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Dissertations / Theses on the topic 'SciDB'

Author: Grafiati
Published: 9 September 2021
Last updated: 29 July 2025

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1

Anderson, Alan M. M. Eng Massachusetts Institute of Technology. "Remote data access and analysis using SciDB." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77076.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 63).<br>SciDB is an innovative data analysis system that provides fast querying and manipulation of large amounts of time-series, scientific data. This thesis describes the design of a framework that provides a user interface to SciDB that facilitates interactive processing of large datasets and supports long-running batch jobs on a remote server or cluster. Using this interface, python user scri
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2

Planthaber, Gary Lee Jr. "MODBASE : a SciDB-powered system for large-scale distributed storage and analysis of MODIS earth remote sensing data." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77035.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 80-81).<br>MODBASE, a collection of tools and practices built around the open source SciDB multidimensional data management and analytics software system, provides the Earth Science community with a powerful foundation for direct, ad-hoc analysis of large volumes of Level-1B data produced by the NASA Moderate Resolution Imaging Spectroradiometer (MODIS) instrument. This paper details the reasons
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3

Wang, Zhiyong. "Self-Calibrated Interferometric/Intensity Based Fiber Optic Temperature Sensors." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/9690.

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To fulfill the objective of providing robust and reliable fiber optic temperature sensors capable of operating in harsh environments, a novel type of fiber optic sensor system titled self-calibrated interferometric/intensity-based (SCIIB) fiber optic temperature sensor system is presented in this thesis including the detailed research work on the principle analysis, design, modeling, implementation and performance evaluation of the system. The SCIIB fiber optic temperature sensor system shows us an innovative fiber optic sensor system compared with traditional fiber optic sensors. In addition
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4

Macht, Lisa. "Human autoantibody production in SCID mice." Thesis, University of Bristol, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335368.

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5

Röther, Jens. "Die Rolle von Orai1 in der Entwicklung und Aktivierung von T- und B- Lymphozyten und die Bedeutung von Mutationen in Orai1 für die Pathogenese schwerer kombinierter Immundefekte." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-70949.

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Ein durch „Ca2+ Release Activated Ca2+ (CRAC)“-Kanal vermittelter Ca2+-Einstrom ist unverzichtbar für die vollständige Aktivierung von T-Zellen und eine produktive Immunantwort. Im Jahr 2006 führte die Entdeckung des transmembranen Proteins Orai1, einer porenbildenden Untereinheit des CRAC-Kanals, zu einem besseren Verständnis dieses Signalweges. Eine Mutation in Orai1 hat durch die Aufhebung der CRAC-Kanal Funktion eine schwere kombinierte Immundefizienz (SCID) zur Folge (Feske, S. et al. 2006). Die im Rahmen dieser Arbeit präsentierten Experimente hatten die nähere Erforschung der Rolle von
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6

Pennycook, Jacqueline Louise Mitchell Hamilton. "Analysis of endogenous immunoglobulin gene rearrangement in the SCID mouse." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ27711.pdf.

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7

Abdul-Razak, Hayder. "Correction of the classical scid mouse mutation by gene repair." Thesis, Royal Holloway, University of London, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588299.

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Gene addition strategies to correct inherited diseases are showing promise for treatment in the clinic, but an improved approach to treat both dominant and recessive genetic disorders would be to repair the mutant gene by homologous recombination-mediated gene targeting. Recently, gene targeting frequencies have dramatically increased through the development of (i) improved designer nuc1eases, including zinc finger nucleases (ZFN), able to introduce specific double-strand breaks at their target locus; and (ii) efficient DNA delivery tools, including integration-deficient lentiviral vectors (ID
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8

Motta, Fabiana Martins Batista. "A malaria experimental por Plasmodium chabaudi chabaudi em camundongo SCID." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317908.

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Orientador: Ana Maria Aparecida Guaraldo<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-03T22:32:49Z (GMT). No. of bitstreams: 1 Motta_FabianaMartinsBatista_M.pdf: 841034 bytes, checksum: 844c8cf19758150073cedaf1561d9483 (MD5) Previous issue date: 2003<br>Resumo: As células NK secretam as citoquinas INF-gama e TNF-alfa ¿ moléculas associadas com a resposta imune mediada por células do tipo Th1 ¿ em resposta a infecção por Plasmodium e ainda respondem à indução pela IL-12, conseguindo enfim, diminuir a mortalidade po
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9

Lowrey, Jacqueline Anne. "Transplantation of Hodgkin's and non-Hodgkin's lymphomas into SCID mice." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/20637.

