Relevant bibliographies by topics / Mesenchymal Stromal Cellls

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Mesenchymal Stromal Cellls'

Author: Grafiati
Published: 31 May 2025
Last updated: 31 July 2025

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Journal articles on the topic "Mesenchymal Stromal Cellls"

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Tian, Chen, Guoguang Zheng, M. James You, and Yizhuo Zhang. "Microrna-494 Activation Suppresses Bone Marrow Stromal Cell-Mediated Drug Resistance in Acute Myeloid Leukemia Cells." Blood 128, no. 22 (2016): 1576. http://dx.doi.org/10.1182/blood.v128.22.1576.1576.

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Abstract Acute myeloid leukemia (AML) is not sensitive to chemotherapy partially because of the protection of AML cells by mesenchymal stromal cells (MSCs). Our previous studies found that MSCs protected AML cells from apoptosis through the c-Myc-dependent pathway. However, the mechanism by which MSCs regulate c-Myc in AML cells is still unknown. To elucidate the mechanism, we performed microRNA array analysis of AML cell lines and validated by TaqMan realtime PCR. The results showed that the expression of microRNA-494 (miR-494) in AML cells after coculture with MSCs was down-regulated. Report
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Srinivas, Ampati. "The Constantly Highly Expression of Limbal Stromal Cells Compared to the Bone Marrow Mesenchymal Stromal Cells, Adipose-Derived Mesenchymal Stromal Cells and Foreskin Fibroblasts." Stem Cells Research and Therapeutics International 1, no. 1 (2019): 01–06. http://dx.doi.org/10.31579/2643-1912/005.

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Tarusin, D. "ENCAPSULATION OF MESENCHYMAL STROMAL CELLS IN ALGINATE MICROSPHERES." Biotechnologia Acta 9, no. 4 (2016): 58–66. http://dx.doi.org/10.15407/biotech9.04.058.

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Pakula, Hubert, Ryan Carelli, Nicolo Fanelli, et al. "Abstract 3816: Functional atlas of prostate mesenchyme." Cancer Research 82, no. 12_Supplement (2022): 3816. http://dx.doi.org/10.1158/1538-7445.am2022-3816.

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Abstract Prostate cancer has a heterogeneous prognosis, and genetic alterations alone do not fully explain clinical behavior. We previously characterized the stroma of localized human prostates by Laser Capture Microdissection, and found that stroma was substantially different in prostates with and without tumor. Furthermore, a stromal gene signature reflecting bone remodeling was upregulated in high compared to low Gleason grade cases. To determine how stromal cells contribute to carcinogenesis and progression we study whether specific genetic alterations in the epithelium induce unique strom
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del Carmen Rodríguez, María, Antonio Bernad, and Miguel Aracil. "Interleukin-6 deficiency affects bone marrow stromal precursors, resulting in defective hematopoietic support." Blood 103, no. 9 (2004): 3349–54. http://dx.doi.org/10.1182/blood-2003-10-3438.

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Abstract Interleukin-6 (IL-6) is a critical factor in the regulation of stromal function and hematopoiesis. In vivo bromodeoxyuridine incorporation analysis indicates that the percentage of Lin-Sca-1+ hematopoietic progenitors undergoing DNA synthesis is diminished in IL-6-deficient (IL-6-/-) bone marrow (BM) compared with wild-type BM. Reduced proliferation of IL-6-/- BM progenitors is also observed in IL-6-/- long-term BM cultures, which show defective hematopoietic support as measured by production of total cells, granulocyte macrophage-colony-forming units (CFU-GMs), and erythroid burst-fo
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Zorin, V. L., and A. I. Zorina. "To the 90th year of Alexandr Jakovlevich Friedenstein." Genes & Cells 9, no. 3 (2014): 8–10. http://dx.doi.org/10.23868/gc120254.

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The article is dedicated to the outstanding Russian scientist A.J. Friedenstein, a founder of the hematopoietic organs' stroma doctrine, a discoverer of mesenchymal stem cells (multipotent mesenchymal stromal cells, MMSC), an initiator of the tests to determine the «verity» of stem stromal cells. Discoveries of the scientist and scientific school he created are used both in the research and clinical practice all over the world.
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Kondratyuk, Roman B., Ilya S. Grekov, and Evgenii A. Seleznev. "Microenvironment influence on the development of epithelial-mesenchymal transformation in lung cancer." RUDN Journal of Medicine 26, no. 3 (2022): 325–37. http://dx.doi.org/10.22363/2313-0245-2022-26-3-325-337.

