Relevant bibliographies by topics / Toxoid

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Toxoid'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Toxoid"

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Ruan, Xiaosai, Donald C. Robertson, James P. Nataro, John D. Clements, and Weiping Zhang. "Characterization of Heat-Stable (STa) Toxoids of Enterotoxigenic Escherichia coli Fused to Double Mutant Heat-Labile Toxin Peptide in Inducing Neutralizing Anti-STa Antibodies." Infection and Immunity 82, no. 5 (2014): 1823–32. http://dx.doi.org/10.1128/iai.01394-13.

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ABSTRACTA long-standing challenge in developing vaccines against enterotoxigenicEscherichia coli(ETEC), the most common bacteria causing diarrhea in children of developing countries and travelers to these countries, is to protect against heat-stable toxin type Ib (STa or hSTa). STa and heat-labile toxin (LT) are virulence determinants in ETEC diarrhea. LT antigens are often used in vaccine development, but STa has not been included because of its poor immunogenicity and potent toxicity. Toxic STa is not safe for vaccines, but only STa possessing toxicity is believed to be able to induce neutra
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Polvani, C., A. Gasparini, U. Benatti, et al. "Murine red blood cells as efficient carriers of three bacterial antigens for the production of specific and neutralizing antibodies." Biotechnology and Applied Biochemistry 14, no. 3 (1991): 347–56. http://dx.doi.org/10.1111/j.1470-8744.1991.tb00187.x.

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Three bacterial toxoids, CRM 197 (mutagenized diphtheria toxin), tetanus toxoid (formaldehyde‐treated tetanus toxin), and PT‐9K/129G (double mutant of pertussin toxin) were encapsulated within red blood cells (RBCs) of B6D2F1 and Balb/C mice according to a mild procedure based on hypotonic dialysis‐isotonic resealing that yielded undamaged RBCs. The toxoid‐loaded RBCs were injected intravenously in order to immunize animals and their effects were compared to those of identical amounts (30–95 micrograms per mouse subdivided into multiple injections) of the corresponding free toxoids injected in
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Zhang, Weiping, Chengxian Zhang, David H. Francis, et al. "Genetic Fusions of Heat-Labile (LT) and Heat-Stable (ST) Toxoids of Porcine Enterotoxigenic Escherichia coli Elicit Neutralizing Anti-LT and Anti-STa antibodies." Infection and Immunity 78, no. 1 (2009): 316–25. http://dx.doi.org/10.1128/iai.00497-09.

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ABSTRACT Enterotoxigenic Escherichia coli (ETEC) strains are a major cause of diarrheal disease in humans and farm animals. E. coli fimbriae, or colonization factor antigens (CFAs), and enterotoxins, including heat-labile enterotoxins (LT) and heat-stable enterotoxins (ST), are the key virulence factors in ETEC diarrhea. Unlike fimbriae or LT, STa has not often been included as an antigen in development of vaccines against ETEC diarrhea because of its poor immunogenicity. STa becomes immunogenic only after being coupled with a strongly immunogenic carrier protein. However, native or shorter ST
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Rahman M, S., K. Baek B, T. Hong S, and H. Lee J. "Antibody responses in buffalos immunized with Clostridium perfringens beta and epsilon toxoids." Veterinární Medicína 46, No. 9–10 (2001): 241–43. http://dx.doi.org/10.17221/7886-vetmed.

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The antibody responses to toxoids were measured to investigate whether Clostridium perfringens beta and epsilon toxoids induced protective humoral immune responses in buffalos. Total of 24 buffalos were divided into 4 groups (n = 6), beta toxoid, epsilon toxoid, combination and control groups. These buffalo groups were administered each of the designated toxoids. Immunizations in the beta and epsilon toxoid groups induced strong antibody responses. The neutralizing antibody titres from the beta and epsilon toxoid groups were equally log101.2 on day 21 after inoculati
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Keller, James E. "Characterization of New Formalin-Detoxified Botulinum Neurotoxin Toxoids." Clinical and Vaccine Immunology 15, no. 9 (2008): 1374–79. http://dx.doi.org/10.1128/cvi.00117-08.

