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Journal articles on the topic 'HDV infection'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Oberhardt, Valerie, Maike Hofmann, Robert Thimme, and Christoph Neumann-Haefelin. "Adaptive Immune Responses, Immune Escape and Immune-Mediated Pathogenesis during HDV Infection." Viruses 14, no. 2 (2022): 198. http://dx.doi.org/10.3390/v14020198.

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The hepatitis delta virus (HDV) is the smallest known human virus, yet it causes great harm to patients co-infected with hepatitis B virus (HBV). As a satellite virus of HBV, HDV requires the surface antigen of HBV (HBsAg) for sufficient viral packaging and spread. The special circumstance of co-infection, albeit only one partner depends on the other, raises many virological, immunological, and pathophysiological questions. In the last years, breakthroughs were made in understanding the adaptive immune response, in particular, virus-specific CD4+ and CD8+ T cells, in self-limited versus persis

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Troisi, CL, FB Hollinger, WK Hoots, et al. "A multicenter study of viral hepatitis in a United States hemophilic population." Blood 81, no. 2 (1993): 412–18. http://dx.doi.org/10.1182/blood.v81.2.412.412.

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Abstract Hemophilia A and B patients seen at nine US regional treatment centers were tested for serologic markers of hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV) during 1987 and 1988. Because human immunodeficiency virus (HIV) infection, a potentially confounding variable, was present in 53% of the group, the population was divided by HIV status for analysis purposes. In the HIV-positive group (N = 382), less than 1% had not been infected with HBV, HCV, or HDV, whereas 75% had evidence of infection with HBV and 98% with HCV. HBsAg, a marker of active HBV in

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Troisi, CL, FB Hollinger, WK Hoots, et al. "A multicenter study of viral hepatitis in a United States hemophilic population." Blood 81, no. 2 (1993): 412–18. http://dx.doi.org/10.1182/blood.v81.2.412.bloodjournal812412.

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Hemophilia A and B patients seen at nine US regional treatment centers were tested for serologic markers of hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV) during 1987 and 1988. Because human immunodeficiency virus (HIV) infection, a potentially confounding variable, was present in 53% of the group, the population was divided by HIV status for analysis purposes. In the HIV-positive group (N = 382), less than 1% had not been infected with HBV, HCV, or HDV, whereas 75% had evidence of infection with HBV and 98% with HCV. HBsAg, a marker of active HBV infection,

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Jargalsaikhan, Orgil, Wenhua Shao, Mayuko Ichimura-Shimizu, et al. "Histopathological Features of Hepatocellular Carcinoma in Patients with Hepatitis B and D Virus Infection: A Single-Institution Study in Mongolia." Cancers 17, no. 3 (2025): 432. https://doi.org/10.3390/cancers17030432.

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Background: Viral hepatitis, particularly hepatitis B (HBV) and hepatitis C (HCV), is highly prevalent in Mongolia. Moreover, Mongolia has the highest prevalence of hepatitis delta virus (HDV) globally, with over 60% of HBV-infected individuals also co-infected with HDV. Since HBV/HDV infections accelerate liver disease progression more compared to HBV infection alone, urgent national health measures are required. Method: This study presents a clinicopathological analysis of 49 hepatocellular carcinoma cases surgically resected at the Mongolia–Japan Hospital of the Mongolian National Universit

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Roggenbach, Imme, Xiumei Chi, Florian A. Lempp, et al. "HDV Seroprevalence in HBsAg-Positive Patients in China Occurs in Hotspots and Is Not Associated with HCV Mono-Infection." Viruses 13, no. 9 (2021): 1799. http://dx.doi.org/10.3390/v13091799.

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HDV infection causes severe liver disease, the global health burden of which may be underestimated due to limited epidemiological data. HDV depends on HBV for infection, but recent studies indicated that dissemination can also be supported by other helper viruses such as HCV. We used a rapid point-of-care test and an ELISA to retrospectively test for antibodies against the Hepatitis Delta antigen (anti-HDV-Ab) in 4103 HBsAg-positive and 1661 HBsAg-negative, anti-HCV-positive sera from China and Germany. We found that the HDV seroprevalence in HBsAg-positive patients in China is limited to geog

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Takahashi, Masaharu, Tsutomu Nishizawa, Yuhko Gotanda, et al. "High Prevalence of Antibodies to Hepatitis A and E Viruses and Viremia of Hepatitis B, C, and D Viruses among Apparently Healthy Populations in Mongolia." Clinical Diagnostic Laboratory Immunology 11, no. 2 (2004): 392–98. http://dx.doi.org/10.1128/cdli.11.2.392-398.2004.

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ABSTRACT The prevalence of infection with hepatitis A virus (HAV), HBV, HCV, HDV, and HEV was evaluated in 249 apparently healthy individuals, including 122 inhabitants in Ulaanbaatar, the capital city of Mongolia, and 127 age- and sex-matched members of nomadic tribes who lived around the capital city. Overall, hepatitis B surface antigen (HBsAg) was detected in 24 subjects (10%), of whom 22 (92%) had detectable HBV DNA. Surprisingly, HDV RNA was detectable in 20 (83%) of the 24 HBsAg-positive subjects. HCV-associated antibodies were detected in 41 (16%) and HCV RNA was detected in 36 (14%) s

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Ziaee, Masood, Roghiya Azizee, and Mohammad Hasan Namaei. "Prevalence of HCV Infection in Hemodialysis Patients of South Khorasan in Comparison With HBV, HDV, HTLV I/II, And HIV Infection." Bangladesh Journal of Medical Science 13, no. 1 (2013): 36–39. http://dx.doi.org/10.3329/bjms.v13i1.13903.

