Academic literature on the topic 'Reassortment'

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Journal articles on the topic "Reassortment"

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Lycett, S. J., G. Baillie, E. Coulter, et al. "Estimating reassortment rates in co-circulating Eurasian swine influenza viruses." Journal of General Virology 93, no. 11 (2012): 2326–36. http://dx.doi.org/10.1099/vir.0.044503-0.

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Swine have often been considered as a mixing vessel for different influenza strains. In order to assess their role in more detail, we undertook a retrospective sequencing study to detect and characterize the reassortants present in European swine and to estimate the rate of reassortment between H1N1, H1N2 and H3N2 subtypes with Eurasian (avian-like) internal protein-coding segments. We analysed 69 newly obtained whole genome sequences of subtypes H1N1–H3N2 from swine influenza viruses sampled between 1982 and 2008, using Illumina and 454 platforms. Analyses of these genomes, together with prev
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Barrat-Charlaix, Pierre, Timothy G. Vaughan, and Richard A. Neher. "TreeKnit: Inferring ancestral reassortment graphs of influenza viruses." PLOS Computational Biology 18, no. 8 (2022): e1010394. http://dx.doi.org/10.1371/journal.pcbi.1010394.

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When two influenza viruses co-infect the same cell, they can exchange genome segments in a process known as reassortment. Reassortment is an important source of genetic diversity and is known to have been involved in the emergence of most pandemic influenza strains. However, because of the difficulty in identifying reassortments events from viral sequence data, little is known about its role in the evolution of the seasonal influenza viruses. Here we introduce TreeKnit, a method that infers ancestral reassortment graphs (ARG) from two segment trees. It is based on topological differences betwe
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Macken, Catherine A., Richard J. Webby, and William J. Bruno. "Genotype turnover by reassortment of replication complex genes from avian Influenza A virus." Journal of General Virology 87, no. 10 (2006): 2803–15. http://dx.doi.org/10.1099/vir.0.81454-0.

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Reassortment among the RNA segments of Influenza A virus caused the two most recent human influenza pandemics; recently, reassortment has generated viral genotypes associated with outbreaks of avian H5N1 influenza in Asia and Europe. A statistical analysis has been developed for the systematic identification and characterization of reassortant viruses. The analysis was applied to the genes of the replication complex of 152 avian influenza A viruses isolated between 1966 and 2004 from predominantly terrestrial and domestic aquatic avian species. The results indicated that reassortment among the
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WAN, XIU-FENG, MUFIT OZDEN, and GUOHUI LIN. "UBIQUITOUS REASSORTMENTS IN INFLUENZA A VIRUSES." Journal of Bioinformatics and Computational Biology 06, no. 05 (2008): 981–99. http://dx.doi.org/10.1142/s0219720008003813.

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The influenza A virus is a negative-stranded RNA virus composed of eight segmented RNA molecules, including polymerases (PB2, PB1, PA), hemagglutinin (HA), nucleoprotein (NP), neuraminidase (NA), matrix protein (MP), and nonstructure gene (NS). The influenza A viruses are notorious for rapid mutations, frequent reassortments, and possible recombinations. Among these evolutionary events, reassortments refer to exchanges of discrete RNA segments between co-infected influenza viruses, and they have facilitated the generation of pandemic and epidemic strains. Thus, identification of reassortments
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Tao, Hui, Lian Li, Maria C. White, John Steel, and Anice C. Lowen. "Influenza A Virus Coinfection through Transmission Can Support High Levels of Reassortment." Journal of Virology 89, no. 16 (2015): 8453–61. http://dx.doi.org/10.1128/jvi.01162-15.

