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Dissertations / Theses on the topic 'Reward circuit'

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1

Tian, Ju. "Neural Circuit Mechanisms Underlying Dopamine Reward Prediction Errors." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493547.

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Dopamine neurons are thought to facilitate learning by signaling reward prediction errors (RPEs), the discrepancy between actual and expected reward. However, how RPEs are calculated remains unknown. In Chapter 1, I tested the hypothesis that RPE signals in dopamine neurons are inherited entirely from the lateral habenula, by examining how lesions of the habenular complex affect the response of optogenetically-identified dopamine neurons in mice. I found that despite large lesions of habenula, dopamine neurons maintained features of RPE coding pertaining to phasic dopamine responses. Interesti
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2

Blancas, Velazquez Aurea Susana. "Nourriture palatable, gènes horloges et le circuit de la récompense." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ039.

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Cette thèse a étudié l’interaction entre l’obésité induit par la diète et la physiologie fcHFHS) avec un régime gras et sucrée ou un régime normocalorique chez la souris et le rat. Le régime fcHFHS a modifié le profile journalier de prise alimentaire et l’expression de la protéine PER2 dans l’habenula latérale (LHb) chez la souris. Cependant chez le rat, ni la prise alimentaire ni l’expression du gène Per2 dans la LHb n’ont changé, mais des altérations ont été observées dans le noyau accumbens. Chez les rats nourris avec une diète standard ou fcHFHS, le blocage glutamatergique dans la LHb indu
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3

Douglass, Amelia [Verfasser], and Rüdiger [Akademischer Betreuer] Klein. "Neural circuit mechanisms underlying modulation of food consumption and reward by the central amygdala / Amelia Douglass ; Betreuer: Rüdiger Klein." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/114827622X/34.

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4

Bermudez-Martin, Patricia. "Perturbations de la périphérie et du microbiote Intestinal dans les Troubles du Spectre Autistique : Le rôle spécifique du p-Crésol." Electronic Thesis or Diss., Université Côte d'Azur, 2020. http://www.theses.fr/2020COAZ6011.

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Ce travail de thèse porte principalement sur les anomalies périphériques associées aux Troubles du Spectre Autistique (TSA), un groupe de pathologies du neurodéveloppement fréquentes.La première section est consacrée au travail principal de ma thèse et porte sur l'influence du microbiote et des métabolites bactériens dans les TSA. Chez les patients autistes, les déficits d’interaction sociale et les comportements répétitifs ou stéréotypies sont fréquemment associés à des symptômes gastro-intestinaux, des anomalies de composition de la flore intestinale et des niveaux anormaux de métabolites pr
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5

Fiallos, Ana Marcia. "Brain circuits for the representation of subjective reward value." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62716.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, February 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 97-102).<br>Successful interaction with the external world requires choosing appropriate actions in the context of available choices. Such decisions require the evaluation of the reward magnitude, or value, associated with each potential action. Delineating the neural circuits involved in this process remains an important goal in systems neuroscience. However, little is known about the neural circuits t
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6

McHale, Gary. "Adaptive networks for robotics and the emergence of reward anticipatory circuits." Thesis, University of Sussex, 2012. http://sro.sussex.ac.uk/id/eprint/42409/.

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Currently the central challenge facing evolutionary robotics is to determine how best to extend the range and complexity of behaviour supported by evolved neural systems. Implicit in the work described in this thesis is the idea that this might best be achieved through devising neural circuits (tractable to evolutionary exploration) that exhibit complementary functional characteristics. We concentrate on two problem domains; locomotion and sequence learning. For locomotion we compare the use of GasNets and other adaptive networks. For sequence learning we introduce a novel connectionist model
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7

Ramirez, Donna Renee. "The neural circuitry of reward expectancies produced by the differential outcomes procedure." Diss., Online access via UMI:, 2006.

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8

Thurnham, A. J. "Computational modelling of the neural systems involved in schizophrenia." Thesis, University of Hertfordshire, 2008. http://hdl.handle.net/2299/1842.

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The aim of this thesis is to improve our understanding of the neural systems involved in schizophrenia by suggesting possible avenues for future computational modelling in an attempt to make sense of the vast number of studies relating to the symptoms and cognitive deficits relating to the disorder. This multidisciplinary research has covered three different levels of analysis: abnormalities in the microscopic brain structure, dopamine dysfunction at a neurochemical level, and interactions between cortical and subcortical brain areas, connected by cortico-basal ganglia circuit loops; and has c
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9

Thum, Andreas Stephan. "Sugar reward learning in Drosophila neuronal circuits in Drosophila associative olfactory learning /." Doctoral thesis, [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980586771.

