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Journal articles on the topic 'Fatty acyl desaturase 2'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

Chintalapati, Suresh, Jogadhenu Shyam Sunder Prakash, Pratima Gupta та ін. "A novel Δ9 acyl-lipid desaturase, DesC2, from cyanobacteria acts on fatty acids esterified to the sn−2 position of glycerolipids". Biochemical Journal 398, № 2 (2006): 207–14. http://dx.doi.org/10.1042/bj20060039.

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Acyl-lipid desaturases are enzymes that convert a C–C single bond into a C=C double bond in fatty acids that are esterified to membrane-bound glycerolipids. Four types of acyl-lipid desaturase, namely DesA, DesB, DesC, and DesD, acting at the Δ12, Δ15, Δ9, and Δ6 positions of fatty acids respectively, have been characterized in cyanobacteria. These enzymes are specific for fatty acids bound to the sn−1 position of glycerolipids. In the present study, we have cloned two putative genes for a Δ9 desaturase, designated desC1 and desC2, from Nostoc species. The desC1 gene is highly similar to the d

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Tavares, Sabina, Thomas Grotkjær, Thomas Obsen, Richard P. Haslam, Johnathan A. Napier та Nina Gunnarsson. "Metabolic Engineering ofSaccharomyces cerevisiaefor Production of Eicosapentaenoic Acid, Using a Novel Δ5-Desaturase fromParamecium tetraurelia". Applied and Environmental Microbiology 77, № 5 (2010): 1854–61. http://dx.doi.org/10.1128/aem.01935-10.

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ABSTRACTVery-long-chain polyunsaturated fatty acids, such as arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have well-documented importance in human health and nutrition. Sustainable production in robust host organisms that do not synthesize them naturally requires the coordinated expression of several heterologous desaturases and elongases. In the present study we show production of EPA inSaccharomyces cerevisiaeusing glucose as the sole carbon source through expression of five heterologous fatty acid desaturases and an elongase. Novel Δ5-desaturases from

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3

Ding, Bao-Jian, Yi-Han Xia, Hong-Lei Wang, et al. "Biosynthesis of the Sex Pheromone Component (E,Z)-7,9-Dodecadienyl Acetate in the European Grapevine Moth, Lobesia botrana, Involving ∆11 Desaturation and an Elusive ∆7 Desaturase." Journal of Chemical Ecology 47, no. 3 (2021): 248–64. http://dx.doi.org/10.1007/s10886-021-01252-3.

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AbstractThe European grapevine moth, Lobesia botrana, uses (E,Z)-7,9-dodecadienyl acetate as its major sex pheromone component. Through in vivo labeling experiments we demonstrated that the doubly unsaturated pheromone component is produced by ∆11 desaturation of tetradecanoic acid, followed by chain shortening of (Z)-11-tetradecenoic acid to (Z)-9-dodecenoic acid, and subsequently introduction of the second double bond by an unknown ∆7 desaturase, before final reduction and acetylation. By sequencing and analyzing the transcriptome of female pheromone glands of L. botrana, we obtained 41 cand

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Zäuner, Simone, Wibke Jochum, Tara Bigorowski, and Christoph Benning. "A Cytochrome b 5 -Containing Plastid-Located Fatty Acid Desaturase from Chlamydomonas reinhardtii." Eukaryotic Cell 11, no. 7 (2012): 856–63. http://dx.doi.org/10.1128/ec.00079-12.

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ABSTRACT Monogalactosyldiacylglycerol (MGDG) in Chlamydomonas reinhardtii and other green algae contains hexadeca-4,7,10,13-tetraenoic acid (16:4) in the glycerol sn- 2 position. While many genes necessary for the introduction of acyl chain double bonds have been functionally characterized, the Δ4-desaturase remained unknown. Using a phylogenetic comparison, a candidate gene encoding the MGDG-specific Δ4-desaturase from Chlamydomonas (CrΔ4FAD) was identified. CrΔ4FAD shows all characteristic features of a membrane-bound desaturase, including three histidine boxes and a transit peptide for chlo

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NAKASHIMA, Shigeru, Yutong ZHAO та Yoshinori NOZAWA. "Molecular cloning of Δ9 fatty acid desaturase from the protozoan Tetrahymena thermophila and its mRNA expression during thermal membrane adaptation". Biochemical Journal 317, № 1 (1996): 29–34. http://dx.doi.org/10.1042/bj3170029.

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In response to a decrease in its growth temperature, the protozoan Tetrahymena is known to increase the level of unsaturated fatty acids in its membrane phospholipids so as to maintain the correct physical state (fluidity) of the membranes. In this organism, synthesis of unsaturated fatty acids is initiated by Δ9 acyl-CoA desaturase. Our previous studies have shown that, during cold adaptation, the activity of microsomal palmitoyl- and stearoyl-CoA desaturase increases, reaching a maximal level at 2 h after a temperature down-shift to 15 °C. Two hypotheses have been proposed to explain this in

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Griffiths, G., A. K. Stobart та S. Stymne. "Δ 6- and Δ12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis)". Biochemical Journal 252, № 3 (1988): 641–47. http://dx.doi.org/10.1042/bj2520641.

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Microsomal membrane preparations from the maturing cotyledons of common borage (Borago officinalis) exhibit delta 12- and delta 6-desaturase activities, which resulted in the synthesis of linoleate and gamma-linolenate respectively. The desaturase enzymes utilized the complex lipid substrate phosphatidylcholine. The activity of these enzymes was sufficiently high to allow the monitoring of the mass changes in the endogenous oleate, linoleate and gamma-linolenate in the microsomal phosphatidylcholine in the presence of NADH (i.e. under desaturating conditions). The results illustrate that the d

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Chen, Xiao, Yi-Can Zhang, Si-Yu Zhang, Yi-Qian Zhou, and Na Cui. "Prediction of Omega-3 Fatty Acid Desaturase in Tomato." Biotechnology Journal International 29, no. 4 (2025): 14–24. https://doi.org/10.9734/bji/2025/v29i4782.

