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Journal articles on the topic 'Engraftment'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Unal, Ali, Leylagül Kaynar, Esra Yıldızhan, et al. "The Comparison of Melphalan Administration on Day 3 with Administration on Day 1 on Neutrophil and Platelet Engraftment in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation." Blood 132, Supplement 1 (2018): 5767. http://dx.doi.org/10.1182/blood-2018-99-115353.

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Abstract Objective: High dose chemotherapy followed by ASCT is the most important step of MM treatment. Melphalan, an alkylating agent, is the most preferable drug for conditioning regimens and dosage and timing is important with regards to side effects or engraftment timing. Engraftment time is determinative on infections and hospitalization duration. Methods: We compared the neutrophil and thrombocyte engraftments retrospectively in patients with multiple myeloma who received melphalan 200 mg/m2 single dose on day -3 and day -1 as conditioning regimen. There were 29 patient receiving melphal

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Unal, A., L. Kaynar, N. Keni, et al. "The Comparison of Melphalan Administration on Day −3 With Administration on Day −1 on Neutrophil and Platelet Engraftment in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation." Journal of Global Oncology 4, Supplement 2 (2018): 218s. http://dx.doi.org/10.1200/jgo.18.88300.

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Background: High dose chemotherapy followed by ASCT is the most important step of MM treatment. Melphalan, an alkylating agent, is the most preferable drug for conditioning regimens and dosage and timing is important with regard to side effects or engraftment timing. Engraftment time is determinative on infections and hospitalization duration. Aim: To compare of the neutrophil and thrombocyte engraftment time in patients with multiple myeloma who received melphalan 200 mg/m2 single dose on day −3 and day −1 as conditioning regimen. Methods: We compared the neutrophil and thrombocyte engraftmen

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Unal, A., A. Birekul, L. Kaynar, B. Eser, and M. Cetin. "Successful Treatment With Granulocyte Transfusion and Early Neutrophil Engraftment in Allogeneic Transplant Patients With Febrile Neutropenia: Does Granulocyte Transfusion Effect on Neutrophil Engraftment?" Journal of Global Oncology 4, Supplement 2 (2018): 225s. http://dx.doi.org/10.1200/jgo.18.91100.

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Background: Febrile neutropenia is very severe and urgent early complication after bone marrow transplantation before engraftment. Infection delays engraftments in these periods. Aim: In this study we evaluated the effect and outcome of granulocyte transfusion on febrile neutropenia and neutrophil engraftment in patients receiving allogeneic transplantation. The reasons for the use of the granulocyte transfusion were prolonged febrile neutropenia episode. Methods: Between 2015-2017, 16 patients receiving allogeneic bone marrow transplantation (BMT) were treated with granulocyte transfusion at

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4

Korovin, Sergii, Vasyl Ostafiichuk, Serhii Diedkov, and Mariia Kukushkina. "Experience of Vacuum-Assisted Closure in the Surgical Treatment of Malignant Skin Tumors after Skin Grafting." Open Access Macedonian Journal of Medical Sciences 10, B (2022): 2520–22. http://dx.doi.org/10.3889/oamjms.2022.11046.

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BACKGROUND: Skin grafts may be used to reconstruct large skin defects after the excision of malignant skin tumors. Vacuum-assisted closure (VAC) leads closer approximation of the free flap. AIM: The objective of this study was to estimate the engraftment of grafts using VAC and explore factors influencing this process. MATERIALS AND METHODS: This study included 31 patients with skin cancers after a wide tumor excision. The wound defects were closed using a split-thickness skin graft and the VAC dressing. RESULTS: Complete and partial engraftment was observed in 17 (54.8 %) and 14 (45.2%) cases

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Zheng, Nancy (Xiaoqing), Guoxiang Yang, James Keck, and Li-Chin Yao. "Abstract 7235: New mouse strain NSG-SGM3xIL15xDKO is better for PBMC engraftment in Raji-bearing mice of minor immune subsets compared to NSG-MHC I/II DKO mouse." Cancer Research 85, no. 8_Supplement_1 (2025): 7235. https://doi.org/10.1158/1538-7445.am2025-7235.

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Abstract Introduction: PBMC-humanized MHC I/II double knock-out (#025216, DKO) strain has shown strong T cell engraftment with minimal acute GVHD. We recently have developed two new mouse strains, NSG-SGM3xIL15xDKO (SDKO) and NSG-FLT3LxDKO (FDKO), and their engraftment comparison data will be presented in the same meeting. Here we aimed to investigate the engraftment of various immune cell types in SDKO and FDKO mice in the presence of tumor stimulation. Methods: We assessed PBMC engraftment levels and immune subtypes in irradiated SDKO, FDKO, and DKO implanted with lymphoma (Raji-luc and Nalm

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6

İTMEÇ, Yeşim, Serhat ÇELİK, and Ali ÜNAL. "The effect of granulocyte transfusion on engraftment in patients with allogeneic hematopoietic stem cell transplantation." Journal of Health Sciences and Medicine 6, no. 3 (2023): 674–79. http://dx.doi.org/10.32322/jhsm.1275159.

