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Journal articles on the topic 'Liposomas'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Ortega-Galindo, Ana Saret, Lucero Díaz-Peralta, Arturo Galván-Hernández, Iván Ortega-Blake, Alejandro Pérez-Riascos, and Yareli Rojas-Aguirre. "Los liposomas en nanomedicina: del concepto a sus aplicaciones clínicas y tendencias actuales en investigación." Mundo Nano. Revista Interdisciplinaria en Nanociencias y Nanotecnología 16, no. 31 (2023): 1e—26e. http://dx.doi.org/10.22201/ceiich.24485691e.2023.31.69795.

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Los liposomas son vesículas artificiales biocompatibles y biodegradables que poseen una estructura con dos compartimentos capaces de albergar moléculas hidrofílicas y lipofílicas, respectivamente. Los liposomas han sido ampliamente investigados durante los últimos veinte años como sistemas de liberación de fármacos, lo cual ha resultado en el desarrollo de diversas tecnologías como liposomas Stealth® y DepoFoam®. Asimismo, han surgido liposomas funcionalizados en su superficie con biomacromoléculas que pueden reconocer blancos biológicos específicos, dando lugar a potenciales terapias de alta

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2

Solera, F., J. Vega, S. Madrigal, and A. Loria. "Estudio sobre las interacciones de interfase entre vesículas biológicas y superficies inorgánicas de biomateriales por medio de microscopía de fuerza atómica." Revista Científica 22, no. 1 (2012): 73–80. http://dx.doi.org/10.54495/rev.cientifica.v22i1.125.

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Incompatibilidades de interfase en la interacción entre las micropartículas biológicas que normalmente circulan en la sangre y la superficie de los implantes de biomateriales están normalmente asociadas con posteriores reacciones de rechazo por parte del sistema inmune. Ello requiere un modelo explicativo de la conducta observada en la interface de los liposomas y las plaquetas en contacto con biomateriales y superficies inorgánicas. Por lo tanto, el análisis de la relación entre el equilibrio iónico de las fuerzas de superficie de atracción entre liposoma -superficie /grado de deformación y e

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Toro, Azahara I., and María José De Jesús Valle. "Cesión de fármacos desde liposomas en distintos medios biorrelevantes." FarmaJournal 6, no. 1 (2021): 75–84. http://dx.doi.org/10.14201/fj2021617584.

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Los liposomas constituyen sistemas vesiculares ideales para la liberación controlada y vectorización de fármacos a través de su administración pulmonar, debido a su similitud con las membranas celulares y su gran versatilidad. El citrato de sildenafilo, representa un óptimo modelo de fármaco para ser incorporado en estas vesículas lipídicas para el tratamiento de la hipertensión pulmonar. El objetivo del trabajo fue caracterizar el comportamiento de los liposomas cargados con sildenafilo y evaluar la cesión del fármaco en distintos medios biorrelevantes. Se elaboraron liposom

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4

Moreno, Yuri Lorena, Nathalie Becerra, Sandra Patricia Chaparro, and Julia Reyes Cuellar. "Evaluación de la sensibilidad colorimétrica para la determinación de nanoestructuras compuestas de polidiacétileno/lípidos, usando espectroscopia de absorción electrónica y UV-Vis fluorescencia." Acta Agronómica 65, no. 3 (2016): 268–75. http://dx.doi.org/10.15446/acag.v65n3.45689.

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El desarrollo de sensores basados en nanoestructuras de polidiacétileno (PDA) se atribuye a sus propiedades cromáticas, actuando como transductor colorimétrico. Este material único permite un acercamiento de primer nivel de investigadores de ciencias básicas y aplicadas e ingeniería de biomiméticos cromáticos en el país, hacia la síntesis, características y propiedades de bloques nanométricos denominados liposomas para la construcción de sensores basados en polidiacétileno. En el presente estudio, se evaluó el periodo de fotopolimerización y el efecto de estímulos como temperatura, pH, interac

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5

Al Badri, Yaqeen Nadheer, Cheng Shu Chaw, and Amal Ali Elkordy. "Insights into Asymmetric Liposomes as a Potential Intervention for Drug Delivery Including Pulmonary Nanotherapeutics." Pharmaceutics 15, no. 1 (2023): 294. http://dx.doi.org/10.3390/pharmaceutics15010294.

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Liposome-based drug delivery systems are nanosized spherical lipid bilayer carriers that can encapsulate a broad range of small drug molecules (hydrophilic and hydrophobic drugs) and large drug molecules (peptides, proteins, and nucleic acids). They have unique characteristics, such as a self-assembling bilayer vesicular structure. There are several FDA-approved liposomal-based medicines for treatment of cancer, bacterial, and viral infections. Most of the FDA-approved liposomal-based therapies are in the form of conventional “symmetric” liposomes and they are administered mainly by injection.

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Gavilanes Quizhpi, Petronio, Vladimir Alexander Aguirre Yela, Pedro Rachid Romero Saker, and Vicente Apolonio Delgado Rodriguez. "Determinación de la acción del azufre nanoencapsulado en liposomas aplicado al cultivo in vitro del hongo Botrytis fabae." Ciencia 21, no. 3 (2019): 69. http://dx.doi.org/10.24133/ciencia.v21i3.1528.