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Aims: The jasmonic acid (JA) pathway plays a core role in the plant defense response, and the omega-3 fatty acid desaturase (FAD7 protein) is closely related to the synthesis and signal transduction of JA by regulating fatty acid metabolism. However, the regulation differences of FAD7 in different plants and the correlation between the regulation of fatty acid metabolism and the dynamic balance of JA signaling remain unclear. Therefore, it has great significance to clarify the properties, structure and protein interaction network of the FAD7 protein for the study of the plant defense response

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8

Schmidt, H., and E. Heinz. "Direct desaturation of intact galactolipids by a desaturase solubilized from spinach (Spinacia oleracea) chloroplast envelopes." Biochemical Journal 289, no. 3 (1993): 777–82. http://dx.doi.org/10.1042/bj2890777.

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In plants, polyenoic fatty acids are synthesized by desaturase enzymes which use acyl groups of membrane lipids as substrates. To provide direct ‘in vitro’ evidence for this reaction, we solubilized envelope membranes from spinach (Spinacia oleracea) chloroplasts with Triton X-100 to release a membrane-bound n-6 desaturase. In the presence of oxygen and reduced ferredoxin, the solubilized enzyme desaturated a variety of substrates, such as free oleic acid, free erucic acid, 1-oleoyl-sn-glycerol 3-phosphate and the three galactolipids 1-oleoyl-2-(7′-cis-hexadecenoyl)-3-beta-D-galactopyranosyl-s

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9

Tian, Jieyun, Lu Tian, Ming Chen, Yabing Chen, and Anzhi Wei. "Low Temperature Affects Fatty Acids Profiling and Key Synthesis Genes Expression Patterns in Zanthoxylum bungeanum Maxim." International Journal of Molecular Sciences 23, no. 4 (2022): 2319. http://dx.doi.org/10.3390/ijms23042319.

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Zanthoxylum bungeanum is one of the most important medicinal and edible homologous plants because of its potential health benefits and unique flavors. The chemical components in compositions and contents vary with plant genotype variations and various environmental stress conditions. Fatty acids participate in various important metabolic pathways in organisms to resist biotic and abiotic stresses. To determine the variations in metabolic profiling and genotypes, the fatty acid profiling and key differential genes under low temperature stress in two Z. bungeanum varieties, cold-tolerant (FG) an

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Hu, Wei, Junyi Ma, Hongjie Zhang, Xin Miu, Xin Miao, and Yu Deng. "Integrated lipidomic and transcriptomic analysis reveals diacylglycerol accumulation in olive of Longnan (China)." PeerJ 11 (August 11, 2023): e15724. http://dx.doi.org/10.7717/peerj.15724.

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Background Olive (Olea europaea L.) oil accumulate more diacylglycerols (DAG) than mostly vegetable oils. Unsaturated fatty acids-enriched DAG consumption enhanced wellness in subjects. However, the mechanism of DAG accumulation is not yet fully understood. Methods In this study, gene network of DAG accumulation and fatty acid composition in the two olive mesocarps (“Chenggu 32” (CG) and “Koroneiki” (QJ)) were investigated by integrating lipidome and transcriptome techniques. Results A total of 1,408 lipid molecules were identified by lipidomic analysis in olive mesocarp, of which DAG (DAG36:3

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Stymne, S., та A. K. Stobart. "Biosynthesis of γ-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis)". Biochemical Journal 240, № 2 (1986): 385–93. http://dx.doi.org/10.1042/bj2400385.

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The developing seeds of Borago officinalis (common borage) accumulate a triacylglycerol oil that is relatively rich in the uncommon fatty acid gamma-linolenate (octadec-6,9,12-trienoic acid). Incubation of developing, whole, cotyledons with [14C]oleate and [14C]linoleate showed that the gamma-linolenate was synthesized by the sequential desaturation of oleate—linoleate—gamma-linolenate. Microsomal membrane preparations from the developing cotyledons contained an active delta 6-desaturase enzyme that catalysed the conversion of linoleate into gamma-linolenate. Experiments were designed to manip

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12

Ozols, Juris. "Degradation of Hepatic Stearyl CoA Δ9-Desaturase". Molecular Biology of the Cell 8, № 11 (1997): 2281–90. http://dx.doi.org/10.1091/mbc.8.11.2281.

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Δ9-Desaturase is a key enzyme in the synthesis of desaturated fatty acyl-CoAs. Desaturase is an integral membrane protein induced in the endoplasmic reticulum by dietary manipulations and then rapidly degraded. The proteolytic machinery that specifically degrades desaturase and other short-lived proteins in the endoplasmic reticulum has not been identified. As the first step in identifying cellular factors involved in the degradation of desaturase, liver subcellular fractions of rats that had undergone induction of this enzyme were examined. In livers from induced animals, desaturase was prese

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Liang, Zhenye, Zongzheng Jiang, Sen Wu, Yujia Zhai, Shuqi You, and Chang Xu. "Exogenous Fatty Acids Remodel the Muscle Fatty Acids Composition of the GIFT Tilapia (Oreochromis niloticus)." Aquaculture Research 2024 (March 14, 2024): 1–13. http://dx.doi.org/10.1155/2024/2715178.