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Relevance. Epithelial-mesenchymal transformation (EMT) largely determines the biological behavior and prognosis of cancers of various localizations. It is known that the determining role in the control and implementation of the transition of the epithelial phenotype to the mesenchymal belongs to the microenvironment. At the same time, the histochemical and microscopic characteristics of stromal elements remain unclear; therefore, the aim of our study was to establish the morphological features of the stroma that affect the development of EMT in lung cancer. Materials and Methods. We studied 32
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Ratushnyy, A. Yu, та L. B. Buravkova. "ПОТЕНЦИАЛ К ДИФФЕРЕНЦИРОВКЕ МЕЗЕНХИМАЛЬНЫХ СТРОМАЛЬНЫХ КЛЕТОК ПРИ РЕПЛИКАТИВНОМ СТАРЕНИИ". Aerospace and Environmental Medicine 56, № 4 (2022): 64–69. http://dx.doi.org/10.21687/0233-528x-2022-56-4-64-69.

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Mesenchymal stromal/stem cells (MSCs) are capable of multilinear differentiation and participate in tissue homeostasis including the remodeling and reparation processes. With aging these cells more and more often activatesenescence (cell aging) that alters cell functions and microenvironment which can be the reason for age-related pathologies. One of the features of senescent MSCs is thought to be a decline of multipotency that may limit their reparative functions in tissues. The paper presents a study of the MSCs osteogenic and adipogenic potential during replicative senescence. A decline of
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Petrella, Francesco, Isabella Rimoldi, Stefania Rizzo, and Lorenzo Spaggiari. "Mesenchymal Stromal Cells for Antineoplastic Drug Loading and Delivery." Medicines 4, no. 4 (2017): 87. http://dx.doi.org/10.3390/medicines4040087.

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Mesenchymal stromal cells are a population of undifferentiated multipotent adult cells possessing extensive self-renewal properties and the potential to differentiate into a variety of mesenchymal lineage cells. They express broad anti-inflammatory and immunomodulatory activity on the immune system and after transplantation can interact with the surrounding microenvironment, promoting tissue healing and regeneration. For this reason, mesenchymal stromal cells have been widely used in regenerative medicine, both in preclinical and clinical settings. Another clinical application of mesenchymal s
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Cammarota, Francesca, and Mikko O. Laukkanen. "Mesenchymal Stem/Stromal Cells in Stromal Evolution and Cancer Progression." Stem Cells International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/4824573.

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The study of cancer biology has mainly focused on malignant epithelial cancer cells, although tumors also contain a stromal compartment, which is composed of stem cells, tumor-associated fibroblasts (TAFs), endothelial cells, immune cells, adipocytes, cytokines, and various types of macromolecules comprising the extracellular matrix (ECM). The tumor stroma develops gradually in response to the needs of epithelial cancer cells during malignant progression initiating from increased local vascular permeability and ending to remodeling of desmoplastic loosely vascularized stromal ECM. The constant
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Dissertations / Theses on the topic "Mesenchymal Stromal Cellls"

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Villard, Orianne. "Effets des cellules stromales pancréatiques immortalisées humaines sur les cellules bêta humaines." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT024.

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Introduction : L’efficacité de la greffe d’îlots n’est plus à démontrer mais elle reste l’objet de recherches pour améliorer la qualité et la survie des îlots greffés souvent fragilisés par la destruction enzymatique de leur microenvironnement lors de la procédure d’isolement. Dans ce contexte, les cellules stromales mésenchymateuses (CSM) d’origine pancréatique représentent un outil intéressant par leurs propriétés d’immunomodulation et par leur capacité de sécrétion de facteurs du microenvironnement. L’objectif de ce travail est d’évaluer l’effet des cellules stromales pancréatiques humaines
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Escobar, Pauline. "Rôle des chimiokines dans les interactions entre les cellules stromales mésenchymateuses et les cellules de cancer du sein." Thesis, Montpellier 1, 2010. http://www.theses.fr/2010MON1T019.

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Le cancer du sein est le cancer le plus fréquent chez la femme et représente un problème de santé publique majeur. L'agressivité des tumeurs mammaires varie notamment en fonction de leurstatut pour le récepteur α des oestrogènes (ERα). Les cancers du sein n'exprimant pas ERα ont unmauvais pronostic, de part leur capacité métastatique plus importante. Cependant, les facteurs sous jacents à cette plus grande agressivité des cancers ERα-négatifs restent mal compris. Il est aujourd'hui admis que la progression tumorale et la dissémination métastatique dépendent, non seulement des propriétés intrin
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Nie, Yingjie, and 聶瑛潔. "Defective dendritic cells and mesenchymal stromal cells in systemic lupus erythematosus and the potential of mesenchymal stromal cells ascell-therapy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43278681.