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In an attempt to establish an <I>in vivo</I> animal model to study Hodgkin's disease (HD) and the histogenesis of the neoplastic cell of the disease - the Reed-Sternberg (RS) cell, and to study non-Hodgkin's lymphomas (NHL), severe combined immunodeficient (SCID) mice were transplanted with fresh biopsy material from 17 cases of HD and 25 cases of NHL. Five of the Hodgkin's (3 lymphocyte predominant, 1 nodular sclerosing and 1 mixed cellularity) and 7 of the non-Hodgkin's lymphomas (3 centroblastic, 1 immunoblastic, 1 follicular lymphoma and 2 biopsies from a case of B cell large cell anaplast
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10

Ahmed, Forhad. "Homing and engraftment of CD34+ cells in the NOD/SCID model." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445284/.

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The reduced engraftment potential of haemopoietic stem/progenitor cells after exposure to cytokines may be related to the impaired homing ability of actively cycling cells. I tested this hypothesis by quantifying the short-term homing of human adult CD34+ cells in NOD/SCID animals. I have demonstrated in adult CD34+ cells that cytokine exposure ex-vivo leads to a loss of engraftment ability in vivo which occurs rapidly and which is associated with a striking alteration in the tissue distribution of homed cells. Loss of homing to the BM and to a lesser extent, the spleen, coincides with increas
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11

Duez, Catherine. "La souris SCID humanisée : modèle d'étude de la réaction asthmatique allergique." Lille 1, 1997. http://www.theses.fr/1997LIL10218.

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L'asthme est une pathologie environnementale majeure touchant pres de 10% de la population mondiale. L'etude des mecanismes controlant la reaction allergique humaine conduisant aux manifestations cliniques observees est malheureusement encore limitee, malgre l'analyse de divers prelevements humains (biopsies, lavages bronchoalveolaires, etc) et l'utilisation de modeles animaux. Au cours de ce travail, nous avons developpe un modele d'etude de la reaction asthmatique allergique chez la souris scid humanisee (severe combined immunodeficiency). Nous avons montre que, seules des souris scid recons
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12

Assis, Ângela Maria de. "O papel das celulas linfoides de camundongos BALB/c normais e do anticorpo anti-T. cruzi em camundongos C.B-17 scid/scid infectados com o Trypanosoma cruzi." [s.n.], 1997. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316904.

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Orientador: Julia Keiko Sakurada<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-07-22T15:09:02Z (GMT). No. of bitstreams: 1 Assis_AngelaMariade_M.pdf: 2780125 bytes, checksum: ed0382f3c176db7f9c21e4d7373bbba3 (MD5) Previous issue date: 1997<br>Resumo: Para investigar a doença de Chagas experimental, camundongos BALB/c normais e C.B-17 scid/scid deficientes em linfócitos T e B funcionais foram inoculados com diferentes doses dos estoques tripomastigota de cultura (Tc) e tripomastigota sangüícola (Ts) da cêpa Y de Trypan
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13

Shaboodien, Gasna. "Characterization of the genetic defects in patients with Severe Combined Immunodeficiency (SCID)." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/11623.

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Bibliography: leaves 101-110.<br>A specialised clinic for the diagnosis of primary immunodeficiency diseases was established at the Red Cross War Memorial Children's Hospital (RXH) in 1982. The patient load was significant as clinic records indicated that 122 primary immunodeficiency cases were diagnosed on clinical and laboratory data in the period between 1983-1999. More than fifty percent of these conditions were antibody deficiency. Of the rest, nine cases were ascribed to severe combined immunodeficiency (SCID). The aim of the project was to do (1) mutational analysis on the affected fami
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14

Wagar, Eric James. "Human Lymphocyte Engraftment and Function in HU-PBL-SCID Mice: a Dissertation." eScholarship@UMMS, 2000. http://escholarship.umassmed.edu/gsbs_diss/286.

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The immune system is responsible for defending a host animal from a wide variety of threats. Manipulation of the immune system can result in beneficial outcomes such as immunity to pathogens, or deleterious outcomes such as autoimmunity. Advances in our understanding of how the immune system develops and functions have benefited greatly from studies in animals, particularly in mice where the genetics are well known and a multitude of reagents are readily available for experimental use. Although much has been learned from animal experimentation, it must be cautioned that animals are not humans.
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15

CARRIGLIO, NICOLA. "Preclinical gene therapy studies, altered lymphocyte development and function in ADA-SCID." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2012. http://hdl.handle.net/2108/209654.