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To reduce the negative impact of fish oil substitutes on the fatty acid composition of farmed fish, this experiment utilized different types of oils as dietary lipid sources for GIFT tilapia. Tilapia oil (FO) was used as the control, along with corn oil (CO), linseed oil (LO), algae oil (AO), and a mixture of linseed oil and algae oil in various ratios of 1 : 2, 1 : 1, and 2 : 1 (LA12, LA11, and LA21) to reshape the fatty acid profile of GIFT tilapia (0.205 ± 0.005 g) in the muscle. The weight gain and specific growth rate of tilapia in the LO and control groups were significantly higher than

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RUTTER, Andrew J., Katie L. THOMAS, Derek HERBERT, R. James HENDERSON, David LLOYD, and John L. HARWOOD. "Oxygen induction of a novel fatty acid n−6 desaturase in the soil protozoon, Acanthamoeba castellanii." Biochemical Journal 368, no. 1 (2002): 57–67. http://dx.doi.org/10.1042/bj20020189.

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Induction of fatty acid desaturation is very important for the temperature adaptation of poikilotherms. However, in oxygen-limited late-exponential-phase Acanthamoebacastellanii cultures, oxygen alone was able to induce increased activity of a fatty acid desaturase that converts oleate into linoleate and which has been implicated in the temperature adaptation of this organism. Experiments with Δ10-nonadecenoate showed that the enzyme is an n-6 desaturase rather than a Δ12-desaturase. It also used preferentially 1-acyl-2-oleoyl-phosphatidylcholine as substrate and NAD(P)H as electron donor. The

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Vetchinnikova, Lidia V., Alexander F. Titov, and Tatiana D. Tatarinova. "The Fatty Acid Composition and the Activity of Acyl-Lipid Desaturases in the Buds of Silver Birch in Winter-Spring Period in Karelia and Yakutia." Lesnoy Zhurnal (Forestry Journal), no. 6 (December 10, 2024): 90–105. https://doi.org/10.37482/0536-1036-2024-6-90-105.

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The dynamics of the fatty acid composition and activity of acyl-lipid desaturases contained in the buds of silver birch Betula pendula Roth have been studied. The places of growth of this tree are located in contrasting natural and climatic conditions: at the same latitude – 62° N, but are separated from each other by more than 5 thousand km in the longitudinal direction – 34° E (the vicinity of Petrozavodsk) and 130° E (the vicinity of Yakutsk). It has been found that, regardless of the place of growth, in the spring-winter period, the total lipids of the buds of silver birch have been charac

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Meru, Geoffrey, and Cecilia McGregor. "Quantitative Trait Loci and Candidate Genes Associated with Fatty Acid Content of Watermelon Seed." Journal of the American Society for Horticultural Science 139, no. 4 (2014): 433–41. http://dx.doi.org/10.21273/jashs.139.4.433.

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Seed oil percentage (SOP) and fatty acid composition of watermelon (Citrullus lanatus) seeds are important traits in Africa, the Middle East, and Asia where the seeds provide a significant source of nutrition and income. Oil yield from watermelon seed exceeds 50% (w/w) and is high in unsaturated fatty acids, a profile comparable to that of sunflower (Helianthus annuus) and soybean (Glycine max) oil. As a result of novel non-food uses of plant-derived oils, there is an increasing need for more sources of vegetable oil. To improve the nutritive value of watermelon seed and position watermelon as

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Rezamand, Pedram, Jason S. Watts, Katherine M. Yavah, et al. "Relationship between stearoyl-CoA desaturase 1 gene expression, relative protein abundance, and its fatty acid products in bovine tissues." Journal of Dairy Research 81, no. 3 (2014): 333–39. http://dx.doi.org/10.1017/s0022029914000181.

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Stearoyl-CoA desaturase 1 (SCD1) greatly contributes to the unsaturated fatty acids present in milk and meat of cattle. The SCD1 enzyme introduces a double bond into certain saturated fatty acyl-CoAs producing monounsaturated fatty acids (MUFA). The SCD1 enzyme also has been shown to be active in the bovine mammary gland converting t11 18 : 1 (vaccenic acid) to c9 t11 conjugated linoleic acid (CLA). The objective of this study was to determine any association between the gene expression of SCD1 and occurrence of its products (c9 14 : 1, c9 16 : 1, c9 18 : 1, and c9 t11 18 : 2) in various bovin

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Liu, Hao, Jianzhong Gu, Qing Lu, et al. "Transcriptomic Analysis Reveals the High-Oleic Acid Feedback Regulating the Homologous Gene Expression of Stearoyl-ACP Desaturase 2 (SAD2) in Peanuts." International Journal of Molecular Sciences 20, no. 12 (2019): 3091. http://dx.doi.org/10.3390/ijms20123091.

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Peanuts with high oleic acid content are usually considered to be beneficial for human health and edible oil storage. In breeding practice, peanut lines with high monounsaturated fatty acids are selected using fatty acid desaturase 2 (FAD2), which is responsible for the conversion of oleic acid (C18:1) to linoleic acid (C18:2). Here, comparative transcriptomics were used to analyze the global gene expression profile of high- and normal-oleic peanut cultivars at six time points during seed development. First, the mutant type of FAD2 was determined in the high-oleic peanut (H176). The result sug

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Kawashima, Y., A. Hirose, and H. Kozuka. "Alterations by peroxisome proliferators of acyl composition of hepatic phosphatidylcholine in rats, mice and guinea-pigs. Role of stearoyl-CoA desaturase." Biochemical Journal 235, no. 1 (1986): 251–55. http://dx.doi.org/10.1042/bj2350251.

