Academic literature on the topic 'Lipooligosaccharide'

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Journal articles on the topic "Lipooligosaccharide"

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Houliston, R. Scott, Evgeny Vinogradov, Monika Dzieciatkowska, Jianjun Li, Frank St. Michael, Marie-France Karwaski, Denis Brochu, et al. "Lipooligosaccharide ofCampylobacter jejuni." Journal of Biological Chemistry 286, no. 14 (January 21, 2011): 12361–70. http://dx.doi.org/10.1074/jbc.m110.181750.

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Sun, Shuhua, N. Karoline Scheffler, Bradford W. Gibson, Jing Wang, and Robert S. Munson. "Identification and Characterization of the N-Acetylglucosamine Glycosyltransferase Gene of Haemophilus ducreyi." Infection and Immunity 70, no. 10 (October 2002): 5887–92. http://dx.doi.org/10.1128/iai.70.10.5887-5892.2002.

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ABSTRACT Haemophilus ducreyi is the causative agent of chancroid, a sexually transmitted ulcerative disease. In the present study, the Neisseria gonorrhoeae lgtA lipooligosaccharide glycosyltransferase gene was used to identify a homologue in the genome of H. ducreyi. The putative H. ducreyi glycosyltransferase gene (designated lgtA) was cloned and insertionally inactivated, and an isogenic mutant was constructed. Structural studies demonstrated that the lipooligosaccharide isolated from the mutant strain lacked N-acetylglucosamine and distal sugars found in the lipooligosaccharide produced by
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Pollard, Angela, Frank St. Michael, Lynn Connor, Wade Nichols, and Andrew Cox. "Structural characterization of Haemophilus parainfluenzae lipooligosaccharide and elucidation of its role in adherence using an outer core mutant." Canadian Journal of Microbiology 54, no. 11 (November 2008): 906–17. http://dx.doi.org/10.1139/w08-082.

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The opportunistic pathogen Haemophilus parainfluenzae is a gram-negative bacterium found in the oropharynx of humans. Haemophilus parainfluenzae is a member of the Pasteurellaceae family in which it is most closely related to Haemophilus sengis and Actinobacillus . Characterization of surface displayed lipooligosaccharide has identified components that are crucial in adherence. We examined the oligosaccharide structure of lipooligosaccharide from 2 clinical isolates of H. parainfluenzae. Core oligosaccharide was isolated by standard methods from purified lipooligosaccharide. Structural informa
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Corsaro, M. Michela, Rosa Lanzetta, Ermenegilda Parrilli, Michelangelo Parrilli, M. Luisa Tutino, and Salvatore Ummarino. "Influence of Growth Temperature on Lipid and Phosphate Contents of Surface Polysaccharides from the Antarctic Bacterium Pseudoalteromonas haloplanktis TAC 125." Journal of Bacteriology 186, no. 1 (January 1, 2004): 29–34. http://dx.doi.org/10.1128/jb.186.1.29-34.2004.

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ABSTRACT The chemical structural variations induced by different growth temperatures in the lipooligosaccharide and exopolysaccharide components extracted from the Antarctic bacterium Pseudoalteromonas haloplanktis TAC 125 are described. The increase in phosphorylation with the increase in growth temperature seems to be general, because it happens not only for the lipooligosaccharide but also for the exopolysaccharide. Structural variations in the lipid components of lipid A also occur. In addition, free lipid A is found at both 25 and 4°C but not at 15°C, which is the optimal growth temperatu
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Greiner, L. L., H. Watanabe, N. J. Phillips, J. Shao, A. Morgan, A. Zaleski, B. W. Gibson, and M. A. Apicella. "Nontypeable Haemophilus influenzae Strain 2019 Produces a Biofilm Containing N-Acetylneuraminic Acid That May Mimic Sialylated O-Linked Glycans." Infection and Immunity 72, no. 7 (July 2004): 4249–60. http://dx.doi.org/10.1128/iai.72.7.4249-4260.2004.

