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Journal articles on the topic 'PEG-PCL'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Gou, MaLing, ChangYang Gong, Juan Zhang, et al. "Polymeric matrix for drug delivery: Honokiol-loaded PCL-PEG-PCL nanoparticles in PEG-PCL-PEG thermosensitive hydrogel." Journal of Biomedical Materials Research Part A 9999A (2009): NA. http://dx.doi.org/10.1002/jbm.a.32546.

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2

Hwang, Min Ji, Ju Myung Suh, You Han Bae, Sung Wan Kim, and Byeongmoon Jeong. "Caprolactonic Poloxamer Analog: PEG-PCL-PEG." Biomacromolecules 6, no. 2 (2005): 885–90. http://dx.doi.org/10.1021/bm049347a.

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3

Alipour, Mahdieh, Javad Ashrafihelan, Roya Salehi, et al. "In vivo evaluation of biocompatibility and immune modulation potential of poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone)-gelatin hydrogels enriched with nano-hydroxyapatite in the model of mouse." Journal of Biomaterials Applications 35, no. 10 (2021): 1253–63. http://dx.doi.org/10.1177/0885328221998525.

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Biocompatible, biodegradable, and injectable hydrogels are a novel and promising approach for bone regeneration. In this study, poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone) (PCL-PEG-PCL), PCL-PEG-PCL-gelatin (Gel), PCL-PEG-PCL-Gel/nano-hydroxyapatite (nHA) injectable hydrogels were synthesized and evaluated in a mouse model of subcutaneous transplantation after 14 days. PCL-PEG-PCL-Gel and PCL-PEG-PCL-Gel/nHA hydrogels were fabricated with in situ precipitation method. Structure, intermolecular interaction, and the reaction between the PCL-PEG-PCL, Gel, and nHA were evaluated us

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4

Manjili, Hamidreza Kheiri, Ali Sharafi, Hossein Danafar, Mirjamal Hosseini, Ali Ramazani, and Mohammad Hossein Ghasemi. "Poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone) (PCL–PEG–PCL) nanoparticles: a valuable and efficient system for in vitro and in vivo delivery of curcumin." RSC Advances 6, no. 17 (2016): 14403–15. http://dx.doi.org/10.1039/c5ra24942b.

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5

Wang, Jian Hua, Shuen Liang, Yan Yan Wang, Chun Rong Tian, and Xiu Li Zhao. "Mechanical and Dynamic Mechanical Properties of Degradable Polyurethane Foams with PEG/PCL Mixed Soft Segments." Advanced Materials Research 183-185 (January 2011): 1611–15. http://dx.doi.org/10.4028/www.scientific.net/amr.183-185.1611.

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Polyurethane (PU) with mixed poly(ethylene glycol) / poly(ε-caprolactone) (PEG/PCL) soft segments is a representatively kind of degradable polyurethane material. Polyurethane foams (PUF) with mixed PEG/PCL soft segments were synthesized by using one pot method, and their mechanical and dynamic mechanical properties were investigated. Influences of PEG/PCL weight ratio and molecular weight of soft segments on PUF's mechanical and dynamic mechanical properties were studied. The results showed that: with increasing content of PCL, PUF's tensile strength, elongation at break, stress at certain ten

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6

Du, Xu, Qin Wang, Chuan Dong Wang, and Yang Liu. "Synthesis and Self-Assembly Study of Biodegradable Amphiphilic Triblock Copolymers with PEG Block." Advanced Materials Research 998-999 (July 2014): 95–98. http://dx.doi.org/10.4028/www.scientific.net/amr.998-999.95.

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Three biodegradable amphiphilic triblock copolymers: polylactide-poly (ethylene glycol)-polylactide (PLA-PEG-PLA), poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) (PCL-PEG-PCL) and poly (lactide-glycolide)-poly (ethylene glycol)-poly (lactide-glycolide) (PLGA-PEG-PLGA) were synthesized. Their chemical structures were characterized. In aqueous solution, their self-assembly and degradation were studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Spherical micelles were formed in aqueous solution via self-assembly of the amphiphilic triblock co

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7

Zhou, Yanyan, Lei Li, Wei Chen та ін. "A twin-tailed tadpole-shaped amphiphilic copolymer of poly(ethylene glycol) and cyclic poly(ε-caprolactone): synthesis, self-assembly and biomedical applications". Polymer Chemistry 9, № 33 (2018): 4343–53. http://dx.doi.org/10.1039/c8py00022k.

