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Relevant bibliographies by topics / Human insulin

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Academic literature on the topic 'Human insulin'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Human insulin"

1

Ray, Sumit. "Insulin infusion protocol (Human insulin®/Insugen®)." Current Medicine Research and Practice 4, no. 4 (2014): 186–87. http://dx.doi.org/10.1016/j.cmrp.2014.08.007.

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Mbanya, Jean Claude, Juergen Sandow, Wolfgang Landgraf, and David R. Owens. "Recombinant Human Insulin in Global Diabetes Management – Focus on Clinical Efficacy." European Endocrinology 13, no. 01 (2017): 21. http://dx.doi.org/10.17925/ee.2017.13.01.21.

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Biosynthetic human insulin and insulin analogues are the mainstay of insulin therapy for both type 1 and type 2 diabetes although access to human insulin at affordable prices remains a global issue. The world is experiencing an exponential rise in the prevalence of diabetes presenting an urgent need to establish effective diabetes therapy in countries burdened by inadequate health care budgets, malnutrition and infectious diseases. Recombinant human insulin has replaced animal insulins and animal-based semisynthetic human insulin thereby available in sufficient quantities and at affordable pri

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Sandow, Juergen, Wolfgang Landgraf, Reinhard Becker, and Gerhard Seipke. "Equivalent Recombinant Human Insulin Preparations and their Place in Therapy." European Endocrinology 11, no. 1 (2015): 10. http://dx.doi.org/10.17925/ee.2015.11.01.10.

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Recombinant human insulin was one of the first products of biotechnology. It was developed in response to the need for a consistent and sufficient worldwide supply. Recombinant human insulin replaced the animal insulins and semisynthetic insulins obtained by modification of animal insulins. Bioequivalence studies were required for regulatory approval. Three reference products were independently established during these procedures: Humulin® (Eli Lilly and Co), Novolin® (NovoNordisk) and Insuman® (Sanofi). Numerous brand names have been used during the commercial development of recombinant human

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Hale, Genevieve, Valerie Marcellus, Tina Benny, Cynthia Moreau, Elaina Rosario, and Alexandra Perez. "Real-World Analysis of Long-Acting and NPH-Containing Insulins on Glycemic Control." Senior Care Pharmacist 39, no. 1 (2024): 42–49. http://dx.doi.org/10.4140/tcp.n.2024.42.

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Introduction Affordability of insulin products has become a concern in the past several years as the average price of various insulin products has increased. While awaiting legislation at the federal level that would address issues leading to high insulin costs, providers may have shifted prescribing practices to prescribe the lowest-priced insulin products to achieve patients’ treatment goals. Objective To compare the prevalence of hypoglycemic events between patients receiving lower-cost neutral protamine Hagedorn (NPH)-containing human insulins and higher-cost long-acting insulin analogs in

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Ahmed Aziz, Kamran Mahmood. "Role of New Insulin Analogs in the Management of Diabetes. A Clinical Review." Diabetes & Obesity International Journal 8, no. 1 (2023): 1–8. http://dx.doi.org/10.23880/doij-16000269.

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This paper has reviewed different insulin analogs currently available in the market and pharma industry, their safety, efficacy and their roles in the diabetes management, comparing with human regular and NPH insulin. Traditional insulins (human regular and NPH insulins) do not have constant or smoother pharmacokinetic and pharmacodynamic profiles and are usually associated with erratic blood glucose profiles with hypoglycemia or hyperglycemia when compared with analog insulins. Similarly they do not match physiologic insulin profiles with basal bolus format. According to the medical literatur

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Dzhavakhishvili, T. S., T. I. Romantsova, and O. V. Roik. "Influence of the dynamics of body weight on the risk factors of cardiovascular disease in patients with type 2 diabetes during the first year of insulin treatment." Obesity and metabolism 10, no. 1 (2013): 22–25. http://dx.doi.org/10.14341/2071-8713-5067.

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The aim of the present study was to investigate whether insulin treatment-induced weight gain had an adverse impact on cardiovascular risk factors in insulin-treated type 2 diabetic patients during the first year after initiating insulin therapy when insulin analogues or human insulins are used. A total of 157 patients with newly insulinized type 2 diabetes were included in the study. The patients were divided in two groups. First group consisted of subjects (mean age 57 [45; 73], duration of diabetes of 10 years [4; 16]) who had received long-acting basal (glargine, detemir), premixed (biphas

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Broussard, John D., and Mark E. Peterson. "Comparison of two ultralente insulin preparations with protamine zinc insulin in clinically normal cats." American Journal of Veterinary Research 55, no. 1 (1994): 127–31. http://dx.doi.org/10.2460/ajvr.1994.55.01.127.