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Background and objective: This study was performed to evaluate the prevalence of Hepatitis C virus (HCV) infection as well as HBV, HDV, HTLV I/II, and HIV infection in hemodialysis patients in our district. Methods: The subjects of this study involved 41 hemodialysis patients admitted to hemodialysis ward, Vali- Asr hospital. HBV, HDV, HIV, and HTLV1/2 infections were evaluated by enzyme-linked immunosorbent assay (ELISA) technique. Serum anti- HCV anti-body was measured using the 3rd generation of ELISA kit. HCV Viremia was evaluated in all patients using RT-PCR technique. Results: HCV infect

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Udosen, Joseph E., Euphoria C. Akwiwu, Dennis A. Abunimye, Utibe-Abasi Felix, David U. Akpotuzor, and Josephine O. Akpotuzor. "Prevalence of Hepatitis B, C and D Infections in Preoperative Patients at a Tertiary Hospital in Southern Nigeria." Sokoto Journal of Medical Laboratory Science 8, no. 1 (2023): 40–43. http://dx.doi.org/10.4314/sokjmls.v8i1.5.

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Patients going for surgical operations are required to be screened for hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among other transmissible infections. This is necessary for better assessment of the patient's condition alongside the need for extra precautions during surgery. Hepatitis D virus (HDV) infection is not commonly reported but occurs in association with commonly reported but occurs in association with that of hepatitis B virus. The epidemiology of this co-infection is worth investigating, as it constitutes a more aggressive form of hepatitis Following due ethical

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Gheorghe, Liana, Irma Eva Csiki, Speranta Iacob, et al. "Hepatitis Delta Virus Infection in Romania: Prevalence and Risk Factors." Journal of Gastrointestinal and Liver Diseases 24, no. 4 (2015): 413–21. http://dx.doi.org/10.15403/jgld.2014.1121.244.dtv.

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Background: Hepatitis delta virus (HDV) infection is associated with accelerated progression of fibrosis, early occurrence of hepatic decompensation and an increased risk for hepatocellular carcinoma. Epidemiological data on hepatitis delta virus (HDV) in Romania are still lacking. Aim: To assess the prevalence, virological, clinical and epidemiological features of HDV infection in Romanian patients. Methods: We conducted a multicenter study in 10 centers. Data on sociodemographic characteristics and potential risk factors were collected through a questionnaire. Virological markers of HB

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Chu, Chia-Ming, Chau-Ting Yeh, and Yun-Fan Liaw. "Low-Level Viremia and Intracellular Expression of Hepatitis B Surface Antigen (HBsAg) in HBsAg Carriers with Concurrent Hepatitis C Virus Infection." Journal of Clinical Microbiology 36, no. 7 (1998): 2084–86. http://dx.doi.org/10.1128/jcm.36.7.2084-2086.1998.

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Assays of hepatitis B virus (HBV) replication and antigen expression in HBV surface antigen (HBsAg) carriers with concurrent hepatitis C or D virus (HCV or HDV) infection revealed that HCV and HDV can suppress HBV replication but that HCV also substantially suppresses HBV surface protein expression. HBsAg carriers with concurrent HCV infection thus have low-level viremia and intracellular HBsAg.

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Curici, Antoanela, Olivia Mioara Ilie, and Dana Elena Mindru. "Prevalence of HDV, HCV, and HIV Infection in the Population of Patients Infected with HBV in a Romanian Cohort." Microorganisms 13, no. 1 (2025): 118. https://doi.org/10.3390/microorganisms13010118.

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Hepatitis B virus (HBV) infections remain a significant global health challenge, especially in low- and middle-income countries where access to healthcare services is often limited. This study aimed to assess the prevalence of hepatitis B virus (HBV), hepatitis delta virus (HDV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) co-infections in a cohort of 426,528 patients tested for HBsAg in Romania between 2018 and 2023. Of the 17,082 HBsAg-positive individuals (4.0% prevalence), the highest HBV positivity rates were observed in the 30–39 and over 60 age groups. Chronic HBV in

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Balta, Alexia Anastasia Stefania, Mariana Daniela Ignat, Raisa Eloise Barbu, et al. "HBV, HCV, and HDV Triple-Infection—A Therapeutic Challenge." Diseases 13, no. 6 (2025): 168. https://doi.org/10.3390/diseases13060168.

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Purpose: This article aims to harmonize the current data from the literature, describe baseline severity, and discuss potential treatment considerations for cases of triple infection. Patients and Methods: We undertook a retrospective, observational study on 1244 patients with viral hepatitis study subgroups: chronic replicative hepatitis with HCV—679 patients, HBV—98 patients, HBV/HCV—25 patients, HBV/HDV—14 patients, and 2 patients with triple-infection (HBV, HCV, and HDV), hospitalized in the Second Department of “Sf. Cuv. Parascheva” Infectious Diseases Clinical Hospital of Galați, Romania

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Dr, Qurat ul Ain Asghar Dr Ateeb Parvez Dr Rao Tayyaba Noor. "A DESCRIPTIVE STUDY ON PREVALENCE, PATTERN AND COINFECTION OF HEPATITIS VIRUSES IN ACUTE INFECTIOUS HEPATITIS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 9603–8. https://doi.org/10.5281/zenodo.2859406.

