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Dissertations / Theses on the topic 'Engraftment'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Pepperell, Emma E. "The regulation of stem cell engraftment." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:873a14b9-6c7b-4643-bb34-4e1679d4f734.

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The engraftment of haemopoietic stem/progenitor cells (HSPCs) from umbilical cord blood (UCB) into adult recipients, although advantageous in terms of sourcing units, the decreased need to match donor and recipient and reduced risk of graft versus host disease (GvHD), is delayed compared to grafts using HSPCs from mobilised peripheral blood (MPB) or bone marrow (BM). One reason for this is the limited number of HSPCs (CD34+/CD133+ cells) in a unit of UCB compared to MPB or BM. The CXCR4-CXCL12 axis is widely recognised as a key player in the bone marrow homing, retention, and engraftment of HS

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2

Escobedo, Cousin M. H. "Ancillary cell help in haematopoietic cord blood engraftment." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1424406/.

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Cord blood (CB) has served as a source of haematopoietic stem cells (HSC) to treat haematological diseases for the last two decades. Low incidence and severity of graft-versus-host disease, and a robust graft-versus-leukaemia effect are some of CB advantages as a source for HSC. However, its main disadvantages are a limited number of HSC per unit and delayed immune reconstitution and infections after CB transplantation (CBT). In order to improve engraftment and immune reconstitution after CBT different approaches have been explored like HSC expansion, double CB transplantation, CBT plus third

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3

Chu, Jennifer. "Enhanced engraftment of genetically modified bone marrow stromal cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58851.pdf.

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4

Lee, I.-Hui. "On CNS injury and olfactory ensheathing cell engraftment strategies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-551-8/.

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5

He, Zhong. "Modifying xenogeneic immune recognition and engraftment by genetic engineering /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-353-1/.

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6

Tsaknakis, Grigorios. "Molecular mechanisms of stem cell migration, homing and engraftment." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497129.

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7

Takemoto, Naohiro. "Protective Strategies for Enhancing Engraftment of Insulin Releasing Cells." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188602.

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8

Colletti, Evan. "Human mesenchymal stem cell engraftment in the chimeric sheep model." abstract and full text PDF (free order & download UNR users only), 2006. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3209960.

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9

Ahmed, Forhad. "Homing and engraftment of CD34+ cells in the NOD/SCID model." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445284/.

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The reduced engraftment potential of haemopoietic stem/progenitor cells after exposure to cytokines may be related to the impaired homing ability of actively cycling cells. I tested this hypothesis by quantifying the short-term homing of human adult CD34+ cells in NOD/SCID animals. I have demonstrated in adult CD34+ cells that cytokine exposure ex-vivo leads to a loss of engraftment ability in vivo which occurs rapidly and which is associated with a striking alteration in the tissue distribution of homed cells. Loss of homing to the BM and to a lesser extent, the spleen, coincides with increas

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10

Liu, Wei. "Rational targeting of Cdc42 in hematopoietic stem cell mobilization and engraftment." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1303845649.

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11

Rao, Krithika. "Epicardial Cell Engraftment And Signaling Promote Cardiac Repair After Myocardial Infarction." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/479.

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The epicardium is a single layer of epithelial (mesothelial) cells that covers the entire heart surface, but whose function in adult mammals is poorly understood. Defining the role of epicardial cells during homeostasis, growth and injury has potential to provide new treatment strategies for human diseases that result in heart failure, due to extensive loss of viable cardiac tissue. We hypothesized that epicardial cells contribute to repair as transplantable progenitor cells for cellular regeneration and as a source of secreted growth factors for cell protection after myocardial infarction. Ad

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12

Uonaga, Taeko. "FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation modeｌ". Kyoto University, 2011. http://hdl.handle.net/2433/135378.

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13

Newsome, Philip N. "Studies on cellular engraftment and hepatocytic differentiation in liver injury and repair." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/27118.

