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Journal articles on the topic 'SciDB'

Author: Grafiati

Published: 9 September 2021

Last updated: 29 July 2025

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1

Cudre-Mauroux, P., H. Kimura, K. T. Lim, et al. "A demonstration of SciDB." Proceedings of the VLDB Endowment 2, no. 2 (2009): 1534–37. http://dx.doi.org/10.14778/1687553.1687584.

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2

Gerhardt, L., C. H. Faham, and Y. Yao. "Accelerating Scientific Analysis with SciDB." Journal of Physics: Conference Series 664, no. 7 (2015): 072019. http://dx.doi.org/10.1088/1742-6596/664/7/072019.

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3

Becla, Jacek, and Kian-Tat Lim. "Report from the SciDB Workshop." Data Science Journal 7 (2008): 88–95. http://dx.doi.org/10.2481/dsj.7.88.

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4

Joshi, A., E. Pebesma, R. Henriques, and M. Appel. "SCIDB BASED FRAMEWORK FOR STORAGE AND ANALYSIS OF REMOTE SENSING BIG DATA." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-5/W3 (December 5, 2019): 43–47. http://dx.doi.org/10.5194/isprs-archives-xlii-5-w3-43-2019.

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Abstract. Earth observation data of large part of the world is available at different temporal, spectral and spatial resolution. These data can be termed as big data as they fulfil the criteria of 3 Vs of big data: Volume, Velocity and Variety. The size of image in archives are multiple petabyte size, the size is growing continuously and the data have varied resolution and usages. These big data have variety of applications including climate change study, forestry application, agricultural application and urban planning. However, these big data also possess challenge of data storage, managemen

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5

Stonebraker, Michael, Paul Brown, Donghui Zhang, and Jacek Becla. "SciDB: A Database Management System for Applications with Complex Analytics." Computing in Science & Engineering 15, no. 3 (2013): 54–62. http://dx.doi.org/10.1109/mcse.2013.19.

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6

Yao, Yushu, Benjamin P. Bowen, Dalya Baron, and Dovi Poznanski. "SciDB for High-Performance Array-Structured Science Data at NERSC." Computing in Science & Engineering 17, no. 3 (2015): 44–52. http://dx.doi.org/10.1109/mcse.2015.43.

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7

Liu, Haicheng, and Xiao Xiao. "Comparing NetCDF and SciDB on managing and querying 5D hydrologic dataset." IOP Conference Series: Earth and Environmental Science 46 (November 2016): 012031. http://dx.doi.org/10.1088/1755-1315/46/1/012031.

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8

Liu, Haicheng, Peter van Oosterom, Theo Tijssen, Tom Commandeur, and Wen Wang. "Managing large multidimensional hydrologic datasets: A case study comparing NetCDF and SciDB." Journal of Hydroinformatics 20, no. 5 (2018): 1058–70. http://dx.doi.org/10.2166/hydro.2018.136.

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Abstract Management of large hydrologic datasets including storage, structuring, clustering, indexing, and query is one of the crucial challenges in the era of big data. This research originates from a specific problem: time series extraction at specific locations takes a long time when a large multidimensional (MD) dataset is stored in the NetCDF classic or the 64-bit offset format. The essence of this issue lies in the contiguous storage structure adopted by NetCDF. In this research, NetCDF file-based solutions and a MD array database management system applying a chunked storage structure ar

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9

Liu, Haicheng, Peter van Oosterom, Chengfang Hu, and Wen Wang. "Managing Large Multidimensional Array Hydrologic Datasets: A Case Study Comparing NetCDF and SciDB." Procedia Engineering 154 (2016): 207–14. http://dx.doi.org/10.1016/j.proeng.2016.07.449.

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10

Malon, D., J. Cranshaw, P. van Gemmeren, and Q. Zhang. "Emerging Database Technologies and Their Applicability to High Energy Physics: A First Look at SciDB." Journal of Physics: Conference Series 331, no. 4 (2011): 042016. http://dx.doi.org/10.1088/1742-6596/331/4/042016.

