Relevant bibliographies by topics / Treatment resistance depression

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Treatment resistance depression'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Treatment resistance depression"

1

Kasper, S. "Treatment Resistance in Depression." European Psychiatry 26, S2 (2011): 2022. http://dx.doi.org/10.1016/s0924-9338(11)73725-7.

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Due to the advancement of antidepressant medication, more patients receive treatment in everyday practice, and response/remission is not achieved in the majority of the patients. Several attempts to validate the definition of treatment resistance have been undertaken and the criteria usually encompased to treatment sequences are that two different classes of antidepressants given in a sufficient dosage for a sufficient time have to be administered. Clinically, it is evident that this defintion does not include the treatment refractory patients which could be defined as not responding to numeru
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Karstensen, Valerie, Geoffrey Olsen, and Mathias Bastholm. "Understanding Treatment Resistance in Depression." KMAN Counseling and Psychology Nexus 2, no. 1 (2024): 63–69. https://doi.org/10.61838/kman.psynexus.2.1.10.

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Treatment-resistant depression (TRD) represents a significant challenge in psychiatric care, affecting a substantial portion of patients who do not respond to conventional treatment modalities. This qualitative study aims to explore the lived experiences of individuals diagnosed with TRD to better understand the personal, social, and systemic factors that contribute to treatment resistance and identify potential avenues for more effective interventions. The study utilized a qualitative design, conducting semi-structured interviews with 33 participants diagnosed with TRD. Data collection contin
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Karstensen, Valerie, Geoffrey Olsen, and Mathias Bastholm. "Understanding Treatment Resistance in Depression." KMAN Counseling and Psychology Nexus 2, no. 1 (2024): 63–69. http://dx.doi.org/10.61838/kman.psychnexus.2.1.10.

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Treatment-resistant depression (TRD) represents a significant challenge in psychiatric care, affecting a substantial portion of patients who do not respond to conventional treatment modalities. This qualitative study aims to explore the lived experiences of individuals diagnosed with TRD to better understand the personal, social, and systemic factors that contribute to treatment resistance and identify potential avenues for more effective interventions. The study utilized a qualitative design, conducting semi-structured interviews with 33 participants diagnosed with TRD. Data collection contin
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Cuijpers, Pim. "From treatment resistance to sequential treatments of depression." World Psychiatry 22, no. 3 (2023): 418–19. http://dx.doi.org/10.1002/wps.21138.

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Chaturvedi, Santosh K. "Treatment Resistance and Chronicity of Depression." Canadian Journal of Psychiatry 34, no. 5 (1989): 477. http://dx.doi.org/10.1177/070674378903400529.

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Millet, E., R. Icick, and J. P. Lépine. "Treatment-resistant depression: From pseudo-resistance to full resistance." European Psychiatry 26, S2 (2011): 638. http://dx.doi.org/10.1016/s0924-9338(11)72344-6.

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IntroductionTreatment-resistant depression (TRD) has been a controversial issue for more than 35 years. Despite a large number of publications, clinicians and researchers still know few about the prevalence of TRD since no staging method has been validated.ObjectivesWe sought to assess similarities and differences between the 4 TRD-staging methods published to date and assess TRD prevalence in a clinical sample. We also wanted to look for clinical factors associated with TRD.MethodsWe conducted a clinical study in a psychiatric unit of a university hospital. We designed a hetero-questionnaire
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Kelly, Cristina Nunes Silva, and Gisele Santos Maria. "Physiological benefits of resistance training in depressive persons: a literature review." International Journal of Medical Reviews and Case Reports 3, no. 4 (2019): 160–66. https://doi.org/10.5455/IJMRCR.PHYSIOLOGICALBENEFITS-OF-RESISTANCE-TRAINING.

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The current society, due to the technological advance, excessive collections, reigning individualism, among others, is faced with a significant increase of individuals with depression. Some authors conceptualize depression as a disease where the individual feels inferior to everything and everyone, with no capacity and willingness to face the challenges, because it presents a feeling of fear of failure, thus promoting a reduction of the feeling of pleasure, irritability, feelings of guilt and, in more serious cases, suicidal thoughts.The concept of depression is applied to a mood disorder, enc
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Rihmer, Z. "Treatment resistance in bipolar disorder." European Psychiatry 26, S2 (2011): 2025. http://dx.doi.org/10.1016/s0924-9338(11)73728-2.

