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Dissertations / Theses on the topic 'Gastrulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Bobbs, Alexander Sebastian. "FGF Signaling During Gastrulation and Cardiogenesis." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/265335.

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An early event in animal development is the formation of the three primary germ layers that define the body plan. During gastrulation, cells migrate through the primitive streak of the embryo and undergo changes in morphology and gene expression, thus creating the mesodermal and endodermal cell layers. Gastrulation requires expression of Fibroblast Growth Factor (FGF), Wnt, and Platelet-Derived Growth Factor (PDGF). Embryos treated with FGF inhibitors fail to gastrulate, as cell migration is completely halted. During gastrulation, 44 microRNAs are expressed in the primitive streak of G. gallus

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2

Nie, Shuyi. "Regulation of vertebrate gastrulation by ErbB signaling." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. http://www.mhsl.uab.edu/dt/2007p/nie.pdf.

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3

Pouille, Philippe-Alexandre. "Biomécanique de la gastrulation chez Drosophila Melanogaster." Paris 7, 2009. http://www.theses.fr/2009PA077048.

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L'embryogenèse implique les réseaux d'interaction de gènes, la différenciation épigénétique et les cascades biochimiques, mais aussi les propriétés physiques des tissus, afin de contrôler précisément les changements morphologiques. Le modèle animal est Drosophila Melanogaster] l'événement morphogénétique étudié est l'invagination du mésoderme ventral lors de la gastrulation, qui se déroule en deux étapes principales : une phase lente de constriction stochastique des apex suivie d'une phase rapide de contraction globale. La thèse analyse les composants biomécaniques de l'embryon précoce et la d

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4

Wadsworth, Richard Lee. "The Role of SRGAP2 in Vertebrate Gastrulation." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/420865.

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Biology<br>Ph.D.<br>During vertebrate gastrulation, an elaborate series of cellular motility events occur that define the three germ layers, and establishes the primary body axis. While it is known that non-canonical Wnt signaling plays a crucial role during this period of development, a complete picture of the molecular mechanisms controlling this pathway has yet to be established. Previous studies has shown that one essential component of the pathway linking the Wnt ligands to the cytoskeletal changes that occur during vertebrate development is Dishevelled-associated activator of morphogenes

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5

Link, Vinzenz. "Identification of proteins controlling gastrulation movements by a proteomic approach in zebrafish." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1145519075954-75369.

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During vertebrate gastrulation, a well-orchestrated series of cell movements leads to the formation of the three germ layers: ectoderm, mesoderm and endoderm. In zebrafish, a model organism for vertebrate development, the mesendodermal progenitor cells separate from the ectodermal cells and migrate towards the animal pole. To identify proteins controlling these processes, I used a comparative proteomic approach following two alternative strategies: (1) Based on the notion that Wnt11 regulates cell movement and morphology during gastrulation independent of transcriptional regulation, I performe

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6

Ulrich, Florian. "Regulation of Zebrafish Gastrulation Movements by slb/wnt11." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1125651469323-78929.

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During zebrafish gastrulation, highly coordinated cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Recent studies have identified silberblick (slb/wnt11) as a key molecule that regulates gastrulation movement through a conserved pathway, which shares significant similarity with a signalling pathway that establishes epithelial planar cell polarity (PCP) in Drosophila (Heisenberg et al., 2000; Veeman et al., 2003), suggesting a role for cell polarity in regulating gastrulation movements. However, the cellular and molecular mechanisms by whi

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7

Gerstner, Norman. "Endocytic Modulation of Developmental Signaling during Zebrafish Gastrulation." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-156636.

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Biological information processing in living systems like cells, tissues and organs critically depends on the physical interactions of molecular signaling components in time and space. How endocytic transport of signaling molecules contributes to the regulation of developmental signaling in the complex in vivo environment of a developing organism is not well understood. In a previously performed genome-wide screen on endocytosis, several genes have been identified, that selectively regulate transport of signaling molecules to different types of endosomes, without disrupting endocytosis. My Ph

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8

Solimena, Michele, Jakob Suckale, Olivia Wendling, et al. "PTBP1 Is Required for Embryonic Development before Gastrulation." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-191525.

