Relevant bibliographies by topics / OXA genes

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'OXA genes'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "OXA genes"

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Higgins, Paul G., Francisco J. Pérez-Llarena, Esther Zander, Ana Fernández, Germán Bou та Harald Seifert. "OXA-235, a Novel Class D β-Lactamase Involved in Resistance to Carbapenems in Acinetobacter baumannii". Antimicrobial Agents and Chemotherapy 57, № 5 (2013): 2121–26. http://dx.doi.org/10.1128/aac.02413-12.

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ABSTRACTWe investigated the mechanism of carbapenem resistance in 10Acinetobacter baumanniistrains isolated from the United States and Mexico between 2005 and 2009. The detection of known metallo-β-lactamase or carbapenem-hydrolyzing oxacillinase (OXA) genes by PCR was negative. The presence of plasmid-encoded carbapenem resistance genes was investigated by transformation ofA. baumanniiATCC 17978. Shotgun cloning experiments and sequencing were performed, followed by the expression of a novel β-lactamase inA. baumannii. Three novel OXA enzymes were identified, OXA-235 in 8 isolates and the ami
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Towner, Kevin J., Benjamin Evans, Laura Villa та ін. "Distribution of Intrinsic Plasmid Replicase Genes and Their Association with Carbapenem-Hydrolyzing Class D β-Lactamase Genes in European Clinical Isolates of Acinetobacter baumannii". Antimicrobial Agents and Chemotherapy 55, № 5 (2011): 2154–59. http://dx.doi.org/10.1128/aac.01661-10.

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ABSTRACTNinety-six genetically diverse multidrug-resistant clinical isolates ofAcinetobacter baumanniifrom 25 hospitals in 17 European countries were screened by PCR for specific carbapenemase-hydrolyzing class D β-lactamase (CHDL) genes and by PCR-based replicon typing for the presence of 19 different plasmid replicase (rep) gene homology groups (GRs). Results were confirmed by DNA sequencing where necessary. All 96 isolates contained at least 1 (with a maximum of 4) of the 19 groups ofrepgenes. Groups detected were GR6 (repAci6; 93 isolates), GR2 (includingrepAci1 [67 isolates] andrepAci2 [3
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Poirel, Laurent, Samy Figueiredo, Vincent Cattoir, Alessandra Carattoli, and Patrice Nordmann. "Acinetobacter radioresistens as a Silent Source of Carbapenem Resistance for Acinetobacter spp." Antimicrobial Agents and Chemotherapy 52, no. 4 (2008): 1252–56. http://dx.doi.org/10.1128/aac.01304-07.

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ABSTRACT Carbapenem resistance results mostly from the expression of acquired carbapenem-hydrolyzing oxacillinases in Acinetobacter baumannii. The bla OXA-23 oxacillinase gene is increasingly reported worldwide and may represent an emerging threat. Our goal was to identify the progenitor of that carbapenemase gene. A collection of 50 Acinetobacter sp. strains corresponding to several Acinetobacter species was screened for bla OXA-23-like genes by PCR and hybridization techniques. Five Acinetobacter radioresistens isolates that were susceptible to carbapenems harbored chromosomally encoded bla
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Héritier, Claire, Laurent Poirel, Thierry Lambert, and Patrice Nordmann. "Contribution of Acquired Carbapenem-Hydrolyzing Oxacillinases to Carbapenem Resistance in Acinetobacter baumannii." Antimicrobial Agents and Chemotherapy 49, no. 8 (2005): 3198–202. http://dx.doi.org/10.1128/aac.49.8.3198-3202.2005.

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ABSTRACT Carbapenem-hydrolyzing oxacillinases are reported increasingly in Acinetobacter baumannii. Since they hydrolyze carbapenems at low levels, the roles of carbapenem-hydrolyzing oxacillinases OXA-23, OXA-40, and OXA-58 in A. baumannii were determined. The bla OXA-23, bla OXA-40, and bla OXA-58 genes were inserted in broad-host-range plasmid pAT801 and transformed in Escherichia coli DH10B and in A. baumannii CIP 70.10 and its point mutant derivative A. baumannii BM4547, which overexpresses the efflux pump AdeABC. Natural plasmids harboring the bla OXA-23 and bla OXA-58 genes were also tr
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Tacão, Marta, Isabel Silva, and Isabel Henriques. "Culture-independent methods reveal high diversity of OXA-48-like genes in water environments." Journal of Water and Health 15, no. 4 (2017): 519–25. http://dx.doi.org/10.2166/wh.2017.260.

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The carbapenemase OXA-48 was identified for the first time in 2001 and is now one of the greatest concerns in terms of antibiotic resistance. While many studies report clinical OXA-48-like producers, few reports refer blaOXA-48-like genes in environmental bacteria. The main goal of this study was to evaluate the diversity of blaOXA-48-like genes in aquatic systems, using culture-independent approaches. For that, environmental DNA was obtained from riverine and estuarine water and used to construct clone libraries of blaOXA-48-like gene polymerase chain reaction amplicons. blaOXA-48-like librar
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Sarwar, Amna, Syeda Zahra Gillani, Rana Muhammad Shahbakht та ін. "Detection of Β-Lactamase OXA Genes and Biofilm Production in Carbapenem Resistant Gram-Negative Bacilli". Pakistan Journal of Medical and Health Sciences 17, № 4 (2023): 235–38. http://dx.doi.org/10.53350/pjmhs2023174235.