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11

Porto, Fabio, Ramon G. Costa, Ana Maria de C. Moura, and Bernardo Gonçalves. "Modeling and Implementing Scientific Hypothesis." Journal of Database Management 26, no. 2 (2015): 1–13. http://dx.doi.org/10.4018/jdm.2015040101.

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Computational Simulations are important tools that enable scientists to study complex phenomena about which few data is available or that require dangerous human interventions. They involve complex and heterogeneous components, including: mathematical equations, hypothesis, computational models and data. In order to support in-silico scientific research this complex environment needs to be modeled and have its data and metadata managed enabling model evolution, prediction analysis and decision-making. This paper proposes a scientific hypothesis conceptual model that allows scientists to repres

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12

Malon, D., P. van Gemmeren, and J. Weinstein. "An exploration of SciDB in the context of emerging technologies for data stores in particle physics and cosmology." Journal of Physics: Conference Series 368 (June 21, 2012): 012021. http://dx.doi.org/10.1088/1742-6596/368/1/012021.

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13

Appel, Marius, Florian Lahn, Wouter Buytaert, and Edzer Pebesma. "Open and scalable analytics of large Earth observation datasets: From scenes to multidimensional arrays using SciDB and GDAL." ISPRS Journal of Photogrammetry and Remote Sensing 138 (April 2018): 47–56. http://dx.doi.org/10.1016/j.isprsjprs.2018.01.014.

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14

Kawai, Yusuke, Jing Zhao, Kento Sugiura, Yoshiharu Ishikawa, and Yukiko Wakita. "An Analysis Technique of Evacuation Simulation Using an Array DBMS." Journal of Disaster Research 13, no. 2 (2018): 338–46. http://dx.doi.org/10.20965/jdr.2018.p0338.

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Today, large-scale simulations are thriving because of the increase of computating performance and storage capacity. Understanding the results of these simulations is not easy, and hence, support for interactive and exploratory analysis is becoming more important. This study focuses on spatio-temporal simulations and attempts to develop an analysis technology to support them. It uses a database system for supporting interactive analysis of large-scale data. Since the data gained via spatio-temporal simulations is not suitable for management in a relational DBMS (RDBMS), this study uses an arra

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15

Han, S., J. Han, Y. Choi, S. Lee, M. Kim, and S. Lee. "DEVELOPMENT OF A MULTI-DIMENSIONAL ARRAY DATABASE BASED MASSIVE SATELLITE INFORMATION PROCESSING AND ANALYSIS SYSTEM: KIWI-SAT." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVIII-4/W1-2022 (August 5, 2022): 181–86. http://dx.doi.org/10.5194/isprs-archives-xlviii-4-w1-2022-181-2022.

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Abstract. Information and communication technology (ICT) is mainly applied to finance, telecommunications, and public sectors. However, since the early 2010s, there have been efforts to apply ICT to various fields such as aerospace, life science, energy, and automobiles. Recently, artificial intelligence and big data technologies have also been applied in the aerospace field, among others. In the field of aerospace, earth observation attracts the most interest.One reason earth observation attracts such interest is that the availability of a satellite constellation allows more frequent observat

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16

Takeuchi, Dan, Vickie C. Jones, Makiko Kobayashi, and Fujio Suzuki. "Cooperative Role of Macrophages and Neutrophils in Host Antiprotozoan Resistance in Mice Acutely Infected with Cryptosporidium parvum." Infection and Immunity 76, no. 8 (2008): 3657–63. http://dx.doi.org/10.1128/iai.00112-08.

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ABSTRACT Severe experimental infections with Cryptosporidium parvum have been reported in immunocompromised animals such as SCID mice (mice without functional T cells and B cells). In a C. parvum infection with 1 × 106 oocysts/mouse in SCID beige (SCIDbg) mice (SCID mice lacking functional NK cells), oocyst shedding was first demonstrated 18 days after infection. However, shedding was shown as early as 3 days after the same infection in SCIDbgMN mice. All of the SCIDbgMN mice died within 16 days of C. parvum infection, while 100% of the SCIDbg mice exposed to the parasite survived. SCIDbgMN mi

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17

Mishchenko, A. Yu, Yu V. Petrova, N. V. Davydova, A. M. Kiyeva, and N. V. Zinovyeva. "CLINICAL CASE OF BARE LYMPHOCYTE SYNDROME." Pediatria. Journal named after G.N. Speransky 103, no. 3 (2024): 171–77. http://dx.doi.org/10.24110/0031-403x-2024-103-3-171-177.

