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Dissertations / Theses on the topic 'Fatty acyl desaturase 2'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Zhang, Daiyuan. "Expression analysis of the fatty acid desaturase 2-4 and 2-3 genes from Gossypium hirsutum in transformed yeast cells and transgenic Arabidopsis plants." Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc9002/.

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Fatty acid desaturase 2 (FAD2) enzymes are phosphatidylcholine desaturases occurring as integral membrane proteins in the endoplasmic reticulum membrane and convert monounsaturated oleic acid into polyunsaturated linoleic acid. The major objective of this research was to study the expression and function of two cotton FAD2 genes (the FAD2-3 and FAD2-4 genes) and their possible role in plant sensitivity to environmental stress, since plants may increase the polyunsaturated phospholipids in membranes under environmental stress events, such as low temperature and osmotic stress. Two FAD2 cDNA

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2

Zhang, Daiyuan Pirtle Robert M. "Expression analysis of the fatty acid desaturase 2-4 and 2-3 genes from Gossypium hirsutum in transformed yeast cells and transgenic Arabidopsis plants." [Denton, Tex.] : University of North Texas, 2008. http://digital.library.unt.edu/permalink/meta-dc-9002.

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3

Huo, Tianyao. "Impact of fatty acyl composition and quantity of triglycerides on bioaccessibility of dietary carotenoids." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1195514528.

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4

Xu, Yi. "Development of a Novel Omega-6 Fatty Acid Based Treatment Strategy for Colon Cancer by Knocking Down Delta-5-Desaturase and Exploiting High COX-2 Levels in Cancer CellsTumors." Diss., North Dakota State University, 2017. http://hdl.handle.net/10365/25947.

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Colon cancer is the third most commonly diagnosed cancer in the world. Research showed that arachidonic acid, a downstream ?-6 fatty acid (?-6), plays a role in colon cancer development by producing deleterious metabolites from its COX-2 catalyzed peroxidation. On the other hand, dihomo-?-linolenic acid (DGLA), the immediate precursor of arachidonic acid, may represent an exceptional ?-6 associated with anti-cancer activities. However, the mechanism of DGLA?s anti-cancer effect still remains unclear, and the rapid conversion of DGLA to arachidonic acid in human body by delta-5 desaturase (D5D)

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5

Nampaisansuk, Mongkol. "Molecular cloning and analysis of the genes for cotton palmitoyl-acyl carrier protein thioesterase (PATE) and Δ-12 fatty acid desaturase (FAD2-3) and construction of sense and anti-sense PATE plasmid vectors for altering oilseed composition of transgenic cotton plants". Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3123/.

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A cotton PATE cDNA clone has a 1.7-kb insert with an coding region for 410 amino acids, lacking codons for the three N-terminal amino acids. The predicted amino acid sequence of the PATE preprotein has a characteristic stromal-targeting domain and a 63% identity to the Arabidopsis FatB1 thioesterase sequence. A cotton genomic clone containing a 17.4-kb DNA segment was found to encompass a palmitoyl-ACP thioesterase (FatB1) gene. The gene spans 3.6 kb with six exons and five introns. The six exons are identical in nucleotide sequence to the open reading frame of the corresponding cDNA, and

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6

Revell, Kevin David. "Mode of action and structure-activity studies of N-alkylthio beta-lactams and N-alkylthio-2-oxazolidinones, and synthesis of second-generation disulfide Inhibitors of beta-Ketoacyl-Acyl Carrer Protein Synthase III (FabH) as potent antibacterial agents." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001453.

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7

Jenkins, Benjamin John. "The role of alpha oxidation in lipid metabolism." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/278025.

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Recent findings have shown an inverse association between the circulating levels of pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) with the risk of pathological development in type 2 diabetes, cardio vascular disease and neurological disorders. From previously published research, it has been said that both these odd chain fatty acids are biomarkers of their dietary intake and are significantly correlated to dietary ruminant fat intake. However, there are profound studies that show the contrary where they do not display this biomarker correlation. Additionally, several astute studies

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8

Gianngregorio, Alfredo. "The influence of fatty acids in vitro on mammalian cells from species differing in their fatty acyl desaturase capabilities. Volume. 2." Thesis, 1991. https://hdl.handle.net/10539/24356.

