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Journal articles on the topic 'Sedative and hypnotic'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Tseng, Han-Yun, Shu-Han Yu, Chun-Yi Lee, et al. "Sedative–hypnotic drug use among community-dwelling elderly in Taiwan." International Psychogeriatrics 30, no. 7 (2018): 957–65. http://dx.doi.org/10.1017/s1041610217002940.

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ABSTRACTBackground:Sedative–hypnotic medication use has been related to severe adverse events and risks. This study investigated the prevalence of and characteristics associated with the use of sedatives and hypnotics among community-dwelling elderly persons aged 65 years and over in Taiwan.Methods:A representative sample of community-dwelling adults was recruited. Clinical and sociodemographic data were collected for assessing physical, mental, and cognitive functioning and disorders. Sedatives and hypnotics use was determinedviaboth self-reporting and prescription records. Logistic regressio

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Conti, Elizabeth C., Melinda A. Stanley, Amber B. Amspoker, and Mark E. Kunik. "Sedative-Hypnotic Use Among Older Adults Participating in Anxiety Research." International Journal of Aging and Human Development 85, no. 1 (2016): 3–17. http://dx.doi.org/10.1177/0091415016685330.

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Older adults are prescribed sedative-hypnotic medications at higher rates than younger adults. These are not recommended for older adults due to risk of sedation, cognitive impairment, and falls. Severe generalized anxiety disorder (GAD) is a possibly appropriate use of these medications in older people, but little is available on use of sedative-hypnotic medications among older adults with GAD. This study examined the frequency and predictors of sedative-hypnotic medication use among older adults screening positive for anxiety. 25.88% ( n = 125) of participants reported taking sedative-hypnot

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Hartung, Daniel M., Jennifer A. Lucas, Nathalie Huguet, et al. "Sedative-hypnotic Co-prescribing with Opioids in a Large Network of Community Health Centers." Journal of Primary Care & Community Health 14 (January 2023): 215013192211473. http://dx.doi.org/10.1177/21501319221147378.

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Objective: When prescribed with opioids, sedative-hypnotics substantially increase the risk of overdose. The objective of this paper was to describe characteristics and trends in opioid sedative-hypnotic co-prescribing in a network of safety-net clinics serving low-income, publicly insured, and uninsured individuals. Methods: This retrospective longitudinal analysis of prescription orders examined opioid sedative-hypnotic co-prescribing rates between 2009 and 2018 in the OCHIN network of safety-net community health centers. Sedative-hypnotics included benzodiazepine and non-benzodiazepine seda

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Bye, Elin Kristin, and Ingeborg Rossow. "Concomitant alcohol and sedative-hypnotic drug use among the elderly in Norway." Nordic Studies on Alcohol and Drugs 34, no. 1 (2017): 18–27. http://dx.doi.org/10.1177/1455072516683896.

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Background: Sedative-hypnotic drugs (i.e., tranquilizers and sleeping pills) are more often used among the elderly compared to other age groups. Concomitant use of alcohol and sedative-hypnotic drugs constitutes a particularly high risk factor for accidental injuries among the elderly. However, few studies have addressed the prevalence of concomitant alcohol and sedative-hypnotic drug use and knowledge about the characteristics of such use is meagre. Aim: To assess the prevalence of concomitant alcohol and sedative-hypnotic drug use among elderly people and to explore the characteristics of su

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Li, Dian-Jeng, Shiou-Lan Chen, Yu-Ping Chang, and Cheng-Fang Yen. "Factors Affecting Painkillers, Sedatives/Hypnotics, Nicotine, and Unhealthy Alcohol Use Among Gay and Bisexual Men in Taiwan." International Journal of Environmental Research and Public Health 17, no. 3 (2020): 851. http://dx.doi.org/10.3390/ijerph17030851.

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Substance use has become a major health problem globally for sexual minorities. However, few studies have explored multi-dimensional factors associated with smoking, drinking, and prescription drug use. We aimed to investigate the factors affecting painkiller, sedative/hypnotic, nicotine and unhealthy alcohol use among gay and bisexual men in Taiwan. We recruited 500 gay or bisexual men and assessed their experiences of using painkillers, sedatives/hypnotics, nicotine, alcohol and multi-dimensional factors with self-reported questionnaires. Multivariate logistic regression with a forward stepw

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Yang, Xiaoxuan, Youssef Jounaidi, Jennifer B. Dai, et al. "High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics." Anesthesiology 129, no. 3 (2018): 459–76. http://dx.doi.org/10.1097/aln.0000000000002281.

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Abstract What We Already Know about This Topic What This Article Tells Us That Is New Background Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered. The authors hypothesized that a sedative-hypnotic screening approach using zebrafish larvae responses to sensory stimuli would perform comparably to standard assays, and efficiently identify new active compounds. Methods The authors developed a binary outcome photomotor response assay for zebrafish larvae using a co

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Huh, Jae Hong, Sang Chun Choi, Yong Gyun Lim, Samsun Lampotang, and Eung Jung Park. "Flumazenil administration in suspected patients with acute hypnotics and sedatives poisoning: risk-benefit re-evaluation." Journal of The Korean Society of Clinical Toxicology 14, no. 2 (2016): 92–99. http://dx.doi.org/10.22537/jksct.14.2.92.