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Rats, mice and guinea-pigs were administered p-chlorophenoxyisobutyric acid (clofibric acid) or 2,2′-(decamethylenedithio)diethanol (tiadenol). The treatments of rats and mice with either clofibric acid or tiadenol increased markedly the activities of stearoyl-CoA desaturase, palmitoyl-CoA chain elongation, 1-acylglycerophosphate (1-acyl-GP) acyltransferase and 1-acylglycerophosphocholine (1-acyl-GPC) acyltransferase, but not 2-acylglycerophosphocholine (2-acyl-GPC) acyltransferase in liver microsomes. The treatment of guinea-pigs with clofibric acid did not cause any change in the activities

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Mondal, Nupur, K. V. Bhat, P. S. Srivastava, and S. K. Sen. "Effects of domestication bottleneck and selection on fatty acid desaturases in Indian sesame germplasm." Plant Genetic Resources 14, no. 2 (2015): 81–90. http://dx.doi.org/10.1017/s1479262115000106.

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Sesame (Sesamum indicumL.) is one of the oldest and most nutritional oilseed crops, of which domestication history has been poorly understood. This study suggested that sesame has undergone domestication bottleneck during its use for a long time. In this investigation, the molecular analysis included 4.4 Mbp of the genomic DNA of sesame comprising stearoyl acyl desaturase (sad), fatty acid desaturase 2 (fad2) and omega 3 fatty acid desaturase (o3fad) genes in 99 accessions of four populations of sesame germplasm namely: wild species, landraces, improved cultivars and introgressed lines. Result

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Zámbó, Veronika, Gabriella Orosz, Luca Szabó, et al. "A Single Nucleotide Polymorphism (rs3811792) Affecting Human SCD5 Promoter Activity Is Associated with Diabetes Mellitus." Genes 13, no. 10 (2022): 1784. http://dx.doi.org/10.3390/genes13101784.

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The combined prevalence of type 1 (T1DM) and type 2 (T2DM) diabetes mellitus is 10.5% worldwide and this is constantly increasing. The pathophysiology of the diseases include disturbances of the lipid metabolism, in which acyl-CoA desaturases play a central role as they synthesize unsaturated fatty acids, thereby providing protection against lipotoxicity. The stearoyl-CoA desaturase-5 (SCD5) isoform has received little scientific attention. We aimed to investigate the SCD5 promoter and its polymorphisms in vitro, in silico and in a case-control study. The SCD5 promoter region was determined by

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Xiong, Lin, Jie Pei, Xiaoyun Wu, et al. "The Study of the Response of Fat Metabolism to Long-Term Energy Stress Based on Serum, Fatty Acid and Transcriptome Profiles in Yaks." Animals 10, no. 7 (2020): 1150. http://dx.doi.org/10.3390/ani10071150.

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Long-term energy stress (ES) during the cold season is a serious problem for the breeding of yaks. In this paper, the response of fat metabolism in yaks to long-term ES during the cold season was studied. Gas chromatography (GC) analysis showed that the percentage of saturated fatty acids (SFAs) in the subcutaneous fat of the yaks in the ES group was 42.7%, which was less than the 56.6% in the CO group (p < 0.01) and the percentage of polyunsaturated unsaturated fatty acids (PUFAs) in the subcutaneous fat of the yaks in the ES group was 38.3%, which was more than the 26.0% in the CO group (

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Li, Y. H., H. Zhou, L. Cheng, J. Zhao, and J. G. H. Hickford. "Variation in PLIN2 and its association with milk traits and milk fat composition in dairy cows." Journal of Agricultural Science 158, no. 8-9 (2020): 774–80. http://dx.doi.org/10.1017/s0021859621000174.

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AbstractThe current study investigated associations between variation in the bovine perilipin-2 gene (PLIN2) and milk traits (milk fat content, milk protein content, milk yield and milk fatty acid (FA) component levels) in 409 New Zealand pasture-grazed Holstein-Friesian × Jersey-cross (HF × J-cross or Kiwicross™) cows. Five nucleotide sequence variants were found in three regions of the gene, including c.17C>T in exon 2, c.53A>G in exon 3, c.595+23G>A and c.595+104_595+108del in intron 5, and c.*302T>C in the 3′-untranslated region. The c.*302T>C substitution produces two nucle

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Jiang, Chang-Jie, Masaki Shimono, Satoru Maeda, et al. "Suppression of the Rice Fatty-Acid Desaturase Gene OsSSI2 Enhances Resistance to Blast and Leaf Blight Diseases in Rice." Molecular Plant-Microbe Interactions® 22, no. 7 (2009): 820–29. http://dx.doi.org/10.1094/mpmi-22-7-0820.

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Fatty acids and their derivatives play important signaling roles in plant defense responses. It has been shown that suppressing a gene for stearoyl acyl carrier protein fatty-acid desaturase (SACPD) enhances the resistance of Arabidopsis (SSI2) and soybean to multiple pathogens. In this study, we present functional analyses of a rice homolog of SSI2 (OsSSI2) in disease resistance of rice plants. A transposon insertion mutation (Osssi2-Tos17) and RNAi-mediated knockdown of OsSSI2 (OsSSI2-kd) reduced the oleic acid (18:1) level and increased that of stearic acid (18:0), indicating that OsSSI2 is

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Tzeng, Thing-Fong, Shorong-Shii Liou, Chia Ju Chang, and I.-Min Liu. "Zerumbone, a Natural Cyclic Sesquiterpene ofZingiber zerumbetSmith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/303061.

