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1

J, Meredith T., World Health Organization, Commission of the European Communities., and International Program on Chemical Safety., eds. Antidotes for poisoning by paracetamol. Cambridge: Published by Cambridge University Press on behalf of the World Health Organization and of the European Commission, 1995.

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2

N, Gregg, and Great Britain. Health and Safety Executive., eds. Paracetamol: Criteria document for an occupational exposure limit. London: HSE Books, 1994.

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3

Kiel, Universität, ed. Regionalanästhesie (Ilioinguinalblock) versus systemische Analgesie (Paracetamol): Vergleichende Untersuchung der Analgesiequalität nach kinderchirurgischen Eingriffen. [s.l.]: [s.n.], 1998.

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4

Ricardo, Royder Yáñez, and Cruz Catata Teodora, eds. Mentisán, paracetamol o wira wira?: Jóvenes, salud e interculturalidad en los barrios mineros de Potosí. La Paz: PIEB, Programa de Investigación Estratégica en Bolivia, 2006.

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5

National Register of Foreign Collaborations (India) and India. Dept. of Scientific & Industrial Research., eds. Technology in Indian paracetamol industry: A status report prepared under the National Register of Foreign Collaborations. New Delhi: Govt. of India, Dept. of Scientific & Industrial Research, Ministry of Science and Technology, 1994.

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6

Dan, Micon. Paracetamol. Independently Published, 2018.

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7

Joe, Smith. Paracetamol. Independently Published, 2018.

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8

executive, Health and safety. Paracetamol. Health and Safety Executive (HSE), 1994.

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9

Paracetamol. Royal Society of Chemistry, 2002.

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10

Goody, Bob. War & Paracetamol. Burning Eye Books, 2021.

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11

Fermin, Solana. Paracetamol 500. Casa Editorial Hum, 2014.

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12

Mallet, Christophe, and Alain Eschalier. The rediscovery of paracetamol. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0004.

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The chapter describes experiments performed by Bernard B. Brodie and Julius Axelrod in an article published in 1948 and entitled ‘The fate of acetanilide in man’. This was an important breakthrough in the history of paracetamol (acetaminophen), which was synthesized in 1878 but only clinically used in 1955. We highlight how this article historically catalysed the rehabilitation (also called ‘the rediscovery’) of this popular over-the-counter painkiller. Demonstrating that paracetamol was the key active metabolite of acetanilide (an antipyretic/analgesic used at that time), and discarding the false idea that paracetamol causes methaemoglobinaemia, Brodie and Axelrod paved the way for this molecule to become nowadays the most sold analgesic worldwide, one which is still the subject of scientific publications.
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13

WOODHAMS. Standby Cpd: Paracetamol Overdose. Class Publishing, 2017.

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14

Levine, Michael. Management of acetaminophen (paracetamol) poisoning. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0318.

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Acetaminophen overdose remains common, and is one of the most frequent reasons for liver transplant in the United States. Toxicity results from the metabolism to a toxic metabolite, N-acetyl-para-benzoquinoneimine. This chapter begins with a brief discussion of the history and epidemiology of acetaminophen overdose, followed by a discussion on the pharmacokinetics and pharmacodynamics. The risk factors, clinical presentation, and treatment strategies presented.
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15

Bannwarth, Bernard, and Francis Berenbaum. Systemic analgesics (including paracetamol and opioids). Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0029.

