Academic literature on the topic 'REV liposomes'

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Journal articles on the topic "REV liposomes"

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Khusbu, ,., Avinash Kumar Gupta, Manish Kumar Gupta, and Vijay Sharma. "Development of liposome encapsulated curcumin for treatment of arthritis." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 374–81. http://dx.doi.org/10.22270/jddt.v9i4.3062.

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Liposomesof curcumin was prepared by Thin Film Hydration method (TFH) and Reverse Phase Evaporation Method (REV) methods and Freeze-thaw (F-T) cycles were carried out for liposomes prepared by both the methods, then optimized with regard to percentage drug entrapment by changing various process and formulation parameters, various compositions of optimized liposomal batches along with their PDE and mean vesicle size values are recorded. Prepared liposomes prior to size reduction were suitable for nasal delivery as then vesicle size distribution was in range of 10-20 pm that is required for nasa
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Vitali, Alberto, Patrizia Paolicelli, Barbara Bigi, et al. "Liposome Encapsulation of the Palmitoyl–KTTKS Peptide: Structural and Functional Characterization." Pharmaceutics 16, no. 2 (2024): 219. http://dx.doi.org/10.3390/pharmaceutics16020219.

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In this study, the amphiphilic N-palmitoyl–KTTKS peptide was integrated in the bilayer of egg-derived phosphatidylcholine (PC) vesicles using two different preparation methods, namely thin-film evaporation (TLE) and reverse-phase evaporation (REV). Both the REV and TLE methods allowed for the formation of homogeneous liposome dispersions (PdI < 0.20) with mean hydrodynamic diameters of <100 nm and <200 nm, respectively, a net negative surface charge and a percentage of structured phospholipids higher than 90%. The inclusion of the amphiphilic N-palmitoyl–KTTKS peptide within phospholi
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Sharma, Neeraj, Abhilasha Singh, Pragati Baghel, Vikas Chandra Sharma, Gajendra Singh Rathore, and Shivani Vishwakarma. "Formulation Characterization and Optimization of Photosensitive Liposomes for Targeted Drug Delivery Using UV Light Activation." Journal of Neonatal Surgery 14, no. 6S (2025): 481–87. https://doi.org/10.52783/jns.v14.2255.

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This study explores the formulation, characterization, and optimization of photosensitive liposomes for targeted drug delivery activated by UV light. Liposomes, self-forming spherical vesicles made of phospholipids, are effective carriers for drugs, offering the advantage of localized delivery and reduced systemic distribution. The research focuses on incorporating non-steroidal anti-inflammatory drugs (NSAIDs), specifically Ketoprofen (KP), into liposomes using the reverse phase evaporation (REV) method, achieving high encapsulation efficiency. Optimization studies revealed that increasing ch
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Nasedkin, Alexandr, Jan Davidsson, and Mont Kumpugdee-Vollrath. "Determination of nanostructure of liposomes containing two model drugs by X-ray scattering from a synchrotron source." Journal of Synchrotron Radiation 20, no. 5 (2013): 721–28. http://dx.doi.org/10.1107/s0909049513020074.

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Small-angle X-ray scattering has been employed to study how the introduction of paracetamol and acetylsalicylic acid into a liposome bilayer system affects the system's nanostructure. An X-ray scattering model, developed for multilamellar liposome systems [Pabstet al.(2000),Phys. Rev. E,62, 4000–4009], has been used to fit the experimental data and to extract information on how structural parameters, such as the number and thickness of the bilayers of the liposomes, thickness of the water layer in between the bilayers, size and volume of the head and tail groups, are affected by the drugs and
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Cheraga, Nihad, Ammar Ouahab, Yan Shen, and Ning-Ping Huang. "Characterization and Pharmacokinetic Evaluation of Oxaliplatin Long-Circulating Liposomes." BioMed Research International 2021 (April 20, 2021): 1–14. http://dx.doi.org/10.1155/2021/5949804.

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The clinical efficacy of Oxaliplatin (L-OHP) is potentially limited by dose-dependent neurotoxicity and high partitioning to erythrocytes in vivo. Long-circulating liposomes could improve the pharmacokinetic profile of L-OHP and thus enhance its therapeutic efficacy and reduce its toxicity. The purpose of this study was to prepare L-OHP long-circulating liposomes (L-OHP PEG lip) by reverse-phase evaporation method (REV) and investigate their pharmacokinetic behavior based on total platinum in rat plasma using atomic absorption spectrometry (AAS). A simple and a sensitive AAS method was develop
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Lim, Sun Kyung, Heon Joo Park, Eun Kyung Choi, and Jin Seok Kim. "Long-Circulating, Temperature-Sensitive and EGFR-Targeted Liposomes for Drugs Delivery." Key Engineering Materials 342-343 (July 2007): 537–40. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.537.

