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Dissertations / Theses on the topic 'Genre synthesis in A'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Knopf, Michael David. "Style and Genre Synthesis in Music Composition: Revealing and Examining the Craft and Creative Processes in Composing Poly-Genre Music." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/366075.

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Enhancing new musical works by referencing style and genre is a well-established practice in music making around the world. Audiences and artists of the past century were particularly exposed to music of many styles and genres through the growth of information and knowledge transfer as a result of travel, various media and the Internet. This musical and cultural interaction was, as Nettl (1986, p. 371) characterized it, a “prevailing force in musical innovation.” Aubert (2000, p. 4) states that the “generalization all over the planet of the cultural hybridization process observed today is a ph

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2

Kong, David Sun 1979. "Microfluidic gene synthesis." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45755.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2008.<br>"June 2008."<br>Includes bibliographical references.<br>The ability to synthesize custom de novo DNA constructs rapidly, accurately, and inexpensively is highly desired by researchers, as synthetic genes and longer DNA constructs are enabling to numerous powerful applications in both traditional molecular biology and the emerging field of synthetic biology, from the synthesis of large sets of novel proteins to the complete re-writing of bacterial genomes. Ho

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3

Fernandes, Joana Pinto. "De novo gene synthesis." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7721.

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Mestrado em Biotecnologia Molecular<br>Due to the degeneracy of the genetic code, an average protein of 300 amino acids can be encoded by the truly astronomical number of more than 10150 different codon combinations; more than the estimated number of atoms in the observable universe. However, the choice between synonymous codons in the mRNA coding sequence is not random, but follows rules and has important functions in translation accuracy, efficiency and co-translational protein folding. This additional layer of information that mRNA primary structures encode is found in all three domains of

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4

Boufridi, Asmaa. "De l’étude d’éponges du genre Dactylospongia aux particularités chimiques des ilimaquinones." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114848/document.

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Notre équipe est l’un des partenaires du projet international PoMaRé (« Invertébrésbenthiques de Polynésie, Martinique et de la Réunion »). Nous travaillons encollaboration directe avec le Dr Cécile Debitus de l’IRD en Polynésie française, sonéquipe étant notamment en charge de collecter des échantillons d’éponges marinesdans différents atolls du Pacifique.Au laboratoire, nous nous sommes intéressés particulièrement à deux espècesabondantes en Polynésie : Dactylospongia metachromia et Dactylospongia elegans.Notre travail a consisté à isoler leurs métabolites spécialisés majoritaires : lesilima

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5

Segovia, Ugarte Romulo M. "Synthetic hypermutation : gene-drug mutation rate synergy reveals a translesion synthesis mechanism." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61269.

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Gene-gene or gene-drug interactions are typically quantified using fitness as a readout because the data is continuous and easily measured in high-throughput. However, to what extent fitness captures the range of other phenotypes that show synergistic effects is usually unknown. Using Saccharomyces cerevisiae, and focusing on a matrix of DNA repair mutants and genotoxic drugs, I quantified 76 gene-drug interactions based on both mutation rate and fitness and find that these parameters are not connected. Independent of fitness defects I identified seven cases of synthetic hypermutation, where t

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6

Kodo, Y. "Synthesis of oligonucleotides and genes." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233499.

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7

Yu, Zutao. "The design, synthesis and evaluation of synthetic transcription factors (Syn-TFs)." Kyoto University, 2018. http://hdl.handle.net/2433/235052.

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8

Storey, Benjamin 1973. "AQX : a novel gene in plant ubiquinone biosynthesis." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80882.

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C. elegans worms with mutations in the gene CLK-1 develop slowly and have an extended lifespan. CLK-1 encodes a mitochondrial protein that is responsible for the hydroxylation of 5-demethoxyubiquinone (DMQ), the penultimate step of ubiquinone (Coenzyme-Q or UQ) biosynthesis. Structural homologues of CLK-1 are found in mammals, fruit flies, yeast and some types of bacteria. Interestingly, however, there is no structural homologue of CLK-1 in the Arabidopsis genome and no plant homologue can be found in other sequence databases. Yeast with the CLK-1 homologue COQ7 deleted fail to grow on

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9

Wasser, Nicolas. "Synthèse et évaluation de l'activité anti-Leishmania d'anthranoïdes issus du genre Psorospermum (Hypericaceae) utilisé en médecine traditionnelle camerounaise." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF055/document.