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Genetic defects in the adenosine deaminase (ADA) gene are among the most common causes for severe combined immunodeficiency (SCID). ADA-SCID patients suffer from lymphopenia, absent cellular and humoral immunity, recurrent infections and autoimmune manifestations in milder forms. Currently available therapeutic options for this otherwise fatal disorder include bone marrow transplantation (BMT), enzyme replacement therapy with bovine ADA (PEG-ADA) or hematopoietic stem cell gene therapy (GT). The overall aims of my this thesis were to evaluate the preclinical safety of HSC gene therapy a
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16

Cavar, Marko. "Mutational Analysis of CD127 and Its Role in Immunological Diseases." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34404.

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Interleukin (IL) -7 is an essential non-redundant cytokine that influences T-cell differentiation, proliferation, homeostasis and T-cell functions. In T-cells, IL-7 signals are transduced via IL-7's heterodimeric receptor composed of a common, γ chain (CD132) and an IL-7 specific, α chain (CD127). In light of the many roles that IL-7 plays in T-cell biology, it is no surprise that CD127 expression is tightly regulated in T-cells. In this study, I explore the effects that disease specific mutations in CD127 have on CD127 expression, regulation and signal transduction using an in vitro T
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17

Abd, Hamid Intan Juliana. "Clinical, immunological and psycho-social outcome of SCID patients who underwent hematopoietic stem cell transplantation in Newcastle, UK, 1987-2012 and long-term outcome of the UK SCID cohort." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3803.

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Background - Severe Combined Immunodeficiencies (SCID) are primary immunodeficiencies with defective development and/or/function of T-lymphocyte, B-lymphocyte and Natural Killer cells. Hematopoietic stem cell transplantation (HSCT) corrects immunodeficiency but long-term impact of pre-HSCT chemotherapy, and immunoreconstitution are poorly documented. We explored: clinical outcome, immunoreconstitution, and quality of life (QoL) in SCID survivors >2 years post-HSCT (Newcastle cohort), newborn SCID (Newcastle cohort) and >20 years post-HSCT (Newcastle and London cohort). Methods A retrospective
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18

Hoviatdoost, Pejman. "Understanding mechanisms of change of Intensive Short Term Dynamic Psychotherapy." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/232623/1/Pejman_Hoviatdoost_Thesis.pdf.

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This program of research is the first to systematically evaluate a key process in Intensive Short Term Dynamic Psychotherapy (ISTDP). The study developed a new methodology for identifying unlocking and the findings suggest that "unlocking" and "defense restructuring" may represent mechanisms of change in ISTDP case studies. A series of case studies revealed the nuances of "unlocking" and "defense restructuring" in a clinical setting. The findings of this research increase the overall understanding of mechanisms of change in ISTDP, contributing to the current body of scientific research in the
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19

Thorn, Catherine Elisabeth. "Pasteurella haemolytica induced bronchopneumonia in Scid/bg mice, a model for bovine pneumonia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ31905.pdf.

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20

Kashofer, Karl. "Development potential of human haematopoietic stem cells in the NOD/Scid xenotransplantation model." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429937.

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21

Bouis, Delphine. "Etude des conséquences d’un gain de fonction de Sting chez la souris : modèle STING V154M/WT." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ063.

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Des mutations gains de fonction du gène STING chez l’Homme (telles que V155M) déclenchent une pathologie autoinflammatoire sévère de type interféronopathie, le SAVI (Sting associated vasculopathy with onset in infancy), une vasculopathie associée à une fibrose pulmonaire et des symptômes lupus-like. Afin de comprendre la physiopathologie du SAVI, nous avons généré un modèle murin porteur de la mutation correspondante grâce à la technologie CRISPR/Cas9. Ces souris STING V154M/WT développent un phénotype SCID (déficit immunitaire combiné sévère) avec diminution des LT, des LB et des NK en périph
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22

Lambert, K. Chad. "The effects of estrogen signaling in innate and adaptive immune cells /." Free to MU Campus, others may purchase, 2005. http://wwwlib.umi.com/cr/mo/fullcit?p3189934.

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23

Rohn, Gerhard. "Transfer der humanen inflammatorischen Kardiomyopathie in die SCID-Maus immunologische und hämodynamische Evaluierung der Tiere /." [S.l.] : [s.n.], 2003. http://www.diss.fu-berlin.de/2003/301/index.html.