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We investigated the effects of zerumbone, a natural cyclic sesquiterpene, on hepatic lipid metabolism in Syrian golden hamsters fed on high-fat diet (HFD). After being fed HFD for 2 weeks, hamsters were dosed orally with zerumbone (75, 150, and 300 mg kg−1) once daily for 8 weeks. After treatment with zerumbone, the plasma levels of total cholesterol (TC) and triglycerides (TGs) and the contents of TC and TG in hepatic tissue as well as homeostasis model assessment of insulin resistance were lowered, especially in the zerumbone-treated group (300 mg kg−1). Moreover, the histological evaluation

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Hai, Yang, Ling Zuo, Meng Wang, et al. "Icariin Alleviates Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome by Improving Liver Fatty Acid Oxidation and Inhibiting Lipid Accumulation." Molecules 28, no. 2 (2023): 517. http://dx.doi.org/10.3390/molecules28020517.

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(1) Background: Icariin is the main component of the Chinese herb Epimedium. A number of studies have shown that it alleviates abnormal lipid metabolism. However, it is not clear whether and how icariin can ameliorate hepatic steatosis with polycystic ovary syndrome (PCOS). This study was designed to explore the anti-hepatosteatosis effect of icariin in rats with polycystic ovary syndrome. (2) Methods: Female Sprague Dawley(SD)rats were treated with a high-fat diet and letrozole for 21 days to make nonalcoholic fatty liver disease (NAFLD) in the polycystic ovary syndrome model. Then model rats

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Park, Jae-Eun, та Ji-Sook Han. "(E)-5-hydroxy-7-methoxy-3-(2-hydroxybenzyl)-4-chromanone, a Major Homoisoflavonoid, Attenuates Free Fatty Acid-Induced Hepatic Steatosis by Activating AMPK and PPARα Pathways in HepG2 Cells". Nutrients 16, № 20 (2024): 3475. http://dx.doi.org/10.3390/nu16203475.

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Background: (E)-5-hydroxy-7-methoxy-3-(2-hydroxybenzyl)-4-chromanone (HMC), a homoisoflavonoid isolated from Portulaca oleracea, has significant anti-adipogenesis potential; it regulates adipogenic transcription factors. However, whether HMC improves hepatic steatosis in hepatocytes remains vague. This study investigated whether HMC ameliorates hepatic steatosis in free fatty acid-treated human hepatocellular carcinoma (HepG2) cells, and if so, its mechanism of action was analyzed. Methods: Hepatic steatosis was induced by a free fatty acid mixture in HepG2 cells. Thereafter, different HMC con

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Shajahan, Ferosekhan, Hanlin Xu, Serhat Turkmen, et al. "Reproductive performance of gilthead seabream (Sparus aurata) broodstock showing different expression of fatty acyl desaturase 2 and fed two dietary fatty acid profiles." Scientific Reports 10, no. 1 (2020): 15547. https://doi.org/10.1038/s41598-020-72166-5.

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Previous studies have shown that it is possible to nutritionally program gilthead seabream offspring through fish oil (FO) replacement by vegetable oils (VO) in the broodstock diet, to improve their ability to grow fast when fed low fish meal (FM) and FO diets during grow-out phase. However, in those studies broodstock performance was reduced by the VO contained diet. Therefore, the present study aimed to determine if it is possible to replace FO by a mixture of FO and rapeseed oil (RO) with a specific fatty acid profile in broodstock diets, without altering gilthead seabream broodstock reprod

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Monroig, Óscar, Juan C. Navarro, James R. Dick, Frederic Alemany та Douglas R. Tocher. "Identification of a Δ5-like Fatty Acyl Desaturase from the Cephalopod Octopus vulgaris (Cuvier 1797) Involved in the Biosynthesis of Essential Fatty Acids". Marine Biotechnology 14, № 4 (2011): 411–22. http://dx.doi.org/10.1007/s10126-011-9423-2.

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Zhang, Qingyu, Rui Yu, Daoyang Sun та ін. "Comparative Transcriptome Analysis Reveals an Efficient Mechanism of α-Linolenic Acid in Tree Peony Seeds". International Journal of Molecular Sciences 20, № 1 (2018): 65. http://dx.doi.org/10.3390/ijms20010065.

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Tree peony (Paeonia section Moutan DC.) species are woody oil crops with high unsaturated fatty acid content, including α-linolenic acid (ALA/18:3; >40% of the total fatty acid). Comparative transcriptome analyses were carried out to uncover the underlying mechanisms responsible for high and low ALA content in the developing seeds of P. rockii and P. lutea, respectively. Expression analysis of acyl lipid metabolism genes revealed upregulation of select genes involved in plastidial fatty acid synthesis, acyl editing, desaturation, and triacylglycerol assembly in seeds of P. rockii relative t

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Pan, Zhiqiang, Agnes M. Rimando, Scott R. Baerson, Mark Fishbein та Stephen O. Duke. "Functional Characterization of Desaturases Involved in the Formation of the Terminal Double Bond of an Unusual 16:3Δ9, 12, 15 Fatty Acid Isolated from Sorghum bicolor Root Hairs". Journal of Biological Chemistry 282, № 7 (2006): 4326–35. http://dx.doi.org/10.1074/jbc.m606343200.

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Sorgoleone, produced in root hair cells of sorghum (Sorghum bicolor), is likely responsible for much of the allelopathic properties of sorghum root exudates against broadleaf and grass weeds. Previous studies suggest that the biosynthetic pathway of this compound initiates with the synthesis of an unusual 16:3 fatty acid possessing a terminal double bond. The corresponding fatty acyl-CoA serves as a starter unit for polyketide synthases, resulting in the formation of 5-pentadecatrienyl resorcinol. This resorcinolic intermediate is then methylated by an S-adenosylmethionine-dependent O-methyltr

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Manor, Meghan L., Theodore J. Derksen, Andrew D. Magnuson, Fahad Raza та Xin Gen Lei. "Inclusion of Dietary Defatted Microalgae Dose-Dependently Enriches ω-3 Fatty Acids in Egg Yolk and Tissues of Laying Hens". Journal of Nutrition 149, № 6 (2019): 942–50. http://dx.doi.org/10.1093/jn/nxz032.

