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Dissertations / Theses on the topic 'Huperzina A'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Lunardi, Paula Santana. "Efeito da huperzina-A sobre a secreção de S100B em cultura primária de astrócitos e fatias hipocampais." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/27999.

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A doença de Alzheimer (DA) resulta de múltiplos eventos patogênicos, que incluem anormalidades no processamento protéico, inflamação e estresse oxidativo, levando à destruição seletiva de populações neuronais, especialmente de neurônios colinérgicos. Tal hipótese colinérgica justifica o uso de inibidores da acetilcolinesterase (AChE) como a estratégia utilizada para tratamento de pacientes com DA. Huperzina A (HupA), um alcalóide Licopodium extraído de uma espécie vegetal (Huperzia serrata) de uso tradicional pela medicina chinesa, parece se apresentar como uma alternativa. A HupA atua como um

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2

Lunardi, Paula Santana. "Perfil da ativação dos astrócitos em diferentes modelos biológicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/101643.

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Apesar de representarem cerca de 50% de todas as células do encéfalo humano, as células da glia foram negligenciadas pela Doutrina do Neurônio, no início do século XX, por não serem excitáveis e por não se comunicarem como os neurônios. Durante um longo período, os estudos sobre os astrócitos se restringiam a suas funções de suporte do SNC. Atualmente se sabe que os astrócitos expressam receptores para uma variedade de neurotransmissores, como por exemplo, receptores colinérgicos nicotínicos, sugerindo possíveis mecanismos de resposta aos sinais enviados pela atividade neuronal, de modo variáv

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3

Alcalà, Cañadas Ma del Mar. "Estudio farmacológico de nuevos anticolinesterásicos híbridos tracina-huperzina A potencialmente útiles para el tratamiento de la enfermedad de Alzheimer." Doctoral thesis, Universitat Autònoma de Barcelona, 2003. http://hdl.handle.net/10803/5374.

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La enfermedad de Alzheimer (AD) es uno de los trastornos neurodegenerativos más importantes que afectan a las personas de edad avanzada, y tan sólo los fármacos anticolinesterásicos han probado tener cierta utilidad en la terapéutica de esta enfermedad. En el presente trabajo de tesis doctoral se han evaluado diversas características farmacológicas de dos nuevos anticolinesterásicos híbridos tacrina-huperzina A, (±)-huprina Y (huprina Y) y (±)-huprina Z (huprina Z). Mediante el método de Ellman se determinó la inhibición de los enzimas acetilcolinesterasa (AChE) bovina y humana y butirilcoline

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4

Román, Mejías Susana. "Caracterización colinérgica de la (+/-) huprina x, un anticolinesterásico híbrido tacrina-huperzina A, con potencial interés para el tratamiento sintomatológico de la enfermedad de Alzheimer." Doctoral thesis, Universitat Autònoma de Barcelona, 2005. http://hdl.handle.net/10803/5398.

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La enfermedad de Alzheimer (EA) es la enfermedad neurodegenerativa más común entre las demencias existentes hoy en día, cursando con alteraciones cognitivas y neuropsiquiátricas. Durante el proceso normal de envejecimiento existe un declive de las funciones sensoriales y motoras, acompañado de una disfunción cognitiva leve. Sin embargo, la demencia comprende un grupo de disfunciones caracterizadas por un deterioro gradual de las habilidades intelectuales, hasta el punto de originar graves problemas sociales. La prevalencia de los casos de demencia en personas de más de 80 años es de aproximada

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5

Gissi, Danilo Soares. "Phylogeny of Phlegmariurus (Lycopodiaceae) focusing on Brazilian endemic species." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/41/41132/tde-18052017-150806/.

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Phlegmariurus is the most abundant genus of Lycopodiaceae in Brazil with 40 species, 24 of which are endemic, occurring mainly in the Atlantic Rainforest and Rocky Fields (“Campos Rupestres”) in the Espinhaço range. Some phylogeny works with the group had already been carried out, but not including a representative sample of the Brazilian species. Thus, we performed a molecular phylogeny of Phlegmariurus species endemic in Brazil using three molecular markers of cpDNA. Phlegmariurus showed to be monophyletic, including two clades, one Neotropical and another Paleotropical. All the

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6

Caprio, Vittorio. "A convergent approach to huperzine A." Thesis, University of Reading, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389646.

