Academic literature on the topic 'Glomerular basement membrane'

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Journal articles on the topic "Glomerular basement membrane"

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Cortes, P., X. Zhao, F. Dumler, B. C. Tilley, and J. Atherton. "Age-related changes in glomerular volume and hydroxyproline content in rat and human." Journal of the American Society of Nephrology 2, no. 12 (1992): 1716–25. http://dx.doi.org/10.1681/asn.v2121716.

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Total 4-hydroxyproline content and volume were measured in the same sample of microdissected glomeruli obtained fro rat and human outer or inner cortex. Glomerular volume was determined by computer-assisted image analysis, and 4-hydroxyproline was measured by a highly sensitive gas-liquid chromatographic method. Results were expressed as weight of basement membrane material by comparison with the amount of 4-hydroxyproline in purified basement membrane/mesangial matrix preparations. Microanalyses were possible in samples containing as few as eight human glomeruli. Rat glomerular size increased
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Ogura, A., H. Fujimura, T. Asano, M. Koura, I. Naito, and Y. Kobayashi. "Early Ultrastructural Glomerular Alterations in Neonatal Nephrotic Mice (ICGN Strain)." Veterinary Pathology 32, no. 3 (1995): 321–23. http://dx.doi.org/10.1177/030098589503200317.

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ICGN is a strain of mice with hereditary nephrotic syndrome of an unknown cause. In this study, early glomerular alterations in newborn ICGN mice were observed with electron microscopy to gain a better insight into the onset of the disease. Development of the glomeruli was normal until fusion of epithelial and endothelial basement membranes in the developing capillary stage. From the maturing glomerulus stage onward, the fused glomerular basement membrane (GBM) increased in thickness by excessive accumulation of the basement membrane material secreted from the epithelial cells. This accumulati
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Desjardins, M., and M. Bendayan. "Ontogenesis of glomerular basement membrane: structural and functional properties." Journal of Cell Biology 113, no. 3 (1991): 689–700. http://dx.doi.org/10.1083/jcb.113.3.689.

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Protein A-gold immunocytochemistry was applied in combination with morphometrical approaches to reveal the alpha 1(IV), alpha 2(IV), and alpha 3(IV) chains of type IV collagen as well as entactin on renal basement membranes, particularly on the glomerular one, during maturation. The results have indicated that a heterogeneity between renal basement membranes appears during the maturation process. In the glomerulus at the capillary loop stage, both the epithelial and endothelial cell basement membranes were labeled for the alpha 1(IV) and alpha 2(IV) chains of type IV collagen and entactin. Aft
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Comper, W. D., A. S. N. Lee, M. Tay, and Y. Adal. "Anionic charge concentration of rat kidney glomeruli and glomerular basement membrane." Biochemical Journal 289, no. 3 (1993): 647–52. http://dx.doi.org/10.1042/bj2890647.

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Estimates of levels of glomerular and glomerular-basement-membrane anion charge should serve as useful quantitative markers for the integrity of the tissues in health and disease. We have developed a simple, rapid, technique to measure this charge through the use of ion exchange with radioisotopes 22Na+ and 36Cl- at low ionic strengths in phosphate buffer. When this technique is used, normal glomeruli isolated from rat have a measured net anion charge concentration of 17.4 +/- 3.7 p-equiv. per glomerulus (n = 20). Perfused rat kidneys that lose approximately half of their glomerular heparan [3
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Gunwar, Sripad, Fernando Ballester, Milton E. Noelken, Yoshikazu Sado, Yoshifumi Ninomiya, and Billy G. Hudson. "Glomerular Basement Membrane." Journal of Biological Chemistry 273, no. 15 (1998): 8767–75. http://dx.doi.org/10.1074/jbc.273.15.8767.

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McCarthy, K. J., K. Bynum, P. L. St John, D. R. Abrahamson, and J. R. Couchman. "Basement membrane proteoglycans in glomerular morphogenesis: chondroitin sulfate proteoglycan is temporally and spatially restricted during development." Journal of Histochemistry & Cytochemistry 41, no. 3 (1993): 401–14. http://dx.doi.org/10.1177/41.3.8429203.