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Summary The absorption kinetics and glycemic effects of 3 long-acting insulin preparations (protamine zinc beefpork insulin, ultralente beef-pork insulin, and ultralente human insulin) were evaluated in 9 healthy, adult, domestic shorthair cats (6 males, 3 females). A triple crossover study was performed, in which the serial serum concentrations of insulin and glucose were determined over a 24-hour period after SC administration of the 3 insulin preparations (dosage, 1.0 U/kg of body weight) at 3-week intervals. A control study was also performed in 4 of the cats by serially collecting samples

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Ndayishimye, Samuel *. Prudence A. Rodrigues. "HUMAN INSULIN AND INSULIN ANALOGUES IN MANAGEMENT OF DIABETES MELLITUS." Journal of Pharma Research 7, no. 10 (2018): 224–26. https://doi.org/10.5281/zenodo.1468476.

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<em>ABSTRACT</em> <strong><em>T</em></strong><em>he aim of the study was to determine the outcomes of human insulin and insulin analogues in the management of diabetes mellitus. Since good glycemic control is needed for diabetic insulin analogues are having faster onset and shorter duration of action when compared to human insulin. Insulin analogues show improvements in clinical outcomes, medication adherence and patient satisfaction. When compared with human insulin, insulin analogues are having lesser episodes of hypoglycemia. Premixed insulin analogues show little benefits than Rapid and lo

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&NA;. "Insulin human." Reactions Weekly &NA;, no. 587 (1996): 5. http://dx.doi.org/10.2165/00128415-199605870-00017.

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&NA;. "Insulin human." Reactions Weekly &NA;, no. 588 (1996): 8. http://dx.doi.org/10.2165/00128415-199605880-00025.

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Dissertations / Theses on the topic "Human insulin"

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Karlsson, Håkan K. R. "Insulin signaling and glucose transport in insulin resistant human skeletal muscle /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-469-4/.

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Krook, Anna Christina. "Insulin receptor mutations in human disease." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266558.

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Argyraki, M. "Studies of insulin action in human muscle." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234398.

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Hurel, Steven J. "Insulin action in cultured human skeletal muscle." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363891.

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Danielsson, Anna. "Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes." Doctoral thesis, Linköping : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-10327.

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El, Bilali Jason. "Effects of Chronic Insulin and High Glucose on Insulin-Stimulated Responses in Human Preadipocytes." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34109.

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The preadipocyte is crucial for healthy adipose tissue (AT) remodeling, and insulin resistance in these cells may contribute to AT dysfunction. Chronic exposure to insulin and high glucose induces insulin resistance in the 3T3-L1 mouse adipocyte cell line in vitro, however, whether this occurs in human preadipocytes is not known. To investigate this, human preadipocytes were isolated from subcutaneous AT obtained from 6 female patients undergoing elective surgery (Research Ethics Board-approved). Human preadipocytes were incubated in 5 mM glucose or 25 mM glucose in the presence or absence of

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Humphreys, P. "Biochemical and genetic studies of human insulin resistance." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604777.

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Biochemical characterisation of fibroblasts from patients with one sub-type of severe insulin resistance, pseudo-acromegalic insulin resistance, was undertaken in order to localise the site of defective insulin signalling. The studies which were carried out can be divided into 1) verification of normal insulin receptor function 2) measurement of metabolic and mitogenic end-point actions of insulin and 3) analysis of components of the signalling cascade. In brief, in most studies the response in patient cells was indistinguishable from normal controls. However, in patient cells there was reduce

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Pickersgill, Laura. "Lipid-induced insulin resistance in human skeletal muscle." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413955.

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Boyd, Alison Catherine. "Clinical and experimental studies on glycated human insulin." Thesis, University of Ulster, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390153.

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Humphreys, Phillippa. "Genetic and biochemical studies of human insulin resistance." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264507.

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Books on the topic "Human insulin"

1

Owens, D. R. Human Insulin. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4161-8.