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Effectiveness of epidermal growth factor receptor(EGFR)-targeted, long circulating and temperature-sensitive liposomes(TSLs) is described using sterically stabilized gemcitabine-loaded liposomes in vitro. Development of long-circulating formulation of TSLs with the EGFR antibody attached was designed to expect an increase in binding and drug delivery efficiency to the target cells such as non-small cell lung cancer cells(A549) and human pancreatic carcinoma cells(PANC- 1). New TSLs were prepared using DPPC:DMPC:DSPC(4:1:1 molar ratio) by the REV method. Differential scanning calorimetry of TSL
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Garello, Francesca, Rachele Stefania, Silvio Aime, Enzo Terreno, and Castelli Daniela Delli. "Successful Entrapping of Liposomes in Glucan Particles: An Innovative Micron-Sized Carrier to Deliver Water-Soluble Molecules." Mol Pharm. 11, no. 10 (2014): 3760–5. https://doi.org/10.1021/mp500374f.

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Glucan particles (GPs) are monodisperse microspheres derived from baker's yeast and represent an interesting class of microcarriers for theranostic applications as they show a high affinity toward immune system cells. The typical loading strategy was to harness the ability of the molecule to be loaded to interact with nano-/microassembled systems through electrostatic or hydrophobic forces. However, small water-soluble chemicals could not be steadily retained by the leaky shell of GPs. In this work, we propose an alternative loading approach for small water-soluble compounds that is based
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Okada, E., S. Sasaki, N. Ishii, et al. "Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens." Journal of Immunology 159, no. 7 (1997): 3638–47. http://dx.doi.org/10.4049/jimmunol.159.7.3638.

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Abstract A DNA vaccine constructed with the CMV promoter conjugated to env gp160 and rev genes has been shown to induce an effective Th1-type immune response when inoculated via an intramuscular route. In the present study, we obtained high levels of both humoral and cell-mediated immune activity by intranasal administration of this DNA vaccine. The production of mucosal IgA Ab in feces and vaginal fluid was stimulated significantly by intranasal DNA administration. This route of administration resulted in a significant level of HIV-1-neutralizing Abs in feces and serum. Cytokine assays reveal
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Cyboran-Mikołajczyk, Sylwia, Przemysław Sareło, Robert Pasławski, et al. "Impact of Liposomal Drug Formulations on the RBCs Shape, Transmembrane Potential, and Mechanical Properties." International Journal of Molecular Sciences 22, no. 4 (2021): 1710. http://dx.doi.org/10.3390/ijms22041710.

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Liposomal technologies are used in order to improve the effectiveness of current therapies or to reduce their negative side effects. However, the liposome–erythrocyte interaction during the intravenous administration of liposomal drug formulations may result in changes within the red blood cells (RBCs). In this study, it was shown that phosphatidylcholine-composed liposomal formulations of Photolon, used as a drug model, significantly influences the transmembrane potential, stiffness, as well as the shape of RBCs. These changes caused decreasing the number of stomatocytes and irregular shapes
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Chronopoulou, Laura, Francesca Falasca, Federica Di Fonzo, Ombretta Turriziani, and Cleofe Palocci. "siRNA Transfection Mediated by Chitosan Microparticles for the Treatment of HIV-1 Infection of Human Cell Lines." Materials 15, no. 15 (2022): 5340. http://dx.doi.org/10.3390/ma15155340.

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Gene delivery is the basis for developing gene therapies that, in the future, may be able to cure virtually any disease, including viral infections. The use of short interfering RNAs (siRNAs) targeting viral replication is a novel strategy for treating HIV-1 infection. In this study, we prepared chitosan particles containing siRNA tat/rev via ionotropic gelation. Chitosan-based particles were efficiently internalized by cells, as evidenced by fluorescence microscopy. The antiviral effect of chitosan-based particles was studied on the C8166 cell line infected with HIV-1 and compared with the us
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Dissertations / Theses on the topic "REV liposomes"

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Voelker, Dirk. "Interactions of Ruthenium Red with Phospholipid Vesicles." PDXScholar, 1994. https://pdxscholar.library.pdx.edu/open_access_etds/4881.