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Aim: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is still one of the most effective treatments for many hematological malignancies. However, especially infections and neutropenic fever increase mortality during the engraftment development process after allo-HSCT. This study investigated the effect and safety profile of granulocyte transfusion (GT) on engraftment in patients with neutropenic fever after allo-HSCT. Material and Method: We investigated 32 patients with hematological malignancies who had neutropenic fever following allo-HSCT between June 2018 and February

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7

Marzorati, Simona, Raffaella Melzi, Antonio Citro, et al. "Engraftment Versus Immunosuppression." Transplantation 97, no. 10 (2014): 1019–26. http://dx.doi.org/10.1097/tp.0000000000000104.

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8

Summers, E., M. A. Frey, and J. Kurtzberg. "414: Engraftment syndrome." Biology of Blood and Marrow Transplantation 13, no. 2 (2007): 148. http://dx.doi.org/10.1016/j.bbmt.2007.01.044.

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9

Kawashima, Naomi, Satoshi Nishiwaki, Seitaro Terakura, et al. "Impact of Macrophage Activation on Delayed Engraftment Following Allogeneic Hematopoietic Stem Cell Transplantation: Mac Ratio, a New Predictive Index." Blood 122, no. 21 (2013): 4527. http://dx.doi.org/10.1182/blood.v122.21.4527.4527.

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Introduction Delayed engraftment and subsequent engraftment failure cause fatal complications including severe infection and lead to poor prognosis after allogeneic hematopoietic stem cell transplantation (allo-SCT). We have previously reported that hemophagocytic syndrome (HPS) induced by uncontrolled macrophage activation in bone marrow had high mortality due to engraftment failure (BMT.2012;47:387–394). Macrophages are phagocytic cells with abilities of phagocytosis, antigen-presenting, and secretion of cytokines. Although phagocytosis reflects only a part of their activation, their morphol

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10

Zheng, Nancy (Xiaoqing), Kevin Tsai, Guoxiang Yang, et al. "Abstract 7230: New mouse strains NSG-SGM3xIL15xDKO and NSG- FLT3LxDKO are superior to NSG-MHC I/II DKO mice for humanization of peripheral blood mononuclear cells." Cancer Research 85, no. 8_Supplement_1 (2025): 7230. https://doi.org/10.1158/1538-7445.am2025-7230.

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Abstract Background: Peripheral blood mononuclear cells (PBMC)-humanized mice serve as important platforms to evaluate efficacy and toxicity. NSG-MHC I/II double-knock out (DKO) mice have been widely used due to being a humanized T cell model with delayed graft-versus-host disease. However, achieving at least 5% engraftment within a week requires 10-15e6 PBMCs per mouse with irradiation, which accelerates PBMCs to engraft compared to non-irradiated mice. Additionally, engraftment of certain cell populations, such as natural killer (NK) cells and monocytes from PBMC has been challenging in the

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11

Fewkes, Natasha M., Aviva C. Krauss, Martin Guimond, Joanna L. Meadors, Stefania Dobre, and Crystal L. Mackall. "Pharmacologic modulation of niche accessibility via tyrosine kinase inhibition enhances marrow and thymic engraftment after hematopoietic stem cell transplantation." Blood 115, no. 20 (2010): 4120–29. http://dx.doi.org/10.1182/blood-2009-10-248898.

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Abstract Essential survival signals within hematopoietic stem cell (HSC) and thymic niches are mediated by receptor tyrosine kinases, which can be reversibly inhibited using clinically available drugs. We studied whether sunitinib, a multityrosine kinase inhibitor that inhibits KIT, enhances engraftment after bone marrow transplantation (BMT) in mice. Sunitinib diminished hematopoietic progenitor cell numbers, and sunitinib enhanced marrow, peripheral myeloid, and lymphoid engraftment after BMT in Rag1−/− mice. Sunitinib augmented HSC engraftment because recipients displayed increased myeloid

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12

Soydan, Ender A., Pervin Topcuoglu, Muhit Ozcan, et al. "The Impact of Methylenetetrahydrofolate Reductase C677T Gene Polymorphism on Engraftment after Allogeneic Hematopoetic Cell Transplantation." Blood 106, no. 11 (2005): 5318. http://dx.doi.org/10.1182/blood.v106.11.5318.5318.