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Apart from non-steroidal anti-inflammatory drugs (NSAIDs), there are only two categories of systemic analgesics, namely paracetamol (acetaminophen) and opioids, that are currently available worldwide for clinical use. Paracetamol is poorly effective in relieving pain and improving function in patients with symptomatic osteoarthritis (OA). Furthermore, its safety profile is less favourable than classically thought. In fact, there is evidence paracetamol acts as a weak inhibitor of the cyclooxygenase enzymes. Given that paracetamol poses a lower risk of severe adverse events than NSAIDs while being better tolerated than opioids, it is usually considered as the first-line systemic analgesic for OA. Commonly prescribed opioids are primarily agonists of the mu receptors, thereby producing similar desirable (analgesia) and untoward effects. Meta-analyses of short-term clinical trials showed that, on average, the modest clinical benefits of opioids did not outweigh the side effects in patients with knee or hip OA. Accordingly, most current guidelines support the use of opioids for selected OA patients only (e.g. patients who have not had an adequate response to other treatment modalities and are not candidates for total joint arthroplasty). In view of the limited efficacy and/or potential harms of available analgesics, particular attention was paid to novel painkillers, especially nerve growth factor (NGF) antagonists. Although these agents provided clinically meaningful improvements in pain and physical function in patients with hip or knee OA, they lead to severe side effects, including rapidly destructive arthropathies and neuropathies. Thus, if approved for marketing, NGF antagonists would be reserved for selected and well-defined patients with OA.
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16

Paracetamol (acetaminophen): A critical bibliographic review. London, UK: Taylor & Francis, 1996.

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17

Paracetamol (acetaminophen): A critical bibliographic review. 2nd ed. London: Taylor & Francis, 2001.

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18

Bozsak, Robert. Paracetamol - Anilinderivat und Analgetikum: Eine ausführliche Charakterisierung der chemischen Eigenschaften, medizinschen Wirkungsweisen und praktischen Anwendung von Paracetamol. GRIN Verlag GmbH, 2011.

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19

Group, Research, and The Acetaminophen Research Group. The 2000-2005 World Outlook for Acetaminophen (paracetamol). 2nd ed. Icon Group International, 2000.

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20

En Prozac is mijn paracetamol: Zestien en depressief. [Schiedam]: Scriptum, 2010.

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21

Parker, Philip M. The 2007-2012 World Outlook for Acetaminophen (paracetamol). ICON Group International, Inc., 2006.

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22

ICON, Group International Inc. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in Oceana. Icon Group International, 2001.

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23

ICON, Group International Inc. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in Europe. Icon Group International, 2001.

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24

Inc, ICON Group International. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in Asia. Icon Group International, 2001.

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25

Parker, Philip M. The 2007-2012 Outlook for Acetaminophen (paracetamol) in Japan. ICON Group International, Inc., 2006.

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26

Parker, Philip M. The 2007-2012 Outlook for Acetaminophen (paracetamol) in India. ICON Group International, Inc., 2006.

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27

Inc, ICON Group International. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in Africa. Icon Group International, 2001.

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28

Parker, Philip M. The 2007-2012 Outlook for Acetaminophen (paracetamol) in Greater China. ICON Group International, Inc., 2006.

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29

Inc, ICON Group International. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in Latin America. Icon Group International, 2001.

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30

Labelle, Garnet. Going Holiday with Pain : Guide to Prepare: Paracetamol Chronic Pain. Independently Published, 2021.

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31

ICON, Group International Inc. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in the Middle East. Icon Group International, 2001.

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32

Parker, Philip M. The 2007-2012 Outlook for Acetaminophen (paracetamol) in the United States. ICON Group International, Inc., 2006.

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33

Lauckner, Ira. Chronic Pain : Where the Body Meets the Brain: Paracetamol Chronic Pain. Independently Published, 2021.

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34

Hesters, Tameka. Chronic Pain Treatment : Some Remedies You Can Apply: Paracetamol Chronic Pain. Independently Published, 2021.

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35

Borman, Marilyn. Acetylcysteine: A Potent Medicine That Is Used to Treat Paracetamol Overdose. Independently Published, 2019.

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36

Funari, Jan. How to Treat Fibromyalgia : Fibromyalgia, Treatment and Care: Paracetamol Chronic Pain. Independently Published, 2021.

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37

Hübner, Dietmar Stephan. Zur Frage der Hepatotoxizität und Myokardtoxizität von Paracetamol: Eine elektronenmikroskopische, tierexperimentelle Untersuchung. 1988.