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Objectives: The emergence of carbapenem resistance in biofilm producer Gram-negative bacteria poses a substantial challenge to manage infections. This study aimed to evaluate biofilm production and molecular characterization of carbapenem resistance Gram-negative rods. Methods: Total of 46 bacteria were isolated from various clinical samples, including blood, CSF, urine, sputum, saliva, tracheal secretion, and pus. Following the standard guidelines for bacterial identification (CLSI), bacterial pathogens are isolated and identified. The antibiotic susceptibility profile was obtained against co
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Karabay, Osman, Fahriye Ekşi, Mehmet Sait Yıldırım, and Deniz Gazel. "Investigation of Antibiotic Resistance Profiles and Carbapenemase Resistance Genes in Acinetobacter Baumannii Strains Isolated From Clinical Samples." European Journal of Therapeutics 28, no. 4 (2022): 252–59. http://dx.doi.org/10.58600/eurjther-28-4-0071.

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Objective: Acinetobacter baumannii is an important pathogen that can develop multiple drug resistance. Here, we aimed to investigate the antibiotic resistance profiles of A. baumannii strains isolated from the various clinics of our hospital and determine the class D beta-lactamase resistance genes causing carbapenem resistance. Methods: Between June-2016 and June-2017, 157 A. baumannii strains isolated from clinical specimens of our hospital were identified with automatic bacterial identification system and antibiograms were determined by the same system. Among the carbapenem resistant strain
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L. Aishwarya, K. V., P. V. Geetha, M. Shanthi, and S. Uma. "Co occurrence of two 16S rRNA methyltrasferases along with NDM and OXA 48 like carbapenamases on a single plasmid in Klebsiella pneumoniae." Journal of Laboratory Physicians 11, no. 04 (2019): 305–11. http://dx.doi.org/10.4103/jlp.jlp_59_19.

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Abstract BACKGROUND: The carbapenemase-encoding genes, bla NDM- and bla OXA-48 - like , confer resistance to all the known beta-lactams and are encountered along with other beta-lactamase-encoding genes and/or 16S ribosomal RNA (rRNA)-methylating genes. The co-occurrence of bla NDM and bla OXA-48 - like on a single plasmid is a rare occurrence. AIM AND OBJECTIVE: The purpose of the study was to characterize the plasmids in Klebsiella pneumoniae isolates producing 16S rRNA methyltransferase along with bla NDM , bla OXA-48-like , and other resistance encoding genes. MATERIALS AND METHODS: One-hu
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Gur, Deniz, Volken Korten, Serhat Unal, Lalitagauri M. Deshpande, and Mariana Castanheira. "Increasing carbapenem resistance due to the clonal dissemination of oxacillinase (OXA-23 and OXA-58)-producing Acinetobacter baumannii: report from the Turkish SENTRY Program sites." Journal of Medical Microbiology 57, no. 12 (2008): 1529–32. http://dx.doi.org/10.1099/jmm.0.2008/002469-0.

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A significant increase in carbapenem-resistance rates among Acinetobacter baumannii isolates collected in two Turkish medical centres was detected in the 2000–2006 period (20–60 %) by the SENTRY Antimicrobial Surveillance Program. Carbapenem-resistant strains from 2006 were evaluated for the presence of encoding genes and epidemic clonality. OXA-58-like and OXA-23-like carbapenemase-producing strains were detected in both medical institutions. Seventeen out of 18 strains from Ankara were positive for bla OXA-58 primers and belonged to the same clone, whilst 26 isolates (25 from Istanbul and on
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Wang, Hui, Ping Guo, Hongli Sun, et al. "Molecular Epidemiology of Clinical Isolates of Carbapenem-Resistant Acinetobacter spp. from Chinese Hospitals." Antimicrobial Agents and Chemotherapy 51, no. 11 (2007): 4022–28. http://dx.doi.org/10.1128/aac.01259-06.

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ABSTRACT Carbapenem resistance in Acinetobacter spp. is an emerging problem in China. We investigated the molecular epidemiology and carbapenemase genes of 221 nonrepetitive imipenem-resistant clinical isolates of Acinetobacter spp. collected from 1999 to 2005 at 11 teaching hospitals in China. Genotyping by pulsed-field gel electrophoresis (PFGE) found 15 PFGE patterns. Of these, one (clone P) was identified at four hospitals in Beijing and another (clone A) at four geographically disparate cities. Most imipenem-resistant isolates exhibited high-level resistance to all β-lactams and were only
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Dissertations / Theses on the topic "OXA genes"

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Otiniano, Cordova Chris Jordan, and Puma Xiomara Alisson Rivera. "Prevalencia de genes OXA, VIM e IMP en cepas de Acinetobacter baumannii resistentes a carbapenémicos del Hospital Nacional Hipólito Unanue. Agosto – diciembre 2019." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2021. https://hdl.handle.net/20.500.12672/16531.

