Log in

Relevant bibliographies by topics / Signalling pathway / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Signalling pathway.

Dissertations / Theses on the topic 'Signalling pathway'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Signalling pathway.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Baumann, Fabrizio. "Cell signalling through the Wnt pathway /." [S.l.] : [s.n.], 2004. http://www.zb.unibe.ch/download/eldiss/04baumann_f.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Ng, Ming-him. "Ras signalling pathway and MLL-rearranged leukaemias." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B3643419X.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Buchanan, V. S. "Components of the Ret oncogene signalling pathway." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597050.

Full text

Abstract:

The Multiple Endocrine Neoplasia type 2 syndromes are dominantly inherited cancer syndromes of tumour formation (affecting the thyroid C-cells, the adrenal chromaffin cells and the parathyroids) and developmental abnormalities. Germline activating mutations in the <I>ret</I> proto-oncogene, encoding a receptor tyrosine kinase (RTK), have previously been shown to predispose to MEN 2. In order to understand how Ret mutations cause MEN 2, it is important to understand the biology of Ret, including the signal transduction pathways recruited by both the normal and mutant Ret receptors. I have attem

APA, Harvard, Vancouver, ISO, and other styles

4

Ng, Ming-him, and 吳明謙. "Ras signalling pathway and MLL-rearranged leukaemias." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37238656.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Horton, Caroline Alison. "Computational modelling of cell signalling pathway dynamics." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433816.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Pogson, Mark. "Modelling the intracellular NF-κB signalling pathway". Thesis, University of Sheffield, 2006. http://etheses.whiterose.ac.uk/10353/.

Full text

Abstract:

NF-κB is a transcription factor which is central to the regulation of genes involved in inflammatory and immune responses. Understanding the operation of NF-κB and its associated intracellular signalling pathway is essential in order to control a wide range of chronic inflammatory diseases, including asthma and rheumatoid arthritis. Abnormalities in the pathway are present in a variety of human cancers and may also affect the pathogenesis of Alzheimer's disease. Computational modelling of the signalling pathway is necessary to overcome the practical limitations of biological experiments and to

APA, Harvard, Vancouver, ISO, and other styles

7

Annavarapu, Srinivas Rao. "Characterisation of Wnt signalling pathway in rhabdomyosarcoma." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3009225/.

Full text

Abstract:

Introduction: Rhabdomyosarcoma (RMS) remains one of the most challenging tumours in paediatric oncology, accounting for around 5% of all malignant paediatric tumours. Of the two major subtypes of RMS, embryonal and alveolar, the latter portends a poorer clinical outcome. Canonical Wnt signalling pathway is an important evolutionarily conserved signalling pathway that is required for muscle development and embryonal somite patterning. β-Catenin is a potent nuclear transcriptional activator and is the central effector of the canonical Wnt signalling pathway. Interestingly, constitutional activat

APA, Harvard, Vancouver, ISO, and other styles

8

Brightman, Frances A. "Computer simulation of a growth factor signal transduction pathway." Thesis, Oxford Brookes University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340868.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Filippi, Marta Cristina. "Signalling pathway in appressorium formation in Magnaporthe grisea." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1109.

Full text

Abstract:

We identified a synthetic hexapeptide that blocks Magnaporthe grisea appressorium formation, in artificial hydrophobic surface. The results suggest that peptides interfere with surface recognition. M. grisea non pathogenic pth1 mutants were complemented by N. crassa orthologous gene suggesting that the biochemical function of pth1 has not evolved specifically to play a role in appressorium development.

APA, Harvard, Vancouver, ISO, and other styles

10

Hardcastle, Zoe. "The Sonic Hedgehog signalling pathway in tooth development." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368160.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Patel, Rakesh Nalin. "Regulation of the ATR signalling pathway by Adenovirus." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/3951/.

Full text

Abstract:

Ad5 and Ad12 inhibit ATR-dependent Chk1 phosphorylation. Ad5 E4orf3 promotes the relocalization of the MRN complex in order to inhibit Chk1 activation during infection, whereas Ad12 E4orf3 is unable to inactivate MRN by this method. Here we show that Ad12 inhibits Chk1 phosphorylation by targeting TopBP1, Timeless and Tipin for degradation. We have determined that Ad12 E4orf6 associates with the cellular Cul2-containing ubiquitin ligase to promote TopBP1 degradation. We have shown that Ad5 and Ad12 differentially activate Cullin-containing ubiquitin ligase complexes during infection. Furthermo

APA, Harvard, Vancouver, ISO, and other styles

12

Arifin, Khaizurin T. "Creating an orthogonal signalling pathway in S. cerevisiae." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/57584/.