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We have studied the electrostatic and other interactions of the inorganic, hexavalent dye Ruthenium Red (RR) with phospholipid vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS) or phosphatidylinositol (Pl) in various mixtures and concentrations. Experiments were based on spectrophotometric absorption measurements which compared RR concentrations in the presence and in the absence of liposomes at different dye concentrations. Multilamellar liposomes were obtained by handshaken preparations. Five freeze-and-thaw cycles of the lipid-RR suspension produced an ion equilibriu
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McNeeley, Kathleen Margaret. "Modulating liposomal stealth properties to evade RES and target tumors." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26650.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Ravi V. Bellamkonda; Committee Member: Ananth V. Annapragada; Committee Member: Andrew Lyon; Committee Member: Gang Bao; Committee Member: Niren Murthy. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Daswani, Varsha. "Fluorescence and aggregation properties of the anti-cancer drug, CA4P, in archaeal liposomes." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/334013.

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Biomedical Sciences<br>Ph.D.<br>Combretastatin A4 phosphate (CA4P) is a potent vascular disrupting agent utilized in the treatment of cancer. The observed rapid vascular shutdown post administration as well as its potency at 1/10th of the established maximum tolerated dose (MTD) have made it one of the most prevalent tubulin binding agents. CA4P is currently involved in 19 clinical trials. Unfortunately, as is the case with most forms of chemotherapy, the off target effects associated with its use can be prohibitive for a large percentage of cancer patients. The advantages associated with the
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Santos, Marina. "ANALYTICAL POTENTIAL OF POLYMERIZED LIPOSOMES BOUND TO LANTHANIDE IONS FOR QUALITATIVE AND QUANTITATIVE ANALYSIS OF PROTEINS." Doctoral diss., University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2587.

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One of the intriguing features of biological systems is the prevalence of highly selective and often very strong interactions among different cellular components. Such interactions play a variety of organizational, mechanical, and physiological roles at the cellular and organism levels. Antigen-antibody complexes are representative examples of highly selective and potent interactions involving proteins. The marked specificity of protein-antibody complexes have led to a wide range of applications in cellular and molecular biology related research. They have become an integral research tool in t
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Santos, Marina. "ANALYTICAL POTENTIAL OF POLYMERIZED LIPOSOMES BOUND TO LANTHANIDE IONS FOR QUALITATIVE AND QUANTITATIVE ANALYSIS OF PROTEINS." Doctoral diss., University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2588.

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One of the intriguing features of biological systems is the prevalence of highly selective and often very strong interactions among different cellular components. Such interactions play a variety of organizational, mechanical, and physiological roles at the cellular and organism levels. Antigen-antibody complexes are representative examples of highly selective and potent interactions involving proteins. The marked specificity of protein-antibody complexes have led to a wide range of applications in cellular and molecular biology related research. They have become an integral research tool in t
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Ayesa, Umme. "CHARACTERIZATION OF THERMOSENSITIVE HYBRID ARCHAEOSOMES AND DPA-CY3[22,22]/POPC LIPOSOMES AND IN VITRO EVALUATION OF THEIR POTENTIAL USEFULNESS IN TARGETED DELIVERY AND CONTROLLED RELEASE." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/368614.

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Biochemistry<br>Ph.D.<br>One of earlier challenges in treating cancer was utilizing drugs that are powerful yet do not cause severe toxicity to patients. Although the use of liposomal drugs has somewhat met that challenge, our objective now is to create liposomal drugs with an even better drug efficacy and further reduced toxicity. Doxorubicin hydrochloride (DXO), for example, is an anticancer drug used to treat many types of cancers, but it is toxic to the gastrointestinal tract and the heart. Encapsulating DXO into liposomes as done in the first FDA-approved liposomal DXO, Doxil, minimizes t
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Rosano, Jenna Marie. "Engineering Nanoparticles for Targeted Delivery of Growth Factors to Prevent Cardiac Remodeling After an MI." Master's thesis, Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/82332.

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Mechanical Engineering<br>M.S.E.<br>Myocardial infarction (MI) is a leading cause of death in the United States, claiming the lives of approximately 500,000 people each year. The infarcted heart undergoes a compensatory process called cardiac remodeling, which adversely changes left ventricular (LV) size and function and eventually may lead to heart failure. To date, the only clinical treatments for this condition include surgical restoration of blood flow to the ischemic region (e.g., angioplasty), or pharmacological treatments (e.g., angiotensin converting enzyme inhibitors) which indirectly
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Chaineau, Mathilde. "Régulation du trafic vésiculaire : rôle de la protéine Hrb dans l'endocytose de la SNARE vésiculaire TI-VAMP/VAMP7." Paris 6, 2009. http://www.theses.fr/2009PA066022.