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ABSTRACT Previous studies suggested that nontypeable Haemophilus influenzae (NTHI) can form biofilms during human and chinchilla middle ear infections. Microscopic analysis of a 5-day biofilm of NTHI strain 2019 grown in a continuous-flow chamber revealed that the biofilm had a diffuse matrix interlaced with multiple water channels. Our studies showed that biofilm production was significantly decreased when a chemically defined medium lacking N-acetylneuraminic acid (sialic acid) was used. Based on these observations, we examined mutations in seven NTHI strain 2019 genes involved in carbohydra
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Starner, Timothy D., W. Edward Swords, Michael A. Apicella та Paul B. McCray. "Susceptibility of Nontypeable Haemophilus influenzae to Human β-Defensins Is Influenced by Lipooligosaccharide Acylation". Infection and Immunity 70, № 9 (вересень 2002): 5287–89. http://dx.doi.org/10.1128/iai.70.9.5287-5289.2002.

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ABSTRACT Nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide htrB mutants exhibited greater than 45-fold-increased sensitivity to human β-defensin 2 (HBD-2) compared to the wild type. Complementation by htrB in trans to acylation competence reversed this increased sensitivity. In contrast, NTHI was more susceptible to HBD-3 and showed no changes in sensitivity as a result of lipooligosaccharide mutations in oligosaccharide and lipid A biosynthesis genes.
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Lewis, Lisa A., Biswa Choudhury, Jacqueline T. Balthazar, Larry E. Martin, Sanjay Ram, Peter A. Rice, David S. Stephens, Russell Carlson, and William M. Shafer. "Phosphoethanolamine Substitution of Lipid A and Resistance of Neisseria gonorrhoeae to Cationic Antimicrobial Peptides and Complement-Mediated Killing by Normal Human Serum." Infection and Immunity 77, no. 3 (December 29, 2008): 1112–20. http://dx.doi.org/10.1128/iai.01280-08.

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ABSTRACT The capacity of Neisseria gonorrhoeae to cause disseminated gonococcal infection requires that such strains resist the bactericidal action of normal human serum. The bactericidal action of normal human serum against N. gonorrhoeae is mediated by the classical complement pathway through an antibody-dependent mechanism. The mechanism(s) by which certain strains of gonococci resist normal human serum is not fully understood, but alterations in lipooligosaccharide structure can affect such resistance. During an investigation of the biological significance of phosphoethanolamine extensions
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Grenier, Daniel. "Binding properties of Treponema denticola lipooligosaccharide." Journal of Oral Microbiology 5, no. 1 (January 1, 2013): 21517. http://dx.doi.org/10.3402/jom.v5i0.21517.

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Arking, Dan, Yanhong Tong, and Daniel C. Stein. "Analysis of Lipooligosaccharide Biosynthesis in theNeisseriaceae." Journal of Bacteriology 183, no. 3 (February 1, 2001): 934–41. http://dx.doi.org/10.1128/jb.183.3.934-941.2001.

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ABSTRACT Neisserial lipooligosaccharide (LOS) contains three oligosaccharide chains, termed the α, β, and γ chains. We used Southern hybridization experiments on DNA isolated from variousNeisseria spp. to determine if strains considered to be nonpathogenic possessed DNA sequences homologous with genes involved in the biosynthesis of these oligosaccharide chains. The presence or absence of specific genes was compared to the LOS profiles expressed by each strain, as characterized by their mobilities on sodium dodecyl sulfate-polyacrylamide gel electrophoresis gel and their reactivities with vari
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Parker, Craig T., Michel Gilbert, Nobuhiro Yuki, Hubert P. Endtz, and Robert E. Mandrell. "Characterization of Lipooligosaccharide-Biosynthetic Loci of Campylobacter jejuni Reveals New Lipooligosaccharide Classes: Evidence of Mosaic Organizations." Journal of Bacteriology 190, no. 16 (June 13, 2008): 5681–89. http://dx.doi.org/10.1128/jb.00254-08.

