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Dissertations / Theses on the topic 'Liposomas'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Tomsen, Melero Judit. "Study of New Liposomes for the Delivery of Enzymes through Biological Membranes." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/673786.

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Els liposomes són nanovesícules lipídiques àmpliament explorades per ser utilitzades com a transportadors d’actius terapèutics per al desenvolupament de noves nanomedicines. En la present Tesi s’ha estudiat l’ús d’aquests sistemes liposomals funcionalitzats amb lligands per ser utilitzats com a nanotransportadors d’enzims, específicament, pel transport eficaç de l’enzim α-galactosidasa a través de les membranes biològiques, com la membrana cel·lular o la barrera hematoencefàlica, per tal d’aconseguir un nou producte farmacèutic pel tractament de la malaltia de Fabry. La malaltia de Fabry és un

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2

Rodríguez, Fernández Silvia. "Phosphatidylserine-rich liposomes to tackle autoimmunity. En route to translationality." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667944.

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Les malalties autoimmunitàries estan causades per defectes en la tolerància immunològica, i afecten a gairebé un 10% de la població. Darrerament, diverses intervencions mèdiques han convertit aquestes malalties en cròniques, però el seu diagnòstic encara comporta morbiditat i mortalitat elevades. Així, un repte biomèdic urgent és el desenvolupament de teràpies que puguin restablir selectivament la tolerància, aturin l’atac autoimmunitari i permetin la regeneració del teixit danyat. En condicions fisiològiques, la fagocitosi de cèl·lules apoptòtiques per part de fagòcits com les cèl·lules dendr

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3

Vázquez, González Martha Leticia. "Desarrollo y caracterización de liposomas para aplicación tópica de fármacos." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/360585.

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La piel es el órgano más extenso y accesible del cuerpo, debido a ello la administración de fármacos por vía tópica para efectos locales o sistémicos ha sido ampliamente documentada. A pesar de todas las ventajas que la administración tópica de fármacos ofrece, la piel y su compleja estructura formada de múltiples capas, la cual le proporciona excelentes propiedades de barrera, hacen que la administración de medicamentos a través de esta vía sea un proceso complicado. En las últimas décadas, con la finalidad de evadir la extraordinaria función de barrera del estrato córneo, se han empleado

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4

Toro, Vergara Claudia Andrea. "Efecto de la adición de 6-O-Miristil sacarosa sobre la bicapa de liposomas de POPC y vesículas de DODAC." Tesis, Universidad de Chile, 2006. http://www.repositorio.uchile.cl/handle/2250/105525.

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Memoria para optar al Título de Químico<br>En la industria de los surfactantes es cada vez mayor el interés en la producción y aplicación de compuestos derivados de fuentes renovables, entre los cuales se pueden destacar los ésteres de sacarosa. Estos surfactantes son compuestos biodegradables de baja toxicidad, no sensibilizantes, no alergénicos, adecuados como emulsificantes, emolientes y humectantes. La utilización de diferentes tipos de surfactantes en la extracción de lípidos o como agentes solubilizantes de membranas lipídicas, involucra también el empleo de liposomas como modelos de mem

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Busquets, i. Viñas Ma Antonia. "Els Liposomes com a model de membrana. Aplicació a l'estudi de les interaccions entre opiàcis i fosfolípids." Doctoral thesis, Universitat de Barcelona, 1985. http://hdl.handle.net/10803/672857.

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Els liposomes o vesícules lipídiques van ésser descrites per primera vegada als anys seixanta per Bangham i Horne (1962), després de l'observació per microscopia electronica d'una suspensió de fosfolípids d'orígen cel·lular aillats i purificats, com una sèrie de bicapes concèntriques de lípid que incloïen un espai aquós. Des del seu descobriment, els liposomes han sigut objecte d'estudi per part d'un gran número de laboratoris degut a la seva versatilitat en tamany, càrrega superficial, composició lipídica i varietat de principis actius que poden encapsular tant en la fase

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6

Bueno, López Dolores. "Peptide functionalized nanoliposomes for biomolecule intracellular delivery, prepared using compressed CO2." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2020. http://hdl.handle.net/10803/670422.