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International, Symposium on "Hypoglycaemia and Human Insulin" (1990 Munich Germany). Hypoglycaemia and human insulin. G. Thieme, 1991.

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Markussen, Jan. Human Insulin by Tryptic Transpeptidations of Porcine Insulin and Biosynthetic Precursors. Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3187-9.

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Markussen, Jan. Human insulin by tryptic transpeptidations of porcine insulin and biosynthetic procursors. MTP Press, 1987.

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5

Clark, Andrew Richard. Transcriptional regulation of the human insulin gene. University ofBirmingham, 1992.

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Boehm, T. L. J., U. Deuschle, W. J. Kuhns, et al. Oncogenes and Human Cancer Blood Groups in Cancer Copper and Inflammation Human Insulin. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70570-0.

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Boehm, T. L. J. 1956-, ed. Oncogenes and human cancer, blood groups in cancer, copper and inflammation, human insulin. Springer-Verlag, 1985.

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8

Marttinen, Aulis. The insulin receptor on human erythrocyte: Short-term changes in binding activity and association with insulin degradation. University of Tampere, 1990.

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9

Teuscher, Arthur. Insulin: A voice for choice. Karger, 2007.

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Hammond-Kosack, Michael Christian Ulrich. An investigation of DNA structure in the human insulin gene. University of Birmingham, 1990.

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Book chapters on the topic "Human insulin"

1

Owens, D. R. "Introduction." In Human Insulin. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4161-8_1.

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Owens, D. R. "Objectives of Investigations." In Human Insulin. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4161-8_2.

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Owens, D. R. "Investigational Procedures." In Human Insulin. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4161-8_3.

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Owens, D. R. "Clinical-Pharmacological Studies." In Human Insulin. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4161-8_4.

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Owens, D. R. "Summary." In Human Insulin. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4161-8_5.

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Brange, Jens. "Human Insulin." In Galenics of Insulin. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-02526-0_4.

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Tager, H. S. "Mutant Human Insulins and Insulin Structure-Function Relationships." In Insulin. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-74098-5_3.

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Markussen, Jan. "Transpeptidation of porcine insulin to human insulin esters." In Human Insulin by Tryptic Transpeptidations of Porcine Insulin and Biosynthetic Precursors. Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3187-9_4.

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Whillier, Stephney. "Exercise and Insulin Resistance." In Physical Exercise for Human Health. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-1792-1_9.

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Wada, Jun, and Yashpal S. Kanwar. "Prominent Insulin Resistance in Congenital Generalized Lipoatrophy." In Human Pathobiochemistry. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-2977-7_3.

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Conference papers on the topic "Human insulin"

1

Nowak-Göttl, U., W. D. Kreuz, M. John, et al. "HAEMOSTASEOLOGICAL CHANGES IN DIABETIC CHILDREN (HUMAN INSULIN VERSUS PORCINE INSULIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643099.

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Changes of haemostaseological parameters are involved in pathogenesis of diabetic angiopathy. However it is not yet clear whether they are cause or consequence of the endothelial damage. We investigated coagulation parameters in 84 children with type I diabetes mellitus without clinical signs of vascular disease.Compared to the control group no significant changes could be seen in fibrinogen, plasminogen, protein C, α 1 antichymotrypsin, β-thrombo-globulin and ristocetin - induced aggregation.Additionally we could observe significant differences in patients treated with human insulin to those

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Pfliegler, G., J. Arnout, J. Kienast, K. Wittevrongel, and J. Vermylen. "INSULIN RECEPTORS ARE NOT COUPLED TO THE PHOSPHOINOSITIDE OR ADENYLCYCLASE MESSENGER SYSTEMS IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644523.

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Insulin receptors have been found not only on its “target Cells” but also on several other cell-types, including human platelets. From studies on adipocytes and liver cells it seems that they are coupled both to the adenylate cyclase-cyclic AMP and the polyphosphoinositide messenger systems. Circulating blood cells might faithfully reflect the insulin receptor state of target organ tissues. Impaired platelet function has an important role in the pathogenesis of vascular and thrombotic complications in diabetes mellitus, and insulin seems to act directly on platelets. A reduction in the number

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Smith, Nadine Barrie, Seungjun Lee, and K. Kirk Shung. "Noninvasive Ultrasound Mediated Transdermal Transport of Insulin Across Ex Vivo Human Skin." In ASME 2002 Pressure Vessels and Piping Conference. ASMEDC, 2002. http://dx.doi.org/10.1115/pvp2002-1633.