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Purpose: The use of flumazenil administration in the emergency department is still controversial because of concerns about adverse effects. The present study was conducted to re-evaluate the risk-benefit ratio associated with flumazenil administration to patients suspected of having acute hypnotics and sedatives poisoning in the emergency department. Methods: A retrospective chart review study was conducted for patients whose final diagnoses were "poisoning" and "benzodiazepine" or "sedatives-hypnotics" from Mar. 2006 to Feb. 2015. The basal characteristics of the patients, including past medi

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Davies, Dilys R. "A Comparison of Hypnotic and Non-hypnotic Users in the Group Therapy of Insomnia." Behavioural Psychotherapy 19, no. 2 (1991): 193–204. http://dx.doi.org/10.1017/s0141347300012222.

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The present study evaluated the effectiveness of a multiple treatment approach to the group treatment of hypnotic and non-hypnotic taking insomniacs. Twenty subjects sequentially assigned into four groups attended weekly group therapy over a period of 11–13 weeks. Pre- and post-treatment comparisons indicated an overall improvement of the total sample on measures of general health, benzodiazepine related symptom reduction, reduction from hypnotic sedative medication as well as on measures of the quality and quantity of sleep. Overall there was a marked similarity between hypnotic and non-hypno

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Toolika, E., M. Ravi, Narayana Prakash B, Suhas Kumar Shetty, B. Ravishankar, and HP Savitha. "A comparative pharmacological study on the effect of Tagara [Valeriana wallichii] and Jatamansi [Nardostachys jatamansi] in the management of anidra w.s.r to primary insomnia." Journal of Phytopharmacology 4, no. 3 (2015): 147–51. http://dx.doi.org/10.31254/phyto.2015.4304.

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The present study was undertaken to evaluate Tagara and Jatamansi for certain CNS activities to ascertain the basis for their use as a sedative and hypnotics. The drugs were evaluated for hypnotic and sedative, anti anxiety, anti depressant and anti psychotic activities using standard experimental protocol. The data generated suggests that the test drugs Tagara and Jatamansi have complex CNS activity profile which is not easy to categorize under general CNS activity profile. Both possess significant anti-anxiety activity without significant sedative-hypnotic activity. This increases their util

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Bramoweth, Adam D., Caroline E. Hough, Amanda D. McQuillan, et al. "Reduction of Sleep Medications via a Combined Digital Insomnia and Pharmacist-Led Deprescribing Intervention: Protocol for a Feasibility Trial." JMIR Research Protocols 12 (July 20, 2023): e47636. http://dx.doi.org/10.2196/47636.

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Background Chronic insomnia is one of the most common health problems among veterans and negatively impacts their health, function, and quality of life. Although cognitive behavioral therapy for insomnia (CBT-I) is the first-line recommended treatment, sedative-hypnotic medications remain the most common. Sedative-hypnotics, however, have mixed effectiveness, are frequently prescribed longer than recommended, and are associated with numerous risks and adverse effects that negatively impact veteran function. Meeting the treatment needs of veterans impacted by insomnia requires delivering gold s

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Tully, Isabelle, Norah Simpson, Jessica Dietch, Joshua Tutek, and Rachel Manber. "356 Examining Use and Beliefs about Sleep Medications in a Sample of Older Adults: The Role of Hypnotic Dependency." Sleep 44, Supplement_2 (2021): A142. http://dx.doi.org/10.1093/sleep/zsab072.355.

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Abstract Introduction Prevalence of insomnia and prescription of sleep medications increases in older adults and is associated with heightened risk of falls, cognitive and psychomotor detriments, and exacerbation of pre-existing conditions. The present study aimed to characterize beliefs about sleep and sleep medications, hypnotic self-efficacy, and hypnotic dependence in a sample of older adults with insomnia disorder. Methods Adults 50 years and older (N = 141) who met DSM-5 criteria for insomnia disorder were enrolled in the RCT of the Effectiveness of Stepped-Care Sleep Therapy In General

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Mahon, Rowan, Fulton Velez, Frances Thorndike, and Yuri Maricich. "0337 24-Month Patterns of Sleep Medication Use with a Prescription Digital Therapeutic for Chronic Insomnia – A Retrospective Analysis." SLEEP 46, Supplement_1 (2023): A150. http://dx.doi.org/10.1093/sleep/zsad077.0337.