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La malaltia de Fabry és un trastorn d’emmagatzematge lisosòmic (LSD), una malaltia rara causada per una mutació gènica en el cromosoma X, que codifica l’enzim α-galactosidasa A (GLA). La GLA hidrolitza els residus α-D-galactosils terminals de glicosfingolípids neutres. Així, la manca d’aquest enzim provoca l’acumulació d’aquestes molècules, principalment globotriaosilceramida (Gb3), als lisosomes d’algunes cèl·lules. El tractament real es basa en la teràpia de reemplaçament d’enzim (ERT) que consisteix en l’administració intravenosa de l’enzim deficient. Tot i això, l’èxit es limita a causa d’

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7

Babot, Marquillas Clara. "A novel approach for tooth whitening: liposome-encapsulated reductant. In vitro efficacy studies and characterization of the treated teeth including synchrotron techniques." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/671920.

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En aquesta tesi es conceptualitza, desenvolupa i optimitza un tractament blanquejant per a la seva aplicació a la cavitat oral, basat en un enfocament diferent a la oxidació. També s’estudien els seus efectes sobre l’estructura dental. Es va plantejar la hipòtesi que l’agent reductor metabisulfit de sodi (MBS) podia tenir una acció blanquejant sobre les taques de les dents, per saturació dels dobles enllaços conjugats. Com a prova de concepte, les reacció entre l’àcid tànnic (TA) i peròxid de carbamida (CP) o MBS es van monitoritzar durant 48 hores mesurant la seva absorbància, per tal de c

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8

Monroig, Marzá Óscar. "Diseño y optimización de liposomas para un uso como sistema de suministro de nutrientes a larvas de peces marinos." Doctoral thesis, Universitat de València, 2006. http://hdl.handle.net/10803/10348.

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Las deficiencias nutricionales de las presas vivas usadas como primer alimento exógeno en el cultivo de larvas de peces marinos hacen necesaria la suplementación de las dietas con nutrientes que satisfagan los requerimientos de las larvas. Los liposomas constituyen una herramienta con gran potencial ya que pueden formularse con nutrientes hidrosolubles disueltos en su fase acuosa y liposolubles inmersos en el ambiente lipofílico entre las cadenas de ácidos grasos de los fosfolípidos. Este estudio valora el empleo de liposomas para suministrar nutrientes a larvas de peces marinos a través de do

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9

Fuentes, Barahona Pablo César. "Desactivación del O2(a¹Δg) por licopeno y por los ácidos rosmarínico y carnósico en liposomas de dodac y de DPPC". Tesis, Universidad de Chile, 2014. http://repositorio.uchile.cl/handle/2250/145792.

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Memoria para optar al Título Profesional de Químico y al Grado de Magíster en Química, área de especialización en coloides<br>El metabolismo celular es un proceso natural en los organismos vivos que conduce inevitablemente a la producción de especies reactivas del oxígeno, conocidas como ROS, las cuales, son agentes oxidantes altamente reactivos capaces de atacar células, causando en ellas la pérdida de su estructura y funciones. El exceso de ROS en el organismo, un estado que se conoce como “estrés oxidativo”, es mantenido bajo control por mecanismos celulares y especies antioxidantes, e

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10

Heeremans, Anneke. "Liposomes in thrombolytic therapy : t-PA targeting with plasminogen-liposomes, a novel concept = Liposomen voor thrombolytische therapie /." [S.l. : s.n.], 1995. http://www.gbv.de/dms/bs/toc/186694245.pdf.

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11

García, Díaz María. "Drug delivery in photodynamic therapy: From pharmaceutics to animal testing." Doctoral thesis, Universitat Ramon Llull, 2012. http://hdl.handle.net/10803/81987.

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S'ha estudiat el desenvolupament de fotosensibilitzadors i la seva formulació en teràpia fotodinàmica. S'han caracteritzat les propietats fotofísiques dels fotosensibilitzadors porficènics. S'han proposat diferents estratègies tals com la introducció de grups carboxilat en la perifèria o ions de metalls pesants en el nucli, per millorar el disseny de nous fotosensibilitzadors basats en el macrocicle porficènic. Entre ells, el temocè (m-THPPo), el porficè anàleg a la temoporfina, mostra excel•lents propietats fotofísiques, fotoestabilitat i alta eficàcia fotodinàmica. A causa de la seva alta

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12

Bohl, Kullberg Erika. "Tumor Cell Targeting of Stabilized Liposome Conjugates : Experimental studies using boronated DNA-binding agents." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3435.

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13

Laníková, Petra. "Studium vlivu lipozomálních platinových cytostatik na nádorové buňky pomocí voltametrických metod." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-316850.

