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Dissertations / Theses on the topic 'Drugs Crystallization'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Keats, Clare J. "Crystallization and polymorphism of putative drugs." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404167.

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2

Ruiz, Guadalupe Natalia. "Relaxation dynamics and crystallization kinetics of glass-forming drugs." Doctoral thesis, Universitat Politècnica de Catalunya, 2018. http://hdl.handle.net/10803/663205.

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Glassy phases play an important role in our daily life and in many industries such as the food, pharmaceutical, and construction and are responsible for certain vital mechanisms in living species. Whereas crystals are solid phases that show periodicity of the constituent atoms or molecules, glasses are disordered solids that lack long-range positional order but behave mechanically like solids. Chapter 1 of the current thesis presents an introduction to the characteristics and dynamics of glassy phases. How they are derived from the liquid phase, and how they transform into the crystalline soli

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3

Zhou, Jun Hu Zhibing. "Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/permalink/meta-dc-11001.

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4

OLIVEIRA, MARIA J. A. de. "Sintese, caracterizacao e citotoxicidade de hidrogeis polimericos para imobilizacao de farmaco empregado no tratamento de Leihmaniose." reponame:Repositório Institucional do IPEN, 2008. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11749.

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Made available in DSpace on 2014-10-09T12:55:24Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:04:56Z (GMT). No. of bitstreams: 0<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Dissertação (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP<br>FAPESP:06/53634-3

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Strachan, Clare, and n/a. "Spectroscopic investigation and quantitation of polymorphism and crystallinity of pharmaceutical compounds." University of Otago. School of Pharmacy, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070427.141108.

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Spectroscopy is increasingly used to investigate and monitor the solid state forms of pharmaceutical materials and products. Spectroscopy�s speed, nondestructive sampling, compatibility with fibre optics and safety also make it attractive for in-line monitoring. In this thesis, the spectroscopic techniques Fourier transform Raman spectroscopy, terahertz pulsed spectroscopy and second harmonic generation were used to characterise and quantify polymorphism and crystallinity of pharmaceutical compounds. Where possible, the multivariate analysis technique partial least squares was used for quant

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6

Nyamayaro, Kudzanai. "Dissolution control of highly soluble active pharmaceutical ingredients via cocrystallisation." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2673.

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Thesis (MTech (Chemistry))--Cape Peninsula University of Technology, 2017.<br>Crystal engineering involves the manipulation of intermolecular interactions to design functionalised crystalline materials and has proved to be an effective tool for the modification of physicochemical properties of active pharmaceutical ingredients (APIs). In the first section of this study, the aim was to systematically influence the rate of dissolution of a highly soluble active pharmaceutical ingredient using crystal engineering principles. Salicylic acid (SA) was employed as a model API to form multicompon

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7

Ozaki, Shunsuke. "Physicochemical Understanding of Solubility and Supersaturation for the Enhancement of the Oral Absorbability of Poorly Soluble Drugs." Kyoto University, 2015. http://hdl.handle.net/2433/199344.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19020号<br>農博第2098号<br>新制||農||1030(附属図書館)<br>学位論文||H27||N4902(農学部図書室)<br>31971<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授加納健司, 教授宮川恒, 教授三上文三<br>学位規則第4条第1項該当

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8

Zhou, Jun. "Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc11001/.

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Tissue response to PNIPAM and HPC nanoparticles has been studied by implantation method. The results suggest that both PNIAPM and HPC nanoparticles possess good biocompatibility and they may serve as a good carrier for the applications of controlled delivery. Rheological properties of dispersions of IPN microgels composed of PNIPAM and PAAc have been studied. It is found that the IPN microgel dispersion can undergo a sol-gel transition at temperature above 33°C. In vivo drug release experiments suggest that the gelation procedure creates a diffusion barrier and thus leads to slow release. An e

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9

Thakare, Kalpana. "THE EVALUATION OF LARCH ARABINOGALACTAN AS A NEW CARRIER IN THE FORMULATION OF SOLID DISPERSIONS OF POORLY WATER- SOLUBLE DRUGS." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/232942.