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<i>Aim: </i>In this thesis the factors which regulate the adhesion and survival of hepatocytes in the face of acute liver injury environment are examined. Also factors which regulate the differentiation of human stem cells towards hepatocytes are examined <i>in vitro</i> and <i>in vivo</i>. <i>Materials and Methods: </i>Human hepatoblastoma (HepG2) cells were used as a model of human hepatocytes to study the effect of serum from patients with acute liver failure. Various laboratory assays were used to determine effects on adhesion, cell necrosis/apoptosis, integrin expression (flow cytometry)

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14

Lau, Joey. "Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8418.

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15

Wagar, Eric James. "Human Lymphocyte Engraftment and Function in HU-PBL-SCID Mice: a Dissertation." eScholarship@UMMS, 2000. http://escholarship.umassmed.edu/gsbs_diss/286.

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The immune system is responsible for defending a host animal from a wide variety of threats. Manipulation of the immune system can result in beneficial outcomes such as immunity to pathogens, or deleterious outcomes such as autoimmunity. Advances in our understanding of how the immune system develops and functions have benefited greatly from studies in animals, particularly in mice where the genetics are well known and a multitude of reagents are readily available for experimental use. Although much has been learned from animal experimentation, it must be cautioned that animals are not humans.

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16

Watts, Michael John. "Human haemopoietic progenitor cell mobilization." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313428.

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17

Mattsson, Jonas. "Molecular monitoring of engraftment and leukemia relapse after allogeneic hematopoietic stem cell transplantation /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4757-0/.

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18

Elsammak, Mohamed. "Novel strategies for the enhancement of stem cell engraftment following in utero transplantation." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364425.

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19

Doreste, Gonzalez Bruno. "The effect of modulating the dystrophic skeletal muscle environment on satellite cell engraftment." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10051216/.

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Satellite cells derived from normal donor mice contribute to muscle regeneration and restore dystrophin expression when transplanted into dystrophin-deficient mice (mdxnu/nu). However, unless the local host muscle environment has been modulated with high doses of gamma-radiation to incapacitate host satellite cells, but maintaining a functional niche, donor satellite cell engraftment is negligible. This work aimed to determine the cells and pathway(s) within host muscle which are responsible for mediating the radiation-induced effect. I first investigated whether this effect was mediated by ap

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20

Tomsitz, Dirk [Verfasser]. "Untersuchungen zum Engraftment primärer humaner akuter myeloischer Leukämieblasten in einem immundefizienten Mausmodel / Dirk Tomsitz." Mainz : Universitätsbibliothek Mainz, 2012. http://d-nb.info/1024434990/34.

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21

Sakai, Hiroshi. "Fetal Skeletal Muscle Progenitors Have Regenerative Capacity After Intramuscular Engraftment in Dystrophin Deficient Mice." Kyoto University, 2013. http://hdl.handle.net/2433/180347.

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22

Funakoshi, Shunsuke. "Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes." Kyoto University, 2016. http://hdl.handle.net/2433/215421.

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23

Bartlett, David Christopher. "The role of adhesion molecule interactions in the engraftment of transplanted hepatocytes into host liver." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6041/.

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Orthotopic liver transplantation (OLT) remains the only proven treatment for end-stage liver disease. However the waiting list for OLT far exceeds the supply of donor organs. Hepatocyte transplantation may offer an alternative for these patients either as a bridge to OLT or replacing OLT altogether. Unfortunately efforts so far have failed to result in long term benefit despite initial promising results. The mechanisms regulating engraftment of transplanted hepatocytes into host liver, in particular the nature of their interaction with hepatic sinusoidal endothelial cells (HSEC), remain poorly

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24

Xu, Haiming. "Loss of the Rho GTPase Activating Protein p190-B enhances hematopoietic stem cell engraftment potential." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211979515.

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25

Tabayoyong, William Borj. "Engraftment of embryonic stem cell-derived hematopoietic progenitor cells is regulated by natural killer cells." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1089.