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Abstract Methotrexate (MTX) is an antifolate agent used to prevent graft versus host disease (GVHD) in allogeneic hemapoietic cell transplantation (AHCT). The effectiveness of MTX is largely attributable to its role of MTHR and its gene polymorphism is a common (10–12% homozygote and 40% heterozygote) variation in the population. It was shown by Ulrich et al that C677T polymorphism leads to variations in toxicities. Depending on to this finding, we investigated whether methylenetetrahyrofolate reductase (MTHFR) C677T gene polymorphism has any affect on engraftment kinetics of patients undergoi

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13

WANG, Jing, Xiao-Jun HUANG, Lan-Ping XU, et al. "Monitoring the source of mesenchymal stem cells in patients after transplantation of mismatched-sex hematopoietic stem cells plus third-party cells." Chinese Medical Journal 126, no. 22 (2013): 4254–59. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20131172.

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Background In bone marrow transplant patients, the microenvironment in bone marrow is damaged after chemotherapy or radiotherapy. Subsequent to allogenic hematopoietic stem cell transplantation in patients with clinically successful engraftments, the source of mesenchymal stem cells (MSCs) remains controversial. To further verify the stimulatory effect of the simultaneous transplantation of cells from second donors on engraftment success for hematopoietic stem cell transplantation in support of donor MSCs engraftments, the aim of this study is to monitor the dynamics of the engraftment of bone

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14

Waller, Anthony F., Fengrong Wang, and Ned Waller. "A Mathematical Model of Stochastic Engraftment by Non-Interacting Single Umbilical Cord Blood (UCB) Grafts Predicts Accelerated Engraftment Using Multiple UCB Grafts." Blood 110, no. 11 (2007): 2034. http://dx.doi.org/10.1182/blood.v110.11.2034.2034.

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Abstract Background: The use of UCB transplants is limited by the difficulty of finding units with sufficient cells to provide reliable engraftment, and the slower kinetics of hematopoietic engraftment compared to other hematopoietic progenitor cell grafts. Grafts consisting of two unrelated UCB result in accelerated engraftment compared to single unit UCB transplants, but the mechanism for enhanced engraftment is unknown. Methods: We extracted data from published studies on myeloid engraftment following transplantation of single (9 studies, 1542 engrafted patients) or double (4 studies, 94 en

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15

Akhmedov, M. I., G. A. Klyasova, E. N. Parovichnikova, et al. "Bloodstream infections in different stage of reconstitution after first allogeneic hematopoietic stem cell transplantation." Oncohematology 17, no. 1 (2022): 121–34. http://dx.doi.org/10.17650/1818-8346-2022-17-1-121-134.

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Background. Bloodstream infections (BSI) are common after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The objective of study was to analyze pre- and post-engraftment BSI.Materials and methods. From January 2018 till May 2021242 patients after first allo-HSCT were enrolled in the study. Median age was 35 (17–65) years. The majority of transplants were done for acute leukemias (71.9 %) in remission (91.7 %) with reduced-intensity conditioning regimens (71.5 %) and peripheral blood stem cells (74.4 %) as a graft source.Results. Of 242 patients 95 (39.2 %) developed BSI: 79 (83

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16

Singla, Nirmish, Layton Woolford, Christina Stevens, et al. "Leveraging a robust patient-derived xenograft platform to characterize predictors for engraftment and oncologic outcomes in renal cell carcinoma patients." Journal of Clinical Oncology 37, no. 7_suppl (2019): 651. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.651.

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651 Background: Patient-derived xenograft (PDX) models of renal cell carcinoma (RCC) preserve the biological features of patient tumors, providing a platform for biomarker identification and preclinical drug testing. We sought to identify predictors of successful tumor engraftment and evaluate the prognostic value of engraftment in patients with RCC using a robust murine PDX platform. Methods: 1,200 specimens derived from nephrectomy, thrombectomy, metastasectomy, or biopsy were orthotopically (renally) implanted into NOD/SCID mice between 2008-2018. Non-RCC pathology was excluded. Stable engr

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17

Iwama, Kanichi, Jun Aoki, Noriyuki Tadera, et al. "Moving Average Of Immature Platelet Fraction Predict Late Platelet Engraftment After Reduced-Intensity Cord Blood Transplantation: A Single-Institutional Study." Blood 122, no. 21 (2013): 4583. http://dx.doi.org/10.1182/blood.v122.21.4583.4583.

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Introduction Platelet engraftment is an important marker of successful allogeneic stem cell transplantation and platelet is the last to be regenerated in bone marrow after stem cell transplantation. Especially, platelet engraftment is far slower in reduced-intensity conditioning regimen(RIC) in cord blood transplant(CBT). Early prediction of platelet engraftment in RIC-CBT can be helpful to proper treatment. Recent retrospective studies suggested immature platelet fraction(IPF) can be useful to predict platelet engraftment. However, the role of IPF in RIC-CBT is not be sufficiently investigate

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18

Kampf, C., and P.-O. Carlsson. "Physiology of Islet Engraftment." Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry 6, no. 2 (2006): 167–78. http://dx.doi.org/10.2174/187152206776359902.