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7

Lucey, Cathal Daniel. "Synthesis of Huperzine A and analogues." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485064.

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Huperzine A is a natural product, originally isolated from the Chinese club moss Huperzia serrata, which is currently undergoing clinical trials in the U.S. and has already been approved in China for the treatment of Alzheimer's disease (AD). This sesquiterpene alkaloid of the Lycopodium family is an eXGellent selective and reversible inhibitor of acetylcholinesterase (AChE), which is an established target in the palliative treatment of AD. Huperzine A has been the target of several syntheses and a number of analogues have also been prepared. However, all of the synthetic approaches to date ha

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8

Kessler, Eduardo. "Esporófito de Huperzia mandiocana (Raddi) Trevisan (Lycopodiaceae)." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/92913.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Biologia Vegetal, Florianópolis, 2009.<br>Made available in DSpace on 2012-10-24T13:55:42Z (GMT). No. of bitstreams: 1 279704.pdf: 4386601 bytes, checksum: f87d4af2dd04f85b67a27701d8b2ddbc (MD5)<br>Lycopodiaceae inclui quatro gêneros, Huperzia distingüe-se dos outros três gêneros por apresentar, entre outras características, caules ramificados isotomicamente e esporofilos semelhantes às folhas vegetativas. Huperzia mandiocana é uma epífita ocorrente nas florestas dos Est

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9

Kelly, S. A. "A convergent approach to huperzine A and analogues." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403166.

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10

Foricher, Yann. "A convergent synthesis of the skeleton of huperzine A and analogues." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342106.

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11

Booth, Susan E. "New synthetic methods in an approach to huperzine A and B." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/34022.

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The aim of the research was to develop a flexible, stereocontrolled route to huperzine A and B and other lycopodium alkaloids. One of the main objectives was to investigate whether intramolecular radical cyclisation reactions on to carbon-nitrogen double bonds might provide a new method for the synthesis of key intermediates in the total synthesis. To this end the intramolecular cyclisation reactions of vinyl and aryl radicals on to oxime ethers have been explored and these reactions have been used to prepare a number of useful bicyclic and tricyclic carbocyclic compounds and related heterocyc

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12

SAMKAOUI, ABDESSAMAD. "Etude chimique et pharmacologique de la galanthamine et de l'huperzine a dans le traitement de la maladie d'alzheimer." Strasbourg 1, 1995. http://www.theses.fr/1995STR15005.

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13

Oluwafemi, A. J., O. Okanla, P. Camps, et al. "Evaluation of cryptolepine and huperzine derivatives as lead compounds towards new agents for the treatment of human African Trypanosomiasis." Natural Products Inc, 2009. http://hdl.handle.net/10454/4534.

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no<br>The alkaloid cryptolepine (1) and eight synthetic analogues (2-8) were assessed for in vitro activities against Trypanosoma brucei. Four of the analogues were found to be highly potent with IC50 values of less than 3 nM and three of these were assessed against T. brucei brucei infection in rats. The most effective compound was 2,7-dibromocryptolepine (7); a single oral dose of 20 mg/Kg suppressed parasitaemia and increased the mean survival time to 13.6 days compared with 8.4 days for untreated controls. In addition, four huperzine derivatives (9-12) were shown to have in vitro antitry

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14

Lim, Wei-Han. "Australasian Huperzia as potential sources of Huperzine alkaloids." 2010. http://repository.unimelb.edu.au/10187/8510.