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Polypyrimidine-tract binding protein 1 (PTBP1) is an important cellular regulator of messenger RNAs influencing the alternative splicing profile of a cell as well as its mRNA stability, location and translation. In addition, it is diverted by some viruses to facilitate their replication. Here, we used a novel PTBP1 knockout mouse to analyse the tissue expression pattern of PTBP1 as well as the effect of its complete removal during development. We found evidence of strong PTBP1 expression in embryonic stem cells and throughout embryonic development, especially in the developing brain and spinal

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9

Moly, Pricila K., James R. Cooley, Sebastian L. Zeltzer, Tatiana A. Yatskievych, and Parker B. Antin. "Gastrulation EMT Is Independent of P-Cadherin Downregulation." Public Library of Science, 2016. http://hdl.handle.net/10150/614679.

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Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved process during which cells lose epithelial characteristics and gain a migratory phenotype. Although downregulation of epithelial cadherins by Snail and other transcriptional repressors is generally considered a prerequisite for EMT, recent studies have challenged this view. Here we investigate the relationship between E-cadherin and P-cadherin expression and localization, Snail function and EMT during gastrulation in chicken embryos. Expression analyses show that while E-cadherin transcripts are detected in the epiblast but

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10

Solimena, Michele, Jakob Suckale, Olivia Wendling, et al. "PTBP1 Is Required for Embryonic Development before Gastrulation." Public Library of Science, 2011. https://tud.qucosa.de/id/qucosa%3A29128.

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Polypyrimidine-tract binding protein 1 (PTBP1) is an important cellular regulator of messenger RNAs influencing the alternative splicing profile of a cell as well as its mRNA stability, location and translation. In addition, it is diverted by some viruses to facilitate their replication. Here, we used a novel PTBP1 knockout mouse to analyse the tissue expression pattern of PTBP1 as well as the effect of its complete removal during development. We found evidence of strong PTBP1 expression in embryonic stem cells and throughout embryonic development, especially in the developing brain and spinal

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11

Yamada, Sachiko. "Twisted Gastrulation, a BMP Antagonist, Exacerbates Podocyte Injury." Kyoto University, 2019. http://hdl.handle.net/2433/242348.

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12

Buchan, Nina Elizabeth. "The regulation of convergent extension during gastrulation in zebrafish." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446226/.

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Coordinated cell movements during zebrafish gastrulation shape the embryo, forming three germ layers and establishing the embryonic body plan. Through convergent extension (CE) movements, mesodermal and neurectodermal cells intercalate at the dorsal midline, extending the anteroposterior axis. CE has been shown to be regulated by non-canonical Wnt signalling, homologous to planar cell polarity (PCP) signalling in Drosophila. In this thesis, I undertook several different approaches to understand the molecular mechanisms by which non-canonical Wnt/PCP signalling regulates CE. Firstly, I characte

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13

Ingram, Damien. "Induction of the murine Brachyury promoter." Thesis, University of Warwick, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484286.

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14

Szenker, Emmanuelle. "Etude des variants de l'histoire H3 : H3. 2 et H3. 3, au cours du développement embryonnaire d'un vertébré, Xenopus laevis." Paris 6, 2012. http://www.theses.fr/2012PA066469.

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L’organisation en chromatine permet de compacter l’ADN génomique et de réguler finement l’expression du génome. La particule cœur du nucléosome, composée d’un octamère de protéines histones autour desquelles s’enroule l’ADN, peut être modulée par l’incorporation de variants d’histones. Pour l’histone H3, les variants réplicatifs H3. 1 et H3. 2 permettent une incorporation lors de la réplication de l’ADN, tandis que le variant H3. 3 est incorporé tout au long du cycle cellulaire. Les données dans la littérature établissent un lien entre H3. 3 et la transcription. L’incorporation d’H3. 3 dépend

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15

Thermes, Violette. "Contrôle génétique de la prolifération cellulaire chez le médaka : analyses fonctionnelles et amélioration de la transgénèse grâce à l'utilisation de la méganucléase I-SceI." Paris 11, 2004. http://www.theses.fr/2004PA112295.

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Le développement embryonnaire fait appel aux processus de la division, de l’apoptose, de la migration et de la différenciation cellulaire. Leur coordination permet aux organes d’acquérir leur fonction et leur morphologie exactes. Afin d’isoler de nouveaux régulateurs impliqués dans le contrôle de la prolifération cellulaire, un crible génétique par hybridation in situ a été réalisé sur des embryons de médaka (Oryzias latipes). L’objectif est de caractériser in vivo la fonction de gènes issus de ce crible. Dans un premier temps, j’ai contribué à mettre en évidence le rôle de régulateur négatif

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16

Byrum, Christine Annette. "A cellular analysis of gastrulation by unipolar ingression in the hydrozoan Phialidium (Clytia) gregarium /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008293.

