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Journal articles on the topic 'Drugs Crystallization'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Kovačič, Borut, Franc Vrečer, and Odon Planinšek. "Spherical crystallization of drugs." Acta Pharmaceutica 62, no. 1 (2012): 1–14. http://dx.doi.org/10.2478/v10007-012-0010-5.

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Spherical crystallization of drugs Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo-co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, such as temperature, stirring rate, type and amount of solvents, or excipient selection, it is possible to control the formation of agglomerates and obtain spherical part

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2

Sibik, Juraj, Korbinian Löbmann, Thomas Rades, and J. Axel Zeitler. "Predicting Crystallization of Amorphous Drugs with Terahertz Spectroscopy." Molecular Pharmaceutics 12, no. 8 (2015): 3062–68. http://dx.doi.org/10.1021/acs.molpharmaceut.5b00330.

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3

Konar, Atheni, Tandra Sarkar, Nirmal Chandra Sukul, and Anirban Sukul. "Drugs in ultra-high dilution induce changes in the enthalpy associated with loss of crystallization water in lactose." International Journal of High Dilution Research - ISSN 1982-6206 17, no. 1 (2021): 14. http://dx.doi.org/10.51910/ijhdr.v17i1.905.

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Drugs in ultra-high dilution (UHD) are used in homeopathy. Lactose is used as a binding medium for UHD drugs. FTIR and Raman spectroscopy revealed that although devoid of molecules of the starting substance, different UHD drugs exhibit different amounts of free water molecules and variation in hydrogen bond strength. The aim of the present study was to establish whether specific water structures in UHD could specifically modify the water structure in lactose, particularly the water of crystallization. 3 UHDâ€™s (potencies), 30cH, 200cH and 1000cH, of 2 drugs, Natrum muriaticum and Sulphur were

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4

Wang, Andrew H. J., and Yi-Gui Gao. "Crystallization of oligonucleotides and their complexes with antitumor drugs." Methods 1, no. 1 (1990): 91–99. http://dx.doi.org/10.1016/s1046-2023(05)80151-3.

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5

Biscaia, Isabela Fanelli Barreto, Samantha Nascimento Gomes, Larissa Sakis Bernardi, and Paulo Renato Oliveira. "Obtaining Cocrystals by Reaction Crystallization Method: Pharmaceutical Applications." Pharmaceutics 13, no. 6 (2021): 898. http://dx.doi.org/10.3390/pharmaceutics13060898.

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Cocrystals have gained attention in the pharmaceutical industry due to their ability to improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble drugs. Conceptually, cocrystals are multicomponent solids that contain two or more neutral molecules in stoichiometric amounts within the same crystal lattice. There are several techniques for obtaining cocrystals described in the literature; however, the focus of this article is the Reaction Crystallization Method (RCM). This method is based on the generation of a supersaturated solution with respect to the cocr

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6

Patel, M. Siddik N., Mohd Hasib Ahmed, Mohammad Saqib, and Siraj N. Shaikh. "Chemical Modification: A unique solutions to Solubility problem." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 542–46. http://dx.doi.org/10.22270/jddt.v9i2.2432.

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Almost 40% of the new chemical entities at present self find out poorly water soluble drugs. Badly water soluble drugs have solubility and dissolution related bioavailability problems. Solubility is one of the most important parameter to give desired concentration of drug in systemic circulation to get its pharmacological response. Orally administered drugs obtained completely absorb only when they show fair solubility in gastric medium and such drugs shows good bioavailability. The solubility and dissolution properties of drugs perform an valuable role in the process of formulation developmen

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7

Alhalaweh, Amjad, Ahmad Alzghoul, and Christel A. S. Bergström. "Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions." Journal of Pharmaceutical Sciences 108, no. 1 (2019): 252–59. http://dx.doi.org/10.1016/j.xphs.2018.11.006.

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8

Park, Su‐Jin, and Sang‐Do Yeo. "Antisolvent Crystallization of Sulfa Drugs and the Effect of Process Parameters." Separation Science and Technology 42, no. 12 (2007): 2645–60. http://dx.doi.org/10.1080/01496390701512976.