Full text

Abstract:

The pheromone mating pathway in baker’s yeast Saccharomyces cerevisiae enables this organism to initiate a developmental response upon detection of a mating pheromone. Stimulation of the Ste2 receptor by an external trigger molecule in one of the haploid mating cells of yeast MATa, results in the transcriptional induction of a subset of yeast genes. The aim of this study is to convert this system into a readily measurable response, to function as a biosensor. It is crucial for the improved system to be exclusive from the wild-type response. A successful improved system should be able to detect

APA, Harvard, Vancouver, ISO, and other styles

13

Lai, Fan. "Phosphate sensing and signalling pathway in Arabidopsis thaliana." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/15185.

Full text

Abstract:

We analysed immediate-early local and systemic responses to the perception of Pi in Pi-deplete plants or suspension cells. In Pi-deplete plants or cells, RNA abundance of Pi starvation-induced (PSI) genes is very rapidly downregulated in response to Pi or phosphonate, a non-metabolic analogue of Pi. This indicates that Pi perception, not its metabolism is the crucial event in Pi-signalling. We proposed a model for local Pi signalling in which the perception of Pi controls the stability of negative regulators of downstream responses. Systemic signalling was examined in a split-root system. Pi

APA, Harvard, Vancouver, ISO, and other styles

14

Wong, Martin Kin Lok. "Unravelling the insulin signalling pathway using mechanistic modelling." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16879.

Full text

Abstract:

Type two diabetes affects 5% of the world's population and is increasing in prevalence. A key precursor to this disease is insulin resistance, which is characterised by a loss of responsiveness to insulin in liver, muscle and adipose tissue. This thesis focuses on understanding insulin signalling using the 3T3-L1 adipocyte cell model. Computational modelling was used to generate quantitative predictions in the signalling pathways of the adipocyte, many of which are mediated by enzymatic reactions. This study began by comparing existing enzyme kinetic models and evaluating their applicability

APA, Harvard, Vancouver, ISO, and other styles

15

Collu, Giovanna Maria. "Crosstalk between dishevelled and the notch signalling pathway." Thesis, University of Manchester, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492040.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Flack, Joshua Edwin. "Mechanisms of molecular switching in the Wnt signal transduction pathway." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284206.

Full text

Abstract:

Wnt signalling is a critical cellular communication pathway controlling cell fate in all metazoan organisms. Timely activation of this pathway is crucial to coordinate development, control homeostasis of adult tissues, and to avoid cancer. Wnt signal transduction depends primarily on the activities of three multiprotein complexes; the 'degradasome', which targets the central effector β-catenin for degradation in the absence of Wnt; the 'signalosome', which is assembled by Dishevelled upon Wnt-receptor binding to inactivate the degradasome, thus allowing β-catenin to accumulate; and the 'enhanc

APA, Harvard, Vancouver, ISO, and other styles

17

Wahl, Lloyd. "Decoding the structure WWP2 in the TGFβ signalling pathway". Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/59404/.

Full text

Abstract:

The secret to the specificity of the ubiquitin-proteasome system lies in the protein-protein interaction domains of the diverse group of E3 enzymes. WWP2 is one such E3 enzyme, and the relevant protein-protein interaction domain is the WW domain. WWP2 has four WW domains which are used to interact with proline-rich motifs found in the sequences of the Smad signalling proteins that propagate or inhibit the TGFβ pathway, and in so doing, allows WWP2 to regulate its Smad targets. WWP2 has three isoforms that are known to participate in regulation of TGFβ signalling, but, even amongst isoforms of

APA, Harvard, Vancouver, ISO, and other styles

18

Saldanha, Gerald Stephen. "The Hedgehog signalling pathway and its role in cancer." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29393.

Full text

Abstract:

Mutations in Hedgehog (Hh) pathway genes such as Patched1 are of established importance in Basal cell carcinoma (BCC). However, BCC is unusual because it has indolent behaviour and rarely metastasises. Hh pathway gene mutations are rare in cancers with more typical malignant behaviour, leading to the hypothesis that the pathway plays an important role in BCC but has limited importance in cancers with typical malignant behaviour. This has been addressed in three ways. First, evidence that superficial BCC is a clonal proliferation driven by alterations at the Patched1 locus was sought. Second, e

APA, Harvard, Vancouver, ISO, and other styles

19

Malinauskas, Tomas. "Structural and functional studies of Wnt signalling pathway antagonists." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558451.