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<strong><em>Introduction:</em></strong><em> There is fluctuation of information with respect to seroprevalence and coinfection of hepatitis infections. Our goal was to decide the greatness, example and coinfection of hepatitis infections in clinically associated cases with intense irresistible hepatitis. <strong>Techniques:</strong> This illustrative examination was led in the Department of Pathology </em> <em>In Rawalpindi Medical College over a time of 1 year from January 2017 to December 2018. All the se-rum examples taken from subjects (n= 600 in study gathering and n=200 in control gather

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Riaz, Muhammad Nasir, Muhammad Faheem, Muhammad Ayaz Anwar, et al. "PCR-Based Molecular Diagnosis of Hepatitis Virus (HBV and HDV) in HCV Infected Patients and Their Biochemical Study." Journal of Pathogens 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/3219793.

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Seroprevalence of HCV indicates that HCV is found in more than 10% of HBV- or HDV-infected patients worldwide leading to liver disease. Here we show HBV and HDV coinfection association with HCV infected Pakistani patients, study of disease severity, and possible interpretation of associated risk factors in coinfected patients. A total of 730 liver diseased patients were included, out of which 501 were found positive for HCV infection via PCR. 5.1% of patients were coinfected with HBV while 1% were coinfected with HBV and HDV both. LFTs were significantly altered in dually and triply infected p

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Gheorghe, Liana, Speranta Iacob, Irma Eva Csiki, et al. "Unveiling Prevalence, Risk Factors, and Outcomes of Hepatitis D Among Vulnerable Communities in Romania." Viruses 17, no. 1 (2024): 52. https://doi.org/10.3390/v17010052.

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Background: Hepatitis B (HBV) and Delta (HDV) virus infections pose critical public health challenges, particularly in Romania, where HDV co-infection is underdiagnosed. Methods: This study investigates the epidemiology, risk factors, and clinical outcomes of HBV/HDV co-infection in vulnerable populations, leveraging data from the LIVE(RO2) program. Conducted between July 2021 and November 2023, the program screened 320,000 individuals across 24 counties, targeting socially disadvantaged groups such as rural residents, the Roma community, and those lacking health insurance. Results: Among 6813

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Lee, Grace Sanghee, Michael A. Purdy, and Youkyung Choi. "Cell Culture Systems for Studying Hepatitis B and Hepatitis D Virus Infections." Life 13, no. 7 (2023): 1527. http://dx.doi.org/10.3390/life13071527.

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The hepatitis B virus (HBV) and hepatitis D virus (HDV) infections cause liver disease, including hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). HBV infection remains a major global health problem. In 2019, 296 million people were living with chronic hepatitis B and about 5% of them were co-infected with HDV. In vitro cell culture systems are instrumental in the development of therapeutic targets. Cell culture systems contribute to identifying molecular mechanisms for HBV and HDV propagation, finding drug targets for antiviral therapies, and testing antiviral agents. Current HBV the

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Crobu, Maria Grazia, Paolo Ravanini, Clotilde Impaloni, et al. "Hepatitis C Virus as a Possible Helper Virus in Human Hepatitis Delta Virus Infection." Viruses 16, no. 6 (2024): 992. http://dx.doi.org/10.3390/v16060992.

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Previous studies reported that the hepatitis C virus (HCV) could help disseminate the hepatitis D virus (HDV) in vivo through the unrelated hepatitis B virus (HBV), but with essentially inconclusive results. To try to shed light on this still-debated topic, 146 anti-HCV-positive subjects (of whom 91 HCV/HIV co-infected, and 43 with prior HCV eradication) were screened for anti-HDV antibodies (anti-HD), after careful selection for negativity to any serologic or virologic marker of current or past HBV infection. One single HCV/HIV co-infected patient (0.7%) tested highly positive for anti-HD, bu

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Golkocheva-Markova, Elitsa, and Lilia Ganova-Raeva. "Editorial: Epidemiology and Control of Hepatitis Viruses." Life 14, no. 11 (2024): 1369. http://dx.doi.org/10.3390/life14111369.

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Five hepatitis viruses—hepatitis A (HAV), hepatitis B (HBV), hepatitis C (HCV), hepatitis D (HDV), and hepatitis E (HEV)—have a huge impact on human health with their ability to cause acute and often chronic infection [...]

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Groth, Christopher, Svea Wupper, Gnimah Eva Gnouamozi, Katrin Böttcher, and Adelheid Cerwenka. "Intrinsic Immune Response of HBV/HDV-Infected Cells and Corresponding Innate (Like) Immune Cell Activation." Livers 4, no. 4 (2024): 562–93. http://dx.doi.org/10.3390/livers4040040.

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Infection of hepatitis B (HBV) patients with hepatitis D (HDV) can cause the most severe form of viral hepatitis, leading to liver fibrosis, liver failure, and hepatocellular carcinoma. HDV relies on simultaneous infection with HBV for the generation of infectious viral particles. The innate immune response, which is weakly induced in HBV infection, becomes strongly activated upon HDV co-infection. In HBV/HDV co-infection, the immune system comprises a cell-intrinsic strong IFN response, which leads to the induction of interferon-stimulated genes (ISGs), the local activation of liver-resident

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Deng, Xuelian, Dan Liu, Maelenn Pailine Delcourt, Huihui Gao, Lu Zhou, and Daniel Candotti. "No Hepatitis Delta Virus Seropositivity among Blood Donors with Overt and Occult Hepatitis B Infection in Dalian, Liaoning Province, China." Viruses 15, no. 7 (2023): 1509. http://dx.doi.org/10.3390/v15071509.