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PISCHIUTTA, FRANCESCA. "Mesenchymal stromal cells for traumatic brain injury." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/52353.

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The multiple pathological cascades activated after traumatic brain injury (TBI) and their extended nature offer the possibility for therapeutic interventions possibly affecting multiple injury mechanisms simultaneously. Mesenchymal stromal cell (MSC) therapy matches this need, being a bioreactor of a variety of molecules able to interact and modify the injured brain microenvironment. Compared to autologous MSCs, bank stored GMP-graded allogenic MSCs appear to be a realistic choice for TBI in a translational perspective, due to the need of delivering cell therapy in the acute phase of the path
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Daniel, Matthieu. "Interactions neuro-immunitaires et rôle des cellules stromales mésenchymateuses au cours de la COVID-19." Electronic Thesis or Diss., La Réunion, 2024. http://www.theses.fr/2024LARE0045.

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Le virus responsable du « Severe Acute Respiratory Syndrome-CoronaVirus 2 » ou SARS-CoV-2, et de la maladie nommée COVID-19 est caractérisé, sur le plan clinique, par une atteinte des voies respiratoires. Cette atteinte semble représenter un des déterminants essentiels de la sévérité et de l'évolution clinique des patients infectés. Elle peut s'accompagner d'un tableau d'hypoxémie profonde nécessitant parfois le recours à la ventilation mécanique et pouvant mener au décès. Si cette atteinte respiratoire demeure la préoccupation principale des cliniciens, elle n'est pour autant pas la seule cib
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Nie, Yingjie. "Defective dendritic cells and mesenchymal stromal cells in systemic lupus erythematosus and the potential of mesenchymal stromal cells as cell-therapy." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43278681.

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Fung, Kwong-lam, and 馮廣林. "Chemoresistance induced by mesenchymal stromal cells on cancer cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/205639.

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Human mesenchymal stromal cells (hMSCs) are part of bone marrow micro-environment that supports hematopoiesis. However, hMSCs also enhance tumor progression and survival when they become part of the cancer micro-environment. I aimed to investigate the interaction between hMSCs and cancer cells during chemotherapy. Firstly, I studied the interaction between hMSCs and T-lineage acute lymphoblastic leukemia (T-ALL) cells under pegylated arginase I (BCT-100) treatment. Three T-ALL cell lines were sensitive to BCT-100 but not hMSCs. Conversely, hMSCs could partly protect all T-ALL cell lines fro
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Roux, Clémence. "Activité immunosuppressive des cellules stromales mésenchymateuses dérivées de cellules souches pluripotentes induites humaines : induction de lymphocytes T régulateurs in vitro et in vivo et expression de PD-L1." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4226/document.

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La grande originalité de mon projet réside dans la génération de cellules stromales mésenchymateuses (MSCs) à partir de cellules souches pluripotentes induites humaines (iPS). Je rappellerai les propriétés phénotypiques, de multipotence et immunosuppressives des MSCs et m’attarderai sur leurs différents mécanismes immunomodulateurs. Cependant, leur nombre limité et leur isolation difficile limitent leur utilisation thérapeutique nécessitant une autre source de cellules.Mon travail a donc été de générer et de caractériser des MSCs issues d’iPS (huiPS-MSCs). L'avantage des huiPS-MSCs réside dans
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Pasanen, I. (Ilkka). "Stromal cells of mesenchymal origin in breast cancer." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526215587.

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Abstract Breast cancer, the most common cancer in women in Finland; its prognosis varies from very good to poor. During the last two decades, mesenchymal stromal cells, carcinoma-associated fibroblasts and normal fibroblasts of the breast have been investigated in the context of breast carcinomas because of their presence in the tumor microenvironment. It has been shown that the properties of the non-malignant tumor compartment possess prognostic value. The effects that these three stromal cell types have on cancer progression have been studied, but their exact mechanisms remain still largely
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Sory, David Roger Raymond. "Dynamic loading of periosteum-derived mesenchymal stromal cells." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/59138.

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Explosive-generated waves exhibit high-energy loading profiles featured with mechanical characteristics applied over a wide range of strain rates. Recent decades have seen unprecedented occurrence of high-energy trauma associated with blast wave exposure. One such blast-specific pathology is blast-induced heterotopic ossification (bHO), which refers to ectopic bone formation due to inappropriate mesenchymal stromal cell (MSC) osteogenesis in non-skeletal tissues. Significant effort has been made into deciphering the molecular mechanisms that allow the onset of bHO, however little research has
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Books on the topic "Mesenchymal Stromal Cellls"

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Hematti, Peiman, and Armand Keating, eds. Mesenchymal Stromal Cells. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-5711-4.