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Embryonic stem (ES) cells possess the remarkable ability to form cells and tissues from all three germ layers, a characteristic known as pluripotency. In particular, the generation of ES cell-derived hematopoietic cells could serve as an alternate source of hematopoietic stem cells for transplantation in place of bone marrow cells, which are limited by donor availability and high immunogenicity. The advantages of ES cell-derived hematopoietic cells over bone marrow cells include a greater proliferative capacity, which alleviates the problems of donor shortage, and low level expression of MHC a

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26

Wong, Mei-yi, and 王美兒. "Improving engraftment potential of hMSCs after encapsulation in collagen microsphere: an in vitro and in vivostudy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47753080.

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Stem cell-based therapies are promising in regenerative medicine. However, the success of cell therapy is greatly limited by the low engraftment rate to the target tissues. The present study demonstrated that human mesenchymal stem cells (hMSCs) were subjected to a self selection process via microencapsulation in collagen barrier when they were induced to migrate out from this barrier. While retaining the immuophenotype and self renewal capacity, the selected hMSCs showed a significantly better in vitro migratory response of than those cultured in traditional monolayer. The migratory

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27

Kallinikou, K. "Mechanisms underlying cytokine-induced changes in homing and engraftment of human haemopoietic stem and progenitor cells." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1396008/.

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The reduced engraftment potential of cytokine cultured haemopoietic stem/progenitor cells from adult mobilised peripheral blood has been associated with their defective homing to bone marrow niches. In this work, using established in vivo systems and a novel ex vivo model, an additional cytokine-induced attachment defect is described that reduces the retention of these cells in the bone marrow, post-transplantation. This defect was found to be related to specific niche ligands and was not caused by downregulation of their respective receptors on the expanded cells. CD26 is a protease that clea

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28

Chacko, Simi M. "Stem Cell Therapy for Myocardial Infarction: Overcoming the Hypoxic Impediment to Enhance Cell-survival and Engraftment." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243970807.

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29

Cochonneau, Stéphanie. "Modulating hematopoietic progenitor cell engraftment and T cell differentiation : role of conditioning and route of administration." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20226.

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Les déficits lymphocytaires T peuvent être corrigés par l'administration en intraveineuse (IV) de cellules souches hématopoiétiques (CSH) provenant d'un donneur. Dans un modèle d'immunodéficience lié à l'absence de la protéine kinase ZAP-70, notre équipe avait précédemment montré que l'injection intrathymique (IT) de CSH histocompatibles conduit à une reconstitution du compartiment T plus robuste et plus rapide que dans le cas où les CSH sont administrées par voie IV. Au cours de ma thèse, je me suis intéressée à l'approche IT dans un contexte non-histocompatible, où j'ai montré que l'injectio

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30

Johansson, Åsa. "Properties of Endothelium and its Importance in Endogenous and Transplanted Islets of Langerhans." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109713.

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Transplantation of insulin producing cells is currently the only cure for type 1 diabetes. However, even though the Edmonton protocol markedly increased the success rate of pancreatic islet transplantation, the long term insulin independence is still very poor. An adequate engraftment is critical for islet graft survival and function. In the present thesis, isolated islet endothelial cells were found to have a low proliferatory and migratory capacity towards vascular endothelial growth factor (VEGF), but this could be reversed by using neutralizing antibodies to the angiostatic factors thrombo

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31

呂景希 and King-hei Crosby Lu. "A single centre, randomised trial on harvest cell yield and marrow engraftment using haemopoietic growth-factor primed bone marrow." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970746.

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32

Hancock, Jeremy Paul. "The interplay of engraftment chimaerism and clinical outcome in children undergoing allogeneic bone marrow transplantation for acute lymphoblastic leukaemia." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368456.

