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Dissertations / Theses on the topic 'Oxysterols'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Meaney, Steve. "Studies on oxysterols : origins, properties and roles /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-635-9.

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2

Meljon, Anna. "Sterols and oxysterols in brain and the immune system." Thesis, Swansea University, 2014. https://cronfa.swan.ac.uk/Record/cronfa42246.

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This project investigates sterol and oxysterol content of murine brain and macrophages. Oxysterols are oxidised forms of cholesterol implicated in a wide array of biological functions. The compounds were analysed with LC-MS LTQ-Orbitrap high resolution system, which provides a highly sensitive and accurate tool for analysis of metabolites. We profiled a sterol content of newborn murine brain and identified a broad spectrum of oxysterols. Some of these compounds are implicated in neurogenesis, a number of other oxysterols derived from desmosterol were identified in brain tissue for the first ti

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3

Karu, Kersti. "Analysis of Oxysterols by capillary Liquid Chromatography Tandem Mass Spectrometry." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509399.

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4

Chen, Yinan. "Characterization of oxysterols produced in macrophages and mechanisms of regulation." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEI102/document.

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Les macrophages jouent un rôle clé dans l'athérosclérose. Après la captation massive des LDL oxydées (oxLDL), les macrophages sous-endothéliaux sont chargés en cholestérol et se transforment ainsi en cellules spumeuses qui contribuent à la formation de la plaque d'athérome. Les oxystérols, produits d'oxydation du cholestérol, sont retrouvés en quantité importante dans les oxLDL. Au niveau cellulaire, ils sont impliqués dans la régulation de l'homéostasie du cholestérol, l'induction du stress oxydatif cellulaire et de la cytotoxicité. Notre travail montre que le cholestérol

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5

Wojciechowski, Jerzy Z. "Evidence of inhibition of cholesterol absorption in rats by naturally-occurring oxysterols." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq28688.pdf.

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6

CASULA, EMANUELA. "Probiotic Lactobacillus strains attenuate oxysterols-induced alteration of human intestinal membrane permeability." Doctoral thesis, Università degli Studi di Cagliari, 2021. http://hdl.handle.net/11584/312980.

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The intestinal membrane is an important structure which carries out central functions such as nutrient absorption and excretion and secretion of several products and acts as a barrier to protect the human body from potentially harmful compounds arriving from diet; foods are sources of both potentially dangerous and potentially protective molecules. When a noxious stimulus occurs, it can alter membrane balance and functionality, mostly by altering the tight junctions, increasing its permeability, or causing a shift on microbiota composition and thus sustaining inflammation. Inflammation and oxi

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7

Zhao, Kejun. "Synthesis and cytotoxity of oxysterols: studies on the A,B ring polyoxygenated sterols." Thesis, Aston University, 2002. http://publications.aston.ac.uk/10944/.

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Oxysterols (OS), the polyoxygenated sterols, represent a class of potent regulatory molecules for important biological actions. Cytotoxicity of OS is one of the most important aspects in studies of OS bioactivities. However, studies, the structure-activity relationship (SAR) study in particular, have been hampered by the limited availability of structurally diverse OS in numbers and amounts. The aim of this project was to develop robust synthetic methods for the preparation of polyhydroxyl sterols, thereof, evaluate their cytotoxicity and establish structure-activity relationship. First, we fo

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8

MITAROTONDA, DOMENICA. "Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease." Doctoral thesis, Università di Foggia, 2016. http://hdl.handle.net/11369/338834.

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Abstract: La NAFLD (Nonalcoholic fatty liver disease) è la più comune malattia epatica cronica dei paesi occidentali con un incidenza ancora maggiore dell’epatite virale C e del danno epatico causato dall’abuso di alcool. Dal punto di vista istologico la NAFLD include la steatosi semplice (nonalcoholic fatty liver, NAFL) nella sua forma iniziale, che può evolvere in steatoepatite (NASH), caratterizzata dalla presenza di infiltrato infiammatorio e/o di fibrosi, potenzialmente progressiva in cirrosi ,epatocarcinoma (HCC) ed insufficienza epatica. Sono stati identificati diversi eventi intracellu

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9

Agnoletto, Laura. "Effects of oxysterols on cell survival and proliferation pathways in human endothelial cells." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425982.