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L’étude de plantes appartenant au genre Psorospermum, a conduit à isoler plusieurs composés anthranoïdes, dont 9 vismiones, à partir de l’extrait d’écorce de P. glaberrimum. Celles-ci ont montré de fortes activités anti-Leishmania. Afin de vérifier que l’activité anti-Leishmania des extraits est corrélée à leur teneur en vismiones, un dosage par LC-FTMS des vismiones dans plusieurs organes de différentes espèces de Psorospermum a été réalisé. Une approche par synthèse organique a permis 1) d’obtenir une large variété d’analogues de vismiones dans le but de mieux comprendre les déterminants str

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10

Bartoli, Alexandra. "Approche unifiée aux squelettes polycycliques de molécules isolées du genre Schisandra via une nouvelle réaction domino." Thesis, Aix-Marseille 3, 2011. http://www.theses.fr/2011AIX30023.

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Le système spirocyclique [6.4] est un motif récurrent dans un certain nombre de produits naturels tels que les Lancifodilactones, les Micrandilactones ou les Rubriflordilactones. Ces structures polycycliques représentent un défi synthétique pour les chimistes organiciens puisqu’elles présentent au moins neuf centres stéréogènes dont plusieurs sont quaternaires. L’objectif principal de ce travail était de développer de nouvelles réactions métallo-catalysées, et de les utiliser comme étape clé afin d’obtenir rapidement et efficacement le squelette polycyclique de ces composés. La première partie

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11

Horspool, Daniel Richard. "Gene synthesis by assembly of short oligonucleotides." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/16681.

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In principle, a pre-constructed library of all possible short oligonucleotides could be used to construct many distinct gene sequences. This approach requires computational methods to accurately determine the assembly procedure, but relieves the current technological constraints of custom oligonucleotide synthesis. In order to assess the feasibility of such an approach, I examined T4 DNA Ligase activity on short oligonucleotides and found that ligation is dependent on the formation of a double-stranded DNA duplex of at least five base pairs flanking the site of ligation. However, ligations c

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12

Chang, Thomas Kyu-Young Barton Jacqueline K. Gray Harry B. Richards John. "Gene synthesis, expression, and mutagenesis of azurin /." Diss., Pasadena, Calif. : California Institute of Technology, 1991. http://resolver.caltech.edu/CaltechETD:etd-06142007-132218.

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13

Abeßer, Jakob [Verfasser], Gerald [Akademischer Betreuer] Schuller, Meinard [Gutachter] Müller, and Anssi [Gutachter] Klapuri. "Automatic Transcription of Bass Guitar Tracks applied for Music Genre Classification and Sound Synthesis / Jakob Abeßer ; Gutachter: Meinard Müller, Anssi Klapuri ; Betreuer: Gerald Schuller." Ilmenau : TU Ilmenau, 2014. http://d-nb.info/1178180433/34.

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14

Abeßer, Jakob [Verfasser], Gerald [Akademischer Betreuer] Schuller, Meinard Gutachter] Müller, and Anssi [Gutachter] [Klapuri. "Automatic Transcription of Bass Guitar Tracks applied for Music Genre Classification and Sound Synthesis / Jakob Abeßer ; Gutachter: Meinard Müller, Anssi Klapuri ; Betreuer: Gerald Schuller." Ilmenau : TU Ilmenau, 2014. http://d-nb.info/1178180433/34.

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15

Park, Jason (Jason Sun-Hyung). "Synthesis and error correction methods in gene fabrication." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37961.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2006.<br>Includes bibliographical references (leaves 56-59).<br>Gene Fabrication technology involves the development and optimization of methods relevant to the in vitro synthesis of any given target gene sequence(s) in the absence of template. The driving purpose of this field of research is to bring about the capability for on-demand fabrication of a DNA construct of arbitrary length and sequence quickly, efficiently, and cost-effectively. The first part of this document describes many of the important

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16

Newcombe, Paul. "Bayesian evidence synthesis of gene-disease association studies." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536761.

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17

Bartoli, Alexandra. "Approche unifiée aux squelettes polycycliques de molécules isolées du genre Schisandra via une nouvelle réaction domino." Electronic Thesis or Diss., Aix-Marseille 3, 2011. http://www.theses.fr/2011AIX30023.