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Abstract Introduction Cognitive-behavioral therapy for insomnia (CBT-I) is the recommended first-line treatment, but sedative-hypnotic medications are often used first, despite contraindications and risk of misuse. This study assessed change in sedative/hypnotic use/dosage in patients with chronic insomnia treated with Somryst® (tested as SHUTi), a prescription digital therapeutic (PDT) delivering CBT-I. Methods A retrospective claims data analysis was conducted with chronic use of prescribed sedatives/hypnotics (days’ supply: 8-200; units dispensed: &gt;12) in patients with self-identifie

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Yang, Xiaoxuan, Youssef Jounaidi, Kusumika Mukherjee та ін. "Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric Acid Type A Receptor β3 Subunits". Anesthesiology 131, № 6 (2019): 1276–91. http://dx.doi.org/10.1097/aln.0000000000002963.

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Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Transgenic mouse studies suggest that γ-aminobutyric acid type A (GABAA) receptors containing β3 subunits mediate important effects of etomidate, propofol, and pentobarbital. Zebrafish, recently introduced for rapid discovery and characterization of sedative-hypnotics, could also accelerate pharmacogenetic studies if their transgenic phenotypes reflect those of mammals. The authors hypothesized that, relative to wild-type, GABAA-β3 functional knock-out (β3-/-) zebrafish would s

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DiNapoli, Elizabeth A., Adam D. Bramoweth, Christopher Cinna, and John Kasckow. "Sedative hypnotic use among veterans with a newly reported mental health disorder." International Psychogeriatrics 28, no. 8 (2016): 1391–98. http://dx.doi.org/10.1017/s1041610216000521.

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ABSTRACTBackground:This study compared sedative hypnotic use by type of mental health diagnosis and determined factors associated with use among older veterans (65+ years) with a newly reported mental health disorder.Methods:This study used data from veterans who received primary care services at VA Pittsburgh Healthcare System (VAPHS) from January 1, 2007 to December 31, 2011 (n= 879).Results:Sedative hypnotics were commonly used in older veterans within 12-months following a newly reported mental health disorder (19.9%), particularly amongst those with insomnia (41.7%). The number of newly r

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Fixen, Danielle R., Samantha A. Farro, Prajakta Shanbhag, Bennett L. Parnes, and Maria V. Vejar. "Multidisciplinary Approach to Deprescribing Sedative-Hypnotic Medications in Geriatric Primary Care." Journal of Primary Care & Community Health 13 (January 2022): 215013192211034. http://dx.doi.org/10.1177/21501319221103416.

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Introduction/Objectives: Due to the risks associated with sedative hypnotic medications in older adults, our study evaluated the impact of a multidisciplinary approach to deprescribing in geriatric primary care clinics. Methods: The study was a retrospective review of older adults at 2 academic, geriatric primary care clinics who were prescribed sedative-hypnotic medications. Patients were mailed an education packet of information that included working with the clinical pharmacy team, behavioral health team, or both in order to deprescribe their sedative-hypnotic medication. The study assessed

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Patten, Scott B., Jeanne V. A. Williams, and Edgar J. Love. "Self-Reported Depressive Symptoms following Treatment with Corticosteroids and Sedative-Hypnotics." International Journal of Psychiatry in Medicine 26, no. 1 (1996): 15–24. http://dx.doi.org/10.2190/bl97-bwfr-4qr0-cey7.

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Objective: To evaluate associations between exposure to corticosteroids or sedative-hypnotic medications and incident self-reported depressive symptoms in medical inpatients. Method: The study utilized a prospective cohort design, focusing on acute depressive symptoms developing soon after medication exposure. The incidence of self-reported depressive symptoms was evaluated using a modified version of the Center for Epidemiological Studies Depression Rating Scale (CES-D). The incidence of depressive symptoms in subjects newly exposed to corticosteroids and sedative-hypnotics was compared to th

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Efraim Samson, Wahyudi Abdul Hamid Ridwan, and Chomsa Dintasari Umi Baszary. "POTENSI SEDATIF-HIPNOTIK DAUN KAYU GALALA (ERYTHRINA LITHOSPERMA) SEBAGAI KANDIDAT OBAT INSOMNIA." Jurnal Matematika Sains dan Teknologi 20, no. 2 (2019): 84–94. http://dx.doi.org/10.33830/jmst.v20i2.166.2019.

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The use of drugs from the sedative-hypnotic group to overcome the problem of insomnia began to be abandoned and turned to the use of traditional medicines made from plants. The purpose of this study is to determine the potential of kayu galala leaves (Erythrina lithosperma) as a candidate for medicine of insomnia. A total of 15 male mice (Mus musculus) aged ± 2 months weighing ± 20 grams, divided into control mice (K- and K +), and mice treated with infusion dose of kayu galala leaves, ie P1 0.3 mL/mice; P2 0.5 mL/mice; and P3 0.7 mL/mice. The results showed that kayu galala leaves had a sedat

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Sadino, Asman, Sekar Ratih Pramesti, Suwendar Suwendar, and Riza Apriani. "UJI AKTIVITAS HIPNOTIK-SEDATIF EKSTRAK ETANOL 70% DAUN PATIKAN KEBO (Euphorbia hirta Linn) PADA MENCIT PUTIH JANTAN GALUR SWISS WEBSTER." Pharma Xplore : Jurnal Sains dan Ilmu Farmasi 10, no. 1 (2025): 78–90. https://doi.org/10.36805/jpx.v10i1.10077.