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We previously reported the presence of a basement membrane-specific chondroitin sulfate proteoglycan (BM-CSPG) in basement membranes of almost all adult tissues. However, an exception to this ubiquitous distribution was found in the kidney, where BM-CSPG was absent from the glomerular capillary basement membrane (GBM) but present in other basement membranes of the nephron, including collecting ducts, tubules, Bowman's capsule, and the glomerular mesangium. In light of this unique pattern of distribution and of the complex histoarchitectural reorganization occurring during nephrogenesis, the pr
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Dakovic-Bjelakovic, Marija, Vojin Savic, Slobodan Vlajkovic, and Tanja Dzopalic. "Development and ultrastructure of glomerular capillaries in human foetus." Srpski arhiv za celokupno lekarstvo 136, Suppl. 4 (2008): 316–22. http://dx.doi.org/10.2298/sarh08s4316d.

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Glomerulus is an important filtrating apparatus in the body. Three types of cells - endothelial, mesangial and visceral epithelial cells can be identified in the capillary tuft. Glomeruli develop during nephrogenesis which starts in the 8th week and ends between the 32nd and 36th week of gestation. The nephron develops through stages described as the vesicle, the comma-shaped, S-shaped with the developing glomerulus and the mature glomerulus. Glomerular differentiation involves the expansion of the original capillary component into the plexus that consists of 6-8 loops and the migration of pod
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Beavan, L. A., M. Davies, and R. M. Mason. "Renal glomerular proteoglycans. An investigation of their synthesis in vivo using a technique for fixation in situ." Biochemical Journal 251, no. 2 (1988): 411–18. http://dx.doi.org/10.1042/bj2510411.

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Newly synthesized rat glomerular [35S]proteoglycans were labelled in vivo after injecting Na2[35S]SO4 intraperitoneally. At the end of the labelling period (7 h) the kidneys were perfused in situ with 0.01% (w/v) cetylpyridinium chloride. This fixed proteoglycans in the tissue and increased their recovery 2-3-fold during subsequent isolation of glomeruli from the renal cortex. The glomeruli were fractionated by a modified osmotic lysis and detergent extraction procedure [Meezan, Brendel, Hjelle & Carlson (1978) in The Biology and Chemistry of Basement Membranes (Kefalides, N.A., ed.), Acad
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Thompson, C. H., and S. Kalowski. "Anti-Glomerular Basement Membrane." Nephron 58, no. 2 (1991): 238–39. http://dx.doi.org/10.1159/000186424.

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Miner, Jeffrey H. "The glomerular basement membrane." Experimental Cell Research 318, no. 9 (2012): 973–78. http://dx.doi.org/10.1016/j.yexcr.2012.02.031.

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Dissertations / Theses on the topic "Glomerular basement membrane"

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Wootton, Andrew. "The glomerular basement membrane and nephritis /." Title page, contents and abstract only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phw918.pdf.

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Walton, H. A. "The effect of structural modifications on the permeation properties of renal basement membrane." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382711.

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Falcone, Sara. "Nephrotic syndrome and glomerular basement membrane : genetic defect of the laminin α5 chain". Thesis, Open University, 2018. http://oro.open.ac.uk/56060/.

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Nephrotic syndrome is a heterogeneous group of disorders characterised by renal and extra-renal manifestations. Classic symptoms of nephrotic syndrome include severe proteinuria, hypoalbumiaemia, oedema and hyperlipidaemia. Genetic studies of hereditary forms of nephrotic syndrome have led to the identification of proteins playing a crucial role in slit diaphragm signalling, regulation of actin cytoskeleton dynamics and cell-matrix interactions. The laminin α5 chain is a 404 kDa protein essential for embryonic development and, in association with laminin β2 and laminin γ1, it is a major compon
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Leow, Chon Kar. "The long-term metabolic function of pancreatic islet grafts and the effect on glomerular basement membrane thickness." Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358194.

