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Relevant bibliographies by topics / Oxysterols

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Academic literature on the topic 'Oxysterols'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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Journal articles on the topic "Oxysterols"

1

Schroepfer, George J. "Oxysterols: Modulators of Cholesterol Metabolism and Other Processes." Physiological Reviews 80, no. 1 (2000): 361–554. http://dx.doi.org/10.1152/physrev.2000.80.1.361.

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Oxygenated derivatives of cholesterol (oxysterols) present a remarkably diverse profile of biological activities, including effects on sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation. The most notable oxysterol activities center around the regulation of cholesterol homeostasis, which appears to be controlled in part by a complex series of interactions of oxysterol ligands with various receptors, such as the oxysterol binding protein, the cellular nucleic acid binding protein, the sterol regulatory element binding protein, the LXR nuclear orphan receptors, and

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Diczfalusy, Ulf. "Analysis of Cholesterol Oxidation Products in Biological Samples." Journal of AOAC INTERNATIONAL 87, no. 2 (2004): 467–73. http://dx.doi.org/10.1093/jaoac/87.2.467.

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Abstract Cholesterol oxidation products, or oxysterols, have gained increased attention since it was suggested that they participate in cell signaling as ligands for the nuclear receptors liver X receptor α and β. In addition, oxysterols serve as important intermediates in bile acid biosynthesis and are also involved in cholesterol transport. Several studies have suggested that certain oxysterols may be used as markers for oxidative stress, and still other oxysterols may be of use in diagnosing neurological diseases. This broad spectrum of functions in health and disease has created a demand f

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Yuan, Xi-Ming, Nargis Sultana, Nabeel Siraj, Liam J. Ward, Bijar Ghafouri, and Wei Li. "Autophagy Induction Protects against 7-Oxysterol-induced Cell Death via Lysosomal Pathway and Oxidative Stress." Journal of Cell Death 9 (January 2016): JCD.S37841. http://dx.doi.org/10.4137/jcd.s37841.

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7-Oxysterols are major toxic components in oxidized low-density lipoprotein and human atheroma lesions, which cause lysosomal membrane permeabilization (LMP) and cell death. Autophagy may function as a survival mechanism in this process. Here, we investigated whether 7-oxysterols mixed in an atheroma-relevant proportion induce autophagy, whether autophagy induction influences 7-oxysterol-mediated cell death, and the underlying mechanisms, by focusing on cellular lipid levels, oxidative stress, and LMP in 7-oxysterol-treated macrophages. We found that 7-oxysterols induced cellular lipid accumul

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Wang, Yaping, Xiaobo Li, and Shunlin Ren. "Cholesterol Metabolites 25-Hydroxycholesterol and 25-Hydroxycholesterol 3-Sulfate Are Potent Paired Regulators: From Discovery to Clinical Usage." Metabolites 11, no. 1 (2020): 9. http://dx.doi.org/10.3390/metabo11010009.

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Oxysterols have long been believed to be ligands of nuclear receptors such as liver × receptor (LXR), and they play an important role in lipid homeostasis and in the immune system, where they are involved in both transcriptional and posttranscriptional mechanisms. However, they are increasingly associated with a wide variety of other, sometimes surprising, cell functions. Oxysterols have also been implicated in several diseases such as metabolic syndrome. Oxysterols can be sulfated, and the sulfated oxysterols act in different directions: they decrease lipid biosynthesis, suppress inflammatory

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Guo, Zhiting, Huiyan Yu, Kexin Yang, et al. "Quantitative Determination of a Series of Oxysterols by an Optimized LC-MS/MS Analysis in Different Tissue Types." International Journal of Molecular Sciences 26, no. 1 (2024): 77. https://doi.org/10.3390/ijms26010077.