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33

Lin, Yuan. "In Vivo Imaging of Engraftment and Enrichment of Lentiviral Transduced Hematopoietic Bone Marrow Cells Under MGMT-P140K Mediated Selection." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1295039430.

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34

Lu, King-hei Crosby. "A single centre, randomised trial on harvest cell yield and marrow engraftment using haemopoietic growth-factor primed bone marrow." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25176481.

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35

Ishikawa, Yuki. "Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD/LtSzscid/IL-2Rγ-/- mice". Kyoto University, 2015. http://hdl.handle.net/2433/195963.

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36

Höpfl, Josef. "Untersuchung von Imatinib-Resistenzmechanismen im syngenen Mausmodell der CML sowie des Einflusses von Imatinib auf das Engraftment nach Stammzelltransplantation syngener Mäuse." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980301564.

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37

Begemann, Philipp G. C. "Thrombozyten-Engraftment nach allogener Knochenmarktransplantation und Ex-vivo-Expansion normaler menschlicher Megakaryozyten-Progenitorzellen aus CD34+-angereicherten Knochenmarkzellen gesunder Spender in Flüssigkulturen." [S.l.] : [s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=959425721.

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38

LIANG, YING. "GENETIC REGULATION OF HEMATOPOIETIC STEM CELL NUMBERS IN MICE." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_diss/418.

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Hematopoietic stem cells (HSCs) transplantations are widely used for the treatment of hematological and non-hematological disorders in clinic. Successful transplantation requires sufficient number and efficient homing of HSCs. Many studies have focused on developing an effective strategy to expand functional HSC population. Some regulatory molecules have been recently shown great promise for controlling the amplification of HSCs. In these dissertation studies, I first aim to identify gene(s) and their allelic variants contributing to strain-specific difference in HSC numbers between C57BL/6 (B

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39

Shrestha, Archana. "Mechanism of Human Hematopoietic Stem Cell Loss During Ex Vivo Manipulation and Gene Transfer." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479814903587501.

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40

Espes, Daniel. "Engraftment of Pancreatic Islets in Alternative Transplantation Sites and the Feasibility of in vivo Monitoring of Native and Transplanted Beta-Cell Mass." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282953.

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Islet transplantation is a possible curative treatment for type 1 diabetes (T1D). Currently the liver dominates as implantation site, despite the many challenges encountered at this site. Acute hypoxia in islets transplanted to muscle and omentum, two possible alternative sites, was prevailing. However, it was rapidly reversed at both implantation sites, in contrast to when islets were transplanted intraportally. At the intramuscular site hypoxia was further relieved by co-transplantation of an oxygen carrier, polymerized hemoglobin, which also improved the functional outcome. The complement s

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41

Li, Pulin. "Chemical Genetics of Hematopoietic Stem Cell Transplantation." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10306.

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Hematopoietic stem and progenitor cells (HSPCs) repopulate the blood system upon transplantation. A large-scale genetic approach to understand the factors that participate in successful engraftment has not been undertaken. In this thesis, I present the development of a novel live imaging-based competitive marrow repopulation assay in adult zebrafish, which allows fast and quantitative measurement of HSPC engraftment capability. Using this assay, a transplantation-based chemical screen was performed, which led to the discovery of 10 compounds that can enhance the marrow engraftment capability i

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42

Kollar, Katarina. "The molecular mechanisms utilised by mesenchymal stem cells in migration to acute myocardial infarction." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/41698/1/Katarina_Kollar_Thesis.pdf.

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Heart damage caused by acute myocardial infarction (AMI) is a leading cause of death and disability in Australia. Novel therapies are still required for the treatment of this condition due to the poor reparative ability of the heart. As such, cellular therapies that assist in the recovery of heart muscle are of great current interest. Culture expanded mesenchymal stem cells (MSC) represent a stem and progenitor cell population that has been shown to promote tissue recovery in pre-clinical studies of AMI. For MSC-based therapies in the clinic, an intravenous route of administration would ideall

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43

Ghiaur, Gabriel. "The role of Rho GTPases in hematopoietic stem cell biology RhoA GTPase regulates adult HSC engraftment and Rac1 GTPases is important for embryonic HSC /." Cincinnati, Ohio : University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1204374567.