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9

Loth, H., and E. Hemgesberg. "Properties and dissolution of drugs micronized by crystallization from supercritical gases." International Journal of Pharmaceutics 32, no. 2-3 (1986): 265–67. http://dx.doi.org/10.1016/0378-5173(86)90188-2.

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10

Yao, Xin, Amy Lan Neusaenger, and Lian Yu. "Amorphous Drug-Polymer Salts." Pharmaceutics 13, no. 8 (2021): 1271. http://dx.doi.org/10.3390/pharmaceutics13081271.

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Amorphous formulations provide a general approach to improving the solubility and bioavailability of drugs. Amorphous medicines for global health should resist crystallization under the stressful tropical conditions (high temperature and humidity) and often require high drug loading. We discuss the recent progress in employing drug–polymer salts to meet these goals. Through local salt formation, an ultra-thin polyelectrolyte coating can form on the surface of amorphous drugs, immobilizing interfacial molecules and inhibiting fast crystal growth at the surface. The coated particles show improve

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11

Surov, Artem O., Alexander P. Voronin, Ksenia V. Drozd, Andrei V. Churakov, Pascal Roussel, and German L. Perlovich. "Diversity of crystal structures and physicochemical properties of ciprofloxacin and norfloxacin salts with fumaric acid." CrystEngComm 20, no. 6 (2018): 755–67. http://dx.doi.org/10.1039/c7ce02033c.

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The crystallization of norfloxacin and ciprofloxacin – antibacterial fluoroquinolone compounds – with fumaric acid resulted in the isolation of six distinct solid forms of the drugs with different stoichiometries and hydration levels.

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12

Kawakami, Kohsaku. "Crystallization Tendency of Pharmaceutical Glasses: Relevance to Compound Properties, Impact of Formulation Process, and Implications for Design of Amorphous Solid Dispersions." Pharmaceutics 11, no. 5 (2019): 202. http://dx.doi.org/10.3390/pharmaceutics11050202.

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Amorphous solid dispersions (ASDs) are important formulation strategies for improving the dissolution process and oral bioavailability of poorly soluble drugs. Physical stability of a candidate drug must be clearly understood to design ASDs with superior properties. The crystallization tendency of small organics is frequently estimated by applying rapid cooling or a cooling/reheating cycle to their melt using differential scanning calorimetry. The crystallization tendency determined in this way does not directly correlate with the physical stability during isothermal storage, which is of great

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13

Wei, An Fang, Juan Wang, Xue Qian Wang, Qu Fu Wei, and Da Yin Hou. "Biodegradable Electrospun Fibers Containing the Compound Antihypertensive Drugs." Advanced Materials Research 332-334 (September 2011): 1218–22. http://dx.doi.org/10.4028/www.scientific.net/amr.332-334.1218.

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In this study, the biodegradable composite fiber contained different ratios of the compound antihypertensive drugs were electrospun.The morphology, chemical components, heat stability of the composite fibers were investigated.The results showed the diameters of the composite fibers decreased and their distributions tended to be much evener with the increase of the compound antihypertensive drugs content. Fourier Transform Infrared (FT-IR) showed the chemical components of the compound antihypertensive drugs had not changed when it was electrospun into the composite fibers. DSC results showed t

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14

Reddy, C. Malla. "Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes." IUCrJ 6, no. 4 (2019): 505–6. http://dx.doi.org/10.1107/s205225251900890x.

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15

Delpe Acharige, Anjana M. D. S., Mark P. C. Brennan, Kate Lauder, Fiona McMahon, Adesola O. Odebunmi та Marcus C. Durrant. "Computational insights into the inhibition of β-haematin crystallization by antimalarial drugs". Dalton Transactions 47, № 43 (2018): 15364–81. http://dx.doi.org/10.1039/c8dt03369b.

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16

Chaudhari, Shilpa, Sarika Ankushrao Nikam, Neetu Khatri, and Shubham Wakde. "CO-CRYSTALS: A REVIEW." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 350–58. http://dx.doi.org/10.22270/jddt.v8i6-s.2194.