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ABSTRACT Antigenicities of several formalin-detoxified botulinum neurotoxin preparations were measured by inhibition and sandwich enzyme-linked immunosorbent assay (ELISA), and immunogenicity was studied in mice. The toxoids were derived primarily from the serotype A 150-kDa neurotoxin protein, while one toxoid was derived from the naturally occurring 900-kDa toxin-hemagglutinin complex. Antigenicity was severely compromised in two commercially available toxoids. A variety of new toxoids were synthesized in-house by optimizing formaldehyde reaction conditions. Three of the resulting toxoids we
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Komarovskaya, E. I., and O. V. Perelygyna. "Current state of methods for control the safety and potency of diphtheria toxoid and tetanus toxoid in combined vaccines." Epidemiology and Vaccinal Prevention 21, no. 3 (2022): 96–106. http://dx.doi.org/10.31631/2073-3046-2022-21-3-96-106.

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Relevance. Diphtheria toxoid (DT) and tetanus toxoid (TT) manufacturing appears as many steps process. On every stage of proceeding vaccine the control of critical points is being provided. The Parke Williams 8 strain of Corynebacterium diphtheriae used in Russia for producing DT, Clostridium tetani strain Harvard – for TT. Each culture's supernatant proceed being estimated in relevance of toxoid potency via in vivo and/or in vitro methods. To produce DT, the activity of the toxoid must be not less than 50 Lf/ml and 40 Lf/ml for TT. Toxoids must fit in the main safety conditions – absence of t
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Komarovskaya, E. I., and О. V. Perelygyna. "Assay of Diphtheria Vaccine Potency by Intradermal Challenge Test." Epidemiology and Vaccinal Prevention 22, no. 4 (2023): 12–23. http://dx.doi.org/10.31631/2073-3046-2023-22-4-12-23.

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Relevance. Modern identifying potency (immunogenicity) of diphtheria toxoid tests are based on determining immunized animals resistance for administration challenge toxin or evaluation of protective antibodies level in serum. In Russia to assess the potency of diphtheria toxoid (DT) the challenge lethal method has been used for more than 60 years, challenge is based on determination of potency via its possibility to defend immunized animals from lethal doses of diphtheria toxin. This method is used as «golden standard». Last decade European Union Regulatory politic is headed to reduce of using
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Held, Daniel M., Amy C. Shurtleff, Scott Fields, et al. "Vaccination of Rabbits with an Alkylated Toxoid Rapidly Elicits Potent Neutralizing Antibodies against Botulinum Neurotoxin Serotype B." Clinical and Vaccine Immunology 17, no. 6 (2010): 930–36. http://dx.doi.org/10.1128/cvi.00493-09.

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ABSTRACT New Zealand White (NZW) rabbits were immunized with several different nontoxic botulinum neurotoxin serotype B (BoNT/B) preparations in an effort to optimize the production of a rapid and highly potent, effective neutralizing antibody response. The immunogens included a recombinant heavy chain (rHc) protein produced in Escherichia coli, a commercially available formaldehyde-inactivated toxoid, and an alkylated toxoid produced by urea-iodoacetamide inactivation of the purified active toxin. All three immunogens elicited an antibody response to BoNT/B, detected by enzyme-linked immunoso
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Bernstein, Henry H., Edward P. Rothstein, Sarah S. Long, et al. "Comparison of a Three-Component Acellular Pertussis Vaccine With a Whole-Cell Pertussis Vaccine in 15- Through 20-Month-Old Infants." Pediatrics 93, no. 4 (1994): 656–59. http://dx.doi.org/10.1542/peds.93.4.656.