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Acinetobacter baumannii es una bacteria oportunista causante de infecciones nosocomiales graves y multirresistentes. El principal objetivo del presente trabajo de investigación fue determinar la prevalencia de los genes OXAs, VIM e IMP en cepas de A. baumannii resistentes a carbapenémicos. Tipo de estudio observacional, descriptivo y transversal. Se analizaron 40 cepas clínicas de A. baumannii con un perfil de resistencia a carbapenémicos aislados en el Hospital Nacional Hipólito Unanue, Lima – Perú durante el período agosto a diciembre del 2019. Los métodos fenotípicos para determinar
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Mossakowska, Danuta Ewa Irena. "Molecular characterisation of the OXA-2 beta-lactamase." Thesis, University of Surrey, 1988. http://epubs.surrey.ac.uk/847832/.

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The DNA sequence of the gene coding for the OXA-2 beta-lactamase has been completed. The primary amino acid sequence deduced from the DNA sequence was used to study homologies with other beta-lactamases; no good homologies were observed with any class of beta-lactamase. A more detailed analysis has revealed from comparison of both primary and predicted secondary structure, that the OXA-2 beta-lactamase may be more closely related to class A enzymes. Confirmation that the OXA-2 beta-lactamase is a serine enzyme has come from the DNA sequence and the interaction with mechanism based inactivators
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Ali, Norryai A. "Expression and secretion of OXA-2 beta-lactamase by Streptomyces lividans." Thesis, University of Surrey, 1986. http://epubs.surrey.ac.uk/847196/.

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The OXA-2 beta-lactamase gene was first found on a conjugative plasmid R46 from a clinical isolate of Salmonella typhimurium. To test the expression and secretion of OXA-2 beta-lactamase in Streptomyces lividans a shuttle plasmid (pSU101) was created by fusing an Escherichia coli plasmid (pSU8) carrying the OXA-2 beta-lactamase gene with the S. lividans vector pLJ61. The OXA-2 beta-lactamase gene specified by the hybrid plasmid PSU101 was expressed in S. lividans, although at a lower level than in coli. Almost all the beta-lactamase activity was found in the culture supernatant of S. lividans,
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Lopes, Bruno Silvester. "Role of insertion sequences in the control of antibiotic resistance in Acinetobacter baumannii." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6500.

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Acinetobacter baumannii is an emerging multiresistant pathogen increasingly known to cause infections in the immuno-compromised patients. Carbapenems and colistin are considered to be the last resorts in treatment of infections involving multidrug resistant strains of A. baumannii. Resistance to carbapenems is well known due to the presence of intrinsic carbapenemase gene blaOXA-51-like, which may be governed by insertion elements, or by acquired carbapenemases like blaOXA-23-like, blaOXA-58-like or blaOXA-40-like genes, most of which are frequently associated with insertion elements. The acqu
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Zhang, Jinglan. "Genomic analysis of 12-oxo-phytodienoic acid reductase genes of Zea mays." Texas A&M University, 2004. http://hdl.handle.net/1969.1/3332.

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The 12-oxo-phytodienoic acid reductases (OPRs) are enzymes of the octadecanoid pathway which converts linolenic acid to a phytohormone, jasmonic acid. Bioinformatics analysis of ESTs and genomic sequences from available private and public databases revealed that the maize genome encodes eight different OPR genes. This number of maize OPR genes has been independently confirmed by Southern blot analysis and by mapping of individual OPR genes to maize chromosomes using oat maize chromosome addition lines. Survey of massively parallel signature sequencing (MPSS) assays revealed that transcripts o
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Bilek, Nicole. "Genetic mechanisms of opa gene variation in Neisseria gonorrhoeae." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6210.

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To understand the rates and mechanisms of Neisseria gonorrhoeae opacity (opa) gene variation, the 11 opa genes were amplified independently so that an opa allelic profile could be defined for any isolate from the sequences at each locus. Initial examination of 14 unrelated gonococcal isolates showed that no opa alleles were shared. Analysis of closely related isolates showed these typically shared most opa alleles and so the mechanisms by which recent changes occurred at individual opa loci could be determined. The great majority of changes were due to recombination among existing alleles that
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Callaghan, Martin John. "Evolutionary stability in the opa gene repertoire of Neisseria meningitidis." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400558.

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Rosa, Pamela Laiz Paré da. "Evolução dos genes da rede OXT - AVP - PRL: Aspectos moleculares, fisiológicos e comportamentais em mamíferos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/180703.

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A busca pelo repertório genético por trás de características comportamentais e reprodutivas de espécies de primatas tem desafiado nosso grupo de pesquisa. A premissa principal nesse tipo de estudo baseia-se na hipótese de que um traço fenotípico (seja ele fisiológico, comportamental, etc) compartilhado por um grupo taxonômico inteiro deve ser determinado por um repertório genético comum a esses táxons. Considerando a complexidade de muitas dessas características, temos ampliado nossos estudos para vários genes da rede OXT – AVP – PRL, usando abordagens in silico, in vitro, e in vivo. Na presen
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Andersson, Lina. "Tor, Ola, Leo och Elsa : - en diskursanalytisk studie av hur genus konstrueras i två läseböcker avsedda för grundskolans tidigare åldrar." Thesis, Linköping University, Department of Social and Welfare Studies, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7332.