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17

Frazzetto, Giovanni. "Xmc, a novel Xenopus laevis organiser : gene regulating gastrulation movements." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268764.

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18

Howard, James E. "Mesoderm induction and the control of gastrulation in Xenopus laevis." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314845.

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19

Rashbass, Penny. "Further analysis of Brachyury (T) : a gene required during gastrulation." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20745.

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This thesis is concerned with further analysis of the classical mouse mutant <I>Brachyury (T)</I>. Developmental genetics has shown that this gene plays a key role in mesoderm formation during murine gastrulation. Although the <I>Brachyury</I> gene is only expressed in the primitive streak, nascent mesoderm and notochord of the gastrulating mouse embryo, homozygous null <I>T/T</I> mutants have a defective allantois, kinked neural tube and disorganized somites in addition to a bulky primitive streak and disrupted notochord. To study the cell autonomy of the <I>T</I> mutation, we have isolated a

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20

Veeman, Michael Terrence. "Zebrafish prickle : non-canonical Wnt/PCP functions in vertebrate gastrulation /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/4999.

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21

Moreau, Chloé. "From lateral plate mesoderm formation to limb position - Linking hox collinear activation and forelimb position in birds." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066492/document.

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La position des membres le long du corps est reproductible chez une même espèce mais est très variable entre différentes espèces. Comment les membres acquièrent leur position et quel mécanisme est à l'origine de ces variations est à ce jour non élucidé. De part leur rôle dans la mise en place des axes embryonnaires, les gènes Hox sont depuis longtemps suspectés de jouer un rôle dans ce processus. Cependant les différentes preuves disponibles à ce jour restent indirectes et corrélatives. Chez l'embryon de poulet, je montre que la position des membres est établit précocement au cours du développ

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22

Giger, Florence. "Internalisation mechanisms of the endoderm during gastrulation in the zebrafish embryo." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066203/document.

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Au cours du développement, les cellules sont progressivement séparées dans des territoires distincts délimités par des frontières embryonnaires. La première ségrégation a lieu pendant la gastrulation, quand l’embryon s’organise en trois feuillets embryonnaires, l’ectoderme, le mésoderme et l’endoderme. Les mécanismes moléculaires et cellulaires assurant cette ségrégation n’ont pas encore été élucidés. Au cours de ma thèse, je me suis focalisée sur l’internalisation de l’endoderme chez le poisson-zèbre. À partir de résultats in vitro, il a été suggéré que les progéniteurs de feuillets embryonna

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23

Suriben, Rowena Mae Obina. "Dact1 functions in the planar cell polarity pathway during vertebrate gastrulation." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390079.

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24

Arboleda-Estudillo, Yoana. "Mechanical cell properties in germ layer progenitor migration during zebrafish gastrulation." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-27725.

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Gastrulation leads to the formation of the embryonic germ layers, ectoderm, mesoderm and endoderm, and is the first key morphogenetic process that occurs in development. Gastrulation provides a unique developmental assay system in which to study cellular movements and rearrangements in vivo. The different cell movements occurring during gastrulation take place in a highly coordinated spatial and temporal manner, indicating that they must be controlled by a complex interplay of morphogenetic and inductive events. Generally, cell movement constitutes a highly integrated program of different ce

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25

Barclay, Jane. "Physical and genetic analyses of the mouse gastrulation mutant t'w'1'8." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244729.

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26

Barbosa, Filipa Carreira de Avelar. "Regulation of gastrulation movements by planar cell polarity genes in zebrafish." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444345/.

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During vertebrate gastrulation, mesodermal and ectodermal cells undergo convergent extension (CE), a process characterised by cellular rearrangements in which polarised cells intercalate along the medio-lateral axis leading to elongation of the antero-posterior axis. This thesis aims to prove that genes which have been implicated in the establishment of planar cell polarity (PCP) in Drosophila are conserved in the non-canonical Wnt pathway that regulates CE in zebrafish during gastrulation. Firstly, I analyzed functions of Wnt5 and Wnt 11 ligands and of Fz2 and Fz7 receptors in regulating CE m

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Spoor, Willemijn Magda Elly Maria. "Cell based 3 dimensional computational model for gastrulation in chick embryos." Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505600.