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Este trabajo de investigación inició de la pregunta de si se produce inhibición en el crecimiento del hongo patógeno Botrytis fabae con el uso de liposomas y nanopartículas de azufre. El objetivo fue explicar cómo utilizando concentraciones 0,001 M de nanopartículas de azufre encapsulado en liposomas de fosfatidilcolina en mezclas de limoneno y octanol, actúan sobre el cultivo in vitro del hongo Botrytis fabae. Durante esta investigación se obtuvieron nanopartículas de azufre. Se demostró que la fosfatidilcolina abarcaba azufre y forma liposomas. Así mismo se identificó el hongo Botrytis fabae

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7

Chavarría Rojas, Marianela, Nathalie Vega-Sánchez, María Fernanda Montero-Jara, Rebeca Marín-Fajardo, and Marianela Chavarría-Rojas. "Liposomas en el desarrollo de formas farmacéuticas semisólidas." Ars Pharmaceutica (Internet) 63, no. 4 (2022): 372–86. http://dx.doi.org/10.30827/ars.v63i4.26059.

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Introducción: los liposomas son nanovesículas esféricas compuestas por fosfolípidos, característica directamente relacionada con su permeabilidad. Son estructuras ampliamente utilizadas como sistemas de entrega de fármacos cuando se administran por vía dérmica y transdérmica. Método: se realizó una revisión bibliográfica considerando artículos científicos y patentes publicados en las siguientes bases de datos: Google Académico, Google Patents, Pubmed, Elsevier, ScienceDirect, Scielo. Se incluyeron artículos en idioma inglés y español publicados de 2012 a 2022, seleccionando los más relev

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Lago, L. A., A. P. Marques Junior, M. M. Melo, E. P. Lago, N. J. F. Oliveira, and F. Alzamora Filho. "Perfil bioquímico sorológico de bovinos inoculados experimentalmente com veneno crotálico iodado livre e iodado incorporado em liposomas." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 56, no. 5 (2004): 653–57. http://dx.doi.org/10.1590/s0102-09352004000500013.

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Investigou-se o perfil sorológico de bovinos inoculados com veneno crotálico detoxificado pelo método de iodação e iodação com encapsulação em liposomas. Onze fêmeas com idade média de 18 meses e peso médio de160kg, foram inoculadas com 0,03mg/kg de peso vivo do veneno crotálico do tipo crotamina positivo. Cinco animais receberam o veneno iodado livre, cinco o iodado encapsulado em liposomas e um animal recebeu o mesmo veneno na forma natural, para controle da letalidade da amostra de veneno utilizada. Não houve alterações significativas na concentração de proteínas totais, uréia e creatinina

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Padrón-Vázquez, Verónica, Vicente Gónzalez-Rodríguez, Ana Isabel Mireles-Arriaga, Jorge Emmanuel Mejía-Benavides, and Erik Díaz-Cervantes. "Nanomateriales transportadores de capsinoides como alternativa para inhibir Fusarium oxysporum." Investigación y Desarrollo en Ciencia y Tecnología de Alimentos 8, no. 1 (2023): 926–32. http://dx.doi.org/10.29105/idcyta.v8i1.119.

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El objetivo del presente trabajo es determinar el uso de nanopartículas de dióxido de silicio y liposomas de lecitina de soya, transportadoras de una familia de Capsinoides, en la inhibición de Fusarium oxysporum. Considerando que dicho hongo comúnmente ataca a S. lycopersicum (jitomate). Lo anterior a partir de métodos basados en química computacional, específicamente Docking molecular. Los resultados muestran que el mejor vehículo es la fosfatidilcolina (componente principal de los liposomas de lecitina de soya) transportando la dihidrocapsaicina.

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10

Barbero, Jimena, Amparo Sánchez Navarro, and María José De Jesús-Valle. "Liposomas de ergosterol en formulaciones liofilizadas de administración bucal." FarmaJournal 9, no. 2 (2024): 7–17. http://dx.doi.org/10.14201/fj202492717.

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Los liposomas son vesículas lipídicas utilizadas como vehículos de fármacos que se estabilizan mediante liofilización. La vía bucal permite conseguir efectos sistémicos o locales. El ergosterol es el principal esterol de la membrana plasmática de los hongos y presenta diversas propiedades. El objetivo de este trabajo es obtener formulaciones mucoadhesivas bucales a partir de liposomas de fosfatidilcolina y ergosterol preparados por sonicación y estabilizados por liofilización utilizando diferentes excipientes. Se prepararon liofilizados con dos geometrías y se caracterizaron las formulaciones

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Kumar, Amit, Madhu Gupta, and Simran Braya. "Liposome Characterization, Applications and Regulatory landscape in US." International Journal of Drug Regulatory Affairs 9, no. 2 (2021): 81–89. http://dx.doi.org/10.22270/ijdra.v9i2.474.

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Liposomes are lipid based drug carrier whose therapeutic performance depends on their structure. Liposomes offer several advantages over the conventional drug like target drug delivery, reduced toxicity, and extended pharmacokinetics. Characterization and Identification of critical attribute of liposomal formulation and suitable strategies for control during product development is important for quality of the liposomal drug product. This paper discusses the current status of the liposomal drug product and strategy used in regulating liposome product. Despite of lack of regulatory guidelines ma

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Rodriguez, Yanina I., Ana Laura Canil, Paola Carvalho, et al. "Guía para la implementación de la disposición ANMAT nº 9943/19: Especialidades medicinales nanofarmacéuticas, doxorrubicina liposomal." Revista Científica ANMAT 1 (November 29, 2020): e11. http://dx.doi.org/10.62035/rca.1.11.