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In development of new product major constraints are poor aqueous solubility and low oral bioavailability. Crystallization is one the approach has been used for enhancement of solubility of poorly aqueous soluble drugs also helps to improve physicochemical properties such as melting point, tabletability, solubility, stability, bioavailability and permeability with preserving the pharmacological properties of the active pharmaceutical ingredient. Different methods have been used for the synthesis of cocrystal such as grinding, slurry, antisolvent, hot melt extrusion, sonocrystallization, supercr

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17

Pisciotta, John M., Isabelle Coppens, Abhai K. Tripathi, et al. "The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization." Biochemical Journal 402, no. 1 (2007): 197–204. http://dx.doi.org/10.1042/bj20060986.

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The intraerythrocytic malaria parasite constructs an intracellular haem crystal, called haemozoin, within an acidic digestive vacuole where haemoglobin is degraded. Haem crystallization is the target of the widely used antimalarial quinoline drugs. The intracellular mechanism of molecular initiation of haem crystallization, whether by proteins, polar membrane lipids or by neutral lipids, has not been fully substantiated. In the present study, we show neutral lipid predominant nanospheres, which envelop haemozoin inside Plasmodium falciparum digestive vacuoles. Subcellular fractionation of para

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18

Tran, Phuong H. L., Wei Duan, Beom-Jin Lee, and Thao T. D. Tran. "Modulation of Drug Crystallization and Molecular Interactions by Additives in Solid Dispersions for Improving Drug Bioavailability." Current Pharmaceutical Design 25, no. 18 (2019): 2099–107. http://dx.doi.org/10.2174/1381612825666190618102717.

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Background:: An increase in poorly water-soluble drugs makes the design of drug delivery systems challenging. Methods:: Currently, a number of prospective solid dispersions have been investigated with potential applications for delivering a variety of poorly water-soluble drugs. A number of traditional solid dispersions and modifiedsolid dispersions offer attractive advantages in the fabrication, design and development of those drugs for effective therapeutics. Results:: Although traditional solid dispersions can produce a higher release rate, resulting in higher bioavailability compared to co

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19

Ketchum, Megan A., Andrea M. Lee, Peter G. Vekilov, and Jeffrey D. Rimer. "Biomimetic Assay for Hematin Crystallization Inhibitors: A New Platform To Screen Antimalarial Drugs." Crystal Growth & Design 17, no. 1 (2016): 197–206. http://dx.doi.org/10.1021/acs.cgd.6b01424.

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20

Rasenack, Norbert, Hartwig Steckel, and Bernd W. Müller. "Micronization of Anti-Inflammatory Drugs for Pulmonary Delivery by a Controlled Crystallization Process." Journal of Pharmaceutical Sciences 92, no. 1 (2003): 35–44. http://dx.doi.org/10.1002/jps.10274.

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21

Tolochko, N. K., I. A. Yadroitsev, A. Z. Myal’dun, V. A. Kuznetsov, T. M. Okhrimenko, and P. York. "Optimization of the local crystallization processes of preparing chiral drugs in periodic crystallizers." Crystallography Reports 48, no. 6 (2003): 1059–63. http://dx.doi.org/10.1134/1.1627448.

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22

Xu, Yueming, Yuxia Wang, Yang Wang, et al. "Mutagenesis facilitated crystallization of GLP-1R." IUCrJ 6, no. 6 (2019): 996–1006. http://dx.doi.org/10.1107/s2052252519013496.

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The class B family of G-protein-coupled receptors (GPCRs) has long been a paradigm for peptide hormone recognition and signal transduction. One class B GPCR, the glucagon-like peptide-1 receptor (GLP-1R), has been considered as an anti-diabetes drug target and there are several peptidic drugs available for the treatment of this overwhelming disease. The previously determined structures of inactive GLP-1R in complex with two negative allosteric modulators include ten thermal-stabilizing mutations that were selected from a total of 98 designed mutations. Here we systematically summarize all 98 m

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23

Sun, Mengmeng, Du Shichao, Weiwei Tang, Lina Jia, and Junbo Gong. "Design of Spherical Crystallization for Drugs Based on Thermal-Induced Liquid–Liquid Phase Separation: Case Studies of Water-Insoluble Drugs." Industrial & Engineering Chemistry Research 58, no. 44 (2019): 20401–11. http://dx.doi.org/10.1021/acs.iecr.9b03795.