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24

Hoya, Vivian [Verfasser], Nikolas [Gutachter] Stoecklein та Wolfgang [Gutachter] Schulz. "Xenotransplantation humaner Ösophaguskarzinomzelllinien in NOD/SCID IL2Rγnull - Mäuse / Vivian Hoya ; Gutachter: Nikolas Stoecklein, Wolfgang Schulz". Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1184017387/34.

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25

Alves, Delma Pegolo. "Trypanosoma cruzi : a influencia dos linfocitos T na regulação da infecção experimental em camungongo SCID." [s.n.], 1998. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316905.

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Orientador: Julia Keiko Sakurada<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-07-24T17:50:34Z (GMT). No. of bitstreams: 1 Alves_DelmaPegolo_M.pdf: 2384507 bytes, checksum: c51a6c07f4248e1558d20662c49bc7f1 (MD5) Previous issue date: 1998<br>Resumo: Experimentos realizados por ASSIS (1997), com camundongos scm mostraram que, a susceptibilidade desse animal ao Trypanosoma cruzi, era revertida através da repopulação com as células esplênicas da linhagem congênica BALB/c, e que os anticorpos anti- T cruzi transferidos pas
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26

Shriner, Anne K. "Analysis of the Human Variable Gene Repertoire in Response to Pneumococcal Polysaccharides." University of Toledo Health Science Campus / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=mco1174573682.

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27

Dhala, Ruwaida. "An analysis of the in vivo SEB response in a T cell receptor scid transgenic mouse." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29257.pdf.

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28

Vesprini, Danny. "Illegitimate V(D)J rearrangement in ã-irradiation induced T cell lymphoma in newborn scid mice." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29263.pdf.

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29

Hörrmann, Reinhard [Verfasser], and P. J. [Akademischer Betreuer] Lang. "Charakterisierung leukämischer Progenitorzellen im NOD/SCID-Mausmodell mittels Hoechst 33342 / Reinhard Hörrmann ; Betreuer: P. J. Lang." Tübingen : Universitätsbibliothek Tübingen, 2013. http://d-nb.info/1160601763/34.

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30

GRANDADAN, MARC. "Etude virologique des infections experimentales a vih-1 et hhv-8 chez la souris scid humanisee." Paris 7, 1999. http://www.theses.fr/1999PA077103.

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Nous avons utilise des modeles de souris scid pour etudier les aspects virologiques des infections par le virus de l'immunodeficience humaine de type 1 (vih-1) et de l'herpesvirus humain 8 (hhv-8). Dans un premier temps, nous avons mis au point et optimise un modele d'implantation de thymus et de poumon sur souris scid. L'inoculation d'isolats primaires par voie intraperitoneale entrainait une infection bifocale dont la frequence dependait de la dose de virus inoculee. Des techniques d'hybridation in situ et et d'immuno-histochimie ont permis d'identifier les cellules infectees par le vih-1 da
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31

Provençal, Philippe. "Étude de biomarqueurs pour la maladie de Fabry dans les tissus de souris NOD/SCID/Fabry." Mémoire, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/10972.

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La maladie de Fabry est une maladie lysosomale présentant une grande hétérogénéité phénotypique et génotypique. Elle est causée par des mutations au niveau du gène GLA, situé sur le chromosome X, entrainant un déficit de l'enzyme alpha-galactosidase A. Celui-ci mène à une accumulation de globotriaosylcéramide (Gb3), de globotriaosylsphingosine (lyso-Gb3) et de galabiosylcéramide (Ga2) et leurs isoformes et analogues respectifs qui sont utilisés comme biomarqueurs pour la maladie de Fabry. Il est possible de les quantifier dans les liquides biologiques tels que le plasma et l’urine des patients
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Guptill, Virginia Anne. "The role of neural cell adhesion molecule in the tumorigenicity of multiple myeloma in SCID mice." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186819.

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Neural Cell Adhesion Molecule (NCAM) is a glycoprotein involved in cell adhesion. NCAM is present on multiple myeloma (MM) as determined by immunohistochemistry. Molecular characterization of MM associated NCAM determined that MM expresses the 140 kd form of the molecule and the sequence of a 525bp RT-PCR product is identical to lymphoid associated forms of the molecule. The 8226 Dox40 cell line is 50% positive for NCAM. This cell line was sorted and subsequently cloned into an NCAM negative and NCAM positive population. To determine what role NCAM plays in the pathogenesis of MM SCID mice wer
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33

Bürkle, Carl-Philipp Stavros. "Die Expression antimikrobieller Peptide (Psoriasin, HBD-2 und HBD-3) in menschlicher Haut und deren Modulation in vivo - eine Untersuchung im xenogenen Haut-Transplantationsmodell." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-73827.