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El uso de liposomas como sistemas de administración de fármacos ha visto un gran desarrollo en las últimas décadas. En el caso particular de la doxorrubicina, su encapsulación dentro de estas vesículas lipídicas permite reducir sus efectos tóxicos manteniendo su eficacia terapéutica. Debido a su complejidad, cambios en el método de elaboración, en la composición o en la calidad de la materia prima del producto pueden conducir a variaciones considerables en las propiedades fisicoquímicas y en la eficacia de la formulación liposomal. Por lo tanto, la caracterización de estos productos requiere d

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13

Al Mutairi, Amal Abdullah, and Mohsen Mahmoud Mady. "Biophysical Characterization of (DOX-NPtm): FTIR and DSC Studies." JOURNAL OF ADVANCES IN PHYSICS 20 (March 3, 2022): 41–47. http://dx.doi.org/10.24297/jap.v20i.9194.

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Doxorubicin loaded into liposomes grafted with polyethylene glycol (PEG) has been demonstrated to have a longer circulation time and lower cardiotoxicity than doxorubicin (DOX). This study aims to investigate the biophysical characterization of a marketed formulation DOX-encapsulated liposome (DOX-NPTM). The interactions between doxorubicin and liposomal lipids can help in liposomal development. The liposome and DOX-NPTM were characterized in terms of differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The rheological properties of liposomal samples were

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Calderón García, Blanca, and María José De Jesús Valle. "Liofilización de liposomas para su administración pulmonar." FarmaJournal 7, no. 2 (2022): 7–17. http://dx.doi.org/10.14201/fj202272717.

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El citrato de sildenafilo se ha convertido, en los últimos años, en un agente terapéutico oral utilizado para el tratamiento de la hipertensión arterial. Debido a que presenta ciertas limitaciones, como una reducción significativa de la biodisponibilidad oral y de la actividad farmacológica debido al metabolismo hepático de primer paso, se han propuesto formulaciones innovadoras para su administración por vía pulmonar, permitiendo minimizar los efectos adversos sistémicos y el efecto de primer paso. El objetivo del trabajo es elaborar liposomas cargados de sildenafilo y posteriormente li

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Goins, Beth A., and William T. Phillips. "The Use of Scintigraphic Imaging During Liposome Drug Development." Journal of Pharmacy Practice 14, no. 5 (2001): 397–406. http://dx.doi.org/10.1106/da2m-fyju-1xxq-ppkk.

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Liposomes, spherical lipid bilayers enclosing an aqueous space, have become an important class of drug carriers. This review describes the usefulness of scintigraphic imaging during the development of liposome-based drugs. This imaging modality is particularly helpful for tracking the distribution of liposomes in the body, monitoring the therapeutic responses following administration of liposome-based drugs, and investigating the physiological responses associated with liposome administration. Scintigraphy also can be used to monitor the therapeutic responses of patients given approved liposom

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Cattel, Luigi, Maurizio Ceruti, and Franco Dosio. "From Conventional to Stealth Liposomes a new Frontier in Cancer Chemotherapy." Tumori Journal 89, no. 3 (2003): 237–49. http://dx.doi.org/10.1177/030089160308900302.

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Many attempts have been made to achieve good selectivity to targeted tumor cells by preparing specialized carrier agents that are therapeutically profitable for anticancer therapy. Among these, liposomes are the most studied colloidal particles thus far applied in medicine and in particular in antitumor therapy. Although they were first described in the 1960s, only at the beginning of 1990s did the first therapeutic liposomes appear on the market. The first-generation liposomes (conventional liposomes) comprised a liposome-containing amphotericin B, Ambisome (Nexstar, Boulder, CO, USA), used a

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Umbarkar, Mahesh, Swapnil Thakare, Tanaji Surushe, Amol Giri, and Vaibhav Chopade. "Formulation and Evaluation of Liposome by Thin Film Hydration Method." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 72–76. http://dx.doi.org/10.22270/jddt.v11i1.4677.

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Liposomes are the most advance formulation for targeting and controlled drug delivery system. These liposomes are generally administered by intra-venous route. In this work the liposome was prepared by using thin film hydration method. The formulated liposome is evaluated or characterised by using zeta sizer, Encapsulation efficiency, Entrapment efficiency, In vitro drug release. Main things are drug which are used for formulation of liposome was Diclofenac sodium, it having anti-inflammatory and anti-pyretic effect. The Diclofenac sodium having several adverse effects, such as depression of r

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D’arcy, Yvonne. "Liposomas: una nueva manera de administrar analgésicos." Nursing (Ed. española) 24, no. 7 (2006): 46–47. http://dx.doi.org/10.1016/s0212-5382(06)71139-6.

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Ishida, Tatsuhiro, Hideyoshi Harashima, and Hiroshi Kiwada. "Liposome Clearance." Bioscience Reports 22, no. 2 (2002): 197–224. http://dx.doi.org/10.1023/a:1020134521778.