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<p>Syftet med den här studien är att genom diskursanalys analysera hur genus konstrueras i två läseböcker avsedda för grundskolans tidigare åldrar. Vidare syftar uppsatsen till att undersöka huruvida konstruktionerna av genus i läromedlen förstärker och/eller bryter mot rådande genusstereotyper. Utgångspunkten för uppsatsen är teorier som ser genus, och vad vi uppfattar som kvinnligt och manligt, som sociala, kulturella, historiska konstruktioner, snarare än som biologiskt nedärvda, beständiga och oföränderliga egenskaper. Uppsatsen har ett diskursanalytiskt angreppssätt. Analysen syftar därme
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Brust, Flávia. "Detecção do gene blaOXA-23 por PCR em tempo real de aspirados traqueais de pacientes sob ventilação mecânica." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/67645.

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Introdução: O gênero Acinetobacter representa um importante patógeno relacionado a infecções hospitalares, principalmente, à pneumonia associada à ventilação mecânica (PAV). O aumento de isolados de Acinetobacter baumannii resistentes aos carbapenêmicos (ABRC) representa um problema mundial, pois limita drasticamente as opções terapêuticas. A produção da carbapenamase OXA-23, uma β-lactamase da classe D de Ambler, representa o principal mecanismo responsável por esta resistência em nosso país. Objetivo: O presente estudo tem como objetivo padronizar a técnica de PCR em tempo real (qPCR) para a
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Books on the topic "OXA genes"

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United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations. OTA report on the Human Genome Project: Hearing before the Subcommittee on Oversight and Investigations of the Committee on Energy and Commerce, House of Representatives, One Hundredth Congress, second session, April 27, 1988. U.S. G.P.O., 1988.

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Delladio, Mariano. Vapore in Val di Fiemme: Genesi di una ferrovia militare ; un contributo alla storia della ferrovia Ora-Cavalese-Predazzo. Dai primi progetti all'elettrificazione. Le locomotive ungheresi e le grandi "Mallet" germaniche. Il ruolo della Magnifica Comunità Generale. La transdolomitica Moena-St. Moritz. Calosci, 1987.

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MacGregor, Alex, Ana Valdes, and Frances M. K. Williams. Genetics of osteoarthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0044.

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In this chapter we outline the approaches which have been adopted to identify genetic variants predisposing to osteoarthritis (OA), a condition long recognized as having a heritable component. Such routes to their identification include examining mendelian traits in which OA is a feature, candidate gene studies based on knowledge of OA pathobiology, linkage analysis in related individuals, and, more recently, genome-wide association studies in large samples of unrelated individuals. It is increasingly evident that the main symptom deriving from OA—notably joint pain—also has a genetic basis bu
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52003011069. Mapping Our Genes, the Genome Projects: How Big, How Fast? (Ota-Ba Series No. 373). United States Government Printing, 1988.

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Valdes, Ana M. Genetics. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0009.

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Epidemiological studies have demonstrated that osteoarthritis (OA) is a complex trait with numerous environmental and genetic risk factors. A great deal of effort has been spent elucidating these risk factors and progress has been made. It is clear however that the causes behind OA development and progression continue to remain largely elusive. Identification of those genes that, in conjunction with environmental factors, predispose to OA severity will lead to a better understanding of the mechanisms underlying disease development and thus promote improved health strategies for prevention. An
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Walsh, David A. Contextual aspects of pain: why does the patient hurt? Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0014.

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The context in which osteoarthritis (OA) pain is experienced moderates and, to an extent, mediates its severity and impact. Context is both internal to the patient (e.g. genes, gender, age, comorbidities, psychological distress, and catastrophizing), and a consequence of external factors (e.g. social, healthcare, and work environment). Context influences how people report their pain, and also how the nervous system processes nociceptive information. Treatment contexts moderate and mediate therapeutic effectiveness, dependent on treatment expectations, beliefs, and risk evaluation. Uptake of tr
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Amazônia em Tópicos. Universidade de Brasília, 2021. http://dx.doi.org/10.26512/9786586503371.

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O Livro Amazônia em Tópicos, que ora apresentamos em seu primeiro volume, pretende disponibilizar aos leitores e às leitoras os temas abordados na disciplina organizada pelo Núcleo de Estudos Amazônicos, do Centro de Estudos Avançados Multidisciplinares, da Universidade de Brasília (NEAz/CEAM/UnB), denominada Tó picos Especiais sobre a Amazônia. Participaram da troca de conhecimentos e saberes em sala de aula, movimentos sociais, sindicatos e organizações com raízes na Amazônia que possibilitaram a aproximação à sua realidade vivida, à sua relação com a natureza e às suas lutas por melhoria de
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Maruska, Karen P., and Russell D. Fernald. Social Regulation of Gene Expression in the African Cichlid Fish. Edited by Turhan Canli. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199753888.013.012.