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Article represents a clinical case of severe combined immune deficiency (SCID), deficiency of MHC class II molecules which was coupled with normal levels of TREC and KREC in a pediatric patient. Simultaneous determination of TREC and KREC in dried blood spots during neonatal screening makes it possible to diagnose various forms of congenital immunodeficiency disorders. For example, a dramatic decrease in TREC is observed in most SCIDs and combined immune deficiencies. However, in some SCIDs associated with a defect primarily in T-cell function rather than T-cell differentiation, TREC levels do

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18

Andoh, Masako, Guoquan Zhang, Kasi E. Russell-Lodrigue, Heather R. Shive, Brad R. Weeks, and James E. Samuel. "T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice." Infection and Immunity 75, no. 7 (2007): 3245–55. http://dx.doi.org/10.1128/iai.01767-06.

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ABSTRACT Coxiella burnetii, the etiological agent of Q fever, has two phase variants. Phase I has a complete lipopolysaccharide (LPS), is highly virulent, and causes Q fever in humans and pathology in experimental animals. Phase II lacks an LPS O side chain, is avirulent, and does not grow well in immunocompetent animals. To understand the pathogenicity of Q fever, we investigated the roles of immune components in animals infected with Nine Mile phase I (NM I) or Nine Mile phase II (NM II) bacteria. Immunodeficient mice, including SCID mice (deficient in T and B cells), SCIDbg mice (deficient

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19

MacDonald, Andrew. "PhilDB: the time series database with built-in change logging." PeerJ Computer Science 2 (March 30, 2016): e52. http://dx.doi.org/10.7717/peerj-cs.52.

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PhilDB is an open-source time series database that supports storage of time series datasets that are dynamic; that is, it records updates to existing values in a log as they occur. PhilDB eases loading of data for the user by utilising an intelligent data write method. It preserves existing values during updates and abstracts the update complexity required to achieve logging of data value changes. It implements fast reads to make it practical to select data for analysis. Recent open-source systems have been developed to indefinitely store long-period high-resolution time series data without ch

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20

Thornhill, Susannah I., and Adrian J. Thrasher. "Success and risk: Gene therapy for severe combined immunodeficiency." Biochemist 30, no. 3 (2008): 26–29. http://dx.doi.org/10.1042/bio03003026.

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SCIDs are a group of inherited disorders characterized by profound defects in both cellmediated and humoral immunity (Figure 1). These diseases represent the most severe forms of primary immunodeficiencies, affecting approximately 1 child in every 75000 livebirths. The molecular pathology of these disorders has been deter mined for the majority of cases (Table 1), which typi cally present in the first few months of life with failure to thrive, chronic diarrhoea and recurrent infections. Conventional treatment for SCID is HSCT (haemo poietic stem cell transplantation) with high longterm surviva

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21

Lagresle-Peyrou, Chantal, Aurélien Olichon, Hanem Sadek, et al. "An Autosomal Dominant SCID Form Due to a Gain of Function Mutation in the RAC2 Gene." Blood 134, Supplement_1 (2019): 3742. http://dx.doi.org/10.1182/blood-2019-126855.

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Severe combined immunodeficiencies (SCIDs) form a heterogeneous group of life-threatening genetic disorders defined by the absence of autologous T cells and an intrinsic or extrinsic defect in the B-cell compartment. In our cohort, three newborn patients with bone-marrow hypoplasia associated with clinical and biological features of SCID received allogenic hematopoietic stem cell transplantation in the first weeks of life. To identify the molecular defect involved in this life threatening SCID form, we performed whole-genome sequencing on patient's fibroblasts. The same heterozygous, dominant

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22

Albert, S. E., C. McKerlie, A. Pester, et al. "Time-dependent induction of protective anti-influenza immune responses in human peripheral blood lymphocyte/SCID mice." Journal of Immunology 159, no. 3 (1997): 1393–403. http://dx.doi.org/10.4049/jimmunol.159.3.1393.