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Le système spirocyclique [6.4] est un motif récurrent dans un certain nombre de produits naturels tels que les Lancifodilactones, les Micrandilactones ou les Rubriflordilactones. Ces structures polycycliques représentent un défi synthétique pour les chimistes organiciens puisqu’elles présentent au moins neuf centres stéréogènes dont plusieurs sont quaternaires. L’objectif principal de ce travail était de développer de nouvelles réactions métallo-catalysées, et de les utiliser comme étape clé afin d’obtenir rapidement et efficacement le squelette polycyclique de ces composés. La première partie

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18

Sinclair, Steven J. "QPRTase : a wound-induced defence gene in Nicotiana." Monash University, School of Biological Sciences, 2003. http://arrow.monash.edu.au/hdl/1959.1/6571.

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19

Chang, Siu-Chi 1962. "Influence of manganese on amylase gene expression." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/291616.

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Previous studies have suggested that manganese (Mn) deficiency is associated with increased pancreatic amylase activity in rats. The present study investigated whether this increase in amylase activity is a result of increased pancreatic amylase messenger RNA (mRNA) levels. Weanling rats were fed a high carbohydrate diet containing either 39.6 ppm (control) or 0.5 ppm (deficient) manganese for 4 to 8 weeks. Manganese deficiency was confirmed by determining hepatic manganese content which was significantly lower in Mn-deficient rats than in the respective controls. Pancreatic RNA was size-fract

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20

Vousden, William Alexander. "Mutational analysis of the ACV synthetase gene of Aspergillus nidulans." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366097.

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21

Maginty, Amanda Bronagh. "Synthesis and evaluation of cationic lipids for gene delivery." Thesis, Queen's University Belfast, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727511.

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This thesis entails the synthesis and in vitro evaluation of a number of cationic lipids. These lipids include those with a dimethylamine (DMA) headgroup or trimethylamine (TMA) headgroup, a seven or eleven carbon chain length or a mixed carbon chain length within the hydrophobic domain. The lipids are characterised by acyclic or macrocyclic hydrophobic regions that are either saturated or unsaturated. The work describes the successful synthetic routes to these various different cationic lipids and looks at the biological effects that are had on toxicity, transfection and DNA binding, when the

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22

Currie, Suzanne. "Heat shock protein synthesis and gene expression in fish." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq22452.pdf.

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23

Ochocinska, Agata. "Synthesis towards 3-ribosyl amino acids, small gene probes." Thesis, University of Reading, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529972.

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24

Martin, Patricia E. M. "Control of protein synthesis by the reovirus S4 gene." Thesis, University of Warwick, 1991. http://wrap.warwick.ac.uk/108094/.

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Mammalian reoviruses have been used as a model to study the control of host cell protein synthesis following infection. The reovirus genome is composed of 10 segments of double stranded RNA each of which, with one exception, encodes a single protein. The three serotypes of the virus show marked differences in their effects on host cell protein synthesis following viral infection. Serotypes 2 and 3 give pronounced inhibition and serotype 1 has little effect. Genetic studies using intertypic reassortants have mapped this property to the S4 gene of the virus which encodes the major outer capsid p

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25

Hamilton, Andrew John. "Inhibiting gene expression with anti-sense RNA." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316938.

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26

Marshall, Jonathon J. A. "Regulation of insulin gene expression in rat islets of Langerhans." Thesis, University of Leicester, 1986. http://hdl.handle.net/2381/35103.

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The rate of glucose stimulated in vitro (pro)insulin synthesis in islets of Langerhans isolated from fed male rats was determined. Increases in the glucose concentration of the incubation medium, over the physiological range (2 to 20 mM), stimulated the rates of both (pro)insulin and total protein synthesis during a two hour incubation. This stimulation was preferential for (pro)insulin synthesis and had a sigmoidal dose response curve with a concentration threshold of between 2.5 mM and 5.0 mM and a maximal rate at 20 mM glucose. Inhibition of islet RNA synthesis by.;ctinomycin D depressedthe

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27

Ahmed, Md Salauddin. "Synthesis of Antimicrobial Polymers to Overcome Antimicrobial Resistance." FIU Digital Commons, 2017. https://digitalcommons.fiu.edu/etd/3692.

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Drug-resistant pathogens are emerging rapidly and thwart the treatment of common bacterial infectious diseases that can lead to death. Many contagious diseases remain difficult to treat because of acquired drug resistance. Compared to small antibiotics, which interrupt the intracellular biochemical processes, antimicrobial polymers with relatively high molecular weights offer a promising strategy to overcome drug resistance by disrupting the physical integrity of the membrane. Because of the unique mechanism, bacteria need a much longer time to develop resistance. A new class of antimicrobial

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28

Gibson, Fernando. "Characterisation of a factor required for specific gene expression during Dictyostelium development." Thesis, University of Leeds, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236330.