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28

Arboleda-Estudillo, Yoana. "Mechanical cell properties in germ layer progenitor migration during zebrafish gastrulation." Doctoral thesis, Max-Planck-Institut für Molekulare Zellbiologie und Genetik, 2009. https://tud.qucosa.de/id/qucosa%3A25271.

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Gastrulation leads to the formation of the embryonic germ layers, ectoderm, mesoderm and endoderm, and is the first key morphogenetic process that occurs in development. Gastrulation provides a unique developmental assay system in which to study cellular movements and rearrangements in vivo. The different cell movements occurring during gastrulation take place in a highly coordinated spatial and temporal manner, indicating that they must be controlled by a complex interplay of morphogenetic and inductive events. Generally, cell movement constitutes a highly integrated program of different ce

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29

Dräger, Sarah [Verfasser], and Sebastian Johannes [Akademischer Betreuer] Arnold. "Expressionsanalyse neu identifizierter potenzieller Zielgene von Eomesodermin während der Maus-Gastrulation." Freiburg : Universität, 2013. http://d-nb.info/1123476969/34.

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30

Giger, Florence. "Internalisation mechanisms of the endoderm during gastrulation in the zebrafish embryo." Electronic Thesis or Diss., Paris 6, 2016. http://www.theses.fr/2016PA066203.

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Au cours du développement, les cellules sont progressivement séparées dans des territoires distincts délimités par des frontières embryonnaires. La première ségrégation a lieu pendant la gastrulation, quand l’embryon s’organise en trois feuillets embryonnaires, l’ectoderme, le mésoderme et l’endoderme. Les mécanismes moléculaires et cellulaires assurant cette ségrégation n’ont pas encore été élucidés. Au cours de ma thèse, je me suis focalisée sur l’internalisation de l’endoderme chez le poisson-zèbre. À partir de résultats in vitro, il a été suggéré que les progéniteurs de feuillets embryonna

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31

Quesada, Hernandez Elena. "The Role of Cell Division Orientation during Zebrafish Early Development." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-64735.

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The development of multicellular organisms is dependent on the tight coordination between tissue growth and morphogenesis. The stereotypical orientation of cell divisions has been proposed to be a fundamental mechanism by which proliferating and growing tissues take shape. However, the actual contribution of stereotypical cell division orientation (SDO) to tissue morphogenesis is unclear. In zebrafish, cell divisions with stereotypical orientation have been implicated in both body axis elongation and neural rod formation, although there is little direct evidence for a critical function of SDO

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Zülch, Armin Uwe. "Funktionsanalyse des Irx1-Gens Irx1 - ein Vormustergen essentiell für die murine Gastrulation /." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962794236.

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Rogers, Ian. "Teratogenic and molecular methods for the study of mouse gastrulation and neurulation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0004/NQ41299.pdf.

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Cobo, Rodriguez I. "Role of Complement C3 in gastrulation : a novel mechanism of ectoderm epiboly." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1456748/.

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The morphogenetic processes underlying gastrulation are driven through tightly localised cell rearrangements that occur in both ectodermal and mesodermal cells. While some of the cellular movement involved in the involution of the mesodermal cells have been studied in detail, and the movement of ectodermal cells have also been identified, we know very little about what regulates the movement of ectodermal cells during gastrulation. During gastrulation, the ectoderm suffers a dramatic expansion where an initial multilayered tissue becomes single-layered through a process called epiboly. During

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Tortelote, Giovane G. "An Extra-Embryonic Wnt Signaling Event Controls Gastrulation in Mice: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/643.

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The formation of the anterior-posterior axis requires a symmetry-breaking event that starts gastrulation. Ultimately, the morphogenetic movements of gastrulation reshape the embryo to its final tri-dimensional form. In mouse embryos, the identity of the molecule that breaks the bilateral symmetry and sets in motion gastrulation remains elusive. The Wnt signaling pathway plays a pivotal role during axial specification and gastrulation in metazoans. Loss-of-function experiments have demonstrated a requirement of Wnt3 for gastrulation in mice. But because Wnt3 is expressed sequentially in two tis

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Paduano, Vanessa. "Regulation of Myosin-II activation and planar polarity during epithelial morphogenesis in Drosophila embryo." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4102.