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Sleep disorders such as insomnia are common health issues that significantly impact quality of life. Pharmacological therapies using hypnotic-sedative drugs often cause side effects, highlighting the need for alternative treatments derived from natural sources. One plant with potential hypnotic-sedative properties is patikan kebo (Euphorbia hirta L.). This study aimed to evaluate the hypnotic-sedative activity of 70% ethanol extract of patikan kebo leaves in male Swiss Webster mice. The extract was obtained through maceration using 70% ethanol and subsequently analyzed for phytochemical conten

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Aker, John. "Sedative versus hypnotic." Journal of Emergency Nursing 22, no. 4 (1996): 270. http://dx.doi.org/10.1016/s0099-1767(96)80007-9.

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Pejo, Ervin, Xiaojuan Zhou, S. Shaukat Husain та Douglas E. Raines. "Sedative-hypnotic Binding to 11β-hydroxylase". Anesthesiology 125, № 5 (2016): 943–51. http://dx.doi.org/10.1097/aln.0000000000001304.

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Abstract Background Etomidate potently suppresses adrenocortical steroid synthesis with potentially deleterious consequences by binding to 11β-hydroxylase and inhibiting its function. The authors hypothesized that other sedative-hypnotics currently in clinical use or under development (or their metabolites) might bind to the same site at clinically relevant concentrations. The authors tested this hypothesis by defining etomidate’s affinity for this site and the potencies with which other sedative-hypnotics (and their metabolites) inhibit etomidate binding. Methods 3H-etomidate’s binding to adr

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Zhou, Ying, Peiran Yin, Bin Li, et al. "Effect of Sedative-Hypnotic Medicines on Mortality in Peritoneal Dialysis Patients with Sleep Disorders: A Retrospective Cohort Study." Blood Purification 45, no. 1-3 (2017): 95–101. http://dx.doi.org/10.1159/000484922.

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Background: Sedative-hypnotic medication is widely used among continuous ambulatory peritoneal dialysis (CAPD) patients with sleep disorders; however, its effect on mortality has rarely been investigated. Methods: Logistic regression was employed to identify factors associated with sedative-hypnotic medication, whose effect on mortality was evaluated by Cox proportional hazards models. Results: A total of 146 CAPD patients with sleep disorders were recruited, of which 46 patients (31.5%) used either benzodiazepines or zolpidem. Sedative-hypnotic medication was more frequently used by older pat

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Sharikabad, Mohammad Nouri, Svetlana Skurtveit, Hilchen Thode Sommerschild, et al. "Morbidity among Adolescent Hypnotic Drug Users in Norway: An Observational Population-Based Study." Journal of Clinical Medicine 13, no. 4 (2024): 1075. http://dx.doi.org/10.3390/jcm13041075.

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We have previously shown that the use of hypnotic drugs increased among young Scandinavians during 2012–2018. This study aimed to explore psychiatric and somatic morbidity among adolescent hypnotic drug users in a cohort study of 13–17-year-old individuals during 2008–2018 in Norway. Data sources were (i) prescription data from the Norwegian Prescription Database linked to specialist health care diagnoses from the Norwegian Patient Registry and (ii) sleep disorder diagnoses from the Primary Health Care Database. Hypnotic drugs were defined as the sedative antihistamine alimemazine and the ATC

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Kim, Seonghui, Duhyeon Kim, Min Young Um, et al. "Marine Polyphenol Phlorotannins as a Natural Sleep Aid for Treatment of Insomnia: A Review of Sedative–Hypnotic Effects and Mechanism of Action." Marine Drugs 20, no. 12 (2022): 774. http://dx.doi.org/10.3390/md20120774.

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Insomnia is a common sleep disorder. Natural sleep aids are gaining worldwide popularity as alternatives to prescription drugs for improving sleep. Recently, numerous studies have investigated the sedative–hypnotic effects of the polyphenols of terrestrial plants. The hypnotic effects of marine polyphenols have also been studied in recent years. Phlorotannins are marine polyphenols that are found only in brown algae. Phlorotannins exert sedative–hypnotic effects via the gamma-aminobutyric acid type A-benzodiazepine receptor. In addition, the brown seaweed Ecklonia cava supplement containing ph

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Stahl, Stephen M. "Selective Histamine H1 Antagonism: Novel Hypnotic and Pharmacologic Actions Challenge Classical Notions of Antihistamines." CNS Spectrums 13, no. 12 (2008): 1027–38. http://dx.doi.org/10.1017/s1092852900017089.

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Numerous “antihistamines” as well as various psychotropic medications with antihistamine properties are widely utilized to treat insomnia. Over-the-counter sleep aids usually contain an antihistamine and various antidepressants and antipsychotics with antihistamine properties have sedative-hypnotic actions. Although widely used for the treatment of insomnia, many agents that block the histamine H1 receptor are also widely considered to have therapeutic limitations, including the development of next-day carryover sedation, as well as problems with chronic use, such as the development of toleran

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Tubbs, Andrew, Michelle Naps, Michael Grandner, and Louis Rivera. "350 Opioid Use and Abuse are Associated with Use of Sedative Hypnotic Medications." Sleep 44, Supplement_2 (2021): A140. http://dx.doi.org/10.1093/sleep/zsab072.349.