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Oxidized low density lipoproteins (ox-LDLs) are involved in the pathogenesis of atherosclerosis because of their cytotoxic and proapoptotic effect on vascular cells. However a dual effect of ox-LDL on endothelial cells (EC) has been demonstrated: they induce a proliferative effect at concentrations below 50 ?g/mL and a proapoptotic effect at concentrations above 50 ?g/mL. The cytotoxic effect of ox-LDLs has been linked to their content in oxysterols, in particular to 7beta-hydroxycholesterol and 7-ketocholesterol. These molecules have been shown to be cytotoxic to several cell lines, including

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10

Cindrova-Davies, Tereza. "A study of the signalling mechanisms mediating the proliferative and apoptotic effects of oxysterols." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619645.

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11

Ubhayasekera, S. J. Kumari A. "Sterols and oxysterols : occurrence and analysis in by-products feed fats and animal tissues /." Uppsala : Dept. of Food Science, Swedish University of Agricultural Sciences, 2009. http://epsilon.slu.se/200947.pdf.

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12

Mitić, Tijana. "Role of murine 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) in the metabolism of 7-oxysterols". Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4416.

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7-Oxysterols constitute the major component (40%) of oxidized low-density lipoprotein (oxLDL). They arise in the body via auto-oxidation of cholesterol and are known to induce endothelial dysfunction, oxidative stress and apoptosis in the vascular wall, prior to development of atherosclerosis. A novel pathway has been described for hepatic inter-conversion of 7-ketocholesterol (7-KC) and 7β -hydroxycholesterol (7β OHC) by the enzyme 11β-hydroxysteroid dehydrogenase type-1 (11β HSD1), better known for metabolizing glucocorticoids. Inhibition of 11βHSD1 is atheroprotective and the potential unde

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13

Ouimet, Mireille. "Regulation of Lipid Droplet Cholesterol Efflux from Macrophage Foam Cells: a Role for Oxysterols and Autophagy." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20399.

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Macrophage foam cells are the major culprits in atherosclerotic lesions, having a prominent role in both lesion initiation and progression. With atherosclerosis being the main factor underlying cardiovascular complications, there is a long-standing interest on finding ways to reverse lipid buildup in plaques. Studies have shown that promoting reverse cholesterol transport (RCT) from macrophage foam cells is anti-atherogenic because it alleviates the cholesterol burden of the plaques. The goal of this thesis was to gain insight into the mechanisms that govern cholesterol efflux from macrophage

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14

Telesford, Dana-Marie Leslie-Ann. "Interfacial Behavior of Cholesterol, 7-Ketocholesterol and 5ß,6ß-Epoxycholesterol in Phosphatidylcholine Monolayers." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417701383.

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15

Alrosan, Amjad. "Characterization of Interacting Partners of ABC Lipid Transporters." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/22999.

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This thesis outlines a series of experimental approaches that aim to investigate the roles of the co-factor Alix (apoptosis-linked gene 2-interacting protein X), the deubiquitinase USP9X (Ubiquitin-specific protease 9, X-linked), and sterols, including cholesterol synthesis intermediates and oxysterols, in the post-translational regulation of ATP-binding cassette (ABC) lipid transporters, ABCG1 and ABCG4. Alix and USP9X were identified in our laboratory using peptide mass spectrometry analysis as binding partners of ABCG1. The experiments presented in the following chapters characterize the ef

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16

SERRA, GESSICA. "Harmful effect of oxysterols in the gut and at systemic level: modulatory activity of olive oil phenolics." Doctoral thesis, Università degli Studi di Cagliari, 2015. http://hdl.handle.net/11584/266371.

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A healthy and proper diet is essential to prevent the onset of various diseases, as with the diet we can also introduce harmful substances. Among others, the oxysterols are particularly relevant; they can be absorbed from the diet and are the oxidized products of cholesterol present in cholesterol-containing foodstuffs after cooking, processing and storage, such as meat, fish, dairy products and eggs. They can be also generated endogenously from either the spontaneous or enzymatic oxidation of cholesterol. Oxysterols have been shown to exert several in vitro and in vivo biochemical activitie

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17

Freeman, Natalie Elaine. "The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etd/1063.

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Oxidized low-density lipoproteins (OxLDL) mediate many of the pathological events associated with atherosclerosis. Oxysterols, the major cytotoxic component of OxLDL, induce apoptosis in macrophages by a calcium flux mediated activation of cytosolic phospholipase A2 resulting in the release of arachidonic acid (AA). Inhibition of AA metabolism has been shown to protect macrophages from oxysterol-induced apoptosis. The current study explores the steps in the oxysterol-induced apoptosis signaling pathway in murine macrophages subsequent to the liberation of AA. To elucidate this mechanism, tw

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18

Leoni, Valerio. "On the possible use of oxysterols for the diagnosis and evaluation of patients with neurological and neurodegenerative diseases /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-255-1/.