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Le trafic membranaire assure la communication entre les différents compartiments intracellulaires ainsi qu’entre les cellules et leur environnement via l’exocytose et l’endocytose. Les protéines SNARE vésiculaires (v-SNARE) et leurs partenaires à la membrane cible (t-SNARE) sont responsables de la fusion membranaire. Des travaux antérieurs ont montré le rôle de la v-SNARE TI-VAMP dans une voie d’exocytose impliquée dans la croissance neuritique et le remodelage de la membrane plasmique. Le domaine amino-terminal Longin de TI-VAMP régule l'activité fusogénique de la protéine et son ciblage. J'a
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Rescia, Vanessa Cristina [UNIFESP]. "REVs-Chi: um novo sistema particulado para encapsulação de macromoléculas terapêuticas." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/10065.

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Made available in DSpace on 2015-07-22T20:50:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-07-29<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A quitosana (Chi), a (1-4)-amino-2-desoxi-ƒÒ-glicana, e a forma desacetilada da quitina, um polissacarideo das conchas de crustaceos. As suas caracteristicas unicas como a carga positiva, biodegradabilidade, biocompatibilidade, atoxicidade e estrutura rigida fazem com que esta
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Gottschalk, Ingo. "Chromatographic Studies of Solute Interactions with Immobilized Red Blood Cells and Biomembranes." Doctoral thesis, Uppsala University, Department of Biochemistry, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2668.

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<p>Specific and non-specific interactions of solutes with immobilized biomembranes were studied using chromatographic methods. Liposomes, proteoliposomes and red blood cell (RBC) membrane vesicles were immobilized by a freeze-thawing procedure, whereas whole RBCs were adsorbed in the gel beds using electrostatic interaction, binding to wheat germ agglutinin (WGA) or the streptavidin-biotin interaction. </p><p>Superporous agarose gel with coupled WGA was the most promising matrix for RBC adsorption and allowed frontal chromatographic analyses of the cells for about one week. Dissociation consta
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Book chapters on the topic "REV liposomes"

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Farmer, M. C., S. A. Johnson, R. L. Beissinger, J. L. Gossage, A. B. Lynn, and K. A. Carter. "Liposome-Encapsulated Hemoglobin: A Synthetic Red Cell." In Advances in Experimental Medicine and Biology. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-7908-9_13.

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Kawaguchi, Akira T., Chieko Murayama, Fumiaki Yoshiba, Hiroyuki Furuya, Mariko Yamano, and Munetaka Haida. "Liposome-Encapsulated Hemoglobin: Potential Clinical Applications." In Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-40717-8_21.

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Rudolph, Alan S., Beth Goins, Frances Ligler, et al. "Liposome Encapsulated Hemoglobin; In-Vivo Efficacy of a Synthetic Red Cell Substitute." In Progress in Membrane Biotechnology. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-7454-0_15.

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Kato, Atsushi, and Tamotsu Kondo. "A Study of Liposome-Type Artificial Red Blood Cells Stabilized with Carboxymethyl Chitin." In Advances in Biomedical Polymers. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1829-3_27.

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Szebeni, J., E. E. Di Iorio, H. Hauser, and K. H. Winterhalter. "Some Structural and Functional Properties of Hemoglobin-Containing Liposomes (Hemosomes), A Potential Red Blood Cell Substitute." In Advances in Experimental Medicine and Biology. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-7908-9_15.

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Kaneda, Shinichi, Takanobu Ishizuka, Hiroshi Goto, and Hiroaki Kasukawa. "Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier: Technological Features, Manufacturing and Issues for Practical Application." In Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-40717-8_14.

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Klibanov, Alexander L., Vladimir P. Torchilin, and Samuel Zalipsky. "Long-Circulating Sterically Protected Liposomes." In Liposomes. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780199636556.003.0008.