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How does an animal’s social environment shape its behavior and physiology, and what underlying molecular and genetic mechanisms lead to phenotypic changes? To address this question, the authors used a model system that exhibits socially regulated plastic phenotypes, behavioral complexity, molecular level access, and genomic resources. The African cichlid fishAstatotilapia burtoni, in which male status and reproductive physiology are under social control, has become an important model for studying the mechanisms that regulate complex social behaviors. This chapter reviews what is known about ho
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Book chapters on the topic "OXA genes"

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Belland, R. J., K. M. Wells, and S. G. Morrison. "The Coding Repeat Region of Gonococcal Opa Genes Forms Unusual DNA Conformations in E. coli." In Neisseriae 1990, edited by Mark Achtman, Peter Kohl, Christian Marchal, Giovanna Morelli, Andrea Seiler, and Burghard Thiesen. De Gruyter, 1991. http://dx.doi.org/10.1515/9783110867787-087.

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Taylor-Pirie, Emilie. "Imperial Aetiologies: Violence, Sleeping Sickness, and the Colonial Encounter." In Empire Under the Microscope. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-84717-3_5.

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AbstractIn this chapter Taylor-Pirie examines how one particular tropical disease—sleeping sickness—was conceptualised as a form of tropical violence across a range of medical and nonmedical genres. Using the repetition of an African curse ‘owa na ntolo’ as an access point, she reveals how sensational literary depictions of sleeping sickness circulated between newspaper reports and clinical case studies, augmenting debates about racial susceptibility. Depictions of African sleeping sickness, she argues, were filtered through an emotional register that produced new aetiologies of race and illne
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Sarkari, J. F., T. Olyhoek, M. Bopp, et al. "Class 5 proteins and opa genes in clones IV-1 and III-l of Neisseria meningitidis serogroup A." In Neisseriae 1990, edited by Mark Achtman, Peter Kohl, Christian Marchal, Giovanna Morelli, Andrea Seiler, and Burghard Thiesen. De Gruyter, 1991. http://dx.doi.org/10.1515/9783110867787-094.

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Carolina Castaño, Diana, Juan David Patiño-Salazar, and Mauricio Corredor. "Searching for the Resistance Interactome of Pseudomonas aeruginosa." In Pseudomonas aeruginosa - New Perspectives and Applications [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.108245.

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Pseudomonas aeruginosa is one of the most important emerging Gram-negative pathogenic bacilli worldwide. The development of antibiotic resistance and its ability to adapt to multiple environmental conditions keep triggering alarms in global hospitals since the invasion of different types of tissues. This facultative anaerobe can adapt easily to aerobic or anaerobic conditions. It invades tissues, such as the lung, gastrointestinal tract, skin, renal system, and urinary tract, to the extreme of causing a variety of punctate gangrene. The considerable size of its genome (core and accessory genom
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Pavoni Gomes Chagas, Thiago, Karyne Rangel, and Salvatore Giovanni De-Simone. "Carbapenem-resistant Acinetobacter baumannii in Latin America." In Acinetobacter baumannii - The Rise of a Resistant Pathogen. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1003713.

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Acinetobacter baumannii is an important bacterial pathogen associated with healthcare-associated infections (HAIs), especially in critically ill patients admitted to Intensive Care Units (ICU). Its ability to acquire antibiotic resistance determinants has propelled its clinical relevance. The rise in Acinetobacter infections and hospital outbreaks have been extensively described worldwide and are usually caused by carbapenem-resistant isolates. To compound the problem, Carbapenem-resistant A. baumannii (CRAb) isolates are also resistant to a wide range of other antibiotics, representing a seri
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McIntosh-Morgan, Venise, Karen Judith Roye-Green, Jasneth Mullings, Eberechi Patrick Akpaka, and Camille-Ann Thoms Rodriguez. "A Comprehensive Look at Carbapenemase-Producing Enterobacterales (CPE): An Urgent and Emerging Threat Posed by Carbapenemase Production." In Antimicrobial Resistance - New Insights [Working Title]. IntechOpen, 2025. https://doi.org/10.5772/intechopen.115305.

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In this chapter, we will explore and review published data on carbapenemase-producing Enterobacterales. Since the first published report of Klebsiella pneumoniae carbapenemase (KPC), other reports of carbapenemase enzymes have been reported globally and, by extension, from the English-speaking Caribbean. Several enzymes have been reported since the detection of KPC including oxacillinase (OXA)-48 like carbapenemase, Guiana extended-spectrum (GES) carbapenemase, New Delhi metallo-beta-lactamase (NDM), Verona integron-encoded metallo-beta-lactamase (VIM), and others. The ability to detect the ca
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MacGregor, Alex, Ana Valdes, and Frances M. K. Williams. "Genetics of osteoarthritis." In Oxford Textbook of Rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0044_update_001.