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Pharmaceutical Sciences<br>Ph.D.<br>Advanced drug discovery techniques have produced more lipophilic compounds. Formation of an amorphous solid dispersion of such poorly water-soluble drugs improves their solubility and dissolution. This results in greater in vivo bioavailability. Thus, it is one of the recent trends in the development of oral dosage forms. In solid dispersions, the carrier is crucial for ensuring the functionality and stability of these systems. Larch arabinogalactan FiberAid grade (AGF) is generally recognized as safe (GRAS) designated, amorphous polymer. The objective of th

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10

Setiawan, Nico. "UNDERSTANDING THE THERMODYNAMICS AND ORAL ABSORPTION POTENTIAL OF PHARMACEUTICAL AMORPHOUS SOLID DISPERSIONS." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacy_etds/85.

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Supersaturating drug delivery systems, such as amorphous solid dispersions (ASDs), have been used extensively to elevate the apparent solubility and oral bioavailability of poorly water-soluble drugs. However, despite the numerous examples of success in increasing solubility and oral bioavailability using ASDs, physical stability challenges remain as formulators seek to employ high drug loading for cost reduction and improved patient compliance. Therefore, stability in both the solid and solution state must be considered for ASDs to be successful. In the solid state, the drug must remain amorp

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11

Carlert, Sara. "Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-178053.

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The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. In vivo small intestinal precipitation from highly supersaturated solutions of two weakly basic model drugs, AZD0865 and mebendazole, was investigated in humans and canine models. Pote

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12

Ibrahim, Mohamed Asim Y. "Co-processing of drugs and co-crystal formers and its effect on pharmaceutical dosage-form performance. Co-crystallization of urea/ 2-methoxybenzamide, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid systems: Solid-state characterization including imaging, thermal, X-ray and Raman spectroscopic techniques with subsequent evaluation of tableting behaviour." Thesis, University of Bradford, 2008. http://hdl.handle.net/10454/12760.

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This dissertation has focused on the solid-state characterization of different co-crystal system as well as the effect of co-crystallization of these systems on pharmaceutical dosage form performance. Urea/ 2-MB, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid co-crystals were prepared using co-grinding- and co-precipitation techniques. In addition, the synthesis of co-crystals through two novel methods has been demonstrated. This includes compaction and convection mixing. The solid-state characterization of the co-crystals has been carried out using XRPD, Raman sp

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13

Ibrahim, Mohamed Asim Yousif. "Co-processing of drugs and co-crystal formers and its effect on pharmaceutical dosage-form performance : co-crystallization of urea/2-methoxybenzamide, caffeine/malonic acid, caffeine/oxalic acid and theophylline/malonic acid systems : solid-state characterization including imaging, thermal, X-ray and Raman spectroscopic techniques with subsequent evaluation of tableting behaviour." Thesis, University of Bradford, 2008. http://hdl.handle.net/10454/12760.

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This dissertation has focused on the solid-state characterization of different co-crystal system as well as the effect of co-crystallization of these systems on pharmaceutical dosage form performance. Urea/ 2-MB, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid co-crystals were prepared using co-grinding- and co-precipitation techniques. In addition, the synthesis of co-crystals through two novel methods has been demonstrated. This includes compaction and convection mixing. The solid-state characterization of the co-crystals has been carried out using XRPD, Raman sp

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14

Zeng, Jianming. "Constrained crystallization and depletion in the polymer medium for transdermal drug delivery system." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5102.

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Transdermal drug delivery systems (TDS) are pharmaceutical devices that are designed to deliver specific drugs to the human body by diffusion through skin. The TDS effectiveness suffers from crystallization in the patch when they are kept in storage for more than two years. It has been reported that there are two types of crystals in the patch: needle and aggregate, and growth of drug crystals in TDS generally occurs only in the middle third of the polymer layer. In our study, fluorescence microscopy, EDS (SEM) and Raman microspectroscopy were used to further characterize the crystals. The res

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15

Paiva, Lacerda Suênia de. "Improvement of dissolution rate of a new antiretroviral drug using an anti-solvent crystallization technology." Phd thesis, Toulouse, INPT, 2013. http://oatao.univ-toulouse.fr/9301/1/de_paiva_lacerda.pdf.