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19

Du Toit, Andrea. "Principles of microbiota engraftment." Nature Reviews Microbiology 16, no. 4 (2018): 186. http://dx.doi.org/10.1038/nrmicro.2018.29.

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20

QUESENBERRY, P. J., F. M. STEWART, P. BECKER, et al. "Stem Cell Engraftment Strategies." Annals of the New York Academy of Sciences 938, no. 1 (2006): 54–62. http://dx.doi.org/10.1111/j.1749-6632.2001.tb03574.x.

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21

Nilsson, Susan K., Paul J. Simmons, and Ivan Bertoncello. "Hemopoietic stem cell engraftment." Experimental Hematology 34, no. 2 (2006): 123–29. http://dx.doi.org/10.1016/j.exphem.2005.08.006.

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22

Appelbaum, Frederick R., and Jerald P. Radich. "CHIPs and engraftment dips." Blood 130, no. 1 (2017): 7–9. http://dx.doi.org/10.1182/blood-2017-05-782664.

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23

Johansson, Magnus, Leif Jansson, and Per-Ola Carlsson. "Autotransplantation improves islet engraftment." Transplantation 76, Supplement (2003): S32. http://dx.doi.org/10.1097/00007890-200308271-00042.

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24

Williams, Elizabeth J. "Engraftment and Outcomes Analysis." Biology of Blood and Marrow Transplantation 22, no. 3 (2016): S437. http://dx.doi.org/10.1016/j.bbmt.2015.11.996.

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Williams, Elizabeth J., and Michelle Hudspeth. "Engraftment and Outcomes Analysis." Biology of Blood and Marrow Transplantation 23, no. 3 (2017): S422—S423. http://dx.doi.org/10.1016/j.bbmt.2016.12.513.

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Fomin, Marina E., Ashley I. Beyer, Jean Publicover, et al. "Higher Serum Alanine Transaminase Levels in Male Urokinase-Type Plasminogen Activator-Transgenic Mice are Associated with Improved Engraftment of Hepatocytes but not Liver Sinusoidal Endothelial Cells." Cell Medicine 9, no. 3 (2017): 117–25. http://dx.doi.org/10.3727/215517916x693375.

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The effects of sex on the degree of liver damage and human cell engraftment were investigated in immunodeficient urokinase-type plasminogen activator-transgenic (uPA-NOG) mice. Liver damage, measured by serum alanine transaminase (ALT) levels, was compared in male and female uPA-NOG mice of different ages. Male mice had significantly higher ALT levels than females with a median of 334 versus 158 U/L in transgenic homozygous mice, respectively. Mice were transplanted with human adult hepatocytes or fetal liver cells and analyzed for any correlation of engraftment of hepatocytes, liver sinusoida

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27

Masson, Emeline, François Kleinclauss, Sylvain Perruche, et al. "Effects of Immunosuppressive Drugs on Hematopoietic Engraftment after Simultaneous Infusion of Apoptotic Cells and Bone Marrow Cells." Blood 106, no. 11 (2005): 5207. http://dx.doi.org/10.1182/blood.v106.11.5207.5207.

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Abstract We have recently showed in a murine bone marrow transplantation (BMT) model that apoptotic cell infusion simultaneously with a bone marrow (BM) graft favors hematopoietic engraftment, and induces a long term tolerance restricted to BM cell allo-antigens. This effect is observed whatever the origin of apoptotic cells and does not lead to the development of autoimmunity or GvHD. This favorable effect on engraftment was obtained without immunosuppressive (IS) drugs. In human BMT, IS treatment is always required. The aim of this study was to investigate the interactions between apoptotic

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Suwabe, Tatsuya, Kyoko Fuse, Takayuki Katagiri, et al. "Clinical Features and Risk Factors of Post-Engraftment Bloodstream Infection in Allogeneic HCT." Blood 132, Supplement 1 (2018): 5712. http://dx.doi.org/10.1182/blood-2018-99-115844.

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Abstract [Introduction] Bloodstream infection (BSI) is a serious complication of HCT that may be life-threatening. BSI frequently occurs before neutrophil engraftment (pre-engraftment BSI), but has also been reported after neutrophil recovery (post-engraftment BSI). In contrast to pre-engraftment BSI, the clinical features and risk factors of post-engraftment BSI remain unclear. [Aims] We investigated the clinical characteristics of and risk factors for post-engraftment BSI. [Methods] This retrospective study included 176 adult patients who underwent HCT and achieved neutrophil engraftment bet

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Sadelain, M. W., M. Voralia, D. R. Green, and T. G. Wegmann. "The role of natural suppressor and natural killer activities in resistance to hemopoietic transplantation in unirradiated hosts." Journal of Immunology 142, no. 7 (1989): 2270–78. http://dx.doi.org/10.4049/jimmunol.142.7.2270.