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38

Banerjee, Ashis, and Clara Oliver. Toxicology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198786870.003.0017.

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Toxicology questions frequently appear in the Intermediate FRCEM short-answer question (SAQ) paper and a general knowledge of poisoning and its associated management is required. This chapter covers the basic principles of poisoning and drug elimination. It also focuses on common toxidromes to aid diagnosis and their associated management. In addition, this chapter also provides detailed information and management for the commonest poisoning agents such as paracetamol, salicylates, tricyclic antidepressants, and carbon monoxide. Paracetamol overdose is one of the commonest presentations of poisoning to the emergency department, the treatment guidelines for which have recently changed. This chapter provides the basic pathophysiology of paracetamol toxicity and details the current management guidance.
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39

ICON, Group International Inc. The 2000-2005 Outlook for Acetaminophen (Paracetamol) in North America and the Caribbean. Icon Group International, 2001.

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40

Daniello, Delia. Postoperative Schmerzbekämpfung bei Kindern nach Tympanoplastiken: Klinische Doppelblindstudie mit Paracetamol, Piritramid und Tramadol. 1992.

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41

Beauharnois, Quintin. Cope with Chronic Pain : How Can I Adapt with Pain: Paracetamol Chronic Pain. Independently Published, 2021.

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42

Stacey, Victoria. Toxicology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199592777.003.0017.

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43

Main, Universität Frankfurt am, ed. Zur mutagenen Wirkung von Phenacetin und Paracetamol bei Salmonella typhimurium mit Aktivierungssystemen verschiedener Spezies. 1989.

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44

Vry, Dogad. Paracetamol: Medication for the Treatment of Fever, Pains, Migraine Attack, Menstrual Cramp and Joint Pains. Independently Published, 2018.

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45

Hegarty, Rob, and Fevronia Kiparissi. Drug-induced liver injury. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198759928.003.0058.

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The chapter on drug-induced liver injury discusses the definition, clinical manifestations, and then management of this frequently challenging to diagnose situation. It also covers in more detail the management of paracetamol overdose.
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46

Loeser, Winfried. Einfluss von Phenobarbital, Tetrachlorkohlenstoff, Phoron, Hyperthyreose und diabetischer Stoffwechsellage auf die biliäre Ausscheidung von Paracetamol bei Ratten. 1985.

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47

Hartung, Robert Friedrich. Analgetische und psychotrope Effekte von Paracetamol, Coffein und deren Kombination bei Ratten nach akuter und chronischer Applikation. 1995.

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48

Coloring, ParacetamolpIm. Coloring Book and Poster Collection: High on Paracetamol Polarized Light Photomicrograph of Thin Layer of Parace Fantasy. Independently Published, 2019.

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49

Coloring, ParacetamolVs. Coloring Book and Poster Collection: High on Paracetamol Polarized Light Photomicrograph of Thin Layer of Parace Fantasy. Independently Published, 2019.

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50

Sjøgren, Per, Frank Elsner, and Stein Kaasa. Non-opioid analgesics. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0096.

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Non-opioid analgesics encompass the non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol (acetaminophen). The NSAIDs include acetylsalicylic acid (ASA, aspirin), dipyrone (metamizole), and numerous other drugs in diverse classes. The NSAIDs have potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. In palliative medicine, they represent the first step of the World Health Organization’s analgesic ladder used for mild pain and they are an important supplement to opioids and adjuvant drugs at higher steps of the ladder. The disadvantages of non-opioid analgesics include a ceiling effect for pain relief and the risk of side effects. NSAIDs are also associated with an increased risk of adverse gastrointestinal, renal, and cardiovascular effects and hepatotoxicity can result from overdosing with paracetamol. This chapter describes the clinical pharmacology of NSAIDs, their classification, molecular mechanisms of action and adverse effects, as well as some recent developments aimed at designing effective anti-inflammatory agents with improved safety and tolerability profiles.
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