Academic literature on the topic 'LC-MS/MS detection'

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Journal articles on the topic "LC-MS/MS detection"

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Wicka, Mariola, Piotr Chołbiński, Dorota Kwiatkowska, and Andrzej Pokrywka. "Detection of psychotropic substances in the blood by LC/MS/MS." Issues of Forensic Science 284 (2014): 60–69. http://dx.doi.org/10.34836/pk.2014.284.3.

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Year on year, one can observe an increase in the use of addictive substances. This leads to occurring the problem of addiction as well as the use of psychoactive substances as a serious hazard to road users. The Regulation of the Minister of Health on agents acting similarly to alcohol and the conditions and manner of conducting research on their presence in the human body, requires adequate benchmarks for performing these tests. An importantfactor, from consultative point of view, is the knowledge of the chemical structure of substances belonging to different groups of drugs of abuse, their m
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Mohammed, Navaziya. "HPLC Hyphenations in Advanced Analytical World." Journal of Physical Chemistry & Biophysics 12, no. 2 (2022): 5. https://doi.org/10.5281/zenodo.14604252.

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Traditional analytical approaches of HPLC found to be insufficient for solving upcoming challenges in species specificity and sensitivity analysis. Modern analytical hybrid techniques which are referred as hyphenations have been introduced from the traditional techniques to overcome the challenges in the analysis of components. Hyphenated approaches combine separation and detection procedures through the use of chromatographic and spectroscopic techniques. The various hyphenations of that are developed until now are LC-MS, LC-NMR, LC-IR, LC-DAD and it also includes multi hyphenations like LC-M
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Yun, So-Mi, Jun-Ho Jang, Il-Shik Shin, Jong-Ok Lee, and Jong-Soo Lee. "Detection of Diarrhetic Shellfish Poisons by LC-MS/MS." Journal of the Korean Society of Food Science and Nutrition 36, no. 7 (2007): 926–31. http://dx.doi.org/10.3746/jkfn.2007.36.7.926.

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Chiou, Ling Jan, Tai Sheng Yeh, and Jiing Chuan Chen. "LC-MS/MS method for the detection of multiple classes of shellfish toxins." Czech Journal of Food Sciences 37, No. 3 (2019): 173–79. http://dx.doi.org/10.17221/125/2018-cjfs.

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Marine shellfish toxins are seafood safety problems of global concern. Herein the analysis of six shellfish toxins, regulated by European Union, with one single run by LC-MS/MS with acidic mobile phase was developed. After 80% methanol extraction of the shellfish toxins, the crude extract was subjected to HLB SPE cleanup before LC-MS/MS analysis. The method was validated according to Commission Decision 2002/657/EC. For azaspiracid-1 (AZA1), domoic acid (DA), dinophysistoxin-1 (DTX1), okadaic acid (OA), pectenotoxin-2 (PTX2), and yessotoxin (YTX) toxins the recovery rate was 99.4, 92.7, 114.1,
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Dello, Simon A. W. G., Hans M. H. van Eijk, Evelien P. J. G. Neis, Mechteld C. de Jong, Steven W. M. Olde Damink, and Cornelis H. C. Dejong. "Ophthalmate detection in human plasma with LC–MS–MS." Journal of Chromatography B 903 (August 2012): 1–6. http://dx.doi.org/10.1016/j.jchromb.2012.06.023.

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Krajčová, A., V. Schulzová, J. Lojza, L. Křížová, and J. Hajšlová. "Phytoestrogens in bovine plasma and milk – LC-MS/MS analysis." Czech Journal of Food Sciences 28, No. 4 (2010): 264–74. http://dx.doi.org/10.17221/138/2010-cjfs.

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Phytoestrogens belong to a group of polyphenolic plant metabolites which induce biological responses, based on their structural similarity to 17β-estradiol. In order to investigate the relationship between the levels of these biologically active compounds and beneficial health effects, it is neccesary to quantify accurately their levels in foods and biological fluids. In this study, HPLC-MS/MS method for the determination of isoflavones genistein, daidzein, and estrogenic metabolite-equol in bovine plasma and milk was optimised and validated. The method allowed low limits of detection
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Kahl, Kristin W., Joshua Z. Seither, and Lisa J. Reidy. "LC-MS-MS vs ELISA: Validation of a Comprehensive Urine Toxicology Screen by LC-MS-MS and a Comparison of 100 Forensic Specimens." Journal of Analytical Toxicology 43, no. 9 (2019): 734–45. http://dx.doi.org/10.1093/jat/bkz066.