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19

Poggiani, Chiara. "The effects of oxysterols on cell viability in vascular endothelial and smooth muscle cells: role of reactive oxygen species." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425987.

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Oxidized low density lipoproteins (oxLDLs) are involved in the pathogenesis of atherosclerosis and the cytotoxicity of oxLDLs has been linked to the formation of oxysterols (Schroepfer et al, 2000). 7-ketocholesterol (7-KC) and 7- hydroxycholesterol (7-OHC) are the major oxysterols found in oxLDLs. High concentrations (> 20 ?g/ml) of 7-KC and 7-OHC have been shown to induce apoptosis in human endothelial cells (Lizard et al, 1999). Preliminary results obtained in our laboratory have shown that 7-OHC and 7-KC, at concentrations below 20 ?g/mL, induce an increase in cell viability. Furthermore,

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20

ADAMCZYK, MONIKA. "Effet de oxysterols sur le glioblastome induit dans le systeme nerveux du rat : effet antiproliferant, antitumoral et mecanisme d'action." Université Louis Pasteur (Strasbourg) (1971-2008), 1998. http://www.theses.fr/1998STR13109.

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Le but de ce travail etait d'etudier : (1) le mecanisme d'action de l'effet antiproliferant du 7-hydroxycholesterol (7-ohch) sur la lignee cellulaire c6 (glioblastome de rat), au niveau de l'activite des mapk ; (2) l'effet antitumoral du 7-ohch et de certains de ses analogues, bloques par une fonction ester ou ether en c-3-oh, sur des glioblastomes de type c6, induits dans le cerveau de rat. In vitro, nous avons utilise trois modeles cellulaires : (1) des astrocytes de rat normaux ; (2) des astrocytes normaux traites par le dibutiryl-ampc (astrocytes reactifs) ; (3) des cellules de type c6. En

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21

Alkazemi, Dalal Usamah Zaid. "Modulating factors of serum oxysterol concentrations in daughters from gestational diabetes and non-gestational diabetes." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100757.

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Pregestational and gestational diabetes (GDM) places the mother and her offspring at an increased risk for later development of insulin resistance and type 2 diabetes. Oxidative stress may mediate long-term disturbances in glucose homeostasis associated with type 2 diabetes and the metabolic syndrome. This thesis describes a cross-sectional study examining serum concentrations of free radical generated oxysterols as markers of oxidative stress in a cohort of teenage daughters from pregnancies with and without GDM. Daughters of GDM-pregnancies had a tendency of higher levels of serum oxysterols

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22

Nedelcu, Daniel. "Smoothened regulation in the Hedgehog signaling pathway." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11080.

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Hedgehog signaling is a pathway essential in embryonic development, adult stem cell maintenance, and is implicated in the formation and progression of cancer. Signaling in this pathway is triggered when the secreted protein Hedgehog binds to its membrane receptor, Patched. Patched normally inhibits the seven-spanner transmembrane protein Smoothened (Smo). Binding of Hedgehog inhibits Patched resulting in Smo derepression. Active Smo then triggers the activation of the cytoplasmic steps of the signaling pathway.

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23

BOCHELEN, DAMIEN. "Effet des oxysterols sur les astrocytes reactifs : inhibition de la gliose reactionnelle induite dans le systeme nerveux central du rat et mecanisme d'action." Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR13123.

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L'intensite de la gliose reactionnelle induite par une lesion electrolytique dans le cortex de rats ages de 6 jours ou adultes est reduite de 50% et 30% respectivement par l'injection in situ de 3 nmoles de 7b-oh-cholesteryl-3-oleate. A proximite de la lesion 50% des astrocytes reactifs se divisent et l'injection de ce compose reduit de 50% cette proliferation. Les etudes de structure/activite indiquent que la fonction 7b-oh est indispensable. La lesion induit une accumulation de cholesterol plasmatique et une inhibition de la cholesterogenese; le 7b-oh-ch et ses analogues amplifient ce phenom

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24

Liu, June. "Role of macrophage apoptosis in atherosclerosis." [Johnson City, Tenn. : East Tennessee State University], 2004. http://etd-submit.etsu.edu/etd/theses/available/etd-1109104-011324/unrestricted/LiuJ111804f.pdf.