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Objective. To compare the immunogenicity and reactogenicity of a diphtheria and tetanus toxoids and three-component acellular pertussis vaccine (DTaP) with a diphtheria and tetanus toxoids and whole-cell pertussis vaccine (DTwP) when administered as a booster dose to infants 15 through 20 months of age. Design. Randomized, double-blind, comparative study. Setting. Three pediatric practices (two private; one hospital-based). Participants. One hundred and sixty-five healthy 15-through 20-month old infants. Selection procedures and interventions. Infants were randomly assigned in a 2:1 ratio to r
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Nijland, Reindert, René Heerlien, Leendert W. Hamoen та Oscar P. Kuipers. "Changing a Single Amino Acid in Clostridium perfringens β-Toxin Affects the Efficiency of Heterologous Secretion by Bacillus subtilis". Applied and Environmental Microbiology 73, № 5 (2007): 1586–93. http://dx.doi.org/10.1128/aem.02356-06.

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ABSTRACT Achieving efficient heterologous protein production and secretion by Bacillus subtilis is an attractive prospect, although often disappointingly low yields are reached. The expression of detoxified Clostridium perfringens β-toxin (β-toxoid) is exemplary for this. Although β-toxin can be efficiently expressed and secreted by Bacillus subtilis, the genetically detoxified, and industrially interesting, β-toxoid variant is difficult to obtain in high amounts. To optimize the expression of this putative vaccine component, we studied the differences in the global gene regulation responses o
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Dissertations / Theses on the topic "Toxoid"

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Michaelides, Alecos. "Chemical and enzymatic fragmentation of tetanus toxin and immunological studies on anti-tetanus toxin and toxoid sera." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/9661.

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This thesis describes the immunization protocols for the production of antibodies against tetanus toxin and toxoid in guinea pigs and mice. Antibodies were successfully raised against the toxin without mortalities in either species. The murine sera obtained, were isotyped by ELISA and the toxin was proven to be a superior antigen in eliciting production of IgG$\rm\sb{2a}$ and IgG$\sb3$. The two isotypes which have demonstrated antitumor activity. The anti-toxoid sera exhibited a lower reactivity towards the toxin and toxoid when compared with anti-toxin sera. The reactivity of recombinant teta
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Sheppard, A. J. "Studies on production and characterisation of monoclonal antibodies to tetanus toxin, and their use for developing immunopurified tetanus toxoid and toxin." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235280.

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Nijland, Reindert. "Heterologous expression and secretion of Clostridium perfringens [beta]-toxoid by Bacillus subtilis." [S.l. : Groningen : s.n. ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/301153868.

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Каплін, Микола Микитович, Николай Никитович Каплин, Mykola Mykytovych Kaplin, Artem Mykhailovych Piddubnyi, Артем Михайлович Поддубный та Артем Михайлович Піддубний. "Динаміка антитоксичного імунітету у донорів, імунізованих стафілококовим анатоксином". Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27043.

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З метою профілактики та лікування важких гнійно-запальних захворювань стафілококової етіології в медичній практиці використовують гіперімунну антистафілококову плазму та специфічний імуноглобулін. Ці препарати отримують шляхом імунізації донорів стафілококовим анатоксином. Ось чому вплив різних факторів на рівень імунної відповіді є одою із важливих проблем сучасної імунології. Дані відносно впливу групи крові на рівень антитоксичного імунітету в літературі мало чисельні та суперечливі. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/27043
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Harrington, Noel P. "Suppression of murine splenic mononuclear cell response to mitogen by irradiation and tetanus toxoid: A study of possible mechanisms." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/6528.

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This study examines the possible mechanisms by which radiation and the bacterial toxin, Tetanus toxoid (TT), suppress the murine splenic mononuclear cell (SMNC) response to mitogen. This study demonstrates that the lymphocyte proliferation response of SMNC to the mitogenic lectin PHA can be suppressed by TT in a dose-dependant manner in vitro, without affecting the viability of the cells, in the anti-proliferative concentrations used (0.5-5 $\mu$g/ml). SMNC pre-incubated with TT could suppress the pHA blastogenic response of fresh autologous cells during co-incubation suggestion the involvemen
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Stefanovic, Helen. "Suppression of human peripheral blood mononuclear cell response to mitogen by tetanus toxoid. A study of the possible mechanisms." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7603.