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Abstract Toxicology laboratories commonly employ immunoassay methodologies to perform an initial drug screen on urine specimens to direct confirmatory testing. Due to limitations of immunoassay testing and the need to screen for a broader range of drugs with lower limits of detection at a lower cost, mass spectrometry screening techniques have gained favor in the toxicology field. A liquid chromatography–tandem mass spectrometry (LC-MS-MS) urine screening panel was developed and validated for 52 drugs and metabolites. A simple dilute-and-shoot with enzymatic hydrolysis technique was utilized t
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Esquivel, Argitxu, Oscar J. Pozo, Lorena Garrostas, et al. "LC-MS/MS detection of unaltered glucuronoconjugated metabolites of metandienone." Drug Testing and Analysis 9, no. 4 (2016): 534–44. http://dx.doi.org/10.1002/dta.1996.

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Downs, Melanie L., and Philip Johnson. "Target Selection Strategies for LC-MS/MS Food Allergen Methods." Journal of AOAC INTERNATIONAL 101, no. 1 (2018): 146–51. http://dx.doi.org/10.5740/jaoacint.17-0404.

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Abstract The detection and quantitation of allergens as contaminants in foods using MS is challenging largely due to the requirement to detect proteins in complex, mixed, and often processed matrixes. Such methods necessarily rely on the use of proteotypic peptides as indicators of the presence and amount of allergenic foods. These peptides should represent the allergenic food in question in such a way that their use is both sensitive (no false-negatives) and specific (no false-positives). Choosing such peptides to represent food allergens is beset with issues, including, but not limited to, s
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Weinmann, W., M. Bohnert, A. Wiedemann, M. Renz, N. Lehmann, and S. Pollak. "Post-mortem detection and identification of sildenafil (Viagra) and its metabolites by LC/MS and LC/MS/MS." International Journal of Legal Medicine 114, no. 4-5 (2001): 252–58. http://dx.doi.org/10.1007/s004140000178.

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Dissertations / Theses on the topic "LC-MS/MS detection"

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Wong, Chun-kit Jack. "Application of immunochemical and LC/MS/MS techniques in the detection of sulfonamide residues in livestock /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36886294.

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Gómez, Castellà Cristina 1985. "Improving detection capabilities of doping agents by identification of new phase I and phase II metabolites by LC-MS/MS." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/132539.

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Metabolic studies of doping agents have been traditionally performed by using gas chromatography coupled to mass spectrometry (GC-MS). In the last years, liquid chromatography coupled to mass spectrometry (LC-MS) has demonstrated to offer new possibilities to perform metabolic studies. The objective of this thesis was to study the metabolism (phase I and phase II) of different doping agents by LC-MS/MS in order to improve the detection capabilities of the studied substances. For mesocarb, a thermolabile compound, the parent drug 19 metabolites were detected in urine including mono-, di- and t
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Planinc, Ana. "Detection of changes in n-glycosylation profiles of therapeutic glycoproteins using LC-MS." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/241427/4/Table.pdf.

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Biopharmaceuticals are becoming one of the most promising drugs on the market mainly due to their successful treatment of a vast array of serious diseases, such as cancers, immune disorders, and infections. Structurally, biopharmaceuticals are proteins and it is important to mention that more than 60 % of biopharmaceuticals are glycosylated. Glycosylation is one of the most common posttranslational modifications. It is also the most demanding and the most complex posttranslational modification. The research showed that glycosylation can significantly impact on the safety, efficiency, and quali
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Jora, Manasses. "Higher-energy Collisional Dissociation (HCD) as a Complementary Tool for Expanding the Detection and Discovery of Modified Ribonucleosides by LC-MS/MS." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613747846885246.

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Alberts, P. "Development of a novel LC-MS/MS method for the detection of adulteration of South African sauvignon blanc wines with 3-alkyl-2-methoxypyrazines." Thesis, Link to the Internet, 2008. http://hdl.handle.net/10019/805.

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Methling, Maximilian [Verfasser]. "Detection of psychoactive substances (antidepressants, antipsychotics, benzodiazepines, alcohol) in human hair and other matrices using liquid chromatography-mass spectrometry (LC-MS/MS) / Maximilian Methling." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1217251324/34.

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Strayer, Kraig Edward. "A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL-1 Concentrations." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1527173022936317.

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NOBILE, MARIA. "DEVELOPMENT AND VALIDATION OF METHODS FOR THE DETECTION OF RESIDUES IN UNCONVENTIONAL AND INNOVATIVE MATRICES THROUGH LC-MS/MS ANALYSES FOR SAFETY OF FOOD OF ANIMAL ORIGIN." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/547683.