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The Lycopodiaceae is an ancient and cosmopolitan family of fern allies that include an estimated 35 Huperzia species occurring throughout the South-East Asian and Australian region. Thirteen species naturally occur in Australia and are found mainly in the tropical rainforests of far north Queensland. Over the past decade, there has been renewed interest in Huperzia and their respective Huperzine alkaloid concentrations following the discovery of Huperzine A (HupA) and Huperzine B (HupB) alkaloids in H. serrata (Thunb. ex Murray) Trevis. Both alkaloids are of pharmaceutical interest since they

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15

Wang, ChenChung, and 王承中. "Comparison of Microwave-assisted and Ultrasonic-assisted Extraction of Huperzine A from Huperzia Serrata and Evaluation of Biological Activities of Extracts." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/03666010519511074712.

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碩士<br>大葉大學<br>生物產業科技學系<br>99<br>Base on those research in this following year, Huperzine A what we can find out in Huperzia serrata is kind of potent Acetylcholinesterase blocker; Acetylcholinesterase is the enzyme which decompose the Acetylcholine, and Acetylcholine is the Neurotransmitter of nerve function and memory working. That's why Huperzine A can help treatment the memory loss, especially the Alzheimer's disease and early symptoms of dementia. The purpose of this research is use microwave to assist the extraction method, extraction the Huperzine A inside of Huperzia serrata, and used t

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16

HUANG, HUI-QING, та 黃惠卿. "Huperzine A的合成研究". Thesis, 1990. http://ndltd.ncl.edu.tw/handle/35196776480832032755.

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碩士<br>中原大學<br>化學研究所<br>78<br>HuperzineA是由常用於中藥上的植物石松Lycopodium serratum Thunb , 分離出來的一種生物鹼。 Huperzine A 為一種乙醯膽鹼的抑制劑 (inhibitor), 在生理實驗上有顯著地抗乙醯膽鹼 (anticholinesterase) 的活性, 在動物生理實驗上, Huperzine A 對動物具有增進記憶力及學習能力的作用。目前在中國大陸對此生物鹼正進行有關因阿爾滋海默氏病 (Alzheimer'sdisease) 疾病所造成的語言障礙及嚴重的記憶力受損的臨床實驗以及因重症肌無力症 (myasthenia gravis)所造成肌肉運動後出現程度不等的無力之臨床實驗。以1, 4- 環己二酮單伸乙縮酮當起始物, 經內醯胺化得 [A], 氮- 芐基化得 [B], 芳香化得化合物 [C], 欲引進硝基, 卻得化合物 [D], 而非預期產物 [E]。使用更簡潔的方法, 一

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17

Trachtová, Pavla. "Stanovištní nároky a prediktivní modelování výskytu druhu Huperzia selago." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-332225.

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Studies of the occurrence of montane and boreomontane species in ravines of the sandstone landscape are scarce and the occurrence of these species are explained by the presence of temperature inversion. The question is, which factors limit the occurrence ofthese species in ravines with temperature inversion. The aim of this diploma thesis is to reveal factors that influence the occurrence of Huperzia selago in inverse ravines of sandstone landscape. This work uses a habitat variables recorded directly for populations of H. selago and variables derived from a digital elevation model. These deri

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18

Kim, Jungchul. "Natural product synthesis via cyclobutanes : part I, Asymmetric synthesis of (+)-byssochlamic acid, part II, An approach to the nootropic agent huperzine A." Thesis, 2000. http://hdl.handle.net/1957/32732.

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PART I. Asymmetric syntheses of both natural (+)- and nonnatural (-)- byssochlamic acid via a [2+2] photoaddition-cycloreversion strategy are described. X-ray crystallographic analysis of the cyclohexylamine salt 99 showed that the structure of the monomethyl ester 100 from esterase hydrolysis of 44 was originally misassigned as 56. The enantiomeric relationship of the two diolides 106 and 70 permitted syntheses of nonnatural byssochlamic acid (-)-3 and natural byssochiamic acid (+)-3 from enantiopure alcohol (+)-64 and from its enantiomer (-)-110, respectively. Through the use of (��)-103 to

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19

Jeffrey, Scott C. "Synthetic studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of rapamycin." Thesis, 1996. http://hdl.handle.net/1957/34483.

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