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29

Turing, J. D. "Aspects of the regulation of larval serum protein synthesis in Drosophila." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371588.

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30

Hickman, David Tadeusz. "Synthesis and binding studies of a pyrrolidine-amide nucleic acid mimic." Thesis, Birkbeck (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325541.

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31

Johansson, Henrik. "Gene regulation of UDP-glucose synthesis and metabolism in plants." Doctoral thesis, Umeå University, Plant Physiology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-93.

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<p>Photosynthesis captures light from the sun and converts it into carbohydrates, which are utilised by almost all living organisms. The conversion between the different forms of carbohydrates is the basis to form almost all biological molecules.</p><p>The main intention of this thesis has been to study the role of UDP-glucose in carbohydrate synthesis and metabolism, and in particular the genes that encode UDP-glucose pyrophosphorylase (UGPase) and UDP-glucose dehydrogenase (UGDH) in plants and their regulation. UGPase converts glucose-1-phosphate to UDP-glucose, which can be utilised for suc

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32

Waterhouse, Jodie Elizabeth. "Synthesis and application of integrin targeting lipopeptides in gene therapy." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405829.

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33

Getaz, Jayne Astrid. "Design, synthesis and evaluation of novel non-viral gene vectors." Thesis, Institute of Cancer Research (University Of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434909.

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34

Steiner, Paul Jamesen. "Oligonucleotide design and codon optimization for PCR-based gene synthesis." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/61292.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 79-80).<br>If synthetic biologists are to engineer novel biological functionality, they must be able to fabricate the DNA encoding it. A number of companies synthesize DNA for a fee, but their service is opaque. Researchers can alternatively perform their own syntheses, but the process is time-consuming and error-prone. This thesis introduces a software tool designed to make it simpler and more r

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35

van, der Aa Eveline Maria. "Synthesis and Characterization of Nucleobase-Containing Polyelectrolytes for Gene Delivery." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/33008.

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Wide literature precedence exists for polymers containing electrostatic interactions and polymers containing hydrogen bonding motifs, however the combination of electrostatic and hydrogen bonding interactions is not widely investigated in current literature. Polyelectrolytes containing hydrogen bonding groups are expected to exhibit properties of both classes of supramolecular interactions. A series of adenine- and thyminecontaining PDMAEMA and tert-butyl acrylate copolymers were synthesized to investigate the effect of incorporating hydrogen bonding groups into a polyelectrolyte. Incor

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36

Dréan, Mathilde. "Controlled synthesis of polyvinylamine-based (co)polymers for gene transfection." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066444.

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Le transfert de gènes consiste en l’introduction d’acides nucléiques au sein de cellules afin de modifier leur activité dans un but essentiellement thérapeutique. Pour préserver le matériel génétique de toute dégradation, il faut recourir à des vecteurs. Parmi ceux-ci, les polymères cationiques sont très prometteurs, en particulier, la polyéthylènimine, considérée comme le vecteur non-viral de référence. Néanmoins, il présente une cytotoxicité élevée. Ainsi, de nombreuses recherches ont pour but d’identifier et de développer de nouveaux polymères combinant efficacité de transfection et haute v

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37

Dréan, Mathilde. "Controlled synthesis of polyvinylamine-based (co)polymers for gene transfection." Electronic Thesis or Diss., Paris 6, 2016. http://www.theses.fr/2016PA066444.

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Le transfert de gènes consiste en l’introduction d’acides nucléiques au sein de cellules afin de modifier leur activité dans un but essentiellement thérapeutique. Pour préserver le matériel génétique de toute dégradation, il faut recourir à des vecteurs. Parmi ceux-ci, les polymères cationiques sont très prometteurs, en particulier, la polyéthylènimine, considérée comme le vecteur non-viral de référence. Néanmoins, il présente une cytotoxicité élevée. Ainsi, de nombreuses recherches ont pour but d’identifier et de développer de nouveaux polymères combinant efficacité de transfection et haute v

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38

Brown, Michael Dean. "Genetic analysis of RNA splicing in the thymidylate synthase gene of bacteriophage T4." Diss., Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/25390.