Full text

Abstract:

Wnt morphogens control embryonic development and adult tissue homeostasis. Deregulation of the Wnt signalling pathway leads to human diseases. This thesis covers work on two antagonists of the Wnt signalling pathway, Wnt inhibitory factor 1 (WIF-l) (Chapters 1 to 5) and secreted Frizzled-related protein 1 (sFRP-l) (Chapters 1 and 6). In vertebrates the N- terminal WIF domain of the six-domain WIF-1 and the cysteine-rich domain of the two- domain sFRP-1 bind to Wnt proteins and inhibit signal transduction. My human WIF domain crystal structure reveals a novel binding site for phospholipid. Two

APA, Harvard, Vancouver, ISO, and other styles

20

Abutaily, Ahmed Saad Abdullah Abutaily. "Immunohistochemical characterisation and WNT signalling pathway in malignant mesothelioma." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273755.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

De, Celis Ibeas Jesus Maria. "Identification of new targets of the notch signalling pathway." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621218.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Mansour, M. R. "Role of the Notch signalling pathway in acute leukaemia." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1420122/.

Full text

Abstract:

The Notch signalling pathway is important in development and differentiation of a diverse range of both embryonic and adult tissues. There is now strong evidence implicating aberrant Notch signalling in the pathogenesis of T-cell acute lymphoblastic leukaemia (T-ALL), with over 50% of paediatric patients having activating mutations in NOTCH-1. This thesis aims to explore several aspects of the Notch pathway in both T-ALL and acute myeloid leukaemia (AML). Chapter one summarises the published data on the Notch signalling pathway itself, addressing the basic understanding of Notch activation thr

APA, Harvard, Vancouver, ISO, and other styles

23

Gianella-Borradori, Matteo Luca. "The identification & optimisation of endogenous signalling pathway modulators." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:4c87de5d-24a7-4998-8edb-917c3922aae1.

Full text

Abstract:

<strong>Chapter 1</strong> Provides an overview of drug discovery with particular emphasis on library selection and hit identification methods using virtual based approaches. <strong>Chapter 2</strong> Gives an outline of the bone morphogenetic protein (BMP) signalling pathway and literature BMP pathway modulators. The association between the regulation of BMP pathway and cardiomyogenesis is also described. <strong>Chapter 3</strong> Describes the use of ligand based virtual screening to discover small molecule activators of the BMP signalling pathway. A robust cell based BMP responsive gene a

APA, Harvard, Vancouver, ISO, and other styles

24

Albukhari, Ashwag. "Targeting EGFR signalling pathway in triple negative breast cancer." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:85d4bb10-385e-4187-8576-cf04f15f2871.

Full text

Abstract:

Epidermal growth factor receptor (EGFR) is frequently overexpressed in the majority of triple negative breast cancer patients (TNBC). However, the molecular determinants behind their limited response to EGFR-targeted therapies are poorly understood. Here, both the acute and chronic responses of TNBC to the EGFR-targeted therapy, cetuximab (CTX), have been investigated. The expression of EGFR has been analyzed in a cohort of 2000 breast cancer tumours from the public dataset as well as in a panel of breast cancer cell lines. Furthermore, the response of TNBC cell lines to CTX has been investiga

APA, Harvard, Vancouver, ISO, and other styles

25

Dandapani, Madhumita. "The AMPK signalling pathway in cancer and DNA damage." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/9a3ca91b-dd8b-4407-bed2-cd9dd4c00ca7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Whalen, Daniel M. "Structural and functional studies of the hedgehog signalling pathway." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ce0e765c-04f1-4a64-a67b-89204ecaa155.

Full text

Abstract:

Hedgehog (Hh) morphogens play fundamental roles in development whilst dysregulation of Hh signalling leads to disease. Multiple receptors are involved in the modulation of Hh morphogens at the cell surface. Among these, the interactions of Hh ligands with glycosaminoglycan (GAG) (for example heparan or chondroitin sulphate) chains of proteoglycans in the extracellular matrix play a key role in shaping morphogen gradients and fulfil important functions in signal transduction. Several high resolution crystal structures of Sonic Hh (Shh)-GAG complexes have been determined. The interaction determi

APA, Harvard, Vancouver, ISO, and other styles

27

Shewell, Lucy. "Characterisation of the Chemotaxis Signalling Pathway of Campylobacter Jejuni." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/365435.