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This study concerns a new antiretroviral drug named CRS 74. This molecule has a limited bioavailability because of its low aqueous solubility, poor water wettability and low dissolution rate. In an attempt to improve these properties, CRS 74 was recrystallized by using a Liquid Anti-Solvent (LAS) crystallization process. The chosen solvent is the ethanol and the anti-solvent the water. So solid-liquid equilibria in binary mixtures ethanol/water were measured at 30°C. The obtained solubility data were represented using UNIQUACbased model. The experimental and calculated solubilities permitted t

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16

Clogston, Jeffrey. "Applications of the lipidic cubic phase from controlled release and uptake to in meso crystallization of membrane proteins /." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117564268.

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Thesis (Ph.D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xxii, 352 p.; also includes graphics. Includes bibliographical references (p. 346-352). Available online via OhioLINK's ETD Center

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17

Clogston, Jeffrey. "Applications of the lepidic cubic phase: from controlled release and uptake to in meso crystallization of membrane proteins." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1117564268.

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18

Greene, Shaquita T., and Ying Zhang. "HIV-1 PR P51 Mutant Complex Formation with Inhibitors." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_hontheses/4.

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Human Immunodeficiency Virus (HIV) has become a global pandemic with at least 25 million deaths and no cure. One of the most important targets to inhibit this virus is HIV-1 protease (PR), which is required to cleave the viral proteins needed for maturation of the virus after it invades and replicates in the host cell. There are nine protease inhibitors that are used in AIDS treatment. The virus loses susceptibility to these inhibitors by drug resistance due to mutations. The goal of the project is to examine the highly drug resistant HIV PR P51 in its complex with inhibitors. In this experi

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19

Källgren, Joanna. "Strukturella och funktionella studier av fyra enzymer involverade i cellväggsbiosyntes hos Mycobacterium tuberculosis." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264352.

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The pathogenic bacterium Mycobacterium tuberculosis (Mt) is the causative agent of tuberculosis, a widespread and fatal infectious disease. Today, treatment against tuberculosis involves a combination of drugs, which need to be taken for at least six months and which often causes severe side effects. Therefore, new drugs that are more effective and that give fewer side effects are needed. A characteristic feature of the Mt bacterium is its very complex and thick cell wall, which prevents many potential drug molecules from penetrating it. Inhibiting any one of the enzymes that are involved in i

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20

Cui, Yong. "Enhanced Release of Lidocaine From Supersaturated Solutions of Lidocaine In A Pressure Sensitive Adhesive." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054210962.

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21

明, 北山, and Akira Kitayama. "Molecular aspect of interfacial phenomena affecting particle characteristics of drug substances." Thesis, https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13155961/?lang=0, 2020. https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13155961/?lang=0.

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実験・理論・数値シミュレーションに加え，データ科学（統計解析）も含めたアプローチを活用し、低分子医薬品の原薬粒子形態に影響を与える界面現象に対してメカニズムを検討した。具体的には液－液相互拡散を伴う系での相互拡散現象、結晶核生成機構について分子動力学シミュレーション、また粉砕工程での共粉砕物間の固－固界面でのアモルファス化について離散要素法シミュレーションと統計的手法の組合せによる解析を行った。<br>The mechanisms of interfacial phenomena affecting the particle morphology of small-molecule drugs were investigated using experimental, theoretical and numerical simulations as well as data science (statistical analysis). The mechanisms of mutual diffusion and crystal nucleation in systems with liquid-liquid interface were studied by molecular dynamics simulations, and amorphization at the soli

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22

Carriles, Linares Alejandra Ángela. "STRUCTURAL BIOMEDICINE: CHARACTERIZATION OF THE STRUCTURAL BASIS IN PROTEIN-DRUG RECOGNITION IN DIFFERENT HUMAN DISEASES." Doctoral thesis, Universitat Politècnica de València, 2019. http://hdl.handle.net/10251/130844.