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Abstract We report here that bone marrow stem cell engraftment in unirradiated hosts correlates with levels of natural suppressor (NS) activity in the host at the time of transplantation. This is shown in the antibody-facilitated murine chimeras, in which conditioning consists of a single injection of anti-host MHC antibody, which results in long term hemopoietic engraftment in P----F1 and syngeneic donor-host combinations. The data establish that, in two independent situations, engraftment is reduced in hosts with elevated NS activity. Resistance to engraftment in antibody-conditioned adult h

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30

Lewis, Ian D., Louise A. McDiarmid, Leanne M. Samels, L. Bik To, and Timothy P. Hughes. "Establishment of a Reproducible Model of Chronic-Phase Chronic Myeloid Leukemia in NOD/SCID Mice Using Blood-Derived Mononuclear or CD34+ Cells." Blood 91, no. 2 (1998): 630–40. http://dx.doi.org/10.1182/blood.v91.2.630.

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Abstract An animal model of chronic myeloid leukemia (CML) will help characterize leukemic and normal stem cells and also help evaluate experimental therapies in this disease. We have established a model of CML in the NOD/SCID mouse. Infusion of ≥4 × 107chronic-phase CML peripheral blood cells results in engraftment levels of ≥1% in the bone marrow (BM) of 84% of mice. Engraftment of the spleen was seen in 60% of mice with BM engraftment. Intraperitoneal injection of recombinant stem cell factor produced a higher level of leukemic engraftment without increasing Philadelphia-negative engraftmen

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Lewis, Ian D., Louise A. McDiarmid, Leanne M. Samels, L. Bik To, and Timothy P. Hughes. "Establishment of a Reproducible Model of Chronic-Phase Chronic Myeloid Leukemia in NOD/SCID Mice Using Blood-Derived Mononuclear or CD34+ Cells." Blood 91, no. 2 (1998): 630–40. http://dx.doi.org/10.1182/blood.v91.2.630.630_630_640.

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An animal model of chronic myeloid leukemia (CML) will help characterize leukemic and normal stem cells and also help evaluate experimental therapies in this disease. We have established a model of CML in the NOD/SCID mouse. Infusion of ≥4 × 107chronic-phase CML peripheral blood cells results in engraftment levels of ≥1% in the bone marrow (BM) of 84% of mice. Engraftment of the spleen was seen in 60% of mice with BM engraftment. Intraperitoneal injection of recombinant stem cell factor produced a higher level of leukemic engraftment without increasing Philadelphia-negative engraftment. Granul

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Martins-Filho, Sebastiao N., Jessica Weiss, Nhu-An Pham, et al. "Clinical, pathological and genetic predictors of patient-derived xenograft (PDX) engraftment in EGFR-mutated lung adenocarcinoma (LUAD)." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3110. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3110.

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3110 Background: PDX are useful preclinical models to study drug response and resistance. Different specimen types have been used to generate PDX models including histological (surgery and CT-guided biopsy) and cytological preparations (EBUS and pleural effusions). We hypothesize that engraftment is not stochastic and is affected by many factors including sample type and tumor pathological and molecular properties. To improve sample selection and cost-effectiveness of PDX experiments, we investigated clinical, histological and genetic correlates of engraftment in EGFR-mutated LUAD. Methods: We

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Singla, Nirmish, Layton Woolford, Christina Stevens, et al. "Leveraging a robust patient-derived xenograft platform to characterize predictors for engraftment and oncologic outcomes in renal cell carcinoma patients." Journal of Clinical Oncology 37, no. 15_suppl (2019): e16100-e16100. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e16100.

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e16100 Background: Patient-derived xenograft (PDX) models of renal cell carcinoma (RCC) preserve the biological features of patient tumors, providing a platform for biomarker identification and preclinical drug testing. We sought to identify predictors of successful tumor engraftment and evaluate the prognostic value of engraftment in patients with RCC using a robust murine PDX platform. Methods: 1,200 specimens derived from nephrectomy, thrombectomy, metastasectomy, or biopsy were orthotopically (renally) implanted into NOD/SCID mice between 2008-2018. Non-RCC pathology was excluded. Stable e

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Habibian, Houri K., Stefan O. Peters, C. C. Hsieh, et al. "The Fluctuating Phenotype of the Lymphohematopoietic Stem Cell with Cell Cycle Transit." Journal of Experimental Medicine 188, no. 2 (1998): 393–98. http://dx.doi.org/10.1084/jem.188.2.393.

