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Relevant bibliographies by topics / Parkinsonian disease

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Academic literature on the topic 'Parkinsonian disease'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Parkinsonian disease"

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Kościołek, Dawid, Michał Urbaś, Jakub Misiak, et al. "The effects that secondary parkinsonian syndromes have on health status." Journal of Education, Health and Sport 53 (January 18, 2024): 148–62. http://dx.doi.org/10.12775/jehs.2024.53.011.

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Introduction and aim of work: The parkinsonian syndrome is a component of Parkinson's disease. A thorough neurological examination can detect symptoms belonging to the parkinsonian syndrome. Diagnosis using the Queen Square Brain Bank criteria is based on the presence of bradykinesia along with one additional symptom in the patient. These include muscle rigidity or resting tremors at a frequency of 4-6 Hz, or postural disturbances that cannot be explained by visual, vestibular, cerebellar, or deep sensory disorders. The parkinsonian syndrome can occur in idiopathic Parkinson's disease, heredit

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Koros, Christos, Evangelia Stanitsa, Efthalia Angelopoulou, Sokratis G. Papageorgiou, and Leonidas Stefanis. "Cognitive Decline in Parkinsonism: From Clinical Phenotypes to the Genetic Background." Biomedicines 13, no. 7 (2025): 1624. https://doi.org/10.3390/biomedicines13071624.

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Background/Objectives: Cognitive impairment often occurs in various parkinsonian syndromes. The course of deficits in cognitive functions ranges from mild cognitive decline to severe deterioration. Affected cognitive domains are also variable. The genetic background of patients exhibiting parkinsonism with concomitant cognitive decline is still elusive. A significant part of current research in Parkinson’s disease and other parkinsonian syndromes is targeted towards the genetic aspects of these disorders. The aim of the present review was to summarize existing studies focusing on the investiga

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Mitchell, Susan L., and Kenneth Rockwood. "Defining Parkinsonism in the Canadian Study of Health and Aging." International Psychogeriatrics 13, S1 (2001): 107–13. http://dx.doi.org/10.1017/s1041610202008049.

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This study sought an operational definition of parkinsonism in elderly people (n = 2,914) who underwent a clinical examination in the Canadian Study of Health and Aging (CSHA). Parkinsonism was defined as having two of the following features: (1) bradykinesia of face or limbs, (2) resting tremor, (3) rigidity, and (4) abnormality of gait and posture. The association of parkinsonism with other parkinsonian-related features (prior diagnosis of Parkinson's disease, use of drugs with extrapyramidal side effects, and use of antiparkinsonian medications) and variables not expected to be related to p

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Mishima, Takayasu, Shinsuke Fujioka, Jiro Fukae, Junichi Yuasa-Kawada, and Yoshio Tsuboi. "Modeling Parkinson’s Disease and Atypical Parkinsonian Syndromes Using Induced Pluripotent Stem Cells." International Journal of Molecular Sciences 19, no. 12 (2018): 3870. http://dx.doi.org/10.3390/ijms19123870.

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Parkinson’s disease (PD) and atypical parkinsonian syndromes are age-dependent multifactorial neurodegenerative diseases, which are clinically characterized by bradykinesia, tremor, muscle rigidity and postural instability. Although these diseases share several common clinical phenotypes, their pathophysiological aspects vary among the disease categories. Extensive animal-based approaches, as well as postmortem studies, have provided important insights into the disease mechanisms and potential therapeutic targets. However, the exact pathological mechanisms triggering such diseases still remain

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Dr. M. Shyam Sundar and Dr. Hemalatha Rendocharakula. "Parkinsonism and Its Clinical Subtypes - An Observational Study in a Tertiary Care Hospital." IAR Journal of Medicine and Surgery Research 4, no. 5 (2023): 8–11. http://dx.doi.org/10.47310/iarjmsr.2023.v04i05.03.