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Abstract The human (hu) PBL/SCID mouse model has the potential to provide a powerful tool for the study of human immune function. However, at peak engraftment (4-8 wk postinjection), recovered human T cells are largely unresponsive to foreign Ag and have converted to an activated/memory-type phenotype. Here we show that this conversion is not a prerequisite for engraftment because at early stages (2 wk) a substantial fraction of human T cells detected in SCID peripheral blood retains the unactivated/naive phenotype of donor PBL. This early stage is also associated with a TCR repertoire in both

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23

ARCHIVIST. "SCIDA." Archives of Disease in Childhood 82, no. 1 (2000): 37. http://dx.doi.org/10.1136/adc.82.1.37.

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24

Buckley, Rebecca H. "SCID." North Carolina Medical Journal 80, no. 1 (2019): 55–56. http://dx.doi.org/10.18043/ncm.80.1.55.

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25

Johnston, Richard B. "SCID." JAMA 296, no. 4 (2006): 450. http://dx.doi.org/10.1001/jama.296.4.453.

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26

Long, Sarah S. "SCID without typical SCID immunologic abnormalities." Journal of Pediatrics 147, no. 4 (2005): A2. http://dx.doi.org/10.1016/j.jpeds.2005.09.009.

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27

Diana, Jean-Sebastien, Naim Bouazza, Chloé Couzin, et al. "Modeling of Immune Reconstitution Post CD34 Selected Stem Cell Transplantation in Pediatric Patients with Severe Combined Immune Deficiency." Blood 134, Supplement_1 (2019): 5668. http://dx.doi.org/10.1182/blood-2019-127974.

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Severe combined immunodeficiencies (SCID) are a heterogeneous group of inherited disorders characterized by a profound reduction or alteration of T lymphocyte function. They arise from a variety of molecular defects which affect T lymphocytes development and function. The number of infections prior hematopietic stem cells tansplantaton (HSCT), genotype, and the type of donor are described as prognostic factors for stem cell transplants. In this retrospective study, we included 30 pediatric patients suffering from SCID who underwent to CD34+-selected grafts between January 2008 to December 2017

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28

HIYAMA, Masato, Ken Takeshi KUSAKABE, Ai KUWAHARA, Shoichi WAKITANI, Hamayun KHAN, and Yasuo KISO. "Differentiation of Uterine Natural Killer Cells in Pregnant SCID (scid/scid) Mice." Journal of Veterinary Medical Science 73, no. 10 (2011): 1337–40. http://dx.doi.org/10.1292/jvms.11-0189.

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29

Kohn, Donald B. "Eliminating SCID row: new approaches to SCID." Hematology 2014, no. 1 (2014): 475–80. http://dx.doi.org/10.1182/asheducation-2014.1.475.

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Abstract Treatments for patients with SCID by hematopoietic stem cell transplantation (HSCT) have changed this otherwise lethal primary immune deficiency disorder into one with an increasingly good prognosis. SCID has been the paradigm disorder supporting many key advances in the field of HSCT, with first-in-human successes with matched sibling, haploidentical, and matched unrelated donor allogeneic transplantations. Nevertheless, the optimal approaches for HSCT are still being defined, including determining the optimal stem cell sources, the use and types of pretransplantation conditioning, a

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30

MOSIER, DONALD E., RICHARD J. GULIZIA, STEPHEN M. BAIRD, and DARCY B. WILSON. "On the SCIDs?" Nature 338, no. 6212 (1989): 211. http://dx.doi.org/10.1038/338211b0.

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31

MOSIER, DONALD E., RICHARD J. GULIZIA, BRUCE E. TORBETT, STEPHEN M. BAIRD, and DARCY B. WILSON. "Break for SCIDs." Nature 353, no. 6344 (1991): 509. http://dx.doi.org/10.1038/353509c0.

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32

Zarr, Michael L. "Mini-SCID." American Journal of Psychotherapy 47, no. 1 (1993): 159–60. http://dx.doi.org/10.1176/appi.psychotherapy.1993.47.1.159.

