003-8.

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Conference papers on the topic "Drugs Crystallization"

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Wijanarko, Anondho, Maria Prisca Meivita, Heri Hermansyah, Muhamad Sahlan, and Richard Lakerveld. "Batch crystallization of rifapentine for inhalable tuberculosis medication." In 2ND BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2017. Author(s), 2018. http://dx.doi.org/10.1063/1.5023970.

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Schoenitz, Martin, Annika Hohlen, Wolfgang Augustin, and Stephan Scholl. "In-Process Cleaning of a Micro Heat Exchanger With Ultrasound During the Continuous Crystallization of Solid Lipid Nanoparticles." In ASME 2014 12th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2014 4th Joint US-European Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icnmm2014-21821.

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Process intensification by the application of microscale process engineering in reaction and heat transfer processes provides the opportunity of moving from batch to continuous manufacturing, mainly due to enhanced heat and mass transfer. These effects are primarily caused by the very high surface to volume ratio in microstructured devices. Further advantages, particularly suitable for sensitive products, are the low shear stress in the typically occurring laminar regime and the short residence time. The crystallization of drug carrying lipid nanoparticles (LNP) is a typical batch process for
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Khan, Saif A. "MOLECULAR CRYSTALLIZATION IN MICROFLUIDIC DROPLET ENSEMBLES – TOWARDS DESIGNER PHARMACEUTICAL DRUG PRODUCTS." In The 7th International Multidisciplinary Conference on Optofluidics 2017. MDPI, 2017. http://dx.doi.org/10.3390/optofluidics2017-04504.

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Russo, Mark F., Stephen Michalczyk, Matthew H. Cahn, and Herbert Klei. "Petri net modeling and automated system control of protein crystallization experimentation in drug discovery." In 2008 IEEE International Conference on Automation Science and Engineering (CASE 2008). IEEE, 2008. http://dx.doi.org/10.1109/coase.2008.4626416.

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Reports on the topic "Drugs Crystallization"

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DeLucas, Lawrence J. Crystallization, X-Ray Structure Determination and Structure-Based Drug Design for Targeted Malarial Enzymes. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada360337.

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