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The purpose of this research was to improve low frequency (20 kHz) ultrasound methods for enhancing the transport of insulin across ex vivo human skin. The feasibility of using ultrasound produced by small, lightweight novel transducers was explored for enhancing the transport of insulin across skin. Previous investigators have used ultrasound devices such as large, heavy sonicators or commercially obtained transducers for this type of research. These experiments used two low-profile novel ultrasound transducer arrays, the stack and standard array, for improved transport of insulin. The stack

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Nowacka, Olga, Katarzyna Miłowska, Maksim Ionov, and Maria Bryszewska. "Influence of PAMAM dendrimers on the human insulin." In THE SECOND ICRANET CÉSAR LATTES MEETING: Supernovae, Neutron Stars and Black Holes. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4937306.

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Long, Marianna M., John Bradford Bishop, Lawrence J. DeLucas, Tattanhalli L. Nagabhushan, Paul Reichert та G. David Smith. "Protein crystal growth in microgravity review of large scale temperature induction method: Bovine insulin, human insulin and human α-interferon". У AIP Conference Proceedings Volume 387. ASCE, 1997. http://dx.doi.org/10.1063/1.52064.

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J Larsson, Tore, Hedvig Aminoff, and Mannan Mridha. "A Consumers’ Testing Approach to the Usability of Medical Technology - Insulin Pumps and CGM Systems." In Applied Human Factors and Ergonomics Conference. AHFE International, 2019. http://dx.doi.org/10.54941/ahfe100156.

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Five different insulin pumps and three systems for continuous glucose monitoring were subjected to usability tests at the School of Technology and Health. Each pump was trialed and rated by 30 respondents; 20 students with no experience of diabetes and 10 diabetic pump users. Each of the CGM systems was trialed and rated by 10 non-diabetic students. All participating students were enrolled in Medical Technology (Royal Institute of Technology) or Occupational Therapy (Karolinska Institute). The technical performance of pumps and CGM systems was tested independently. The respondents handled the

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Warnken, M., U. Reitzenstein, M. Fuhrmann, P. Mayer, H. Enzmann, and K. Racke. "Characterization of Proliferative Effects of Insulin and Insulin-Like Growth Factor in Human Airway Epithelial Cells." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4982.

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Zhao, Min, Stephanie A. Amiel, Mohamed Rela, Nigel Heaton, and Guo Cai Huang. "Insulin Producing Cells Derived from Human Marrow Stromal Cells." In 2008 International Conference on Biomedical Engineering And Informatics (BMEI). IEEE, 2008. http://dx.doi.org/10.1109/bmei.2008.222.

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Gao, JianKun, and Kai Fan. "Preparation and Biological Activity of PEGylated DesB30 Human Insulin." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5516347.

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Reitzenstein, U., R. Fuhrmann, P. Mayer, H. Enzmann, K. Racke, and M. Warnken. "Characterization of Proliferative Effects of Insulin in Human Lung Fibroblasts." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3477.

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Reports on the topic "Human insulin"

1

Shi, Jinping, Feng L, Liting X, Jing L, and Xing L. Meta analysis of efficacy and safety of insulin aspart and biosynthetic human insulin in the treatment of gestational diabetes mellitus. Xi'an International Medical Center Hospital, 2021. http://dx.doi.org/10.37766/inplasy2021.7.0047.

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Silva, Rodrigo Ribeiro e., Mateus de Miranda Gauza, Julia Opolski Nunes da Silva Opolski, and Maria Eduarda Schramm Guisso. Once-Weekly Insulin Icodec vs Once-Daily Insulin Glargine U100 for Type 2 Diabetes: A Meta-analysis of Phase 2 Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.5.0102.

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Review question / Objective: To compare Once-Weekly Insulin Icodec and Once-Daily Insulin Glargine U100 in patients with Type 2 Diabetes Mellitus using oral hypoglycemic drugs in need of insulin therapy. Condition being studied: Patients with Diabetes Mellitus Type 2 using oral hypoglycemic drugs in need for basal insulin. Eligibility criteria: Inclusion in this meta-analysis was restricted to studies that met all the following criteria: (1) randomized trials; (2) comparing the use once weekly insulin icodec to once daily insulin glargine; (3) enrolling patients with type 1 or type 2 diabetes

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Gao, Hui, Chen Gong, Shi-chun Shen, et al. A systematic review on the associations between prenatal phthalate exposure and childhood glycolipid metabolism and blood pressure: evidence from epidemiological studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0111.