Full text

Abstract:

Campylobacter jejuni colonizes the intestinal mucosa of all food-producing animals and humans (Newell & Fearnley, 2003) and is the leading cause of human bacterial gastroenteritis worldwide (Blaser, 1997; Friedman et al., 2000). It is unclear exactly how C. jejuni induces disease outcome in humans, however, a number of factors have been implicated in the pathogenesis of this organism, including colonization and adherence, invasion and translocation, toxin production, LOS and capsule structures, flagella and motility, protein glycosylation and chemotaxis. Chemotactic behaviour has been demonstr

APA, Harvard, Vancouver, ISO, and other styles

28

Willis, Miranda Jane. "Prostate cancer : the significance of the cAMP signalling pathway." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5410/.

Full text

Abstract:

Prostate cancer is the leading form of male cancer in western countries. However, despite a great deal of interest from the scientific community, the cause still remains elusive. What is clear, is that androgenic signalling is important within prostate cancer progression, with early cancer under androgenic control and androgen regulated genes, such as PSA, commonly used for patient prognosis and progression. 3',5'- cyclic adenosine monophosphate (cAMP) is an important second messenger signalling molecule, which has been extensively studied within the field of oncogenesis. cAMP signalling effec

APA, Harvard, Vancouver, ISO, and other styles

29

Han, Pingping. "Regulation of canonical Wnt signalling pathway during cementum regeneration." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/75652/1/Pingping_Han_Thesis.pdf.

Full text

Abstract:

This project highlights the important role of cell signalling pathway during tooth regeneration. Biomaterials can be designed to activate relevant cell signals for the purpose of dental repair and tooth regeneration. Based on the results in the present project, strategies directly targeting cell signalling pathway may provide new approaches for periodontal regenerative tissue engineering.

APA, Harvard, Vancouver, ISO, and other styles

30

Shao, Jin. "Notch signalling pathway regulates the terminal differentiation of osteoblasts." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/119172/2/Jin_Shao_Thesis.pdf.

Full text

Abstract:

This project contributes to our understanding of bone cell biology and sheds light on the potential therapeutic application of Notch signalling pathway on bone-related diseases. The thesis was a step forward in answering how bone cells communicate with each other and determinate their own fates. It provides the first evidence demonstrating Notch signalling is critical in bone cell functions.

APA, Harvard, Vancouver, ISO, and other styles

31

Leal, Cervantes Ana Irene. "Transcriptional consequences of Jak-Stat signalling in haematopoiesis." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709253.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Moleirinho, Susana. "Mammalian upstream Hippo signalling pathway proteins activate core pathway kinases and functionally antagonize oncogenic YAP." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/3662.

Full text

Abstract:

The mechanism of body and organ size control is an unsolved puzzle. Initially characterized in Drosophila melanogaster, the Salvador/Warts/Hippo (Hippo) signalling pathway, highly conserved throughout evolution, defines a novel signalling cascade regulating cell contact inhibition, organ size control, cell growth, proliferation, apoptosis, and cancer development in mammals. The upstream regulation of this pathway has been less well defined than the core kinase cassette. Previously Willin/FRMD6 has been proposed as the human orthologue of Expanded and, to date, little is known about the functio

APA, Harvard, Vancouver, ISO, and other styles

33

Fletcher, Claire E. "Interactions of microRNA27a and prohibitin in the androgen signalling pathway." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/39828.

Full text

Abstract:

Prohibitin (PHB) is a highly conserved, multi-functional protein that acts as a tumour suppressor and androgen receptor (AR) corepressor. We found that downregulation of PHB by androgens is required to drive androgen-dependent prostate cancer cell growth. This effect can be mimicked through the use of PHB siRNA, whereby reduction in PHB protein levels enhances cancer cell and xenograft tumour growth. Conversely, PHB overexpression results in rapid accumulation of prostate cancer cells in G0/G1. The potential importance of PHB in prostate cancer development merits investigations into possible a

APA, Harvard, Vancouver, ISO, and other styles

34

Zhong, Silin. "Protein localization and interactions in the tomato ethylene signalling pathway." Thesis, University of Nottingham, 2007. http://eprints.nottingham.ac.uk/10405/.