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ABSTRACT Background The potential for dietary microalgae to enrich eggs of laying hens with ω-3 (n–3) fatty acids, and the mechanisms involved, are unclear. Objectives The aim of this study was to determine the effects and molecular regulation of a defatted Nannochloropsis oceanica microalgae (DNOM) biomass on the enrichment of the eggs and tissues of laying hens with ω-3 fatty acids. Methods Fifty Shaver-White Leghorn hens (46 wk of age, body weight: 1.70 ± 0.27 kg) were individually caged (n = 10) and fed a corn-soy–based diet supplemented with DNOM at 0% (control), 2.86%, 5.75%, 11.5%, and

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Zhang, Hang, Ni Dan, Changjin Ao, Sizhen Wang, Khas Erdene, and Mohammed Umair Ashraf. "Effects of exogenous C18 unsaturated fatty acids on milk lipid synthesis in bovine mammary epithelial cells." Journal of Dairy Research 87, no. 3 (2020): 344–48. http://dx.doi.org/10.1017/s0022029920000722.

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AbstractWe determined the effects of a combination of C18 unsaturated fatty acids (C18-UFAs) consisting of oleic, linoleic, and linolenic acids on milk lipogenesis in bovine mammary epithelial cells (BMECs). By orthogonal experiments to determine cellular triacylglycerol (TAG) accumulation, a combination of 200 μmol/l C18 : 1, 50 μmol/l C18 : 2, and 2 μmol/l C18 : 3 was selected as C18-UFAs combination treatment, and culture in medium containing fatty acid-free bovine serum albumin was used as the control. The expression of genes related to milk lipid synthesis and intracellular FA composition

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Xu, Hanlin, Shajahan Ferosekhan, Serhat Turkmen, Juan Manuel Afonso, María Jesús Zamorano, and Marisol Izquierdo. "Influence of Parental Fatty Acid Desaturase 2 (fads2) Expression and Diet on Gilthead Seabream (Sparus aurata) Offspring fads2 Expression during Ontogenesis." Animals 10, no. 11 (2020): 2191. http://dx.doi.org/10.3390/ani10112191.

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Previous studies have shown that it is possible to increase the ability of marine fish to produce long-chain polyunsaturated fatty acid from their 18C precursors by nutritional programming or using broodstock with a higher fatty acyl desaturase 2 (fads2) expression. However, those studies failed to show the effect of these interventions on the expression of the fads2 gene in the developing egg. Moreover, there were no studies on the temporal expression of the fads2 during ontogeny in the gilthead sea bream (Sparus aurata). In order to determine the changes in expression of fads2 during ontogen

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Xiong, Lin, Jie Pei, Xiaoyun Wu, Pengjia Bao, Xian Guo, and Ping Yan. "Explaining Unsaturated Fatty Acids (UFAs), Especially Polyunsaturated Fatty Acid (PUFA) Content in Subcutaneous Fat of Yaks of Different Sex by Differential Proteome Analysis." Genes 13, no. 5 (2022): 790. http://dx.doi.org/10.3390/genes13050790.

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Residents on the Tibetan Plateau intake a lot of yak subcutaneous fat by diet. Modern healthy diet ideas demand higher unsaturated fatty acids (UFAs), especially polyunsaturated fatty acid (PUFA) content in meat. Here, the gas chromatography (GC) and tandem mass tag (TMT) proteomic approaches were applied to explore the relationship between the proteomic differences and UFA and PUFA content in the subcutaneous fat of yaks with different sex. Compared with male yaks (MYs), the absolute contents of UFAs, monounsaturated fatty acids (MUFAs) and PUFAs in the subcutaneous fat of female yaks (FYs) w

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Fang, Yan, Jeffrey A. Coulter, Junyan Wu, et al. "Identification of differentially expressed genes involved in amino acid and lipid accumulation of winter turnip rape (Brassica rapa L.) in response to cold stress." PLOS ONE 16, no. 2 (2021): e0245494. http://dx.doi.org/10.1371/journal.pone.0245494.

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Winter turnip rape (Brassica rapa L.) is an important overwintering oil crop that is widely planted in northwestern China. It considered to be a good genetic resource for cold-tolerant research because its roots can survive harsh winter conditions. Here, we performed comparative transcriptomics analysis of the roots of two winter turnip rape varieties, Longyou7 (L7, strong cold tolerance) and Tianyou2 (T2, low cold tolerance), under normal condition (CK) and cold stress (CT) condition. A total of 8,366 differentially expressed genes (DEGs) were detected between the two L7 root groups (L7CK_VS_

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Zaüner, Simone, Ulrich Zähringer, Buko Lindner, Dirk Warnecke та Petra Sperling. "Identification and Functional Characterization of the 2-Hydroxy FattyN-Acyl-Δ3(E)-desaturase fromFusarium graminearum". Journal of Biological Chemistry 283, № 52 (2008): 36734–42. http://dx.doi.org/10.1074/jbc.m807264200.

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Liang, Manman, Xuemei Zhang, Qinglong Dong, et al. "Metabolomics and Transcriptomics Provide Insights into Lipid Biosynthesis in the Embryos of Walnut (Juglans regia L.)." Plants 12, no. 3 (2023): 538. http://dx.doi.org/10.3390/plants12030538.