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24

Chen, Kui, Baohong Hou, Hao Wu, et al. "Hollow and Solid Spherical Azithromycin Particles Prepared by Different Spherical Crystallization Technologies for Direct Tableting." Processes 7, no. 5 (2019): 276. http://dx.doi.org/10.3390/pr7050276.

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Many drugs have a propensity for agglomeration, resulting in poor flowability. Spherical crystallization can be used to improve product properties including flowability and particle size. In this work, two methods were developed and utilized to successfully make two kinds of azithromycin spherical particles, namely solid and hollow spheres. The resultant product exhibited regular spherical shape, large particle size, narrow particle size distribution and excellent flowability. The formation mechanism of these different spherical crystals was investigated with the help of a particle vision micr

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25

Olafson, Katy N., Megan A. Ketchum, Jeffrey D. Rimer, and Peter G. Vekilov. "Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine." Proceedings of the National Academy of Sciences 112, no. 16 (2015): 4946–51. http://dx.doi.org/10.1073/pnas.1501023112.

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Hematin crystallization is the primary mechanism of heme detoxification in malaria parasites and the target of the quinoline class of antimalarials. Despite numerous studies of malaria pathophysiology, fundamental questions regarding hematin growth and inhibition remain. Among them are the identity of the crystallization medium in vivo, aqueous or organic; the mechanism of crystallization, classical or nonclassical; and whether quinoline antimalarials inhibit crystallization by sequestering hematin in the solution, or by blocking surface sites crucial for growth. Here we use time-resolved in s

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26

Lu, Jennifer, James D. Ormes, Michael Lowinger, et al. "Compositional effect of complex biorelevant media on the crystallization kinetics of an active pharmaceutical ingredient." CrystEngComm 19, no. 32 (2017): 4797–806. http://dx.doi.org/10.1039/c7ce01128h.

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27

Kapishnikov, Sergey, Trine Staalsø, Yang Yang, et al. "Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo." Proceedings of the National Academy of Sciences 116, no. 46 (2019): 22946–52. http://dx.doi.org/10.1073/pnas.1910123116.

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The most widely used antimalarial drugs belong to the quinoline family. Their mode of action has not been characterized at the molecular level in vivo. We report the in vivo mode of action of a bromo analog of the drug chloroquine in rapidly frozen Plasmodium falciparum-infected red blood cells. The Plasmodium parasite digests hemoglobin, liberating the heme as a byproduct, toxic to the parasite. It is detoxified by crystallization into inert hemozoin within the parasitic digestive vacuole. By mapping such infected red blood cells with nondestructive X-ray microscopy, we observe that bromoquin

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28

SANO, Akimitsu, Takeo KURIKI, Yoshiaki KAWASHIMA, Hirofumi TAKEUCHI, Tomoaki HINO, and Toshiyuki NIWA. "Particle Design for Antidiabetic Drugs by the Spherical Crystallization Technique. IV. Assessment of Compressibility of Agglomerated Tolbutamide Crystals Prepared by Crystallization Technique." CHEMICAL & PHARMACEUTICAL BULLETIN 40, no. 6 (1992): 1573–81. http://dx.doi.org/10.1248/cpb.40.1573.

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29

Ulker, Zeynep, and Can Erkey. "An advantageous technique to load drugs into aerogels: Gas antisolvent crystallization inside the pores." Journal of Supercritical Fluids 120 (February 2017): 310–19. http://dx.doi.org/10.1016/j.supflu.2016.05.033.

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30

Buendía, Julia, Emilio Matesanz, David K. Smith, and Luis Sánchez. "Multi-component supramolecular gels for the controlled crystallization of drugs: synergistic and antagonistic effects." CrystEngComm 17, no. 42 (2015): 8146–52. http://dx.doi.org/10.1039/c5ce01293g.

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31

Martusevich, Andrew Kimovich. "use of methods of the biocrystallomics in personification of the treatment with high diluted drugs." International Journal of High Dilution Research - ISSN 1982-6206 17, no. 2 (2021): 33. http://dx.doi.org/10.51910/ijhdr.v17i2.938.