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The clearance rate of liposomal drugs from the circulation is determined by the rate and extent of both drug release and uptake of liposomes by cells of the mononuclear phagocyte system (MPS). Intravenously injected liposomes initially come into contact with serum proteins. The interaction of liposomes with serum proteins is thought to play a critical role in the liposome clearance. Therefore, in this review, we focus on the role of serum proteins, so-called opsonins, that enhance the clearance of liposomes, when bound to liposomes. In addition to opsonin-dependent liposome clearance, opsonin-

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López-Carvajal, Jhon Esteban, Juan Pablo Bedoya Agudelo, Leonardo Padilla Sanabria, and Jhon Carlos Castaño-Osorio. "Difusión in vitro de liposomas cargados con curcumina y aceite esencial de Lippia origanoides, en una celda de Franz." Revista Productos Naturales 5, no. 2 (2022): 94–95. http://dx.doi.org/10.3407/rpn.v5i2.6819.

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Las celdas de Franz son un instrumento utilizado para evaluar la difusión dérmica y determinar la cinética de liberación de moléculas biológicamente activas como los liposomas, los cuales son vesículas compuestas de fosfolípidos, que han sido empleadas como sistemas de liberación de fármacos.

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Abbase, Eman R., Medhat W. Shafaa, and Mohsen M. Mady. "Competition Between Heparin and Polyethylene Glycol as Biofunctionalization for Improving Stability of Liposomal Doxorubicin." Advanced Science, Engineering and Medicine 12, no. 2 (2020): 271–77. http://dx.doi.org/10.1166/asem.2020.2496.

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In order to improve liposomal doxorubicin stability, differentiation between Heparin and Polyethylene Glycol (PEG) as biofunctionalization for liposomal doxorubicin has been investigated by measuring the entrapment efficiency, size distribution, zeta potential, evaluating the in vitro potential cytotoxicity against MCF-7 (Breast cancer cell) and stability in serum by measuring the drug release rate. We synthesized Four liposomal formulations: (A) Conventional liposomes; DPPC:DOX, (B) Positively charged PEGylated liposomes; DPPC:CHOL:SA:PEG:DOX (C) Negatively charged PEGylated liposomes: DPPC:C

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Heneweer, Carola, Tuula Peñate Medina, Robert Tower, et al. "Acid-Sphingomyelinase Triggered Fluorescently Labeled Sphingomyelin Containing Liposomes in Tumor Diagnosis after Radiation-Induced Stress." International Journal of Molecular Sciences 22, no. 8 (2021): 3864. http://dx.doi.org/10.3390/ijms22083864.

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In liposomal delivery, a big question is how to release the loaded material into the correct place. Here, we will test the targeting and release abilities of our sphingomyelin-consisting liposome. A change in release parameters can be observed when sphingomyelin-containing liposome is treated with sphingomyelinase enzyme. Sphingomyelinase is known to be endogenously released from the different cells in stress situations. We assume the effective enzyme treatment will weaken the liposome making it also leakier. To test the release abilities of the SM-liposome, we developed several fluorescence-b

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Yanagihara, Shin, Yukiya Kitayama, Eiji Yuba, and Atsushi Harada. "Preparing Size-Controlled Liposomes Modified with Polysaccharide Derivatives for pH-Responsive Drug Delivery Applications." Life 13, no. 11 (2023): 2158. http://dx.doi.org/10.3390/life13112158.

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The liposome particle size is an important parameter because it strongly affects content release from liposomes as a result of different bilayer curvatures and lipid packing. Earlier, we developed pH-responsive polysaccharide-derivative-modified liposomes that induced content release from the liposomes under weakly acidic conditions. However, the liposome used in previous studies size was adjusted to 100–200 nm. The liposome size effects on their pH-responsive properties were unclear. For this study, we controlled the polysaccharide-derivative-modified liposome size by extrusion through polyca

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Deol, P., G. K. Khuller, and K. Joshi. "Therapeutic efficacies of isoniazid and rifampin encapsulated in lung-specific stealth liposomes against Mycobacterium tuberculosis infection induced in mice." Antimicrobial Agents and Chemotherapy 41, no. 6 (1997): 1211–14. http://dx.doi.org/10.1128/aac.41.6.1211.

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One recent promising development in the modification of drug formulations to improve chemotherapy is the use of a liposome-mediated drug delivery system. The efficacies of isoniazid and rifampin encapsulated in lung-specific stealth liposomes were evaluated by injecting liposomal drugs and free drugs into tuberculous mice twice a week for 6 weeks. Liposome-encapsulated drugs at and below therapeutic concentrations were more effective than free drugs against tuberculosis, as evaluated on the basis of CFUs detected, organomegaly, and histopathology. Furthermore, liposomal drugs had marginal hepa

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Marqués-Gallego, Patricia, and Anton I. P. M. de Kroon. "Ligation Strategies for Targeting Liposomal Nanocarriers." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/129458.