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Hepatitis delta virus (HDV) is an obligate satellite of hepatitis B virus (HBV). Dual HDV/HBV infection is associated with down-regulated HBV replication and fast progression to severe liver disease. Although HDV is transmissible through exposure to infected blood, data about HDV infection in blood donors remain scarce. Between 2011 and 2021, 869,633 donations were collected from prequalified donors in Dalian, China. In total, 1060 (0.12%) were confirmed HBsAg and/or HBV DNA-reactive. Subsequently, anti-HDV IgG was tested in 2175 donations, including 65 that tested HBsAg+ pre donation, 1017 co

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Montoya-Guzman, Melissa, Jaime Martinez, Diana Castro-Arroyave, Carlos Rojas, and Maria-Cristina Navas. "Epidemiology and Genetic Diversity of Hepatitis B Virus and Hepatitis Delta Virus Infection in Indigenous Communities in Colombia." Microorganisms 11, no. 7 (2023): 1739. http://dx.doi.org/10.3390/microorganisms11071739.

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Despite the universal vaccination program, there are still regions and territories with a high prevalence of Hepatitis B Virus infection (HBV), such as the Amazon basin, where several indigenous communities live. Additionally, Hepatitis Delta Virus (HDV) is a defective that requires the hepatitis B surface antigen (HBsAg) for the assembly and release of de novo viral particles. Therefore, hepatitis D could be the result of HBV/HDV coinfection or HDV superinfection in individuals with chronic hepatitis B. Among the high prevalence HDV populations are indigenous communities of America. This stud

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Taylor, John M. "Infection by Hepatitis Delta Virus." Viruses 12, no. 6 (2020): 648. http://dx.doi.org/10.3390/v12060648.

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Hepatitis delta virus (HDV) and hepatitis B virus (HBV) are blood-borne viruses that infect human hepatocytes and cause significant liver disease. Infections with HBV are more damaging when there is a coinfection with HDV. The genomes and modes of replication of these two viruses are fundamentally different, except for the fact that, in nature, HDV replication is dependent upon the envelope proteins of HBV to achieve assembly and release of infectious virus particles, ones that use the same host cell receptor. This review focuses on what has been found of the various ways, natural and experime

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Tseligka, Eirini D., Sophie Clément, and Francesco Negro. "HDV Pathogenesis: Unravelling Ariadne’s Thread." Viruses 13, no. 5 (2021): 778. http://dx.doi.org/10.3390/v13050778.

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Hepatitis Delta virus (HDV) lies in between satellite viruses and viroids, as its unique molecular characteristics and life cycle cannot categorize it according to the standard taxonomy norms for viruses. Being a satellite virus of hepatitis B virus (HBV), HDV requires HBV envelope glycoproteins for its infection cycle and its transmission. HDV pathogenesis varies and depends on the mode of HDV and HBV infection; a simultaneous HDV and HBV infection will lead to an acute hepatitis that will resolve spontaneously in the majority of patients, whereas an HDV super-infection of a chronic HBV carri

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Basimane-Bisimwa, Parvine, Giscard Wilfried Koyaweda, Edgarthe Ngaïganam, et al. "Seroprevalence and molecular characterization of viral hepatitis and HIV co-infection in the Central African Republic." PLOS ONE 19, no. 5 (2024): e0291155. http://dx.doi.org/10.1371/journal.pone.0291155.

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Background The Central African Republic (CAR) is one of the countries with the highest prevalence of viral hepatitis infection in the world. Coinfection with HIV increases the morbidity and mortality beyond that of mono-infection with either hepatitis or HIV. The present study describes the geographic distribution of viral hepatitis infections and molecular characterization of these viruses in the CAR. Methodology Out of 12,599 persons enrolled during the fourth Multiple Indicator Cluster Survey of 2010 in the CAR, 10,621 Dried Blood Spot (DBS) samples were obtained and stored at -20°C. Of the

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Tsuge, Masataka, Takuro Uchida, Kevin Walsh, et al. "Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection." Viruses 11, no. 3 (2019): 263. http://dx.doi.org/10.3390/v11030263.

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Backgrounds and Aims: We previously demonstrated that serum hepatitis B virus (HBV) DNA in HBV infected humanized mice exhibited a highly dynamic multiphasic kinetic pattern from infection initiation to steady-state. Here, we investigated whether this pattern is consistent across different HBV clones or in the presence of hepatitis D virus (HDV) co-infection. Methods: We analyzed early serum viral kinetics using 26 HBV genotype C (GtC) mono-infected mice [clones: PXB, Hiroshima GtC CL4 (CL4) and Hiroshima GtC CL5 (CL5)] and four HBV CL4/HDV genotype one co-infected mice. Results: The HBV kinet

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Botelho-Souza, Luan Felipo, Deusilene Souza Vieira, Alcione de Oliveira dos Santos, André Vinycius Cunha Pereira, and Juan Miguel Villalobos-Salcedo. "Characterization of the Genotypic Profile of Hepatitis Delta Virus: Isolation of HDV Genotype-1 in the Western Amazon Region of Brazil." Intervirology 58, no. 3 (2015): 166–71. http://dx.doi.org/10.1159/000431040.