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8

Lee, Hyun Jung, and Byeongmoon Jeong. "ROS‐Sensitive Degradable PEG–PCL–PEG Micellar Thermogel." Small 16, no. 12 (2020): 1903045. http://dx.doi.org/10.1002/smll.201903045.

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9

Yu, Lin, Hongtao Hu, Lin Chen, et al. "Comparative studies of thermogels in preventing post-operative adhesions and corresponding mechanisms." Biomater. Sci. 2, no. 8 (2014): 1100–1109. http://dx.doi.org/10.1039/c4bm00029c.

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10

Lee, Jin Woo, and Kuk Ro Yoon. "Fabrication and characterization of block copolymer (PCL/PCL-PEG) nanofibers binding with collagen by electrospun." Analytical Science and Technology 27, no. 5 (2014): 228–33. http://dx.doi.org/10.5806/ast.2014.27.5.228.

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11

Hu, Yong, Yin Ding, Yuan Li, Xiqun Jiang, Changzheng Yang та Yonghua Yang. "Physical Stability and Lyophilization of Poly(ε-caprolactone)-b-Poly(ethyleneglycol)-b-Poly(ε-caprolactone) Micelles". Journal of Nanoscience and Nanotechnology 6, № 9 (2006): 3032–39. http://dx.doi.org/10.1166/jnn.2006.432.

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The stability and lyophilization of core–shell PCL-PEG-PCL micelles were investigated by fluorescence spectra, DLS, DSC, WAXD, and FT-IR. The prepared micelles were not stable when they were stored in aqueous dispersion under different condition. Their size increased in the first 20 days and decreased gradually when the storage period was extended. Lyophilization experiment showed that the cryoprotective agent (glucose) was an essential additive to protect the micelles from aggregating during the lyophilization process. After lyophilizing and re-dispersion, the PCL-PEG-PCL micelles became larg

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12

Fu, Na, Jinfeng Liao, Shiyu Lin, et al. "PCL-PEG-PCL film promotes cartilage regeneration in vivo." Cell Proliferation 49, no. 6 (2016): 729–39. http://dx.doi.org/10.1111/cpr.12295.

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13

Blackwell, Catherine, Karolina Haernvall, Georg Guebitz, Michael Groombridge, Denis Gonzales та Ezat Khosravi. "Enzymatic Degradation of Star Poly(ε-Caprolactone) with Different Central Units". Polymers 10, № 11 (2018): 1266. http://dx.doi.org/10.3390/polym10111266.

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Four-arm star poly(ε-caprolactone) with a central poly(ethylene glycol) PEG unit bridged with 2,2-bis(methyl) propionic acid, (PCL)2-b-PEG-b-(PCL)2, and six-arm star PCL homopolymer with a central dipentaerythritol units were hydrolysed using a lipase from Pseudomonas cepacia and the Thermobifida cellulosilytica cutinase Thc_Cut1. For comparative analysis, Y-shaped copolymers containing methylated PEG bridged with bisMPA, MePEG-(PCL)2, and linear triblock copolymers PCL-b-PEG-b-PCL were also subjected to enzymatic hydrolysis. The hydrophilic nature of the polymers was determined using contact

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14

Sun, Tao, Xiaomin Shuai, Kaixin Ren, et al. "Amphiphilic Block Copolymer PCL-PEG-PCL as Stationary Phase for Capillary Gas Chromatographic Separations." Molecules 24, no. 17 (2019): 3158. http://dx.doi.org/10.3390/molecules24173158.