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Cox, Melissa Luanne. "Identification of a mutation in COL4A5 causative for X-linked Alport syndrome in the domestic dog and analysis of gene expression in the kidneys of affected and nonaffected siblings." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/244.

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The domestic dog, Canis lupus familiaris, plays many roles in the lives of humans. Additionally, the dog is recognized for its potential as a model for many human hereditary diseases. Thus, the genetics and genomics of the dog are being studied extensively in order to facilitate its use as a model, as well as to help the dog for its own sake. As part of this research effort, our laboratory has added type I markers (i.e., the acidic and basic keratins, c-kit, type I and IV collagens, and the gene encoding uromodulin) to the emerging map of the canine genome. The mapping of genes, particularly t
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Toda, Naohiro. "Crucial Role of Mesangial Cell-derived Connective Tissue Growth Factor in a Mouse Model of Anti-Glomerular Basement Membrane Glomerulonephritis." Kyoto University, 2018. http://hdl.handle.net/2433/232131.

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Dessapt, Cecile. "Regulation of alpha3beta1 integrin expression in podocytes by mechanical stretch, TGFbeta1 and glucose : implication for podocyte detachment from the glomerular basement membrane." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437750.

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Kawamura, Takahide. "Ultrastructural localization of dominantly increased fibronectin in the markedly thickend glomerular basement membrane in selectively mated murine high IgA strain(HIGA mice)." Kyoto University, 2001. http://hdl.handle.net/2433/150201.

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Cornet, Sylvie. "Evolution de la lame basale glomerulaire au cours de la nephrogenese et de la senescence, chez le rat." Paris 6, 1988. http://www.theses.fr/1988PA066166.

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Bolton, Glen R. (Glen Reed) 1970. "Permeation of ficoll and ficoll sulfate through glomeruler basement membrane : effects of molecular size and charge." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50390.

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Books on the topic "Glomerular basement membrane"

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International Symposium on Glomerular Basement Membrane (2nd 1983 Vienna, Austria). Glomerular basement membrane: Contributions to the 2nd International Symposium on Glomerular Basement Membrane, Vienna, September 1983. Edited by Hudson Billy G and Lubec Gert. Libbey, 1985.

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International Symposium on Glomerular Basement Membrane (2nd 1983 Vienna). Glomerular basement membrane: Contributions to the 2nd International Symposium on Glomerular Basement Membrane, Vienna, September 1983. Edited by Lubec Gert and Hudson Billy G. Libbey, 1985.

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Membranes, International Symposium on Renal Basement. Progress in basement membrane research: Renal and related aspects in health and disease : proceedings. J. Libbey, 1988.

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Lennon, Rachel, and Neil Turner. The molecular basis of glomerular basement membrane disorders. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0320_update_001.

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The glomerular basement membrane (GBM) is a condensed network of extracellular matrix molecules which provides a scaffold and niche to support the function of the overlying glomerular cells. Within the glomerulus, the GBM separates the fenestrated endothelial cells, which line capillary walls from the epithelial cells or podocytes, which cover the outer aspect of the capillaries. In common with basement membranes throughout the body, the GBM contains core components including collagen IV, laminins, nidogens, and heparan sulphate proteoglycans. However, specific isoforms of these proteins are r
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Heidet, Laurence, Bertrand Knebelmann, and Marie Claire Gubler. Thin glomerular basement membrane nephropathy and other collagenopathies. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0325_update_001.

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The discovery of a thin glomerular basement membrane in a renal biopsy without any other abnormalities can be explained in a number of ways. This could be an early biopsy in a patient with Alport syndrome, or it could be an individual who is a carrier for an Alport gene. These carriers are at increased risk of significant renal disease in their lifetime and some have proteinuria as well as haematuria, so they can no longer be equated with the historic label of benign familial haematuria. Some families with a thin glomerular basement membrane and haematuria inherited in an autosomal dominant fa
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Cui, Zhao, Neil Turner, and Ming-hui Zhao. Antiglomerular basement membrane disease. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0071.