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The hepatitis delta virus (HDV) is a hepatotropic subvirus that is dependent on the hepatitis B virus (HBV) and supplies the viral envelope containing the surface antigen of hepatitis B. Viral genetic diversity is related to the geographical origin of the isolates, and there are at least eight genotypes that are referred to as HDV-1 through HDV-8. HDV-3 is responsible for epidemics of severe and fulminant hepatitis, which are common in northeastern South America. HDV-3 is prevalent in the Brazilian Amazon and is associated with the increased aggressiveness of HDV infections. Although isolated,

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Prasetyo, Afiono Agung, Paramasari Dirgahayu, Yulia Sari, Hudiyono Hudiyono, and Seiji Kageyama. "Molecular epidemiology of HIV, HBV, HCV, and HTLV-1/2 in drug abuser inmates in central Javan prisons, Indonesia." Journal of Infection in Developing Countries 7, no. 06 (2013): 453–67. http://dx.doi.org/10.3855/jidc.2965.

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Introduction: This study was conducted to determine the current molecular prevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and human T lymphotropic virus-1/2 (HTLV-1/2) circulating among drug abuser inmates incarcerated in prisons located in Central Java, Indonesia. Methodology: Socio-epidemiological data and blood specimens were collected from 375 drug abuser inmates in four prisons. The blood samples were analyzed with serological and molecular testing for HIV, HBV, HCV, HDV, and HTLV-1/2. Results: The seroprevalence

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Elbahrawy, Ashraf, Hassan Atalla, Mohamed Alboraie, et al. "Recent Advances in Protective Vaccines against Hepatitis Viruses: A Narrative Review." Viruses 15, no. 1 (2023): 214. http://dx.doi.org/10.3390/v15010214.

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Vaccination has been confirmed to be the safest and, sometimes, the only tool of defense against threats from infectious diseases. The successful history of vaccination is evident in the control of serious viral infections, such as smallpox and polio. Viruses that infect human livers are known as hepatitis viruses and are classified into five major types from A to E, alphabetically. Although infection with hepatitis A virus (HAV) is known to be self-resolving after rest and symptomatic treatment, there were 7134 deaths from HAV worldwide in 2016. In 2019, hepatitis B virus (HBV) and hepatitis

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Mohajan, Haradhan Kumar. "Clinical Practice, and Diagnosis and Treatment Strategies of Chronic Hepatitis D Virus (HDV)." Innovation in Science and Technology 4, no. 4 (2025): 26–32. https://doi.org/10.63593/ist.2788-7030.2025.05.003.

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Hepatitis is the liver inflammatory disease that gradually damages the liver. Hepatitis D/delta hepatitis is a liver infection caused by the hepatitis D virus (HDV). The HDV is a blood-borne pathogen and only occurs as either a co-infection with hepatitis B virus (HBV) or as a super-infection of persons with chronic HBV. It can be an acute for short-term infection or become a long-term chronic infection. In chronic infection HDV can cause serious liver damage (cirrhosis) and death at the end stage. The HDV infection is more common in Eastern Europe, South America, Africa, Central Asia, and the

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Miao, Zhijiang, Shaoshi Zhang, Xumin Ou, et al. "Estimating the Global Prevalence, Disease Progression, and Clinical Outcome of Hepatitis Delta Virus Infection." Journal of Infectious Diseases 221, no. 10 (2019): 1677–87. http://dx.doi.org/10.1093/infdis/jiz633.

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Abstract Background Hepatitis delta virus (HDV) coinfects with hepatitis B virus (HBV) causing the most severe form of viral hepatitis. However, its exact global disease burden remains largely obscure. We aim to establish the global epidemiology, infection mode-stratified disease progression, and clinical outcome of HDV infection. Methods We conducted a meta-analysis with a random-effects model and performed data synthesis. Results The pooled prevalence of HDV is 0.80% (95% confidence interval [CI], 0.63–1.00) among the general population and 13.02% (95% CI, 11.96–14.11) among HBV carriers, co

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Pérez-Vargas, Jimena, Rémi Pereira de Oliveira, Stéphanie Jacquet, Dominique Pontier, François-Loïc Cosset, and Natalia Freitas. "HDV-Like Viruses." Viruses 13, no. 7 (2021): 1207. http://dx.doi.org/10.3390/v13071207.

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Hepatitis delta virus (HDV) is a defective human virus that lacks the ability to produce its own envelope proteins and is thus dependent on the presence of a helper virus, which provides its surface proteins to produce infectious particles. Hepatitis B virus (HBV) was so far thought to be the only helper virus described to be associated with HDV. However, recent studies showed that divergent HDV-like viruses could be detected in fishes, birds, amphibians, and invertebrates, without evidence of any HBV-like agent supporting infection. Another recent study demonstrated that HDV can be transmitte

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Ndzie Ondigui, Juliette-Laure, Nadège Mafopa Goumkwa, Cindy Lobe, et al. "Prevalence and risk factors of transmission of hepatitis delta virus in pregnant women in the Center Region of Cameroon." PLOS ONE 19, no. 6 (2024): e0287491. http://dx.doi.org/10.1371/journal.pone.0287491.