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In der humanen Haut spielen antimikrobielle Peptide (AP) bei Entzündungsgeschehen bakteriellen und nicht-bakteriellen Ursprungs eine bedeutende Rolle. Neben einer konstitutiven Expression AP können Zytokine deren vermehrte oder abgeschwächte Expression bewirken. In dieser Arbeit wurden die AP humanes β-Defensin (HBD) -2, HBD-3 und Psoriasin (PSO) in Bezug auf deren Expression in gesunder Haut und deren Modulation durch Zytokine in vivo anhand des xenogenen NOD-SCID-Maus-Transplantationsmodells untersucht. Nach erfolgreicher Transplantation von humaner Haut auf NOD-SCID Mäuse wurden die Zytokin
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Walic, Marine. "Rôle des lipoprotéines associées au virus de l'hépatite C et des microtubules dans l'entrée du virus dans la cellule et l'établissement de l'infection." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2010. http://tel.archives-ouvertes.fr/tel-00814990.

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L'hépatite C reste un problème majeur de santé publique. Malgré la mise au point d'un modèle de réplication du virus de l'hépatite C (VHC) in vitro, les mécanismes conduisant à l'infection restent encore mal connus. Le VHC est sécrété et circule dans le sérum associé à des lipoprotéines. L'importance des lipoprotéines pour le cycle viral nous a conduits à étudier le rôle de la lipoprotéine lipase (LPL), une enzyme lipolytique, dans l'infection de la cellule par le VHC. Nous avons montré que la LPL potentialise l'attachement et l'internalisation du virus par un mécanisme similaire à la clearanc
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35

Ehm, Astrid Michaela Verfasser], and Udo [Akademischer Betreuer] [Schumacher. "Wirkung von Mistellektin-I im Extrakt Iscador M 5 mg spezial auf das Wachstums- und Metastasierungsverhalten der humanen Melanomzelllinie MV3 in vivo in einem Scid- und E-/-, P-/-, Scid-Maus-Xenograftmodell / Astrid Michaela Ehm. Betreuer: Udo Schumacher." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2011. http://d-nb.info/102038462X/34.

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Christou, Niki. "De la caractérisation des Cellules Initiant le Cancer Colorectal vers un biomarqueur pronostique et de surveillance des sujets traités pour cancer colorectal." Thesis, Limoges, 2017. http://www.theses.fr/2017LIMO0007.

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Le Cancer Colo Rectal (CCR) est la deuxième cause de mortalité par cancer dans le monde. Le risque de récidive après traitement curatif atteint 45% pour les stades 3. Une des hypothèses à l’heure actuelle pouvant expliciter le processus métastatique et les récidives est la présence en son sein de cellules « souches », pouvant « initier » le cancer. Notre réflexion s’inscrit dans la continuité des travaux réalisés au sein de notre Laboratoire, intitulés «Stratégies d’isolement et de caractérisation des cellules initiatrices de cancer colorectal», (Mélin et al, 2012). Dans une première partie, n
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Brown, Vinette B. "Adoptive transfer studies to establish a model of phase ii exocrine gland dysfunction in the nod model of sjogren's syndrome." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0007027.

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Thesis (M.S.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 62 pages. Includes Vita. Includes bibliographical references.
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Bodlund, Owe. "Transsexualism and personality : methodological and clinical studies on gender identity disorders." Doctoral thesis, Umeå universitet, Psykiatri, 1994. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100587.

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Patients suffering from transsexualism (TS) who apply for sex reassignment surgery (SRS) go through a complex evaluation process before being accepted for treatment. In general, the results from SRS are satisfying. However, further knowledge is needed to clearly delineate transsexualism from other related gender identity disorders (GID) and to improve the selection of candidates for SRS. Personality has for a long time been considered as the key concept for that purpose but systematic studies using reliable instruments are lacking. The present study aims at improving the assessment procedure,
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Walterman, Sarah K. "Genetic Testing Practices of Physicians for Primary Immunodeficiency Diseases." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396532728.

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40

Larochelle, André. "Identification and characterization of human hematopoietic stem cells using gene transfer and the novel SCID transplantation assay." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0012/NQ27987.pdf.