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33

Roopenian, Derry C., and Paul S. Anderson. "ADOPTIVE IMMUNITY IN IMMUNE-DEFICIENT scid/scid MICE." Transplantation 46, no. 6 (1988): 899–904. http://dx.doi.org/10.1097/00007890-198812000-00021.

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34

HARKNESS, ROBIN E., MARIE-JOSÉE GUIMOND, BETTY-ANNE McBEY, MICHEL H. KLEIN, DEAN H. PERCY, and B. ANNE CROY. "Branhamella catarrhalispathogenesis in SCID and SCID/beige mice." APMIS 101, no. 7-12 (1993): 805–10. http://dx.doi.org/10.1111/j.1699-0463.1993.tb00184.x.

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35

Bloomfield, Markéta, Adam Klocperk, and Anna Šedivá. "Newborn screening of sborn errors of immunity - SCID screening." Pediatrie pro praxi 25, no. 5 (2024): 315–16. http://dx.doi.org/10.36290/ped.2024.060.

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36

YOSHIZAWA, Miki, Toshiya OKADA, Yoshio MORIKAWA, Fumihiko SASAKI, and Yasuo KISO. "Murine Granulated Metrial Gland Cell Population in Beige (bg/bg) and SCID (scid/scid) Genotypes." Journal of Veterinary Medical Science 56, no. 2 (1994): 415–16. http://dx.doi.org/10.1292/jvms.56.415.

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37

Shultz, L. D., P. A. Schweitzer, S. W. Christianson, et al. "Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice." Journal of Immunology 154, no. 1 (1995): 180–91. http://dx.doi.org/10.4049/jimmunol.154.1.180.

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Abstract The scid mutation was backcrossed ten generations onto the NOD/Lt strain background, resulting in an immunodeficient stock (NOD/LtSz-scid/scid) with multiple defects in adaptive as well as nonadaptive immunologic function. NOD/LtSz-scid/scid mice lack functional lymphoid cells and show little or no serum Ig with age. Although NOD/(Lt-)+/+ mice develop T cell-mediated autoimmune, insulin-dependent diabetes mellitus, NOD/LtSz-scid/scid mice are both insulitis- and diabetes-free throughout life. However, because of a high incidence of thymic lymphomas, the mean lifespan of this congenic

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38

Leber, Ray, Rhonda Wilera, Lance E. Perryman, and Katheryn Meek. "Equine SCID: mechanistic analysis and comparison with murine SCID." Veterinary Immunology and Immunopathology 65, no. 1 (1998): 1–9. http://dx.doi.org/10.1016/s0165-2427(98)00174-3.

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39

Christianson, S. W., D. L. Greiner, R. A. Hesselton, et al. "Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice." Journal of Immunology 158, no. 8 (1997): 3578–86. http://dx.doi.org/10.4049/jimmunol.158.8.3578.

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Abstract Genetic crosses produced NOD/LtSz mice doubly homozygous for the severe combined immunodeficiency (scid) mutation and the beta2m (B2m) null allele. Both NOD/LtSz-scid/scid and NOD/LtSz-scid/scid B2m(null) mice lacked mature lymphocytes and serum Ig. However, homozygosity for the B2m(null) allele also resulted in the absence of MHC class I expression, loss of NK cell activity, accumulation of iron in the liver, and rapid clearance of human IgG1. NOD/LtSz-scid/scid B2m(null) mice supported markedly elevated levels of human T cell engraftment, compared with NOD/LtSz-scid/scid control ani

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40

Miao, Miao, Henry Masengere, Guang Yu, and Fengping Shan. "Reevaluation of NOD/SCID Mice as NK Cell-Deficient Models." BioMed Research International 2021 (November 10, 2021): 1–11. http://dx.doi.org/10.1155/2021/8851986.