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ABSTRACTThe reassortment of gene segments between influenza viruses increases genomic diversity and plays an important role in viral evolution. We have shown previously that this process is highly efficient within a coinfected cell and, given synchronous coinfection at moderate or high doses, can give rise to ∼60 to 70% of progeny shed from an animal host. Conversely, reassortmentin vivocan be rendered undetectable by lowering viral doses or extending the time between infections. One might also predict that seeding of transmitted viruses into different sites within the target tissue could limi
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Dlugolenski, Daniel, Les Jones, Elizabeth Howerth, David Wentworth, S. Mark Tompkins, and Ralph A. Tripp. "Swine Influenza Virus PA and Neuraminidase Gene Reassortment into Human H1N1 Influenza Virus Is Associated with an Altered Pathogenic Phenotype Linked to Increased MIP-2 Expression." Journal of Virology 89, no. 10 (2015): 5651–67. http://dx.doi.org/10.1128/jvi.00087-15.

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ABSTRACTSwine are susceptible to infection by both avian and human influenza viruses, and this feature is thought to contribute to novel reassortant influenza viruses. In this study, the influenza virus reassortment rate in swine and human cells was determined. Coinfection of swine cells with 2009 pandemic H1N1 virus (huH1N1) and an endemic swine H1N2 (A/swine/Illinois/02860/09) virus (swH1N2) resulted in a 23% reassortment rate that was independent of α2,3- or α2,6-sialic acid distribution on the cells. The reassortants had altered pathogenic phenotypes linked to introduction of the swine vir
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Feoktistova, Sofya G., Alexandra O. Ivanova, Egor P. Degtyarev, Daria I. Smirnova, Pavel Yu Volchkov, and Andrei A. Deviatkin. "Phylogenetic Insights into H7Nx Influenza Viruses: Uncovering Reassortment Patterns and Geographic Variability." Viruses 16, no. 11 (2024): 1656. http://dx.doi.org/10.3390/v16111656.

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Influenza A viruses (IAVs), which belong to the Orthomyxoviridae family, are RNA viruses characterized by a segmented genome that allows them to evolve and adapt rapidly. These viruses are mainly transmitted by wild waterfowl. In this study, we investigated the evolutionary processes of H7Nx (H7N1, H7N2, H7N3, H7N4, H7N5, H7N6, H7N7, H7N8, H7N9) viruses, which pose a significant pandemic risk due to the known cases of human infection and their potential for rapid genetic evolution and reassortment. The complete genome sequences of H7Nx influenza viruses (n = 3239) were compared between each ot
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Müller, Nicola F., Ugnė Stolz, Gytis Dudas, Tanja Stadler, and Timothy G. Vaughan. "Bayesian inference of reassortment networks reveals fitness benefits of reassortment in human influenza viruses." Proceedings of the National Academy of Sciences 117, no. 29 (2020): 17104–11. http://dx.doi.org/10.1073/pnas.1918304117.

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Reassortment is an important source of genetic diversity in segmented viruses and is the main source of novel pathogenic influenza viruses. Despite this, studying the reassortment process has been constrained by the lack of a coherent, model-based inference framework. Here, we introduce a coalescent-based model that allows us to explicitly model the joint coalescent and reassortment process. In order to perform inference under this model, we present an efficient Markov chain Monte Carlo algorithm to sample rooted networks and the embedding of phylogenetic trees within networks. This algorithm
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Taylor, Kishana Y., Ilechukwu Agu, Ivy José, et al. "Influenza a virus reassortment is strain dependent." PLOS Pathogens 19, no. 3 (2023): e1011155. http://dx.doi.org/10.1371/journal.ppat.1011155.

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RNA viruses can exchange genetic material during coinfection, an interaction that creates novel strains with implications for viral evolution and public health. Influenza A viral genetic exchange can occur when genome segments from distinct strains reassort in coinfected cells. Predicting potential genomic reassortment between influenza strains has been a long-standing goal. Experimental coinfection studies have shed light on factors that limit or promote reassortment. However, determining the reassortment potential between diverse Influenza A strains has remained elusive. To address this chal
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Ding, Xiao, Xuye Yuan, Longfei Mao, Aiping Wu, and Taijiao Jiang. "FluReassort: a database for the study of genomic reassortments among influenza viruses." Briefings in Bioinformatics 21, no. 6 (2019): 2126–32. http://dx.doi.org/10.1093/bib/bbz128.