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Oxysterols, as metabolites of cholesterol, play a key role in cholesterol homeostasis, autophagosome formation, and regulation of immune responses. Disorders in oxysterol metabolism are closely related to the pathogenesis of neurodegenerative diseases. To systematically investigate the profound molecular regulatory mechanisms of neurodegenerative diseases, it is necessary to quantify oxysterols and their metabolites in central and peripheral biospecimens simultaneously and accurately. However, there are a lot of unsolved problems with the existing methods, such as the hindrance of applying a s

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Griffiths, William J., Jonas Abdel-Khalik, Thomas Hearn, Eylan Yutuc, Alwena H. Morgan, and Yuqin Wang. "Current trends in oxysterol research." Biochemical Society Transactions 44, no. 2 (2016): 652–58. http://dx.doi.org/10.1042/bst20150255.

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In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the immune system, particularly with respect to bacterial and viral infection and to Th17-cell development, and the role of oxysterols in breast cancer. We also discuss the value of oxysterol analysis in the diagnosis of disease.

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Duffney, Parker F., Hye-Young H. Kim, Ned A. Porter, and Ilona Jaspers. "Ozone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors." Journal of Biological Chemistry 295, no. 36 (2020): 12727–38. http://dx.doi.org/10.1074/jbc.ra120.013699.

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Inhalation of the ambient air pollutant ozone causes lung inflammation and can suppress host defense mechanisms, including impairing macrophage phagocytosis. Ozone reacts with cholesterol in the lung to form oxysterols, like secosterol A and secosterol B (SecoA and SecoB), which can form covalent adducts on cellular proteins. How oxysterol-protein adduction modifies the function of lung macrophages is unknown. Herein, we used a proteomic screen to identify lung macrophage proteins that form adducts with ozone-derived oxysterols. Functional ontology analysis of the adductome indicated that prot

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Akiyama, Yusuke, Shunsuke Katsuki, Tetsuya Matoba, et al. "Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis." Nutrients 15, no. 13 (2023): 2997. http://dx.doi.org/10.3390/nu15132997.

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Oxysterols have been implicated in the pathogenesis of cardiovascular diseases. Serum levels of oxysterols could be positively correlated with cholesterol absorption and synthesis. However, physiological regulation of various serum oxysterols is largely unknown. The aim of this study was to investigate the relationship between clinical factors and cholesterol metabolism markers, and identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease. Subjects (n = 207) who underwent coronary stenting between 2011 and 2013 were studied cross-section

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de Freitas, Fábio Alessandro, Débora Levy, Cadiele Oliana Reichert, Edecio Cunha-Neto, Jorge Kalil, and Sérgio Paulo Bydlowski. "Effects of Oxysterols on Immune Cells and Related Diseases." Cells 11, no. 8 (2022): 1251. http://dx.doi.org/10.3390/cells11081251.

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Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on several cells, organs, and systems in the body. Oxysterols also have an influence on the physiology of the immune system, from immune cell maturation and migration to innate and humoral immune responses. In this regard, oxysterols have been involved in several diseases that have an immune component, from autoimmune and neurodegenerative diseases to inflammatory diseases, atherosclerosis, and cancer. Here, we review data on the participation of oxysterols, mainly 25-hydroxycholesterol and 7α,25-dihydroxyc

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Ridgway, N. D., P. A. Dawson, Y. K. Ho, M. S. Brown, and J. L. Goldstein. "Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding." Journal of Cell Biology 116, no. 2 (1992): 307–19. http://dx.doi.org/10.1083/jcb.116.2.307.

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A cDNA encoding a cytoplasmic oxysterol binding protein was expressed at high levels by transfection in animal cells. This protein binds oxysterols such as 25-hydroxycholesterol that regulate sterol metabolism by transcriptional and posttranscriptional effects. In the transfected cells, some of the oxysterol binding protein (OSBP) was distributed diffusely in the cytoplasm, and some was bound to small vesicles near the nucleus, as revealed by indirect immunofluorescence. Upon addition of 25-hydroxycholesterol, most of the OSBP became concentrated in large perinuclear structures that stained wi

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Dissertations / Theses on the topic "Oxysterols"

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Meaney, Steve. "Studies on oxysterols : origins, properties and roles /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-635-9.

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Meljon, Anna. "Sterols and oxysterols in brain and the immune system." Thesis, Swansea University, 2014. https://cronfa.swan.ac.uk/Record/cronfa42246.