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Background: The term Parkinsonism is defined by any combination of six specific motor features: tremors at rest, bradykinesia, rigidity, loss of postural reflexes, flexed posture, and the freezing phenomenon (where the feet are transiently “glued to the ground”). Not all six of these cardinal features need be present, but at least two should be before the diagnosis of Parkinsonism is made, with at least one of them being tremors at rest or bradykinesia. This study is a hospital based Observational study to understand the prevalence and rank order of subtypes of Parkinsonism. Material and Metho

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Ma, Yilong, Shichun Peng, Phoebe G. Spetsieris, Vesna Sossi, David Eidelberg, and Doris J. Doudet. "Abnormal Metabolic Brain Networks in a Nonhuman Primate Model of Parkinsonism." Journal of Cerebral Blood Flow & Metabolism 32, no. 4 (2011): 633–42. http://dx.doi.org/10.1038/jcbfm.2011.166.

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Parkinson's disease (PD) is associated with a characteristic regional metabolic covariance pattern that is modulated by treatment. To determine whether a homologous metabolic pattern is also present in nonhuman primate models of parkinsonism, 11 adult macaque monkeys with parkinsonism secondary to chronic systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 12 age-matched healthy animals were scanned with [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET). A subgroup comprising five parkinsonian and six control animals was used to identify a parkinsonism-related patte

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Hermida, Adriana P., A. Umair Janjua, Oliver M. Glass, et al. "A case of lithium-induced parkinsonism presenting with typical motor symptoms of Parkinson's disease in a bipolar patient." International Psychogeriatrics 28, no. 12 (2016): 2101–4. http://dx.doi.org/10.1017/s1041610216001101.

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ABSTRACTLithium is a mood stabilizer rarely associated with drug-induced parkinsonism (DIP). We present a case of an elderly woman with bipolar disorder who developed parkinsonian symptoms after chronic lithium administration despite therapeutic serum levels. Upon evaluation, classic parkinsonian signs of muscle rigidity, tremor, bradykinesia, freezing of gait, and cognitive decline were observed. Initially, she was diagnosed with Parkinson's disease (PD); however, DaTscan SPECT imaging clarified the diagnosis as DIP. As the daily lithium dosage was reduced, the patient's motor symptoms improv

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Ebmeier, K. P., S. A. Calder, J. R. Crawford, L. Stewart, R. H. B. Cochrane, and J. A. O. Besson. "Dementia in idiopathic Parkinson's disease: prevalence and relationship with symptoms and signs of Parkinsonism." Psychological Medicine 21, no. 1 (1991): 69–76. http://dx.doi.org/10.1017/s0033291700014665.

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SYNOPSISA whole population cohort of 157 patients with idiopathic Parkinsonism, most of whom had previously been clinically examined by Mutch (1986 a), were assessed to determine prevalence figures for dementia and examine the relationship between dementia, cognitive impairment and Parkinsonian signs. Dementia according to DSM-III-R criteria was diagnosed in 23·3% of all patients (95% confidence interval: 17·1 to 32·4%). Dementia and cognitive impairment were associated with overall measures of Parkinsonian impairment and rigidity, but not tremor, even after controlling for age, sex and educat

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Dal, Shoaib, and Scott Whyte. "035 Valproate-induced parkinsonism ‘an early warning’: case reports and review of literature." Journal of Neurology, Neurosurgery & Psychiatry 90, e7 (2019): A12.2—A12. http://dx.doi.org/10.1136/jnnp-2019-anzan.32.

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IntroductionWe describe two cases of valproate-induced parkinsonism, where the parkinsonian features develop after commencing valproate (VPA), in a time frame and manner well described by previous publications.1 In contrast to the published literature, that has short duration of follow-up, we have had a prolonged follow-up of these two cases, who initially improved on ceasing valproate, but then after a period progressed again, with the development of levodopa-responsive asymmetrical Parkinson’s disease.2Cases67 years old man, on VPA 500 mg twice a day for seizures since 2008, developed new re

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Rasaholiarison, Nomena Finiavana, Jemissair Glorien Lemahafaka, Lala Andriamasinavalona Rajaonarison, Manambina Ratsimandresy, Jenny Larissa Rakotomanana, and Alain Djacoba Tehindrazanarivelo. "Increasing Frequency of Parkinsonian Syndrome as a Reason for Admission to the Neurology Department of Befelatanana University Teaching Hospital, Madagascar." European Scientific Journal, ESJ 18, no. 17 (2022): 129. http://dx.doi.org/10.19044/esj.2022.v18n17p129.