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Abstract Soon after liposomes were proposed as vehicles for drug delivery and targeting, their major disadvantage was discovered: Typical liposome compositions rapidly exited the bloodstream and accumulated in the Kupffer cells in the liver, as well as in spleen macrophages (RES) (1). Various approaches to overcome this problem have been tested. Initially, the simple approach of blocking RES cells by administering an excess of ‘empty’ liposomes, a colloid dispersion or dextran sulfate was tested (2, 3). However, blocking RES is not the most appropriate approach for human therapy. On the other
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Brandl, M., and U. Massing. "Vesicular Phospholipid Gels." In Liposomes. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780199636556.003.0014.

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Abstract This chapter discusses some of the common limitations with small liposomes as drug carriers and how vesicular phospholipid gels can be used to circumvent them. The purpose of an intravenously injected liposomal drug carrier usually is to circulate in the bloodstream and carry the drug to the desired target organ or tissue. Under ideal circumstances the pharmacokinetics and biodistribution of the carrier-associated drug is merely dependent on the characteristics of the liposomes, not on the drug itself. Size and surface characteristics of the liposomes primarily determine the degree to
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Fenske, David B., Norbert Maurer, and Pieter R. Cullis. "Encapsulation of Weakly-Basic Drugs, Antisense Oligonucleotides, and Plasmid DNA within Large Unilamellar vesicles for Drug Delivery Applications." In Liposomes. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780199636556.003.0006.

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Abstract Liposomes are microscopic spheres consisting of one or more lipid bilayers arranged concentrically about a central aqueous core. Liposomes were first described over thirty-five years ago (1), and it was not long after that their usefulness as models of biological membranes and their potential as systems for the systemic delivery of drugs was recognized (2). Development of this potential required techniques for the generation of unilamellar vesicles and encapsulation of drugs and macromolecules within them. Although a wide variety of methods were developed for the formation of liposome
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"Encapsulation of Hemoglobin in Liposomes." In Red Blood Cell Substitutes. CRC Press, 1997. http://dx.doi.org/10.1201/9781482269796-14.

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Conference papers on the topic "REV liposomes"

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Matos, Anna L. L., Goreti Pereira, Beate S. Santos, and Adriana Fontes. "Fluorescent liposomes to probe how DOTAP lipid concentrations can change red blood cells homeostasis." In SPIE Biophotonics South America, edited by Cristina Kurachi, Katarina Svanberg, Bruce J. Tromberg, and Vanderlei S. Bagnato. SPIE, 2015. http://dx.doi.org/10.1117/12.2180957.

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Milbocker, Michael T., and Gilbert T. Feke. "A Model for the Blood Flow-Vessel Diameter Relation in the Retina." In Noninvasive Assessment of the Visual System. Optica Publishing Group, 1992. http://dx.doi.org/10.1364/navs.1992.mc2.

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Volumetric blood flow rate in the human retina is an important measure of its health. Total blood flow is measured by measuring the flow through the major arteries or veins of the retina. The technique involves measuring the spatial and time averaged blood speed V in individual vessels using LDV1 or a fluorescein angiography procedure such as microencapsulated liposomes2. A measure of the red blood cell column RBCC radius combined with V yields the volumetric blood flow rate. It is natural to determine blood flow rate as a function of vessel radius. Riva et al.3 report a functional dependence
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Gong, Xiabo, Shu Takagi, and Yoichiro Matsumoto. "A Numerical Simulation on the Deformed Behavior of Liposome and Red Blood Cells With the Immersed Boundary Method." In ASME 2008 Summer Bioengineering Conference. ASME, 2008. http://dx.doi.org/10.1115/sbc2008-193113.

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Ferguson, L., E. Hood, T. Shuvaeva, V. Shuvaev, V. Muzykantov, and J. S. Brenner. "Dual Targeted Red Blood Cell Hitchhiking: A Platform Liposomal Drug Delivery System to Improve Circulation Time and Increase Delivery to Target Organs." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2289.

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Reports on the topic "REV liposomes"

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Kanner, Joseph, Edwin Frankel, Stella Harel, and Bruce German. Grapes, Wines and By-products as Potential Sources of Antioxidants. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7568767.bard.

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Several grape varieties and red wines were found to contain large concentration of phenolic compounds which work as antioxidant in-vitro and in-vivo. Wastes from wine production contain antioxidants in large amounts, between 2-6% on dry material basis. Red wines but also white wines were found to prevent lipid peroxidation of turkey muscle tissues stored at 5oC. The antioxidant reaction of flavonoids found in red wines against lipid peroxidation were found to depend on the structure of the molecule. Red wine flavonoids containing an orthodihydroxy structure around the B ring were found highly
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