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This project investigates sterol and oxysterol content of murine brain and macrophages. Oxysterols are oxidised forms of cholesterol implicated in a wide array of biological functions. The compounds were analysed with LC-MS LTQ-Orbitrap high resolution system, which provides a highly sensitive and accurate tool for analysis of metabolites. We profiled a sterol content of newborn murine brain and identified a broad spectrum of oxysterols. Some of these compounds are implicated in neurogenesis, a number of other oxysterols derived from desmosterol were identified in brain tissue for the first ti

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Karu, Kersti. "Analysis of Oxysterols by capillary Liquid Chromatography Tandem Mass Spectrometry." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509399.

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Chen, Yinan. "Characterization of oxysterols produced in macrophages and mechanisms of regulation." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEI102/document.

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Les macrophages jouent un rôle clé dans l'athérosclérose. Après la captation massive des LDL oxydées (oxLDL), les macrophages sous-endothéliaux sont chargés en cholestérol et se transforment ainsi en cellules spumeuses qui contribuent à la formation de la plaque d'athérome. Les oxystérols, produits d'oxydation du cholestérol, sont retrouvés en quantité importante dans les oxLDL. Au niveau cellulaire, ils sont impliqués dans la régulation de l'homéostasie du cholestérol, l'induction du stress oxydatif cellulaire et de la cytotoxicité. Notre travail montre que le cholestérol

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Wojciechowski, Jerzy Z. "Evidence of inhibition of cholesterol absorption in rats by naturally-occurring oxysterols." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq28688.pdf.

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CASULA, EMANUELA. "Probiotic Lactobacillus strains attenuate oxysterols-induced alteration of human intestinal membrane permeability." Doctoral thesis, Università degli Studi di Cagliari, 2021. http://hdl.handle.net/11584/312980.

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The intestinal membrane is an important structure which carries out central functions such as nutrient absorption and excretion and secretion of several products and acts as a barrier to protect the human body from potentially harmful compounds arriving from diet; foods are sources of both potentially dangerous and potentially protective molecules. When a noxious stimulus occurs, it can alter membrane balance and functionality, mostly by altering the tight junctions, increasing its permeability, or causing a shift on microbiota composition and thus sustaining inflammation. Inflammation and oxi

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Zhao, Kejun. "Synthesis and cytotoxity of oxysterols: studies on the A,B ring polyoxygenated sterols." Thesis, Aston University, 2002. http://publications.aston.ac.uk/10944/.

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Oxysterols (OS), the polyoxygenated sterols, represent a class of potent regulatory molecules for important biological actions. Cytotoxicity of OS is one of the most important aspects in studies of OS bioactivities. However, studies, the structure-activity relationship (SAR) study in particular, have been hampered by the limited availability of structurally diverse OS in numbers and amounts. The aim of this project was to develop robust synthetic methods for the preparation of polyhydroxyl sterols, thereof, evaluate their cytotoxicity and establish structure-activity relationship. First, we fo

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MITAROTONDA, DOMENICA. "Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease." Doctoral thesis, Università di Foggia, 2016. http://hdl.handle.net/11369/338834.

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Abstract: La NAFLD (Nonalcoholic fatty liver disease) è la più comune malattia epatica cronica dei paesi occidentali con un incidenza ancora maggiore dell’epatite virale C e del danno epatico causato dall’abuso di alcool. Dal punto di vista istologico la NAFLD include la steatosi semplice (nonalcoholic fatty liver, NAFL) nella sua forma iniziale, che può evolvere in steatoepatite (NASH), caratterizzata dalla presenza di infiltrato infiammatorio e/o di fibrosi, potenzialmente progressiva in cirrosi ,epatocarcinoma (HCC) ed insufficienza epatica. Sono stati identificati diversi eventi intracellu

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Agnoletto, Laura. "Effects of oxysterols on cell survival and proliferation pathways in human endothelial cells." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425982.