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Background: One of most important trends in modern medicine is its transformation to personalized diagnostics and treatment. This tendency fully applies to homeopathy, especially considering that this discipline is based on the principles of individual approach to the patient. At the same time, the methods of individualization of treatment in homeopathy are relatively few.  Aims: Develop of methodology and methods of application biocrystalloscopic tests to personalize the homeopathic treatment. The proposed technology became previously proposed for ozone therapy practice as biocrystallom

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32

Bacchi, Alessia, Davide Capucci, and Paolo Pelagatti. "Trapping liquid drugs inside crystals." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C984. http://dx.doi.org/10.1107/s2053273314090159.

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The objective of this work is to embed liquid or volatile pharmaceuticals inside crystalline materials, in order to tune their delivery properties in medicine or agrochemistry, and to explore new regulatory and intellectual properties issues. Liquid or volatile formulations of active pharmaceutical ingredients (APIs) are intrinsically less stable and durable than solid forms; in fact most drugs are formulated as solid dosage because they tend to be stable, reproducible, and amenable to purification. Most drugs and agrochemicals are manufactured and distributed as crystalline materials, and the

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33

Edueng, Bergström, Gråsjö, and Mahlin. "Long-Term Physical (In)Stability of Spray-Dried Amorphous Drugs: Relationship with Glass-Forming Ability and Physicochemical Properties." Pharmaceutics 11, no. 9 (2019): 425. http://dx.doi.org/10.3390/pharmaceutics11090425.

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This study shows the importance of the chosen method for assessing the glass-forming ability (GFA) and glass stability (GS) of a drug compound. Traditionally, GFA and GS are established using in situ melt-quenching in a differential scanning calorimeter. In this study, we included 26 structurally diverse glass-forming drugs (i) to compare the GFA class when the model drugs were produced by spray-drying with that when melt-quenching was used, (ii) to investigate the long-term physical stability of the resulting amorphous solids, and (iii) to investigate the relationship between physicochemical

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34

Reutzel-Edens, Susan M., and Rajni M. Bhardwaj. "Crystal forms in pharmaceutical applications: olanzapine, a gift to crystal chemistry that keeps on giving." IUCrJ 7, no. 6 (2020): 955–64. http://dx.doi.org/10.1107/s2052252520012683.

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This contribution reviews the efforts of many scientists around the world to discover and structurally characterize olanzapine crystal forms, clearing up inconsistencies in the scientific and patent literature and highlighting the challenges in identifying new forms amidst 60+ known polymorphs and solvates. Owing to its remarkable solid-state chemistry, olanzapine has emerged over the last three decades as a popular tool compound for developing new experimental and computational methods for enhanced molecular level understanding of solid-state structure, form diversity and crystallization outc

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35

Nugrahani, Ilma, and Rismaya Desti Parwati. "Challenges and Progress in Nonsteroidal Anti-Inflammatory Drugs Co-Crystal Development." Molecules 26, no. 14 (2021): 4185. http://dx.doi.org/10.3390/molecules26144185.

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Co-crystal innovation is an opportunity in drug development for both scientists and industry. In line with the “green pharmacy” concept for obtaining safer methods and advanced pharmaceutical products, co-crystallization is one of the most promising approaches to find novel patent drugs, including non-steroidal anti-inflammatory drugs (NSAID). This kind of multi-component system improves previously poor physicochemical and mechanical properties through non-covalent interactions. Practically, there are many challenges to find commercially viable co-crystal drugs. The difficulty in selecting co-

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36

Wood, Matthew R., Sandra Mikhael, Ivan Bernal, and Roger A. Lalancette. "Erdmann’s Anion—An Inexpensive and Useful Species for the Crystallization of Illicit Drugs after Street Confiscations." Chemistry 3, no. 2 (2021): 598–611. http://dx.doi.org/10.3390/chemistry3020042.