Full text

Abstract:

Early studies of the tomato ethylene signalling network using yeast two-hybrid screen previously identified three novel proteins (IntCR22, 242 and 266) that could interact with a putative ethylene kinase LeCTR2 (Lin et al., 2003). In this study, it has been demonstrated that IntCR22 is a cytoplasmic UDP-glycosyltransferase and IntCR266 is a chloroplast metallo-proteinase homologue to the Arabidopsis FtSH5/VAR1, whereas IntCR242 encodes a novel chloroplast protein with a C-terminal histidine-rich domain. In order to gain more insight into the tomato ethylene signalling mechanism, the sub-cellul

APA, Harvard, Vancouver, ISO, and other styles

35

Lees, Charles William. "Role of the hedgehog signalling pathway in inflammatory bowel disease." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4233.

Full text

Abstract:

Introduction. The inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), are common in Western Europe (200-400 cases /100,000) and associated with substantial morbidity, although mortality is now low. There is presently a great unmet need for novel therapeutics in IBD as present agents are limited by lack of efficacy, toxicity and poor patient acceptance. Recent findings from genome-wide association studies (GWAS) have characterised the genetic architecture of CD and UC. Defects in innate and adaptive immunity have been clearly established, and substantial novel i

APA, Harvard, Vancouver, ISO, and other styles

36

Lu, W. "Characterisation of CCN3 signalling pathway in Chronic Myeloid Leukaemia (CML)." Thesis, Queen's University Belfast, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517404.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Blessie, Victor. "Characterisation of the VicK-VicR signalling pathway in Enterococcus faecalis." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502778.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Hutchinson, Lisa. "Biochemical analysis of components of the wingless/WNT signalling pathway." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395976.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Inman, Louise. "The c-Kit signalling pathway and acute non-lymphoblastic leukaemogenesis." Thesis, University of the West of England, Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365066.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Thomas, Chloe. "An analysis of the Hh signalling pathway in Drosophila melanogaster." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398384.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Hudson, Martin. "The nitric oxide - guanylate cyclase signalling pathway in Caenorhabditis elegans." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287267.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Frost, Julianty. "VHL inhibitors as chemical probes of the hypoxia signalling pathway." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/2885a480-4372-426c-8cab-45b74d1a5b7e.

Full text

Abstract:

Von Hippel–Lindau (VHL) is the E3 ubiquitin ligase targeting hypoxia-inducible transcription factor-alpha (HIF α) for proteasomal degradation. The crucial function of VHL in response to hypoxia and cellular oxygen sensing are well established, owing to the use of genetic tools through knockout and knockdown that inactivate VHL. However, the functional consequences of specifically interrupting the interaction between VHL and HIF α remain to be elucidated. The development of a chemical probe that unambiguously blocks the VHL:HIF α interaction downstream of HIF α hydroxylation by prolyl hydroxyla

APA, Harvard, Vancouver, ISO, and other styles

43

Huang, Caoxin. "Notch signalling pathway in murine embryonic stem cell derived haematopoiesis." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8071.

Full text

Abstract:

Haematopoiesis is the process to produce haematopoietic stem cells (HSCs), haematopoietic progenitors (HPCs) and terminally differentiated cell types. In the adult, HSCs resided in bone marrow while in the embryo, haematopoiesis occurred sequentially in several niches including yolk sac, aorta-gonad-mesonephros (AGM) region, placenta and fetal liver. The AGM region is the first place where HSCs arise in vivo and therefore should provide important factors to induce haematopoiesis. The mouse embryonic stem cells (mESC) system is a powerful platform to mimic the development process in vitro and i

APA, Harvard, Vancouver, ISO, and other styles

44

Sammler, Esther. "Signalling pathway of FBXO7 and its role in hereditary Parkinsonism." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/2a2889b3-20b5-4353-af11-72782c07ef3a.