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In this chapter we outline the approaches which have been adopted to identify genetic variants predisposing to osteoarthritis (OA), a condition long recognized as having a heritable component. Such routes to their identification include examining mendelian traits in which OA is a feature, candidate gene studies based on knowledge of OA pathobiology, linkage analysis in related individuals, and, more recently, genome-wide association studies in large samples of unrelated individuals. It is increasingly evident that the main symptom deriving from OA—notably joint pain—also has a genetic basis bu
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Nath Srivastava, Rajeshwar, Amar Chandra Sharma, Sudeepti Ratan Srivastava, Saloni Raj, and Lavini Raj. "Genetics in Osteoarthritis Knee." In Genetic Variation. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.93890.

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Osteoarthritis (OA) is a debilitating joint disorder with a complex pathogeny wherein diverse factors interact, causing a process of deterioration of the articular cartilage and the subchondral bone. It can be primary or secondary but has common clinical, radiological, and pathological manifestations. Unfortunately, there are no curative or preventive options available for this disease. The knee is the most common site to develop OA among all synovial joints. Both environmental and genetic factors play an essential role in the initiation of the disease. Identifying the genes underlying the gen
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Marwaha, Lovleen. "Mandibular Pheromone Types, Functions, Synthesis, And Associated Genetic Elements In The Queen Honey Bee, Apis mellifera." In The Polyandrous Queen Honey Bee: Biology and Apiculture. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815079128112010008.

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Queen Mandibular Pheromones (QMP) include (E)-9-oxo-2-decanoic acid(9-ODA), (R)-and (S)-(E)-9-hydroxy-2-decanoic acid(9-HDA), methyl 4- hydroxybenzoate(HOB), 10-hydroxy-decanoic acid (10-HDAA), 4-hydroxy- -methoxyphenyl ethanol (HVA), and10-hydroxy-2 (E)-decanoic acid (10-HDA), whereas worker honey bees mandibular gland pheromones include mainly 10-hydrox- -2 (E)-decanoic acid (10-HDA),10-hydroxydecanoic acid (10-HDAA), and 2- mainly 2-heptanone (2-H), traces of 9-hydroxy-2 (E)-decanoic acid (9-HDA) and 9-ODA. Biochemical modifications of stearic acid occur through hydroxylation of stearic aci
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Li, Xiaohan, and Bing Hu. "Improvement of Oleanolic Acid Production in Saccharomyces Cerevisiae Based on OptKnock Framework." In Studies in Health Technology and Informatics. IOS Press, 2023. http://dx.doi.org/10.3233/shti230831.

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Biosynthesis of plant-derived natural products in the eukaryotic microbe Saccharomyces cerevisiae often faces the issue of the inefficient production due to the poor compatibility between the heterologous genes and chassis cells. In order to improve the biosynthetic efficiency of heterologous production of plant secondary metabolites in S. cerevisiae, people usually do metabolic engineering in and around the heterologous metabolic pathways based on researchers’ experience and mass of trials, which usually consumes a lot of manpower and financial resources. Herein, to further improve the hetero
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Conference papers on the topic "OXA genes"

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YANARDAĞ, Ayşe. "Erken Cumhuriyet Döneminde Milli İktisat Kurma Arayışı; Ticaret ve Sanayi Odaları Genel Kongresi (12 Şubat 1927-18 Şubat 1927)." In 10. Uluslararası Atatürk Kongresi. Atatürk Araştırma Merkezi Yayınları, 2024. http://dx.doi.org/10.51824/978-975-17-6042-5.08.

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Osmanlı Devleti Tanzimat Fermanından sonra devleti kurtarmak için birçok yenilikler yapmıştır. Osmanlı’nın yenilikleri yıkılmasını engellememişse de devlet ve toplum, gelenek ve tecrübeleri Türkiye Cumhuriyeti’ne miras kalmıştır. Osmanlı’nın yaptığı yenilikler içinde yetişen kuşaklar bu tecrübe ile Cumhuriyeti kurmuşlardır. Bu bağlamda ekonomi ve ticaret alanını ilgilendiren birtakım yenilikler ve kurumlar ortaya çıkmış bunlar da yeni devlete aktarılmıştır. Avrupa’daki gibi mesleki işbirliği ve dayanışmayı sağlamak üzere ticaret ve sanayi odaları kurulmuştur. İlk olarak 1880 yılında Dersaadet
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GÜLLÜ, Ramazan Erhan. "Millî Mücadele Sırasında İstanbul Merkezli Milliyetçi Siyaset Söylemlerine Karşı Mustafa Kemal Paşa’nın Tavrı." In 10. Uluslararası Atatürk Kongresi. Atatürk Araştırma Merkezi Yayınları, 2024. http://dx.doi.org/10.51824/978-975-17-6044-9.08.

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Mondros Mütarekesi’nin imzalanması sonrası İstanbul’da birçok siyasî grup, çeşitli cemiyet ve partilerle siyaset hayatına yeniden dâhil olmuşlardı. Mustafa Kemal Paşa’nın Samsun’a geçişi sonrası başlatılan Millî Mücadele hareketi İstanbul’daki siyaset hayatı üzerinde de etkiliydi. Erzurum ve Sivas kongreleri ile Millî Mücadele hareketinin kendi kurumsal yapısını oluşturması, otoritesini de güçlendirmişti. Bu gelişmeler karşısında İstanbul’da Millî Mücadele’ye tamamen karşı olan siyasî gruplarla birlikte Millî Mücadele’yi haklı ve meşru gördüğünü ifade eden, kendilerinin de milliyetçi politikal
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Lima, KO, AV Lima, and JLM Sampaio. "DETECÇÃO E CARACTERIZAÇÃO RÁPIDA DE COPRODUÇÃO DE CARBAPENEMASES E VARIANTES DE KPC EM KLEBSIELLA SPP." In Resumos do 55º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s2.8386.