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Successful animal growth depends on a combination of many factors related to health, management and nutrition. The use of veterinary drugs in food-producing animals for therapeutic purposes is regulated (corticosteroids, antibiotics) or banned (anabolic steroids) in the European Union; however, their use as growth promoters cannot be excluded. Moreover, the eventual presence of residues in food constitutes a fraud and a health issue for the consumers. For these reasons the need to find new accumulation matrices and new sensitive, specific and robust methods that are able to reveal the presence
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Wei, Li. "Part I: Oxidative Modification of Ethanolamine Phospholipids by Isolevuglandins: Detection by LC-MS/MS in Vitro and in Vivo Part II: Total Synthesis of C22-11-isolevuglandin E4." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1251210773.

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Carlin, Michelle. "Development and evaluation of an LC-ESI-MS method for the simultaneous detection of five major opium alkaloids." Thesis, Northumbria University, 2015. http://nrl.northumbria.ac.uk/27317/.

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The aim of this work was to establish an analytical method for the simultaneous detection of five major opium alkaloids in poppy seeds by liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS). Once opium alkaloids were detected in poppy seeds, toxicological studies were carried out to establish if these compounds were detected in oral fluid (OF) of participants who ingested muffins containing poppy seeds. It is known that the ingestion of poppy seeds has caused positive opiate drug test results and much work has been reported in the scientific literature in the last 20 ye
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Books on the topic "LC-MS/MS detection"

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Ng, Gary. Organic gunshot residue analysis of shooting individuals using LC/MS-MS detection. 2008.

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Book chapters on the topic "LC-MS/MS detection"

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Xia, Yuan-Qing, and Jeffrey D. Miller. "LC-MS Method Development Strategies for Enhancing Mass Spectrometric Detection." In Handbook of LC-MS Bioanalysis. John Wiley & Sons Inc., 2013. http://dx.doi.org/10.1002/9781118671276.ch31.

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Middleberg, Robert A., and Joseph Homan. "LC-MS/MS Method for the Detection of Common Laxatives." In Methods in Molecular Biology. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-934-1_14.

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Radhamanalan, Guhanraj, and D. Dhanasekaran. "Extraction and Quantification of Nodularins from Fish Samples by LC-MS/MS." In Protocols for Cyanobacteria Sampling and Detection of Cyanotoxin. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-4514-6_41.

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Beaula, Sharon, Manigundan Kaari, Ramesh Kumar, et al. "Extraction and Quantification of Saxitoxins from Aquatic Samples by LC-MS/MS." In Protocols for Cyanobacteria Sampling and Detection of Cyanotoxin. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-4514-6_45.

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Rani, Simran, Priyanka Dahiya, Chetna Rathi, et al. "Detection of Foodborne Gram-Positive Bacterial Toxins by LC-MS/MS MRM." In Methods and Protocols in Food Science. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4382-2_14.

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Swedha, A., G. Kanimozhi, and A. Panneerselvam. "Detection of Anatoxins from Aquatic Samples by LC-MS." In Protocols for Cyanobacteria Sampling and Detection of Cyanotoxin. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-4514-6_47.

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Djukovic, Danijel, Jiangjiang Zhang, and Daniel Raftery. "Colorectal Cancer Detection Using Targeted LC-MS Metabolic Profiling." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7765-9_15.

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Varghese, Rency S., and Habtom W. Ressom. "LC-MS Data Analysis for Differential Protein Expression Detection." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-977-2_10.

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Markham, Jonathan E. "Detection and Quantification of Plant Sphingolipids by LC-MS." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-401-2_10.

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Zhao, Yi, Tsung-Heng Tsai, Cristina Di Poto, Lewis K. Pannell, Mahlet G. Tadesse, and Habtom W. Ressom. "Variability Assessment of Label-Free LC-MS Experiments for Difference Detection." In Statistical Analysis of Proteomics, Metabolomics, and Lipidomics Data Using Mass Spectrometry. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-45809-0_9.

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Conference papers on the topic "LC-MS/MS detection"

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Jia, Xiaotian, Nan Liu, and Hao Jing. "Research on LC-MS Peptide Feature Detection Models Based on Deep Learning." In 2025 IEEE International Conference on Electronics, Energy Systems and Power Engineering (EESPE). IEEE, 2025. https://doi.org/10.1109/eespe63401.2025.10987164.

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Jackson, Tracey, and Jonathan Vargas. "Selective Loss of Bulk Corrosion Inhibitor Species When Exposed to Glass, Plastic, and Steel." In CORROSION 2020. NACE International, 2020. https://doi.org/10.5006/c2020-14999.