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ABSTRACT The lipooligosaccharide (LOS) biosynthesis region is one of the more variable genomic regions between strains of Campylobacter jejuni. Indeed, eight classes of LOS biosynthesis loci have been established previously based on gene content and organization. In this study, we characterize additional classes of LOS biosynthesis loci and analyze various mechanisms that result in changes to LOS structures. To gain further insights into the genomic diversity of C. jejuni LOS biosynthesis region, we sequenced the LOS biosynthesis loci of 15 strains that possessed gene content that was distinct
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Dissertations / Theses on the topic "Lipooligosaccharide"

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Howard, Michael David. "Antigenic Characterization of Haemophilus somnus Lipooligosaccharide." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/35378.

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<P>Lipooligosaccharide (LOS) is the major outer membrane component of many Gram-negative bacteria inhabiting the mucosal membranes, including pathogenic species of <I>Haemophilus</I> and <I>Neisseria</I>. LOS phase variation is one mechanism by which some of these bacteria avoid the host immune response. To better understand LOS phase variation as a virulence mechanism of <I>H. somnus</I>, knowledge of the antigenic diversity of LOS epitopes must be increased. Monoclonal antibodies (MAbs) to <I>H. somnus</I> LOS were produced and used with cross-reacting MAbs to <I>H. aegyptius</I> LOS (MAb
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Tu, Mai H. "Lipooligosaccharide-modified polymeric particles for targeted pulmonary drug delivery." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5666.

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Targeted delivery of drugs directly to the lung epithelium is a promising, though challenging, strategy for the treatment of diseases that affect the lung tissues, such as infections caused by cell-penetrating pathogens, cystic fibrosis, and cancer. With appropriate surface functionality, such as through the attachment of ligands that recognize receptors on cellular surfaces, particulate carriers show improved efficiency in penetrating cells in vitro. A useful class of ligands is produced by many natural human pathogens that infect the respiratory tract. A variety of phylogenetically distinct
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Pollard, Angela M. Nichols Wade. "Haemophilus parainfluenzae lipooligosaccharide analysis of structure, toxicity, and role in colonization /." Normal, Ill. : Illinois State University, 2005. http://wwwlib.umi.com/cr/ilstu/fullcit?p3196641.

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Thesis (Ph. D.)--Illinois State University, 2005.<br>Title from title page screen, viewed September 27, 2006. Dissertation Committee: Wade Nichols (chair), Jon Friesen, Craig Gatto, Laura Vogel, Brian Wilkinson. Includes bibliographical references (leaves 87-93) and abstract. Also available in print.
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O'Connor, Ellen Therese. "What makes a pathogen? genetic and structural heterogeneity of neisserial lipooligosaccharide /." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/3359.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2006.<br>Thesis research directed by: Cell Biology & Molecular Genetics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Millar, Lorna Anne. "Diversity and function of the lipooligosaccharide biosynthesis genes from Campylobacter jejuni." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/30348.

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The enteric pathogen, Campylobacter jejuni, produces a range of LOS structures, however, the precise functions of LOS molecules in infection are largely undetermined. LOS structural diversity is known to arise from variation in LOS biosynthesis gene content and gene sequence. In determining the extent of LOS biosynthesis gene content variation in a group of mainly clinical C. jejuni isolates, in this study two new clusters of LOS biosynthesis genes have been identified. The C. jejuni LOS core can also undergo phase variation due to the presence of GC homopolymeric tracts in the protein coding
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Chakraborti, Srinjoy. "Therapeutic Antibody Against Neisseria gonorrhoeae Lipooligosaccharide, a Phase-variable Virulence Factor." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/905.

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Neisseria gonorrhoeae (Ng) which causes gonorrhea has become multidrug-resistant, necessitating the development of novel therapeutics and vaccines. mAb 2C7 which targets an epitope within an important virulence factor, the lipooligosaccharide (LOS), is a candidate therapeutic mAb. Ninety-four percent of clinical isolates express the 2C7-epitope which is also a vaccine target. Ng expresses multiple LOS(s) due to phase-variation (pv) of LOS glycosyltransferase (lgt) genes. mAb 2C7 reactivity requires a lactose extension from the LOS core Heptose (Hep) II (i.e. lgtG ‘ON’ [G+]). Pv results in HepI
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Sun, Shuhua. "Cloning and characterization of lipooligosaccharide (LOS) biosynthetic genes of Haemophilus ducreyi /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488205318509985.