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Abstract Genomic reassortment is an important genetic event in the generation of emerging influenza viruses, which can cause numerous serious flu endemics and epidemics within hosts or even across different hosts. However, there is no dedicated and comprehensive repository for reassortment events among influenza viruses. Here, we present FluReassort, a database for understanding the genomic reassortment events in influenza viruses. Through manual curation of thousands of literature references, the database compiles 204 reassortment events among 56 subtypes of influenza A viruses isolated in 37
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Dissertations / Theses on the topic "Reassortment"

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Van, den Bergh Carien. "Reassortment of bluetongue virus vaccine serotypes in cattle." Diss., University of Pretoria, 2016. http://hdl.handle.net/2263/53313.

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Bluetongue (BT) is a non-contagious viral disease of domestic and wild ruminants. Bluetongue virus (BTV), an Orbivirus that belongs to the family Reoviridae, is the causing agent of the disease. The virus consists of a ten segmented double stranded (ds) RNA genome and currently 27 serotypes have been identified worldwide. The virus is transmitted by Culicoide biting midges (Diptera: Ceratoponidae) and the occurrence of the disease depends on the presence and abundance of competent vectors. In South Africa most European ovine breeds are more susceptible to the disease than indigenous sheep, whi
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Urquidi, Virginia. "Genome segment reassortment between two members of the bunyaviridae." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306612.

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Chen, Kuang-Yu. "Mechanistic study and prediction of influenza A virus genetic reassortment." Thesis, Université de Paris (2019-....), 2019. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=4762&f=29825.

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La nature segmentée du génome des virus de la grippe A (IAV) permet une évolution rapide par réassortiment génétique. Bien que le nombre théorique de génotypes issus d'un réassortiment entre deux virus soit de 256 (28), la panoplie complète des différents génotypes n'a jamais été observée et certains gènes ont tendance à co-ségréger, suggérant que le réassortiment génétique est biaisé. Cependant, à ce jour, les contraintes qui façonnent le réassortiment génétique restent largement méconnues. L'objectif de mon projet est de progresser dans la compréhension des règles sous-jacentes au réassortim
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Villa, Mara [Verfasser], Michael [Gutachter] Lässig, and Andreas [Gutachter] Beyer. "The role of reassortment in the evolution of seasonal influenza / Mara Villa ; Gutachter: Michael Lässig, Andreas Beyer." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/116372842X/34.

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Nindo, Fredrick Nzabanyi. "Exploring the phylodynamics, genetic reassortment and RNA secondary structure formation patterns of orthomyxoviruses by comparative sequence analysis." Doctoral thesis, Faculty of Health Sciences, 2019. https://hdl.handle.net/11427/31729.

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RNA viruses are among the most virulent microorganisms that threaten the health of humans and livestock. Among the most socio-economically important of the known RNA viruses are those found in the family Orthomyxovirus. In this era of rapid low-cost genome sequencing and advancements in computational biology techniques, many previously difficult research questions relating to the molecular epidemiology and evolutionary dynamics of these viruses can now be answered with ease. Using sequence data together with associated meta-data, in chapter two of this dissertation I tested the hypothesis that
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Parvin, Rokshana. "Molecular epidemiology and biological properties of avian influenza viruses of subtype H5N1 and H9N2." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-162858.

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Rokshana Parvin Molecular epidemiology and biological properties of avian influenza viruses of subtype H5N1 and H9N2 Institute of Virology Submitted in November 2014 Pages 106, Figures 7, Table 1, References 339, Publications 4 Keywords: Avian Influenza Virus, H5N1, H9N2, Reassortment, Mutation, Replication and Growth kinetics Introduction Avian influenza viruses (AIVs) are the major cause of significant disease outbreaks with high morbidity and mortality worldwide in domestic birds resulting in great economic losses. Especially the subtypes of highly pathogenic avian influenza viruses (HPAIV)
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Audsley, Jennifer M., and jennifer audsley@med monash edu au. "Alternative Approaches In The Preparation And Growth Of Influenza B Vaccine Viruses." RMIT University. Applied Sciences, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080414.141937.