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This work presents the first example of utilization of amphiphilic block copolymer PCL-PEG-PCL as a stationary phase for capillary gas chromatographic (GC) separations. The PCL-PEG-PCL capillary column fabricated by static coating provides a high column efficiency of 3951 plates/m for n-dodecane at 120 °C. McReynolds constants and Abraham system constants were also determined in order to evaluate the polarity and possible molecular interactions of the PCL-PEG-PCL stationary phase. Its selectivity and resolving capability were investigated by using a complex mixture covering analytes of diverse

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15

Chen, Y., Y. X. Zhang, Z. F. Wu та ін. "Biodegradable poly(ethylene glycol)–poly(ε-carprolactone) polymeric micelles with different tailored topological amphiphilies for doxorubicin (DOX) drug delivery". RSC Advances 6, № 63 (2016): 58160–72. http://dx.doi.org/10.1039/c6ra06040d.

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16

Visan, Anita Ioana, Gianina Popescu-Pelin, Oana Gherasim, et al. "Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions." Polymers 12, no. 3 (2020): 717. http://dx.doi.org/10.3390/polym12030717.

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Our study focused on the long-term degradation under simulated conditions of coatings based on different compositions of polycaprolactone-polyethylene glycol blends (PCL-blend-PEG), fabricated for titanium implants by a dip-coating technique. The degradation behavior of polymeric coatings was evaluated by polymer mass loss measurements of the PCL-blend-PEG during immersion in SBF up to 16 weeks and correlated with those yielded from electrochemical experiments. The results are thoroughly supported by extensive compositional and surface analyses (FTIR, GIXRD, SEM, and wettability investigations

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17

Dal Poggetto, Giovanni, Salvatore Simone Troise, Claudia Conte та ін. "Nanoparticles decorated with folate based on a site-selective αCD-rotaxanated PEG-b-PCL copolymer for targeted cancer therapy". Polymer Chemistry 11, № 23 (2020): 3892–903. http://dx.doi.org/10.1039/d0py00158a.

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18

Nasongkla, Norased, Patoomratana Tuchinda, Bamroong Munyoo, and Komgrit Eawsakul. "Preparation and Characterization of MUC-30-Loaded Polymeric Micelles against MCF-7 Cell Lines Using Molecular Docking Methods and In Vitro Study." Evidence-Based Complementary and Alternative Medicine 2021 (May 28, 2021): 1–9. http://dx.doi.org/10.1155/2021/5597681.

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MUC-30 is a hydrophobic compound which is active against the MCF-7 cancer cell line. In this study, MUC-30 was loaded in polymeric micelles to improve the water solubility and release rate. For prolonged MUC-30 release, MUC-30 was encapsulated in polymeric micelles using PEG-b-PLA and PEG-b-PCL as materials. Micelles prepared with 1 : 9 w per w ratios by film hydration achieved the highest entrapment efficiency (EE%). The EE% of MUC-30-loaded PEG-b-PCL micelles was approximately 30% greater than that of PEG-b-PLA micelles, due to the different H-bond formations between MUC-30 and the polymer m

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19

Wang, Jian Hua, Shuen Liang, Chun Rong Tian, Xiu Li Zhao, and Xiao Yan Lin. "Study on Degradable Polyurethane Foams with Mixed PEG/PCL and PLA/PCL Soft Segments." Advanced Materials Research 518-523 (May 2012): 821–27. http://dx.doi.org/10.4028/www.scientific.net/amr.518-523.821.

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Through inclusion of different polymer chains with different properties into polyurethane matrix, such as poly(ethylene glycol) (PEG), poly(ε-caprolactone) (PCL), poly(lactic acid) (PLA), or poly(tetramethylene oxide) (PTMG), degradable polyurethane foams (PUFs) with different molecular structure were prepared. Influences of molecular structure on PUF materials’ performance were studied systematically. When PEG, PCL, PLA, and PTMG serve as soft segment, PUFs’ storage modulus and glass transition temperature (Tg) of PUFs decrease with following order: PLA>PCL>PEG>PTMG (flexibility of P

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20

Mu, Jianning, Xiaoyu Meng, Li Chen, et al. "Highly stable and biocompatible W18O49@PEG-PCL hybrid nanospheres combining CT imaging and cancer photothermal therapy." RSC Advances 7, no. 18 (2017): 10692–99. http://dx.doi.org/10.1039/c6ra28161c.

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21

Park, Changhee, Jihye Yoo, Donghyun Lee, Seok-young Jang, Soonmin Kwon, and Heebeom Koo. "Chlorin e6-Loaded PEG-PCL Nanoemulsion for Photodynamic Therapy and In Vivo Drug Delivery." International Journal of Molecular Sciences 20, no. 16 (2019): 3958. http://dx.doi.org/10.3390/ijms20163958.