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The number of parkinsonian syndrome patients in Africa is increasing. This study evaluated the increasing number of parkinsonian syndrome (PS) patients admitted to a hospital in Madagascar. A comparison was carried out between parkinsonism syndrome plus (PS+) and idiopathic Parkinson's Disease (PD) cases. Retrospectively, case records of patients with parkinsonism was reviewed between 2009 and 2018 in the Neurology Department of Befelatanana University Teaching Hospital, Antananarivo. Out of the 7343 patients seen in the unit over this period, 157 patients with PS were retained. It was found t

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Dissertations / Theses on the topic "Parkinsonian disease"

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Erickson-Davis, Cordelia R. "Neurofeedback training for Parkinsonian tremor and bradykinesia /." Connect to online version, 2006. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2006/153.pdf.

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Laverty, Vivian D. "Parkinsonian Personality: Psychometric Description of Intellectual-Motor Functioning." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc332144/.

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In an attempt to determine the normative levels in health attribution and emotional, intellectual, and neuromuscular functioning in the parkinsonian population, 31 diagnosed parkinsonian volunteers recruited from exercise classes and/or organizations were tested. Health attribution was measured by the Health Attribution Test (HAT), personality factors by the Clinical Analysis Questionnaire (CAQ), general intellectual level by the Peabody Picture Vocabulary Test- Revised (PPVT-R) and the Intellectual Processes subscale of the Luria-Nebraska Neuropsychological Battery (Luria- Intelligence), and

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Kozlosky, Kenneth M. "Perception of Parkinsonian speech ratings by self and listeners vs. acoustic measures /." Bowling Green, Ohio : Bowling Green State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1237512058.

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Chu, Chi-yuen Andrew. "A study on mitochondrial uncoupling protein 4 (UCP4) in Parkinsonian models." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39634449.

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Chu, Chi-yuen Andrew, and 朱志遠. "A study on mitochondrial uncoupling protein 4 (UCP4) in Parkinsonian models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634449.

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Lucarelli, Marisa Nicole. "Acoustic and Articulatory Kinematic Vowel Space in Parkinsonian Speech." University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1556877018282911.

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Kwok, Hon-hung Ken. "The role of UCP5 in mitochondrial dysfunction in Parkinsonian models." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508233.

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Manal, Kurt T. "Temporal assimilations during bi-manual movements in non-impaired and Parkinsonian individuals." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61329.

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When bi-lateral movements of differing difficulty are performed as rapidly as possible the "easier" of the two limbs slows down and is attracted to the temporal structure of the more difficult movement. Simultaneous movements are expected to be severely compromised in Parkinson's Disease (PD). The purpose of this study was to investigate whether Parkinsonians elicit temporal assimilations in the belief that an assimilatory response may facilitate simultaneous bi-lateral control in PD.<br>Temporal attractions were elicited by the non-impaired subjects during the bi-lateral task. The increased m

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Kwok, Hon-hung Ken, and 郭漢洪. "The role of UCP5 in mitochondrial dysfunction in Parkinsonian models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508233.

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Gravelin, Anna Christine. "Categorization of Silent Intervals in Parkinsonian Speech: A Study of Pause." Bowling Green State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1496839309918692.

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Books on the topic "Parkinsonian disease"

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B, Stern Matthew, and Koller William C. 1945-, eds. Parkinsonian syndromes. Marcel Dekker, 1993.

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Irene, Litvan, ed. Atypical Parkinsonian disorders. Humana Press, 2004.

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B, Stern Matthew, and Hurtig Howard I, eds. Parkinson's disease and Parkinsonian syndromes. Saunders, 1999.

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Schapira, Anthony H. V., Hartmann Andreas, and Yves Agid. Parkinsonian disorders in clinical practice. Wiley-Blackwell, 2009.