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A Thesis Submitted to the Faculty of Medicine, in Fulfilment of the Requirements for the Degree of • Doctor of Philosophy in the Department of Chemical Pathology, School of Pathology and the South African Institute for Medical Research, University of the Witwatersrand Medical School, Johannesburg, South Africa. December 1991.<br>Numerous studies have assessed the effects of single fatty acids on various aspects of lipid metabolism, particularly cancer. Established cell lines have largely been used for this purpose. The choice of control cells, however, has often been inappropriate. There i

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9

Lyle, Karen S. "Mechanism and function of soluble acyl-acyl carrier protein desaturase systems in fatty acid metabolism." 2003. http://www.library.wisc.edu/databases/connect/dissertations.html.

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10

Hsiao-Chun and 吳曉君. "Cloning of a Zebrafish Fatty Acid Desaturase 2." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/67215759595012103857.

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碩士<br>中山醫學大學<br>營養學研究所<br>95<br>Based on the data mining against NCBI（National Center for Biotechnology Information） data band. The analysis found a fatty acid desaturase-2 (FADS2) of human（NP_004256/NM_00426）and zebrafish（NP_571720.2/NM_131645）. The FADS2 cDNA of zebrafish were successfully amplified with a continuous open reading frame of 1335 bp encoding a protein of 444 amino acid. But the FADS2 cDNA of human were not successfully amplified with a continuous open reading frame of 1335 bp .The FADS2 of human and zebrafish were with a calculated molecular mass of 52.27 and 52.14 kDa . Zebra

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11

Chu, Kuang-Hsi, and 朱光曦. "Molecular Evolution of Fatty acid desaturase 2 in Drosophila." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/14909424382769260953.

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碩士<br>國立臺灣大學<br>動物學研究所<br>96<br>Three fatty acid desaturase genes, namely desat1, desat2 and Fad2, in Drosophila involve in the production of cuticular hydrocarbons (CHs) that serve as sex pheromones. Among them, Fad2 is responsible for female-specific diene pheromone biosynthesis in D. melanogaster and D. sechellia. However, the role of Fad2 in other Drosophila species is still unknown. To address this question, the Fad2 homologs in 12 Drosophila species were analyzed. Based on the sequence information, Fad2 is originated by retrotransposition which took place before the split of Drosophila a

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12

Chu, Kuang-Hsi. "Molecular Evolution of Fatty acid desaturase 2 in Drosophila." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2907200810343000.

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13

Giangregorio, Alfredo. "The influence of fatty acids in vitro on mammalian cells from species differing in their fatty acyl desaturase capabilities." Thesis, 1991. https://hdl.handle.net/10539/25153.

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A Thesis submitted to the Faculty of Medicine, in Fulfilment of the Requirements for the Degree of Doctor of Philosophy<br>Numerous studies have assessed the effects of single fatty acids on various aspects of lipid metabolism, particularly cancer. Established cell lines have largely been used for this purpose. The choice of control cells. however, has often been inappropriate. There is also a surprising lack of knowledge of the effects of fatty acids in the "real world", in which normal cells in vivo are presented with mixtures of dietary fatty acids. Before transformed cells can be

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14

Fubbs, Joanmariae Louise, and Giangregorio Giangregorio. "The influence of fatty acids in vitro on mammalian cells from species differing in their fatty acyl desaturase capabilities." Thesis, 1991. https://hdl.handle.net/10539/24757.

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A Thesis submitted to the Faculty of Medicine, in fulfilment of the Requirements for the Degree of Doctor of Philosophy<br>Numerous studies have assessed the effects of single fatty acids on various aspects of lipid metabolism, particularly cancer. Established cell lines have largely been used for this purpose. The choice of control cells. however, has often been inappropriate. There is also a surprising lack of knowledge of the effects of fatty acids in the "real world", in which normal cells in vivo are presented with mixtures of dietary fatty acids. Before transformed cells can be

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15

Giangregorio, Alfredo. "THE INFLUENCE OF FATTY ACIDS IN VITRO ON MAMMALIAN CELLS FROM SPECIES DIFFERING IN THEIR FATTY ACYL DESATURASE CAPABILITIES.VOL. 1." Thesis, 1991. https://hdl.handle.net/10539/24578.