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We fabricated poly (ethylene glycol)-block-polycaprolactone (PEG-b-PCL) nanoemulsion for drug delivery and photodynamic therapy. PEG-b-PCL effectively stabilized the interface between water and soybean oil, and the resulting nanoemulsion was about 220.3 nm in diameter with spherical shape. For photodynamic therapy (PDT), chlorin e6 (Ce6) was loaded into the nanoemulsion as a photosensitizer (PS). These chlorin e6-loaded PEG-PCL nanoemulsions (Ce6-PCL-NEs) showed efficient cellular uptake and, upon laser irradiation, generated singlet oxygen to kill tumor cells. Particularly, Ce6-PCL-NEs showed

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22

GONG, C., S. SHI, P. DONG, et al. "Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel." International Journal of Pharmaceutics 365, no. 1-2 (2009): 89–99. http://dx.doi.org/10.1016/j.ijpharm.2008.08.027.

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23

Yin, Guangzhong, Guangxin Chen, Zheng Zhou, and Qifang Li. "Modification of PEG-b-PCL block copolymer with high melting temperature by the enhancement of POSS crystal and ordered phase structure." RSC Advances 5, no. 42 (2015): 33356–63. http://dx.doi.org/10.1039/c5ra01971k.

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Alkyne-functionalized polyhedral oligomeric silsesquioxane was successfully prepared and further used to modify PEG-b-PCL via click chemistry, resulting in a successful synthesis of POSS grafted PEG-b-PCL.

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24

Wang, Siyuan, Xiaobo Feng, Ping Liu, Youxiu Wei, and Baojun Xiao. "Blending of PLGA-PEG-PLGA for Improving the Erosion and Drug Release Profile of PCL Microspheres." Current Pharmaceutical Biotechnology 21, no. 11 (2020): 1079–87. http://dx.doi.org/10.2174/1389201021666200101104116.

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Background: PCL has a long history as an industrialized biomaterial for preparing microspheres, but its hydrophobic property and slow degradation rate often cause drug degeneration, quite slow drug release rate and undesirable tri-phasic release profile. Materials and Methods: In this study, we used the blending material of PLGA-PEG-PLGA and PCL to prepare microspheres. The microspheres degradation and drug release behaviors were evaluated through their molecular weight reduction rate, mass loss rate, morphology erosion and drug release profile. The hydrophilic PLGA-PEG-PLGA is expected to imp

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25

Kanazawa, Takanori, Takumi Kurano, Hisako Ibaraki, Yuuki Takashima, Toyofumi Suzuki, and Yasuo Seta. "Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles." Pharmaceutics 11, no. 9 (2019): 478. http://dx.doi.org/10.3390/pharmaceutics11090478.

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We previously reported that siRNA delivery to the brain is improved by the nose-to-brain delivery route and by conjugation with polyethylene glycol-polycaprolactone (PEG-PCL) polymer micelles and the cell-penetrating peptide, Tat (PEG-PCL-Tat). In this study, we evaluated the nose-to-brain delivery of siRNA targeting TNF-α (siTNF-α) conjugated with PEG-PCL-Tat to investigate its therapeutic effects on a transient middle cerebral artery occlusion (t-MCAO) rat model of cerebral ischemia-reperfusion injury. Intranasal treatment was provided 30 min after infarction induced via suturing. Two hours

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26

Yu, Bing, Qingye Meng, Hao Hu, Tao Xu, Youqing Shen, and Hailin Cong. "Construction of Dimeric Drug-Loaded Polymeric Micelles with High Loading Efficiency for Cancer Therapy." International Journal of Molecular Sciences 20, no. 8 (2019): 1961. http://dx.doi.org/10.3390/ijms20081961.