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10

Chan, Ching-Yuen. "Cell controller for printed circuit board assembly rework." Thesis, University of Salford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386432.

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11

Rakotobé, Malalaniaina. "Bases neuro-développementales de la susceptibilité à l’anxiété : apports de l’étude du système habénulo-interpédonculaire." Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://www.theses.fr/2021COAZ6002.

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Les circuits de récompense du cerveau sont des réseaux neuronaux qui modulent positivement ou négativement la motivation à agir. Ils sont essentiels à la survie en sélectionnant les comportements adaptés à la situation, comme fuir les dangers ou rechercher de la nourriture. Leurs dysfonctionnements peuvent entraîner des troubles de l’humeur et des addictions. Bien que ces troubles psychiatriques se manifestent chez l’adulte, selon l’hypothèse neuro-développementale ils peuvent avoir une origine plus précoce. En effet, il existe des périodes particulières du développement appelées périodes crit
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12

Kucukdereli, Hakan [Verfasser], and Rüdiger [Akademischer Betreuer] Klein. "Functional mapping of central amygdala feeding and reward circuits / Hakan Kucukdereli ; Betreuer: Rüdiger Klein." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1148941258/34.

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13

Lefebvre, Germain. "Sélection d'un modèle d'apprentissage pour rendre compte de la spéculation dans un paradigme de prospection monétaire." Thesis, Paris 2, 2018. http://www.theses.fr/2018PA020010.

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Cette thèse de doctorat propose une analyse empirique des microfondations des phénomènes monétaires macroéconomiques, et plus particulièrement des processus d'apprentissage et capacités cognitives requis pour qu'un équilibre émerge dans une économie expérimentale implémentantun modèle de prospection monétaire. Dans ce but, nous avons "opérationalisé" le modèle original de Kiyotaki et Wright et modélisé le comportement de sujets humains à l'aide de différents algorithmes d'apprentissage par renforcement. Nous montrons que les données comportementales sont mieux expliquées par les modèles d'appr
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14

Awai, Alexandra F. "A functional MRI study of the distributed neural circuitry of learning and reward." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34457.

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Thesis (S.M. and S.B.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 2005.<br>Includes bibliographical references.<br>The aim of this research project was to study the neural substrates involved in processing rewarding stimuli. Evaluation of the magnitudes of reward is one of the fundamental aspects of goal directed behavior, and studies have shown that this process involves the midbrain dopamine system. Work by C. R. Gallistel has shown that the reward magnitude of electrical stimulation to structures within this system increases with increasing current and frequency.
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15

Sindi, Ghadir A. "Effects of Paternal Obesity on The Central Nervous System Reward Circuitry in Offspring." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470232740.

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16

Batten, Seth Richard. "MEASURING GLUTAMATE AND OXYGEN IN BRAIN REWARD CIRCUITS IN ANIMAL MODELS OF COCAINE ABUSE AND DECISION-MAKING." UKnowledge, 2019. https://uknowledge.uky.edu/psychology_etds/165.

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Drug-specific reward and associated effects on neural signaling are often studied between subjects, where one group self-administers drug and a separate group self-administers a natural reinforcer. However, exposure to drugs of abuse can cause long-term neural adaptations that can affect how an organism responds to drug reward, natural reward, and their reward-associated stimuli. Thus, to isolate drug-specific effects it is important to use models that expose the same organism to all of the aforementioned. Multiple schedules provide a means of dissociating the rewarding effects of a drug from
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17

Schreiter, Stefanie [Verfasser]. "Neural alterations of fronto-striatal circuitry during reward anticipation in euthymic bipolar disorder / Stefanie Schreiter." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/114076120X/34.

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18

Via, Virgili Esther. "Alterations in social reward and body perception brain circuits in anorexia nervosa: a functional and structural neuroimaging investigation." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/396283.

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Anorexia nervosa (AN) is a severe disorder, accepted to be of a multifactorial etiology. Although there is evidence for alterations in neural networks contributing to the onset, development and maintenance of AN, the knowledge of alterations of brain circuits is very limited. To this purpose, we investigated in three MRI experiments (two published, one in review) putative alterations in brain systems in a group of 20 female outpatients with AN, restrictive subtype, compared to a group at 20 female healthy controls. The first study aimed, in an exploratory manner, to find alterations in white m
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19

Geren, Necdet. "Design and development of the hardware for an automated PCBA inspection and rework cell." Thesis, University of Salford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386584.