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Previous studies have shown that certain antigens can down-regulate immune responses of human peripheral blood mononuclear cells (PBMC) both in vivo and in vitro. This study demonstrates that tetanus toxoid (TT), in a dose-dependent fashion, suppresses the induction of a blastogenic response of PBMC by phytohemagglutinin (PHA), monoclonal anti-CD3, and anti-CD4 antibody. Pokeweed mitogen (PWM)-induction of IgG and IgM is suppressed as well. The suppression is partially reversed by indomethacin and IL-2, but not by IL-1 or tumor necrosis factor (TNF-$\alpha$). PBMC pre-incubated with TT could s
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Bartels, Britta Marlen [Verfasser], and Carsten [Akademischer Betreuer] Bokemeyer. "Erfassung von Tetanus-Toxoid- und Influenza-Nukleoprotein-spezifischen Antikörpern bei Patienten mit multiplem Myelom / Britta Marlen Bartels. Betreuer: Carsten Bokemeyer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2012. http://d-nb.info/1021499935/34.

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Gatsos, Xenia, and xgatsos@optusnet com au. "The development of live vectored vaccines targeting the alpha-toxin of Clostridium perfringens for the prevention of necrotic enteritis in poultry." RMIT University. Applied Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080212.142403.

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The Ą-toxin of Clostridium perfringens is a toxin involved in numerous diseases of humans and agriculturally important animals. One of these diseases is necrotic enteritis (NE), a sporadic enteric disease which affects avian species world-wide. This study involved the inactivation of alpha-toxin (Ą-toxin) for use as a potential vaccine candidate to combat NE in chickens, and other diseases caused by C. perfringens type A. During the course of this research a number of Ą-toxin recombinant proteins were developed through molecular inactivation of the Ą-toxin gene, plc. Proteins plc3
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Rescia, Vanessa Cristina [UNIFESP]. "REVs-Chi: um novo sistema particulado para encapsulação de macromoléculas terapêuticas." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/10065.

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Made available in DSpace on 2015-07-22T20:50:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-07-29<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A quitosana (Chi), a (1-4)-amino-2-desoxi-ƒÒ-glicana, e a forma desacetilada da quitina, um polissacarideo das conchas de crustaceos. As suas caracteristicas unicas como a carga positiva, biodegradabilidade, biocompatibilidade, atoxicidade e estrutura rigida fazem com que esta
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Nass, Shafique Sani. "Evaluation of Active and Passive Neonatal Tetanus Surveillance Systems in Katsina State, Nigeria." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2095.

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The incidence and mortality rates of neonatal tetanus (NNT) remain underreported in Nigeria. This cross-sectional study was guided by the Mosley and Chen's model for the elements of child survival in developing countries. The goals of the study were twofold: (a) to compare the NNT prevalence and the mortality rates from the existing surveillance system and active surveillance of health facility records in 7 selected health facilities from 2010 to 2014 in Katsina state, Nigeria and (b) to assess the associations between selected NNT risk factors, number of maternal tetanus toxoid injections, fr
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Books on the topic "Toxoid"

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UNICEF, ed. Accelerated tetanus toxoid programme in North West Frontier Province, Pakistan. UNICEF, 1988.

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Inmunización, Programa Ampliado de, Pan American Health Organization, and World Health Organization, eds. Neonatal tetanus elimination field guide. The Organization, 1993.

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Bergdoll, Merlin S. Toxic shock syndrome. CRC Press, 1991.

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author, Smith Rick 1968, ed. Toxin toxout: Getting harmful chemicals out of our bodies and our world. Vintage Canada, 2014.