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Influenza B viruses are a significant cause of disease and influenza B antigens are present in all human vaccines. Achieving suitable yields of seed viruses is often difficult for vaccine manufacturers. With influenza A viruses increases in yields have been achieved by the preparation of reassortants between a high-yielding donor strain and an epidemic strain. However, reassortment of influenza B viruses for the preparation of seeds has not been usually undertaken due to the lack suitable donor strains. Such an approach, which formed the basis of this thesis, could improve vaccine yields, lowe
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Kreibich, Anne [Verfasser]. "Untersuchungen zum Reassortment von aviären und humanen Influenza-A-Viren des Subtyps H3 unter Verwendung der Reversen Genetik. / Anne Kreibich." Greifswald : Universitätsbibliothek Greifswald, 2015. http://d-nb.info/1080382143/34.

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Dudas, Gytis. "Inference of evolutionary and ecological processes from reticulate evolution in RNA viruses." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20442.

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RNA viruses have the fastest evolutionary rates amongst protein-coding organisms on the planet. Ease of sequencing, advanced techniques of analysis and global health and economic concerns have all contributed to the recognition of RNA viruses as a robust research platform. Phylogenetic methods have been at the forefront of analytical techniques used to understand the dynamics of RNA viruses - during natural circulation in populations and in individual hosts, within epidemics, across species barriers and over billions of years that viruses have been around. Most of the work presented in this th
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Kirsanovs, Sina [Verfasser]. "Genetic reassortment between members of different Dobrava-Belgrade virus lineages and allocation of innate immune response modulation to praticular genome segments / Sina Kirsanovs." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1028494025/34.

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Books on the topic "Reassortment"

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Alexander, D. J., N. Phin, and M. Zuckerman. Influenza. Edited by I. H. Brown. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0037.

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Influenza is a highly infectious, acute illness which has affected humans and animals since ancient times. Influenza viruses form the Orthomyxoviridae family and are grouped into types A, B, and C on the basis of the antigenic nature of the internal nucleocapsid or the matrix protein. Infl uenza A viruses infect a large variety of animal species, including humans, pigs, horses, sea mammals, and birds, occasionally producing devastating pandemics in humans, such as in 1918 when it has been estimated that between 50–100 million deaths occurred worldwide.There are two important viral surface glyc
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Book chapters on the topic "Reassortment"

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Steel, John, and Anice C. Lowen. "Influenza A Virus Reassortment." In Influenza Pathogenesis and Control - Volume I. Springer International Publishing, 2014. http://dx.doi.org/10.1007/82_2014_395.

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Pringle, C. R. "Genetics and Genome Segment Reassortment." In The Bunyaviridae. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-1364-7_8.

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Li, Chengjun, and Hualan Chen. "Enhancement of Influenza Virus Transmission by Gene Reassortment." In Influenza Pathogenesis and Control - Volume I. Springer International Publishing, 2014. http://dx.doi.org/10.1007/82_2014_389.

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Trevella, Wendy, and Bede Morris. "Reassortment of Cell Populations within the Lymphoid Apparatus of the Sheep." In Ciba Foundation Symposium 71 - Blood Cells and Vessel Walls. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720547.ch8.

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"Genetic Reassortment." In Handbook of Disease Burdens and Quality of Life Measures. Springer New York, 2010. http://dx.doi.org/10.1007/978-0-387-78665-0_5714.

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"reassortment, n." In Oxford English Dictionary, 3rd ed. Oxford University Press, 2023. http://dx.doi.org/10.1093/oed/4426197492.

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Burnett, John. "The generation of variation-II The importance and diversity of inbreeding and outbreeding." In Fungal Populations and Species. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780198515524.003.0008.