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Abstract Introduction The Department of Health and Human Services recently reported that 10.3 million people misused opioid drugs in 2018. Recent research attributed 21% of the deaths from opioid overdose to benzodiazepines. The overdose data and clinical experience show that opioid misusers commonly complain of insomnia and use hypnotic medications to self-medicate their sleep disturbance. At the same time, it remains unclear from a scientific perspective whether those who use/abuse opioids are more likely to use drugs in the sedative-hypnotic medication category. Consequently, the present st

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Yong, Shire Li, Huey Jing Renee Tan, Norliza Bt Chemi, et al. "Prescribing Pattern of Benzodiazepine Receptor Agonists (BZRA) and Factors Associated With Duration of BZRA Use in a Malaysian Psychiatry Outpatient Clinic." NOVEMBER ISSUE 18, no. 6 (2022): 193–201. http://dx.doi.org/10.47836/mjmhs.18.6.26.

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Introduction: Benzodiazepine receptor agonist (BZRA) are among the most frequently used psychotropic medications worldwide. We aim to understand the pattern of prescription of BZRA in the government healthcare facilities and identify factors affecting the likelihood of BZRA prescription and duration of use. Method: This is a retrospective study. Data was obtained from record of outpatient clinical notes. Medications studied were midazolam, alprazolam, lorazepam, bromazepam, clonazepam, diazepam and zolpidem. Mean duration per prescription, mean dosage per prescription and duration per patient

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Alsultan, Mohammed M. "The Use of Psychotropic Medications Before and During the COVID-19 Pandemic and Its Associated Factors." Journal of Clinical Medicine 13, no. 23 (2024): 7419. https://doi.org/10.3390/jcm13237419.

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Background/Objectives: The prevalence of mental health disorders has been rising in Saudi Arabia, which may have been exacerbated by the COVID-19 pandemic. Therefore, the aim of our study was to examine the usage patterns of various psychotropic drugs before and during the pandemic. Methods: This cross-sectional study was conducted at the psychiatric outpatient clinic of a single hospital in Saudi Arabia from 1 October 2018 to 31 March 2023. Electronic medical records were used to gather information on all adult patients who were prescribed at least one antidepressant, antipsychotic, or anxiol

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Skottheim, Andreas, Hugo Lövheim, Ulf Isaksson, Per-Olof Sandman, and Maria Gustafsson. "Insomnia symptoms among old people in nursing homes." International Psychogeriatrics 30, no. 1 (2017): 77–85. http://dx.doi.org/10.1017/s1041610217001703.

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ABSTRACTBackground:Insomnia symptoms are common among old people, and hypnotics and sedative drugs are often prescribed in spite of small benefits. The aim of this study was to estimate the prevalence of insomnia symptoms and to analyze the association between insomnia symptoms, cognitive level, and prescription of hypnotics and sedatives among old people living in nursing homes.Methods:The study comprised 2,135 people living in nursing homes in the county of Västerbotten, Sweden. Data concerning hypnotic and sedative drugs, cognitive function, and prevalence of insomnia symptoms were collecte

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Tai, Chen-Yu, Hsin-Yi Liu, Juan P. Cata, et al. "The Association between General Anesthesia and New Postoperative Uses of Sedative–Hypnotics: A Nationwide Matched Cohort Study." Journal of Clinical Medicine 11, no. 12 (2022): 3360. http://dx.doi.org/10.3390/jcm11123360.

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Sedative–hypnotic misuse is associated with psychiatric diseases and overdose deaths. It remains uncertain whether types of anesthesia affect the occurrence of new postoperative uses of sedative–hypnotics (NPUSH). We used reimbursement claims data of Taiwan’s National Health Insurance and conducted propensity score matching to compare the risk of NPUSH between general and neuraxial anesthesia among surgical patients who had no prescription of oral sedative–hypnotics or diagnosis of sleep disorders within the 12 months before surgery. The primary outcome was NPUSH within 180 days after surgery.

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Raul, Namita, Ketan Vinayakrao Hatware, Sanjay Sharma, Kiran Patil, Sravani Karri, and Rupesh Kumar Gautam. "ANTIOXIDANT, SEDATIVE AND HYPNOTIC POTENTIAL OF MILK EXTRACT OF MYRISTICA FRAGRANS: A COMPLIMENTARY MEDICINE FOR THE MANAGEMENT OF INSOMNIA." INDIAN DRUGS 57, no. 11 (2021): 76–82. http://dx.doi.org/10.53879/id.57.11.12725.