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Objective. Natural killer (NK) cell-deficient mice are useful models in biomedical research. NOD/SCID mice have been used as a model of this type in research. However, the actual status of NK cells in NOD/SCID mice and CB17/SCID mice in comparison with that in BALB/c mice has not been sufficiently evaluated. Methods. Splenocytes from naïve or poly(I:C)-treated mice were isolated for phenotyping and analysis of cytotoxicity-related molecules and inhibitory receptors; for cytotoxicity assay, purified NK cells were also used. Results. The proportion of splenic NK cells did not differ significantl

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Lieberman, M., G. A. Hansteen, E. K. Waller, I. L. Weissman, and A. Sen-Majumdar. "Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis." Journal of Experimental Medicine 176, no. 2 (1992): 399–405. http://dx.doi.org/10.1084/jem.176.2.399.

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Strain C.B17 scid/scid (SCID) mice, which lack functional T and B lymphocytes, show heightened susceptibility to the induction of thymic lymphomas by x-irradiation. Susceptibility is highest in thymus-chimeric SCID-BL mice (thymectomized SCID mice bearing a C57BL thymus graft). All SCID-BL lymphomas originate in the cells of the thymic graft (C57BL type) and lack murine leukemia virus expression. Both SCID and SCID-BL lymphomas are phenotypically CD4-8+ and/or CD4+8+, but only the SCID-BL tumors express CD3. Injection of C57BL or BALB/c bone marrow into irradiated SCID-BL mice prevents lymphom

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42

Cossu, Fausto. "Genetics of SCID." Italian Journal of Pediatrics 36, no. 1 (2010): 76. http://dx.doi.org/10.1186/1824-7288-36-76.

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43

Pietrucha, Barbara, Hanna Gregorek, Edyta Heropolitańska-Pliszka, and Ewa Bernatowska. "Primary Immunodeficiency with double strain break DNA (DSBs) and radiosensitvity: clinical, diagnostic and therapeutic implications." Postępy Higieny i Medycyny Doświadczalnej 72 (May 17, 2018): 449–60. http://dx.doi.org/10.5604/01.3001.0012.0547.

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Primary Immunodeficiencies (PNO) are a group of about 300 genetic disorders which result from the absence or dysfunction of the major components of the immune system. Among them an important subgroup constitute deficiencies associated with defects in DNA double strand breaks (DSBs) recognition and repair. These are primarily radiation-sensitive severe combined immune deficiencies (SCIDs) and combined immune deficiencies (CIDs) associated with genetic defects in the DNA-repair genes, which encode proteins necessary for T-cell and B cell maturation/differentiation. Due to increased risk of devel

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Shibata, Shinwa, Toshihiko Asano, Atsuo Ogura, et al. "SCID-bg mice as xenograft recipients." Laboratory Animals 31, no. 2 (1997): 163–68. http://dx.doi.org/10.1258/002367797780600107.

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SCID- bg ( scid/scid, beige/beige) is a strain of double-mutant mice with impaired lymphoid development and reduced natural killer (NK) cell activity. The present study was undertaken to evaluate the usefulness of SCID- bg mice as xenograft recipients. Fetal guineapig tissues (liver, thymus, spleen) were transplanted under the kidney capsule of the mice and their serum guineapig IgG levels were measured weekly thereafter. C.B.-17- scid and anti-asialo GM1 antiserum-treated (NK-depleted) C.B.-17- scid (C.B.-17- scid-AGM1) mice that received the identical transplants were used as controls. Throu

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45

Cox, Charlotte V., Roger S. Evely, Nicholas J. Goulden, and Allison Blair. "Stem Cells in T-ALL Have a Primitive CD133+/CD34+/CD7- Phenotype." Blood 104, no. 11 (2004): 1885. http://dx.doi.org/10.1182/blood.v104.11.1885.1885.

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Abstract The cell of origin of childhood acute lymphoblastic leukaemia (ALL) has been the subject of conflicting reports in recent years. One model suggests that many haemopoietic cell types are susceptible to transformation and the level of commitment of the target cell influences the characteristics of the resulting blast cell population. A second model suggests that primitive haemopoietic cells are the targets for transformation, with some differentiation occurring subsequent to the transformation event. This model suggests a hierarchy of progenitors may exist in ALL. In support of this lat

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46

Krowka, J. F., S. Sarin, R. Namikawa, J. M. McCune, and H. Kaneshima. "Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent." Journal of Immunology 146, no. 11 (1991): 3751–56. http://dx.doi.org/10.4049/jimmunol.146.11.3751.