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Aim of this thesis is voltammetric study influence of liposomal platinum cytostatics on cancer cells. One of the goals is summarize available informations about influence of cisplatine on cancer cells, its encapsulation into liposome and affection of this cytostatic cisplatin encapsulated in liposome on cancer cell lines. In literary recherche is detail description of these issues. Than is there specification of voltammetric methods, which serve to electrochemical detection of cisplatin. Based on literary recherche was chosen the best method for detection and subsequently the method was optima

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Chen, Xiaoyu. "Investigation of liposomes and liposomal gel for prolonging the therapeutic effects of pharmaceutical ingredients." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1524.

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15

RIBEIRO, Lidiane Radoll. "Encapsulação da genisteína em lipossomas: caracterização das interações farmacolipídeo, estabilidade e atividade antioxidante." Universidade Federal de Goiás, 2008. http://repositorio.bc.ufg.br/tede/handle/tde/1029.

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Made available in DSpace on 2014-07-29T15:12:42Z (GMT). No. of bitstreams: 1 Dissertacao Liliane Radoll Ribeiro.pdf: 85648 bytes, checksum: 100baebe5e75ae9143311e745c1f60d3 (MD5) Previous issue date: 2008-04-28<br>Genistein is the most abundant isoflavone, displaying the largest number of biological activities. Most studies on genistein have been based on its antioxidant, estrogenic, tyrosine kinase and carcinogenesis inhibitor activities. Genistein is practically insoluble in water and oil in the active form of aglicone, which presents a technical difficulty. To circumvent this problem, the

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16

Pejaver, Satish K. "Kinetics in liposomal systems : drug stabilization ; synthesis and degradation of liposome prodrugs /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487323583620435.

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17

Fialaire, Anne. "Liposomes d'amphotéricine B : étude pharmacotoxicologique, mise en forme et contrôle d'une suspension liposomale." Paris 5, 1991. http://www.theses.fr/1991PA05P213.

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Nieth, Anita Katharina [Verfasser], and Winfried [Akademischer Betreuer] Römer. "Liposomes as versatile tools: adaptation of bacteriophage therapy against intracellular bacterial pathogens by liposomal vectorization and liposomal analysis of synthetic glycolipids as surface receptors." Freiburg : Universität, 2015. http://d-nb.info/1119327210/34.

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19

Marques, Joana. "Exploration of sulfated polysaccharides as antimalarials and as targeting molecules for nanovector-mediated drug delivery to Plasmodium-infected cells." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/359656.

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Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the protist Plasmodium spp. The clinical, social and economic burden of malaria has led to several waves of serious efforts to reach its control and eventual eradication, without success to this day. With the advent of nanoscience, renewed hopes have appeared of finally obtaining the long sought-after magic bullet against malaria in the form of a nanovector for the targeted delivery of antimalarial dru

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Sánchez, Martín Ma Jesús. "Estudios biofísicos de péptidos sintéticos de la proteína de envoltura E1 del GBV-C/HGV y su relación con el VIH." Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/32123.

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El virus C (GBV-C) o virus de la hepatitis G (HGV) está relacionado con el virus de la hepatitis C (HCV) ya que tiene una organización genómica y una homología en la secuencia muy próxima pero, sin embargo, no parece causar hepatitis ni ningún otro tipo de patología. En los últimos años, se han publicado numerosos trabajos en los que se asocia la co-infección del GBV-C/HGV y el virus de la inmunodeficiencia humana (VIH) con una menor progresión de la enfermedad causada por el virus VIH así como con una mayor supervivencia de los pacientes una vez que el SIDA se ha desarrollado. Basándonos en

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Wild, Thomas Jacob. "Development of self organising size-limited liposomal clusters using asymmetric Janus-textured liposomes and DNA-amphiphiles." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/18331/.

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Current technologies focus on the use of single drug delivery carriers delivering a single drug species, or multiple species, in a compromisingly loaded or damaged state. Here we aim to develop controlled liposome (vesicle) clusters as potential multi-drug carriers for applications in nanomedicine. Specifically; applications include but are not limited to, combinational therapeutics and for the simultaneous delivery of prodrug and complementary activating enzyme. To this end, we are utilising a platform where different liposomes can be connected through DNA linkers, in hope to deliver multiple

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Thibault, Benoit. "Les liposomes : méthodes de préparation." Paris 5, 1990. http://www.theses.fr/1990PA05P177.

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Pujol, Brugués Alba. "Desenvolupament, caracterització i avaluació in vitro-ex vivo de noves formulacions tòpiques pel tractament de la leishmaniosi cutània." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/285971.