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Polymeric micelles (PMs) have been applied widely to transport hydrophobic drugs to tumor sites for cancer treatment. However, the low load efficiency of the drug in the PMs significantly reduces the therapeutic efficiency. We report here that disulfide-linked camptothecin (CPT) as a kind of dimeric drug can be effectively embedded in the core of poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone) (PCL–PEG–PCL) PMs for improving drug-loading efficiency, and PEG can be used as a hydrophilic shell. Moreover, the dimeric CPT-loaded PCL–PEG–PCL PMs exhibited excellent solubility in pho

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27

Jafari, Amin, Lingyue Yan, Mohamed Alaa Mohamed, Yun Wu та Chong Cheng. "Well-Defined Diblock Poly(ethylene glycol)-b-Poly(ε-caprolactone)-Based Polymer-Drug Conjugate Micelles for pH-Responsive Delivery of Doxorubicin". Materials 13, № 7 (2020): 1510. http://dx.doi.org/10.3390/ma13071510.

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Nanoparticles have emerged as versatile carriers for various therapeutics and can potentially treat a wide range of diseases in an accurate and disease-specific manner. Polymeric biomaterials have gained tremendous attention over the past decades, owing to their tunable structure and properties. Aliphatic polyesters have appealing attributes, including biodegradability, non-toxicity, and the ability to incorporate functional groups within the polymer backbone. Such distinctive properties have rendered them as a class of highly promising biomaterials for various biomedical applications. In this

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28

Miao, Ke, Huanhuan Liu, and Youliang Zhao. "Thermo, pH and reduction responsive coaggregates comprising AB2C2 star terpolymers for multi-triggered release of doxorubicin." Polym. Chem. 5, no. 10 (2014): 3335–45. http://dx.doi.org/10.1039/c3py01767b.

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Novel disulfide-linked PEG(PCL)<sub>2</sub>(PNIPAM)<sub>2</sub> and PEG(PCL)<sub>2</sub>(PAA)<sub>2</sub> star terpolymers were synthesized and coassembled into mixed micelles or vesicles for multi-triggered drug release.

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29

Hsu, Chih Yueh, Chin Chung Wei, and Cho-Pei Jiang. "Tribological Study of PCL-PEG-PCL Polymer on SiN_xH_y Base." Key Engineering Materials 642 (April 2015): 264–69. http://dx.doi.org/10.4028/www.scientific.net/kem.642.264.

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Tribological behaviour of polymer and hard coating films is complicated with bio-lubricant. Contacting and kinematic conditions of a knee joint when a person in running was simulated in the study. Substrates of specimens are Ti6Al4V and 316LVM stainless steel. Two kinds of polymer films, PCL-PEG-PCL and mPEG-PCL-mPEG, were used to simulate the tissue of cartilage. The silicon nitride film, SiNxHy prepared by PECVD, was used as a protecting film, and it’s thickness about 1000 nm under the polymer film. The testing device was developed, upper specimen is rotated reversely and the lower one is mo

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30

Steinman, Noam Y., Noam Y. Bentolila, and Abraham J. Domb. "Effect of Molecular Weight on Gelling and Viscoelastic Properties of Poly(caprolactone)–b-Poly(ethylene glycol)–b-Poly(caprolactone) (PCL–PEG–PCL) Hydrogels." Polymers 12, no. 10 (2020): 2372. http://dx.doi.org/10.3390/polym12102372.

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Hydrogels based on poly(caprolactone)–b-poly(ethylene glycol)–b-poly(caprolactone) (PCL–PEG–PCL) have been evaluated extensively as potential injectable fillers or depots for controlled release of drugs. Common drawbacks of these copolymer systems include instability of aqueous solutions and low mechanical strength of gels, issues which are commonly overcome by adding pendant groups to the end of the copolymer chains. Here, a systematic study of the effects of increasing polymer molecular weight (MW) is presented, utilizing PEG blocks of MW 2, 4 or 8 kDa. Triblock copolymers were prepared by t

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31

Vozzi, Federico, Tiziana Nardo, Ilenia Guerrazzi, et al. "Integration of Biomechanical and Biological Characterization in the Development of Porous Poly(caprolactone)-Based Membranes for Abdominal Wall Hernia Treatment." International Journal of Polymer Science 2018 (December 9, 2018): 1–15. http://dx.doi.org/10.1155/2018/2450176.