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Abstract SCID-hu mice are heterochimeric animals that are constructed by transplanting human fetal thymus (Thy), liver (Liv), and/or lymph nodes into congenitally immunodeficient C.B-17 scid/scid (SCID) mice. Sensitive and specific two-color flow cytometric assays were used to evaluate human lymphocytes from peripheral blood of SCID-hu mice. Kinetic studies presented in this report show long term T lymphopoiesis in SCID-hu mice. Approximately one-half of SCID-hu mice constructed with Thy and Liv tissue develop detectable levels of circulating human T cells by 4 mo after transplantation. The av

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47

Jiang, Han-Qing, Nicolaas A. Bos, and John J. Cebra. "Timing, Localization, and Persistence of Colonization by Segmented Filamentous Bacteria in the Neonatal Mouse Gut Depend on Immune Status of Mothers and Pups." Infection and Immunity 69, no. 6 (2001): 3611–17. http://dx.doi.org/10.1128/iai.69.6.3611-3617.2001.

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ABSTRACT As a member of the indigenous gut mucosal microbiota, segmented filamentous bacteria (SFB) colonize the guts of a variety of vertebrates and invertebrates. They are potent microbial stimuli of the gut mucosal immune system. In the small intestines of mice and rats, it has been observed that SFB are absent during the suckling period and appear in high numbers shortly after weaning, then quickly retreat to the cecum and large intestine. In this study, we explored whether this microecological phenomenon resulted from the interaction between SFB and the passively acquired maternal mucosal

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Nonoyama, S., F. O. Smith, I. D. Bernstein, and H. D. Ochs. "Strain-dependent leakiness of mice with severe combined immune deficiency." Journal of Immunology 150, no. 9 (1993): 3817–24. http://dx.doi.org/10.4049/jimmunol.150.9.3817.

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Abstract Mice with immunodeficiency provide an excellent in vivo model for cell transfer experiments. In this study, we compare the extent of immune deficiency of the original CB17 severe combined immune-deficient (SCID) mice with that of two other strains of immune-deficient mice, the recently developed C3H SCID mice and the beige/nude/X-linked immune-deficient (BNX) mice. Detectable levels of serum lg (higher than 0.4 microgram/ml) were found in 79% of CB17 SCID mice studied (n = 24) and in all BNX mice (n = 12); some leaky CB17 SCID mice had normal levels of Ig. In contrast, only 15% of C3H

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Qing, Yulan, Yuan Lin, and Stanton L. Gerson. "An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment." Blood 119, no. 7 (2012): 1768–71. http://dx.doi.org/10.1182/blood-2011-05-350611.

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Abstract Although scid mice have been widely used for human HSC engraftment studies, the function of HSCs of scid mice has not been characterized. We hypothesized that the DNA repair defect of scid mice results in a stem cell defect that facilitates HSC engraftment. scid BM cells showed severely impaired repopulation potentials in the competitive repopulation assay. To assess the BM hematopoietic niche occupancy ability of scid HSC, WT BM cells were transplanted into scid mice without any conditioning and observed to achieve long-term engraftment. Furthermore, the defects of scid HSCs are inde

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Yu, Shi, Shu Diao, Jinsong Wang, Gang Ding, Dongmei Yang, and Zhipeng Fan. "Comparative Analysis of Proliferation and Differentiation Potentials of Stem Cells from Inflamed Pulp of Deciduous Teeth and Stem Cells from Exfoliated Deciduous Teeth." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/930907.

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Stem cells isolated from exfoliated deciduous teeth (SHEDs) are highly capable of proliferation and differentiation, and they represent good cell sources for mesenchymal stem cell- (MSC-) mediated dental tissue regeneration, but the supply of SHEDs is limited. A previous study found that stem cells could be isolated from inflamed tissues, but it is unknown whether primary dental pulp diagnosed with irreversible pulpitis might contain stem cells with appropriate tissue regeneration capacity. In this study, we aimed to isolate stem cells from both inflamed pulps of deciduous teeth (SCIDs) and SH

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