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La leishmaniosi constitueix un conjunt de malalties causades per diferents espècies del gènere Leishmania que presenten diferents formes clíniques depenent de l’espècie, del seu tropisme i de la resposta immune de l’hoste. Les manifestacions clíniques inclouen lesions cutànies (leishmaniosi cutània), mucocutànies (leishmaniosi mucocutània) i viscerals (leishmaniosi visceral o Kala-azar). Els fàrmacs actualment disponibles per al tractament de la leishmaniosi en general inclou antimonials pentavalents, amfotericina B, miltefosina i paromomicina entre altres, molts d'ells amb grans limitacions r

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Freva, Patrick. "Apport des liposomes thermo-sensibles dans le ciblage des drogues antimitotiques : études "in vitro" et "in vivo"." Paris 5, 1989. http://www.theses.fr/1989PA05P144.

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25

Nieves, Calatrava Ingrid. "Polyene sphingolipids with latent fluorescence: new tools to study the biophysical properties of cellular membranes." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/347964.

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One of the ultimate goals in biomedicine is to understand the relationship between structure, function, and dynamics of biomolecules in living cells. The biophysical tools designed to gain more insight into metabolism, trafficking and interaction of the sphingolipids (SLs), require the use of high molar concentrations of fluorescence lipid analogues, labelled with bulky chromophores, such BODIPY or NBD, resulting in altered biophysical properties of the cell membrane. Recently, lipids tagged with conjugated linear polyene moieties, which are strongly absorbing chromophores that may attain

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Vasconcelos, Pacheco Aimee. "Diseño y síntesis de nanosistemas derivatizados con péptidos y su aplicación en biomedicina." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/360591.

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La introducción de la nanomedicina en el ámbito de la farmacología ha revolucionado la administración de fármacos, con la aparición de nuevos tratamientos con mayor especificidad, aumentando el rendimiento biológico y farmacológico, ofreciendo así alternativas interesantes para formular nuevas moléculas. El presente trabajo tiene como finalidad el diseño de NPs poliméricas y liposomas para su aplicación en la “Terapia Ocular” y el “Diseño de inhibidores del HIV-1”. En la primera parte de este estudio se desarrollaron formulaciones que contienen Flurbiprofeno, fármaco antiinflamatorio no estero

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Bleher, Stefan [Verfasser], Regine [Akademischer Betreuer] Süss, and Rolf [Akademischer Betreuer] Schubert. "Evaluation of novel lipopolymers to impart stealth-like properties to liposomes = Untersuchung neuer Lipopolymere zur Zirkulationszeitverlängerung von Liposomen." Freiburg : Universität, 2019. http://d-nb.info/1202010792/34.

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Trébaol, Annai͏̈ck. "Etude préléminaire "in vitro" de l'activité antiseptique de la chlorhéxidine sous forme liposomale en vue d'une utilisation en odonto-stomatologie." Paris 5, 1993. http://www.theses.fr/1993PA05P267.

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29

Liu, Xin. "Fliposomes: pH-sensitive liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome mebrane." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/149.

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As a promising pH-triggerable molecular switch, trans -2-aminocyclohexanol (TACH) has a variety of applications. By introducing two hydrocarbon tails, multiple TACH-based lipids (flipids) have been designed and studied that are able to perform a drastic conformational flip upon protonation, loosening the stacking of hydrocarbon tails in lipid bilayers. Liposomes constructed from such flipids (fliposomes) can be disrupted by this acid-triggered conformational flip to cause a rapid release of a cargo specifically in areas of increased acidity (such as inflammation or ischemic tissues, solid tumo

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Chen, Su. "Photothérapie dynamique vectorisée contre le rétinoblastome : conception, Synthèse et Etudes photobiologiques de photosensibilisateurs excitables à deux photons." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS031/document.

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La photothérapie dynamique (PDT) est un nouveau traitement n’induisant potentiellement pas de mutation et utilisable pour lutter contre le rétinoblastome. Les dérivés de porphyrine utilisés comme Ps dans la Thérapie PhotoDynamique (PDT) sont largement étudiés depuis la naissance du premier Ps de synthèse (l’HpD). Une limitation importante de la PDT provient de la faible profondeur (confinée près de la surface) de pénétration de la lumière (λ <700 nm) employée pour l'excitation du Ps. Afin de fournir une énergie d’activation suffisante pour produire l’oxygène singulet dans la fenêtre thérape

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Wessman, Per. "Physico-Chemical Investigations of, and Characterization of Model Membranes for, Lipid-Peptide Interactions." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89432.