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Aims. Synthetic meshes are the long-standing choice for the clinical treatment of abdominal wall hernias: the associated long-term complications have stimulated the development of a new generation of bioresorbable prostheses. In this work, polycaprolactone (PCL) porous membranes prepared by solvent casting/porogen leaching of PCL/poly(ethylene glycol) (PEG) blends with different compositions (different PCL/PEG weight ratios and PEG molecular weights) were investigated to be applied in the field. An optimal porous membrane structure was selected based on the evaluation of physicochemical, biome

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32

Ma, Rujiang, Xiaocheng Sun, Xiaojun Liu, Yingli An, and Linqi Shi. "Complex Micelles with Glucose-Responsive Shells for Self-Regulated Release of Glibenclamide." Australian Journal of Chemistry 67, no. 1 (2014): 127. http://dx.doi.org/10.1071/ch13334.

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Complex micelles with a hydrophobic poly(ϵ-caprolactone) (PCL) core and a mixed P(Asp-co-AspPBA)/PEG shell were prepared through co-assembly of two block copolymers PCL-b- P(Asp-co-AspPBA) and PEG-b-PCL in basic aqueous solutions. The P(Asp-co-AspPBA) chains (Asp = aspartic acid; AspPBA = aspartamidophenylboronic acid) collapsed and formed a shell layer around the PCL core at neutral pH while the soluble PEG chains stabilised the micelles. The collapsed P(Asp-co-AspPBA) polymer becomes soluble under higher glucose concentration and collapses onto the PCL core reversibly at lower glucose concen

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33

Shakibaie, Mehdi, Marieh Ghafari Rahbar, Fatemeh Tabandeh, et al. "Development of PCL-PEG nanofibrous mats as alternative carriers for recombinant Chinese hamster ovary cells." Journal of Polymer Engineering 32, no. 6-7 (2012): 453–61. http://dx.doi.org/10.1515/polyeng-2011-0114.

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Abstract In this study, six polyblended nanofiber mats, composed of poly ε-caprolactone (PCL)-polyethylene glycol (PEG) mixed at different proportions in an electrospinning solution were fabricated, and then utilized alongside commercial polyester microcarriers for the mass cultivation of recombinant Chinese hamster ovary (rCHO) cells. The SEM micrographs showed that the rCHO cells were attached to the nanofiber mats with significant differences in their affinities, which can be related to the chemical structure and hydrophilicity of the nanofiber mats. The cell densities of the rCHO cells gro

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34

Gao, Xiang, Bing Kan, MaLing Gou, et al. "Preparation of Anti-CD40 Antibody Modified Magnetic PCL-PEG-PCL Microspheres." Journal of Biomedical Nanotechnology 7, no. 2 (2011): 285–91. http://dx.doi.org/10.1166/jbn.2011.1280.

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35

Pazarçeviren, Engin, Özge Erdemli, Dilek Keskin, and Ayşen Tezcaner. "Clinoptilolite/PCL–PEG–PCL composite scaffolds for bone tissue engineering applications." Journal of Biomaterials Applications 31, no. 8 (2016): 1148–68. http://dx.doi.org/10.1177/0885328216680152.

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36

Cai, Yuee, Shengpeng Wang, Minghui Wu, et al. "PCL–F68–PCL/PLGA–PEG–PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer." RSC Advances 6, no. 42 (2016): 35318–27. http://dx.doi.org/10.1039/c5ra27648a.

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37

Türkkan, Sibel, A. Engin Pazarçeviren, Dilek Keskin, Nesrin E. Machin, Özgür Duygulu, and Ayşen Tezcaner. "Nanosized CaP-silk fibroin-PCL-PEG-PCL/PCL based bilayer membranes for guided bone regeneration." Materials Science and Engineering: C 80 (November 2017): 484–93. http://dx.doi.org/10.1016/j.msec.2017.06.016.

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38

Lim, Hyunju, Ji-Yeon Shin, Deuk Yong Lee, Bae-Yeon Kim, and Yo-Seung Song. "Drug Delivery Behavior of PCL and PCL/PEG Microcapsules Prepared by High-speed Agitator and Syringe Pump." Polymer Korea 44, no. 4 (2020): 487–94. http://dx.doi.org/10.7317/pk.2020.44.4.487.