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Objetivo: Desenvolver e validar um novo teste para detecção e diferenciação rápida de coprodução de carbapenemases. Método: Um total de 275 Klebsiella spp., produtoras de NDM, KPC, OXA-48-like ou coprodutoras de KPC/NDM ou NDM/OXA, teve suas espécies identificadas e a presença de genes de carbapenemases confirmada por PCR. Foram realizadas as seguintes modificações em relação ao método original CIM: 1. inclusão do imipenem-relebactam; 2. utilização de corante; 3. utilização de suspensão de E. coli ATCC 25922 com turbidez MF 3,0 para leitura em 6 horas; 4. inclusão da ceftazidima-avibactam CAZ-
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Coelho, Ana Carolina Silva, Juafran da Silveira Alves, Ana Kelly Gomes da Silva, et al. "Avaliação de índice de positividade para Acinetobacter baumannii em amostras biológicas de pacientes internados em hospital no estado do Pará." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.12516.

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Objetivo: O A. baumannii é um patógeno oportunista persistente em ambientes hospitalares e resistente a múltiplos antibióticos, representando um desafio significativo em unidades de cuidados intensivos. O estudo visou avaliar o índice de positividade para A. baumannii em várias amostras biológicas de pacientes internados, correlacionando os dados com a presença de genes de resistência e a distribuição por unidade de internação. Método: Trata-se de um estudo retrospectivo e quantitativo com dados de culturas positivas coletadas com análises de crescimento entre os anos de 2021 e 2023. As amostr
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Lima, Keila Oliveira, Aline Valério de Lima, Fabiana Teixeira, Paola Cappellano, Suely Carlos Ferreira Sampaio, and Jorge Luiz Mello Sampaio. "CIM-CD – an efficient and low-cost test for detection and differentiation of Ambler classes A, B, and D carbapenemases in Klebsiella pneumoniae complex." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.11182.

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Objective: Current phenotypic tests have limitations in detecting coproduction of carbapenemases from different Ambler classes. This study aimed to develop and validate a modified carbapenem inactivation method to address these challenges. Method: The following modifications were made: 1– use of an imipenem disk instead of meropenem; 2 – inclusion of an imipenem-relebactam disk; 3 – addition of dipicolinic acid (DPA) 4 – inclusion of Evans blue dye; 5 – use of an MF 3.0 suspension of E. coli ATCC 25922 for reading within 6 hours; 6 – adjustment of zinc sulfate (ZnSO4) concentration; 7 – inclus
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Silva, Gustavo Rosário, Anna Julia Urbano Frizera, Juliene Carla Endo Borges, et al. "Análise epidemiológica de carbapenemases entre 2021e 2024 em hospital de referência terciária de São Paulo." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.12418.

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Objetivo: O uso indiscriminado de antimicrobianos está diretamente relacionado ao aumento da resistência antimicrobiana. Os principais mecanismos relacionados aos carbapenêmicos são: alteração de permeabilidade (porinas), produção de bombas de efluxo e inativação enzimática (carbapenemases). As carbapenemases subdividem-se em dois grupos: serino carbapenemases (KPC, OXA) e metalo beta-lactamases (MBL) (NDM, IMP, VIM). A KPC é endêmica no Brasil e as MBLs são cada vez mais relatadas, demonstrando sua importância epidemiológica e diagnóstica, relacionadas à resistência contra ceftazidima-avibact
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Neitz, Jay, Maureen Neitz, and Gerald H. Jacobs. "More than three cone types in normal color vision?" In OSA Annual Meeting. Optica Publishing Group, 1990. http://dx.doi.org/10.1364/oam.1990.fm6.

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Normal human color vision is usually thought to be based on only three spectrally different cone types. However, two facts suggest the possibility that some color-normal males could have more than three cone pigment types: (1) Most people with normal color vision have more than two photopigment genes on each X-chromosome and (2) there appear to be genetically specified variations in spectral positions of the normal middle-wavelength-sensitive (MWS) and long-wavelength-sensitive (LWS) pigments. For example, a male might have one gene encoding an LWS pigment and two genes encoding slightly diffe
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Neitz, Maureen. "Molecular genetics of red-green color vision." In OSA Annual Meeting. Optica Publishing Group, 1990. http://dx.doi.org/10.1364/oam.1990.fm2.