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Robin, Cook. Toxin. Putnam, 1998.

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Robin, Cook. Toxin. Berkley Books, 1999.

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Lynch, Maryanne. Toxic. Playlab Press, 2001.

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Maggi, Marcos. Toxon. Botella al Mar, 2001.

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Robin, Cook. Toxin. BCA, 1998.

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Robin, Cook. Toxin. Berkley Books, 1999.

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Book chapters on the topic "Toxoid"

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Gooch, Jan W. "Toxoid." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_14985.

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Grabenstein, John D. "Toxoid Vaccines." In Vaccines: A Biography. Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-1108-7_7.

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Renz, H., and B. Gierten. "Impfantikörper gegen Tetanus-Toxoid." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_1560-1.

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Renz, H., and B. Gierten. "Impfantikörper gegen Tetanus-Toxoid." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_1560.

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Corradin, G., and C. Watts. "Cellular Immunology of Tetanus Toxoid." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-85173-5_4.

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Burnette, W. Neal. "Perspectives in Recombinant Pertussis Toxoid Development." In Vaccine Research and Development. CRC Press, 2024. http://dx.doi.org/10.1201/9781003573838-8.

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Burnette, W. Neal. "Parameters for the Rational Design of Genetic Toxoid Vaccines." In Advances in Experimental Medicine and Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-1382-1_9.

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Gürser, Mayda, and Gregory Gregoriadis. "Interleukin-2 as a Co-Adjuvant for Liposomal Tetanus Toxoid." In Vaccines. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4613-0357-2_5.

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Cutiño-Avila, B., E. Cunill-Semanat, D. F. Gil, M. A. Chávez, J. Díaz, and A. del Monte-Martínez. "Synthesis of Tetanus Toxoid-Sepharose CL 4B derivatives by Rational Design." In V Latin American Congress on Biomedical Engineering CLAIB 2011 May 16-21, 2011, Habana, Cuba. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-21198-0_41.

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Pierce, Nathaniel F. "Intestinal Immunization with Soluble Bacterial Antigens: the Example of Cholera Toxoid." In Novartis Foundation Symposia. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720240.ch8.

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Conference papers on the topic "Toxoid"

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Soudi, Mahdi, Pablo Cencillo-Abad, and Debashis Chanda. "Ultralight Non-Toxic Plasmonic Paint." In CLEO: Fundamental Science. Optica Publishing Group, 2024. http://dx.doi.org/10.1364/cleo_fs.2024.fth4l.6.

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Traditional pigment-based colors suffer from instability and toxicity. Introducing a self-assembled subwavelength plasmonic cavity, we offer a scalable and environmentally friendly platform for vivid structural colors, providing stand-alone paints that are the lightest in the world.
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Venugopal, N. L. V., P. Kanchanamala, Satish Muppidi, T. Bhanu Prakash, T. Neelima, and S. Anjali Devi. "Multilingual Toxic Comment Classification using Deep Learning." In 2024 2nd International Conference on Self Sustainable Artificial Intelligence Systems (ICSSAS). IEEE, 2024. https://doi.org/10.1109/icssas64001.2024.10760913.

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Ferreira, Camila G., Ta^nia M. Avalloni, Yoko Oshima-Franco, et al. "Irradiation of the Crude Venom of Bothrops jararacussu to Obtain Toxoid." In XXXIII BRAZILIAN WORKSHOP ON NUCLEAR PHYSICS. AIP, 2011. http://dx.doi.org/10.1063/1.3608972.

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Fedosieieva, O. V. "Prenatal antigenic influence of staphylococcal toxoid into the thyroid gland morphogenesis." In MODERN MEDICINE: THE USE OF CREATIVE INDUSTRIES IN THE HEALTHCARE SYSTEM. Baltija Publishing, 2021. http://dx.doi.org/10.30525/978-9934-26-182-4-26.