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V, Schapira Anthony H., Hartmann Andreas M. D, and Agid Yves, eds. Parkinsonian disorders in clinical practice. Wiley-Blackwell, 2009.

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P, Markey Sanford, ed. MPTP, aneurotoxin producing a Parkinsonian syndrome. Academic Press, 1986.

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Williams, Jean Balch. Parkinson's disease: studies in nonhuman primates: Annual update, March, 1992. A bibliography. Primate Information Center, Regional Primate Research Center, University of Washington, 1992.

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McLean, Miriam. Parkinson's disease: Studies in nonhuman primates : a bibliography : annual update, September, 1993. Primate Information Center, Regional Primate Research Center, University of Washington, 1993.

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Perkin, G. D. An illustrated pocketbook of Parkinson's disease and related disorders. Parthenon Pub. Group, 2003.

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1945-2005, Koller William C., and Melamed Eldad, eds. Parkinson's disease and related disorders. Elsevier, 2007.

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Book chapters on the topic "Parkinsonian disease"

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Hornykiewicz, O. "The discovery of dopamine deficiency in the parkinsonian brain." In Parkinson’s Disease and Related Disorders. Springer Vienna, 2006. http://dx.doi.org/10.1007/978-3-211-45295-0_3.

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Ballion, Bérangère, Nicolas Mallet, Catherine Moine, Mario Gustavo Murer, and Francois Gonon. "The Corticostriatal Transmission in Parkinsonian Animals: In Vivo Studies." In Cortico-Subcortical Dynamics in Parkinson¿s Disease. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-252-0_10.

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Arnulf, Isabelle, Valérie Cochen De Cock, Paul Reading, and Marie Vidailhet. "Sleep Disorders in Parkinson's Disease and Other Parkinsonian Syndromes." In Sleep Disorders in Neurology. John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781118777251.ch14.

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Gerlach, M., K. L. Double, M. B. H. Youdim, and P. Riederer. "Potential sources of increased iron in the substantia nigra of parkinsonian patients." In Parkinson’s Disease and Related Disorders. Springer Vienna, 2006. http://dx.doi.org/10.1007/978-3-211-45295-0_21.

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Peppard, R. F., and D. B. Calne. "Treatment of Parkinsonian Features in Neurological Disorders Other than Parkinson’s Disease." In Drugs for the Treatment of Parkinson’s Disease. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73899-9_22.

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Jindal, Parul, and Joseph Jankovic. "Botulinum Toxin Treatment in Parkinson’s Disease and Atypical Parkinsonian Disorders." In Botulinum Toxin Treatment in Clinical Medicine. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56038-0_3.

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Turpin, J. C., G. Dubois, A. Brice, et al. "Parkinsonian Symptomatology in a Patient with Type I (Adult) Gaucher’s Disease." In Lipid Storage Disorders. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1029-7_12.

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Kondo, T. "L-threo-DOPS—implications for pathophysiology of parkinsonian symptoms chronically treated with L-DOPA." In Parkinson’s Disease. From Clinical Aspects to Molecular Basis. Springer Vienna, 1991. http://dx.doi.org/10.1007/978-3-7091-9146-0_20.

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Fry, John, Gerald Sandler, and David Brooks. "Parkinsonism." In Disease Data Book. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4149-6_17.

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Lorenc-Koci, E., G. Schulze, M. Śmiałowska, et al. "Chronic Treatment with 1,2,3,4-Tetrahydroiso-Quinoline (TIQ), an Environmental and Endogenous Substance, Induces Parkinsonian like Muscle Rigidity in Young and Old Rats." In Neurotoxic Factors in Parkinson’s Disease and Related Disorders. Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1269-1_40.

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Conference papers on the topic "Parkinsonian disease"

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Mikael, Luana de Rezende, Coralia Gabrielle Vieira Silveira, Camilla Duarte Ribeiro, et al. "Fahr’s syndrome as a differential diagnosis amid parkinsonian syndromes: a case report." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.465.