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Antidepressant-resistant major depression (AD-RD) is a great challenge for the treating clinician. The most widely accepted definition of AD-RD refers that the depressed patient does not show a clinically significant response after at least two adequate trials of different classes of antidepressants. In spite of the fact that there are several causes of AD-RD in general, there is increasing evidence that one of the most common sources of it is the unrecognized bipolar nature of the “unipolar” major depressive episode, when the patients receive antidepressant monotherapy - unprotected by mood s
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Yunilayne, O. A., E. G. Starostina, and I. V. Oleichik. "Hypothalamo-Pituitary-Adrenal Axis in Depressive Disorders and Treatment Resistance." Psikhiatriya 21, no. 1 (2023): 73–90. http://dx.doi.org/10.30629/2618-6667-2023-21-1-73-90.

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Background: hypothalamo-pituitary-adrenal (HPA) axis plays an important role in the pathogenesis of depression. Patterns of HPA functioning depend on both biologic factors and psychological background, which, taken together, may increase the risk of depression later on. Objective: to analyze scientific publications on pathophysiology of depression, linked to HPA disruption, assess causal relationship between hypercorticism and depression, role of hypercorticism in clinical symptoms and course of depressive disorder.Material and methods: according to the key words “hypercortiсism”, “depression
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Khaustova, Olena. "Resistant depression: criteria for determination, risk factors and therapeutic strategies." Psychosomatic Medicine and General Practice 2, no. 3 (2017): 020338. http://dx.doi.org/10.26766/pmgp.v2i3.38.

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Background Therapy of resistant depression raises a number of diagnostic and therapeutic problems, requires the solution of a number of methodological issues. A scientific discussion continues around the definition of depression resistance, assessment of the degree of reduction of depressive symptoms, the level of social and role functioning of patients; the improvement of models for determining the degree of resistance to various types of depression therapy continues; new methods of therapy and new algorithms of combined therapy are being developed. The ultimate goal of all these efforts shou
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Dissertations / Theses on the topic "Treatment resistance depression"

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Draganov, Metodi. "Neurobiological factors associated with treatment response and resistance in Major Depression." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671083.

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La depressió és una malaltia heterogènia que afecta una part substancial de la població mundial en algun moment determinat de la seva vida. En els casos lleus, la gent pot sentir tristesa i apatia durant diversos dies per les coses que li agradava fer a la vida quotidiana, mentre que en els casos greus la persona pot necessitar una combinació d’antidepressius i psicoteràpia durant diversos anys. En aquests darrers casos, iniciar el tractament tard, per diversos factors com ara un diagnòstic poc clar, pot dificultar les possibilitats futures d’èxit. Fins el moment, el diagnòstic es basa en un e
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Garriock, Holly Ann. "Genetics of Major Depressive Disorder in Treatment Resistance and Tryptophan Depletion." Diss., Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1462%5F1%5Fm.pdf&type=application/pdf.

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de, la Salle Sara. "Electrophysiological Correlates and Predictors of the Antidepressant Response to Repeated Ketamine Infusions in Treatment-Resistant Depression." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41551.

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Traditional antidepressants, which act on the serotonin, dopamine, and norepinephrine systems, require many weeks to produce a therapeutic effect and are not effective for every patient. A sub-anesthetic dose of the anesthetic agent ketamine, a glutamate N-methyl-D-aspartate receptor antagonist, has been shown to produce a rapid and robust antidepressant effect in treatment-resistant major depressive disorder (MDD). As depressive symptoms typically return after one week following a single infusion, recent work has begun to focus on methods for prolonging the effects. Repeated infusions on a sp
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Kemp, David E. "Use of Insulin Sensitizers as a Novel Treatment for Major Depressive Disorder: A Pilot Study of Pioglitazone for Major Depression Accompanied by Abdominal Obesity." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1275567223.

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Rizzo, S. "Role of cytokines in treatment-resistant depression." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1387201/.

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The exact pathophysiology of major depressive disorder (MDD) has yet to be fully elucidated. The belief that depression is strictly a disorder of monoaminergic consequences is undergoing great reconsideration due to the lack of efficacy of the current pharmacotherapeutics. There is compelling clinical literature implicating a role for cytokines in the pathophysiology of MDD. IL-6 and IL-1β are pleiotropic inflammatory cytokines that have been reported to be elevated in patients with MDD. The present studies were undertaken to investigate the relationship between IL-6 and IL-1β in animal models
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Blom, Emma-Clara. "Ketamine for treatment-resistant depression : Moving away from conventional antidepressants." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20177.