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Antiglomerular basement membrane disease is characteristically the most rapidly progressive (crescentic) nephritis. It is often accompanied by lung haemorrhage, and occasionally causes lung disease alone. Its hallmark is linear deposition of immunoglobulin G along the glomerular basement membrane. There are usually few systemic symptoms apart from any related to the lung disease. Urine shows haematuria, often macroscopic in very acute disease.
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Cui, Zhao, Neil Turner, and Ming-hui Zhao. Antiglomerular basement membrane disease. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0073_update_001.

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Cyclophosphamide and plasma exchange are the standard of care in rapidly progressive glomerulonephritis or lung haemorrhage caused by antiglomerular basement membrane (anti-GBM) disease, and it is unusual to encounter patients at earlier stages. Steroids are universally used in addition. There is some evidence that plasma exchange may not be a critical part of treatment at an earlier stage. There is no more than anecdotal evidence for other therapies. Slower-onset therapies such as antibodies to B cells are rarely appropriate. If untreated, patients with severe anti-GBM disease will not recove
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Cui, Zhao, Neil Turner, and Ming-hui Zhao. Alport post-transplant antiglomerular basement membrane disease. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0075.

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Alport antiglomerular basement membrane (anti-GBM) disease is a rare example of disease caused by allo-sensitization after renal transplantation, first described in 1992. Because the recipient lacks a specific glomerular basement membrane (GBM) protein, they can become sensitized to the normal molecule present in the GBM of the donor kidney. The disease is restricted to the allograft. Interestingly severe disease arises from this only arises rarely, certainly less than 1 in 20, probably closer to 1 in 50. It characteristically causes late graft loss in a first transplant with accelerated tempo
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Turner, Neil. Mechanisms of glomerular injury. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0045.

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Proteinuric diseases, historically termed ‘nephrosis’, are characterized by subtle abnormalities in podocytes or by abnormal glomerular matrix, including the scarring laid down by inflammatory diseases. Angiotensin blockers, corticosteroids, calcineurin inhibitors, and a wide range of other drugs known or believed to be effective in different renal diseases, appear to have direct effects on podocytes that reduce proteinuria that may be important to their effectiveness. Several of these have previously been assumed to work via haemodynamic, immune or other modes. Haematuric diseases are charact
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Elger, Marlies, and Wilhelm Kriz. The renal glomerulus. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0043.

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The glomerulus performs its functions with three major cell types. Endothelial cells and visceral epithelial cells (podocytes) lie on the inside and outside of the glomerular basement membrane, and together these three structures form the glomerular filtration barrier. Mesangial cells sit in the axial region. Pathologies of all these regions and cell types can be identified. Parietal epithelial cells lining Bowman’s capsule participate in crescent formation, and at the tubular pole some of these cells seem to represent a stem cell population for tubular cells and podocytes. The extraglomerular
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Book chapters on the topic "Glomerular basement membrane"

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Pavelka, Margit, and Jürgen Roth. "Glomerular Basement Membrane." In Functional Ultrastructure. Springer Vienna, 2010. http://dx.doi.org/10.1007/978-3-211-99390-3_95.

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Benchimol, Corinne. "Anti-glomerular Basement Membrane Disease." In Glomerulonephritis. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-49379-4_19.

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Rossini, Michele, Annamaria Di Palma, Vito Racanelli, Francesco Dammacco, and Loreto Gesualdo. "Anti-Glomerular Basement Membrane Disease." In Systemic Vasculitides: Current Status and Perspectives. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40136-2_17.

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McAdoo, Stephen P., and Charles D. Pusey. "Anti-glomerular Basement Membrane Disease." In Encyclopedia of Medical Immunology. Springer New York, 2014. http://dx.doi.org/10.1007/978-0-387-84828-0_53.

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Turner, N., and C. D. Pusey. "Anti-glomerular Basement Membrane Disease." In Immunology of Renal Disease. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3902-1_11.