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Background Hepatitis B virus (HBV) and hepatitis delta virus (HDV) co-infection has been described as the most severe form of viral hepatitis, and can be co-transmitted from mother-to-child. A seroprevalence of 4.0% of HDV infection was reported in pregnant women in Yaoundé, and 11.9% in the general population in Cameroon. Our objective was to describe the rate of HDV infection in HBsAg-positive pregnant women and to determine risk factors associated with mother-to-child transmission of HDV. Materials and methods A cross-sectional, descriptive study was conducted from January 2019 to July 2022

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Yan, Huan, and Wenhui Li. "Sodium Taurocholate Cotransporting Polypeptide Acts as a Receptor for Hepatitis B and D Virus." Digestive Diseases 33, no. 3 (2015): 388–96. http://dx.doi.org/10.1159/000371692.

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Infection of hepatitis B virus (HBV) remains a major public health problem worldwide. Understanding the viral infection and developing antivirals against HBV have been hampered by the lack of convenient culture systems and animal models for the infection. Sodium taurocholate cotransporting polypeptide (NTCP), a key bile acid transporter expressed in liver, was recently identified as a critical receptor for viral entry of HBV and its satellite virus hepatitis D virus (HDV). This finding enabled a reliable cell culture system for the viruses. Detailed studies have shown that NTCP is the major de

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SHABIR SHAIKH, GHULAM, AKBAR ALI SOOMRO, NISAR AHMED SHAIKH, Ghulam Murtaza Pathan, Abdul Majeed Chhutto, and Zameer Ahmed Shaikh. "HDV INFECTION IN HBV INFECTED INDIVIDUALS." Professional Medical Journal 19, no. 04 (2012): 549–52. http://dx.doi.org/10.29309/tpmj/2012.19.04.2281.

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Objective: To determine the status of HDV infection in HBV infected individuals at Larkana. Duration & place of study: This is alaboratory based retrospective study conducted at Molecular Laboratory HPCP-CMI Central laboratory CMC Hospital City block Larkana fromOctober 2010 to September 2011. Material & methods: During the study period all the serum samples in which the HBV DNA was qualitativelydetected werefurther processed for HDV RNA detection by the method of Real time PCR. Result: During the study period a total of 1564 HBVDNA detected serum samples were processed for HDV RNA det

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Liou, Je-Wen, Hemalatha Mani, and Jui-Hung Yen. "Viral Hepatitis, Cholesterol Metabolism, and Cholesterol-Lowering Natural Compounds." International Journal of Molecular Sciences 23, no. 7 (2022): 3897. http://dx.doi.org/10.3390/ijms23073897.

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Hepatitis is defined as inflammation of the liver; it can be acute or chronic. In chronic cases, the prolonged inflammation gradually damages the liver, resulting in liver fibrosis, cirrhosis, and sometimes liver failure or cancer. Hepatitis is often caused by viral infections. The most common causes of viral hepatitis are the five hepatitis viruses—hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). While HAV and HEV rarely (or do not) cause chronic hepatitis, a considerable proportion of acute hepatitis cases caused

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Cardoso, Mariana Ferreira, and Mariana Verdelho Machado. "The Changing Face of Hepatitis Delta Virus Associated Hepatocellular Carcinoma." Cancers 16, no. 22 (2024): 3723. http://dx.doi.org/10.3390/cancers16223723.

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Hepatitis delta virus (HDV) infection requires the presence of hepatitis B virus (HBV), and chronic HBV–HDV coinfection is considered the most severe form of viral hepatitis. When compared with HBV mono-infection, HBV–HDV coinfection is associated with higher rates of liver cirrhosis and hepatocellular carcinoma (HCC). In this review, we aim to elucidate the complex relationship between HDV infection and the development of HCC. The exact mechanisms underlying the carcinogenic potential of HDV remain to be fully elucidated. Evidence suggests that HDV has both indirect and direct oncogenic effec

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Colagrossi, Luna, Romina Salpini, Rossana Scutari, et al. "HDV Can Constrain HBV Genetic Evolution in HBsAg: Implications for the Identification of Innovative Pharmacological Targets." Viruses 10, no. 7 (2018): 363. http://dx.doi.org/10.3390/v10070363.

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Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection. However, to-date no direct anti-HDV drugs are available in clinical practice. Here, we identified conserved and variable regions in HBsAg and HDAg domains in HBV + HDV infection, a critical finding for the design of innovative therapeutic agents. The extent of amino-acid variability was measured by Shannon-Entropy (Sn) in HBsAg genotype-d sequences from 31 HBV + HDV infected and 62 HBV mono-infected patients

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Abdul Rabb Bhutto, Amanullah Abbasi, Shumaila Rafi, Khalil ur Rehman, Syed Tehseen Akhtar, and Muhammad Hussain Haroon. "Hepatitis D seroprevalence: An alarming situation and war without weapon." Professional Medical Journal 31, no. 02 (2024): 176–82. http://dx.doi.org/10.29309/tpmj/2024.31.02.7870.

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Objective: To determine the seroprevalence of HDV in HBs Ag positive patients and the burden of true viral hepatitis infection (viremia) as evidenced by detectable either HBV DNA and/or HDV RNA (single or dual infection). Study Design: Cross-sectional Observational Study. Setting: Al-Tibri Medical College Hospital, Karachi, and OPD Saylani Welfare Trust, Karachi. Period: August 2021 to July 2022. Material & Methods: All patients of both genders with HBsAg positivity were included in the study. All included subjects underwent a process of evaluation through history, physical examination, ba

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Ifeorah, Ijeoma M., Athenais Gerber, Samira Dziri, et al. "The Prevalence and Molecular Epidemiology of Hepatitis Delta Virus in Nigeria: The Results of a Nationwide Study." Viruses 16, no. 8 (2024): 1236. http://dx.doi.org/10.3390/v16081236.