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Chakraborti, Srinjoy. "Therapeutic Antibody Against Neisseria gonorrhoeae Lipooligosaccharide, a Phase-variable Virulence Factor." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/905.

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Neisseria gonorrhoeae (Ng) which causes gonorrhea has become multidrug-resistant, necessitating the development of novel therapeutics and vaccines. mAb 2C7 which targets an epitope within an important virulence factor, the lipooligosaccharide (LOS), is a candidate therapeutic mAb. Ninety-four percent of clinical isolates express the 2C7-epitope which is also a vaccine target. Ng expresses multiple LOS(s) due to phase-variation (pv) of LOS glycosyltransferase (lgt) genes. mAb 2C7 reactivity requires a lactose extension from the LOS core Heptose (Hep) II (i.e. lgtG ‘ON’ [G+]). Pv results in HepI
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Phongsisay, Vongsavanh, and vongsavang@yahoo com au. "Campylobacter jejuni and the Guillain-Barré syndrome." RMIT University. Applied Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20061221.100446.

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Campylobacter jejuni is an enteric bacterium that causes human gastroenteritis worldwide. Some C. jejuni strains exhibiting human ganglioside-like lipooligosaccharide (LOS) structures, such as GM1 ganglioside, can induce an autoimmune neuropathy of the peripheral nervous system known as the Guillain-Barré syndrome (GBS). This GBS-inducible determinant is encoded by a gene cluster, which shows a high degree of variation among C. jejuni strains. The experiments presented in this thesis were conducted to give a better insight into the LOS synthesis genes in relation to the patho
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Lodge, Karen, and karen lodge@rmit edu au. "A Molecular Investigation of Campylobacter jejuni Pathogenesis." RMIT University. Applied Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080229.151747.

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Campylobacter jejuni is one of the leading bacterial causes of human gastroenteritis world wide and has been linked to several severe complications including autoimmune syndromes which can result in paralysis. Despite being the subject of much study, C. jejuni remains a major public health burden in both developing and developed nations. There is currently no vaccine available for protection against this pathogen and the mechanisms important for C. jejuni pathogenesis are not fully defined. This study has employed a range of experimental approaches to investigate the molecular me
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Books on the topic "Lipooligosaccharide"

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Mandrell, Robert Earl. Sialylation of the lipooligosaccharides of neisseria. Birmingham: University of Birmingham, 1992.

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Book chapters on the topic "Lipooligosaccharide"

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Christodoulides, Myron. "Preparation of Lipooligosaccharide (LOS) from Neisseria gonorrhoeae." In Neisseria gonorrhoeae, 87–96. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9496-0_6.

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Densen, P., W. D. Zollinger, S. Gulati, and P. A. Rice. "Antibodies against Neisseria gonorrhoeae lipooligosaccharide antigens stimulate neutrophil chemotaxis." In Gonococci and Meningococci, 511–18. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-009-1383-7_80.

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Petrov, A. B., B. F. Semenov, Yu P. Vartanyan, V. P. Torchilin, V. S. Trubetskoy, N. V. Koshkina, B. A. Dmitriev, V. L. L’vov, and I. V. Lopyrev. "Development of Liposomal Vaccine on the Basis of Neisseria meningitidis Lipooligosaccharide." In Neisseriae 1990, edited by Mark Achtman, Peter Kohl, Christian Marchal, Giovanna Morelli, Andrea Seiler, and Burghard Thiesen, 259–64. Berlin, Boston: De Gruyter, 1991. http://dx.doi.org/10.1515/9783110867787-048.

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Apicella, M. A., M. Shero, G. A. Jarvis, J. M. Griffiss, Robert E. Mandrell, and H. Schneider. "Phenotypic variation of the antigen expression of the lipooligosaccharide of Neisseria gonorrhoeae." In Gonococci and Meningococci, 477–83. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-009-1383-7_75.