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Les épithéliums jouent le rôle de barrière physique et chimique chez les Métazoires. Les épithéliums subissent des remodelages pendant l’embryogénèse. La morphogénèse des tissus est dirigée par des déformations cellulaires coordonnées fonctionnant grâce à des réseaux contractiles intracellulaires constitués d’actine et de myosine. Ce réseau d’actomyosine peut être soit pulsatile, soit stable. Un exemple est l’élongation de l’ectoderme ventro-latéral par intercalation cellulaire, le long de l’axe antéro-postérieur (AP) de l’embryon de la Drosophile. Les jonctions parallèles à l’axe dorso-ventra

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Wang, Renee Wan-Jou 1979. "A comparative proteomic analysis of ectoderm and mesoderm in Xenopus laevis during gastrulation /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112317.

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During early development of Xenopus laevis, gastrulation is a key morphogenetic event which transforms the embryo into three of primary germ layers: ectoderm, mesoderm, and endoderm. In order for the physical separation of these layers to occur, cells have to acquire specific properties that distinguish one layer from another. These properties, which include cell adhesion and migration, should be reflected in the tissue-specific proteome. While genetic analysis has led to the determination of a number of proteins involved in germ layer formation, this method would not have identified those pro

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Gentsch, George Ernesto. "Chromatin biology of T-box transcription factors in Xenopus embryos during and beyond gastrulation." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610101.

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Hardy, Katharine. "Regulation of Avian Gastrulation by Fibroblast Growth Factor, Non-Canonical Wnt, and Eph-Ephrin Signaling Pathways." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195983.

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Gastrulation is a key early developmental event that generates the three primary germ layers (ectoderm, mesoderm, and endoderm) from which organ systems subsequently develop. The physical mechanisms of germ layer formation differ significantly in amniotes (reptiles, birds, and mammals) and anamniotes (e.g. frog and fish), as amniote gastrulation includes an epithelial-mesenchymal transition (EMT) that is absent from anamniote gastrulation. Despite this striking difference, much of our knowledge regarding the mechanisms underlying gastrulation is derived from frog and fish studies. To better un

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Carvalho, Lara. "The role of yolk syncytial layer and blastoderm movements during gastrulation in zebrafish." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1200566640735-93186.

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During gastrulation, a set of highly coordinated morphogenetic movements creates the shape and internal organization of the embryo. In teleostean fishes, these morphogenetic movements involve not only the embryonic progenitor cells (deep cells) but also two extra-embryonic tissues: an outer sheet of epithelial cells (EVL) and a yolk syncytial layer (YSL). Epiboly is characterized by the spreading of the blastoderm (deep cells and EVL) to cover the large yolk cell, whereas convergence and extension leads, respectively, to mediolateral narrowing and anteroposterior elongation of the embryo. Rece

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Munjal, Akankshi. "Regulation of a bio-mechanical network driving shape changes during tissue morphogenesis." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4038/document.

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Forces requises pour les changements de forme au cours de la morphogenèse des tissus sont générés par d’actine et de myosine. Durant ma thèse, je étudié le rôle de la réglementation MyoII par la voie Rho1-Rok durant l’élongation de l’ectoderme ventro-latéral par intercalation cellulaire. Les pulsations de MyoII médio-apicale se déplacent de manière anisotrope vers les jonctions parallèles avec l’axe dorso-ventral (ou jonctions verticales). Ceci provoque le rétrécissement graduel des jonctions qui sont stabilisées par une population de MyoII polarisée dans le plan du tissu et enrichie au niveau

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John, Alphy. "Propriétés subcellulaires et dynamique à l'échelle de l'embryon gouvernant la morphogenèse." Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://theses.univ-cotedazur.fr/2021COAZ6017.

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La morphogenèse est le processus de remodelage du zygote, la cellule œuf fécondée, qui permet d’obtenir la forme finale de l’animal. Chez l’embryon, les combinaisons de profils d’expression génique déterminent les axes de symétrie du corps et établissent les coordonnées spatiotemporelles de spécification des cellules. Ces profils affectent aussi l’organisation des composants du cytosquelette pour réguler la morphogenèse des tissus. Tandis qu’un travail important a été réalisé pour comprendre comment les motifs d’expression génique antéro-postérieur (AP) et dorso-ventral (DV) contrôlent indépen

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Cui, Cheng. "Dynamics of cell movement and tissue motion in gastrulation and micromass cell culture." [Bloomington, Ind.] : Indiana University, 2005. http://wwwlib.umi.com/dissertations/fullcit/3182618.

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Thesis (Ph.D.)--Indiana University, Dept. of Physics, 2005.<br>Source: Dissertation Abstracts International, Volume: 66-07, Section: B, page: 3594. Adviser: James A. Glazier. Title from dissertation home page (viewed Oct. 5, 2006).