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44

Mohanty, Sindhu Tanaya. "A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion and engraftment to bone marrow in NOD/SCID mice." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7460/.

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Human mesenchymal stem cells (hMSCs) have been shown to have potential in regenerative approaches in bone and blood. Most protocols rely on their in vitro expansion prior to clinical use. However, several groups including our own have shown that hMSC lose proliferation and differentiation ability with serial passage in culture, limiting their clinical applications. Cellular prion protein (PrP) has been shown to enhance proliferation and promote self-renewal of hematopoietic, mammary gland and neural stem cells. With this work I tested the hypothesis that PrP decreased with cellular ageing of h

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45

Varagnolo, Linda [Verfasser], and Albrecht Manfred [Gutachter] Müller. "PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem/progenitor cells / Linda Varagnolo. Gutachter: Albrecht Manfred Müller." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1111560021/34.

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46

Packthongsuk, Kreeson. "Detection of porcine umbilical cord matrix stem cells in the intestine and other organs after oral and intraperitoneal administration to allogeneic recipients." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/16753.

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Doctor of Philosophy<br>Department of Animal Sciences and Industry<br>Duane Davis<br>Umbilical cords matrix stem cells (UCs) have been characterized most thoroughly in humans (HUCs) and are considered to have great promise for regenerative medicine and cell-based therapy. Although UCs were first identified in pigs the description of porcine UCs (PUCs) is limited. Here we reported some standard mesenchymal stem cell characteristics for PUCs. Development of knowledge about PUCs is useful because the pig is a valuable biomedical model for humans and the species is an important human food source.

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47

Hengstenberg, Skadi [Verfasser]. "Analyse verschiedener Einflussfaktoren auf das Gesamtüberleben und das rezidivfreie Überleben sowie auf das Leukozyten- und das Thrombozyten-Engraftment nach autologer oder allogener Transplantation hämatopoetischer Stamm- und Progenitorzellen. / Skadi Hengstenberg." Kiel : Universitätsbibliothek Kiel, 2014. http://d-nb.info/1054636060/34.

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48

Fortin, Pierre-Yves. "Adressage d’un gène à une tumeur via des cellules sanguines circulantes : contrôle de l’expression par hyperthermie locale et suivi par imagerie." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21827/document.

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Les thérapies géniques et cellulaires ouvrent de nouvelles perspectives pour le traitement de pathologies très diverses. Cependant, l’adressage à un organe cible, le contrôle non invasif de l’expression d’un transgène et le suivi par imagerie constituent encore des défis majeurs pour le développement de ces approches thérapeutiques. L’utilisation d’un vecteur cellulaire modifié génétiquement pour exprimer un transgène spécifique semble une solution prometteuse mais il convient aussi de restreindre l’expression du transgène à la région cible et de contrôler l’expression génique dans le temps. P

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49

Olsson, Richard. "The Microvasculature of Endogenous and Transplanted Pancreatic Islets : Blood Perfusion, Oxygenation and Islet Endocrine Function." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7107.

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50

Karaivanova, Daniela Stefanova [Verfasser], Christian [Gutachter] Teschendorf, and Anke Claudia [Gutachter] Reinacher-Schick. "Einfluss der Dosis von CD 34+ -Blutstammzellen auf das Engraftment nach autologer Stammzelltransplantation in Abhängigkeit vom Körpergewicht bzw. idealisierten Körpergewicht / Daniela Stefanova Karaivanova ; Gutachter: Christian Teschendorf, Anke Claudia Reinacher-Schick ; Medizinische Fakultät." Bochum : Ruhr-Universität Bochum, 2012. http://d-nb.info/1226426417/34.

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