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Kachatkou, Dzmitry. "Photophysical and photobiological characteristics of liposomal forms of mTHPC Propriétés photophysiques et photobiologiques des formes liposomales de la mTHPC." Thesis, Nancy 1, 2009. http://www.theses.fr/2009NAN10060/document.

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Pour améliorer les paramètres pharmacologiques d’un photosensibilisateur de seconde génération, la méta-tétra(hydroxyphényl)chlorine (mTHPC), plusieurs formules liposomales commerciales ont été élaborées, parmi elles le Foslip, qui correspond à la mTHPC dans des liposomes conventionnels. L’objectif de ce travail est d’étudier les caractéristiques photophysiques et photobiologiques du Foslip. L’exposition des suspensions de Foslip à de petites doses de lumière (10 mJ) a conduit à une baisse significative de la fluorescence, qui a cependant été restaurée après destruction des liposomes. Nous att

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Ruiz, García Marta. "Design, characterization and optimization of a novel liposomal based food supplement against chronic fatigue syndrome." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671428.

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In today’s society, people’s interest against health care is growing every day. On a health- concerned population, food supplements and nutraceuticals are products with an increasing interest among the global community. This thesis arises as an industrial doctorate project, with the purpose of strengthen the bioavailability and effectivity of the active substances in Reconnect®, a current product commercialized by Vitae Health Innovation, S.L. Coencapsulation of different actives has been widely studied and reported on the last decades, and concretely liposomes have already been used for th

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Celli, Irène. "Liposomes et perspectives thérapeutiques : application à la dermopharmacie." Paris 5, 1992. http://www.theses.fr/1992PA05P200.

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Lim, Howard J. "Role of liposome mediated drug delivery and drug release in determining the therapeutic activity of liposomal formulations of mitoxantrone." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://hdl.handle.net/2429/10000.

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Although liposomal accumulation at the target site is an important issue, the critical parameter defining the activity of a liposomal formulation is drug release, a factor that includes where, when, and how fast the therapeutic agent dissociates from the liposomal carrier. This point was investigated using two liposomal formulations of the anti-cancer drug mitoxantrone. Mitoxantrone was encapsulated via a pH gradient method in liposomes prepared of 1,2 distearoyl-sn-glycero-3-phosphocholine (DSPC)/cholesterol (Choi) (55:45 mol ratio) or 1,2 dimyristoyl-sn-glycero-3-phosphocholine (DMPC)/

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Oussoren, Christien. "Subcutaneous administration of liposomes for lymphatic targeting : a biopharmaceutical study = Subcutane toediening van liposomen voor targeting naar het lymfatische systeem /." [S.l. : s.n.], 1996. http://www.gbv.de/dms/bs/toc/242984827.pdf.

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Loughrey, Helen. "Targeted liposomes." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/29180.

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This thesis presents an optimized and general procedure for coupling proteins to liposomes and investigates certain aspects of the interaction of liposomes with components of the circulation. The object of these studies was to develop straightforward methods for the preparation of well characterized protein-liposome conjugates which exhibit extended circulation half-lives in the blood. These favorable properties should potentiate the use of protein coupled vesicles in in vivo applications such as targeting or diagnostic protocols. A general approach for the preparation of protein-liposome conj

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Mougin-Degraef, Marie Faivre-Chauvet Alain. "Les liposomes." [S.l.] : [s.n.], 2004. http://theses.univ-nantes.fr/thesemed/PHmougin.pdf.

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39

Velínská, Kamila. "Využití nanofluidního směšování pro přípravu liposomálních nosičů značených gadoliniem pro kontrastní zobrazování magnetickou resonancí (MRI)." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2017. http://www.nusl.cz/ntk/nusl-316164.

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This diploma thesis focuses on the preparation of the liposomes, containing lipids with gadolinium, which are used for a contrast magnetic resonance imaging. The liposomes were prepared by the lipid film hydration followed by an extrusion and also by a new nanofluid mixing method on the NanoAssemblr Benchtop. The preparation technology has been optimized for parameters such as the composition of lipids, the flow rate ratio and total flow rate. The method of modification of the liposomes surface by gadolinium complexes has been developed. This method is using a conjugation reaction between the

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Foulquier, Christine. "La vaccination par voie orale." Paris 5, 1996. http://www.theses.fr/1996PA05P179.