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Yumafita, Tiara, Setyo Sri Rahardjo, and Rita Benya Adriani. "Path Analysis on Factors Associated with Tetanus Toxoid Immunization Utilization among Pregnant Women." In The 5th International Conference on Public Health 2019. Masters Program in Public Health, Universitas Sebelas Maret, 2019. http://dx.doi.org/10.26911/theicph.2019.03.17.

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Corrêa, Izabella, Rayane Marques, Renata Bastos, Patrícia Jurgilas, and Hilton Nascimento. "Molecular characterization of tetanus toxoid used in conjugate vaccines produced by Bio-Manguinhos - FIOCRUZ." In VI Seminário Anual Científico e Tecnológico. Instituto de Tecnologia em Imunobiológicos, 2018. http://dx.doi.org/10.35259/isi.sact.2018_26969.

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Corrêa, Marilza, Hilton Nascimento, Patrícia Jurgilas, et al. "LC-MS/MS as a tool for analysis of underivatized glutamic and aspartic amino acids residues from tetanus toxoid." In III Seminário Anual Científico e Tecnológico de Bio-Manguinhos. Instituto de Tecnologia em Imunobiológicos, 2015. http://dx.doi.org/10.35259/isi.sact.2015_28601.

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Ondei, Roberta, Caroline Dohanik, Leandro Oliveira, et al. "EmulsivantTM 70 as a novel chemistry for oil-based vaccines: pre-clinical and safety studies in tetanus toxoid model." In International Symposium on Immunobiological. Instituto de Tecnologia em Imunobiológicos, 2024. http://dx.doi.org/10.35259/isi.biomang.2024_63958.

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Bansal, Vivek, Manu Dalela, Manoj Kumar, H. G. Brahmne, and Harpal Singh. "Evaluation of effectiveness of polymeric nanoparticles based vaccine delivery system over varying time intervals using tetanus toxoid as model antigen." In 2013 International Conference on Advanced Nanomaterials and Emerging Engineering Technologies (ICANMEET). IEEE, 2013. http://dx.doi.org/10.1109/icanmeet.2013.6609259.

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Fletcher, E., W. van Maren, R. Cordfunke, et al. "Abstract PR01: T cell responses to peptide-epitopes of choice can be boosted by immune complexes of circulating anti-tetanus toxoid antibodies." In Abstracts: Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 25-28, 2016; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6066.imm2016-pr01.

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Reports on the topic "Toxoid"

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Gurevitz, Michael, Michael E. Adams, Boaz Shaanan, et al. Interacting Domains of Anti-Insect Scorpion Toxins and their Sodium Channel Binding Sites: Structure, Cooperative Interactions with Agrochemicals, and Application. United States Department of Agriculture, 2001. http://dx.doi.org/10.32747/2001.7585190.bard.

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Integrated pest management in modern crop protection may combine chemical and biological insecticides, particularly due to the risks to the environment and livestock arising from the massive use of non-selective chemicals. Thus, there is a need for safer alternatives, which target insects more specifically. Scorpions produce anti-insect selective polypeptide toxins that are biodegradable and non-toxic to warm-blooded animals. Therefore, integration of these substances into insect pest control strategies is of major importance. Moreover, clarification of the molecular basis of this selectivity
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2

Gurevitz, Michael, Michael Adams, and Eliahu Zlotkin. Insect Specific Alpha Neurotoxins from Scorpion Venoms: Mode of Action and Structure-Function Relationships. United States Department of Agriculture, 1996. http://dx.doi.org/10.32747/1996.7613029.bard.

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This study was motivated by the need to develop new means and approaches to the design of future, environmentally-safe, insecticides. Utilization of anti-insect selective toxins from scorpion venoms and clarification of the molecular basis for their specificity, are a major focus in this project and may have an applicative value. Our study concentrated on the highly insecticidal toxin, LqhaIT, and was devoted to: (I) Characterization of the neuropharmacological and electrophysiological features of this toxin. (II) Establishment of a genetic system for studying structure/activity relationships
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3

Snell, Madison Michelle, Courtney Jean Pruitt, and Kelsey Leigh Forde Curran. Toxic Endpoint Analysis. Office of Scientific and Technical Information (OSTI), 2016. http://dx.doi.org/10.2172/1494357.