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The most primitive engrafting hematopoietic stem cell has been assumed to have a fixed phenotype, with changes in engraftment and renewal potential occurring in a stepwise irreversible fashion linked with differentiation. Recent work shows that in vitro cytokine stimulation of murine marrow cells induces cell cycle transit of primitive stem cells, taking 40 h for progression from G0 to mitosis and 12 h for subsequent doublings. At 48 h of culture, progenitors are expanded, but stem cell engraftment is markedly diminished. We have investigated whether this effect on engraftment was an irreversi

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Avery, Sharon, Weiji Shi, Marissa Lubin, et al. "Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts." Blood 117, no. 12 (2011): 3277–85. http://dx.doi.org/10.1182/blood-2010-08-300491.

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Abstract The influence of cell dose and human leukocyte antigen (HLA) match on double-unit cord blood (CB) engraftment is not established. Therefore, we analyzed the impact of cell dose and high-resolution HLA match on neutrophil engraftment in 84 double-unit CB transplant recipients. The 94% sustained engraftment rate was accounted for by 1 unit in nearly all patients. Higher CD3+ cell doses (P = .04) and percentage of CD34+ cell viability (P = .008) were associated with unit dominance. After myeloablative conditioning, higher dominant unit total nucleated cell (TNC), CD34+ cell, and colony-f

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Tauer, Jeff, Leonard Shultz, Tessa Holyoake, and Ravi Bhatia. "Normal Short-Term but Reduced Long-Term Engraftment Capacity of CML Hematopoietic Cells with Skewed Myeloid Lineage Differentiation Is Seen in an Improved Mouse Model of Human Hematopoiesis." Blood 110, no. 11 (2007): 3383. http://dx.doi.org/10.1182/blood.v110.11.3383.3383.

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Abstract The NOD/SCID mouse model has been widely used to assay human hematopoietic cells capable of long-term multilineage engraftment (SCID-repopulating cells or SRC). Leukemia cells from CML patients can also engraft in NOD-SCID mice. However the utility of this model for studying CML stem cells is limited by inconsistent and low levels of engraftment, and lack of a leukemia-related phenotype of engrafted cells. Since NOD/SCID IL2Rγchain KO (NOG) mice support superior engraftment of human hematopoietic cells compared with NOD/SCID mice, they may allow for improved evaluation of CML stem cel

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Robinson, Simon N., Hong Yang, William K. Decker, et al. "Fucosylation of Cord Blood CD34+ Cells Improves the Rate of Engraftment without Compromising Long-Term Engraftment." Blood 110, no. 11 (2007): 1187. http://dx.doi.org/10.1182/blood.v110.11.1187.1187.

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Abstract INTRODUCTION: Delayed engraftment following cord blood (CB) transplantation remains a major challenge. While cell dose is clearly limiting, CB-derived hematopoietic stem cells (HSC) also appear to have a deficit in homing and engraftment. CB HSC have low levels of surface fucosylation. Increasing the level of surface fucosylation might improve interactions with selectins expressed by the microvasculature of the hematopoietic microenvironment, potentially improving homing and engraftment. METHODS: Human CB CD34+ were fucosylated using a recombinant fucosyltransferase (FTVI, Engraftin™,

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Rafiee, Mohammad, Hossein Bonakchi, Pordanjani Sajjad Rahimi, et al. "Enhancing CD34+ Cell Mobilization and Engraftment after Autologous Hematopoietic Stem Cell Transplantation via Adjustment of Granulocyte Colony-Stimulating Factor Dose and Period, a Single Center Experience." Journal of Advances in Medical and Biomedical Research 131, no. 148 (2023): 488–98. https://doi.org/10.30699/jambs.31.148.488.

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<strong>Abstract</strong> <strong>Background and Objective: </strong>Insufficient mobilization of hematopoietic stem cells and delayed engraftment are reported in autologous hematopoietic stem cell transplantation (AHSCT). The aim if this study was to identify and introduce predictive factors for mobilization and engraftment.<strong>Materials and Methods: </strong>The participants include AHSCT candidates. Pre-apheresis CD34<sup>+</sup> cells and CD34<sup>+</sup> count per kilogram (CD34<sup>+</sup> CPK) in the apheresis products were assessed by flow cytomet

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Wang, Xiuli, Michael Rosol, Shundi Ge, et al. "Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging." Blood 102, no. 10 (2003): 3478–82. http://dx.doi.org/10.1182/blood-2003-05-1432.

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Abstract The standard approach to assess hematopoietic stem cell (HSC) engraftment in experimental bone marrow transplantation models relies on detection of donor hematopoietic cells in host bone marrow following death; this approach provides data from only a single time point after transplantation for each animal. In vivo bioluminescence imaging was therefore explored as a method to gain a dynamic, longitudinal profile of human HSC engraftment in a living xenogeneic model. Luciferase expression using a lentiviral vector allowed detection of distinctly different patterns of engraftment kinetic

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Durkin, Emily T., Kelly A. Jones, Deepika Rajesh, and Aimen F. Shaaban. "Early chimerism threshold predicts sustained engraftment and NK-cell tolerance in prenatal allogeneic chimeras." Blood 112, no. 13 (2008): 5245–53. http://dx.doi.org/10.1182/blood-2007-12-128116.