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Thesis (Ph.D.)--East Tennessee State University, 2004.<br>Title from electronic submission form. ETSU ETD database URN: etd-1109104-011324 Includes bibliographical references. Also available via Internet at the UMI web site.

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25

CABBOI, BARBARA. "Effetto pro-ossidante e pro-infiammatorio degli ossisteroli in cellule intestinali: attività modulatoria della frazione fenolica del vino." Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266441.

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Because the intestine sits at the interface between the organism and its luminal environment, it represents a critical defense barrier against luminal toxic agents. Thus, in addition to being exposed to luminal nutrients, the intestinal mucosa is constantly challenged by diet-derived oxidants, mutagens, and carcinogens as well as by endogenously generated reactive oxygen species. Among the oxidizing agents cholesterol oxidation products, oxysterols, are particularly relevant; besides being generated endogenously, they may be introduced with the diet. Oxysterols are involved in physiological pr

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26

Ferderbar, Simone. "Determinação dos óxidos de colesterol em pacientes diabéticos e intolerantes à glicose." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-02062010-104928/.

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O estresse oxidativo pode desempenhar um papel importante na etiologia das complicações no diabetes mellitus. O aumento da produção de espécies oxidantes promove modificações em moléculas endógenas, incluindo o colesterol. Os óxidos de colesterol (Cox) são formados a partir da oxidação do colesterol, por processos enzimáticos e por processos mediados por radicais livres, apresentando importantes efeitos biológicos que podem contribuir para o desenvolvimento do processo aterosclerótico no diabetes. Nesse estudo determinou-se as concentrações dos Cox, em pacientes diabéticos e indivíduos intoler

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27

Arnal, Maud. "Bis(Monoacylglycéro)Phosphate, oxystérols et ORP11 : un trio régulateur du trafic du cholestérol dans les macrophages." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10288/document.

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L'athérosclérose est une complication cardiovasculaire majeure des maladies liées à une augmentation du stress oxydatif, comme le diabète de type 2 et le syndrome métabolique. Dans ces situations, les lipoprotéines de faible densité (LDL) subissent une oxydation et leur forte absorption induit une accumulation de cholestérol dans les macrophages sous-endothéliaux. D'autre part, les LDL oxydées sont enrichies en produits d'oxydation du cholestérol appelés oxystérols, dont certains sont impliqués dans la capacité des LDL oxydées à induire un stress oxydant cellulaire et une cytotoxicité, princip

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28

Musman, Julien. "L’accumulation du cholestérol et des oxystérols mitochondriaux lors de la reperfusion du myocarde ischémique : mécanismes et implication dans la cardioprotection." Thesis, Paris Est, 2017. http://www.theses.fr/2017PESC0016/document.

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L’infarctus du myocarde représente un problème de santé publique dont le traitement de choix consiste à restaurer le flux sanguin (reperfusion) à travers le tissu ischémié dans les plus brefs délais, cependant cette procédure s’accompagne de lésions supplémentaires dont les mécanismes ne sont pas totalement connus. Notre laboratoire a observé que la reperfusion du myocarde s’accompagne d’une accumulation de cholestérol et d’oxystérols dans les mitochondries qui sont impliquées dans l’apparition de ces lésions. L’objectif de ce projet de thèse a donc été d’identifier les mécanismes responsables

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29

Pannecoucke, Xavier. "Synthese de phosphodiesters mixtes oxysterol-sucre, une premiere approche pour un ciblage tissulaire. Etudes physicochimiques des interactions oxysterol-membrane." Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR13166.

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Les oxysterols, une famille de composes naturels resultant de l'oxydation du cholesterol, sont tres repandus dans la nature. Ces sterols sont des composes doues de nombreuses activites biologiques, en particulier antitumorales. De part leur lipophilie, l'etude de l'activite biologique de ces composes in vivo est tres difficile. Pour remedier a cet inconvenient, des derives hydrosolubles du 7b-hydroxycholesterol (oxysterol ayant la plus forte activite antitumorale) ont ete synthetises sous forme de phosphate de nucleosides. Pour diminuer les effets biologiques secondaires, l'une des solutions e

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30

Fall, Fanta. "Étude métabolomique de la polarisation des macrophages pulmonaires humains A split-range acquisition method for the non-targeted metabolomic profiling of human plasma with hydrophilic interaction chromatography - high-resolution mass spectrometry Metabolomic changes during the M1- and M2-polarization of human lung macrophages." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLV064.