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Yildirim, Sibel. Dental Pulp Derived Mesenchymal Stromal Cells. Springer New York, 2024. http://dx.doi.org/10.1007/978-1-0716-4244-3.

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J, Prockop Darwin, Phinney Donald G, and Bunnell Bruce A, eds. Mesenchymal stem cells: Methods and protocols. Humana Press, 2008.

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Zhao, Robert Chunhua. Essentials of mesenchymal stem cell biology and its clinical translation. Springer, 2013.

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Liu, Chune. Cellular crosstalk between bone marrow-derived mesenchymal stromal cells (MSC) and pancreatic beta-cells. s.n.], 2014.

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Gross, Gerhard, and Thomas Häupl. Stem cell-dependent therapies: Mesenchymal stem cells in chronic inflammatory disorders. De Gruyter, 2013.

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1948-, Goldberg I. D., and Rosen E. M, eds. Epithelial-mesenchymal interactions in cancer. Birkhäuser Verlag, 1995.

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Mesenchymal Stromal Cells. Elsevier, 2017. http://dx.doi.org/10.1016/c2014-0-03703-3.

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Mesenchymal stem cell assays and applications. Humana Press/Springer, 2011.

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Rao, Mahendra S., Mohan C. Vemuri, and Lucas G. Chase. Mesenchymal Stem Cell Assays and Applications. Humana Press, 2017.

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Book chapters on the topic "Mesenchymal Stromal Cellls"

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Hematti, Peiman, and Armand Keating. "Mesenchymal Stromal Cells in Regenerative Medicine: A Perspective." In Mesenchymal Stromal Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5711-4_1.

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Lozito, Thomas P., and Rocky S. Tuan. "Cross-Talk Between MSCs and Their Environments." In Mesenchymal Stromal Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5711-4_10.

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Wuchter, Patrick, and Anthony D. Ho. "Human MSCs from Bone Marrow, Umbilical Cord Blood, and Adipose Tissue: All the Same?" In Mesenchymal Stromal Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5711-4_11.

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Jacamo, Rodrigo, Erika Spaeth, Venkata Battula, Frank Marini, and Michael Andreeff. "MSCs in Solid Tumors and Hematological Malignancies: From Basic Biology to Therapeutic Applications." In Mesenchymal Stromal Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5711-4_12.

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Bunnell, Bruce A., Christine Gagliardi, and Maria Isabel Ribeiro Dias. "MSC Studies in Large-Animal Models." In Mesenchymal Stromal Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5711-4_13.

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Almeida-Porada, Graça, Christopher D. Porada, and Esmail D. Zanjani. "Defining the Potential of MSCs with a Prenatal Large Animal Model." In Mesenchymal Stromal Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5711-4_14.

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Viswanathan, Sowmya, and Elizabeth J. Read. "Bench-to-Bedside Development of MSC Therapies: A Multidisciplinary Approach." In Mesenchymal Stromal Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5711-4_15.

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Hei, Derek J., and David H. McKenna. "cGMP Production of MSCs." In Mesenchymal Stromal Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5711-4_16.

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Gee, Adrian P. "MSCs: The US Regulatory Perspective." In Mesenchymal Stromal Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5711-4_17.

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Reinhardt, Jens, Egbert Flory, Isabel Büttel, et al. "MSCs: Clinical Applications and European Regulatory Aspects." In Mesenchymal Stromal Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5711-4_18.

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Conference papers on the topic "Mesenchymal Stromal Cellls"

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Nath, Peuli, Adrian Ross Liversage, Luke J. Mortensen, and Aniruddha Ray. "Perovskite contrast agent for imaging mesenchymal stromal cells in vivo." In Colloidal Nanoparticles for Biomedical Applications XX, edited by Marek Osiński and Antonios G. Kanaras. SPIE, 2025. https://doi.org/10.1117/12.3042105.

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Wang, Zenan, Yi Ding, Yuqiang Chen, et al. "Towards the Upscaling of Mesenchymal Stromal Cells Biomanufacturing Enhanced by the Automated Cell Manufacturing Platform." In 2024 IEEE International Conference on Robotics and Biomimetics (ROBIO). IEEE, 2024. https://doi.org/10.1109/robio64047.2024.10907536.

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Svirskaya, A. V., M. A. Yakauleva, D. B. Nizheharodava, and M. M. Zafranskaya. "EFFECT OF HYPOXIA ON IMMUNOMODULATORY PROPERTIES OF MULTIPOTENT MESENCHYMAL STROMAL CELLS." In SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-2-94-97.