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Liposomes have been exploited for pharmaceutical purposes, including diagnostic imaging and drug and gene delivery. The versatility of liposomes as drug carriers has been demonstrated by a variety of clinically approved formulations. Since liposomes were first reported, research of liposomal formulations has progressed to produce improved delivery systems. One example of this progress is stealth liposomes, so called because they are equipped with a PEGylated coating of the liposome bilayer, leading to prolonged blood circulation and improved biodistribution of the liposomal carrier. A growing

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Jian, Cheng-Bang, Xu-En Yu, Hua-De Gao та ін. "Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α". Nanomaterials 12, № 1 (2022): 163. http://dx.doi.org/10.3390/nano12010163.

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Prolyl hydroxylase domain-containing protein 2 (PHD2) inhibition, which stabilizes hypoxia-inducible factor (HIF)-1α and thus triggers adaptation responses to hypoxia in cells, has become an important therapeutic target. Despite the proven high potency, small-molecule PHD2 inhibitors such as IOX2 may require a nanoformulation for favorable biodistribution to reduce off-target toxicity. A liposome formulation for improving the pharmacokinetics of an encapsulated drug while allowing a targeted delivery is a viable option. This study aimed to develop an efficient loading method that can encapsula

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Medina, Oula Peñate, Tuula Peñate Medina, Jana Humbert, et al. "Using Alendronic Acid Coupled Fluorescently Labelled SM Liposomes as a Vehicle for Bone Targeting." Current Pharmaceutical Design 26, no. 46 (2020): 6021–27. http://dx.doi.org/10.2174/1381612826666200614175905.

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Background: We recently developed a liposomal nanoparticle system that can be used for drug delivery and simultaneously be monitored by optical or photoacoustic imaging devices. Here we tested the efficacy of alendronate as a homing molecule in SM-liposomes for bone targeting. Methods: Alendronate was immobilized covalently on the liposomal surface and the fluorescent dye indocyanine green was used as a payload in the liposomes. The indocyanine green delivery was analyzed by 3D optical tomography, optical fluorescence scanner, photoacoustic imaging, and by ex-vivo biodistribution studies. Resu

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Chavoshian, Omid, Mahdieh Arabsalmani, Mahmoud Reza Jaafari, et al. "A Phospholipase-A Activity in Soluble Leishmania Antigens Causes Instability of Liposomes." Current Drug Delivery 17, no. 9 (2020): 806–14. http://dx.doi.org/10.2174/1567201817666200731164002.

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Aim: This study aimed to investigate the existence of phospholipase-A (PLA) activity in Soluble L. major Antigens (SLA) because of no reports for it so far. Liposomes were used as sensors to evaluate PLA activity. Objective: Liposomal SLA consisting of Egg Phosphatidylcholine (EPC) or Sphingomyelin (SM) were prepared by two different methods in different pH or temperatures and characterized by Dynamic Light Scattering (DLS) and Thin Layer Chromatography (TLC). Methods: Lipid hydrolysis led to the disruption of EPC liposomal SLA in both methods but the Film Method (FM) produced more stable lipo

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Reyes-Cuellar, Julia Constanza. "Immobilization of recognition elements on a self-assembled monolayers bio-platform." DYNA 84, no. 202 (2017): 263–69. http://dx.doi.org/10.15446/dyna.v84n202.63963.

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Los materiales funcionalizados por adsorción sobre capas autoensambladas de 3-aminopropiltrietoxisilano (APTS) en vidrio (vidrio amino-funcionalizado) sirven para inmovilizar biomoléculas en estructuras usadas para biosensores. Liposomas de polidiacetileno (lip-PDA-NHS) y Biotin PEGilado con NHS se inmovilizaron aprovechando el éster de succinimidilo; y sirvieron para reconocer Tirosinasa o streptavidina (SAV). Debido a la interacción liposoma-PDA-Ty, ocurrió un cambio en la planaridad de la cadena polimérica PDA, percibido como una transición de azul-a-rojo; mientras que, la biotina inmoviliz

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Penabaka, Venugopalaiah, Chandrika Jorepalli, Harika Kandala, et al. "Fabrication and characterization of hydroquinone in liposomal gel for transdermal drug delivery." Future Journal of Pharmaceuticals and Health Sciences 4, no. 3 (2024): 29–36. http://dx.doi.org/10.26452/fjphs.v4i3.628.

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This study aimed to formulate a gel for hydroquinone dermal therapy using liposomes to maintain the active agents' concentration in the skin's deepest layers. Cholesterol was incorporated to enhance the liposome's bilayer characteristics, increasing microviscosity, membrane stability, and blister rigidity. Various methods for liposome preparation exist, but the film hydration method, being the most common, was utilized here. Results for formulation HL6, which had lower levels of Lecithin Cholesterol and rotation speed, revealed a vesicle size of 180.4 nm, a Zeta potential of -37.5 mV, and an e

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Penabaka, Venugopalaiah. "Fabrication and characterization of hydroquinone in liposomal gel for transdermal drug delivery." Fabrication and characterization of hydroquinone in liposomal gel for transdermal drug delivery 4, no. 3 (2024): 29–36. https://doi.org/10.26452/fjphs.v4i3.628.