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Walnut (Juglans regia L.) is an important woody o ilseed tree species due to its commercial value. However, the regulation mechanism of walnut oil accumulation is still poorly understood, which restricted the breeding and genetic improvement of high-quality oil-bearing walnuts. In order to explore the metabolic mechanism that regulates the synthesis of walnut oil, we used transcriptome sequencing technology and metabolome technology to comprehensively analyze the key genes and metabolites involved in oil synthesis of the walnut embryo at 60, 90, and 120 days after pollination (DAP). The result

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Ferreri, Carla, Alessandra Ferocino, Gessica Batani, et al. "Plasmalogens: Free Radical Reactivity and Identification of Trans Isomers Relevant to Biological Membranes." Biomolecules 13, no. 5 (2023): 730. http://dx.doi.org/10.3390/biom13050730.

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Plasmalogens are membrane phospholipids with two fatty acid hydrocarbon chains linked to L-glycerol, one containing a characteristic cis-vinyl ether function and the other one being a polyunsaturated fatty acid (PUFA) residue linked through an acyl function. All double bonds in these structures display the cis geometrical configuration due to desaturase enzymatic activity and they are known to be involved in the peroxidation process, whereas the reactivity through cis-trans double bond isomerization has not yet been identified. Using 1-(1Z-octadecenyl)-2-arachidonoyl-sn-glycero-3-phosphocholin

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Song, Hui, Liping Zhu, Clive M. Picardo, et al. "Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism." American Journal of Physiology-Endocrinology and Metabolism 290, no. 1 (2006): E17—E25. http://dx.doi.org/10.1152/ajpendo.00597.2004.

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Complete lecithin:cholesterol acyltransferase (LCAT) deficiency is associated with fasting hypertriglyceridemia (HTG). We recently reported that, in ldlr−/−×lcat−/− mice, fasting HTG is associated with hepatic triglyceride overproduction in association with an upregulation of the hepatic srebp1 gene and altered expression of its target genes in lipogenesis and gluconeogenesis. We further investigated the role of hepatic polyunsaturated fatty acid (PUFA) metabolism in the modulation of the lipid phenotypes. In the ldlr−/−×lcat−/− mice, using the ldlr−/−×lcat+/+ littermate as controls, the hepat

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Marchitelli, Cinzia, Giovanna Contarini, Giovanna De Matteis, et al. "Milk fatty acid variability: effect of some candidate genes involved in lipid synthesis." Journal of Dairy Research 80, no. 2 (2013): 165–73. http://dx.doi.org/10.1017/s002202991300006x.

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In this work, the genetic variation of milk FA was investigated in three different bovine breeds, the Jersey, the Piedmontese and the Valdostana, and at different lactation stages. All animals were genotyped for 21 Single Nucleotide Polymorphisms located within nine candidate genes involved in lipid synthesis: diacylglycerol acyltransferase 1 and 2 (DGAT1, 2); stearoyl-CoA desaturase (SCD); growth hormone receptor (GHR); fatty acid synthase (FASN); acyl-CoA dehydrogenase (ACAD); fatty acid binding protein (FABP4); lipoprotein lipase (LPL); and leptin gene (LEP). The highest milk-fat Jersey bre

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Lei, Shan-Shan, Ning-Yu Zhang, Fu-Chen Zhou, et al. "Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice." Evidence-Based Complementary and Alternative Medicine 2021 (March 19, 2021): 1–12. http://dx.doi.org/10.1155/2021/6689727.

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Dendrobium officinale (DOF) is a traditional Chinese edible and officinal plant. Ultrafine DOF powder (DOFP) can regulate lipids and histopathology in the liver, but the underlying mechanisms of hepatic fatty acid (FA) metabolism, which is generally correlated with the development of nonalcoholic fatty liver disease (NAFLD), remain unclear. The purpose of the present study was to investigate whether DOFP treatment alters hepatic FA metabolism in NAFLD mice by using multidimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) and analyse the underlying mechanisms. A 3-week DOFP treatme

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Shi, Mengyu, Yisong He, Jiajun Zheng, et al. "Effects of Soybean Isoflavones on the Growth Performance and Lipid Metabolism of the Juvenile Chinese Mitten Crab Eriocheir sinensis." Fishes 9, no. 9 (2024): 335. http://dx.doi.org/10.3390/fishes9090335.

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In order to study the effects of soybean isoflavones on the growth performance and lipid metabolism of juvenile Chinese mitten crabs, six experimental diets were formulated by gradient supplementation with 0%, 0.004% and 0.008% soybean isoflavones at different dietary lipid levels (10% and 15%). The groups were named as follows: NF-0 group (10% fat and 0% SIFs), NF-0.004 group (10% fat and 0.004% SIFs), NF-0.008 group (10% fat and 0.008% SIFs), HF-0 group (15% fat and 0% SIFs), HF-0.004 group (15% fat and 0.004% SIFs) and HF-0.008 group (15% fat and 0.008% SIFs). All crabs with an initial weig

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Ahmad, Ahmad, Firdayani Firdayani, and Irma Kartika. "Virtual Screening Bioactive Compounds of Rheum Genus in Inhibiting Steatohepatitis: In silico studies." Turkish Computational and Theoretical Chemistry 9, no. 2 (2024): 52–65. https://doi.org/10.33435/tcandtc.1506442.

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The fatty liver disease known as steatohepatitis is characterized by liver inflammation. De novo lipogenesis and mevalonate pathway have been identified as contributing to the development of fatty liver. Rheum genus has pharmacological properties such as antioxidant, anti-inflammatory, hepatoprotective, and hypolipidemic. Consequently, the current study investigated bioactive compounds from Rheum genus using in-silico method. The 109 compounds and their natural inhibitors against the enzyme targets ATP-citrate lyase (ACLY), Acetyl-CoA carboxylase (ACC), Fatty Acid Synthase (FASN), Stearoyl-CoA

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Li, Yunchang, Xiaojing Zhang, Zhenyu Xia, and Yue Hao. "Dissecting the Molecular Mechanism of 10-HDA Biosynthesis: Role of Acyl-CoA Delta(11) Desaturase and Transcriptional Regulators in Honeybee Mandibular Glands." Insects 16, no. 6 (2025): 563. https://doi.org/10.3390/insects16060563.