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Sinner, Claude [Verfasser], and W. [Akademischer Betreuer] Wenzel. "Computational Insights into Zebrafish Brain Development during Gastrulation / Claude Sinner ; Betreuer: W. Wenzel." Karlsruhe : KIT-Bibliothek, 2017. http://d-nb.info/1129258831/34.

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Troilo, Helen. "The role of chordin and twisted gastrulation in regulating BMP family growth factors." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-chordin-and-twisted-gastrulation-in-regulating-bmp-family-growth-factors(d5e445cf-8ee3-4c33-869c-d548d84d5029).html.

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Bone morphogenetic proteins (BMPs) are growth factors of the TGF-β superfamily. They are essential to early embryonic patterning, and are of interest in a range of pathologies. The secreted glycoprotein chordin binds to BMPs and antagonizes their signalling by preventing them from interacting with their cell surface receptors. This antagonism is relieved by cleavage of chordin at two specific points by tolloid family metalloproteinases. Twisted gastrulation has a dual role in regulating this pathway. It binds to both chordin and BMPs strengthening their interaction but also promotes cleavage o

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Kennerley, Nicola. "Investigation of cell movement and the associated cytoskeleton during chick gastrulation and somitogenesis." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/48801/.

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Cell migration involves dynamic and spatially regulated changes to the cytoskeleton. During avian gastrulation, cells ingress through the primitive streak. Previous characterisation of microtubule organisation during this process revealed the distribution of cells with polarised and radial arrays across different regions of the embryo. Interestingly, many cells organised into groups arranged in rosette-like structures. As the primitive streak regresses and the neural folds gather at the centre of the embryo, bands of paraxial mesoderm that lie either side of the neural tube separate into somit

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Carvalho, Lara. "The role of yolk syncytial layer and blastoderm movements during gastrulation in zebrafish." Doctoral thesis, Technische Universität Dresden, 2007. https://tud.qucosa.de/id/qucosa%3A25041.

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During gastrulation, a set of highly coordinated morphogenetic movements creates the shape and internal organization of the embryo. In teleostean fishes, these morphogenetic movements involve not only the embryonic progenitor cells (deep cells) but also two extra-embryonic tissues: an outer sheet of epithelial cells (EVL) and a yolk syncytial layer (YSL). Epiboly is characterized by the spreading of the blastoderm (deep cells and EVL) to cover the large yolk cell, whereas convergence and extension leads, respectively, to mediolateral narrowing and anteroposterior elongation of the embryo. Rece

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Robin, François. "Contrôle moléculaire et cellulaire de la gastrulation chez un chordé, l'ascidie ciona intestinals." Aix-Marseille 2, 2009. http://www.theses.fr/2009AIX22008.

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Les évènements morphogénétiques qui façonnent l’embryon au cours du développement sont basés sur un répertoire limité de comportements cellulaires, tels que les changements de forme, les réarrangements cellulaires ou les divisions cellulaires. Les processus qui contrôlent plus spécifiquement la morphogenèse épithéliale, avec un grand nombre de cellules identiques, ont été très étudiés. Avec seulement une centaine de cellules au cours de la gastrulation, les Ascidies permettent d’étudier comment la morphogenèse cellulaire est contrôlée par des voies de signalisation et intégrée en morphogenèse

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ZAKIN, LISE. "Recherche des genes controles par l'homeogene otx2 pendant la gastrulation chez la souris." Paris 6, 1999. http://www.theses.fr/1999PA066532.

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La formation de la tete est un processus complexe, intervenant tot au cours de l'embryogenese. Les genes de la famille otx, qui codent pour des facteurs de transcription possedant une homeoboite, jouent precisement un role dans les mecanismes sous-jacents a la mise en place du systeme nerveux central. Le gene de drosophile orthodenticle (otd) est le premier membre de cette famille a avoir ete decouvert et sa mutation aboutit a la disparition totale de certains segments cephaliques. Depuis son identification chez drosophila melanogaster, deux genes homologues, otx1 et otx2, ont ete clones chez

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Gong, Ying Bronner-Fraser Marianne Fraser Scott E. "Cell polarity and morphogenesis : functions and mechanisms of cell divisions in vertebrate gastrulation /." Diss., Pasadena, Calif. : California Institute of Technology, 2004. http://resolver.caltech.edu/CaltechETD:etd-06052004-132200.

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