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Erdmann’s anion [1,6-diammino tetranitrocobaltate(III)] is useful in the isolation and crystallization of recently confiscated street drugs needing to be identified and catalogued. The protonated form of such drugs forms excellent crystals with that anion; moreover, Erdmann’s salts are considerably less expensive than the classically used AuCl4− anion to isolate them, while preparation of high-quality crystals is equally easy in both cases. We describe the preparation and structures of the K+CoH6N6O8− and NH4+CoH6N7O8−, salts of Erdmann’s. In addition, herein are described the preparations of

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37

Olafson, Katy N., Tam Q. Nguyen, Jeffrey D. Rimer, and Peter G. Vekilov. "Antimalarials inhibit hematin crystallization by unique drug–surface site interactions." Proceedings of the National Academy of Sciences 114, no. 29 (2017): 7531–36. http://dx.doi.org/10.1073/pnas.1700125114.

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In malaria pathophysiology, divergent hypotheses on the inhibition of hematin crystallization posit that drugs act either by the sequestration of soluble hematin or their interaction with crystal surfaces. We use physiologically relevant, time-resolved in situ surface observations and show that quinoline antimalarials inhibit β-hematin crystal surfaces by three distinct modes of action: step pinning, kink blocking, and step bunch induction. Detailed experimental evidence of kink blocking validates classical theory and demonstrates that this mechanism is not the most effective inhibition pathwa

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38

Zhou, Qi, Zhongchuan Tan, Desen Yang, et al. "Improving the Solubility of Aripiprazole by Multicomponent Crystallization." Crystals 11, no. 4 (2021): 343. http://dx.doi.org/10.3390/cryst11040343.

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Aripiprazole (ARI) is a third-generation antipsychotic with few side effects but a poor solubility. Salt formation, as one common form of multicomponent crystals, is an effective strategy to improve pharmacokinetic profiles. In this work, a new ARI salt with adipic acid (ADI) and its acetone hemisolvate were obtained successfully, along with a known ARI salt with salicylic acid (SAL). Their comprehensive characterizations were conducted using X-ray diffraction and differential scanning calorimetry. The crystal structures of the ARI-ADI salt acetone hemisolvate and ARI-SAL salt were elucidated

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39

Fili, S., A. Valmas, M. Norrman, et al. "Human insulin polymorphism upon ligand binding and pH variation: the case of 4-ethylresorcinol." IUCrJ 2, no. 5 (2015): 534–44. http://dx.doi.org/10.1107/s2052252515013159.

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This study focuses on the effects of the organic ligand 4-ethylresorcinol on the crystal structure of human insulin using powder X-ray crystallography. For this purpose, systematic crystallization experiments have been conducted in the presence of the organic ligand and zinc ions within the pH range 4.50–8.20, while observing crystallization behaviour around the isoelectric point of insulin. High-throughput crystal screening was performed using a laboratory X-ray diffraction system. The most representative samples were selected for synchrotron X-ray diffraction measurements, which took place a

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40

Samineni, Ramu, Jithendra Chimakurthy, K. Sumalatha, et al. "Co-Crystals: A Review of Recent Trends in Co Crystallization of BCS Class II Drugs." Research Journal of Pharmacy and Technology 12, no. 7 (2019): 3117. http://dx.doi.org/10.5958/0974-360x.2019.00527.4.

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41

Nurzyńska, Katarzyna, Rupert P. Austin, Peter M. Fischer, Jonathan Booth, and Frank Gommer. "Survival of the Fittest: Time-To-Event Modeling of Crystallization of Amorphous Poorly Soluble Drugs." Journal of Pharmaceutical Sciences 105, no. 6 (2016): 1858–66. http://dx.doi.org/10.1016/j.xphs.2016.03.014.

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42

Zhang, Ling, Hanzi Sun, Zhen Chen, Zhengsheng Liu, Niu Huang, and Feng Qian. "Intermolecular Interactions between Coencapsulated Drugs Inhibit Drug Crystallization and Enhance Colloidal Stability of Polymeric Micelles." Molecular Pharmaceutics 14, no. 10 (2017): 3568–76. http://dx.doi.org/10.1021/acs.molpharmaceut.7b00591.

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43

Pajula, Katja, Vesa-Pekka Lehto, Jarkko Ketolainen, and Ossi Korhonen. "Computational Approach for Fast Screening of Small Molecular Candidates To Inhibit Crystallization in Amorphous Drugs." Molecular Pharmaceutics 9, no. 10 (2012): 2844–55. http://dx.doi.org/10.1021/mp300135h.