Full text

Abstract:

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s and old age is the strongest risk factor for developing PD. PD has traditionally been seen as a motor disorder, but its non-motor symptoms such as dysautonomia, sensory dysfunction, sleeping problems and neuropsychiatric features equally add to the disease burden. There is no cure for PD and this is probably a reflection of our poor understanding of the disease pathogenesis. One way of tackling this is to focus on the small, but significant number of PD patients with a family history compatible with

APA, Harvard, Vancouver, ISO, and other styles

45

Nunes, Ana Rita Silva Martins. "O2/CO2-sensitive cyclic AMP-signalling pathway in peripheral chemoreceptors." Doctoral thesis, Faculdade de Ciências Médicas. UNL, 2013. http://hdl.handle.net/10362/9153.

Full text

Abstract:

RESUMO: O corpo carotídeo (CB) é um pequeno órgão sensível a variações na PaO2, PaCO2 e pH. As células tipo I (células glómicas) do corpo carotídeo, as unidades sensoriais deste órgão, libertam neurotransmissores em resposta às variações dos gases arteriais. Estes neurotransmissores atuam quer em recetores pré-sinápticos, localizados nas células tipo I, quer em recetores póssinápticos, localizados nas terminações do nervo do seio carotídeo, ou em ambos. A activação dos recetores pré-sinápticos modula a atividade do corpo carotídeo, enquanto que, a activação dos recetores pós-sinápticos, de

APA, Harvard, Vancouver, ISO, and other styles

46

Apostoli, Georgina Lorraine. "Targeting the nitric oxide signalling pathway to modulate platelet function." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44082.

Full text

Abstract:

Nitric oxide (NO) negatively regulates platelets and impaired NO signalling can lead to arterial thrombosis. The source of platelet-derived NO is unclear with recent proposals of NO synthase (NOS) independent NO sources, such as S-nitrosothiols (RSNOs) and inorganic nitrate/nitrite. Sildenafil citrate, a phosphodiesterase 5 (PDE5) inhibitor, enhances NO/cGMP signals in cells expressing PDE5 such as platelets. The aims of this study were to investigate the antiplatelet properties of sildenafil, its mechanism of action and to determine the upstream sources of NO affecting platelet function. The

APA, Harvard, Vancouver, ISO, and other styles

47

Salgueiro, Manuel Pedro. "Lgr5 stem cells and Wnt signalling pathway in gastric cancer." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/7182/.

Full text

Abstract:

Gastric cancer (GC) is the 4th most common cancer in the world. Although there is lots of information on the factors that cause GC such as Helicobacter pylori there is still much to learn about gastric carcinogenesis. In this thesis I aimed to develop: 1) Lgr5 antibodies to identify gastric stem cell and potential cancer stem cell populations. 2) New models of gastric cancer that might offer new insights into the cell of origin of gastric cancer and disease pathogenesis. The Wnt target gene LGR5/GPR49 (Leucine-rich repeat-containing G protein-coupled receptor 5) is a specific marker for stem c

APA, Harvard, Vancouver, ISO, and other styles

48

Sinha, Tanay Kumar. "Validation and optimization of multiplexInSitu PLA for signalling pathway analysis." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450392.

Full text

Abstract:

With the advent of Tyrosine kinase inhibitors (TKI) as a therapy for Chronic myeloid Leukemia (CML), the patients now enjoy a life expectancy close to that of the general population. But some patients do get unresponsive to the TKI treatment over time due to several mutations in the kinase domain of the BCR-ABL fusion protein, which further leads to activation of multiple signaling cascades within the leukemic cell, helping it survive and proliferate. This project validates and optimizes a new method of In situ PLA that incorporates the usage of different padlocks and template oligos. Multiple

APA, Harvard, Vancouver, ISO, and other styles

49

Vitellozzi, Lucia. "Studies towards steroidal modulators of the Hedgehog/Gli signalling pathway." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/7624/.

Full text

Abstract:

The modern age faces a progressive lengthening of life span, which is often associated with the onset of degenerative disorders such as Parkinson’s, Alzheimer’s and cancer. These diseases do not yet have a cure. The Hedgehog/Gli signalling pathway is one of the most promising pathways of cellular communication. Pharmacological modulation of this pathway would provide a remarkable approach for new potential therapeutics in regenerative medicine and cancer. Attention was focussed on coagulin L and withanolide F, two natural steroidal lactones featuring interesting reactive functionalities. The a

APA, Harvard, Vancouver, ISO, and other styles

50

Kalymbetov, Anuar [Verfasser]. "Role of JAK/STAT signalling pathway in PAH / Anuar Kalymbetov." Gießen : Universitätsbibliothek, 2016. http://d-nb.info/1120270227/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!