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The Myristica fragrans (MF) is well known in Ayurveda for many therapeutic uses. The present research work was carried out to investigate the antioxidant (in vitro), sedative and hypnotic effects of the MFmilk extracts in Wistar rats. The extraction was carried out by hot percolation and cold maceration methods. The phytochemical, HPLC and pharmacological evaluations were done. The overall sedative and hypnotic effects of the different extracts were evaluated using the parameters locomotor activity, muscle strength and thiopental induced sleeping time. The milk extracts shown the presence of q

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Shapiro, Anna Bovill, Michael A. Smith, Christine T. Moshe, Gregory T. Frey, and Ryan M. Chadha. "Remimazolam As a Sole Sedative Agent for Gastrostomy Tubes Placed in the Interventional Radiology Suite: A Case Series." A&A Practice 18, no. 8 (2024): e01839. http://dx.doi.org/10.1213/xaa.0000000000001839.

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Remimazolam is an ultrashort acting intravenous sedative-hypnotic approved for procedural sedation. We report a series of 8 cases of radiographically placed gastrostomy tubes using remimazolam as the sole anesthetic agent. Interventional radiology (IR) gastrostomy tube placement entails anesthetizing often complex patients in a nonoperating room environment. All 8 patients reported here underwent successful gastrostomy tube placement without the need for conversion to general anesthesia. Remimazolam is a feasible option to sedate patients for gastrostomy tube placement in the IR suite.

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Liang, Zengenni, Xue-bo Shang, Jin Su, et al. "Alternative Extraction Methods of Essential Oil From the Flowers of Citrus aurantium L. Var Daidai Tanaka: Evaluation of Oil Quality and Sedative-Hypnotic Activity." Natural Product Communications 16, no. 3 (2021): 1934578X2110040. http://dx.doi.org/10.1177/1934578x211004061.

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The aim of this study was to analyze the content of hypnotic components in the essential oil from Citrus aurantium flowers (EDD), extracted by different methods, and to characterize its sedative-hypnotic effects. The sedative-hypnotic capacity of EDD was evaluated using pentobarbital-induced sleeping assays, locomotor activity tests and GABAA receptor antagonists. The results showed that EDD extracted by steam and water distillation (SWD), hydrodistillation (HD), and ultrasound-assisted hydrodistillation (UHD) had as their main components linalool, linalyl acetate, and limonene, comprising mor

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Naik, Durga* Ashoka Shenoy M. "Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Plumeria obtusa Flowers in Experimental Mice." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 580–86. https://doi.org/10.5281/zenodo.14278703.

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The current study aimed to assess the sedative and hypnotic effects of the ethanolic extract of Plumeria obtusa flowers (POEE) in mice using the hole board test and potentiation of pentobarbital-induced sleeping time test model. The extract’s effects on sedative and hypnotic-related behaviors were evaluated by counting the number of head dips in the hole board test after being given at two doses of 100 mg/kg and 200 mg/kg. The duration of sleep and its initiation were noted in the potentiation of the pentobarbital-induced sleeping time test. In the hole board test, POEE-treated animals s

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Page, Andrew C., and Gavin Andrews. "Do Specific Anxiety Disorders Show Specific Drug Problems?" Australian & New Zealand Journal of Psychiatry 30, no. 3 (1996): 410–14. http://dx.doi.org/10.3109/00048679609065007.

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Objective: Comorbidity between anxiety and substance use disorders was examined. The hypothesis was tested that social phobics may report greater problem alcohol use (if alcohol is used to manage social anxiety) while problem use of sedative-hypnotics may be greater in people with panic (who may be over-prescribed anxiolytics because they repeatedly seek medical assistance). Method: Self-reported lifetime rates of drug and alcohol problems were assessed with the computerised Diagnostic Interview Schedule — Revised. Subjects were 146 consecutive patients treated for panic disorder (with and wit

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Erwin, William J., Courtney Goodman, and Tammy Smith. "Effectiveness of a direct-to-consumer written health education program in the reduction of benzodiazepine and sedative-hypnotic use in an elderly population at a single Veterans Affairs medical center." Mental Health Clinician 8, no. 3 (2018): 100–104. http://dx.doi.org/10.9740/mhc.2018.05.100.

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Abstract Introduction: The use of benzodiazepines and sedative-hypnotics in the elderly is associated with a significant risk of delirium, falls, fractures, cognitive impairment, and motor vehicle accidents. This quality improvement project applies a direct-to-consumer intervention to an elderly veteran population to reduce the use of these medications. Methods: Patients aged 75 and older currently taking a benzodiazepine and/or a sedative-hypnotic were included in the project. Direct-to-consumer education intervention letters were mailed to patients within 30 days of their next appointment. T

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Shahed-Al-Mahmud, Md. "Evaluation of sedative and hypnotic activities of ethanolic extract of leaves of Cleome rutidosperma DC. (Capparidaceae) in mice." Journal of Pharmaceutics and Therapeutics 4, no. 1 (2018): 215–23. http://dx.doi.org/10.18314/jpt.v4i1.1356.