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This study aimed to formulate a gel for hydroquinone dermal therapy using liposomes to maintain the active agents' concentration in the skin's deepest layers. Cholesterol was incorporated to enhance the liposome's bilayer characteristics, increasing microviscosity, membrane stability, and blister rigidity. Various methods for liposome preparation exist, but the film hydration method, being the most common, was utilized here. Results for formulation HL6, which had lower levels of Lecithin Cholesterol and rotation speed, revealed a vesicle size of 180.4 nm, a Zeta potential of -37.5 mV, and an e

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Maiti, Kuntal, Subhas Bhowmick, Pankaj Jain, Murlidhar Zope, Keyur Doshi, and Thennati Rajamannar. "Comparison of Physicochemical Properties of Generic Doxorubicin HCl Liposome Injection with the Reference Listed Drug." Anti-Cancer Agents in Medicinal Chemistry 18, no. 4 (2018): 597–609. http://dx.doi.org/10.2174/1871520617666171121124610.

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Background: Liposomal doxorubicin is widely used for treating ovarian cancer and Kaposi’s sarcoma. Encapsulation of doxorubicin in highly complex polyethylene glycol–coated (stealth) liposomes prolongs residence time and avoids the systemic toxicity associated with administration of the free drug. Small variations in physicochemical properties introduced during manufacture of liposomes can influence the payload of encapsulated drug, stability of liposomes under physiological conditions, and release of drug at the target tissue. Accordingly, the US Food and Drug Administration and the European

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Agrawal, Surendra S., Vrinda Baliga, and Vaishali Y. Londhe. "Liposomal Formulations: A Recent Update." Pharmaceutics 17, no. 1 (2024): 36. https://doi.org/10.3390/pharmaceutics17010036.

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Liposome-based drug delivery technologies have showed potential in enhancing medication safety and efficacy. Innovative drug loading and release mechanisms highlighted in this review of next-generation liposomal formulations. Due to poor drug release kinetics and loading capacity, conventional liposomes have limited clinical use. Scientists have developed new liposomal carrier medication release control and encapsulation methods to address these limits. Drug encapsulation can be optimized by creating lipid compositions that match a drug’s charge and hydrophobicity. By selecting lipids and addi

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Skupin-Mrugalska, Paulina, Philipp A. Elvang, and Martin Brandl. "Application of Asymmetrical Flow Field-Flow Fractionation for Characterizing the Size and Drug Release Kinetics of Theranostic Lipid Nanovesicles." International Journal of Molecular Sciences 22, no. 19 (2021): 10456. http://dx.doi.org/10.3390/ijms221910456.

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Liposome size and in vitro release of the active substance belong to critical quality attributes of liposomal carriers. Here, we apply asymmetric flow field-flow fractionation (AF4) to characterize theranostic liposomes prepared by thin lipid film hydration/extrusion or microfluidics. The vesicles’ size was derived from multi-angle laser light scattering following fractionation (AF4) and compared to sizes derived from dynamic light scattering measurements. Additionally, we adapted a previously developed AF4 method to study zinc phthalocyanine (ZnPc) release/transfer from theranostic liposomes.

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Akbari, Aezam, Azadeh Ghaffari, Fahimeh Haji-Ahmadi, et al. "Nanobody-functionalized liposomal doxorubicin: A novel strategy for angiogenesis suppression via VEGFR2 targeting." BioImpacts 15 (April 6, 2025): 30707. https://doi.org/10.34172/bi.30707.

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Introduction: Doxorubicin (DOX ) is a widely used first-line treatment for various cancers but causes toxicity. Targeted drug delivery systems, particularly DOX-encapsulated liposomes, show clinical success and lower toxicity. The abnormal angiogenesis in high-grade tumors, making it crucial to develop strategies that target this process in conjunction with chemotherapy. This study presents an innovative formulation of anti-VEGFR2-functionalized liposomal DOX, designed to reduce systemic drug release, enhance drug release and bioavailability at tumor sites, and reducing adverse effects, repres

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Mursheda*1, Ajith Chandran2 Anagha S. Raj3 Jasnath. P. "Perspectives On Liposomes: Recent Developments, Clinical Uses, And Prospects." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1073–84. https://doi.org/10.5281/zenodo.12739742.

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Liposomes are widely recognized as a significant nanoscale drug delivery method with appealing characteristics, including an easy-to-prepare bilayer structure that assembles the cellular membrane and high biocompatibility. Over the past few decades, a great deal of work has gone into developing liposome-based drug delivery systems. Numerous drug candidates have been investigated for their potential to reduce toxicity and prolong the duration of therapeutic effect by encapsulating them in liposomes. A growing number of liposomal-based therapeutics, with a variety of uses in antiviral, anticance

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Nijen Twilhaar, Maarten K., Lucas Czentner, Joanna Grabowska, et al. "Optimization of Liposomes for Antigen Targeting to Splenic CD169+ Macrophages." Pharmaceutics 12, no. 12 (2020): 1138. http://dx.doi.org/10.3390/pharmaceutics12121138.

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Despite promising progress in cancer vaccination, therapeutic effectiveness is often insufficient. Cancer vaccine effectiveness could be enhanced by targeting vaccine antigens to antigen-presenting cells, thereby increasing T-cell activation. CD169-expressing splenic macrophages efficiently capture particulate antigens from the blood and transfer these antigens to dendritic cells for the activation of CD8+ T cells. In this study, we incorporated a physiological ligand for CD169, the ganglioside GM3, into liposomes to enhance liposome uptake by CD169+ macrophages. We assessed how variation in t

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Ramírez Jiménez, Ana R., Adrián Ruiz Olvera, Virginia Melo Ruiz, and Maritza García. "Alternativa con gel de Papaver somniferum (amapola) y Cannabis sativa (marihuana), como tratamiento de artritis reumatoide." Revista de Enfermería Neurológica 10, no. 1 (2011): 16–20. http://dx.doi.org/10.37976/enfermeria.v10i1.123.