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[ES] La cristalografía de rayos X es una potente técnica para la resolución de la estructura atómica de macromoléculas. La información generada, tiene gran impacto sobre diferentes campos relacionados con la investigación básica y aplicada, como son la biomedicina y diseño de fármacos, al igual que en el desarrollo de aplicaciones nanotecnológicas y biotecnológicas. Esta Tesis se centra en determinadas problemáticas actuales y en las proteínas involucradas en las mismas (TryR, eEF1A2 y CBDP35), siendo éstas sujeto de desarrollo biotecnológico en los campos de la biomedicina, farmacia y de la i

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23

Xia, Xin. "Dissolving the Rocks : Solubility Enhancement of Active Pharmaceutical Ingredients using Mesoporous Silica." Doctoral thesis, Stockholms universitet, Institutionen för material- och miljökemi (MMK), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-103190.

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Poor aqueous solubility is one of the greatest barriers for new drug candidates to enter toxicology studies, let alone clinical trials. This thesis focuses on contributing to solving this problem, evaluating the oral toxicity of mesoporous silica particles, and enhancing the apparent solubility and bioavailability of active pharmaceutical ingredients in vitro and in vivo using mesoporous silica particles. Toxicological studies in rats showed that two types of mesoporous silica particles given by oral administration were well tolerated without showing clinical signs of toxicity. Solubility enha

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24

Resende, de Azevedo Jacqueline. "Etude de la cristallisation d’une nouvelle molécule à efficacité cardiotonique dans un mélange liquide ionique - eau." Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2014. http://www.theses.fr/2014EMAC0009/document.

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La cristallisation par effet anti-solvant, comme technique de production de micro/nanoparticules, présente certains inconvénients. En effet, pour des molécules nouvellement synthétisées ou découvertes, comme le LASSBio-294, les solubilités dans l'eau et dans les solvants organiques sont faibles ce qui limite l'application de cette opération. L'utilisation de solvants alternatifs ouvre de nouvelles perspectives de recristallisation de ce type de molécules. Dans ce travail, nous nous sommes intéressés à la cristallisation du LASSBio-294 en utilisant un liquide ionique comme solvant. Ce sont des

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25

Souza, Kellen Christina Dutra de. "Preparação e caracterização de estruturas polimórficas da tolbutamida e nifedipina." Universidade Federal Fluminense, 2005. http://www.bdtd.ndc.uff.br/tde_busca/arquivo.php?codArquivo=1334.

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Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro<br>Neste estudo foram preparados polimorfos do fármaco tolbutamida, um hipoglicemiante oral usado no tratamento dos Diabetes Mellitus tipo II. Foram também preparados polimorfos da nifedipina, fármaco usado no tratamento das desordens cardiovasculares, como angina pectoris e hipertensão. A preparação dos polimorfos foi mediada por solvente, ou seja, foi em função do solvente usado nas etapas de cristalização e de precipitação das espécies. Um método de resfriamento rápido por nitrogênio líquido também foi utilizado.

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26

Matar, Merheb Rachel Rima. "Caractérisation d’une nouvelle génération de détergents stabilisateurs des transporteurs abc en solution : cristallisation de BmrA, transporteur ABC bactérien." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10303.

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En raison de leur résistance aux agents chimiothérapeutiques, les transporteurs ABC de phénotype MDR ont attiré l'attention de la communauté scientifique. Notre projet vise à trouver des conditions dans lesquelles les transporteurs ABC restent fonctionnels en solution pour aboutir à la cristallisation de ces protéines dans une conformation active. Dans ce but, nous avons conçu et développé une nouvelle classe de détergents, à base de calix[4]arène, qui stabilisent ces protéines. Afin de résoudre la structure 3D à résolution atomique du transporteur ABC bactérien "BmrA", responsable de la résis

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Kilburg, Arnaud. "Cristallisation du transporteur ABC BmrA de Bacillus subtilis : développement d’une nouvelle méthode de dosage des détergents par Matrix-Assisted Laser Desorption Ionization (MALDI)." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10116/document.