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39

Dinçer, Sevil, Mustafa Türk, Ayşe Karagöz, and Gürhan Uzunalan. "Potentialc-mycAntisense Oligonucleotide Carriers: PCl/PEG/PEI and PLL/PEG/PEI." Artificial Cells, Blood Substitutes, and Biotechnology 39, no. 3 (2010): 143–54. http://dx.doi.org/10.3109/10731199.2010.506852.

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40

Güney, Aysun, Christina Gardiner, Andrew McCormack, Jos Malda, and Dirk Grijpma. "Thermoplastic PCL-b-PEG-b-PCL and HDI Polyurethanes for Extrusion-Based 3D-Printing of Tough Hydrogels." Bioengineering 5, no. 4 (2018): 99. http://dx.doi.org/10.3390/bioengineering5040099.

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Novel tough hydrogel materials are required for 3D-printing applications. Here, a series of thermoplastic polyurethanes (TPUs) based on poly(ɛ-caprolactone)-b-poly(ethylene glycol)-b-poly(ɛ-caprolactone) (PCL-b-PEG-b-PCL) triblock copolymers and hexamethylene diisocyanate (HDI) were developed with PEG contents varying between 30 and 70 mol%. These showed excellent mechanical properties not only when dry, but also when hydrated: TPUs prepared from PCL-b-PEG-b-PCL with PEG of Mn 6 kg/mol (PCL7-PEG6-PCL7) took up 122 wt.% upon hydration and had an E-modulus of 52 ± 10 MPa, a tensile strength of 1

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41

Kim, Junki, Md Nurunnabi, Yeon Jeong Oh, Sung Young Park, and Yong-kyu Lee. "Herceptin conjugated PCL-PEG-PCL triblock copolymer for cancer targeting and imaging." Macromolecular Research 20, no. 8 (2012): 875–82. http://dx.doi.org/10.1007/s13233-012-0172-5.

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42

saghebasl, Solmaz, Soodabeh Davaran, Reza Rahbarghazi, Azadeh Montaseri, Roya Salehi, and Ali Ramazani. "Synthesis and in vitro evaluation of thermosensitive hydrogel scaffolds based on (PNIPAAm-PCL-PEG-PCL-PNIPAAm)/Gelatin and (PCL-PEG-PCL)/Gelatin for use in cartilage tissue engineering." Journal of Biomaterials Science, Polymer Edition 29, no. 10 (2018): 1185–206. http://dx.doi.org/10.1080/09205063.2018.1447627.

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Poudel, Sagun, Prabhat R. Napit, Karen P. Briski, and George Mattheolabakis. "Oral Delivery of Nucleic Acids with Passive and Active Targeting to the Intestinal Tissue Using Polymer-Based Nanocarriers." Pharmaceutics 13, no. 7 (2021): 1075. http://dx.doi.org/10.3390/pharmaceutics13071075.

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Despite the apparent advantages for long-term treatment and local therapies against intestinal diseases, the oral delivery of nucleic acids has been challenging due to unfavorable physiological conditions for their stability. In this study, a novel nanodelivery system of PEG-PCL nanoparticles with encapsulated nucleic acids–mannosylated PEI (Man-PEI) complexes was developed for intestinal delivery. We complexed model nucleic acids with Man-PEI at the optimal N/P ratio of 20:1 for in vitro and in vivo analyses. Cells were transfected in vitro and analyzed for gene expression, receptor-mediated

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Conte, Claudia, Giovanni Dal Poggetto, Benjamin J. Swartzwelter, et al. "Surface Exposure of PEG and Amines on Biodegradable Nanoparticles as a Strategy to Tune Their Interaction with Protein-Rich Biological Media." Nanomaterials 9, no. 10 (2019): 1354. http://dx.doi.org/10.3390/nano9101354.

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Nanoparticles (NPs) based on amphiphilic block copolymers of polyethylene glycol (PEG) and biodegradable polyesters are of particular current interest in drug nanodelivery due to their easily manipulated properties. The interaction of these NPs with biological environments is highly influenced by shell features, which drive biological identity after administration. To widen the strategies available for tuning particle surface chemistry, here we developed a panel of amine-bearing PEGylated NPs with a poly(ε-caprolactone) (PCL) core for the delivery of lipophilic drugs, and investigated the impa

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Chen, Hsuan, Shyh-Yuan Lee, and Yuan-Min Lin. "Synthesis and Formulation of PCL-Based Urethane Acrylates for DLP 3D Printers." Polymers 12, no. 7 (2020): 1500. http://dx.doi.org/10.3390/polym12071500.