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This study characterizes the effect of hypoxia on human multipotent mesenchymal stromal cells ability to modulate mitogen-stimulated proliferation of peripheral blood mononuclear cells, what can be used for optimization of biomedical cell products protocols using for cell therapy of pathological conditions accompanied by hypoxia.
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Serdukov, Yu V., А. Yu Adamovich, V. K. Shadrina, and D. B. Nizheharodava. "THE COMPARISON OF MULTIPOTENT MESENCHYMAL STROMAL CELLS IN DONORS OF DIFFERENT AGE GROUPS." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-111-114.

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The morpho-functional characteristics (viability, sterility, immunophenotype, proliferative and differentiation potential, immunosuppressive properties) of multipotent mesenchymal stromal cells obtained from donors of different age groups are presented in this work.
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Metzger, Thomas A., Stephen A. Schwaner, and Glen L. Niebur. "Pressure Gradients in the Trabecular Pore Space of Femurs During Physiologic Loading." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14433.

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Bone marrow is an important niche for mesenchymal stromal cells (MSCs), which are progenitors for connective tissue cells. MSCs respond to mechanical stimuli (1). For example, steady and oscillatory fluid flow both affect MSC differentiation to the osteogenic lineages (2), while hydrostatic pressure increases MSC osteogenic protein expression (3). Both pressure and fluid flow are induced in bone marrow during loading due to the poroelastic nature of trabecular bone, and these may affect the differentiation or proliferation of the resident stromal cells.
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Bobkova, Natalia Victorovna, Rimma Alekseevna Poltavtseva, Daria Jurievna Zhdanova, Vladimir Igorevich Kovalev та Alina Vadimovna Chaplygina. "THE EFFECT OF YB-1 PROTEIN IN СHIMERIC MODEL OF ALZHEIMER’S DISEASE". У NEW TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2021. http://dx.doi.org/10.47501/978-5-6044060-1-4.10.

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The paper focuses on the molecular cell interaction of human mesenchymal stromal cells with the hippocampal primary culture of transgenic XFAD mice and the effect of multifunctional YB-1 protein on the memory and state of adult neurogenesis niches in animals with a chi-meric model of Alzheimer's disease. The results suggest the usefulness of a comprehensive use of cell therapy in combination with YB-1 to activate compensatory mechanisms in patients with Alzheimer's disease.
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Falcão, Christiane Cardoso, Tânia Souza Machado da Silva, Thaynara Karoline de Souza Pereira, Clarissa Mendes Remor, and Letícia Bendo. "Mammary Myofibroblastoma: a case report and literature review." In XXVI Brazilian Mastology Congress. Mastology, 2024. https://doi.org/10.29289/259453942024v34s2011.

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Introduction: Mammary myofibroblastoma is a rare benign mesenchymal tumor of the breast. In 1981, Toker et al. reported four cases of benign stromal breast tumors with morphological features similar to fusiform cell lipoma of soft tissues and named them as benign fusiform tumors of the breast. It was later, in 1987, that the term myofibroblastoma was coined by Wargotz to describe a tumor characterized by proliferation of fusiform cells with myofibroblastic differentiation within an abundant collagenous stroma. Although typically benign, myofibroblastomas can present a wide range of clinical an
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Jacamo, Rodrigo O., Ye Chen, Zhiqiang Wang та ін. "Abstract 4264: NFκB activation in mesenchymal stromal cells induced by leukemia-stroma interaction plays a central role in stroma-mediated chemo-resistance of leukemic cells". У Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4264.

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Kulebyakina, M. A., D. A. Butuzova, N. D. Basalova, and A. Yu Efimenko. "DKK3 SECRETED BY MESENCHYMAL STROMAL CELLS PREVENTS FIBROBLAST-TO-MYOFIBROBLAST TRANSITION." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-287.

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It is well known that mesenchymal stromal cells (MSCs) prevent the development of fibrosis in a paracrine manner; still, the underlying mechanisms have not yet been studied. Using proteomic analysis, we identified the DKK3 protein, a regulator of the Wnt signaling pathway, in the MSC secretome. We also demonstrated that the DKK3 protein in the MSC secretome suppresses the canonical Wnt signaling pathway in fibroblasts and prevents myofibroblast differentiation.
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Lee, Elizabeth, Maciej Baranski, Zixin Yong, Lakshmi Venkatraman, Derrick Yong, and George Barbastathis. "Multimodal Microscopy for Label-free Monitoring of Mesenchymal Stromal Cells." In Frontiers in Optics. OSA, 2020. http://dx.doi.org/10.1364/fio.2020.fw7e.8.

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