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Notre projet vise à déterminer la structure 3D du transporteur BmrA de Bacillus subtilis. La protéine a été purifiée dans six détergents différents. L'utilisation de foscholine 12, a conduit à cristalliser OmpF, une porine de la membrane externe d'E. coli. Nous montrons que les conditions de cristallisation influencent directement l'empilement cristallin d'OmpF. Le protocole de purification de BmrA, optimisé en utilisant du triton X100 à l'extraction puis un mélange β-D-dodecyl maltoside-cholate pour les étapes chromatographiques nous a permis d'obtenir à 4°C des cristaux, pour lesquels nous a

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Chou, Shih-Wei, and 周世偉. "The Effect of Additives on Poorly Water-Soluble Drugs by Using the Impinging-Jets Crystallization Technique." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/2redp9.

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碩士<br>國立臺北科技大學<br>化學工程所<br>93<br>The research conducts the study of impinging-jets crystallization for poorly water-soluble drugs by adding additives to improve dissolution rate, thus enhancing the therapeutic effect of drugs. Tolbutamide and phenylbutazone were used as model drugs while hydroxyproplcellulose（HPC）, polyvinylpyrrolidone（PVP）, sodium lauryl sulfate（SDS） and D-mannitol（D-M） were additives used in this work. Also, acetone was the solvent for the drugs, while water was the anti-solvent. In the experiments, different operating variables such as supersaturation as well as the ratios

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Veiga, Cíntia Leonora Semedo. "Evaluation and Prediction of the physical stability of amorphous drugs." Master's thesis, 2019. http://hdl.handle.net/10362/89611.

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The formulation of amorphous solids dispersion (ASDs) is a vanguard strategy used for the improvement of aqueous solubility and bioavailability of poorly water-soluble drugs. During formulation development it is very important to evaluate and predict long term physical stability of ASDs, particularly in supersaturated systems, since these forms are thermodynamically unstable. This project focuses not only on the evaluation of different thermodynamic and kinetics parameters that govern physical stability, but also on the development of a model that can effectively predict long term stability.

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Joubert, Yolandi. "Automated structural annotation of the malaria proteome and identification of candidate proteins for modelling and crystallization studies." Diss., 2008. http://hdl.handle.net/2263/26807.

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Malaria is the cause of over one million deaths per year, primarily in African children. The parasite responsible for the most virulent form of malaria, is Plasmodium falciparum. Protein structure plays a pivotal role in elucidating mechanisms of parasite functioning and resistance to anti-malarial drugs. Protein structure furthermore aids the determination of protein function, which can together with the structure be used to identify novel drug targets in the parasite. However, various structural features in P. falciparum proteins complicate the experimental determination of protein three dim

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Chen, Chong-Shou, and 陳重守. "Systematic Screening of Drug Substances for Polymorphs Using Crystallization Techniques." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/xkp55v.

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碩士<br>國立臺北科技大學<br>化學工程所<br>94<br>The purpose of this research is to establish a systematic methodology to screen polymorphic forms of drug substances through the use of crystallization techniques. In this study, tolbutamide was used as a model drug and three different approaches of crystallization methods including cooling crystallization, salting out crystallization, and melting crystallization were used to search for various polymorphs. In cooling crystallization, water and twelve organic solvents of different functional groups and polarity were chosen for systematic screening with three coo

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Liang, Chun Ming, and 梁峻銘. "Screening Polymorphic Forms of Drug Substances by Using Generalized Crystallization Techniques." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/466vhj.

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碩士<br>國立臺北科技大學<br>化學工程研究所<br>95<br>The purpose of this study is to screen polymorphic forms of drug substances through the use of generalized crystallization techniques. Chlorpropamide was used as a model drug and three different crystallization methods including cooling crystallization, salting out crystallization, and melting crystallization were used to search for various polymorphs. In cooling crystallization, thirteen solvents with different polarity and functional groups were chosen for the recrystallization process under different cooling rates. In salting out crystallization, water and

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Lin, Chih Cheng, and 林志誠. "Improvement of the Micromeritic Characteristics and the Dissolution Rate of Drug Crystals by the Spherical Crystallization Technique." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/69458328931997569402.