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Review question / Objective: The present systematic review was performed to obtain a summary of epidemiological evidence on the relationships of in utero exposure to phthalates with childhood glycolipid metabolism and blood pressure. Condition being studied: Childhood cardiovascular risk factors including blood pressure, lipid profile (e.g., triglycerides, total cholesterol, HDL−C, LDL−C) and glucose metabolism (e.g., insulin, insulin resistance, insulin sensitivity, glucose) were the interested outcomes. Eligibility criteria: In brief, epidemiological studies including cohort study, case-cont

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Plymate, Stephen R. Therapy of Prostate Cancer Using a Human Antibody Targeting the Type 1 Insulin-Like Growth Factor Receptor (IGF-IR). Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada524529.

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Sumrejkanchanakij, Piyamas, Prasit Pavasant, and Tusanee Yongchaitrakul. The influence of collagen I on Insulin-like growth factor-I induced Osteopontin expression in human periodontal ligament fibroblasts. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.14.

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Extracellular matrix and growth factors are the crucial factors that regulate healing and regenerating process in human periodontal ligament (HPDL) cells. The purpose of this study was to examine the effects of type I collagen and insulin-like growth factor-I (IGF-I) on osteopontin (OPN) expression. The data showed that OPN expression was significantly decreased when cells were cultured on collagen-coated plates. Addition of IGF-I obviously induced OPN expression only in a collagen-coated condition, suggesting an attenuation effect of IGF-I on OPN expression inhibited by type I collagen. Cells

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Barash, Itamar, and Robert E. Rhoads. Translational Mechanisms that Govern Milk Protein Levels and Composition. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7586474.bard.

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Original objectives: The long term objective of the project is to achieve higher content of protein in the milk of ruminants by modulating the translational machinery in the mammary gland. The first specific aim of the BARD proposal was to characterize responsiveness of various experimental systems to combination of lactogenic hormones and amino acids with particular emphasis on discrimination between the control of total protein synthesis and milk protein synthesis. Based on the results, we planned to proceed by characterizing the stage of protein synthesis in which the stimulation by lactoge

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Weisberg, Tracey F. The Role of Growth Hormone and Insulin-Like Growth Factor-1 in Human Breast Cancer Growth in a Mouse Xenograft Model. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada391179.

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Chansiripornchai, Piyarat, and Thanaphum Osathanon. In vitro differentiation of mesenchymal stem cells from dental and oral tissues into Islet-like cell cluster. Chulalongkorn University, 2013. https://doi.org/10.58837/chula.res.2013.93.

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Diabetes mellitus is a complicated metabolic disorder resulting in hyperglycemia and long-term complications e.g. diabetic encephalopathy and neuropathy. Treatments of diabetes and its complications have faced many obstacles. Trend of stem cells (SCs)-based therapy has been proposed as a novel approach. Though, the study using dental SCs in this regard is yet lacking. In this study, human dental pulp SCs (hDPSCs) and human periodontal ligament SCs (hPDLSCs) were employed. The results illustrated the capability of differentiation toward islet-like cells (ILCs) cluster / insulin-producing cells

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Barash, Itamar, J. Mina Bissell, Alexander Faerman, and Moshe Shani. Modification of Milk Composition via Transgenesis: The Role of the Extracellular Matrix in Regulating Transgene Expression. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570558.bard.

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Altering milk composition via transgenesis depends on three main factors. (1) The availability of an efficient regulatory sequences for targeting transgene(s) to the mammary gland; (2) a reliable in vitro model to test the expression of transgenes prior to their introduction to the animal genome; and (3) better understanding of the major factors which determine the rate of gene expression and protein synthesis. The current studies provide the necessary means and knowledge to alter milk protein composition via transgenesis. The following specific goals were achieved: a: Identifying regulatory r

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Hartings, Jed A. Spreading Depressions as Secondary Insults after Traumatic Injury to the Human Brain. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada576147.

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