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En la elaboración del presente producto farmacéutico (una formulación galénica entre el gel y la emulsión fluida), se utilizaron dos principios activos naturales considerados psicotrópicos o narcóticos: extracto alcohólico de amapola (Papaver somni-ferum) y extracto alcohólico de marihuana (Cannabis sativa); éstos tienen actividad biológica conocida dentro del organismo. Son excelentes analgésicos para pacientes con cáncer terminal pero también tienen propiedades antieméticas, estimulantes del apetito, relajantes oculares, bronquíticos, ansiolíticos. Se conoce que para tener una liberación pro

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Shachi, Pandey*1 Alka Verma2 Arvind Singh3 Aman Kumar Singh4. "Liposomes: As An Important Drug Delivery System." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 1127–36. https://doi.org/10.5281/zenodo.11236835.

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Liposomes are cosidered as an important drug delivery system with lots of clinical applications. Important discovery in drug delivery system has been begins in 1950’s with the new research study of polyclonal antitumor antibodie. Liposomes are developed by Bangham and his colleagues in early 1960’s. The term liposomes mean lipid body. These are artificially prepared a simple microspic vesicle. These vesicles are made up of phospholipid and cholesterol. Several types of drugs can be filled in liposomal formulation according to the needs of patient. It is used to deliver the medicame

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Maneri, Karishma Y* Inagle Sanjay Baride komal Latpate Manisha B. "Liposomal Nanomedicines In Cancer Therapy." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 1537–52. https://doi.org/10.5281/zenodo.13997934.

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As nanocarriers, liposomes have long been studied for their ability to deliver medications to their sites of action while lowering toxicity.Nanotechnology is among the most exciting new technologies of the twenty-first century.Phospholipids give liposomes their form. Anticancer medications, among other medications, can be delivered by liposome encapsulation. Liposomes can include both hydrophilic and hydrophobic medicines. Once closed lipid bilayer vesicles were discovered, the name liposomes was first used in 1960. As medication carriers, liposomes are helpful, but making them using organic s

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Roberts, Steven A., Chaebin Lee, Shrishti Singh, and Nitin Agrawal. "Versatile Encapsulation and Synthesis of Potent Liposomes by Thermal Equilibration." Membranes 12, no. 3 (2022): 319. http://dx.doi.org/10.3390/membranes12030319.

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The wide-scale use of liposomal delivery systems is challenged by difficulties in obtaining potent liposomal suspensions. Passive and active loading strategies have been proposed to formulate drug encapsulated liposomes but are limited by low efficiencies (passive) or high drug specificities (active). Here, we present an efficient and universal loading strategy for synthesizing therapeutic liposomes. Integrating a thermal equilibration technique with our unique liposome synthesis approach, co-loaded targeting nanovesicles can be engineered in a scalable manner with potencies 200-fold higher th

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Xiao, Dexuan, and Ronghui Zhou. "Advances in the Application of Liposomal Nanosystems in Anticancer Therapy." Current Stem Cell Research & Therapy 16, no. 1 (2021): 14–22. http://dx.doi.org/10.2174/1574888x15666200423093906.

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Cancer is the disease with the highest mortality rate, which poses a great threat to people’s lives. Cancer caused approximately 3.4 million death worldwide annually. Surgery, chemotherapy and radiotherapy are the main therapeutic methods in clinical practice. However, surgery is only suitable for patients with early-stage cancers, and chemotherapy as well as radiotherapy have various side effects, both of which limit the application of available therapeutic methods. In 1965, liposome was firstly developed to form new drug delivery systems given the unique properties of nanoparticles, such as

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Debs, R. J., N. Düzgüneş, E. N. Brunette, B. Fendly, J. Patton, and R. Philip. "Liposome-associated tumor necrosis factor retains bioactivity in the presence of neutralizing anti-tumor necrosis factor antibodies." Journal of Immunology 143, no. 4 (1989): 1192–97. http://dx.doi.org/10.4049/jimmunol.143.4.1192.

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Abstract Cell-associated TNF-alpha, either bound to its receptor on monocyte membranes or expressed as an integral membrane protein, can exert potent tumor cytolytic activity. We assessed the interaction of TNF with the lipid bilayer membrane system, liposomes, and the effects of membrane association on TNF bioactivity. High levels of TNF can be encapsulated within liposomes. At neutral pH, TNF binds to the surface of preformed liposomes (liposome-associated TNF), but does not partition into the lipid bilayer. TNF appears to bind to negatively charged phospholipid head groups of the outer memb

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Hattori, Yoshiyuki, Masataka Date, Shohei Arai, Kumi Kawano, Etsuo Yonemochi, and Yoshie Maitani. "Transdermal Delivery of Small Interfering RNA with Elastic Cationic Liposomes in Mice." Journal of Pharmaceutics 2013 (December 26, 2013): 1–6. http://dx.doi.org/10.1155/2013/149695.