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Les macrophages pulmonaires sont des cellules immunitaires essentielles pour la défense contre les agents pathogènes qui colonisent les voies respiratoires et sont aussi impliqués dans la physiopathologie des maladies pulmonaires inflammatoires telles que l’asthme. Les macrophages peuvent être sujets à une polarisation vers deux phénotypes appelés M1 et M2. Le phénotype M1 est induit par les agonistes des Toll-like Récepteurs et promeut la réponse inflammatoire tandis que le phénotype M2 est induit par les cytokines Th2 canoniques IL-4 et IL-13 et exerce principalement des fonctions immunorégu

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31

Drbal, Abed Alnaser A. A. "Studies on Bioactive Lipid Mediators Involved in Brain Function and Neurodegenerative Disorders. The effect of ¿-3PUFA supplementation and lithium treatment on rat brain sphingomyelin species and endocannabinoids formation; changes in oxysterol profiles in blood of ALS patients and animal models of ALS." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6285.

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Lipids are important for structural and physiological functions of neuronal cell membranes. They exhibit a range of biological effects many are bioactive lipid mediators derived from polyunsaturated fatty acids such as sphingolipids, fatty acid ethanolamides (FA-EA) and endocannabinoids (EC). These lipid mediators and oxysterols elicit potent bioactive functions in many physiological and pathological processes of the brain and neuronal tissues. They have been investigated for biomarker discovery of ageing, neuroinflammation and neurodegenerative disorders. The n-3 fatty acids EPA and DPA are t

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32

Drbal, Abed Alnaser Anter Amer. "Studies on bioactive lipid mediators involved in brain function and neurodegenerative disorders : the effect of ω-3PUFA supplementation and lithium treatment on rat brain sphingomyelin species and endocannabinoids formation : changes in oxysterol profiles in blood of ALS patients and animal models of ALS". Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6285.

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Lipids are important for structural and physiological functions of neuronal cell membranes. They exhibit a range of biological effects many are bioactive lipid mediators derived from polyunsaturated fatty acids such as sphingolipids, fatty acid ethanolamides (FA-EA) and endocannabinoids (EC). These lipid mediators and oxysterols elicit potent bioactive functions in many physiological and pathological processes of the brain and neuronal tissues. They have been investigated for biomarker discovery of ageing, neuroinflammation and neurodegenerative disorders. The n-3 fatty acids EPA and DPA are t

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33

Bedi, Shimpi. "Identification of Novel Ligands and Structural Requirements for Heterodimerization of the Liver X Receptor Alpha." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1495630797912988.

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34

Nguyen, KhanhLinh T. "Design, synthesis and biological evaluation of oxysterol derivatives as potential therapeutic intervention for osteoporosis." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1997737691&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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35

Lu, Hongjin. "Study of the interferon-oxysterol antiviral response and 3-Hydroxy-3-Methylglutaryl-CoA Reductase." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25700.

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The oxysterol, 25-hydroxycholesterol (25-HC), is important for sterol metabolism and emerging evidence suggests that 25-HC plays a more critical role in immunity and infection. However, the precise antiviral mechanism and the target of 25- HC remains unclear. Here efforts were made to investigate the link between viral infection and the triggering of the 25-HC associated interferon (IFN) response, and how this dynamically alters the endogenous level of 3-hydroxy- 3-methylglutaryl-CoA reductase (HMGCR), a key enzyme that catalyses the production of the precursor of cholesterol and oxysterols. I

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36

Yang, Lin. "The signaling pathway of oxysterol induced apoptosis in Chinese hamster ovary (CHO)-K1 cells." [Johnson City, Tenn. : East Tennessee State University], 2002. http://etd-submit.etsu.edu/etd/theses/available/etd-0510102-161626/unrestricted/YangL062602.pdf.

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37

Laitinen, Saara. "Family of human oxysterol binding protein homologues : ORP2 is a new regulator of cellular lipid metabolism." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kansa/vk/laitinen/.

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38

Zeng, Bin. "Functional characterization of acyl-CoA binding protein (ACBP) and oxysterol binding protein-related proteins (ORPS) from Cryptosporidium parvum." Thesis, [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1211.

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39

Darbyson, Angie L. "ORP-3 Rescues ER Membrane Expansions Caused by the VAPB-P56S Mutation in Familial ALS." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/29054.