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Oxidized low density lipoproteins (ox-LDLs) are involved in the pathogenesis of atherosclerosis because of their cytotoxic and proapoptotic effect on vascular cells. However a dual effect of ox-LDL on endothelial cells (EC) has been demonstrated: they induce a proliferative effect at concentrations below 50 ?g/mL and a proapoptotic effect at concentrations above 50 ?g/mL. The cytotoxic effect of ox-LDLs has been linked to their content in oxysterols, in particular to 7beta-hydroxycholesterol and 7-ketocholesterol. These molecules have been shown to be cytotoxic to several cell lines, including

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Cindrova-Davies, Tereza. "A study of the signalling mechanisms mediating the proliferative and apoptotic effects of oxysterols." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619645.

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Books on the topic "Oxysterols"

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Lizard, Gérard, ed. Implication of Oxysterols and Phytosterols in Aging and Human Diseases. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-43883-7.

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P, Beck J., Crastes de Paulet A, and Institut national de la santé et de la recherche médicale (France), eds. Activités biologiques des oxystérols: Séminaire de recherche INSERM, Mittelwihr, 7-9 octobre 1987. Editions INSERM, 1988.

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3

Kotzka, Jörg. Charakterisierung der Wirkmechanismen des Oxysterols 25-Hydroxycholesterin auf die Acyl Coenzym A: Cholesterin Acyltransferase. [s.n.], 1996.

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Mochel, Fanny. Spastic Paraplegia Type 5. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0041.

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Spastic paraplegia type 5 (SPG5) is an autosomal recessive hereditary spastic paraplegia due to mutations in CYP7B1, which encodes oxysterol 7α‎-hydroxylase. Oxysterol 7α‎-hydroxylase is involved in the synthesis of bile acids from cholesterol. CYP7B1 mutations are responsible for rare forms of liver failure in infancy as well as lower motor neuron degeneration in adults with no obvious genotype-phenotype correlation. SPG5 is mostly characterized by spastic paraplegia with prominent posterior column sensory impairment that can lead to sensory ataxia and bladder dysfunction. SPG5 can easily be

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Fliesler, Steven J. Sterols and Oxysterols: Chemistry, Biology, and Pathobiology. Research Signpost, 2002.

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Guardiola, Francesc. Cholesterol and Phytosterol Oxidation Products. AOCS Publishing, 2002.

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Guardiola, Francesc. Cholesterol and Phytosterol Oxidation Products: Analysis, Occurrence, and Biological Effects. Taylor & Francis Group, 2002.

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Implication of Oxysterols and Phytosterols in Aging and Human Diseases. Springer International Publishing AG, 2023.

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Rozman, Damjana, and Rolf Gebhardt. Mammalian Sterols: Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids. Springer International Publishing AG, 2021.

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Rozman, Damjana, and Rolf Gebhardt. Mammalian Sterols: Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids. Springer, 2020.

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Book chapters on the topic "Oxysterols"

1

Brown, Andrew J., and Laura J. Sharpe. "Oxysterols." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-21573-6_10016-1.

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Brown, Andrew J., and Laura J. Sharpe. "Oxysterols." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_10016.

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Riols, Fabien, and Justine Bertrand-Michel. "Analysis of Oxysterols." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7592-1_19.

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Olkkonen, Vesa M. "Oxysterols and Oxysterol-Binding Proteins in Cellular Lipid Metabolism." In Cellular Lipid Metabolism. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00300-4_2.

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Foo, Cheng X., Michael B. Fessler, and Katharina Ronacher. "Oxysterols in Infectious Diseases." In Implication of Oxysterols and Phytosterols in Aging and Human Diseases. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-43883-7_7.

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de Paulet, A. Crastes, M. E. Astruc, J. Bascoul, and R. Defay. "Biological Effects of Oxysterols." In Free Radicals, Lipoproteins, and Membrane Lipids. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-7427-5_27.

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Jenner, Andrew M. "Oxysterols in Human Brain." In Encyclopedia of Lipidomics. Springer Netherlands, 2017. http://dx.doi.org/10.1007/978-94-007-7864-1_168-1.