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Salama, Alan D. "Anti-glomerular Basement Membrane Disease." In Core Concepts in Parenchymal Kidney Disease. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8166-9_9.

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Gupta, Pallav, and Ramesh K. Gupta. "Alport’s Syndrome and Thin Basement Membrane Disease." In Pathology of Glomerular Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-1430-0_9.

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Champion, Howard R., Nova L. Panebianco, Jan J. De Waele, et al. "Anti-glomerular Basement Membrane (GBM) Disease." In Encyclopedia of Intensive Care Medicine. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_1133.

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Kashtan, Clifford E., and Alfred F. Michael. "Immunogenetics of the Glomerular Basement Membrane." In Inheritance of Kidney and Urinary Tract Diseases. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-1603-9_4.

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Turner, A. Neil, and Eleri Williams. "Genetic Disorders of the Glomerular Basement Membrane." In Practical Nephrology. Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-5547-8_43.

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Conference papers on the topic "Glomerular basement membrane"

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Tossin, Gabriel Pereira, Isabela Bulhões Faganello, Sthefanny Josephine Klein Otton Guedes, et al. "GRANULOMATOSIS WITH POLYANGIITIS ASSOCIATED TO ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE." In XXXIX Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2022. http://dx.doi.org/10.47660/cbr.2022.2193.

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Fernandez, C. J., and S. Saha. "A Rare Presentation of Atypical Anti-Glomerular Basement Membrane Disease." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1468.

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Ong, Sim Heng, S. T. Giam, X. Jayasooriah, and R. Sinniah. "Semiautomated detection and measurement of glomerular basement membrane from electron micrographs." In Medical Imaging V: Image Processing, edited by Murray H. Loew. SPIE, 1991. http://dx.doi.org/10.1117/12.45253.

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Josephson, Maureen B., and Ronald C. Rubenstein. "Anti-Glomerular Basement Membrane Antibody In An Infant with Pulmonary Hemosiderosis." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6209.

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Karca, A., Z. J. Gandhi, I. Ahmad, and S. Naik. "Early Recognition of Anti-Glomerular Basement Membrane Disease Can Be Lifesaving!" In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5792.

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Azeloglu, Evren U., Mark Stothers, Thomas J. Deerinck, et al. "3-D Quantitative Microanatomy of Rat Kidney Podocytes as Determined by Serial Block-Face Scanning Electron Microscopy." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80650.

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The shape of a cell is critical for proper signaling and resultant biological function [1]. Podocytes, kidney visceral epithelial cells, have a distinctive morphology with interdigitating foot processes that wrap around the capillaries of the glomeruli and, together with endothelial cells and the basement membrane, form the glomerular filtration barrier. In addition to forming the filtration barrier, slit diaphragms that connect the alternating foot processes from two podocytes are thought to be signaling hubs that regulate cell morphology and function.
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Rangayyan, R. M., I. Kamenetsky, and H. Benediktsson. "Segmentation and analysis of the glomerular basement membrane using active contour models." In 4th IET International Conference on Advances in Medical, Signal and Information Processing (MEDSIP 2008). IEE, 2008. http://dx.doi.org/10.1049/cp:20080442.

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Cracco, Luiz Augusto Fanhani, Marian Hanae Oda, Gustavo Koíti Kondo, et al. "ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE (GOODPASTURE SYNDROME) COMMONLY REMEMBERED BUT RARELY SEEN." In XL Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2023. http://dx.doi.org/10.47660/cbr.2023.1974.

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Martens, A. M., J. Shah, and B. A. Nelson. "Anti-Glomerular Basement Membrane Disease in a Pediatric Patient with Dyspnea and Cough." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3277.

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Kamenetsky, Ilya, Rangaraj M. Rangayyan, and Hallgrimur Benediktsson. "Segmentation and analysis of the glomerular basement membrane using the split and merge method." In 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2008. http://dx.doi.org/10.1109/iembs.2008.4649850.

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