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10-Hydroxy-2-decenoic acid (10-HDA), a major fatty acid (FA) component of royal jelly, is synthesized in the mandibular glands (MGs) of worker honeybees. Despite its well-documented nutritional and therapeutic significance, the biosynthetic pathway and regulatory mechanisms of 10-HDA production remain largely unresolved. In this study, the molecular basis of 10-HDA biosynthesis and regulation in the MGs of newly emerged bees (NEBs), nurse bees (NBs), and forager bees (FBs) were investigated using RNA sequencing and weighted gene co-expression network analysis (WGCNA). A five-step biosynthetic

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WILLIAMS, John P., Valerie IMPERIAL, Mobashsher U. KHAN, and Joanna N. HODSON. "The role of phosphatidylcholine in fatty acid exchange and desaturation in Brassica napus L. leaves." Biochemical Journal 349, no. 1 (2000): 127–33. http://dx.doi.org/10.1042/bj3490127.

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The role of phosphatidylcholine (PC) in fatty acid exchange and desaturation was examined and compared with that of monogalactosyldiacylglycerol (MGDG) in Brassica napus leaves using 14C-labelling in vivo. Data are presented which indicate that in the chloroplast newly formed saturated (palmitic acid, 16:0) and monounsaturated (oleic acid, 18:1) fatty acid is incorporated into MGDG and desaturated in situ. In the non-plastidic compartments, however, newly formed fatty acid is exchanged with polyunsaturated fatty acid in PC, the probable major site of subsequent desaturation. The unsaturated fa

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Turkmen, Serhat, Carmen M. Hernández-Cruz, María J. Zamorano, et al. "Long-chain PUFA profiles in parental diets induce long-term effects on growth, fatty acid profiles, expression of fatty acid desaturase 2 and selected immune system-related genes in the offspring of gilthead seabream." British Journal of Nutrition 122, no. 1 (2019): 25–38. http://dx.doi.org/10.1017/s0007114519000977.

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AbstractThe present study investigated the effects of nutritional programming through parental feeding on offspring performance and expression of selected genes related to stress resistance in a marine teleost. Gilthead seabream broodstock were fed diets containing various fish oil (FO)/vegetable oil ratios to determine their effects on offspring performance along embryogenesis, larval development and juvenile on-growing periods. Increased substitution of dietary FO by linseed oil (LO) up to 80 % LO significantly reduced the total number of eggs produced by kg per female per spawn. Moreover, a

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Jiang, Y., X. D. Liao, M. Xie, et al. "Dietary threonine supplementation improves hepatic lipid metabolism of Pekin ducks." Animal Production Science 59, no. 4 (2019): 673. http://dx.doi.org/10.1071/an17633.

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The present study was conducted to evaluate the regulatory role of threonine (Thr) on hepatic lipid metabolism by determining the effects of dietary Thr concentration on lipid deposition and on genes related to lipid expression in the liver of Pekin duck. In total, 240 1-day-old ducklings were randomly allocated according to the average bodyweight to one of five dietary treatments with six replicate cages of eight birds per cage for each treatment. Birds were fed diets with 0.52%, 0.59%, 0.66%, 0.73% and 0.80% Thr (as-fed basis) from 1 to 21 days of age respectively. The results showed that di

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Jiao, Emilie An An, Kei Ching Yuen, Bai Lin Li, and Chun Fung Sin. "Abstract 353: Investigate the role of homoharringtonine in treating B-cell acute lymphoblastic leukemia." Cancer Research 84, no. 6_Supplement (2024): 353. http://dx.doi.org/10.1158/1538-7445.am2024-353.

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Abstract B lymphoblastic leukemia (B-ALL) is an aggressive and highly lethal hematolymphoid malignancy and it is the most common cancer in children. Although the incidence of B-ALL in adult is lower than that in children, adult patients with B-ALL have a poor prognosis. Relapse/refractory disease is still the main cause of death in B-ALL patients. Homoharringtonine (HHT) is a plant alkaloid that was approved to treat chronic myeloid leukemia (CML) by FDA. Herein, we aimed to investigate the anti-leukemic activity of HHT in B-ALL. Cell viability was reduced in a time and dose-dependent manner u

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Ferosekhan, Shajahan, Serhat Turkmen, Hanlin Xu, et al. "The Relationship between the Expression of Fatty Acyl Desaturase 2 (fads2) Gene in Peripheral Blood Cells (PBCs) and Liver in Gilthead Seabream, Sparus aurata Broodstock Fed a Low n-3 LC-PUFA Diet." Life 10, no. 7 (2020): 117. http://dx.doi.org/10.3390/life10070117.

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The principle aim of this study is to elucidate the relationship between the fatty acid desaturase 2 gene (fads2) expression pattern in peripheral blood cells (PBCs) and liver of gilthead seabream (GSB), Sparus aurata broodstock in order to determine the possible use of fads2 expression as a potential biomarker for the selection of broodstock. This selection could be utilized for breeding programs aiming to improve reproduction, health, and nutritional status. Passive Integrated Transponder (PIT)-tagged GSB broodstock (Male-1.22 ± 0.20 kg; 44.8 ± 2 cm and female-2.36 ± 0.64 kg; 55.1 cm) were f

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