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Iuliano, Luigi, and Ulf Diczfalusy. "Oxysterols: Potential Biomarkers of Oxidative Stress." In Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications. Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9780813814438.ch7.

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Urano, Yasuomi, and Noriko Noguchi. "Enzymatically Formed Oxysterols and Cell Death." In Implication of Oxysterols and Phytosterols in Aging and Human Diseases. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-43883-7_10.

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Raghavamenon, Achuthan C., Xueli Gao, Deidra S. Atkins-Ball, Sanjay Varikuti, Narasimham L. Parinandi, and Rao M. Uppu. "‘Ozone-Specific’ Oxysterols and Neuronal Cell Signaling." In Measuring Oxidants and Oxidative Stress in Biological Systems. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-47318-1_7.

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Conference papers on the topic "Oxysterols"

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Creaser-Thomas, J., Y. Wang, WJ Griffiths, J. Hopkin, and GA Davies. "P169 Oxysterols in asthma: a novel pilot study." In British Thoracic Society Winter Meeting 2023, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 22 to 24 November 2023, Programme and Abstracts. BMJ Publishing Group Ltd and British Thoracic Society, 2023. http://dx.doi.org/10.1136/thorax-2023-btsabstracts.320.

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Levy, Debora, Suelen Silva, Thatiana Melo, et al. "Abstract A71: Effect of oxysterols in adipose tissue-derived mesenchymal stem cell." In Abstracts: AACR International Conference held in cooperation with the Latin American Cooperative Oncology Group (LACOG) on Translational Cancer Medicine; May 4-6, 2017; São Paulo, Brazil. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1557-3265.tcm17-a71.

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Duffney, P., A. M. Speen, H. Y. H. Kim, N. A. Porter, and I. Jaspers. "Ozone-Derived Oxysterols Modulate Epithelial Cell and Macrophage Function in the Lung." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2394.

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Starkey, Nicholas J. E., Lu Yuan, Yufei Li, and Dennis B. Lubahn. "Abstract 2104: Mechanisms for the inhibition of estrogen receptors by estrogen related receptor beta and oxysterols." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2104.

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Segger, L., N. Maass, C. Eckmann-Scholz, D. Lütjohann, and U. Pecks. "Oxysterole kompensieren fetale Cholesterin-Deprivation bei IUGR." In 28. Deutscher Kongress für Perinatale Medizin. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1607810.

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Drenkhahn, Sara K., Glenn A. Jackson, Nicholas J. E. Starkey, et al. "Abstract 1520: Simvastatin alters oxysterol profiles in TRAMP mice." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1520.

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Srivastava, B., T. M. Conlon, E. Mitula, R. S. J. Sarker, and A. O. Yildirim. "Developing Oxysterol Inhibitors as a Novel Therapeutic Target for iBALT Driven Chronic Pulmonary Diseases." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3777.

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Perryman, A., H. Y. H. Kim, E. E. McNell, et al. "Electrophilic Oxysterol Production Following Ozone Exposure Within the Lung and Circulation in Healthy and Asthmatic Subjects." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3177.

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Russo, Vincenzo, Laura Raccosta, Raffaella Fontana, et al. "Abstract LB-346: The Oxysterol-CXCR2 axis plays a key role in the recruitment of tumor promoting neutrophils." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-lb-346.

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Dalenc, Florence, Luggi Iuliano, Thomas Filleron, et al. "Abstract P3-05-12: Circulating oxysterol metabolites as potential new surrogate markers for hormonotherapy in patients with hormone receptor-positive breast cancer? A pilot study." In Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 9-13, 2014; San Antonio, TX. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.sabcs14-p3-05-12.

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Reports on the topic "Oxysterols"

1

Dutta, Paresh C. Oxysterol Formation Frying Oils. AOCS, 2010. http://dx.doi.org/10.21748/lipidlibrary.39210.

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Philip Sell, Philip Sell. Developing a novel oxysterol antibiotic to combat drug-resistant tuberculosis. Experiment, 2025. https://doi.org/10.18258/77730.

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