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20

Nordenankar, Karin. "Functional Analysis of the Vesicular Glutamate Transporter 2 in Specific Neuronal Circuits of the Brain." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170046.

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A key issue in neuroscience is to determine the connection between neuronal circuits and behaviour. In the adult brain, all neuronal circuits include a glutamatergic component. Three proteins designated Vesicular glutamate transporter 1-3 (VGLUT1-3) possess the capability of packaging glutamate into presynaptic vesicles for release of glutamate at the nerve terminal. The present study aimed at determining the role of VGLUT2 in neuronal circuits of higher brain function, emotion, and reward-pocessing. A conditional knockout (cKO) strategy was utilised, and three different mouse lines were produ
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21

Majeed, Sulman. "Rework & reliability of area array components." Diss., Online access via UMI:, 2009.

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Thesis (M.S.)--State University of New York at Binghamton, Thomas J. Watson School of Engfineering and Applied Science, Department of Systems Science and Industrial Engineering, 2009.<br>Includes bibliographical references.
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22

Charbogne, Pauline. "Mu opioid receptors and neuronal circuits of addiction : genetic approaches in mice." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ030/document.

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Le récepteur opioïde mu est responsable des propriétés analgésiques et addictives puissantes de la morphine et de l’héroïne, mais son mode d’action à l’échelle des circuits neuronaux est mal connu et a été peu étudié par des approches génétiques. Le récepteur mu est largement exprimé dans le système nerveux, essentiellement dans des neurones GABAergiques. Le premier objectif de mon projet a été d’inactiver le gène codant pour le récepteur mu dans les neurones GABAergiques du cerveau antérieur et d’en étudier les conséquences comportementales. Notre étude montre que ces récepteurs ne sont pas i
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23

Pavlopoulos, Alexandros Ikaros. "Characterization of the synaptic connectivity patterns of genetically defined neuron types in circuits that regulate dopamine and serotonin." Thesis, KTH, Skolan för teknik och hälsa (STH), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-154201.

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The Lateral Habenula (LHb) have been implicated in both reward-seeking behavior and in depressive disorders due to its modulatory effects on dopamine rich areas. Excitatory projections from LHb target GABAergic interneurons of both ventral tegmental area (VTA) and rostromedial tegmental nucleus (RMTg) and consequently provide strong inhibition on VTA‟s dopaminergic neurons. These reward related signals are provided to LHb from distinct neuronal populations in internal Globus Pallidus (GPi). Here by using a dual viral combination of an adeno-associated helper virus (AAV) and a genetically modif
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24

García, Pérez Daniel. "Opiate addiction : neuronal plasticity on brain reward system and emotional memory-related areas = Adicción a opiáceos : plasticidad neuronal en los circuitos neuronales de recompensa y en áreas de memoria emocional." Doctoral thesis, Universidad de Murcia, 2015. http://hdl.handle.net/10803/327027.

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Tesis por compendio de publicaciones<br>Los opiáceos, como la morfina, son unos potentes analgésicos que se usan para tratar diversas formas de dolor agudo y crónico. Sin embargo, el uso crónico de opiáceos produce cambios neuroadaptativos a nivel cerebral que conllevan efectos indeseables, como la adicción. La creciente evidencia implica a varios mecanismos de regulación génica (incluyendo epigenéticos, moleculares, celulares y a nivel de circuitos neuronales) en los cambios que las drogas de abuso provocan en el cerebro, siendo el conocimiento de éstos una posible estrategia terapéutica para
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25

Berg, Junker Maria Constance. "Neural correlates of romantic love and romantic attachment." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16055.

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In the field of neuroscience, being in love and feeling romantically attached to a partner is described as a dynamic process. Romantic love may be viewed as a motivational system, changing throughout time and place, fluctuating on the interest and motivation of the individual. Early memories and attachment towards a caregiver, lay the foundation for later attachment behavior, also known as attachment styles. In this thesis, an exploratory approach is present. The thesis aims to introduce and describe the neural correlates of romantic love and romantic attachment. Brain regions concerned with r
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26

Krämer, Bernd [Verfasser], Oliver [Akademischer Betreuer] Gruber, Birgit [Gutachter] Kröner-Herwig, and Michael [Gutachter] Waldmann. "Fronto-striatal brain circuits involved in the pathophysiology of schizophrenia and affective disorders: FMRI studies of the effects of urbanicity and fearful faces on neural mechanisms of reward processing and self-control / Bernd Krämer ; Gutachter: Birgit Kröner-Herwig, Michael Waldmann ; Betreuer: Oliver Gruber." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://d-nb.info/1123283133/34.