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Deutsch, Marcus-André. "Charakterisierung des kardioregenerativen Potenzials adulter humaner endothelialer Progenitorzellen vom Typ ECFC im Infarktmodell der SCID/Beige-Maus." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-176478.

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Akute und chronische Myokardischämien ziehen einen irreversiblen Verlust an funktionellem Myokard nach sich und sind mit weitreichenden strukturellen Umbauprozessen am verbleibenden Myokard assoziiert. Häufig entwickelt sich eine progrediente Herzinsuffizienz. Aus Ermangelung an kurativen Behandlungsmöglichkeiten, der schlechten Prognose sowie der immensen sozioökonomischen Bedeutung leitet sich die dringliche Notwendigkeit für die Entwicklung neuer, alternativer Therapiestrategien ab. Vielversprechend erscheint das innovative therapeutische Konzept der zellbasierten myokardialen Regeneration,
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42

Zubair, Abba Chedi. "Evaluation of the SCID mouse as a model system for in-vivo studies of non-Hodgkin's lymphomas." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364290.

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43

Santos, Fernanda Araujo dos. "Xenotransplante ovariano de gatas domésticas em camundongas C57BL/6 SCID e sua resposta á gonadotrofina coriõnica equina." Universidade Federal Rural do Semi-Árido, 2015. http://bdtd.ufersa.edu.br:80/tede/handle/tede/382.

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Made available in DSpace on 2016-08-15T20:31:29Z (GMT). No. of bitstreams: 1 FernandaAS_DISSERT.pdf: 1414995 bytes, checksum: e7e006bb87888d5b4777f2f259d7afd8 (MD5) Previous issue date: 2015-09-29<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Ovarian xenografting is an auxiliary reproductive technique that allows the conservation of germplasm of high value livestock or endangered species. The use of exogenous gonadotropins assists in developing these xenografted tissues and obtaining viable follicles for in vitro embryo production (IVEP), however this use has not been rep
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44

Robin, Catherine. "Identification chez l'homme de cellules souches totipotentes lympho-myeloides transplantables in vivo dans un modele nod-scid." Paris 7, 2000. http://www.theses.fr/2000PA077205.

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L'etude des cellules souches hematopoietiques (csh) a ete freinee pendant longtemps par l'absence de conditions experimentales appropriees a l'identification de tous les potentiels de differenciation lympho-myeloide de cellules primitives a l'echelon clonal. Dans ce travail, nous avons montre que la descendance lymphoide (t, b, nk) et myeloide (granulo-macrophagique) de cellules humaines de sang de cordon peut etre identifiee simultanement in vitro. Les potentiels myeloides, lymphoides b et nk ont ete testes dans un meme systeme de culture en presence de cellules stromales murines (ms-5) et de
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Bainczyk, Katja. "Entwicklung eines in vivo-Modells in der Nacktmaus und der NOD-SCID-Maus zur Untersuchung der humanen Endometriose." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=961854596.

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Kogan, Ilana. "An in vivo model for PSA production by breast cancer cell-lines growing as xenografts in scid mice." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29268.pdf.

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Nguyen, Hai Phu. "Combination of hu-PBL-SCID mice and scFv phage display library, an effective alternative for hu-mAb production." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58617.pdf.

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Whiting, Christine Vivienne. "Transforming growth factor β in the SCID mouse model of colitis : a complex cytokine in a complex disease." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251136.

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Hiramatsu, Hidefumi. "Complete reconstitution of human lymphocytes from cord blood CD34[+] cells using the NOD/SCID/γc null mice model". Kyoto University, 2003. http://hdl.handle.net/2433/148475.

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FIRRITO, CLAUDIA. "Targeted Gene Correction and Reprogramming of SCID-X1 Fibroblasts to Rescue IL2RG Expression in iPSC-derived Hematopoietic Cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/94656.

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La terapia genica basata sull’utilizzo di vettori integranti è stata già applicata con successo per la cura di varie malattie genetiche come le malattie da accumulo lisosomiale (LSD), la beta-talassemia (β-Thal) e le immunodeficienze primarie (PID). L’immunodeficienza combinata grave legata al cromosoma X (SCID-X1) è una malattia monogenica letale causata da mutazioni del gene codificante la catena comune gamma del recettore per l’interleuchina 2 (IL2RG). I primi studi clinici per la SCID-X1 hanno mostrato il potenziale terapeutico della terapia genica basata su vettori integranti, risultando
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