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碩士<br>國立臺北科技大學<br>化學工程系碩士班<br>91<br>Crystallization is a significant separation technique which is often used in pharmaceutical industry. This method not only isolates drug substances with high purity directly from the solution, but improves the micromeritic characteristics and the quality of the drug products. Many of the drug substances are poorly soluble in water or gastrointestinal fluids. Considerable attention is therefore placed to reduce the particle size by milling steps to enhance the bioavailability. However, the fine crystals with poor flowability, packability and compressibility m

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Cho, Bee Ah. "Solubility and crystallization of fentanyl in polyisobutylene films parameters that control the stability of a drug in adhesive system." 2001. http://catalog.hathitrust.org/api/volumes/oclc/68914877.html.

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(8715135), Siddhi-Santosh Hate. "DISSOLUTION AND MEMBRANE MASS TRANSPORT OF SUPERSATURATING DRUG DELIVERY SYSTEMS." Thesis, 2020.

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<p>Supersaturating drug delivery systems are an attractive solubility enabling formulation strategy for poorly soluble drugs due to their potential to significantly enhance solubility and hence, bioavailability. Compendial dissolution testing is commonly used a surrogate for assessing the bioavailability of enabling formulations. However, it increasingly fails to accurately predict <i>in vivo</i> performance due its closed-compartment characteristics and the lack of absorptive sink conditions. <i>In vivo</i>, drug is continually removed due to absorption across the gastrointestinal membrane, w

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Mahapatra, Sudarshan. "Synthesis, Structure And Photocatalysis Of Orthovanadates, Novel Approaches For The Crystallization Of Anhydrous Nucleobases And Ab Initio Structure Determination Of A Drug Intermediate From Powder X-ray Diffraction Data." Thesis, 2008. http://hdl.handle.net/2005/910.

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The thesis begins with a brief introduction and relevant literature references. The novelty of synthesis, methodology and results of the work reported in the thesis and highlighted subsequently. The thesis consist of three parts, Part A of the thesis consist of five chapters describing new methods of synthesis of orthovanadates, mainly dealing with the structure and photocatalytic properties of synthesized materials. Part B of the thesis consist of two chapters dealing with an unique crystallization methodology for subliming and low melting organic compounds and the crystal structure determina

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Schimer, Jiří. "Nové inhibitory HIV proteasy: návrh, synthesa a testování aktivity." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-297243.

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More than 20 years after its discovery HIV protease still remains one of the primary targets in HIV treatment. Currently there are 9 approved protease inhibitors on the market. However, due to immense replication rate and the high error prone nature of reverse transcriptase, resistance to each of them has already been described. Therefore, the search for new protease inhibitors with different binding mode is still active. A novel type of protease inhibitors (1, 4-benzodiazepine analogs) was recently discovered in our laboratory. Even though this new class of inhibitors is highly potent (Ki' in

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38

Graubner, Gitte. "Crystal Engineering in Nanoporous Matrices." Doctoral thesis, 2015. https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2015021213062.

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As former studies reveal, the nanoporous confinement could have influence on polymorphic drug crystallization. However, little attention has been paid to the question how crystallization of the commonly polymorphic drugs in nanoporous matrices influences the drug release. As a consequence, sufficient information about the crystallization conditions and their influence on phase behavior, crystal texture, and stability of polymorphs should be retrieved prior to drug delivery experiments. Drug release should be polymorph-selective and even crystal face-specific. Therefore, the topic of this PhD t

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39

Barker, Megan. "Structural Investigation of Processing α-Glucosidase I from Saccharomyces cerevisiae". Thesis, 2010. http://hdl.handle.net/1807/32660.

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N-glycosylation is the most common eukaryotic post-translational modification, impacting on protein stability, folding, and protein-protein interactions. More broadly, N-glycans play biological roles in reaction kinetics modulation, intracellular protein trafficking, and cell-cell communications. The machinery responsible for the initial stages of N-glycan assembly and processing is found on the membrane of the endoplasmic reticulum. Following N-glycan transfer to a nascent glycoprotein, the enzyme Processing α-Glucosidase I (GluI) catalyzes the selective removal of the terminal glucose re

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