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Garnier, Boris. "Développement de vecteurs liposomaux fonctionnalisés par des protéines dérivées de l’Annexine 5 et encapsulant des marqueurs pour l’imagerie." Thesis, Bordeaux 2, 2009. http://www.theses.fr/2009BOR21651/document.

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Ce sujet se situe dans le cadre de la mise au point de systèmes de délivrance de composés thérapeutiques ou d’imagerie, c’est à dire d’objets qui doivent transporter des composés dans un organisme et posséder une spécificité pour une zone à traiter ou à imager. Les objectifs de mon travail de thèse étaient l’addition d’une spécificité aux liposomes grâce à la liaison ou l’utilisation de protéines dérivées de l’Annexine 5 (Anx5) et l’encapsulation dans l’espace interne des vésicules de composés permettant le suivi de ces vecteurs. Nous avons tout d’abord mis au point des liposomes pour lesquels

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Moles, Meler Ernest. "Development of polyvalent erythrocyte- and parasitized erythrocyte-targeted nanovectors as novel site-specific drug delivery approaches for Plasmodium falciparum malaria chemotherapy." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/360333.

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Bearing in mind the absence of an effective preventive vaccine against malaria (WHO, 2015) and its severe clinical manifestations that are principally associated with red blood cell (RBC) destruction and parasitized-RBC (pRBC) cytoadherence to host cells causing in turn nearly half a million deaths every year, this disease represents nowadays a major threat to life and consequently its control and ultimate global eradication must be undertaken without preconceptions. Additionally, the basic rationale followed by most of the currently marketed antimalarial approaches is based on the administ

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Gyanani, Vijay. "Turning stealth liposomes into cationic liposomes for anticancer drug delivery." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/147.

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Targeting the anticancer agents selectively to cancer cells is desirable to improve the efficacy and to reduce the side effects of anticancer therapy. Previously reported passive tumor targeting by PEGylated liposomes (stealth liposomes) have resulted in their higher tumor accumulation. However their interaction with cancer cells has been minimal due to the steric hindrance of the PEG coating. This dissertation reports two approaches to enhance the interaction of stealth liposomes with cancer cells. First, we designed a lipid-hydrazone-PEG conjugate that removes the PEG coating at acidic pH as

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Sandström, Maria. "Physico-Chemical Investigations of Bilayer Discs and Related Lipid Structures Formed in Liposomal Systems Intended for Triggered Release." Doctoral thesis, Uppsala University, Department of Physical Chemistry, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7606.

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<p>This thesis describes results from fundamental studies of liposomes intended for drug delivery and pH or temperature triggered release. In addition, the effect of lipid composition on bilayer disc formation and a potential application of the bilayer discs were investigated.</p><p>The lower pH encountered by endocytosed liposomes can be utilized to trigger drug release. The mechanisms behind cytosolic drug delivery were investigated using two different kinds of pH-sensitive liposomes. The results indicate that incorporation of non-lamellar forming lipids into the endosome membrane may allow

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Merlin, Jean-Louis. "Liposomes thermosensibles d'adriamycine : mise au point, validation in vitro : effet sur la multidrug resistance." Nancy 1, 1992. http://www.theses.fr/1992NAN10423.

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Freund, Olivier. "Applications à la thérapie génique et au transport de médicaments d'un nouveau vecteur lipidique multilamellaire." Bordeaux 2, 1998. http://www.theses.fr/1998BOR28596.

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Foing, Muriel. "Les méthodes d'étude des liposomes en cosmétologie." Paris 5, 1992. http://www.theses.fr/1992PA05P016.

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Dufour-Delachaux, Sylvie. "De la nouvelle génération des formes cosmétiques ou le défi de la dermocosmétologie moderne." Paris 5, 1991. http://www.theses.fr/1991PA05P020.

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Lejoyeux, Pierre. "Interaction d'une série alkyloxazolopyridocarbazole avec des liposomes : étude thermodynamique et cinétique." Paris 5, 1989. http://www.theses.fr/1989PA05P009.

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Saverot-Dauvergne, Agnès. "Modifications des lipoprotèines de haute densité (HDL) d'origine humaine et de leurs sous-classes (HDL2, HDL3) par des liposomes de phosphatidylcholines et de sphingomyélines : analyse biochimique et étude structurale par résonance paramagnétique électronique (RPE)." Paris 5, 1990. http://www.theses.fr/1990PA05P619.

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