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Genes encoding cone pigments sensitive to middle-to-long wavelengths lie in a head-to-tail tandem array on the X-chromosome. Although two X-encoded genes, one for long-wavelength-sensitive pigments and one for middle-wavelength-sensitive pigments, are sufficient to serve trichromatic color vision, most people have more than two such genes. The arrangement, location, and degree of homology of the pigment genes promote recombination within the tandem arrays. Such recombination events produce pigment-gene complements that differ in the number and sequences of individual genes and in the interrela
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Lutze, Margaret, Nancy J. Cox, and Curtis R. Brandt. "Normal color vision, linkage analysis, and visual pigment genes." In OSA Annual Meeting. Optica Publishing Group, 1990. http://dx.doi.org/10.1364/oam.1990.fm5.

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People with normal color vision show interobserver variation in Rayleigh and red-green photometric matches, which may indicate variations in photopigment spectral sensitivities and receptor populations, respectively. We have previously shown that this variation is consistent with single-gene determination. The X-chromosome visualpigment genes are good candidate genes for determination of variation in these color-vision traits; however, other genes may also contribute to cone development and function, which affect these measures.
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Lutze, Margaret, Curtis R. Brandt, Vivianne C. Smith, Joel Pokorny, and Ron G. Gregg. "Genetic studies of normal color vision." In OSA Annual Meeting. Optica Publishing Group, 1989. http://dx.doi.org/10.1364/oam.1989.fa3.

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We have studied the familial transmissions of Rayleigh match midpoints and photometric matches (667-551 nm) in observers with normal color vision to assess genetic bases for these two color vision traits (Lutze et al., in press). We first employed segregation analysis to evaluate whether each trait was consistent with determination by allelic variation of a single gene, by multiple genes (polygenic), or by environmental factors. We found that each trait was consistent with determination by a single gene. Blood samples were obtained from the majority of family members tested and DNA was isolate
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Reports on the topic "OXA genes"

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Dickman, Martin B., and Oded Yarden. Phosphorylative Transduction of Developmental and Pathogenicity-Related Cues in Sclerotinia Sclerotiorum. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7586472.bard.

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Sclerotinia sclerotiorum (Lib.) de Bary is among the world's most successful and omnivorous fungal plant pathogens. Included in the more than 400 species of plants reported as hosts to this fungus are canola, alfalfa, soybean, sunflower, dry bean, and potato. The general inability to develop resistant germplasm with these economically important crops to this pathogen has focused attention on the need for a more detailed examination of the pathogenic determinants involved in disease development. This proposal involved experiments that examined the involvement of protein phosphorylation during m
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Prusky, Dov, Noel Keen, and John Browse. Modulation of the synthesis of the main preformed antifungal compound as abasis for the prevention of postharvest disease of C. gloeosporioides in avocado fruits. United States Department of Agriculture, 2001. http://dx.doi.org/10.32747/2001.7575273.bard.

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The most important pathological factor limiting fruit life after harvest in subtropical fruits are quiescent infections of anthracnose caused by Colletotrichum gloeosporioides. Prusky and Keen elucidated the mechanism of resistance in avocado fruits to quiescent infections of C. gloeosporioides and determined that the major biocide involved is the preformed compound,1-acetoxy-2-hydroxy-4-oxo-heneicosa-13, 15 diene. Two possibilities exist for maintaining fungitoxic levels of antifungal compounds in the tissue of ripening fruits: (i). Prevention of catabolism (ii). Induction of synthesis. Previ
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Sheng, Matilda. Development of an Autologous Macrophage-based Adoptive Gene Transfer Strategy to Treat Posttraumatic Osteoarthritis (PTOA) and Osteoarithritis (OA). Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada619140.

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Amzeri, Achmad, Kaswan Badami, and Gita Pawana. Inheritance of resistance to downy mildew (Peronosclerospora maydis) in crossing of Madura Maize Plant (Zea mays L.). Innovative Scientific Information & Services Network, 2019. http://dx.doi.org/10.21107/amzeri.2019.1.

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Hybridization of Back cross is one method to get varieties that are resistant to downy mildew. The purpose of this study was to obtain information on inheritance characteristics of downy mildew resistance. This research was conducted at the experiment center of Agro-Technology Study Program of Agriculture Faculty, University of Trunojoyo Madura. Research of Assessment of resistance to Downy Mildew used a randomized block design with 18 treatments (P1, P2, F1, F2, BC1P1 and BC1P2 in three sets of crosses, namely LGL x Mdr-3, T12 x Mdr-1 and E02 x Mdr-2) and three replications so there were 54 e
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Dickman, Martin B., and Oded Yarden. Modulation of the Redox Climate and Phosphatase Signaling in a Necrotroph: an Axis for Inter- and Intra-cellular Communication that Regulates Development and Pathogenicity. United States Department of Agriculture, 2011. http://dx.doi.org/10.32747/2011.7697112.bard.

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The long-term goals of our research are to understand the regulation of sclerotial development and pathogenicity in S. sclerotiorum. The focus in this project is on the elucidation of the signaling events and environmental cues that contribute to broad pathogenic success of S. sclerotiorum. In this proposal, we have taken advantage of the recent conceptual (ROS/PPs signaling) and technical (genome sequence availability and gene inactivation possibilities) developments to address the following questions, as appear in our research goals stated below, specifically concerning the involvement of RE
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