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Abstract Despite the widespread use of corrosion inhibitors (CIs) in the oil and gas industry much of their complex aggregation and adsorption behavior is still very poorly understood. CIs are surface active species meaning that when they are injected into aqueous solutions they naturally aggregate and migrate to gas-liquid, liquid-liquid, and solid-liquid interfaces. A better understanding of each CI component and how it adsorbs when exposed to various surfaces could lead to improved CI design, higher performance at lower dosages, as well as improved methods for residual detection. This paper
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Korpi-Steiner, NL, JB Hagan, BC Netzel, JC Seegmiller, and RJ Singh. "Detection of Fluticasone-17beta-Carboxylic Acid in Urine by LC-MS/MS." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1090.

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Iancu, Vasile Ion. "SPE-LC-MS/MS DETECTION OF PHARMACEUTICAL COMPOUNDS (GASTRIC ANTACIDES) IN WASTEWATER." In International Symposium "The Environment and the Industry". National Research and Development institute for Industrial Ecology, 2023. http://dx.doi.org/10.21698/simi.2023.ab33.

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Chiriac, Florentina Laura, Florinela Pirvu, Iuliana Paun, Antonia Ioana Cimpean, and Vasile Ion Iancu. "Detection and quantification of PFAS contamination in water: advancements in LC-MS/MS methodology." In International Symposium "The Environment and the Industry". National Research and Development Institute for Industrial Ecology, 2024. http://dx.doi.org/10.21698/simi.2024.ab20.

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Iwamoto, Noriko, Yuriko Minegishi, Koji Ueda, et al. "142 Detection of KRAS G12D/G12V neoepitopes expressed by cancer cell lines using LC-MS/MS." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0142.

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Tang, Weiming, Shuxiang Sun, Minghong Jia, et al. "Detection of 10 kind of pesticides multi-residue in fruits and vegetables by LC-MS/MS." In 2016 6th International Conference on Machinery, Materials, Environment, Biotechnology and Computer. Atlantis Press, 2016. http://dx.doi.org/10.2991/mmebc-16.2016.246.

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Aldegunde-Louzao, Natalia, Manuel Lolo-Aira, and Carlos Herrero-Latorre. "Fast Phthalate Detection in Textile Samples: A LC-MS/MS Screening Method Using Precursor Ion Scans." In ECSOC 2024. MDPI, 2024. https://doi.org/10.3390/ecsoc-28-20150.

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Magni, Paola. "Entomotoxicology: Development and validation of CG-MS and LC/MS-MS methods for nicotine, metanfetamine, endosulfan, and coumatetraryl detection in blowflies." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94572.

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SILVA, Bruno Pereira da, Gabriel RÜBENSAM, Claudiela Wachholz SAAFELD, and João Batista Blessmann WEBER. "RELEASE PROFILE OF BISPHENOL-A FROM DENTAL RESINS IN WATER ASSESSED BY LC-MS/MS." In SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 2021 INTERNATIONAL VIRTUAL CONFERENCE. DR. D. SCIENTIFIC CONSULTING, 2022. http://dx.doi.org/10.48141/sbjchem.21scon.23_abstract_rubensan.pdf.

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Dental resins have been designed to replace amalgam restorations due to their more favorable physical, chemical, and biological properties. However, depending on its composition, the efficiency of its polymerization, and the degradation of the polymer matrix, Bisphenol-A can be present and therefore released from this material to the human body. It has been reported that residues of additives and minority by-products of polymer reactions, such as Bisphenol-A, can be released from plastics into aqueous media through polymer hydration, water-polymer diffusion, residue dissolution, and equilibriu
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Reports on the topic "LC-MS/MS detection"

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Lehotay, Steven J., and Aviv Amirav. Fast, practical, and effective approach for the analysis of hazardous chemicals in the food supply. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7695587.bard.

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Background to the topic: For food safety and security reasons, hundreds of pesticides, veterinary drugs, and environmental pollutants should be monitored in the food supply, but current methods are too time-consuming, laborious, and expensive. As a result, only a tiny fraction of the food is tested for a limited number of contaminants. Original proposal objectives: Our main original goal was to develop fast, practical, and effective new approaches for the analysis of hazardous chemicals in the food supply. We proposed to extend the QuEChERS approach to more pesticides, veterinary drugs and pol
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อุดมกาญจนนันท์, พรพรรณ, та สุชาดา จูอนุวัฒนกุล. การตรวจวิเคราะห์สารมาลาไคต์กรีนและเมตะบอไลต์ลิวโคมาลาไคต์กรีนตกค้างในสัตว์น้ำเพาะเลี้ยงด้วยเทคนิค LC-MS/MS และเทคนิค HPLC-UV-VISIBLE : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2007. https://doi.org/10.58837/chula.res.2007.57.