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In this study, three PCL-based polyurethane acrylates were synthesized and further formulated into twelve resins for digital light processing (DLP) 3D printing. Three PCL diols with different molecular weights were synthesized via ring-opening reaction of ε-caprolactone on diethylene glycol, with the catalyst stannous octoate. Isophorone diisocyanate (IPDI) was reacted with 2-hydroxyethyl acrylate (2-HEA) and the PCL diols form PCL-based polyurethane acrylates. Twelve resins composed of different percentages of PCL-based polyurethane acrylates, poly (ethylene glycol) diacrylate (PEGDA), propyl

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Fan, Yu Jiang, Jie Liang, Guo Ping Chen, Tetsuya Tateishi, Zhong Wei Gu та Xing Dong Zhang. "Star-Shaped Poly (Γ-Caprolactone-b-Ethylene Glycol): Synthesis, Characterization and Aggregation Behavior". Key Engineering Materials 342-343 (липень 2007): 725–28. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.725.

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Linear and Star-shaped PCL-b-PEG copolymers were synthesized through a two step process, including the first step to synthesize the star-shaped PCL through ring-opening polymerization of Γ-caprolactone initiated from multi-functional alcohol under the existence of tin(II) ethylhexanoate [Sn(Oct)2] catalyst, and the following step to couple the obtained star-shaped PCL with PEG segments using bi-functional linker. The structure of the polymers was confirmed by IR, NMR, GPC, et al. The aggregation behaviors of the star-shape copolymers were compared with that of the linear block copolymer with c

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Khodaverdi, Elham, Khadijeh Delroba, Fatemeh Mohammadpour, et al. "In-vitro Release Evaluation of Growth Hormone from an Injectable In-Situ Forming Gel Using PCL-PEG-PCL Thermosensitive Triblock." Current Drug Delivery 17, no. 2 (2020): 174–83. http://dx.doi.org/10.2174/1567201817666200120120105.

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Objective: An injectable long acting In-Situ Forming Gel (ISFG) of human Growth Hormone (hGH) was prepared by using triblock PCL-‐PEG-‐PCL (Mw 1500-1500-1500). Ring-Opening Polymerization (ROP) of triblock using microwave was applied. Methods: The BCA protein assay Kit was used to determine the concentration of hGH in the in-vitro release medium. Finally, Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE) tests and Circular Dichroism (CD) spectrum were done to approve the stability of released hGH. The result of ROP demonstrated that the proportion of PCL to PEG accorded wi

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Liu, Xue, Yu Hou, Xiuping Tang, et al. "Multicompartment micelles based on hierarchical co-assembly of PCL-b-PEG and PCL-b-P4VP diblock copolymers." RSC Advances 6, no. 7 (2016): 5312–19. http://dx.doi.org/10.1039/c5ra22299k.

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Multicompartment micelles with various morphologies were preparedviadirected stepwise self-assembly using pre-assembled subunits, which were first constructed through the co-assembly of two amphiphilic diblock copolymer: PCL-b-PEG and PCL-b-P4VP.

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Zhang, Linhua, Zhuo Chen, Hai Wang, et al. "Preparation and evaluation of PCL–PEG–PCL polymeric nanoparticles for doxorubicin delivery against breast cancer." RSC Advances 6, no. 60 (2016): 54727–37. http://dx.doi.org/10.1039/c6ra04687h.

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DOX-loaded polymeric NPs based on PCL–PEG–PCL triblock copolymers were successfully prepared and showed highly efficient targeting and accumulation in tumor via EPR effect. The prepared NPs would be a promising nanosized DDS for cancer therapy.

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Payyappilly, Sanal, Santanu Dhara, and Santanu Chattopadhyay. "Thermoresponsive biodegradable PEG-PCL-PEG based injectable hydrogel for pulsatile insulin delivery." Journal of Biomedical Materials Research Part A 102, no. 5 (2013): 1500–1509. http://dx.doi.org/10.1002/jbm.a.34800.

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