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A Thesis Submitted to the Faculty of Medicine, in Fulfilment of the Requirements for the Degree of • Doctor of Philosophy<br>Numerous studies have assessed the effects of single fatty acids on various aspects of lipid metabolism, particularly cancer. Established cell lines have largely been used for this purpose. The choice of control cells, however, has often been inappropriate. There is also a surprising lack of knowledge of the effects of fatty acids in the ‘real world", in which normal cells in vivo are presented with mixtures of dietary fatty acids<br>IT2018

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16

Man, Weng Chi. "Topology of stearoyl-CoA desaturase 1 and it's co-localization with acyl-CoA diacylglycerol acyltransferase 2 in endoplasmic reticulum." 2006. http://catalog.hathitrust.org/api/volumes/oclc/84542172.html.

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17

Hoffmann, Mareike. "Ein neuer Syntheseweg für wertvolle Fettsäuren in Saccharomyces cerevisiae und Arabidopsis thaliana." Doctoral thesis, 2009. http://hdl.handle.net/11858/00-1735-0000-0006-AD55-C.

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18

Scharnewski, Michael. "Untersuchungen zum Fettsäuretransport durch zelluläre und peroxisomale Membranen." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-ADCD-2.

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19

Bates, Philip David. "Re-examining the initial steps of membrane and storage lipid assembly in pea leaves and soybean embryos the dominant flux of newly synthesized fatty acid incorporation into extra-plastidic glycerolipids is through phosphatidylcholine acyl editing /." Diss., 2008. http://proquest.umi.com/pqdweb?did=1681946151&sid=1&Fmt=2&clientId=3552&RQT=309&VName=PQD.

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Thesis (Ph. D.)--Michigan State University. Biochemistry and Molecular Biology, 2008.<br>Title from PDF t.p. (Proquest, viewed on Aug. 17, 2009) Includes bibliographical references (p. 187-203). Also issued in print.

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20

Lamantia, Valérie. "Effet des acides gras oméga-3 sur l’inflammasome NLRP3 et les facteurs de risque de diabète de type 2 chez l’humain : modèles in vivo et ex vivo." Thesis, 2019. http://hdl.handle.net/1866/24589.

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Contexte : La dysfonction du tissu adipeux blanc (TAB) favorise les facteurs de risque de diabète de type 2 (DbT2), c’est-à-dire la résistance à l’insuline (RI), l’hyper sécrétion d’insuline glucostimulée (SIGS), le délai de clairance des gras et les concentrations élevées d’apoBlipoprotéines (apoB plasmatique) incluant les lipoprotéines de faible densité (LDL). De récentes études de notre laboratoire et d’autres suggèrent que le niveau élevé d’apoB plasmatique (hyperapoB) est une cause et non seulement une conséquence de la dysfonction du TAB. De plus, une internalisation augmentée d’apoB-li

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21

Pepin, Émilie. "Étude dans la cellule bêta pancréatique de voies inhibitrices de la sécrétion d'insuline liées au métabolisme des lipides." Thèse, 2013. http://hdl.handle.net/1866/9717.

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Le diabète de type 2 (DT2) est une maladie métabolique complexe causée par des facteurs génétiques mais aussi environnementaux, tels la sédentarité et le surpoids. La dysfonction de la cellule β pancréatique est maintenant reconnue comme l’élément déterminant dans le développement du DT2. Notre laboratoire s’intéresse à la sécrétion d’insuline par la cellule β en réponse aux nutriments calorigéniques et aux mécanismes qui la contrôle. Alors que la connaissance des mécanismes responsables de l’induction de la sécrétion d’insuline en réponse aux glucose et acides gras est assez avancée, les proc

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22

Murphy, Caitlin. "The Visual Impairment/Cognitive Impairment Co-morbidity : Examining the Genotype-Structure-Function Relationship." Thèse, 2017. http://hdl.handle.net/1866/19986.

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