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Context: Parkinsonian syndromes are routinely identified by neurologists. However, the differential diagnosis among probable etiologies can be challenging and complex. In Fahr’s syndrome, calcifications of the basal ganglia secondary to disorders of calcium metabolism are observed. A possible clinical presentation associated with this entity is the presence of a parkinsonian syndrome. Case report: A 54-years-old female patient presented with a progressive tremor in the right upper and lower limbs associated with bradykinesia. Seizures were observed during the course of the disease. After exten

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Zanghi, Nicholas, Taylor Good, Shivam Patel, and Francois Gould. "Identifying Chewing Alterations in a Parkinsonian Model." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. http://dx.doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.14_2024.

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Patients suffering from Parkinson’s Disease will typically experience a range of motor and nonmotor symptoms. Characteristic signs of Parkinson’s include pill-rolling tremor, stooped posture, and shuffling gate. Patients with this disease can also develop oropharyngeal dysfunction, which can disable patients from meeting their physiologic needs. Understanding this disability and the changes in mastication kinematics can lead to potential future treatment. Our study induced Parkinson’s in rats with rotenone injections. Their jaw kinematics were identified through fluoroscopy of radio-opaque bea

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Shah, Vrutangkumar V., Sachin Goyal, and Harish Palanthandalam-Madapusi. "A Biomechanical Approach to Diagnosis and Monitoring of Parkinson’s Disease." In ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/detc2015-46781.

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Parkinson’s disease is an idiopathic and degenerative disorder of the central nervous system. Among the symptoms, the tremor at rest is one of the prominent symptoms. The challenge however is that there are no definitive diagnostic test that can confirm the presence or severity of Parkinson’s disease. This is a serious handicap especially since the drugs usually prescribed to control these symptoms have serious side effects and their dosages have to be tuned extensively. Also, the exact origin of tremor is unknown. There have been recent efforts [19] to understand the mechanism behind the Park

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Haman, Michael J., and Christopher R. Kelley. "Capturing Parkinson’s Disease Tremor and Vigor With a Single Disease Parameter." In ASME 2023 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/detc2023-117228.

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Abstract Parkinson’s disease (PD) is a progressive neurological disorder that significantly affects movement. It is caused by a loss of dopamine-producing cells in the basal ganglia, a group of brain structures that play a key role in motor control. Two of the most pronounced motor symptoms in PD are tremor and reduced movement vigor, known as bradykinesia. This research hypothesizes that a single physiological mechanism can produce both tremor and movement inhibition in PD through its influence on system-level controller parameters. This paper explores this hypothesis with a model that uses a

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Mei, Jie, Cécilia Tremblay, Nikola Stikov, Christian Desrosiers, and Johannes Frasnelli. "Differentiation of Parkinson’s disease and non-Parkinsonian olfactory dysfunction with structural MRI data." In Computer-Aided Diagnosis, edited by Karen Drukker and Maciej A. Mazurowski. SPIE, 2021. http://dx.doi.org/10.1117/12.2581233.

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Maffia, Marta, Rosa De Micco, Alessandro Tessitore, and Anna De Meo. "Acoustic characteristics of Italian Parkinsonian speech: a study on early-stage patients." In 11th International Conference of Experimental Linguistics. ExLing Society, 2020. http://dx.doi.org/10.36505/exling-2020/11/0029/000444.

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Parkinson’s Disease (PD) is a neurological illness which also has effects on speech production, resulting in segmental and suprasegmental abnormalities. The aim of the current study is to test the validity of two acoustic parameters - %V and VtoV - for the detection of rhythmical variation in early-stage PD speech, in comparison to healthy speech. 40 Italian native speakers were enrolled in the research, 20 early-stage PD subjects and 20 neurologically healthy and matched controls, and a corpus of read speech was collected. The results of voice analysis confirmed an alteration of vocalic durat

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Selman, Selman, Hala Madhi, and Kaiser NeamaMadlum. "Anti-parkinsonian Activity of Borago Officinalis Ethanolic Extract in Rotenone- Induced Rat Model of Parkinson’s Disease." In 5th International Conference on Biomedical and Health Sciences. Cihan University-Erbil, 2024. http://dx.doi.org/10.24086/biohs2024/paper.1288.