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Abstract Recombination in fungi can involve the reassortment of genes, chromosomes, extra-chromosomal elements, or even whole nuclei. The first two occur most frequently at meiosis but mitotic recombination is possible. The reassortment of extra-chromosomal elements and whole nuclei consequential on hyphal anastomoses, leading to heterokaryosis and heteroplasmon formation, is also possible and can be detected. The basic processes concerned in sexual and parasexual recombination have been outlined earlier (see Chapter 1, section 1.4).
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Doherty, Peter C. "Single-Host Human Pathogens." In Pandemics. Oxford University Press, 2013. http://dx.doi.org/10.1093/wentk/9780199898107.003.0007.

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Is an infection that is already widespread in humans likely to cause a pandemic? As discussed previously, that really gets down to a matter of terminology. The influenza A viruses that emerge as a consequence of genetic reassortment, perhaps between viruses circulating in us...
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Strauss, James H. "Recombination in the Evolution of RNA Viruses." In Emerging Viruses. Oxford University PressNew York, NY, 1993. http://dx.doi.org/10.1093/oso/9780195074444.003.0023.

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Abstract Recombination is a fundamental mechanism of genetic variation that results from the reshuffling of genetic material by processes including reassortment of chromosomes, breakage of a chromosome followed by rejoining to a chromosome from a second parent, or by a replicase enzyme switching strands during replication of the nucleic acid. Recombination in viruses is now known to arise from all of these mechanisms. The high frequency recombination characteristic of influenza virus and other viruses with segmented genomes has been well documented. This occurs by reassortment of the individua
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Banda, Alejandro. "Understanding the molecular biology of avian viruses and their role in poultry health." In Optimising poultry flock health. Burleigh Dodds Science Publishing, 2022. http://dx.doi.org/10.19103/as.2022.0104.01.

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Different molecular aspects of avian viruses are presented such as the role and importance of capsid proteins and viral glycoproteins in viral pathogenesis, in development of diagnostic methods and the creation of recombinant vaccines is discussed. Mechanisms of viral evolution such as mutation, recombination and reassortment are included, and their role in the origin of diverse influenza, infectious bursal disease, avian reovirus is commented.
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Conference papers on the topic "Reassortment"

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Bae, Se-Eun. "Pattern Analysis of Pandemic/epidemic/reassortment of Influenza Virus." In Healthcare and Nursing 2016. Science & Engineering Research Support soCiety, 2016. http://dx.doi.org/10.14257/astl.2016.128.28.

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Yurovsky, Alisa, and Bernard M. E. Moret. "FluRF, an automated flu virus reassortment finder based on phylogenetic trees." In 2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2010). IEEE, 2010. http://dx.doi.org/10.1109/bibm.2010.5706632.

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Yan, Shaomin, and Guang Wu. "Notice of Retraction: Reasons for Cross-Species Infection and Cross-Subtype Reassortment in Nucleoproteins from Influenza A Virus." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5780112.

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Nagarajan, Niranjan, and Carl Kingsford. "Uncovering Genomic Reassortments among Influenza Strains by Enumerating Maximal Bicliques." In 2008 IEEE International Conference on Bioinformatics and Biomedicine. IEEE, 2008. http://dx.doi.org/10.1109/bibm.2008.78.

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Nandy, Ashesh, and Subhas Basak. "Interdependence of Influenza HA and NA and possibilities of new reassortments." In MOL2NET, International Conference on Multidisciplinary Sciences. MDPI, 2015. http://dx.doi.org/10.3390/mol2net-1-b006.

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Reports on the topic "Reassortment"

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Klement, Eyal, Elizabeth Howerth, William C. Wilson, et al. Exploration of the Epidemiology of a Newly Emerging Cattle-Epizootic Hemorrhagic Disease Virus in Israel. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7697118.bard.

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In September 2006 an outbreak of 'Bluetongue like' disease struck the cattle herds in Israel. Over 100 dairy and beef cattle herds were affected. Epizootic hemorrhagic disease virus (EHDV) (an Orbivirusclosely related to bluetongue virus (BTV)), was isolated from samples collected from several herds during the outbreaks. Following are the aims of the study and summary of the results: which up until now were published in 6 articles in peer-reviewed journals. Three more articles are still under preparation: 1. To identify the origin of the virus: The virus identified was fully sequenced and comp
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