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Hepatitis delta virus (HDV) is a satellite of hepatitis B virus (HBV), which requires the HBV surface antigen (HBsAg) for its assembly and propagation. Although countries affected by HBV infection in Africa are well identified, data on HDV infection are still scarce, like in Nigeria, where HBV infection is endemic. In this study, we aimed to determine the prevalence of HDV infection and identify the circulating genotypes/strains in the country. A nationwide study was performed on 1281 HBsAg-positive samples collected from patients across eleven sites drawn from the six geopolitical zones in Ni

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Park, Heiyoung, Theo Heller, and Barbara Rehermann. "Transcriptome analysis reveals distinct immune response profiles in HBeAg+ and HBeAg− HBV infection and in HBV/HDV co-infection." Journal of Immunology 198, no. 1_Supplement (2017): 158.18. http://dx.doi.org/10.4049/jimmunol.198.supp.158.18.

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Abstract In chronic hepatitis B virus (HBV) infection, HBeAg positivity is associated with an increase in liver inflammation and progression to liver cirrhosis and cancer. Super-infection with hepatitis D virus (HDV) results in more severe liver disease. The causative factors are unknown. To understand the unique immunopathogenesis of HBeAg+ chronic HBV infection and chronic HBV/HDV co-infection, we performed a comparative transcriptome analysis using peripheral blood mononuclear cells of 12 HBV infected patients (6 HBeAg+ vs. 6 HBeAg−), 10 HBV/HDV co-infected patients, and 12 uninfected contr

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Carpentier, Arnaud. "Cell Culture Models for Hepatitis B and D Viruses Infection: Old Challenges, New Developments and Future Strategies." Viruses 16, no. 5 (2024): 716. http://dx.doi.org/10.3390/v16050716.

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Chronic Hepatitis B and D Virus (HBV and HDV) co-infection is responsible for the most severe form of viral Hepatitis, the Hepatitis Delta. Despite an efficient vaccine against HBV, the HBV/HDV infection remains a global health burden. Notably, no efficient curative treatment exists against any of these viruses. While physiologically distinct, HBV and HDV life cycles are closely linked. HDV is a deficient virus that relies on HBV to fulfil is viral cycle. As a result, the cellular response to HDV also influences HBV replication. In vitro studying of HBV and HDV infection and co-infection rely

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Zovich, Beatrice, Catherine Freeland, Holly Moore, et al. "Dismantling Barriers to Hepatitis B and Delta Screening, Prevention, and Linkage to Care among the PWUD Community in Philadelphia." Viruses 16, no. 4 (2024): 628. http://dx.doi.org/10.3390/v16040628.

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The prevalence of hepatitis B and delta viruses (HBV/HDV) among people who use drugs (PWUD) remains largely unknown. In the context of one Philadelphia-based harm reduction organization (HRO), this study aimed to assess HBV/HDV prevalence and facilitate linkage to care. Participants completed a demographic HBV/HDV risk factor survey and were screened for HBV and reflexively for HDV if positive for HBV surface antigen or isolated core antibody. Fisher’s exact tests and regression were used to understand relationships between risks and HBV blood markers. Of the 498 participants, 126 (25.3%) did

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Morakinyo, Julianah D., Oladele O. Opaleye, Olusola Ojurongbe, et al. "Prevalence of Hepatitis D Virus (HDV) in HBV/HIV Co-Infected Patients in Ogbomoso, Nigeria." International Journal of Research and Scientific Innovation XII, no. XV (2025): 145–54. https://doi.org/10.51244/ijrsi.2025.121500013p.

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Hepatitis D virus (HDV) requires co-infection with hepatitis B virus (HBV). Human immunodeficiency virus (HIV) shares transmission routes with these viruses. HDV infection increases liver complications compared to HBV alone, especially in HIV-positive people. Although vaccinations and antiviral medications are available, over 1 million individuals worldwide die from HBV-related illnesses each year, which may also co-infect with HDV. Examining HDV infection in HBV/HIV co-infected individuals would provide important epidemiological information for improving healthcare delivery in Nigeria. Using

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Chu, Chia-Ming, Chau-Ting Yeh, and Yun-Fan Liaw. "Viral Superinfection in Previously Unrecognized Chronic Carriers of Hepatitis B Virus with Superimposed Acute Fulminant versus Nonfulminant Hepatitis." Journal of Clinical Microbiology 37, no. 1 (1999): 235–37. http://dx.doi.org/10.1128/jcm.37.1.235-237.1999.

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The role of viral superinfection in hepatitis B surface antigen carriers with superimposed fulminant (n = 60) versus nonfulminant (n = 90) acute hepatitis was studied. The frequency of hepatitis A virus (HAV) (0 versus 2.2%), HCV (18.3 versus 21.1%), HDV (15.0 versus 7.8%), and HEV (1.7 versus 4.4%) infection showed no significant difference, while simultaneous HCV and HDV infection was significantly more prevalent in the former (8.3 versus 0%). Only 3.6% of fulminant cases and 3.3% of nonfulminant controls were HGV RNA positive.

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Tserashkou, D. V., V. M. Mitsura, E. V. Voropaev, and O. V. Osipkina. "VIRAL COINFECTIONS IN PATIENTS WITH CHRONIC HEPATITIS B: THEIR PREVALENCE AND CLINICAL SIGNIFICANCE." Hepatology and Gastroenterology 4, no. 2 (2020): 171–76. http://dx.doi.org/10.25298/2616-5546-2020-4-2-171-176.