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4

Snell, Madison M., Courtney Jean Pruitt, and Kelsey Leigh Forde Curran. Toxic endpoint analysis. Office of Scientific and Technical Information (OSTI), 2015. http://dx.doi.org/10.2172/1222535.

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5

Ana Palcic, Ana Palcic. Are zeolites toxic? Experiment, 2018. http://dx.doi.org/10.18258/11299.

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Wilson, Amy, and Brian Fuchs. Toxic Cloud Defeat. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada471701.

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7

Wisniewski, Michael, Samir Droby, John Norelli, Dov Prusky, and Vera Hershkovitz. Genetic and transcriptomic analysis of postharvest decay resistance in Malus sieversii and the identification of pathogenicity effectors in Penicillium expansum. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597928.bard.

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Use of Lqh2 mutants (produced at TAU) and rNav1.2a mutants (produced at the US side) for identifying receptor site-3: Based on the fact that binding of scorpion alpha-toxins is voltage-dependent, which suggests toxin binding at the mobile voltage-sensing region, we analyzed which of the toxin bioactive domains (Core-domain or NC-domain) interacts with the DIV Gating-module of rNav1.2a. This analysis was based on the assumption that the dissociation of toxin mutants upon depolarization would vary from that of the unmodified toxin should the substitutions affect a site of interaction with the ch
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8

Olsen. L52073 Integrated Test Plan. Pipeline Research Council International, Inc. (PRCI), 2008. http://dx.doi.org/10.55274/r0011305.

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This report assimilates and interprets the large body of data generated under the Integrated Test Program (ITP), with particular emphasis on the investigation of formaldehyde formation in large bore natural gas engines. Formaldehyde is a toxic emission that is specifically troublesome for natural gas engines because it is a primary combustion intermediate. The US Environmental Protection Agency (EPA) is currently developing air toxic regulations for oil and gas production, as declared by the 1990 Clean Air Act Amendments. The EPA is scheduled to promulgate air toxic regulations for internal co
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9

Zlotkin, Eliahu, Shizuo G. Kamita, Nor Chejanovsky, and S. Maeda. Targeting of an Expressed Insect Selective Neurotoxin by its Recombinant Baculovirus: Pharmacokinetic and Pharmacodynamic Aspects. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7571354.bard.

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Objectives: 1) Clarification of the mode of potentiation of an expressed insect selective neurotoxin (AaIT) by its recombinant baculovirus. 2) In vitro formation and/or modification of neuroactive polypeptides for the design of new improved recombinant baculoviruses. Results: 1) A combined utilization of bioassays, LM-cytochemistry, the highly resolutive EM immunogold and electrical recording from the CNS of baculovirus and AaIT - expressing – recombinant baculovirus infected larvae it has been shown that the recombinant virus potentiates the effect of the toxin. Potentiation is achieved throu
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10

Gurevitz, Michael, Michael E. Adams, and Boaz Shaanan. Structural Elements and Neuropharmacological Features Involved in the Insecticidal Properties of an Alpha Scorpion Neurotoxin: A Multidisciplinary Approach. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7573061.bard.

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Integrated pest management in modern crop protection requires the use of chemical or biological insecticides in many instances. Nontheless, the use non-selective chemical insecticides poses risks to the environment and livestock and consequently urgent need exists for safer alternatives, which target insects more specifically. Scorpions produce anti-insect selective polypeptide toxins that are biodegradable and not toxic to wam-blooded animals. Therefore, mobilization of these substances into insect pest targets is of major interest. Moreover, clarification of the molecular basis of this selec
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