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An increasing amount of research suggests Ketamine in subanaesthetic doses to be an effective antidepressant for Major Depressive Disorder (MDD) and Treatment-Resistant Disorder (TRD). After the finding that NMDA-receptor antagonists may hold antidepressant effect, several studies have suggested Ketamine to have great effect in relief of depressive symptoms. A time lag between biological and behavioural effects have been shown in currently available antidepressants and are not guaranteed to be efficient; only 30% of patients reach adequate response. The aim for this thesis is to systematically
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Wigmore, Eleanor May. "Regional brain volumes and antidepressant treatment resistance in major depressive disorder." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31291.

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Major depressive disorder (MDD) is a heritable and highly debilitating condition with antidepressants, first-line treatment, demonstrating low to modest response rates. No current biological mechanism substantially explains MDD but both neurostructural and neurochemical pathways have been suggested. Further explication of these may aid in identifying subgroups of MDD that are better defined by their aetiology. Specifically, genetic stratification provides an array of tools to do this, including the intermediate phenotype approach which was applied in this thesis. This thesis explores genetic o
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Cuomo, Alessandro. ""TREATMENT-RESISTANT DEPRESSION" AND USE OF INTRAVENOUS KETAMINE AND INTRANASAL ES-KETAMINE." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1148507.

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Treatment-Resistant Depression (TRD) is defined as major depression characterized by the unsatisfactory response of two or more antidepressant therapies (adequate for dosage and duration), associated with a high incidence of comorbidities, with more marked impairment of functioning socio-occupational and greater risks of relapse, recurrence and suicidality. The high incidence of TRD has advanced scientific research towards the study of molecules with antidepressant action and with different mechanisms of action than those based on the monoaminergic theory. Ketamine is one of these molecules. A
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Abel, Anna Lucy. "Examining the process of change in cognitive behaviour therapy for treatment resistant depression." Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/15276.

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Objective: The present studies aimed to examine temporal patterns of symptom change over the course of cognitive behavioural therapy (CBT) in individuals with treatment-resistant depression (TRD) and evaluate their relationship to outcomes. They further sought to investigate whether case-conceptualisation competence, client hope and processing were associated with therapeutic change. Method: Participants were 156 individuals with TRD receiving 12-18 sessions of CBT as part of a randomised controlled trial. Depressive severity was assessed at each session. Audio-recordings of therapy sessions p
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Alkhateeb, Hebah, Gregory A. Ordway, W. Drew Gill, et al. "PARP1 inhibition produces unique antidepressant effects in an animal model of treatment-resistant depression." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/49.

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Major depressive disorder (MDD) is a prevalent and enervating mental illness affecting millions globally. Unfortunately, a significant proportion of patients do not receive clinical benefit from existing antidepressant medications. The limited effectiveness of currently available antidepressant drugs emphasizes the need to identify more effective medications for individuals who are treatment-resistant. We have previously reported abnormally elevated poly (ADP-ribose) polymerase-1 (PARP1) gene expression levels in the postmortem brain from MDD brain donors. PARP1 is a DNA damage repair enzyme t
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Books on the topic "Treatment resistance depression"

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1948-, Extein Irl, ed. Treatment of tricyclic-resistant depression. American Psychiatric Press, 1989.

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D, Amsterdam Jay, Hornig Mady 1957-, and Nierenberg Andrew A. 1955-, eds. Treatment-resistant mood disorders. Cambridge University Press, 2001.

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Kasper, S., and S. A. Montgomery. Treatment-resistant depression. Wiley-Blackwell, 2013.

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Kasper, Siegfried, and Stuart Montgomery. Treatment-resistant Depression. John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118556719.

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Mädy, Hornig-Rohan, and Amsterdam Jay D, eds. Treatment-resistant depression. Saunders, 1996.

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Greden, John F. Treatment resistant depression: A roadmap for effective care. American Psychiatric Pub., 2011.

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Mathew, Sanjay J., and Carlos A. Zarate,, eds. Ketamine for Treatment-Resistant Depression. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42925-0.

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McIntyre, Roger S., and André F. Carvalho. Treatment-resistant mood disorders. Oxford University Press, 2015.

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United States. Congress. Senate. Committee on Finance, ed. Committee staff report to the chairman and ranking member: Review of the FDA's approval process for the vagus nerve stimulation therapy system for treatment-resistant depression. U.S. G.P.O., 2006.

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Selek, Salih, Ives Cavalcante Passos, and Jair C. Soares. The management of treatment-resistant bipolar disorder. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0023.