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Abstract The failure of engraftment in human cases of in utero hematopoietic cell transplantation (IUHCT) in which no immunodeficiency exists suggests the presence of an unrecognized fetal immune barrier. A similar barrier in murine IUHCT appears to be dependent on the chimerism level and is poorly explained by a lack of T-cell tolerance induction. Therefore, we studied the effect of the chimerism level on engraftment and host natural killer (NK)–cell education in a murine model of IUHCT. The dose of transplanted cells was found to exhibit a strong correlation with both the engraftment rate an

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Cao, Thai M., Alun Thomas, Yuanyuan Wang, Schickwann Tsai, Kathryn Logronio, and Judith A. Shizuru. "A chromosome 16 quantitative trait locus regulates allogeneic bone marrow engraftment in nonmyeloablated mice." Blood 114, no. 1 (2009): 202–10. http://dx.doi.org/10.1182/blood-2009-03-208801.

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Abstract Identifying genes that regulate bone marrow (BM) engraftment may reveal molecular targets for overcoming engraftment barriers. To achieve this aim, we applied a forward genetic approach in a mouse model of nonmyeloablative BM transplantation. We evaluated engraftment of allogeneic and syngeneic BM in BALB.K and B10.BR recipients. This allowed us to partition engraftment resistance into its intermediate phenotypes, which are firstly the immune-mediated resistance and secondly the nonimmune rejection of donor BM cells. We observed that BALB.K and B10.BR mice differed with regard to each

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Shimomura, Yoshimitsu, Yuichiro Ono, Satoshi Yoshioka, et al. "Splenomegaly Negatively Affects Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome after Allogeneic Stem Cell Transplantation." Blood 128, no. 22 (2016): 2198. http://dx.doi.org/10.1182/blood.v128.22.2198.2198.

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Abstract Introduction: Primary graft failure or delayed engraftment is a well-studied complication of allogeneic hematopoietic stem cell transplantation (HSCT). According to previous studies, the following factors are associated with primary graft failure or delayed engraftment: underlying disease, disease status, human leukocyte antigen (HLA) disparity between recipient and donor, type of conditioning regimens, stem cell source, and stem cell dose. As engraftment failure or delayed engraftment frequently brings uncontrollable infectious events for allogeneic HSCT recipients, the prevention of

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Pixley, John S., Jessica L. Skopal-Chase, Alireza Torabi, et al. "Immune Ontogeny and Engraftment Receptivity in the Sheep Fetus." Blood 112, no. 11 (2008): 3493. http://dx.doi.org/10.1182/blood.v112.11.3493.3493.

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Abstract The therapeutic application of in utero hematopoietic stem cell (HSC) transplantation (IUHSCT) is theoretically attractive for definitive treatment of congenital disease states. Investigating this technique in sheep, we have previously shown long-term engraftment and expression of both allogeneic and xenogeneic donor cells without cytoablation and, under appropriate conditions, without GVHD. The theoretical basis for IUHSCT is the well-recognized immune receptivity of the fetus to engraftment of donor cells. Engraftment and long-term expression of donor human and allogeneic sheep HSC

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De Luna, Gonzalo, Nicolas Hebert, Ivan Sloma, et al. "Erythroid-Specific Chimerism Analysis after Allogeneic-Hematopoietic Stem Cell Transplantation Using a Human Leukocyte Antigen-Identical Sibling Donor in Sickle Cell Disease Patients." Blood 144, Supplement 1 (2024): 4875. https://doi.org/10.1182/blood-2024-209526.

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Introduction: Allogeneic-hematopoietic stem cell transplantation (HSCT) using a human leukocyte antigen (HLA)-identical sibling donor is a proven cure for Sickle Cell disease (SCD). At least 20% donor myeloid chimerism in peripheral blood (PB) may be sufficient to reverse the sickle phenotype after HSCT. Here, we sought to implement an erythroid-specific chimerism analysis in order to decipher kinetics of lineage-specific engraftments and correlated biological and clinical phenotypes. Method: Adult SCD patients who underwent an allogeneic non-myeloablative HSCT from HLA-matched related donors

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Hartz, Bernd, Thorsten Volkmann, Sebastian Irle, Cordula Loechelt, Andreas Neubauer та Cornelia Brendel. "α4 integrin levels on mobilized peripheral blood stem cells predict rapidity of engraftment in patients receiving autologous stem cell transplantation". Blood 118, № 8 (2011): 2362–65. http://dx.doi.org/10.1182/blood-2011-02-331918.