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A mutation in ER membrane protein VAPB is responsible for causing a familial form of ALS (ALS8). The VAPB-P56S mutation causes protein aggregation and a nuclear envelope defect, where retrograde transport is disrupted. Over-expression of a FFAT peptide from OSBP1 reduces the size of VAPB-P56S aggregates and restores retrograde transport. A screen was performed on FFAT-motif containing ORPs to determine if any could rescue the mutant phenotype. ORP3 successfully reduced aggregate size and restored transport to the nuclear envelope. ER membrane protein Sac1, a PI4P phosphatase cycles between

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40

Hsieh, Wei Yuan. "Functional characterisation of the host sterol metabolic network in the interferon antiviral response." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/16187.

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Sterols play many important roles in physiology, including maintaining cell membrane integrity, and producing vitamin D and steroid hormones. Recent studies implicate sterol metabolism in the host innate immune response. Previous work, based on transcriptional profiling studies of mouse cytomegalovirus (MCMV) infection of primary bone-marrow-derived macrophages (BMDM, MΦ), uncovered a previously uncharacterized role of interferon in regulating the cholesterol pathway. Notably, Toll-like receptor (TLR) induced interferon modulates the suppression of SREBP2 (Sterol Regulatory Element-Binding Pro

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41

Duran, Marie-Josée. "Influence des lipides sur la na,k-atpase endotheliale : implication dans l'atherosclerose (doctorat : endocrinologie cellulaire et moleculaire)." Aix-Marseille 2, 2000. http://www.theses.fr/2000AIX20662.

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Jurado, Marcia Cristiane. "Efeito dos oxisteróis na sinalização através de cavéolas e sua relevância na aterosclerose." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-23032011-181335/.

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Oxisteróis (por exemplo, 7hidroxicolesterol) são gerados por modificações oxidativas que ocorrem na molécula de colesterol. Podem ser encontrados em elevados níveis plasmáticos em pacientes com aterosclerose e como componentes da placa aterosclerótica. Considerando que o colesterol é o principal componente da cavéola (domínios específicos da membrana plasmática que ancoram diversas proteínas de sinalização) formulamos a hipótese que os oxisteróis podem ser incorporados a estes domínios, interferindo com as vias de sinalização aí localizadas. Células endoteliais de veia umbilical humana (HUVECs

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Boumhras, Mohamed. "Evaluation de la toxicité de moules de 2 sites de la Côte Atlantique Marocaine (Jorf Lasfar et Oualidia) utilisées comme bioindicateurs de contamination : étude in vivo et in vitro sur des rats et des cellules β-pancréatiques murines (MIN-6)". Thesis, Dijon, 2012. http://www.theses.fr/2012DIJOS118/document.

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Des substances toxiques générées par les activités portuaires, urbaines et industrielles sont déversées à certains niveaux du milieu marin côtier marocain. Les mollusques peuvent concentrer les polluants et avoir des effets néfastes sur la santé humaine par l’intermédiaire de la chaîne alimentaire. Malgré le renforcement des mesures de sécurité alimentaire, l’implication de la pollution chimique des aliments dans les troubles métaboliques n’est pas à exclure. Pour prédire l’impact des polluants sur l’écosystème aquatique et sur la santé humaine, le développement d’outils de biosurveillance est

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Virginio, Vitor Wilson de Moura 1989. "Identificação e quantificação de oxisteróis em ateromas e plasma de indivíduos com doença arterial periférica oclusiva submetidos à cirurgia de amputação." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308160.

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Orientadores: Andrei Carvalho Sposito, Eliana Cotta de Faria<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-25T15:58:25Z (GMT). No. of bitstreams: 1 Virginio_VitorWilsondeMoura_M.pdf: 2355466 bytes, checksum: 77d04b1ff5936c26cd64f6d516447ff7 (MD5) Previous issue date: 2014<br>Resumo: Atualmente aproximadamente 17 milhões de pessoas morrem por doenças cardiovasculares (DCV). No Brasil durante 2011 ocorreram cerca de 200 mil óbitos por DCV principalmente em decorrência da aterosclerose, classificada como uma d

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Shackleford, Ghjuvan'Ghjacumu. "Impacts des oxystérols par le biais des LXRs et du AhR dans la myélinisation." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P638/document.