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27

Huang, Kuan-Lun, and 黃冠倫. "A PLASTIC CORTICO-STRIATAL CIRCUIT MECHANISM FOR DYNAMIC NEURONAL AND BEHAVIORAL RESPONSES UNDER THE BIASED REWARD CONDITION." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/00278638307448419167.

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碩士<br>國立清華大學<br>系統神經科學研究所<br>98<br>Behavioral and neuronal activity can be influenced by reward information through dopamine-modulated synaptic plasticity. Recent primate experiments (Lauereyns, Watanabe, Hikosaka 2002) using biased saccade task (BST) have demonstrated that the activity of caudate nucleus (CD) neurons are stronger and the behavioral responses are faster when the target of a saccadic eye movement indicates a reward than when it does not. It has been suggested that the observation can be explained by the following mechanism: The co-activation of the pre- and post synaptic neuron
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28

Romeas, Thomas. "Changements dans le circuit de la récompense suite à la bulbectomie olfactive : une nouvelle approche pour étudier des antidépresseurs." Thèse, 2009. http://hdl.handle.net/1866/2975.

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La dépression est une maladie chronique, récurrente et potentiellement mortelle qui affecte plus de 20 % de la population à travers le monde. Les mécanismes sous-jacents de la dépression demeurent incompris et la pharmacothérapie actuelle, largement basée sur l’hypothèse monoaminergique, fait preuve d’une efficacité sous optimale et d’une latence thérapeutique élevée. Par conséquent, la recherche est amenée à élaborer de nouveaux traitements pharmacologiques. Pour détecter leur action, il est avant tout nécessaire de développer des outils expérimentaux adéquats. Dans cette optique, notre but a
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29

Kraushaar, Caroline. "Corrélats neuronaux du circuit des récompenses chez les jeunes à risque parental de troubles de l'humeur." Thèse, 2016. http://hdl.handle.net/1866/13972.

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Cette thèse a pour objectif l’investigation du circuit des récompenses, sur les plans comportementaux et neuronaux, chez des adolescents à risque parental élevé de dépression majeure et de trouble bipolaire, en comparaison à des jeunes à risque parental peu élevé. Plus précisément, le but est d’identifier des marqueurs comportementaux et neuronaux du risque de développer une dépression majeure ou un trouble bipolaire, afin d’être en mesure de détecter et de prévenir ces troubles le plus tôt possible pour éviter, ou du moins retarder, leur émergence. Pour ce faire, nous avons réalisé deux étude
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30

Cheng, Yu Chin, and 鄭宇晴. "Brain circuits for water reward memory in Drosophila." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/6f4fqd.

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31

Fulton, Stephanie E. "Functional heterogeneity in brain reward circuitry : characterization of a subpopulation of reward neurons linked to energy balance." Thesis, 2003. http://spectrum.library.concordia.ca/2297/1/NQ85260.pdf.

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The neural circuitry that gives rise to the rewarding effects of goal-objects and goal-directed behaviors can be directly studied with the use of brain stimulation reward (BSR). Brief trains of electrical stimulation to some brain regions produces a highly rewarding effect that rats will learn to self-administer. Stimulation of some sites in the lateral hypothalamus (LH) has been linked to the regulation of energy balance, supporting the notion that brain reward circuitry is subdivided along functional lines. Finding from the Master's thesis showed that the rewarding effect of the stimulation
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32

Chiu, Tai Hsiang, and 邱泰翔. "Identification of water-reward long-term memory consolidation circuits in thirsty Drosophila." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/qkjt5b.

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33

"Endomorphin circuitry in brain areas associated with pain and reward." Tulane University, 2003.

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The endomorphins are endogenous opioids with high affinity and selectivity for the mu opioid receptor (MOR). Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2 ,EM1) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2, EM2) have been localized to many regions of the central nervous system (CNS) including those that regulate antinociception and reward. Colocalization or overlap of two neurotransmitters in the same regions of the CNS may imply an interaction in the regulation of functions mediated in that region. For example, previous colocalization of EM2 with substance P (SP), calcitonin gene-related peptide (CGRP) and MO
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34

Smith, David Victor. "Neural Circuitry of Social Valuation." Diss., 2012. http://hdl.handle.net/10161/5590.