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Background. Hepatitis B virus (HBV) infection remains a global public health problem. Objective – to analyze the prevalence of viral coinfections with human immunodefciency virus (HIV), hepatitis C virus (HCV), hepatitis delta virus (HDV), TT-viruses and SENV in patients with chronic hepatitis B (CHB) and to assess their inﬂuence on liver disease severity. Material and methods. The observational cross-sectional study included 287 patients with chronic hepatitis B virus (HBV) – those with monoinfection and coinfected with HIV, HCV, HDV. Routine hematological and biochemical tests were performed

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Barrera, Azeneth, Bernadette Guerra, Lena Notvall, and Robert E. Lanford. "Mapping of the Hepatitis B Virus Pre-S1 Domain Involved in Receptor Recognition." Journal of Virology 79, no. 15 (2005): 9786–98. http://dx.doi.org/10.1128/jvi.79.15.9786-9798.2005.

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ABSTRACT Hepatitis B virus (HBV) and woolly monkey hepatitis B virus (WMHBV) are primate hepadnaviruses that display restricted tissue and host tropisms. Hepatitis D virus (HDV) particles pseudotyped with HBV and WMHBV envelopes (HBV-HDV and WM-HDV) preferentially infect human and spider monkey hepatocytes, respectively, thereby confirming host range bias in vitro. The analysis of chimeric HBV and WMHBV large (L) envelope proteins suggests that the pre-S1 domain may comprise two regions that affect infectivity: one within the amino-terminal 40 amino acids of pre-S1 and one downstream of this r

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Schlaak, Jörg F. "Current Therapy of Chronic Viral Hepatitis B, C and D." Journal of Personalized Medicine 13, no. 6 (2023): 964. http://dx.doi.org/10.3390/jpm13060964.

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The majority of chronic viral hepatitis cases are induced via infection with the hepatitis B virus (HBV), hepatitis C virus (HCV), or hepatitis D virus (HDV). These patients are at increased risk for progressive liver disease leading to cirrhosis as well as hepatocellular carcinoma (HCC). HBV infection is well controlled by the currently available nucleosides as well as nucleotides, and the development of cirrhosis can be prevented. Additionally, it has been shown that HBV-induced liver fibrosis can regress during successful antiviral treatment; however, a “functional cure”, i.e., loss of HBsA

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He, Wenhui, Zhiliang Cao, Fengfeng Mao, et al. "Modification of Three Amino Acids in Sodium Taurocholate Cotransporting Polypeptide Renders Mice Susceptible to Infection with Hepatitis D VirusIn Vivo." Journal of Virology 90, no. 19 (2016): 8866–74. http://dx.doi.org/10.1128/jvi.00901-16.

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ABSTRACTSodium taurocholate cotransporting polypeptide (NTCP) was identified as a functional receptor for hepatitis D virus (HDV) and its helper hepatitis B virus (HBV). In cultured cell lines, HDV infection through mouse NTCP is restricted by residues 84 to 87 of the receptor. This study shows that mice with these three amino acids altered their corresponding human residues (H84R, T86K, and S87N) in endogenous mouse NTCP supportde novoHDV infectionin vivo. HDV infection was documented by the presence of replicative forms of HDV RNA and HDV proteins in liver cells at day 6 after viral inoculat

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Kartashov, Mikhail Yu, Kirill A. Svirin, Ekaterina I. Krivosheina, Elena V. Chub, Vladimir A. Ternovoi, and Galina V. Kochneva. "Prevalence and molecular genetic characteristics of parenteral hepatitis B, C and D viruses in HIV positive persons in the Novosibirsk region." Problems of Virology 67, no. 5 (2022): 423–38. http://dx.doi.org/10.36233/0507-4088-133.

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Introduction. Parenteral viral hepatitis (B, C, D) and HIV share modes of transmission and risk groups, in which the probability of infection with two or more of these viruses simultaneously is increased. Mutual worsening of the course of viral infections is important issue that occurs when HIV positive patients are coinfected with parenteral viral hepatitis. The aim of the study was to determine the prevalence of HCV, HBV and HDV in HIV positive patients in the Novosibirsk region and to give molecular genetic characteristics of their isolates. Materials and methods. Total 185 bloo

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Braga, Wornei Silva Miranda, Márcia da Costa Castilho, Fabiane Giovanella Borges, et al. "Hepatitis D virus infection in the Western Brazilian Amazon - far from a vanishing disease." Revista da Sociedade Brasileira de Medicina Tropical 45, no. 6 (2012): 691–95. http://dx.doi.org/10.1590/s0037-86822012000600007.

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INTRODUCTION: A decline in hepatitis D virus (HDV) occurrence was described in Europe and Asia. We estimated HDV prevalence in the Brazilian Amazon following hepatitis B vaccination. METHODS: This is a cross-sectional survey of HDV measured by total antibodies to HDV (anti-HD T). RESULTS: HDV prevalence was 41.9% whiting HBsAg carries and was associated with age (PR = 1.96; 95% CI 1.12-3.42; p = 0.01), hepatitis B virus (HBV) infection (PR = 4.38; 95% CI 3.12-6.13; p < 0.001), and clinical hepatitis (PR =1.44; 95% CI 1.03-2.00; p = 0.03). Risk factors were related to HDV biology, clinical o

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