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La formation de la gaine de myéline est un processus complexe et finement régulé. Une altération de l’expression des gènes codant pour les protéines structurales de cette gaine entraine de graves neuropathies démyélinisantes. Notre objectif est d’identifier de nouvelles voies de signalisation capables de moduler l’expression de ces gènes. Les cellules de Schwann et les oligodendrocytes contiennent et synthétisent de grande quantité de dérivés oxydés du cholestérol : les oxystérols. Ces molécules sont connues pour leurs rôles dans le maintien de l’homéostasie du cholestérol et dans la progressi

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Dacquay, Louis. "The Role of lysine Acetylation on the Regulation of Phospholipid Homeostasis in Yeast." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35867.

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Actively proliferating cells constantly monitor and re-adjust their metabolic pathways to ensure the replenishment of phospholipids necessary for membrane biogenesis and intracellular trafficking. In Saccharomyces cerevisiae, multiple studies have suggested that lysine acetylation has a role in coordinating phospholipid metabolism, yet its contribution towards phospholipid homeostasis remains uncharacterized. In this study we undertook a genetic screen to explore the connection between lysine acetylation and phospholipid homeostasis. We found that mutants of the lysine acetyltransferase comple

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Ferreira, Guilherme da Silva. "Treinamento físico aeróbio altera seletivamente a concentração e o metabolismo arterial de óxidos de colesterol e reduz colesterol na aorta de camundongos dislipidêmicos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-29112017-085932/.

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Os óxidos de colesterol modulam o desenvolvimento da aterosclerose por mediarem a síntese, captação e exportação de colesterol, além de inflamação e citotoxicidade na parede arterial. O exercício físico regular previne e regride a lesão aterosclerótica, por melhorar o perfil lipídico, transporte reverso de colesterol e defesas antioxidantes. A proteína cinase ativada por AMP (AMPK) é um importante mediador dos efeitos metabólicos do exercício físico. Em macrófagos, sua ativação vincula-se ao aumento no efluxo de colesterol e diminuição na captação de LDL. Entretanto, não está claro se o treina

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Silva, Suelen Feitoza. "Ação dos oxisteróis nos processos de proliferação e morte das células-tronco mesenquimais derivadas de tecido adiposo." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5167/tde-19062017-115114/.

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As células-tronco mesenquimais são células multipotentes caracterizadas pela capacidade de autorrenovação e diferenciação. Os oxisteróis abrangem um grande grupo heterogêneo derivado do colesterol pela da oxidação enzimática e não enzimática. Os efeitos dos oxisteróis no processo de morte celular, incluindo citotoxicidade e indução de apoptose, foram descritos em diversas linhagens celulares. No entanto, os efeitos dos oxisteróis são pouco conhecidos nas células-tronco mesenquimais. O 7-cetocolesterol (7-KC), um dos mais importantes oxisteróis, foi mostrado ser citotóxico em células-tronco mes

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Ong, Kai Li. "SNFing Glucose to PASs Mitochondrial Dysfunction: The Role of Two Sensory Protein Kinases in Metabolic Diseases." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8587.

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Mitochondria is no longer viewed as merely a powerhouse of the cell. It is now apparentthat mitochondria play a central role in signaling, maintaining cellular homeostasis and cell fate.Mitochondrial dysfunction has been linked to many human diseases caused by cellular metabolicderegulation, such as obesity, diabetes, neurodegenerative disease, cardiovascular disease andcancer. Eukaryotic organisms have evolved an efficient way in sensing, communicating andresponding to cellular stress and regulating mitochondrial activity correspondingly through acomplex network of intercommunicating protein

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Nury, Thomas. "modifications peroxysomales associées à l'oxyapoptophagie induite par le 7-cétocholestérol et identification de lipides cytoprotecteurs." Thesis, Bourgogne Franche-Comté, 2020. http://www.theses.fr/2020UBFCK034.

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Le stress oxydant est souvent augmenté dans plusieurs maladies comme des maladies liées à l’âge (maladies cardiovasculaires, maladies oculaires (dégénérescence maculaire liée à l’âge (DMLA) et cataracte), des maladies neurodégénératives (Maladie d’Alzheimer, sclérose en plaques), des maladies inflammatoires chroniques (maladies inflammatoires chroniques de l’intestin (MICI)) ainsi que certaines maladies génétiques rares (maladie de Niemann Pick, adrénoleucodystrophie liée à l’X (X-ALD)). Le stress oxydant peut oxyder différentes molécules, notamment le cholestérol présent dans les membranes li

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