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<p>Few aspects of human cognition are more personal than the choices we make. Our decisions &mdash; from the mundane to the impossibly complex &mdash; continually shape the courses of our lives. In recent years, researchers have applied the tools of neuroscience to understand the mechanisms that underlie decision making, as part of the new discipline of decision neuroscience. A primary goal of this emerging field has been to identify the processes that underlie specific decision variables, including the value of rewards, the uncertainty associated with particular outcomes, and the consequences
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35

Tsai, Ya Lun, and 蔡亞倫. "Characterizing the circuits and molecules of water reward long-term memory in Drosophila brain." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/8f6gw9.

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36

Liu, Chien-Kai, and 劉劍剴. "Automatic Vision Placer for BGA Rework of SMT Circuit Board." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/74399056686705721557.

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碩士<br>輔仁大學<br>電機工程學系碩士班<br>101<br>The purpose of this study is to develop an automatic vision placer for BGA rework stations, to be used in maintaining or repairing BGAs in electronic devices, by calculating and comparing the PCB PADs with the BGA itself. This automatic system uses a CCD to capture color images, and performs image matching to find the center points for BGAs and PADs. This study first uses K-means clustering and binarization of circular pattern detection to reduce the parameter space, and applies the Hough Transform to identify all possible angles of a BGA and a PAD respective
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37

Thum, Andreas Stephan [Verfasser]. "Sugar reward learning in Drosophila : neuronal circuits in Drosophila associative olfactory learning / vorgelegt von Andreas Stephan Thum." 2006. http://d-nb.info/980586771/34.

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38

"Rewired retiming for flip-flop reduction and low power without delay penalty." 2009. http://library.cuhk.edu.hk/record=b5894017.

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Jiang, Mingqi.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2009.<br>Includes bibliographical references (leaves [49]-51).<br>Abstract also in Chinese.<br>Abstract --- p.i<br>Acknowledgement --- p.iii<br>Chapter 1 --- Introduction --- p.1<br>Chapter 2 --- Rewiring Background --- p.4<br>Chapter 2.1 --- REWIRE --- p.6<br>Chapter 2.2 --- GBAW --- p.7<br>Chapter 3 --- Retiming --- p.9<br>Chapter 3.1 --- Min-Clock Period Retiming --- p.9<br>Chapter 3.2 --- Min-Area Retiming --- p.17<br>Chapter 3.3 --- Retiming for Low Power --- p.18<br>Chapter 3.4 --- Retiming with Interconnect D
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39

Kaufman, Alexandra Mansell. "Non-canonical members of circuits: A role for the locus coeruleus in reward related place field plasticity, and investigating differences in astrocyte calcium signaling between hippocampal layers." Thesis, 2020. https://doi.org/10.7916/d8-xrc7-wy68.

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The hippocampus (HPC) is a brain area in the medial temporal lobe involved in spatial navigation, as well as the formation of episodic memories. A subset of the principal cells of the HPC, known as place cells, are active in specific locations of an environment, called the place fields. Dorsal hippocampal area CA1 contains place fields that are known to change their firing during spatial tasks where animals learn the location of a reward, known as goal-oriented learning (GOL) – CA1 place fields shift toward rewarded locations. Previous studies suggest that this preferentially occurs at novel r
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40

Chen, Wen-Kai, and 陳文愷. "The Influence of Intrinsic and Extrinsic Rewards on New Product Development Performance of Integrated Circuit Industry in Taiwan: The Moderating Effect of IT Support." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/79638857472209960456.

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碩士<br>國立臺北大學<br>企業管理學系<br>97<br>New product development is crucial to the success of high-technology companies. The performance of new product development is one important issue for management discipline. Rewards are usually used to foster performance of business activities, including new product development. IT support is usually treated as one essential element to business operation. This study conducted a mail questionnaire survey of the IC industry in Taiwan to examine the influence of intrinsic and extrinsic rewards on new product development performance and the moderating effect of IT su
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41

Krämer, Bernd. "Fronto-striatal brain circuits involved in the pathophysiology of schizophrenia and affective disorders: FMRI studies of the effects of urbanicity and fearful faces on neural mechanisms of reward processing and self-control." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-002B-7D01-A.

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