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Abstract Rapidness of leukocyte engraftment in patients receiving peripheral blood stem cell transplantation is clinically important because the risk of fatal opportunistic infections increases with time to engraftment. Adhesion receptor molecules on hematopoietic stem cells (HSCs) have been shown to modulate homing and engraftment of HSCs. Therefore, we correlated expression levels of α4 (CD49d) and α6 (CD49f) integrins in the CD34+ HSC compartment with time to engraftment. Leukapheresis products from 103 patients were retrospectively analyzed for CD34, CD38, CD3, CD49f, and CD49d surface mol

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Ellegast, Jana M., Yasuyuki Saito, Richard A. Flavell та Markus G. Manz. "ΜΙSΤRG Mice Support Good-Risk AML Engraftment". Blood 124, № 21 (2014): 3808. http://dx.doi.org/10.1182/blood.v124.21.3808.3808.

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Abstract Introduction Acute myeloid leukemia (AML) is a hematopoietic stem cell derived disease with still unsatisfactory treatment options. Its broad biological heterogeneity needs to be dissected by deeper mechanistic understanding to translate functional insights into novel therapeutic strategies. AML engraftment in murine models and subsequent in vivo studies have been limited to clinically aggressive AML and cell lines. In fact there is no published xenograft model for good risk AML. The hypothesis of a humanized environment being favorable for AML engraftment motivates the development of

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Wen, Sicheng, Laura R. Goldberg, Mark S. Dooner, et al. "Long-Term Effect of Mesenchymal Stromal Cell Derived Extracellular Vesicles on the Restoration of Engraftment of Stem Cells in Radiation Exposed Mice." Blood 132, Supplement 1 (2018): 5102. http://dx.doi.org/10.1182/blood-2018-99-118950.

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Abstract Extracellular vesicles (EVs) including exosomes and microvesicles, have been found to deliver both mRNA and transcriptional modulators to target cells and affect their phenotype. Vesicles derived from mesenchymal stem cells (MSC) have been shown to affect the phenotype and induce healing of many different cell types. Our recent published work has shown that pretreated irradiated murine bone marrow stem cells with human or murine MSC-EV in vitro, could significantly improve the engraftment capacity of radiation-damaged stem cells up to 9 months post-transplantation. Interestingly, the

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Davies, Stella M., Craig Kollman, Claudio Anasetti, et al. "Engraftment and survival after unrelated-donor bone marrow transplantation: a report from the National Marrow Donor Program." Blood 96, no. 13 (2000): 4096–102. http://dx.doi.org/10.1182/blood.v96.13.4096.

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Abstract We analyzed engraftment of unrelated-donor (URD) bone marrow in 5246 patients who received transplants facilitated by the National Marrow Donor Program between August 1991 and June 1999. Among patients surviving at least 28 days, 4% had primary graft failure (failure to achieve an absolute neutrophil count &gt; 5 × 108/L before death or second stem-cell infusion). Multivariate logistic regression analysis showed that engraftment was associated with marrow matched at HLA-A, HLA-B, and DRB1; higher cell dose; younger recipient; male recipient; and recipient from a non–African Americ

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Davies, Stella M., Craig Kollman, Claudio Anasetti, et al. "Engraftment and survival after unrelated-donor bone marrow transplantation: a report from the National Marrow Donor Program." Blood 96, no. 13 (2000): 4096–102. http://dx.doi.org/10.1182/blood.v96.13.4096.h8004096_4096_4102.

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We analyzed engraftment of unrelated-donor (URD) bone marrow in 5246 patients who received transplants facilitated by the National Marrow Donor Program between August 1991 and June 1999. Among patients surviving at least 28 days, 4% had primary graft failure (failure to achieve an absolute neutrophil count > 5 × 108/L before death or second stem-cell infusion). Multivariate logistic regression analysis showed that engraftment was associated with marrow matched at HLA-A, HLA-B, and DRB1; higher cell dose; younger recipient; male recipient; and recipient from a non–African American ethnic gro

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Hamaki, Tamae, Koichi Kajiwara, Keiko Hoshi, et al. "Reduced Intensity Cord Blood Transplantation Using Mycophenolate Mofetil and Cyclosporine for Adult Patients with Advanced Hematologic Malignancies." Blood 106, no. 11 (2005): 2889. http://dx.doi.org/10.1182/blood.v106.11.2889.2889.

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Abstract Objectives: To evaluate the feasibility of reduced-intensity unrelated cord-blood transplantation (RI-UCBT) using cyclosporine and mycofenolate mofetil as graft-versus-host disease (GVHD) prophylaxis for adult patients with advanced hematological diseases Methods: Twenty-one patients (median age, 54; range, 30–76) with advanced hematological diseases underwent RI-UCBT at Metropolitan Fuchu Hospital between July 2002 and September 2004. Underlying disease included AML (n=7), non-Hodgkin lymphoma (n=10), Hodgkin lymphoma (n=2), and aplastic anemia (n=1). Preparative regimen comprised fl

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