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39

Nicholl, Suzanne Maureen. "Neuropeptide Y receptor subtypes involved in the stimulation of ventricular cell hypertrophy and associated upregulation of gene expression." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343024.

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40

Norris, Richard. "An exploration of cross-genre composition focusing on the combination of natural and synthetic sound sources." Thesis, Royal Holloway, University of London, 2012. http://repository.royalholloway.ac.uk/items/2837960b-20e0-9ec8-dd40-ec05067f86de/11/.

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This portfolio explores a combination of acoustic performance with technology in various guises, including the use of backing tracks alongside an ensemble, the manipulation of live instruments with effects and the use of synthesizers and samplers along with an instrumental ensemble. A key feature that runs through the portfolio is the use of specific non-musical subject themes as inspiration for the music. These include the murders of five prostitutes in Ipswich in 2006 by Steve Wright, a speech by David Davis on people trafficking from 2005, the Mumbai hostage situation and bombings of 2007,

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41

Alqahtani, Abdulateef Alqarni. "Synthesis and Biological Evaluation of New HDAC Inhibitors." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525448898248748.

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42

Gokhale, S. A. "Mathematical modeling of gene expression system in Eukaryotes: form gene induction to protein synthesis." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2013. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/1923.

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43

Surinya, Katharina Helen. "Heme biosynthesis in erythroid cells : transcriptional egulation of the human 5=aminolevulinate synthase 2 gene /." Title page, contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phs961.pdf.

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44

Healy, Helen Moira. "Studies on the regulation of the human hepatic 5-aminolevulinate synthase gene /." Title page, contents and introduction only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09phh4325.pdf.

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45

Li, Ping, and 李平. "Analysis and synthesis of positive systems and related gene network models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46587020.

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The Best PhD Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize,2010-11<br>published_or_final_version<br>Mechanical Engineering<br>Doctoral<br>Doctor of Philosophy

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46

Thomas, Spencer Angus. "Synthesis, analysis and reconstruction of gene regulatory networks using evolutionary algorithms." Thesis, University of Surrey, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.659110.

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Large and complex biological networks are thought to be built from small functional modules called motifs. Currently there has been insufficient study of the fundamental understanding of these motifs which has resulted in a lack of consensus of their role and presence in biology. Here we investigate two networks that produce biologically important dynamics, an oscillation and a toggle switch. We couple these motifs and observe multiple sets of combined dynamic behaviour and evidence of 'gene connectivity preferences between the two networks. Such fundamental studies of networks can be performe

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47

Brownlie, Anthony. "The synthesis and characterisation of modified polyethylenimine polymers for gene delivery." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248766.

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48

Zugates, Gregory Thomas. "Synthesis and chemical modification of degradable polymers to enhance gene delivery." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/38970.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, February 2007.<br>Includes bibliographical references.<br>Poly([beta]-amino ester)s are a class of cationic, degradable polymers that have shown significant promise as gene delivery agents, more effective than the state-of-the-art, commercially available non-viral systems. The main objective of this thesis is to synthesize new poly([beta]-amino ester)s and modify existing ones to further improve their gene delivery properties for clinical applications. This has been accomplished by developing both side- and

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49

Ho, J. K. W. "Synthesis and biophysical studies of cationic lipids as gene delivery vectors." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1389331/.

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Non–viral gene vectors exhibit several desirable properties, over their viral counterparts. This has generated vast interest in the development of efficient non–viral vectors for DNA in gene therapy. The first generation lipid/peptide/DNA (LID) vector was comprised of Lipofectin™, a 1:1 mixture of DOTMA and DOPE, together with a targeting peptide. The resulting LID vector exhibited significant advantages over cationic liposome vectors (lipoplex systems) for gene delivery, transfecting a range of cells with high transfection efficiencies. The LID vector is introduced, and its advantages are out

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50

Thoendel, Matthew James. "Synthesis of the accessory gene regulator autoinducing peptide in Staphylococcus aureus." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2999.

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The accessory gene regulator (agr) quorum-sensing system is one of the major regulators of virulence factor production in the pathogen Staphylococcus aureus. Activation of the system depends on the production and sensing of a cyclic peptide signal called the autoinducing peptide (AIP). The biosynthesis of AIP depends on the coordinated action of the AgrB integral membrane endopeptidase and SpsB signal peptidase to process the peptide precursor AgrD into the final signal structure. The primary goal of this dissertation was

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