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Abstract—Background: Parkinson disease (PD) was one of the most prevalent slow-moving, age-related neurodegenerative diseases, which is characterized by the death of dopaminergic neurons in the substantia nigra (SN). Bradykinesia, stiffness, postural instability, akinesia, and tremor are some clinical motor signs of PD.This study aims to investigate the antioxidant and anti- inflammatory effects of B.Officinalis extract. Materials and Methods:The 70 healthy male Albino rats used in this experiment study,the first group was designated as the healthy control group and other rats were orally admi

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Palhang, Meejan, N. Charles, and Francois Gould. "Swallowing Disrupts Tongue-Jaw Coordination During Chewing in a Rat Model of Parkinson's Disease." In 27th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2023. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.127_2023.

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The primary motor symptoms of Parkinson’s disease, including bradykinesia, rigidity, and tremor, are associated with difficulties regulating transitions between motor behaviors due to basal ganglia dysfunction. Chewing and swallowing, which are disordered in most patients with Parkinson’s disease, are two complex motor behaviors which overlap in time and share some neuromuscular components. The objective of this study is to identify how Parkinson’s disease affects the coordination of chewing and swallowing. We hypothesize that as a result of impaired regulation of shift between motor patterns,

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Doughty, Timothy, Jordan Heintz, and Melissa Ishii. "Reducing Parkinsonian Hand Tremor With a Novel Dynamic Eating Utensil." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-65282.

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The work presented here details the modeling, fabrication, testing, and analysis of a dynamic eating utensil designed to reduce hand tremors in subjects with Parkinson’s disease. Most of the current work addressing this problem has been invasive, using medicine or electrical brain stimulation for example. Here, an analysis is presented on the nature of the tremor. This is then used to develop a multi degree-of-freedom analytic model for the forearm/wrist/utensil system. Experiments were performed to identify model form and parameters and theory is presented which allowed for optimized system d

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Doughty, Timothy A., and Nicholas Bankus. "Mechanical Modeling and Design for Reduction of Parkinsonian Hand Tremor." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-39073.

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Most of the active research in reducing Parkinsonian tremor involves invasive surgeries or medical treatment. In this paper hand tremors associated with Parkinson’s Disease (PD) are studied and passive vibration control methods are developed and tested. Patients with PD are surveyed regarding difficulties with hand tremor during the act of eating. The result leads to design criteria for an enhanced eating utensil and the establishment of meaningful testing methods for measuring hand tremor. Tremor data collected from several PD patients provides insight into the nature of the motion and allows

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Reports on the topic "Parkinsonian disease"

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Zhang, Yu, Chaoliang Sun, Hengxi Xu, et al. Connectivity-Based Subtyping of De Novo Parkinson Disease: Biomarkers, Medication Effects and Longitudinal Progression. Progress in Neurobiology, 2024. http://dx.doi.org/10.60124/j.pneuro.2024.10.04.

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Parkinson's disease (PD) is characterized by divergent clinical symptoms and prognosis, suggesting the presence of distinct subtypes. Identifying these subtypes is crucial for understanding the underlying pathophysiology, predicting disease progression, and developing personalized treatments. In this study, we propose a connectivity-based subtyping approach, which measures each patient's deviation from the reference structural covariance networks established in healthy controls. Using data from the Parkinson's Progression Markers Initiative, we identified two distinct subtypes of de novo PD pa

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SPECT Dopamine Transporters, Consensus QIBA Profile. Chair John Dickson and John Seibyl. Radiological Society of North America (RSNA)/Quantitative Imaging Biomarkers Alliance (QIBA), 2019. https://doi.org/10.1148/qiba/20191015.

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Parkinsonism is a major health problem. Distinguishing neurodegenerative causes of parkinsonism from non-degenerative movement disorders that can mimic Parkinson’s disease (PD) has important implications for prognosis and clinical management. The goal of this QIBA Profile is to optimize the performance of Iodine-123 (123I) ioflupane single photon emission computed tomography (SPECT) for quantifying the concentration of regional cerebral dopamine transporters (DaT) in patients with movement disorders. The Claim (Section 2): This profile claims that conformance with its specifications will provi

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