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44

Lapuk, S. E., T. A. Mukhametzyanov, C. Schick, and A. V. Gerasimov. "Crystallization kinetics and glass-forming ability of rapidly crystallizing drugs studied by Fast Scanning Calorimetry." International Journal of Pharmaceutics 599 (April 2021): 120427. http://dx.doi.org/10.1016/j.ijpharm.2021.120427.

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45

Chernov, A. A., J. J. De Yoreo, L. N. Rashkovich, and P. G. Vekilov. "Step and Kink Dynamics in Inorganic and Protein Crystallization." MRS Bulletin 29, no. 12 (2004): 927–34. http://dx.doi.org/10.1557/mrs2004.262.

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AbstractRevived interest in crystal growth from solutions is driven by a variety of demands, including the need to develop an understanding of biomineralization processes in bones, teeth, and shells;and efforts to characterize large optically nonlinear crystals, perfect crystals of proteins, nucleic acids, and complexes such as viruses. Producing and purifying drugs, food, paint, fertilizers, and other polycrystalline materials in industry are other expanding areas that rely on crystal growth from solution. These general practical incentives have activated in-depth studies that revealed new ph

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46

Varshosaz, Jaleh, Erfaneh Ghassami, and Saeedeh Ahmadipour. "Crystal Engineering for Enhanced Solubility and Bioavailability of Poorly Soluble Drugs." Current Pharmaceutical Design 24, no. 21 (2018): 2473–96. http://dx.doi.org/10.2174/1381612824666180712104447.

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Background: Crystal engineering is dealing with the creation of new structures and new properties in drug molecules through inter-molecular interactions. Researchers of pharmaceutical sciences have used this knowledge to alter the structure of crystalline medications in order to remedy the problems of more than 40% of the new designed drugs which suffer from low solubility and consequently, low bioavailability which have limited their clinical application. Methods: This review covers a broad spectrum of aspects of the application of crystal engineering in pharmaceutics and includes a comprehen

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Matsuura, Shinji, Koichi Igarashi, Masayuki Azuma та Hiroshi Ooshima. "Polymorphic Crystallization Design to Prevent the Degradation of the β-Lactam Structure of a Carbapenem". Crystals 11, № 8 (2021): 931. http://dx.doi.org/10.3390/cryst11080931.

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Abstract:

The cooling crystallization of carbapenem CS-023 was performed at 25 °C in an aqueous solution. Tetrahydrate crystals (form H) were obtained. Hydrate crystals are promising drugs, but there has been problems in manufacturing such crystals. During cooling crystallization, a dissolution process at a high temperature of 70 °C was utilized. The main problem in manufacturing was that the degradation rate of CS-023 at 70 °C was high, as expressed in the half-life period of 2.97 h. Poor solvent crystallization using ethanol was observed at 25 °C. Thus, a different polymorph (Form A) was obtained. For

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Ci, Tianyuan, Yuning Shen, Shuquan Cui, Ruili Liu, Lin Yu, and Jiandong Ding. "Achieving High Drug Loading and Sustained Release of Hydrophobic Drugs in Hydrogels through In Situ Crystallization." Macromolecular Bioscience 17, no. 3 (2016): 1600299. http://dx.doi.org/10.1002/mabi.201600299.

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Sjuts, Hanno, Herman Schreuder, Christian K. Engel, Till Bussemer, and Yatin Gokarn. "Matching pH values for antibody stabilization and crystallization suggest rationale for accelerated development of biotherapeutic drugs." Drug Development Research 81, no. 3 (2019): 329–37. http://dx.doi.org/10.1002/ddr.21624.

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Gu, Tonghan, Eunice W. Q. Yeap, Zheng Cao, et al. "Droplet-Templated Antisolvent Spherical Crystallization of Hydrophilic and Hydrophobic Drugs with an in situ Formed Binder." Advanced Healthcare Materials 7, no. 3 (2017): 1700797. http://dx.doi.org/10.1002/adhm.201700797.

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