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Cleome rutidosperma DC. (Capparidaceae) traditionally used medicine for insomnia and depression management. The aim of the recent study conducted to investigate the sedative and hypnotic activities of ethanolic extract from the leaves of C. rutidosperma (EECR) in Swiss Albino mice. Neuropharmacological test on mice employed to this study sedative (open field, hole cross, hole- board and rota-rod tests) and hypnotic (thiopental sodium-induce sleeping test) activities of EECR in mice model. The acute toxicity study and phytochemical analysis of EECR also carried out. EECR exhibits significant (p

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Eftimov, Miroslav Ts, and StefkaV Valcheva-Kuzmanova. "Investigation of Aronia Melanocarpa Fruit Juice for Sedative-Hypnotic Effects in Rats." Journal of Biomedical and Clinical Research 11, no. 1 (2018): 77–82. http://dx.doi.org/10.2478/jbcr-2018-0012.

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Summary Aronia melanocarpa fruit juice (AMFJ) has been intensively studied for effects on the central nervous system. The study aimed to investigate AMFJ for possible sedative-hypnotic effects in rats after acute and subchronic administration. Male Wistar rats were treated orally with three doses of AMFJ (2.5, 5.0 and 10.0 ml/kg) either once (acute treatment) or in 30 days (subchronic treatment). Control rats were similarly treated with distilled water. The tests were performed 1 hour after the last AMFJ administration. The possible sedative-hypnotic effects of the juice were investigated in t

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&NA;. "Sedative/hypnotic withdrawal a problem." Reactions Weekly &NA;, no. 444 (1993): 4. http://dx.doi.org/10.2165/00128415-199304440-00005.

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Levin, Gary M. "Trends in sedative-hypnotic therapy." Mental Health Clinician 4, no. 2 (2014): 40. http://dx.doi.org/10.9740/mhc.n193671.

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Kassam, Aliya, Brian Carter, and Scott B. Patten. "Sedative Hypnotic Use in Alberta." Canadian Journal of Psychiatry 51, no. 5 (2006): 287–94. http://dx.doi.org/10.1177/070674370605100504.

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Simonson, William. "New sedative/hypnotic dosing guidelines." Geriatric Nursing 35, no. 4 (2014): 306–7. http://dx.doi.org/10.1016/j.gerinurse.2014.06.003.

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Campagna, Jason A., Kevin Pojasek, David Grayzel, John Randle, and Douglas E. Raines. "Advancing Novel Anesthetics." Anesthesiology 121, no. 6 (2014): 1203–16. http://dx.doi.org/10.1097/aln.0000000000000416.

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Abstract Background: Cyclopropyl-methoxycarbonyl metomidate (CPMM, also known as ABP-700) is a second-generation “soft” (i.e., metabolically labile) etomidate analogue. The purpose of this study was to characterize CPMM’s pharmacology in beagle dogs in preparation for potential first in human phase 1 clinical trials. Methods: CPMM’s and etomidate’s hypnotic activity and duration of action were assessed using loss of righting reflex and anesthesia score assays in three or four dogs. Their pharmacokinetics were defined after single bolus administration and single bolus followed by 2-h infusion.

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Chen, Luge, Yingwei Liu, Dawei Xu, et al. "Beta-Myrcene as a Sedative–Hypnotic Component from Lavender Essential Oil in DL-4-Chlorophenylalanine-Induced-Insomnia Mice." Pharmaceuticals 17, no. 9 (2024): 1161. http://dx.doi.org/10.3390/ph17091161.

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With the increasing prevalence of insomnia-related diseases, the effective treatment of insomnia has become an important health research topic. Lavender (Lavandula angustifolia Mill.) essential oil (LEO) is a commonly used medicine for the treatment of insomnia and neurological disorders. However, neither the active components nor its sedative–hypnotic mechanism have been fully discovered. This study aimed to screen the main active terpenes and discover the possible mechanism of LEO through network pharmacology in the treatment of insomnia-related diseases, as well as to verify our hypothesis

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Emam, Abdulaziz Sulaiman, Hani Safi Mujalid, Ibrahim Issa Alissa, et al. "Risk Factors and Early Warning Signs of Suicide Attempt for Patients on Sedatives and Antidepressants." JOURNAL OF HEALTHCARE SCIENCES 04, no. 12 (2024): 674–82. https://doi.org/10.52533/johs.2024.41206.

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Suicide remains a significant global health concern, often linked to psychiatric conditions such as depression and anxiety. Sedative-hypnotic and antidepressant medications are widely prescribed to manage these conditions, yet their relationship with suicide attempts is complex and controversial. This narrative review explores the risk of suicide attempts associated with sedative-hypnotics, such as benzodiazepines and non-benzodiazepine sleep aids, and antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs). Evidence suggests that both classes of medications may elevate s

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Li, Dian-Jeng, Yu-Ping Chang, Yi-Lung Chen, and Cheng-Fang Yen. "The Impact of Emotional Symptoms and Family Support on the Association Between Homophobic Bullying and Sedative/Hypnotic Use among Gay and Bisexual Men in Taiwan: A Moderated Mediation Model." International Journal of Environmental Research and Public Health 17, no. 11 (2020): 3870. http://dx.doi.org/10.3390/ijerph17113870.