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We developed elastic cationic liposomal vectors for transdermal siRNA delivery. These liposomes were prepared with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) as a cationic lipid and sodium cholate (NaChol) or Tween 80 as an edge activator. When NaChol or Tween 80 was included at 5, 10, and 15% (w/w) into DOTAP liposomal formulations (C5-, C10-, and C15-liposomes and T5-, T10-, and T15-liposomes), C15- and T10-liposomes showed 2.4- and 2.7-fold-higher elasticities than DOTAP liposome, respectively. Although the sizes of all elastic liposomes prepared in this study were about 80–90 nm, the

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Ayush, S. Jaiswal*1 Rekha Gaukande2 Gajanan Sanap3. "A Review On Liposomes As Drug Delivery System." International Journal in Pharmaceutical Sciences 1, no. 12 (2023): 926–36. https://doi.org/10.5281/zenodo.10442217.

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Liposomes are composed of phospholipids and lipids, forming spherical or multilayered vesicles with a lipid bilayer structure in aqueous solutions due to self-assembly of diacyl chain phospholipids. The number of bilayers and the size of vesicles influence the amount of drug encapsulation in liposomes, a crucial factor in determining their circulation half-life. This method involves coating a medication and a lipid onto a soluble carrier to create a pro-liposome, which is free-flowing and granular. When hydrated, it forms an isotonic liposomal solution. This pro-liposome approach serves as a m

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Damm, Dominik, Ehsan Suleiman, Hannah Theobald, et al. "Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes." Pharmaceutics 14, no. 7 (2022): 1385. http://dx.doi.org/10.3390/pharmaceutics14071385.

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Functionalization of experimental HIV-1 virus-like particle vaccines with heterologous T helper epitopes (T helper VLPs) can modulate the humoral immune response via intrastructural help (ISH). Current advances in the conjugation of native-like HIV-1 envelope trimers (Env) onto liposomes and encapsulation of peptide epitopes into these nanoparticles renders this GMP-scalable liposomal platform a feasible alternative to VLP-based vaccines. In this study, we designed and analyzed customizable Env-conjugated T helper liposomes. First, we passively encapsulated T helper peptides into a well-charac

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Gorbik, V. S., Z. S. Shprakh, Z. M. Kozlova, and V. G. Salova. "LIPOSOMES AS A TARGETED DELIVERY SYSTEM OF DRUGS (REVIEW)." Russian Journal of Biotherapy 20, no. 1 (2021): 33–41. http://dx.doi.org/10.17650/1726-9784-2021-20-1-33-41.

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Liposomal targeted drug delivery makes it possible to achieve effective concentration in the target cell under various pathological conditions. The main advantage of liposomal particles is their biodegradability and immunological neutrality, which improves the safety profile of drugs. The review provides information on the composition of liposomes: the main component of the liposomal membrane is phospholipids, which provide its strength and protect from mechanical impacts. Liposomal particles are distinguished by the size and number of bilayer membranes, also secreted liposomes with a non‑lame

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Yaroslavov, Alexander A., and Andrey V. Sybachin. "Multifunctional carriers for controlled drug delivery." Pure and Applied Chemistry 92, no. 6 (2020): 919–39. http://dx.doi.org/10.1515/pac-2019-1111.

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AbstractIn the review we describe a method for concentration of anionic liposomes with encapsulated water-soluble substances within a small volume via electrostatic liposome adsorption on the surface of polymer particles with grafted cationic chains (spherical polycationic brushes), or cationic microgel particles. Dozens of intact liposomes can be bound to each polymer particle, the resulting polymer/liposome complex does not dissociate into the original components in a physiological solution. This allows fabrication of multi-liposomal complexes (MLCs) with a required ratio of encapsulated sub

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Kan, Pei, Chih-Wan Tsao, Ae-June Wang, Wu-Chou Su, and Hsiang-Fa Liang. "A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect." Journal of Drug Delivery 2011 (October 11, 2011): 1–9. http://dx.doi.org/10.1155/2011/629234.

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A liposome formulation for paclitaxel was developed in this study. The liposomes, composed of naturally unsaturated and hydrogenated phosphatidylcholines, with significant phase transition temperature difference, were prepared and characterized. The liposomes exhibited a high content of paclitaxel, which was incorporated within the segregated microdomains coexisting on phospholipid bilayer of liposomes. As much as 15% paclitaxel to phospholipid molar ratio were attained without precipitates observed during preparation. In addition, the liposomes remained stable in liquid form at 4 for at least

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Glukhova, Olga E. "Liposome Drug Delivery System across Endothelial Plasma Membrane: Role of Distance between Endothelial Cells and Blood Flow Rate." Molecules 25, no. 8 (2020): 1875. http://dx.doi.org/10.3390/molecules25081875.

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This paper discusses specific features of the interactions of small-diameter liposomes with the cytoplasmic membrane of endothelial cells using in silico methods. The movement pattern of the liposomal drug delivery system was modeled in accordance with the conditions of the near-wall layer of blood flow. Our simulation results show that the liposomes can become stuck in the intercellular gaps and even break down when the gap is reduced. Liposomes stuck in the gaps are capable of withstanding a shell deformation of ~15% with an increase in liposome energy by 26%. Critical deformation of the mem

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