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Treatment-resistant bipolar disorder is a challenging area in clinical psychiatry and both defining treatment resistance and managing it is difficult despite new emerging pharmacological and non-pharmacological treatments. This chapter revisits the definition in treatment resistance in bipolar and summarizes the general recommendations in treatment-resistant bipolar disorder by taking revision of the guidelines to ‘pole position’. Manic and depressive episodes are covered in different subtitles. A short description of the complementary and alternative treatments is also mentioned. Special cond
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Book chapters on the topic "Treatment resistance depression"

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Kroll, David S. "Treatment Resistance and Advanced Therapies." In Caring for Patients with Depression in Primary Care. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08495-9_6.

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Won, Eunsoo, Byoung-Joo Ham, and Yong-Ku Kim. "Treatment-Resistant Depression: Understandings on the Neurobiological Etiology that Lead to Novel Pharmacological Treatment Options." In Treatment Resistance in Psychiatry. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-4358-1_7.

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Apolinário-Hagen, Jennifer, Lara Fritsche, Liesemarie Albers, and Christel Salewski. "Cognitive Behavioral Therapy and Behavioral Activation Therapy for Treatment-Resistant Depression: Traditional and Digital Therapy Perspectives." In Treatment Resistance in Psychiatry. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-4358-1_21.

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Felger, Jennifer C. "Increased Inflammation and Treatment of Depression: From Resistance to Reuse, Repurposing, and Redesign." In Advances in Neurobiology. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-21054-9_16.

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Souery, Daniel, and William Pitchot. "Definitions and Predictors of Treatment-resistant Depression." In Treatment-resistant Depression. John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118556719.ch1.

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Möller, Hans-Jürgen, Florian Seemüller, Rebecca Schennach, and Ramesh K. Gupta. "Treatment-resistant Depression." In Treatment-resistant Depression. John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118556719.ch2.

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Fabbri, Chiara, Stefano Porcelli, and Alessandro Serretti. "Genetics of Treatment-resistant Depression." In Treatment-resistant Depression. John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118556719.ch3.

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Montgomery, Stuart. "Is There a Role for Switching Antidepressants in Treatment-resistant Depression?" In Treatment-resistant Depression. John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118556719.ch4.

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Kasper, Siegfried, and Elena Akimova. "The Role of Atypical Antipsychotics in Inadequate-response and Treatment-resistant Depression." In Treatment-resistant Depression. John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118556719.ch5.

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Haußmann, Robert, and Michael Bauer. "Lithium, Thyroid Hormones and Further Augmentation Strategies in Treatment-resistant Depression." In Treatment-resistant Depression. John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118556719.ch6.

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Conference papers on the topic "Treatment resistance depression"

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Li, Na, Ziyi Wang, Jun Huang, et al. "Nitrous oxide therapy-induced changes in brain modules of treatment-resistant depression: a randomized controlled study." In 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2024. https://doi.org/10.1109/bibm62325.2024.10822512.

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"From poverty to depression to inflammation: a literature review." In International Conference on Public Health and Humanitarian Action. International Federation of Medical Students' Associations - Jordan, 2022. http://dx.doi.org/10.56950/ovii9740.

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Background: Depression is the most commonly presented psychiatric disorder1 . People with low socioeconomic status are more likely to experience depression compared to those with higher socioeconomic status2 . Recent studies have revealed that people experiencing depression symptoms have a greater vulnerability to infections3 . Also, it has been shown in recent studies that there is a correlation between irregular cytokine levels and an uncontrolled inflammatory response4 . Objective: The present review addresses the relationship between the immune system response and depression. In addition t
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Farias, Suzi Maria Fernandes de, Monica Teixeira Signorini, Daniel Aragão Machado, Carlos Luiz Dias, and Flávio Vaz Machado. "The role of ketamine in the treatment of major depressive disorder: Multidisciplinary approach in psychiatry." In V Seven International Multidisciplinary Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/sevenvmulti2024-140.

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Depression is a prevalent psychiatric condition, affecting millions of people around the world. Major Depressive Disorder (MDD), in turn, is a particularly serious form that can be resistant to conventional treatments. In this context, ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a promising therapy due to its rapid effects in cases of severe and treatment-resistant depression. Symptoms may improve within a few hours after administration and last for up to two weeks. This study seeks to evaluate the efficacy and safety of ketamine as a treatment for MDD, as well
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Warden, Dustin. "TREATING CHRONIC SCHIZOPHRENIA AND COMPLEX TRAUMA THROUGH JUNGIAN DREAMWORK: A PRISON-BASED CASE STUDY." In PsyCon Bangkok–International Conference on Psychology & Psychiatry, 09-10 July 2025. Global Research & Development Services Publishing, 2025. https://doi.org/10.20319/icrlsh.2025.2324.