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Sedative/hypnotic use and homophobic bullying have become a big mental health concern for gay and bisexual men. However, few studies have investigated the mediators and moderators of the association between them. The current study aimed to build a conceptual model to estimate the mediating effect of emotional symptoms and the moderating effect of family support on this association among gay and bisexual men in Taiwan. A total of 500 gay or bisexual men were recruited for the study. Their history of homophobic bullying, their experience of sedative/hypnotic use, their perceived family support,

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Dhar, Ananta Sutra, Mahbubur Rahman, Md Rajdoula Rafe, and Md Islam Molla. "Assessment of antidepressant and sedative-hypnotic activities of methanolic crude extracts of Stephania japonica (Thunb.) Miers. whole plants." Current Issues in Pharmacy and Medical Sciences 33, no. 1 (2020): 51–55. http://dx.doi.org/10.2478/cipms-2020-0010.

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AbstractIn this study, methanolic crude extracts of Stephania japonica (Thunb.) Miers. (MESJ) whole plants were examined for possible antidepressant and sedative-hypnotic activities. Herein, the forced swimming test and tail suspension test were conducted to explore the antidepressant activity. In addition, the open field test and hole-board test were performed to evaluate the sedative-hypnotic activities. In the acute toxicity test, the MESJ ensured safety up to a dose of 2000 mg/kg, p.o. The experimental doses were 100 and 200 mg/kg p.o. In both the forced swimming test and tail suspension t

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Perry, Paul J., and Bruce Alexander. "Sedative/Hypnotic Dependence: Patient Stabilization, Tolerance Testing, and Withdrawal." Drug Intelligence & Clinical Pharmacy 20, no. 7-8 (1986): 532–37. http://dx.doi.org/10.1177/106002808602000702.

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Physical dependence to sedative/hypnotic drugs is not an uncommon clinical problem. The withdrawal syndrome is analogous to alcohol withdrawal, except the duration of the syndrome occurs over a longer period of time with the symptoms being less intense than generally encountered with alcohol. The potential for withdawal reactions is probably greater for the shorter-acting agents than the longer-acting drugs. Potentially dependent sedative/hypnotic users require stabilization of their symptoms initially, followed by tolerance testing. If tolerant, the patients should be withdrawn using either a

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Lin, Sisi, Bo Nie, Ke Song, Ren Ye, and Zhengzhong Yuan. "Pinelliae Rhizoma Praeparatum Cum AlumineExtract: Sedative and Hypnotic Effects in Mice and Component Compounds." BioMed Research International 2019 (April 28, 2019): 1–9. http://dx.doi.org/10.1155/2019/6198067.

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Pinelliae Rhizoma Praeparatum Cum Alumine(PRPCA) is useful for eliminating dampness and phlegm in clinical settings, targeting the main mechanisms of insomnia as defined in traditional Chinese medicine. However, little is known regarding the sedative and hypnotic effects of PRPCA. In the present study, we examined the sedative effects of PRPCA via a locomotor activity test and aimed to determine the most appropriate concentration of PRPCA for achieving these effects. The strongest sedative effects were observed at a PRPCA concentration of 0.45 g/ml. In addition, we investigated the hypnotic ef

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Muhammad, Naveed, Mohammad Saeed, Haroon Khan, Achyut Adhikari, and Khalid Mohammed Khan. "Muscle Relaxant and Sedative-Hypnotic Activities of Extract ofViola betonicifoliain Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin." Journal of Chemistry 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/326263.

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The crude methanolic extract of the whole plant ofViola betonicifolia(VBME) was investigated for anxiolytic, muscle relaxant, sleep induction, antidepressant, and sedative activities) to ascertain its scientific values. VBME showed a significant (P<0.05) dose dependent anxiolytic action in staircase test. In muscle relaxant paradigms, a dose dependent muscle relaxation was observed. For phenobarbitone sleep induction test, VBME notably (P<0.05) reduced the latency time and increased total sleeping duration. Our tested extract was found free of any antidepressant activity, while the movem

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Wang, Pei, Siyuan Xin, Zheng Wang, et al. "Chaihu-Longgu-Muli Decoction promotes sleep in mice with insomnia." Tropical Journal of Pharmaceutical Research 22, no. 5 (2023): 1037–42. http://dx.doi.org/10.4314/tjpr.v22i5.15.

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Purpose: To determine the hypnotic and sedative effects, and the mechanism of action of ChaihuLonggu-Muli Decoction (CLMD) in mice with insomnia. Methods: A mice model induced with insomnia using p-chlorophenylalanine (PCPA), was established. The sedative and hypnotic effects of CLMD on mice were evaluated by animal behavioral tests. The animals were separated into four experimental groups: (1) control group, (2) PCPA group, (3) PCPA + 5 mg/kg CLMD group, and (4) CPA + 10 mg/kg CLMD group. The 5-HTR1A expression was determined by western blot. The expression levels of the neurotransmitte

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