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งานวิจัยนี้ได้พัฒนาวิธีวิเคราะห์MG และ LMG พร้อมกันในตัวอย่างสัตว์น้ำเพาะเลี้ยง ให้มีความถูกต้องแม่นยำสูง ด้วยการเตรียมตัวอย่างที่มีขึ้นตอนงายและรวดเร็วขึ้น ใช้เตาอบไมโครเวฟในการสกัดและคลีนอัพ และวิเคราะห์ MG และ LMG ด้วยเทคนิค LC-MS/MS มีสารคริสตัลไวโอเล็ต (Crystal violet, CV) เป็น internal standard ที่ ionpairs ดังนี้ : MG 329.3/208.2, 329.3/313.1, LMG331.3/165.4, 331.3/239.3 และ CV (internal standard) 372.2/356.3 วิธีวิเคราะห์อีกวิธีหนึ่งคือการตรวจวิเคราะห์มาลาไคต์กรีน ลิวโคมาลาไคต์กรีน คริสตัลไวโอเล็ต ลิวโคคริสตัลไวโอเล็ต ตกค้างในสัตว์น้ำเพาะเลี้ยง เช่น ปลา กุ้ง พร้อมกันด้วยเทคนิค HPLC-DAD
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Williams, A., and A. Vu. Extraction of O-isobutyl S-(2-diethylaminoethyl)methyl phosphothioate (Russian VX) and related chemical signatures from liquid eggs and analysis by Liquid Chromatography with Detection by Mass Spectrometry (LC-MS) and Gas Chromatography with Detection by. Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1078542.

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Williams, A., and A. Vu. Extraction of O-isobutyl S-(2-diethylaminoethyl)methyl phosphothioate (Russian VX) and related chemical signatures from hot dogs and analysis by Liquid Chromatography with Detection by Mass Spectrometry (LC-MS) and Gas Chromatography with Detection by Mas. Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1090025.

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อุดมกาญจนนันท์, พรพรรณ, та สุชาดา จูอนุวัฒนกุล. การตรวจวิเคราะห์สารมาลาไคต์กรีนและเมตะบอไลต์ลิวโคมาลาไคต์กรีนตกค้าง ในสัตว์น้ำเพาะเลี้ยง ด้วยเทคนิค LC-MS/MS และเทคนิค HPLC-UV-VISIBLE : รายงานการวิจัยฉบับสมบูรณ์. คณะวิทยาศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2008. https://doi.org/10.58837/chula.res.2008.37.

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งานวิจัยนี้ได้พัฒนาวิธีวิเคราะห์ MG และ LMG พร้อมกันในตัวอย่างสัตว์น้ำเพาะเลี้ยง ให้มีความถูกต้องแม่นยำสูง ด้วยการเตรียมตัวอย่างที่มีขั้นตอนง่ายและรวดเร็วขึ้น ใช้เตาอบไมโครเวฟ ในการสกัดและคลีนอัพ และวิเคราะห์ MG และ LMG ด้วยเทคนิค LC-MS/MS มีสารคริสตัลไวโอเล็ต (Crystal violet, CV) เป็น internal standard ที่ ion pairs ดังนี้ : MG 329.3/208.2, 329.3/313.1, LMG 331 .3/165.4, 331.3/239.3 และ CV (internal standard) 372.2/356.3 วิเคราะห์ปริมาณด้วยวิธี standard addition method ร่วมกับ internal standard calibration method วิธีวิเคราะห์อีกวิธีหนึ่งคือการวิเคราะห์มาลาไคต์กรีน ลิวโคมาลาไคด์กรีน คริสตัลไว
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Fluhr, Robert, and Maor Bar-Peled. Novel Lectin Controls Wound-responses in Arabidopsis. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7697123.bard.

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Abstract:
Innate immune responses in animals and plants involve receptors that recognize microbe-associated molecules. In plants, one set of this defense system is characterized by large families of TIR–nucleotide binding site–leucine-rich repeat (TIR-NBS-LRR) resistance genes. The direct interaction between plant proteins harboring the TIR domain with proteins that transmit and facilitate a signaling pathway has yet to be shown. The Arabidopsis genome encodes TIR-domain containing genes that lack NBS and LRR whose functions are unknown. Here we investigated the functional role of such protein, TLW1 (TI
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