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Inzana, Thomas J. "The Many Facets of Lipooligosaccharide as a Virulence Factor for Histophilus somni." In Current Topics in Microbiology and Immunology, 131–48. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/82_2015_5020.

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Semenov, B. F., A. B. Petrov, T. A. Chulok, V. P. Torchilin, V. S. Trubetskoy, N. V. Koshkina, V. T. Ivanov, T. M. Andronova, and B. B. Ivanov. "Immunomodulating Complex of Oligopeptide Antigen and Liposomal Form of Neisseria meningitidis Lipooligosaccharide." In Neisseriae 1990, edited by Mark Achtman, Peter Kohl, Christian Marchal, Giovanna Morelli, Andrea Seiler, and Burghard Thiesen, 277–82. Berlin, Boston: De Gruyter, 1991. http://dx.doi.org/10.1515/9783110867787-051.

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Hammack, C. A., J. McLeod Griffiss, M. A. Apicella, and H. Schneider. "Spontaneous variation of lipooligosaccharide components and epitopes in a strain of Neisseria gonorrhoeae." In Gonococci and Meningococci, 537–41. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-009-1383-7_84.

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Kim, J. J., R. E. Mandrell, Hu Zhen, J. T. Poolman, and J. McLeod Griffiss. "Monoclonal antibody identification of shared lipooligosaccharide epitopes of Neisseria meningitidis and Neisseria lactamica." In Gonococci and Meningococci, 563–67. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-009-1383-7_88.

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Stein, Daniel C., and Emanuel F. Petricoin. "Regulation of the addition of 0-side chains on lipooligosaccharide in Neisseria gonorrhoeae." In Neisseriae 1990, edited by Mark Achtman, Peter Kohl, Christian Marchal, Giovanna Morelli, Andrea Seiler, and Burghard Thiesen, 385–90. Berlin, Boston: De Gruyter, 1991. http://dx.doi.org/10.1515/9783110867787-069.

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Dudas, K. C., M. B. Nelson, P. T. LoVerde, and M. A. Apicella. "Pseudomonas pyocin and Neisseria gonorrhoeae: Investigations into the mechanism of gonococcal lipooligosaccharide variant selection." In Neisseriae 1990, edited by Mark Achtman, Peter Kohl, Christian Marchal, Giovanna Morelli, Andrea Seiler, and Burghard Thiesen, 343–48. Berlin, Boston: De Gruyter, 1991. http://dx.doi.org/10.1515/9783110867787-062.

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Conference papers on the topic "Lipooligosaccharide"

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Griffiss, Mac. "P678 An effective gonococcal lipooligosaccharide (LOS) vaccine: we know enough to make one." In Abstracts for the STI & HIV World Congress (Joint Meeting of the 23rd ISSTDR and 20th IUSTI), July 14–17, 2019, Vancouver, Canada. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/sextrans-2019-sti.744.

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Corrêa, Marilza, Maria Leal, Elza Scott, Adenilza Bello, Eduardo Duarte, and Ellen Jessouroun. "Characterization of native and deacylated Lipid A from lipooligosaccharide of Neisseria meningitidis Serogroup B." In III Seminário Anual Científico e Tecnológico de Bio-Manguinhos. Instituto de Tecnologia em Imunobiológicos, 2015. http://dx.doi.org/10.35259/isi.sact.2015_28598.

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Ishii, Kazuyuki, Yohei Iwasaki, Yasuaki Esumi, and Ryohei Yamasaki. "SYNTHESIS OF A TETRASACCHARIDE, A PARTIAL STRUCTURE OF LIPOOLIGOSACCHARIDE (LOS) PRODUCED BY NEISSERIA GONORRHOEAE STRAIN 15253." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.596.

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Yamasaki, Ryohei, Tetsu Maruyama, Uichirou Yabe, Takuji Aoki, and Shunpei Asuka. "SPECIFIC OLIGOSACCHARIDE STRUCTURE EXPRESSED IN LIPOOLIGOSACCHARIDES ARE IMMUNOGENIC IN HUMANS." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.706.

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