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This case study documents the integrative treatment of a woman with chronic schizophrenia, complex PTSD, and comorbid anxiety and depression, incarcerated during the COVID-19 pandemic. Her primary symptoms included persistent hallucinations, trauma-driven nightmares, and emotional dysregulation. Traumatic themes of incest, supernatural forces, and violent dream figures dominated her inner world, exacerbated by institutional isolation, grief over a deceased brother, and unresolved family betrayal. Treatment combined Jungian dreamwork, guided hypnagogic induction, symbolic reframing, and trauma-
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ACHTÉ, KALLE, KIMMO KUOPPASALMI, and HANNU NAUKKARINEN. "MODERN VIEWS ON THE TREATMENT OF THERAPY-RESISTANT DEPRESSION." In IX World Congress of Psychiatry. WORLD SCIENTIFIC, 1994. http://dx.doi.org/10.1142/9789814440912_0072.

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Anguita Domingo, D., C. Raventos Aymar, J. Vidal Otero, et al. "4CPS-042 Experience with intranasal esketamine in treatment-resistant depression." In 29th EAHP Congress, Copenhagen, Denmark, 12-13-14 March 2025, Person centred pharmacy — Navigating digital health. British Medical Journal Publishing Group, 2025. https://doi.org/10.1136/ejhpharm-2025-eahp.115.

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Borchert, AntonW, HannahB Maier, Rasmus Schülke, et al. "CYP2C19 and CYP2D6 genotyping in a cohort of patients with treatment-resistant depression." In Abstracts of the 3rd Symposium of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) and Deutsche Gesellschaft für Biologische Psychiatrie (DGBP). Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0042-1757668.

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Osborne, Curtis, Petya Vicheva, and Paul Shotbolt. "#7119 Current neurostimulation targets and techniques for the management of treatment resistant depression." In The BNPA 37th Annual Conference, ‘How do our Situations and Environment Shape Us’, March 2024. BMJ Publishing Group Ltd, 2025. https://doi.org/10.1136/jnnp-2024-bnpa.29.

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Kluglein, Kimberly, David F. Lo, and Don D. Shamilov. "Trichotillomania Case Report." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.167_2024.

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Trichotillomania is a psycho-dermatologic disorder involving self-inflicted hair loss through pulling. Often complicated by anxiety and depression. Multifactorial etiology and limited evidence-based treatment options makes management difficult. Treatment approaches include a combination of pharmacotherapy, CBT, HRT, and ACT. Case presentation involves a 24-year-old female, diagnosed with treatment-resistant trichotillomania who achieved remission and hair regrowth through mindset reframing, physical barriers, and community support. Novel approaches focusing on mindset and community support can
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Bonato, M., S. Gallucci, E. Chiaramello, et al. "Computational Evaluation of Combined Cerebellar and Frontal Transcranial Direct Current Stimulation for Treatment-Resistant Depression." In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2022. http://dx.doi.org/10.1109/embc48229.2022.9871462.

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Reports on the topic "Treatment resistance depression"

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Lenze, Eric, Torie Gettinger, Emily Lenard, et al. Comparing Treatment Approaches for Older Adults with Treatment-Resistant Depression -- The OPTIMUM Study. Patient-Centered Outcomes Research Institute (PCORI), 2023. http://dx.doi.org/10.25302/10.2023.trd.151133321.

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Schmidt, Liane. Ketamine helps change thinking patterns in people with treatment-resistant depression. Edited by Sara Phillips. Monash University, 2022. http://dx.doi.org/10.54377/9a2b-ebe7.

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Alhammad, Fatimah, Mostafa Alhodibi, Anfal Alnujaidi, et al. Efficacy and Safety of Intranasal Ketamine for treatment-Resistant Depression in Pregnant Women. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2025. https://doi.org/10.37766/inplasy2025.6.0007.

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Papakostas, George. Augmentation vs Switching: Comparative Effectiveness Research Trial for Antidepressant Incomplete and Nonresponders with Treatment-Resistant Depression (ASCERTAIN-TRD). Patient-Centered Outcomes Research Institute (PCORI), 2025. https://doi.org/10.25302/03.2025.trd.151133227.

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Qiu, Youjia, Aojie Duan, Ziqian Yin, et al. Efficacy and tolerability of minocycline in depressive patients with or without treatment-resistant: a meta-analysis of randomized controlled trial. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.12.0051.

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Combining mirtazapine with other antidepressants is not effective for treatment-resistant depression. National Institute for Health Research, 2019. http://dx.doi.org/10.3310/signal-000709.

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